{"title":"Cellular Signaling Research","description":"\u003cp\u003eThis collection includes research compounds studied in laboratory models involving cellular signaling pathways, protein interaction networks, gene-expression regulation, receptor-mediated activity, and related biochemical processes.\u003c\/p\u003e\n\u003cp\u003eProducts in this collection may include research peptides, recombinant proteins, small-molecule research reagents, and oral research formulations. Each item is organized for research cataloging purposes only and is intended strictly for laboratory research use.\u003c\/p\u003e\n\u003cp\u003eThese products are not dietary supplements, medications, cosmetics, or consumer health products, and are not for human or veterinary use.\u003c\/p\u003e","products":[{"product_id":"bdnf-recombinant-brain-derived-neurotrophic-factor","title":"BDNF Research Protein – 10mg","description":"\u003ch4 data-path-to-node=\"13\"\u003e\u003cstrong\u003eBDNF (Brain-Derived Neurotrophic Factor) Recombinant\u003c\/strong\u003e\u003c\/h4\u003e\n\u003cp data-path-to-node=\"14\"\u003e\u003cb data-path-to-node=\"14\" data-index-in-node=\"0\"\u003eSequence:\u003c\/b\u003e Homodimer (Non-covalent) | Mature 119 AA Subunits \u003cb data-path-to-node=\"14\" data-index-in-node=\"60\"\u003eFormat:\u003c\/b\u003e Sterile Lyophilized Powder (Vial) \u003cb data-path-to-node=\"14\" data-index-in-node=\"102\"\u003eSource:\u003c\/b\u003e Recombinant (E. coli) \u003cb data-path-to-node=\"14\" data-index-in-node=\"132\"\u003ePurity:\u003c\/b\u003e \u0026gt;98% (SDS-PAGE \u0026amp; HPLC) \u003cb data-path-to-node=\"14\" data-index-in-node=\"163\"\u003eContent:\u003c\/b\u003e 10mg per vial\u003c\/p\u003e\n\u003chr data-path-to-node=\"15\"\u003e\n\u003ch3 data-path-to-node=\"16\"\u003e\u003cb data-path-to-node=\"16\" data-index-in-node=\"0\"\u003eProduct Overview\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp data-path-to-node=\"17\"\u003e\u003cb data-path-to-node=\"17\" data-index-in-node=\"0\"\u003eBrain-Derived Neurotrophic Factor (BDNF)\u003c\/b\u003e is the most widely distributed and thoroughly researched neurotrophin in the mammalian central nervous system. This high-purity recombinant formulation (10mg) is scaled for chronic \u003ci data-path-to-node=\"17\" data-index-in-node=\"222\"\u003ein vivo\u003c\/i\u003e research, metabolic profiling, and systemic administration protocols.\u003c\/p\u003e\n\u003cp data-path-to-node=\"18\"\u003eBDNF acts as a \"pleiotropic modulator,\" orchestrating neuronal survival, differentiation, and synaptic plasticity. It functions via a precise \"Yin and Yang\" mechanism: the mature protein (mBDNF) drives neuroprotection and spinogenesis via the \u003cb data-path-to-node=\"18\" data-index-in-node=\"243\"\u003eTrkB Receptor\u003c\/b\u003e, while its precursor (proBDNF) regulates synaptic pruning via the \u003cb data-path-to-node=\"18\" data-index-in-node=\"323\"\u003ep75NTR\u003c\/b\u003e. This research-grade formulation is optimized to contain high-purity mature protein to ensure robust TrkB activation.\u003c\/p\u003e\n\u003chr data-path-to-node=\"19\"\u003e\n\u003ch3 data-path-to-node=\"20\"\u003e\u003cb data-path-to-node=\"20\" data-index-in-node=\"0\"\u003eMechanism of Action: The TrkB Signaling Axis\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp data-path-to-node=\"21\"\u003eUpon binding to the Tropomyosin receptor kinase B (TrkB), BDNF triggers three canonical signaling cascades essential for neuroplasticity:\u003c\/p\u003e\n\u003cul data-path-to-node=\"22\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"22,0,0\"\u003e\u003cb data-path-to-node=\"22,0,0\" data-index-in-node=\"0\"\u003eRas-MAPK\/ERK Pathway:\u003c\/b\u003e Drives the transcription of immediate-early genes like \u003ci data-path-to-node=\"22,0,0\" data-index-in-node=\"77\"\u003eArc\u003c\/i\u003e and \u003ci data-path-to-node=\"22,0,0\" data-index-in-node=\"85\"\u003ec-Fos\u003c\/i\u003e, which are indispensable for cytoskeletal reorganization.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"22,1,0\"\u003e\u003cb data-path-to-node=\"22,1,0\" data-index-in-node=\"0\"\u003ePI3K-Akt-mTOR Pathway:\u003c\/b\u003e Promotes cell survival by inhibiting apoptotic factors (BAD) and regulating protein translation for dendritic spine growth.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"22,2,0\"\u003e\u003cb data-path-to-node=\"22,2,0\" data-index-in-node=\"0\"\u003ePLC-γ Pathway:\u003c\/b\u003e Mobilizes intracellular Calcium to activate CaMKII, synergizing with MAPK to regulate synaptic strength.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003chr data-path-to-node=\"23\"\u003e\n\u003ch3 data-path-to-node=\"24\"\u003e\u003cb data-path-to-node=\"24\" data-index-in-node=\"0\"\u003eKey Research Applications\u003c\/b\u003e\u003c\/h3\u003e\n\u003ch4 data-path-to-node=\"25\"\u003e\u003cb data-path-to-node=\"25\" data-index-in-node=\"0\"\u003e1. Synaptic Plasticity \u0026amp; Memory (LTP)\u003c\/b\u003e\u003c\/h4\u003e\n\u003cp data-path-to-node=\"26\"\u003eBDNF is the critical mediator of Late-Phase Long-Term Potentiation (L-LTP).\u003c\/p\u003e\n\u003cul data-path-to-node=\"27\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"27,0,0\"\u003e\u003cb data-path-to-node=\"27,0,0\" data-index-in-node=\"0\"\u003eElectrophysiology:\u003c\/b\u003e Research in hippocampal slices demonstrates that BDNF infusion enhances the field excitatory postsynaptic potential (fEPSP) slope by over \u003cb data-path-to-node=\"27,0,0\" data-index-in-node=\"157\"\u003e60%\u003c\/b\u003e, significantly facilitating memory consolidation.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"27,1,0\"\u003e\u003cb data-path-to-node=\"27,1,0\" data-index-in-node=\"0\"\u003eDendritic Morphology:\u003c\/b\u003e Treatment shifts dendritic spines toward a mature \"mushroom\" phenotype, increasing spine density in the CA1 region.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch4 data-path-to-node=\"28\"\u003e\u003cb data-path-to-node=\"28\" data-index-in-node=\"0\"\u003e2. Neurodegenerative Rescue (Alzheimer's \u0026amp; Depression)\u003c\/b\u003e\u003c\/h4\u003e\n\u003cul data-path-to-node=\"29\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"29,0,0\"\u003e\u003cb data-path-to-node=\"29,0,0\" data-index-in-node=\"0\"\u003eAlzheimer's Models:\u003c\/b\u003e In transgenic amyloid models (J20), viral delivery of BDNF to the entorhinal cortex prevented spatial memory deficits, suggesting it confers \"synaptic resilience\" against amyloid toxicity.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"29,1,0\"\u003e\u003cb data-path-to-node=\"29,1,0\" data-index-in-node=\"0\"\u003eDepression:\u003c\/b\u003e In the Forced Swim Test (FST), intrahippocampal BDNF has been shown to restore mobility in corticosterone-exposed models, mimicking the efficacy of chronic antidepressant treatment.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch4 data-path-to-node=\"30\"\u003e\u003cb data-path-to-node=\"30\" data-index-in-node=\"0\"\u003e3. Systemic Physiology (Cardiac \u0026amp; Metabolic)\u003c\/b\u003e\u003c\/h4\u003e\n\u003cp data-path-to-node=\"31\"\u003eBDNF is a potent myokine and cardiokine.\u003c\/p\u003e\n\u003cul data-path-to-node=\"32\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"32,0,0\"\u003e\u003cb data-path-to-node=\"32,0,0\" data-index-in-node=\"0\"\u003eCardiac Repair:\u003c\/b\u003e In ischemia-reperfusion models, BDNF administration reduced total infarct volume by approximately \u003cb data-path-to-node=\"32,0,0\" data-index-in-node=\"114\"\u003e47%\u003c\/b\u003e by counter-regulating apoptotic ratios.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"32,1,0\"\u003e\u003cb data-path-to-node=\"32,1,0\" data-index-in-node=\"0\"\u003eMetabolic Regulation:\u003c\/b\u003e In diabetic (db\/db) mice, systemic BDNF enhanced glucose utilization in skeletal muscle via AMPK pathways, independent of insulin.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003chr data-path-to-node=\"33\"\u003e\n\u003ch3 data-path-to-node=\"34\"\u003e\u003cb data-path-to-node=\"34\" data-index-in-node=\"0\"\u003eChemical Specifications\u003c\/b\u003e\u003c\/h3\u003e\n\u003cul data-path-to-node=\"35\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"35,0,0\"\u003e\u003cb data-path-to-node=\"35,0,0\" data-index-in-node=\"0\"\u003eMolecular Weight:\u003c\/b\u003e ~27.0 kDa (Homodimer)\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"35,1,0\"\u003e\u003cb data-path-to-node=\"35,1,0\" data-index-in-node=\"0\"\u003eStructure:\u003c\/b\u003e Cystine-knot motif with three intrachain disulfide bonds per monomer.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"35,2,0\"\u003e\u003cb data-path-to-node=\"35,2,0\" data-index-in-node=\"0\"\u003eHomology:\u003c\/b\u003e Mature human BDNF shares absolute sequence identity with murine BDNF, making this recombinant human protein fully bioactive in mouse and rat models.