{"title":"Endocrine Pathway Research","description":"\u003cp\u003eThis collection includes research peptides studied in laboratory models involving endocrine signaling, receptor pathway activity, neuroendocrine regulation, and related cellular communication systems.\u003c\/p\u003e\n\u003cp\u003eProducts in this collection are organized for research cataloging purposes only and are intended strictly for laboratory research use. They are not dietary supplements, medications, cosmetics, or consumer health products, and are not for human or veterinary use.\u003c\/p\u003e","products":[{"product_id":"gonadorelin-acetate-gnrh-research-peptide","title":"Gonadorelin Research Peptide – 5mg \/ 10mg","description":"\u003ch4 data-path-to-node=\"13\"\u003e\u003cstrong\u003eGonadorelin (GnRH) Peptide (Lyophilized)\u003c\/strong\u003e\u003c\/h4\u003e\n\u003cp data-path-to-node=\"14\"\u003e\u003cb data-path-to-node=\"14\" data-index-in-node=\"0\"\u003eSequence:\u003c\/b\u003e pGlu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH2 \u003cb data-path-to-node=\"14\" data-index-in-node=\"55\"\u003eFormat:\u003c\/b\u003e Sterile Lyophilized Powder (Vial) \u003cb data-path-to-node=\"14\" data-index-in-node=\"97\"\u003eClass:\u003c\/b\u003e Gonadotropin-Releasing Hormone Agonist \u003cb data-path-to-node=\"14\" data-index-in-node=\"143\"\u003ePurity:\u003c\/b\u003e \u0026gt;98% (HPLC) \u003cb data-path-to-node=\"14\" data-index-in-node=\"163\"\u003eContent:\u003c\/b\u003e Available in 5mg and 10mg vials\u003c\/p\u003e\n\u003chr data-path-to-node=\"15\"\u003e\n\u003ch3 data-path-to-node=\"16\"\u003e\u003cb data-path-to-node=\"16\" data-index-in-node=\"0\"\u003eProduct Overview\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp data-path-to-node=\"17\"\u003e\u003cb data-path-to-node=\"17\" data-index-in-node=\"0\"\u003eGonadorelin\u003c\/b\u003e is the synthetic acetate salt of the endogenous decapeptide Gonadotropin-Releasing Hormone (GnRH). It serves as the primary neural integrator of the hypothalamic-pituitary-gonadal (HPG) axis.\u003c\/p\u003e\n\u003cp data-path-to-node=\"18\"\u003eThis peptide functions as a \"pulse decoder.\" The frequency and amplitude of Gonadorelin pulses determine the differential secretion of \u003cb data-path-to-node=\"18\" data-index-in-node=\"135\"\u003eLuteinizing Hormone (LH)\u003c\/b\u003e and \u003cb data-path-to-node=\"18\" data-index-in-node=\"164\"\u003eFollicle-Stimulating Hormone (FSH)\u003c\/b\u003e from the pituitary gland. The 5mg and 10mg high-concentration vials are specifically designed for large-scale veterinary research (herd synchronization) and high-throughput