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003chr data-path-to-node=\"37\"\u003e\n\u003ch3 data-path-to-node=\"38\"\u003e\u003cb data-path-to-node=\"38\" data-index-in-node=\"0\"\u003eStorage \u0026amp; Handling\u003c\/b\u003e\u003c\/h3\u003e\n\u003cul data-path-to-node=\"39\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"39,0,0\"\u003e\u003cb data-path-to-node=\"39,0,0\" data-index-in-node=\"0\"\u003ePhysical State:\u003c\/b\u003e Lyophilized (Freeze-Dried) Powder.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"39,1,0\"\u003e\u003cb data-path-to-node=\"39,1,0\" data-index-in-node=\"0\"\u003eStorage (Powder):\u003c\/b\u003e Store at -20°C to -80°C. Stable for up to 2 years.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"39,2,0\"\u003e\u003cb data-path-to-node=\"39,2,0\" data-index-in-node=\"0\"\u003eReconstitution:\u003c\/b\u003e\u003c\/p\u003e\n\u003cul data-path-to-node=\"39,2,1\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"39,2,1,0,0\"\u003e\u003cb data-path-to-node=\"39,2,1,0,0\" data-index-in-node=\"0\"\u003eConcentration:\u003c\/b\u003e Reconstitute to \u003cb data-path-to-node=\"39,2,1,0,0\" data-index-in-node=\"31\"\u003eno less than 100 µg\/mL\u003c\/b\u003e (0.1 mg\/mL) to prevent adsorption to vial walls.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"39,2,1,1,0\"\u003e\u003cb data-path-to-node=\"39,2,1,1,0\" data-index-in-node=\"0\"\u003eSolvent:\u003c\/b\u003e Sterile Water or 0.4% NaHCO3.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"39,3,0\"\u003e\u003cb data-path-to-node=\"39,3,0\" data-index-in-node=\"0\"\u003eStorage (Liquid):\u003c\/b\u003e Store at 4°C for up to 1 week. For long-term, aliquot and freeze at -20°C. \u003cb data-path-to-node=\"39,3,0\" data-index-in-node=\"93\"\u003eAvoid freeze-thaw cycles.\u003c\/b\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003chr data-path-to-node=\"40\"\u003e\n\u003ch3 data-path-to-node=\"41\"\u003e\u003cb data-path-to-node=\"41\" data-index-in-node=\"0\"\u003eDisclaimer\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp data-path-to-node=\"42\"\u003e\u003cb data-path-to-node=\"42\" data-index-in-node=\"0\"\u003eFOR RESEARCH USE ONLY.\u003c\/b\u003e This product is a chemical compound intended strictly for laboratory research and development. It is not approved by the FDA for clinical use, diagnostics, or therapeutic procedures in humans or animals. The physiological and toxicological properties of this chemical have not been fully investigated.\u003c\/p\u003e","brand":"Peptagon","offers":[{"title":"Default Title","offer_id":47709778706646,"sku":"BDNF-10","price":124.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0783\/3085\/5638\/files\/BDNF-10mgm.png?v=1768510121"},{"product_id":"cardiogen-ala-glu-asp-arg-research-peptide","title":"Cardiogen Research Peptide – 25mg","description":"\u003ch4 data-path-to-node=\"13\"\u003e\u003cstrong\u003eCardiogen Peptide (Lyophilized)\u003c\/strong\u003e\u003c\/h4\u003e\n\u003cp data-path-to-node=\"14\"\u003e\u003cb data-path-to-node=\"14\" data-index-in-node=\"0\"\u003eSequence:\u003c\/b\u003e Ala-Glu-Asp-Arg (AEDR) \u003cb data-path-to-node=\"14\" data-index-in-node=\"33\"\u003eFormat:\u003c\/b\u003e Sterile Lyophilized Powder (Vial) \u003cb data-path-to-node=\"14\" data-index-in-node=\"75\"\u003eClass:\u003c\/b\u003e Synthetic Peptide Bioregulator (Cytogen) \u003cb data-path-to-node=\"14\" data-index-in-node=\"123\"\u003ePurity:\u003c\/b\u003e \u0026gt;98% (HPLC) \u003cb data-path-to-node=\"14\" data-index-in-node=\"143\"\u003eContent:\u003c\/b\u003e 20mg per vial\u003c\/p\u003e\n\u003chr data-path-to-node=\"15\"\u003e\n\u003ch3 data-path-to-node=\"16\"\u003e\u003cb data-path-to-node=\"16\" data-index-in-node=\"0\"\u003eProduct Overview\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp data-path-to-node=\"17\"\u003e\u003cb data-path-to-node=\"17\" data-index-in-node=\"0\"\u003eCardiogen\u003c\/b\u003e is a synthetic tetrapeptide (Ala-Glu-Asp-Arg) developed based on the amino acid analysis of cardiac tissue extracts. It belongs to the class of \"Cytogens\"—short-chain bioregulators designed to mimic endogenous signaling molecules that govern tissue repair and homeostasis.\u003c\/p\u003e\n\u003cp data-path-to-node=\"18\"\u003eUnlike standard cardiovascular pharmaceuticals that block receptors (e.g., Beta-blockers) or inhibit enzymes (e.g., ACE inhibitors), Cardiogen is posited to function as an \u003cb data-path-to-node=\"18\" data-index-in-node=\"172\"\u003eepigenetic modulator\u003c\/b\u003e. Research suggests it intervenes at the genomic level, initiating transcriptional programs that revitalize the protein synthetic machinery of cardiomyocytes and normalize extracellular matrix turnover. It is extensively studied for its potential in myocardial infarction recovery and the prevention of age-related cardiac decline.\u003c\/p\u003e\n\u003chr data-path-to-node=\"19\"\u003e\n\u003ch3 data-path-to-node=\"20\"\u003e\u003cb data-path-to-node=\"20\" data-index-in-node=\"0\"\u003eMechanism of Action: Epigenetic Regulation\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp data-path-to-node=\"21\"\u003eCardiogen functions according to the \"Peptide-DNA Interaction Theory.\" Its specific charge profile (Acidic Core\/Basic Terminus) allows it to enter the nucleus and bind directly to the major groove of DNA in GC-rich promoter regions.\u003c\/p\u003e\n\u003cul data-path-to-node=\"22\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"22,0,0\"\u003e\u003cb data-path-to-node=\"22,0,0\" data-index-in-node=\"0\"\u003eChromatin Decondensation:\u003c\/b\u003e Binding induces the \"unwinding\" (deheterochromatinization) of silenced chromatin, making genes accessible to transcription factors.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"22,1,0\"\u003e\u003cb data-path-to-node=\"22,1,0\" data-index-in-node=\"0\"\u003eTranscriptional Targets:\u003c\/b\u003e\u003c\/p\u003e\n\u003cul data-path-to-node=\"22,1,1\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"22,1,1,0,0\"\u003e\u003cb data-path-to-node=\"22,1,1,0,0\" data-index-in-node=\"0\"\u003eUpregulation:\u003c\/b\u003e Stimulates expression of proliferation markers (\u003cb data-path-to-node=\"22,1,1,0,0\" data-index-in-node=\"62\"\u003eKi-67\u003c\/b\u003e, \u003cb data-path-to-node=\"22,1,1,0,0\" data-index-in-node=\"69\"\u003ePCNA\u003c\/b\u003e) and differentiation factors (\u003cb data-path-to-node=\"22,1,1,0,0\" data-index-in-node=\"104\"\u003eNkx2.5\u003c\/b\u003e, \u003cb data-path-to-node=\"22,1,1,0,0\" data-index-in-node=\"112\"\u003eGATA4\u003c\/b\u003e) in cardiac tissue.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"22,1,1,1,0\"\u003e\u003cb data-path-to-node=\"22,1,1,1,0\" data-index-in-node=\"0\"\u003eDownregulation:\u003c\/b\u003e Uniquely downregulates \u003cb data-path-to-node=\"22,1,1,1,0\" data-index-in-node=\"39\"\u003ep53\u003c\/b\u003e (apoptosis checkpoint) in ischemic heart tissue, promoting cell survival during stress.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003chr data-path-to-node=\"23\"\u003e\n\u003ch3 data-path-to-node=\"24\"\u003e\u003cb data-path-to-node=\"24\" data-index-in-node=\"0\"\u003eKey Research Applications\u003c\/b\u003e\u003c\/h3\u003e\n\u003ch4 data-path-to-node=\"25\"\u003e\u003cb data-path-to-node=\"25\" data-index-in-node=\"0\"\u003e1. Myocardial Infarction \u0026amp; Ischemia\u003c\/b\u003e\u003c\/h4\u003e\n\u003cp data-path-to-node=\"26\"\u003eCardiogen is investigated for its ability to reduce infarct size and mortality in rodent models of coronary artery ligation.\u003c\/p\u003e\n\u003cul data-path-to-node=\"27\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"27,0,0\"\u003e\u003cb data-path-to-node=\"27,0,0\" data-index-in-node=\"0\"\u003eMetabolic Shielding:\u003c\/b\u003e It aids in the preservation of myocardial glycogen stores and mitochondrial integrity during hypoxia.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"27,1,0\"\u003e\u003cb data-path-to-node=\"27,1,0\" data-index-in-node=\"0\"\u003eTissue Salvage:\u003c\/b\u003e By suppressing p53-mediated apoptosis specifically in the heart, it preserves the \"penumbra\" (at-risk tissue) surrounding the necrotic core.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch4 data-path-to-node=\"28\"\u003e\u003cb data-path-to-node=\"28\" data-index-in-node=\"0\"\u003e2. Fibrosis \u0026amp; Remodeling\u003c\/b\u003e\u003c\/h4\u003e\n\u003cp data-path-to-node=\"29\"\u003eHeart failure is often driven by excessive scarring (fibrosis). Cardiogen acts to restore the equilibrium between cardiomyocytes and fibroblasts.\u003c\/p\u003e\n\u003cul data-path-to-node=\"30\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"30,0,0\"\u003e\u003cb data-path-to-node=\"30,0,0\" data-index-in-node=\"0\"\u003eFibroblast Modulation:\u003c\/b\u003e It discourages the \"myofibroblast\" phenotype, reducing excessive collagen deposition.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"30,1,0\"\u003e\u003cb data-path-to-node=\"30,1,0\" data-index-in-node=\"0\"\u003eMatrix Integrity:\u003c\/b\u003e Promotes the synthesis of physiological structural proteins (Actin, Vimentin, Lamin A\/C) rather than scar tissue, helping to maintain ventricular geometry and prevent dilation.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch4 data-path-to-node=\"31\"\u003e\u003cb data-path-to-node=\"31\" data-index-in-node=\"0\"\u003e3. Oncological Safety (The p53 Paradox)\u003c\/b\u003e\u003c\/h4\u003e\n\u003cp data-path-to-node=\"32\"\u003eA critical distinction in Cardiogen research is its context-dependent action. While it suppresses p53 in healthy heart tissue to prevent cell death, studies (Levdik \u0026amp; Knyazkin) indicate it \u003cb data-path-to-node=\"32\" data-index-in-node=\"189\"\u003einhibits\u003c\/b\u003e tumor growth (e.g., M-1 Sarcoma) by inducing hemorrhagic necrosis in tumor vasculature. This suggests a true \"bioregulatory\" function—supporting homeostasis while disrupting pathology.\u003c\/p\u003e\n\u003chr data-path-to-node=\"33\"\u003e\n\u003ch3 data-path-to-node=\"34\"\u003e\u003cb data-path-to-node=\"34\" data-index-in-node=\"0\"\u003eImportant Distinction: Cardiogen vs. Cardiogenol C\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp data-path-to-node=\"35\"\u003eResearchers must distinguish between two similarly named but chemically distinct compounds:\u003c\/p\u003e\n\u003cul data-path-to-node=\"36\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"36,0,0\"\u003e\u003cb data-path-to-node=\"36,0,0\" data-index-in-node=\"0\"\u003eCardiogen (This Product):\u003c\/b\u003e A synthetic \u003cb data-path-to-node=\"36,0,0\" data-index-in-node=\"38\"\u003etetrapeptide (Ala-Glu-Asp-Arg)\u003c\/b\u003e used for in vivo bioregulation and tissue repair.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"36,1,0\"\u003e\u003cb data-path-to-node=\"36,1,0\" data-index-in-node=\"0\"\u003eCardiogenol C:\u003c\/b\u003e A synthetic \u003cb data-path-to-node=\"36,1,0\" data-index-in-node=\"27\"\u003esmall molecule (Diaminopyrimidine)\u003c\/b\u003e used primarily in vitro to force stem cell differentiation.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"36,2,0\"\u003e\u003ci data-path-to-node=\"36,2,0\" data-index-in-node=\"0\"\u003eThis listing is for the Tetrapeptide (AEDR).\u003c\/i\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003chr data-path-to-node=\"37\"\u003e\n\u003ch3 data-path-to-node=\"38\"\u003e\u003cb data-path-to-node=\"38\" data-index-in-node=\"0\"\u003eStorage \u0026amp; Handling\u003c\/b\u003e\u003c\/h3\u003e\n\u003cul data-path-to-node=\"39\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"39,0,0\"\u003e\u003cb data-path-to-node=\"39,0,0\" data-index-in-node=\"0\"\u003ePhysical State:\u003c\/b\u003e Lyophilized (Freeze-Dried) Powder.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"39,1,0\"\u003e\u003cb data-path-to-node=\"39,1,0\" data-index-in-node=\"0\"\u003eStorage (Powder):\u003c\/b\u003e Store at -20°C (Freezer). Stable for up to 24 months.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"39,2,0\"\u003e\u003cb data-path-to-node=\"39,2,0\" data-index-in-node=\"0\"\u003eReconstitution:\u003c\/b\u003e\u003c\/p\u003e\n\u003cul data-path-to-node=\"39,2,1\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"39,2,1,0,0\"\u003e\u003cb data-path-to-node=\"39,2,1,0,0\" data-index-in-node=\"0\"\u003eSolvent:\u003c\/b\u003e Bacteriostatic Water or Sterile Saline.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"39,2,1,1,0\"\u003e\u003cb data-path-to-node=\"39,2,1,1,0\" data-index-in-node=\"0\"\u003eSolubility:\u003c\/b\u003e Hydrophilic and readily soluble.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"39,3,0\"\u003e\u003cb data-path-to-node=\"39,3,0\" data-index-in-node=\"0\"\u003eStorage (Liquid):\u003c\/b\u003e Store at 4°C (Refrigerator). Use within 14 days to prevent degradation.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003chr data-path-to-node=\"40\"\u003e\n\u003ch3 data-path-to-node=\"41\"\u003e\u003cb data-path-to-node=\"41\" data-index-in-node=\"0\"\u003eDisclaimer\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp data-path-to-node=\"42\"\u003e\u003cb data-path-to-node=\"42\" data-index-in-node=\"0\"\u003eFOR RESEARCH USE ONLY.\u003c\/b\u003e This product is a chemical compound intended strictly for laboratory research and development. It is not approved by the FDA for clinical use, diagnostics, or therapeutic procedures in humans or animals. The physiological and toxicological properties of this chemical have not been fully investigated.\u003c\/p\u003e","brand":"Peptagon","offers":[{"title":"Default Title","offer_id":47709951918294,"sku":"CARDIO-25","price":36.0,"currency_code":"USD","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0783\/3085\/5638\/files\/Cardiogen-20MG.png?v=1768510161"},{"product_id":"curcumin-natural-polyphenol-research-reagent","title":"Curcumin Research Reagent – 600mg","description":"\u003ch4 data-path-to-node=\"13\"\u003e\u003cstrong\u003eCurcumin Research Reagent (Crystalline)\u003c\/strong\u003e\u003c\/h4\u003e\n\u003cp data-path-to-node=\"14\"\u003e\u003cb data-index-in-node=\"0\" data-path-to-node=\"14\"\u003eIUPAC Name:\u003c\/b\u003e (1E,6E)-1,7-bis(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione \u003cb data-index-in-node=\"80\" data-path-to-node=\"14\"\u003eFormat:\u003c\/b\u003e Crystalline Yellow-Orange Powder \u003cb data-index-in-node=\"121\" data-path-to-node=\"14\"\u003eClass:\u003c\/b\u003e Polyphenol (Diarylheptanoid) \u003cb data-index-in-node=\"157\" data-path-to-node=\"14\"\u003ePurity:\u003c\/b\u003e \u0026gt;98% (HPLC) \u003cb data-index-in-node=\"177\" data-path-to-node=\"14\"\u003eContent:\u003c\/b\u003e 600mg per jar \u003cb data-index-in-node=\"200\" data-path-to-node=\"14\"\u003eSolubility:\u003c\/b\u003e DMSO, Ethanol (Practically insoluble in water)\u003cbr\u003e\u003c\/p\u003e\n\u003chr data-path-to-node=\"16\"\u003e\n\u003ch3 data-path-to-node=\"17\"\u003e\u003cb data-index-in-node=\"0\" data-path-to-node=\"17\"\u003eProduct Overview\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp data-path-to-node=\"18\"\u003e\u003cb data-index-in-node=\"0\" data-path-to-node=\"18\"\u003eCurcumin\u003c\/b\u003e is the principal bioactive curcuminoid isolated from \u003ci data-index-in-node=\"62\" data-path-to-node=\"18\"\u003eCurcuma longa\u003c\/i\u003e. Unlike the peptides found in our catalog, Curcumin is a \u003cb data-index-in-node=\"133\" data-path-to-node=\"18\"\u003ehydrophobic polyphenol\u003c\/b\u003e characterized by its pleiotropic ability to modulate multiple cell signaling pathways simultaneously.\u003c\/p\u003e\n\u003cp data-path-to-node=\"19\"\u003eThis \u003cb data-index-in-node=\"5\" data-path-to-node=\"19\"\u003e600mg Research-Grade\u003c\/b\u003e formulation is scaled to accommodate the molecule's specific pharmacokinetic profile. Due to extensive first-pass metabolism and low systemic bioavailability, high-concentration research protocols are often required to achieve pharmacologically relevant serum levels for \u003ci data-index-in-node=\"297\" data-path-to-node=\"19\"\u003ein vitro\u003c\/i\u003e and \u003ci data-index-in-node=\"310\" data-path-to-node=\"19\"\u003ein vivo\u003c\/i\u003e investigation. It is a potent probe for dissecting inflammatory cascades, amyloid pathology, and oncological signaling.\u003c\/p\u003e\n\u003chr data-path-to-node=\"20\"\u003e\n\u003ch3 data-path-to-node=\"21\"\u003e\u003cb data-index-in-node=\"0\" data-path-to-node=\"21\"\u003eMechanism of Action: The Master Switch\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp data-path-to-node=\"22\"\u003eCurcumin acts as a broad-spectrum modulator of the inflammatory genome, intercepting pathogenic signals at the transcriptional level.\u003c\/p\u003e\n\u003cul data-path-to-node=\"23\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"23,0,0\"\u003e\u003cb data-index-in-node=\"0\" data-path-to-node=\"23,0,0\"\u003eNF-κB Suppression:\u003c\/b\u003e It directly inhibits IKKβ, preventing the phosphorylation of IκBα. This sequesters the transcription factor NF-κB in the cytoplasm, halting the production of inflammatory cytokines (TNF-α, IL-6).\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"23,1,0\"\u003e\u003cb data-index-in-node=\"0\" data-path-to-node=\"23,1,0\"\u003eDual Eicosanoid Inhibition:\u003c\/b\u003e Uniquely acts as a dual inhibitor of both \u003cb data-index-in-node=\"70\" data-path-to-node=\"23,1,0\"\u003eCOX-2\u003c\/b\u003e (prostaglandins) and \u003cb data-index-in-node=\"97\" data-path-to-node=\"23,1,0\"\u003e5-LOX\u003c\/b\u003e (leukotrienes), shutting down arachidonic acid metabolism without the gastric toxicity associated with COX-1 inhibition.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"23,2,0\"\u003e\u003cb data-index-in-node=\"0\" data-path-to-node=\"23,2,0\"\u003eAntioxidant (Nrf2):\u003c\/b\u003e Activates the Nrf2 pathway, driving the expression of cytoprotective enzymes like Heme Oxygenase-1 (HO-1) and Superoxide Dismutase (SOD).\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003chr data-path-to-node=\"24\"\u003e\n\u003ch3 data-path-to-node=\"25\"\u003e\u003cb data-index-in-node=\"0\" data-path-to-node=\"25\"\u003eKey Research Applications\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp data-path-to-node=\"26\"\u003e\u003cb data-index-in-node=\"0\" data-path-to-node=\"26\"\u003e1. Autoimmunity \u0026amp; Inflammation (Arthritis)\u003c\/b\u003e In Collagen-Induced Arthritis (CIA) models, Curcumin demonstrates significant anti-inflammatory activity.\u003c\/p\u003e\n\u003cul data-path-to-node=\"27\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"27,0,0\"\u003e\u003cb data-index-in-node=\"0\" data-path-to-node=\"27,0,0\"\u003eEdema Reduction:\u003c\/b\u003e High-dose protocols suppressed paw edema by ~58%, comparable to standard NSAIDs but with a delayed onset of action consistent with genomic regulation.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"27,1,0\"\u003e\u003cb data-index-in-node=\"0\" data-path-to-node=\"27,1,0\"\u003eJoint Preservation:\u003c\/b\u003e Downregulates MMP-1 and MMP-3, preventing the enzymatic degradation of cartilage architecture.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp data-path-to-node=\"28\"\u003e\u003cb data-index-in-node=\"0\" data-path-to-node=\"28\"\u003e2. Neurodegeneration (Alzheimer's \u0026amp; BDNF)\u003c\/b\u003e Curcumin is lipophilic and crosses the Blood-Brain Barrier (BBB).\u003c\/p\u003e\n\u003cul data-path-to-node=\"29\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"29,0,0\"\u003e\u003cb data-index-in-node=\"0\" data-path-to-node=\"29,0,0\"\u003eAmyloid Clearance:\u003c\/b\u003e Enhances macrophage phagocytosis of Amyloid-β plaques and inhibits fibril aggregation.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"29,1,0\"\u003e\u003cb data-index-in-node=\"0\" data-path-to-node=\"29,1,0\"\u003eBDNF Restoration:\u003c\/b\u003e In models of depression and cognitive decline, it restores brain levels of \u003cb data-index-in-node=\"93\" data-path-to-node=\"29,1,0\"\u003eBrain-Derived Neurotrophic Factor (BDNF)\u003c\/b\u003e to near-wild-type levels, promoting neuroplasticity.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp data-path-to-node=\"30\"\u003e\u003cb data-index-in-node=\"0\" data-path-to-node=\"30\"\u003e3. Oncology (Chemosensitization)\u003c\/b\u003e Investigated for its ability to reverse Multi-Drug Resistance (MDR). In colorectal and breast cancer xenografts, Curcumin potentiates the effects of chemotherapeutics (like 5-FU), significantly reducing tumor volume via apoptosis induction (Bcl-2 downregulation).\u003c\/p\u003e\n\u003chr data-path-to-node=\"31\"\u003e\n\u003ch3 data-path-to-node=\"32\"\u003e\u003cb data-index-in-node=\"0\" data-path-to-node=\"32\"\u003eHandling \u0026amp; Bioavailability\u003c\/b\u003e\u003c\/h3\u003e\n\u003cul data-path-to-node=\"33\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"33,0,0\"\u003e\u003cb data-index-in-node=\"0\" data-path-to-node=\"33,0,0\"\u003eClassification:\u003c\/b\u003e \u003cb data-index-in-node=\"16\" data-path-to-node=\"33,0,0\"\u003eNOT A PEPTIDE.\u003c\/b\u003e This is a lipophilic polyphenol.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"33,1,0\"\u003e\u003cb data-index-in-node=\"0\" data-path-to-node=\"33,1,0\"\u003eSolubility:\u003c\/b\u003e Insoluble in water. Must be solubilized in organic solvents like \u003cb data-index-in-node=\"77\" data-path-to-node=\"33,1,0\"\u003eDMSO\u003c\/b\u003e (\u0026gt;11 mg\/mL) or \u003cb data-index-in-node=\"97\" data-path-to-node=\"33,1,0\"\u003eEthanol\u003c\/b\u003e for stock solutions.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"33,2,0\"\u003e\u003cb data-index-in-node=\"0\" data-path-to-node=\"33,2,0\"\u003eBioavailability:\u003c\/b\u003e Poor systemic absorption. Research often utilizes advanced carriers (PLGA nanoparticles, liposomes, or phytosomes) or high-dose protocols (like this 600mg quantity) to overcome rapid glucuronidation.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"33,3,0\"\u003e\u003cb data-index-in-node=\"0\" data-path-to-node=\"33,3,0\"\u003eStability:\u003c\/b\u003e Light sensitive. Store in amber vials at -20°C to prevent oxidative degradation. Unstable in alkaline buffers (pH \u0026gt; 7).\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003chr data-path-to-node=\"34\"\u003e\n\u003ch3 data-path-to-node=\"35\"\u003e\u003cb data-index-in-node=\"0\" data-path-to-node=\"35\"\u003eDisclaimer\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp data-path-to-node=\"36\"\u003e\u003cb data-index-in-node=\"0\" data-path-to-node=\"36\"\u003eFOR RESEARCH USE ONLY.\u003c\/b\u003e This product is a chemical compound intended strictly for laboratory research and development. It is not approved by the FDA for clinical use, diagnostics, or therapeutic procedures in humans or animals. The physiological and toxicological properties of this chemical have not been fully investigated.\u003c\/p\u003e","brand":"Peptagon","offers":[{"title":"Default Title","offer_id":47710005067990,"sku":"CURCUMIN-600","price":132.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0783\/3085\/5638\/files\/Curcumin-600mg_ae839c76-d94c-4ed2-813d-2a770b8b2ba9.png?v=1768510191"},{"product_id":"epithalon-aedg-tetrapeptide-research-peptide","title":"Epithalon Research Peptide – 10mg \/ 50mg","description":"\u003ch4 data-path-to-node=\"13\"\u003e\u003cstrong\u003eEpithalon Peptide (Lyophilized)\u003c\/strong\u003e\u003c\/h4\u003e\n\u003cp data-path-to-node=\"14\"\u003e\u003cb data-path-to-node=\"14\" data-index-in-node=\"0\"\u003eSequence:\u003c\/b\u003e Ala-Glu-Asp-Gly (AEDG) \u003cb data-path-to-node=\"14\" data-index-in-node=\"33\"\u003eFormat:\u003c\/b\u003e Sterile Lyophilized Powder (Vial) \u003cb data-path-to-node=\"14\" data-index-in-node=\"75\"\u003eClass:\u003c\/b\u003e Synthetic Peptide Bioregulator (Pineal Mimetic) \u003cb data-path-to-node=\"14\" data-index-in-node=\"130\"\u003ePurity:\u003c\/b\u003e \u0026gt;98% (HPLC) \u003cb data-path-to-node=\"14\" data-index-in-node=\"150\"\u003eContent:\u003c\/b\u003e Available in 10mg and 50mg vials\u003c\/p\u003e\n\u003chr data-path-to-node=\"15\"\u003e\n\u003ch3 data-path-to-node=\"16\"\u003e\u003cb data-path-to-node=\"16\" data-index-in-node=\"0\"\u003eProduct Overview\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp data-path-to-node=\"17\"\u003e\u003cb data-path-to-node=\"17\" data-index-in-node=\"0\"\u003eEpithalon\u003c\/b\u003e (also known as Epitalon or AEDG) is a synthetic tetrapeptide designed to mimic the biological activity of Epithalamin, a pineal gland extract. It is a foundational compound in the field of \"bioregulator\" peptides.\u003c\/p\u003e\n\u003cp data-path-to-node=\"18\"\u003eUnlike its naturally derived precursor, Epithalon is a single, precise molecular entity (Ala-Glu-Asp-Gly). Its primary research significance lies in its capacity to activate the enzyme \u003cb data-path-to-node=\"18\" data-index-in-node=\"185\"\u003etelomerase\u003c\/b\u003e (specifically the catalytic subunit hTERT) and modulate chromatin structure. It is extensively studied for its potential to extend replicative lifespan, regulate circadian rhythms, and influence geroprotective gene expression.\u003c\/p\u003e\n\u003chr data-path-to-node=\"19\"\u003e\n\u003ch3 data-path-to-node=\"20\"\u003e\u003cb data-path-to-node=\"20\" data-index-in-node=\"0\"\u003eMechanism of Action: Epigenetic Telomerase Activation\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp data-path-to-node=\"21\"\u003eEpithalon functions as an epigenetic modulator, interacting directly with the genome rather than cell surface receptors.\u003c\/p\u003e\n\u003cul data-path-to-node=\"22\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"22,0,0\"\u003e\u003cb data-path-to-node=\"22,0,0\" data-index-in-node=\"0\"\u003eChromatin Decondensation:\u003c\/b\u003e It binds to specific histone proteins (H1\/3, H1\/6), relaxing condensed chromatin (heterochromatin). This \"unlocks\" silenced genes associated with protein synthesis and cellular repair.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"22,1,0\"\u003e\u003cb data-path-to-node=\"22,1,0\" data-index-in-node=\"0\"\u003eTelomerase Upregulation:\u003c\/b\u003e By reactivating the \u003ci data-path-to-node=\"22,1,0\" data-index-in-node=\"45\"\u003ehTERT\u003c\/i\u003e gene, Epithalon induces telomere elongation. In human fibroblast cultures, this has been shown to extend the \"Hayflick limit\" (the number of times a cell can divide) by over 10 passages.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"22,2,0\"\u003e\u003cb data-path-to-node=\"22,2,0\" data-index-in-node=\"0\"\u003eGene Regulation:\u003c\/b\u003e Downregulates senescence markers like \u003cb data-path-to-node=\"22,2,0\" data-index-in-node=\"55\"\u003ep16 (INK4a)\u003c\/b\u003e and \u003cb data-path-to-node=\"22,2,0\" data-index-in-node=\"71\"\u003ep21 (Waf1)\u003c\/b\u003e, delaying cellular aging.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003chr data-path-to-node=\"23\"\u003e\n\u003ch3 data-path-to-node=\"24\"\u003e\u003cb data-path-to-node=\"24\" data-index-in-node=\"0\"\u003eKey Research Applications\u003c\/b\u003e\u003c\/h3\u003e\n\u003ch4 data-path-to-node=\"25\"\u003e\u003cb data-path-to-node=\"25\" data-index-in-node=\"0\"\u003e1. Longevity \u0026amp; Geroprotection\u003c\/b\u003e\u003c\/h4\u003e\n\u003cp data-path-to-node=\"26\"\u003eLongitudinal studies (Khavinson et al.) in rodents have demonstrated that Epithalon can increase maximum lifespan by \u003cb data-path-to-node=\"26\" data-index-in-node=\"117\"\u003e11-25%\u003c\/b\u003e.\u003c\/p\u003e\n\u003cul data-path-to-node=\"27\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"27,0,0\"\u003e\u003cb data-path-to-node=\"27,0,0\" data-index-in-node=\"0\"\u003eMortality Reduction:\u003c\/b\u003e In long-term human observations (15 years), pineal peptide preparations were associated with a significant reduction in all-cause mortality.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"27,1,0\"\u003e\u003cb data-path-to-node=\"27,1,0\" data-index-in-node=\"0\"\u003eCircadian Rhythm:\u003c\/b\u003e Restores the youthful secretion of melatonin and normalizes cortisol levels in aged primate models.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch4 data-path-to-node=\"28\"\u003e\u003cb data-path-to-node=\"28\" data-index-in-node=\"0\"\u003e2. Oncology (Tumor Inhibition)\u003c\/b\u003e\u003c\/h4\u003e\n\u003cp data-path-to-node=\"29\"\u003eContradicting the fear that telomerase activation promotes cancer, Epithalon has shown \u003cb data-path-to-node=\"29\" data-index-in-node=\"87\"\u003eoncostatic\u003c\/b\u003e effects.\u003c\/p\u003e\n\u003cul data-path-to-node=\"30\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"30,0,0\"\u003e\u003cb data-path-to-node=\"30,0,0\" data-index-in-node=\"0\"\u003eTumor Suppression:\u003c\/b\u003e In rats with M-1 sarcoma, it inhibited tumor growth and induced \"hemorrhagic necrosis\" of the tumor mass.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"30,1,0\"\u003e\u003cb data-path-to-node=\"30,1,0\" data-index-in-node=\"0\"\u003eHER-2\/neu Suppression:\u003c\/b\u003e In transgenic mice, it downregulated the breast cancer oncogene \u003ci data-path-to-node=\"30,1,0\" data-index-in-node=\"87\"\u003eHER-2\/neu\u003c\/i\u003e, reducing tumor incidence and size.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch4 data-path-to-node=\"31\"\u003e\u003cb data-path-to-node=\"31\" data-index-in-node=\"0\"\u003e3. Retinal Repair\u003c\/b\u003e\u003c\/h4\u003e\n\u003cp data-path-to-node=\"32\"\u003eInvestigated for its ability to restore retinal function in degenerative conditions like Retinitis Pigmentosa.\u003c\/p\u003e\n\u003cul data-path-to-node=\"33\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"33,0,0\"\u003e\u003cb data-path-to-node=\"33,0,0\" data-index-in-node=\"0\"\u003eFunctional Recovery:\u003c\/b\u003e In rat models, it preserved retinal structure and increased electroretinogram (ERG) amplitude by ~75%.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003chr data-path-to-node=\"34\"\u003e\n\u003ch3 data-path-to-node=\"35\"\u003e\u003cb data-path-to-node=\"35\" data-index-in-node=\"0\"\u003eStorage \u0026amp; Handling\u003c\/b\u003e\u003c\/h3\u003e\n\u003cul data-path-to-node=\"36\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"36,0,0\"\u003e\u003cb data-path-to-node=\"36,0,0\" data-index-in-node=\"0\"\u003ePhysical State:\u003c\/b\u003e Lyophilized (Freeze-Dried) Powder.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"36,1,0\"\u003e\u003cb data-path-to-node=\"36,1,0\" data-index-in-node=\"0\"\u003eStorage (Powder):\u003c\/b\u003e Store at -20°C (Freezer). Stable for up to 24 months.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"36,2,0\"\u003e\u003cb data-path-to-node=\"36,2,0\" data-index-in-node=\"0\"\u003eReconstitution:\u003c\/b\u003e\u003c\/p\u003e\n\u003cul data-path-to-node=\"36,2,1\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"36,2,1,0,0\"\u003e\u003cb data-path-to-node=\"36,2,1,0,0\" data-index-in-node=\"0\"\u003eSolvent:\u003c\/b\u003e Bacteriostatic Water or Sterile Saline.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"36,2,1,1,0\"\u003e\u003cb data-path-to-node=\"36,2,1,1,0\" data-index-in-node=\"0\"\u003eSolubility:\u003c\/b\u003e Highly hydrophilic and soluble.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"36,3,0\"\u003e\u003cb data-path-to-node=\"36,3,0\" data-index-in-node=\"0\"\u003eStorage (Liquid):\u003c\/b\u003e Store at 4°C (Refrigerator). Use within 14-21 days.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003chr data-path-to-node=\"37\"\u003e\n\u003ch3 data-path-to-node=\"38\"\u003e\u003cb data-path-to-node=\"38\" data-index-in-node=\"0\"\u003eDisclaimer\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp data-path-to-node=\"39\"\u003e\u003cb data-path-to-node=\"39\" data-index-in-node=\"0\"\u003eFOR RESEARCH USE ONLY.\u003c\/b\u003e This product is a chemical compound intended strictly for laboratory research and development. It is not approved by the FDA for clinical use, diagnostics, or therapeutic procedures in humans or animals. The physiological and toxicological properties of this chemical have not been fully investigated.\u003c\/p\u003e","brand":"Peptagon","offers":[{"title":"10mg","offer_id":47710043111638,"sku":"EPITH-10","price":31.0,"currency_code":"USD","in_stock":true},{"title":"50mg","offer_id":47710043144406,"sku":"EPITH-50","price":54.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0783\/3085\/5638\/files\/Epithalon-10mg.png?v=1768510212"},{"product_id":"foxo4-dri-foxo4-p53-research-peptide","title":"FOXO4-DRI Research Peptide – 15mg","description":"\u003ch4 data-path-to-node=\"13\"\u003e\u003cstrong\u003eFOXO4-DRI Peptide (Lyophilized)\u003c\/strong\u003e\u003c\/h4\u003e\n\u003cp data-path-to-node=\"14\"\u003e\u003cb data-path-to-node=\"14\" data-index-in-node=\"0\"\u003eSequence:\u003c\/b\u003e D-Retro-Inverso Sequence (53 Amino Acids) \u003cb data-path-to-node=\"14\" data-index-in-node=\"52\"\u003eFormat:\u003c\/b\u003e Sterile Lyophilized Powder (Vial) \u003cb data-path-to-node=\"14\" data-index-in-node=\"94\"\u003eMechanism:\u003c\/b\u003e FOXO4\/p53 Interaction Antagonist \u003cb data-path-to-node=\"14\" data-index-in-node=\"138\"\u003ePurity:\u003c\/b\u003e \u0026gt;98% (HPLC) \u003cb data-path-to-node=\"14\" data-index-in-node=\"158\"\u003eContent:\u003c\/b\u003e 15mg per vial\u003c\/p\u003e\n\u003chr data-path-to-node=\"15\"\u003e\n\u003ch3 data-path-to-node=\"16\"\u003e\u003cb data-path-to-node=\"16\" data-index-in-node=\"0\"\u003eProduct Overview\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp data-path-to-node=\"17\"\u003e\u003cb data-path-to-node=\"17\" data-index-in-node=\"0\"\u003eFOXO4-DRI\u003c\/b\u003e is a breakthrough \"third-generation\" senolytic peptide engineered to selectively eliminate senescent cells (\"zombie cells\") that accumulate with aging. Unlike earlier broad-spectrum senolytics that can harm healthy tissue, FOXO4-DRI targets a molecular interaction unique to senescent cells.\u003c\/p\u003e\n\u003cp data-path-to-node=\"18\"\u003eIt utilizes \u003cb data-path-to-node=\"18\" data-index-in-node=\"12\"\u003eD-Retro-Inverso (DRI)\u003c\/b\u003e chemistry, meaning it is composed of D-amino acids in a reverse sequence. This modification renders the peptide resistant to enzymatic degradation, significantly extending its half-life and potency in vivo compared to standard L-peptides.\u003c\/p\u003e\n\u003chr data-path-to-node=\"19\"\u003e\n\u003ch3 data-path-to-node=\"20\"\u003e\u003cb data-path-to-node=\"20\" data-index-in-node=\"0\"\u003eMechanism of Action: The \"Senescence Pivot\"\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp data-path-to-node=\"21\"\u003eFOXO4-DRI works by disrupting the specific protein-protein interaction that keeps senescent cells alive.\u003c\/p\u003e\n\u003cul data-path-to-node=\"22\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"22,0,0\"\u003e\u003cb data-path-to-node=\"22,0,0\" data-index-in-node=\"0\"\u003eTargeting the p53-FOXO4 Axis:\u003c\/b\u003e In senescent cells, the protein FOXO4 binds to p53 and sequesters it in the nucleus, preventing p53 from triggering cell death. This keeps the damaged cell in a state of suspended animation.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"22,1,0\"\u003e\u003cb data-path-to-node=\"22,1,0\" data-index-in-node=\"0\"\u003eCompetitive Displacement:\u003c\/b\u003e FOXO4-DRI mimics the binding site of FOXO4. It binds to p53 with high affinity, displacing the endogenous FOXO4.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"22,2,0\"\u003e\u003cb data-path-to-node=\"22,2,0\" data-index-in-node=\"0\"\u003eApoptosis Initiation:\u003c\/b\u003e Once liberated, p53 translocates to the mitochondria and activates BAX\/BAK, triggering intrinsic apoptosis (cell death) specifically in the senescent cell. Healthy cells, which do not have elevated FOXO4-p53 complexes, are left unharmed.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003chr data-path-to-node=\"23\"\u003e\n\u003ch3 data-path-to-node=\"24\"\u003e\u003cb data-path-to-node=\"24\" data-index-in-node=\"0\"\u003eKey Research Applications\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp data-path-to-node=\"25\"\u003e\u003cb data-path-to-node=\"25\" data-index-in-node=\"0\"\u003e1. Systemic Rejuvenation\u003c\/b\u003e In landmark studies (Baar et al.), FOXO4-DRI administration in aged mice reversed signs of frailty, restored fur density, and improved renal function by clearing senescent cells from tissues.\u003c\/p\u003e\n\u003cp data-path-to-node=\"26\"\u003e\u003cb data-path-to-node=\"26\" data-index-in-node=\"0\"\u003e2. Organ Fibrosis\u003c\/b\u003e Investigated for its ability to target senescent myofibroblasts in pulmonary and renal fibrosis models. By removing these \"scar-forming\" cells, it improves tissue architecture and reduces collagen deposition.\u003c\/p\u003e\n\u003cp data-path-to-node=\"27\"\u003e\u003cb data-path-to-node=\"27\" data-index-in-node=\"0\"\u003e3. Chemotoxicity Rescue\u003c\/b\u003e Chemotherapy (e.g., Doxorubicin) induces widespread cellular senescence. Research shows FOXO4-DRI can rescue liver function and prevent cachexia (weight loss) caused by chemotherapy-induced senescence.\u003c\/p\u003e\n\u003cp data-path-to-node=\"28\"\u003e\u003cb data-path-to-node=\"28\" data-index-in-node=\"0\"\u003e4. Endocrine Restoration\u003c\/b\u003e In models of hypogonadism, the peptide eliminated senescent Leydig cells in the testes, restoring natural testosterone production and enzymatic function in aged subjects.\u003c\/p\u003e\n\u003chr data-path-to-node=\"29\"\u003e\n\u003ch3 data-path-to-node=\"30\"\u003e\u003cb data-path-to-node=\"30\" data-index-in-node=\"0\"\u003eStorage \u0026amp; Handling\u003c\/b\u003e\u003c\/h3\u003e\n\u003cul data-path-to-node=\"31\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"31,0,0\"\u003e\u003cb data-path-to-node=\"31,0,0\" data-index-in-node=\"0\"\u003ePhysical State:\u003c\/b\u003e Lyophilized (Freeze-Dried) Powder.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"31,1,0\"\u003e\u003cb data-path-to-node=\"31,1,0\" data-index-in-node=\"0\"\u003eStorage (Powder):\u003c\/b\u003e Store at -20°C (Freezer). Stable for up to 36 months.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"31,2,0\"\u003e\u003cb data-path-to-node=\"31,2,0\" data-index-in-node=\"0\"\u003eReconstitution:\u003c\/b\u003e\u003c\/p\u003e\n\u003cul data-path-to-node=\"31,2,1\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"31,2,1,0,0\"\u003e\u003cb data-path-to-node=\"31,2,1,0,0\" data-index-in-node=\"0\"\u003eSolvent:\u003c\/b\u003e Sterile PBS or Saline.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"31,2,1,1,0\"\u003e\u003cb data-path-to-node=\"31,2,1,1,0\" data-index-in-node=\"0\"\u003eSolubility:\u003c\/b\u003e Highly soluble due to cationic residues.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"31,3,0\"\u003e\u003cb data-path-to-node=\"31,3,0\" data-index-in-node=\"0\"\u003eStorage (Liquid):\u003c\/b\u003e Store at 4°C. \u003cb data-path-to-node=\"31,3,0\" data-index-in-node=\"32\"\u003eUse within 2-4 weeks.\u003c\/b\u003e The DRI modification improves stability, but reconstituted peptides naturally degrade over time.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003chr data-path-to-node=\"32\"\u003e\n\u003ch3 data-path-to-node=\"33\"\u003e\u003cb data-path-to-node=\"33\" data-index-in-node=\"0\"\u003eDisclaimer\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp data-path-to-node=\"34\"\u003e\u003cb data-path-to-node=\"34\" data-index-in-node=\"0\"\u003eFOR RESEARCH USE ONLY.\u003c\/b\u003e This product is a chemical compound intended strictly for laboratory research and development. It is not approved by the FDA for clinical use, diagnostics, or therapeutic procedures in humans or animals. The physiological and toxicological properties of this chemical have not been fully investigated.\u003c\/p\u003e","brand":"Peptagon","offers":[{"title":"Default Title","offer_id":47710043635926,"sku":"FOXO4-DRI-15","price":100.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0783\/3085\/5638\/files\/FOXO4-DRI-15mg.png?v=1768510316"},{"product_id":"pe-22-28-trek-1-research-peptide","title":"PE-22-28 Research Peptide – 10mg","description":"\u003ch4 data-path-to-node=\"13\"\u003e\u003cstrong\u003ePE-22-28 Peptide (Lyophilized)\u003c\/strong\u003e\u003c\/h4\u003e\n\u003cp data-path-to-node=\"14\"\u003e\u003cb data-path-to-node=\"14\" data-index-in-node=\"0\"\u003eSequence:\u003c\/b\u003e Gly-Val-Ser-Trp-Gly-Leu-Arg (GVSWGLR) \u003cb data-path-to-node=\"14\" data-index-in-node=\"48\"\u003eFormat:\u003c\/b\u003e Sterile Lyophilized Powder (Vial) \u003cb data-path-to-node=\"14\" data-index-in-node=\"90\"\u003eTarget:\u003c\/b\u003e TREK-1 Potassium Channel Inhibitor \u003cb data-path-to-node=\"14\" data-index-in-node=\"133\"\u003ePurity:\u003c\/b\u003e \u0026gt;98% (HPLC) \u003cb data-path-to-node=\"14\" data-index-in-node=\"153\"\u003eContent:\u003c\/b\u003e 10mg per vial\u003c\/p\u003e\n\u003chr data-path-to-node=\"15\"\u003e\n\u003ch3 data-path-to-node=\"16\"\u003e\u003cb data-path-to-node=\"16\" data-index-in-node=\"0\"\u003eProduct Overview\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp data-path-to-node=\"17\"\u003e\u003cb data-path-to-node=\"17\" data-index-in-node=\"0\"\u003ePE-22-28\u003c\/b\u003e is a synthetic heptapeptide derived from the endogenous protein Spadin (Sortilin). It is a highly potent inhibitor of the \u003cb data-path-to-node=\"17\" data-index-in-node=\"131\"\u003eTREK-1 (TWIK-related potassium channel-1)\u003c\/b\u003e ion channel.\u003c\/p\u003e\n\u003cp data-path-to-node=\"18\"\u003eUnlike traditional antidepressants that target serotonin reuptake (SSRIs), PE-22-28 works downstream by modulating neuronal excitability directly. It acts as a \"neuroplasticity catalyst,\" promoting the growth of new neurons (neurogenesis) and synapses (synaptogenesis) in the hippocampus and prefrontal cortex. It is investigated for its ability to produce rapid antidepressant effects in \u003cb data-path-to-node=\"18\" data-index-in-node=\"389\"\u003e4 days\u003c\/b\u003e, compared to the 3-4 weeks required for standard therapies.\u003c\/p\u003e\n\u003chr data-path-to-node=\"19\"\u003e\n\u003ch3 data-path-to-node=\"20\"\u003e\u003cb data-path-to-node=\"20\" data-index-in-node=\"0\"\u003eMechanism of Action: The TREK-1 Blockade\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp data-path-to-node=\"21\"\u003ePE-22-28 functions by blocking the background \"leak\" current of potassium ions in neurons.\u003c\/p\u003e\n\u003cul data-path-to-node=\"22\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"22,0,0\"\u003e\u003cb data-path-to-node=\"22,0,0\" data-index-in-node=\"0\"\u003eDepolarization:\u003c\/b\u003e By inhibiting TREK-1, it slightly depolarizes neurons, making them more excitable and ready to fire. This increases the activity of serotonergic neurons in the Dorsal Raphe Nucleus without the lag of autoreceptor desensitization.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"22,1,0\"\u003e\u003cb data-path-to-node=\"22,1,0\" data-index-in-node=\"0\"\u003eNeurotrophic Signaling:\u003c\/b\u003e The depolarization triggers calcium influx, activating the \u003cb data-path-to-node=\"22,1,0\" data-index-in-node=\"83\"\u003eCREB\u003c\/b\u003e transcription factor. This leads to the rapid expression of \u003cb data-path-to-node=\"22,1,0\" data-index-in-node=\"148\"\u003eBDNF (Brain-Derived Neurotrophic Factor)\u003c\/b\u003e, the key driver of neuronal growth and survival.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"22,2,0\"\u003e\u003cb data-path-to-node=\"22,2,0\" data-index-in-node=\"0\"\u003eSynaptogenesis:\u003c\/b\u003e Increases the density of \u003cb data-path-to-node=\"22,2,0\" data-index-in-node=\"41\"\u003ePSD-95\u003c\/b\u003e, a marker of mature, functional synapses, restoring connectivity in depressed or damaged brain circuits.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003chr data-path-to-node=\"23\"\u003e\n\u003ch3 data-path-to-node=\"24\"\u003e\u003cb data-path-to-node=\"24\" data-index-in-node=\"0\"\u003eKey Research Applications\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp data-path-to-node=\"25\"\u003e\u003cb data-path-to-node=\"25\" data-index-in-node=\"0\"\u003e1. Rapid-Acting Antidepressant\u003c\/b\u003e PE-22-28 is the benchmark for researching rapid mood recovery. Preclinical studies show it reduces immobility (depression-like behavior) and anxiety within \u003cb data-path-to-node=\"25\" data-index-in-node=\"187\"\u003e4 days\u003c\/b\u003e, offering a potential alternative to slow-acting monoaminergic drugs.\u003c\/p\u003e\n\u003cp data-path-to-node=\"26\"\u003e\u003cb data-path-to-node=\"26\" data-index-in-node=\"0\"\u003e2. Stroke Recovery \u0026amp; Neuroprotection\u003c\/b\u003e Investigated for its biphasic role in stroke:\u003c\/p\u003e\n\u003cul data-path-to-node=\"27\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"27,0,0\"\u003e\u003cb data-path-to-node=\"27,0,0\" data-index-in-node=\"0\"\u003eAcute Phase:\u003c\/b\u003e Low doses may offer neuroprotection.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"27,1,0\"\u003e\u003cb data-path-to-node=\"27,1,0\" data-index-in-node=\"0\"\u003eChronic Phase:\u003c\/b\u003e High doses stimulate neurogenesis, improving motor coordination and memory recovery weeks after ischemic injury.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp data-path-to-node=\"28\"\u003e\u003cb data-path-to-node=\"28\" data-index-in-node=\"0\"\u003e3. Cognitive Enhancement\u003c\/b\u003e By promoting synaptic plasticity and hippocampal neurogenesis, PE-22-28 is studied for its ability to improve spatial memory and learning capabilities in models of cognitive decline.\u003c\/p\u003e\n\u003chr data-path-to-node=\"29\"\u003e\n\u003ch3 data-path-to-node=\"30\"\u003e\u003cb data-path-to-node=\"30\" data-index-in-node=\"0\"\u003eStorage \u0026amp; Handling\u003c\/b\u003e\u003c\/h3\u003e\n\u003cul data-path-to-node=\"31\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"31,0,0\"\u003e\u003cb data-path-to-node=\"31,0,0\" data-index-in-node=\"0\"\u003ePhysical State:\u003c\/b\u003e Lyophilized (Freeze-Dried) White Powder.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"31,1,0\"\u003e\u003cb data-path-to-node=\"31,1,0\" data-index-in-node=\"0\"\u003eStorage (Powder):\u003c\/b\u003e Store at -20°C (Freezer). Stable for up to 24 months.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"31,2,0\"\u003e\u003cb data-path-to-node=\"31,2,0\" data-index-in-node=\"0\"\u003eReconstitution:\u003c\/b\u003e\u003c\/p\u003e\n\u003cul data-path-to-node=\"31,2,1\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"31,2,1,0,0\"\u003e\u003cb data-path-to-node=\"31,2,1,0,0\" data-index-in-node=\"0\"\u003eSolvent:\u003c\/b\u003e Sterile Water or Saline.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"31,2,1,1,0\"\u003e\u003cb data-path-to-node=\"31,2,1,1,0\" data-index-in-node=\"0\"\u003eSolubility:\u003c\/b\u003e Highly soluble.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"31,3,0\"\u003e\u003cb data-path-to-node=\"31,3,0\" data-index-in-node=\"0\"\u003eStorage (Liquid):\u003c\/b\u003e Store at 4°C (Refrigerator). Use within 14-21 days.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003chr data-path-to-node=\"32\"\u003e\n\u003ch3 data-path-to-node=\"33\"\u003e\u003cb data-path-to-node=\"33\" data-index-in-node=\"0\"\u003eDisclaimer\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp data-path-to-node=\"34\"\u003e\u003cb data-path-to-node=\"34\" data-index-in-node=\"0\"\u003eFOR RESEARCH USE ONLY.\u003c\/b\u003e This product is a chemical compound intended strictly for laboratory research and development. It is not approved by the FDA for clinical use, diagnostics, or therapeutic procedures in humans or animals. The physiological and toxicological properties of this chemical have not been fully investigated.\u003c\/p\u003e","brand":"Peptagon","offers":[{"title":"Default Title","offer_id":47712433406166,"sku":"PE2228-10","price":32.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0783\/3085\/5638\/files\/PE-22-28-10mmg.png?v=1768510335"},{"product_id":"dihexa-pnb-0408-hgf-c-met-research-tablets","title":"Dihexa Research Tablets – 8mg \/ 30mg – 30 Count","description":"\u003ch4 data-path-to-node=\"11\"\u003e\u003cstrong\u003eDihexa: The Synaptogenic Catalyst\u003c\/strong\u003e\u003c\/h4\u003e\n\u003cp data-path-to-node=\"12\"\u003e\u003cb data-path-to-node=\"12\" data-index-in-node=\"0\"\u003eCore Molecule:\u003c\/b\u003e N-hexanoic-tyrosine-isoleucine-(6) aminohexanoic amide \u003cb data-path-to-node=\"12\" data-index-in-node=\"70\"\u003eFormat:\u003c\/b\u003e Oral Tablets \u003cb data-path-to-node=\"12\" data-index-in-node=\"91\"\u003eClass:\u003c\/b\u003e HGF Mimetic \/ Neurorestorative Peptide \u003cb data-path-to-node=\"12\" data-index-in-node=\"137\"\u003ePurity:\u003c\/b\u003e ≥98% (HPLC) \u003cb data-path-to-node=\"12\" data-index-in-node=\"157\"\u003eTarget:\u003c\/b\u003e HGF\/c-Met Signaling Pathway\u003c\/p\u003e\n\u003chr data-path-to-node=\"13\"\u003e\n\u003ch3 data-path-to-node=\"14\"\u003e\u003cb data-path-to-node=\"14\" data-index-in-node=\"0\"\u003eProduct Overview\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp data-path-to-node=\"15\"\u003e\u003cb data-path-to-node=\"15\" data-index-in-node=\"0\"\u003eDihexa (PNB-0408)\u003c\/b\u003e is a first-in-class, orally active oligopeptide designed to repair and rebuild neural architecture. Originally developed as a stabilized analog of Angiotensin IV, Dihexa was engineered to overcome the blood-brain barrier (BBB) and provide a regenerative approach to neurological decline.\u003c\/p\u003e\n\u003cp data-path-to-node=\"16\"\u003eDihexa is widely recognized for its \"synaptogenic\" properties—the ability to create new, functional connections between neurons. Unlike traditional agents that merely manage symptoms, Dihexa targets the underlying loss of connectivity in the brain, making it a premier candidate for research into Alzheimer’s disease, Parkinson’s disease, and traumatic brain injury.\u003c\/p\u003e\n\u003chr data-path-to-node=\"17\"\u003e\n\u003ch3 data-path-to-node=\"18\"\u003e\u003cb data-path-to-node=\"18\" data-index-in-node=\"0\"\u003eMechanism of Action: Rebuilding the Neural Web\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp data-path-to-node=\"19\"\u003eDihexa operates by potentiation of the \u003cb data-path-to-node=\"19\" data-index-in-node=\"39\"\u003eHepatocyte Growth Factor (HGF)\u003c\/b\u003e and its receptor, \u003cb data-path-to-node=\"19\" data-index-in-node=\"88\"\u003ec-Met\u003c\/b\u003e.\u003c\/p\u003e\n\u003cul data-path-to-node=\"20\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"20,0,0\"\u003e\u003cb data-path-to-node=\"20,0,0\" data-index-in-node=\"0\"\u003eSynaptogenesis:\u003c\/b\u003e By allosterically modulating HGF, Dihexa triggers the \u003cb data-path-to-node=\"20,0,0\" data-index-in-node=\"70\"\u003ePI3K\/AKT\u003c\/b\u003e and \u003cb data-path-to-node=\"20,0,0\" data-index-in-node=\"83\"\u003eMAPK\/ERK\u003c\/b\u003e pathways. This initiates the formation of new dendritic spines and functional synapses.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"20,1,0\"\u003e\u003cb data-path-to-node=\"20,1,0\" data-index-in-node=\"0\"\u003eExceptional Potency:\u003c\/b\u003e In laboratory assays, Dihexa demonstrated a neurotrophic potency \u003cb data-path-to-node=\"20,1,0\" data-index-in-node=\"86\"\u003eseven orders of magnitude (10^7 times) greater than BDNF\u003c\/b\u003e (Brain-Derived Neurotrophic Factor).\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"20,2,0\"\u003e\u003cb data-path-to-node=\"20,2,0\" data-index-in-node=\"0\"\u003eStructural Maturity:\u003c\/b\u003e It promotes the development of mature \"mushroom\" spine morphologies, which are associated with stable, long-term memory storage and robust neurotransmission.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"20,3,0\"\u003e\u003cb data-path-to-node=\"20,3,0\" data-index-in-node=\"0\"\u003eNeuroprotection:\u003c\/b\u003e It reduces neuroinflammation by decreasing astrocyte and microglia activation while increasing anti-inflammatory cytokines like IL-10.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003chr data-path-to-node=\"21\"\u003e\n\u003ch3 data-path-to-node=\"22\"\u003e\u003cb data-path-to-node=\"22\" data-index-in-node=\"0\"\u003eKey Research Applications\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp data-path-to-node=\"23\"\u003e\u003cb data-path-to-node=\"23\" data-index-in-node=\"0\"\u003e1. Alzheimer’s \u0026amp; Cognitive Decline\u003c\/b\u003e Investigated for its ability to rescue cognitive function. In APP\/PS1 mouse models, Dihexa significantly improved spatial learning and learning memory, returning performance to levels indistinguishable from healthy controls.\u003c\/p\u003e\n\u003cp data-path-to-node=\"24\"\u003e\u003cb data-path-to-node=\"24\" data-index-in-node=\"0\"\u003e2. Parkinson’s \u0026amp; Motor Recovery\u003c\/b\u003e Research supported by the Michael J. Fox Foundation showed that Dihexa can completely restore motor function in preclinical models of Parkinson's by promoting the survival of dopaminergic neurons and recovering Tyrosine Hydroxylase (TH) levels.\u003c\/p\u003e\n\u003cp data-path-to-node=\"25\"\u003e\u003cb data-path-to-node=\"25\" data-index-in-node=\"0\"\u003e3. Peripheral Nerve Repair\u003c\/b\u003e Studies demonstrate that Dihexa accelerates recovery from peripheral nerve injuries (PNI), enhancing motor reinnervation and mitigating muscle atrophy following nerve transection.\u003c\/p\u003e\n\u003chr data-path-to-node=\"26\"\u003e\n\u003ch3 data-path-to-node=\"27\"\u003e\u003cb data-path-to-node=\"27\" data-index-in-node=\"0\"\u003eStorage \u0026amp; Handling\u003c\/b\u003e\u003c\/h3\u003e\n\u003cul data-path-to-node=\"28\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"28,0,0\"\u003e\u003cb data-path-to-node=\"28,0,0\" data-index-in-node=\"0\"\u003ePhysical State:\u003c\/b\u003e Tablet form for consistent oral research protocols.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"28,1,0\"\u003e\u003cb data-path-to-node=\"28,1,0\" data-index-in-node=\"0\"\u003eStorage:\u003c\/b\u003e Store in a cool, dry place.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"28,2,0\"\u003e\u003cb data-path-to-node=\"28,2,0\" data-index-in-node=\"0\"\u003eLong-Term Storage:\u003c\/b\u003e Store at -20°C (Freezer) to maintain maximum purity and resist peptidase degradation.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"28,3,0\"\u003e\u003cb data-path-to-node=\"28,3,0\" data-index-in-node=\"0\"\u003eStability:\u003c\/b\u003e Highly stable and resistant to the harsh environment of the gastrointestinal tract.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003chr data-path-to-node=\"29\"\u003e\n\u003ch3 data-path-to-node=\"30\"\u003e\u003cb data-path-to-node=\"30\" data-index-in-node=\"0\"\u003eDisclaimer\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp data-path-to-node=\"31\"\u003e\u003cb data-path-to-node=\"31\" data-index-in-node=\"0\"\u003eFOR RESEARCH USE ONLY.\u003c\/b\u003e This product is a chemical compound intended strictly for laboratory research and development. It is not approved by the FDA for clinical use, diagnostics, or therapeutic procedures in humans or animals. The physiological and toxicological properties of this chemical have not been fully investigated.\u003c\/p\u003e","brand":"Peptagon","offers":[{"title":"8mg","offer_id":48169997598934,"sku":"DIHEX-8x30","price":92.0,"currency_code":"USD","in_stock":true},{"title":"30mg","offer_id":48169997631702,"sku":null,"price":206.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0783\/3085\/5638\/files\/Dihexa-_8mg_-x-30-Tablets.png?v=1768837429"},{"product_id":"brain-blend-dihexa-tesofensine-bpc-157-research-tablets","title":"Dihexa + Tesofensine + BPC-157 Research Tablets – 10mg \/ 250mcg \/ 125mcg – 60 Count","description":"\u003ch4 data-path-to-node=\"11\"\u003e\u003cstrong\u003eThe Brain Blend: Neuro-Regenerative Ecosystem\u003c\/strong\u003e\u003c\/h4\u003e\n\u003cp data-path-to-node=\"12\"\u003e\u003cb data-path-to-node=\"12\" data-index-in-node=\"0\"\u003eComposition:\u003c\/b\u003e Dihexa (10mg) \/ Tesofensine (250mcg) \/ BPC-157 (125mcg) \u003cb data-path-to-node=\"12\" data-index-in-node=\"69\"\u003eFormat:\u003c\/b\u003e Oral Formulation (Research Grade) \u003cb data-path-to-node=\"12\" data-index-in-node=\"111\"\u003eClass:\u003c\/b\u003e Multi-Modal Nootropic \u0026amp; Synaptogenic Stack \u003cb data-path-to-node=\"12\" data-index-in-node=\"161\"\u003eTarget:\u003c\/b\u003e HGF\/c-Met Signaling, Triple Monoamine Reuptake, VEGFR2 Angiogenesis\u003c\/p\u003e\n\u003chr data-path-to-node=\"13\"\u003e\n\u003ch3 data-path-to-node=\"14\"\u003e\u003cb data-path-to-node=\"14\" data-index-in-node=\"0\"\u003eProduct Overview\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp data-path-to-node=\"15\"\u003e\u003cb data-path-to-node=\"15\" data-index-in-node=\"0\"\u003eThe Brain Blend\u003c\/b\u003e is a high-level research formulation designed to address the structural, functional, and systemic layers of cognitive health. By integrating three distinct pharmacological classes, this stack moves beyond simple neurotransmitter temporary boosting to focus on the physical reconstruction of the brain's neural networks.\u003c\/p\u003e\n\u003cp data-path-to-node=\"16\"\u003eThis blend targets the \"Architectural Triad\" of the central nervous system:\u003c\/p\u003e\n\u003col start=\"1\" data-path-to-node=\"17\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"17,0,0\"\u003e\u003cb data-path-to-node=\"17,0,0\" data-index-in-node=\"0\"\u003eStructural:\u003c\/b\u003e Rebuilding physical connections (Dihexa).\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"17,1,0\"\u003e\u003cb data-path-to-node=\"17,1,0\" data-index-in-node=\"0\"\u003eFunctional:\u003c\/b\u003e Optimizing signaling and neurotransmission (Tesofensine).\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"17,2,0\"\u003e\u003cb data-path-to-node=\"17,2,0\" data-index-in-node=\"0\"\u003eEnvironmental:\u003c\/b\u003e Ensuring vascular integrity and inflammatory stability (BPC-157).\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ol\u003e\n\u003chr data-path-to-node=\"18\"\u003e\n\u003ch3 data-path-to-node=\"19\"\u003e\u003cb data-path-to-node=\"19\" data-index-in-node=\"0\"\u003eMechanism of Action: The Highway and Traffic Paradigm\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp data-path-to-node=\"20\"\u003eThe Brain Blend utilizes a \"highway and traffic\" model for neural optimization:\u003c\/p\u003e\n\u003cul data-path-to-node=\"21\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"21,0,0\"\u003e\u003cb data-path-to-node=\"21,0,0\" data-index-in-node=\"0\"\u003eDihexa (The Road Builder):\u003c\/b\u003e A picomolar-potency HGF mimetic that is approximately seven million times more powerful than BDNF. It drives \u003cb data-path-to-node=\"21,0,0\" data-index-in-node=\"136\"\u003esynaptogenesis\u003c\/b\u003e (the creation of new synapses) and dendritic arborization by activating the c-Met receptor. This effectively \"rebuilds the highways\" of the brain.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"21,1,0\"\u003e\u003cb data-path-to-node=\"21,1,0\" data-index-in-node=\"0\"\u003eTesofensine (The Traffic Controller):\u003c\/b\u003e A triple monoamine reuptake inhibitor (SNDRI) that elevates serotonin, dopamine, and norepinephrine. It sharpens focus, enhances satiety, and increases metabolic expenditure, ensuring that the \"traffic\" on the newly built neural highways is optimized for speed and efficiency.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"21,2,0\"\u003e\u003cb data-path-to-node=\"21,2,0\" data-index-in-node=\"0\"\u003eBPC-157 (The Environmental Stabilizer):\u003c\/b\u003e A gastric-derived pentadecapeptide that promotes \u003cb data-path-to-node=\"21,2,0\" data-index-in-node=\"89\"\u003eangiogenesis\u003c\/b\u003e via the VEGFR2 pathway. It ensures a robust blood supply to support new neural structures while balancing the GABA and Dopamine systems to prevent overstimulation and neuroinflammation.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003chr data-path-to-node=\"22\"\u003e\n\u003ch3 data-path-to-node=\"23\"\u003e\u003cb data-path-to-node=\"23\" data-index-in-node=\"0\"\u003eKey Research Applications\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp data-path-to-node=\"24\"\u003e\u003cb data-path-to-node=\"24\" data-index-in-node=\"0\"\u003e1. Synaptic Density \u0026amp; Cognitive Repair\u003c\/b\u003e Investigated for its ability to reverse scopolamine-induced amnesia and age-related cognitive decline. Research shows Dihexa can increase hippocampal spine density by up to 3-fold, creating a physical foundation for improved memory.\u003c\/p\u003e\n\u003cp data-path-to-node=\"25\"\u003e\u003cb data-path-to-node=\"25\" data-index-in-node=\"0\"\u003e2. Metabolic Resilience \u0026amp; Satiety\u003c\/b\u003e Tesofensine is studied for its dual-action as an appetite suppressant and metabolic stimulator. In clinical research, it has achieved significantly higher weight loss percentages than standard agents by modulating the lateral hypothalamus.\u003c\/p\u003e\n\u003cp data-path-to-node=\"26\"\u003e\u003cb data-path-to-node=\"26\" data-index-in-node=\"0\"\u003e3. Neuroprotection \u0026amp; Stroke Recovery\u003c\/b\u003e The inclusion of BPC-157 makes this blend a candidate for research into brain lesion repair. Studies indicate BPC-157 can resolve hippocampal damage following ischemic insult and normalize neurotransmitter imbalances during pharmacological stress.\u003c\/p\u003e\n\u003chr data-path-to-node=\"27\"\u003e\n\u003ch3 data-path-to-node=\"28\"\u003e\u003cb data-path-to-node=\"28\" data-index-in-node=\"0\"\u003eStorage \u0026amp; Handling\u003c\/b\u003e\u003c\/h3\u003e\n\u003cul data-path-to-node=\"29\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"29,0,0\"\u003e\u003cb data-path-to-node=\"29,0,0\" data-index-in-node=\"0\"\u003ePhysical State:\u003c\/b\u003e Specialized oral research formulation.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"29,1,0\"\u003e\u003cb data-path-to-node=\"29,1,0\" data-index-in-node=\"0\"\u003eStorage:\u003c\/b\u003e Store in a cool, dry place away from direct sunlight.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"29,2,0\"\u003e\u003cb data-path-to-node=\"29,2,0\" data-index-in-node=\"0\"\u003eLong-Term Storage:\u003c\/b\u003e Store at -20°C (Freezer) to maintain maximum stability of the HGF mimetics and SNDRI components.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"29,3,0\"\u003e\u003cb data-path-to-node=\"29,3,0\" data-index-in-node=\"0\"\u003eStability:\u003c\/b\u003e Dihexa is exceptionally stable; however, Tesofensine requires protection from moisture to prevent degradation.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003chr data-path-to-node=\"30\"\u003e\n\u003ch3 data-path-to-node=\"31\"\u003e\u003cb data-path-to-node=\"31\" data-index-in-node=\"0\"\u003eDisclaimer\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp data-path-to-node=\"32\"\u003e\u003cb data-path-to-node=\"32\" data-index-in-node=\"0\"\u003eFOR RESEARCH USE ONLY.\u003c\/b\u003e This product is a chemical compound intended strictly for laboratory research and development. It is not approved by the FDA for clinical use, diagnostics, or therapeutic procedures in humans or animals. The physiological and toxicological properties of this chemical have not been fully investigated.\u003c\/p\u003e","brand":"Peptagon","offers":[{"title":"Default Title","offer_id":47712709935318,"sku":"DIH-TESO-BPC-10-25-125x60","price":157.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0783\/3085\/5638\/files\/Brain-Blend-Dihexa_10mg_-Tesofensine_250mcg_-BPC-157_125mcg_x60Tablets.png?v=1768837472"}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0783\/3085\/5638\/collections\/Cellular_Signaling_Research_Collection.png?v=1781104225","url":"https:\/\/peptagon.com\/collections\/cellular-signaling-research.oembed","provider":"Peptagon","version":"1.0","type":"link"}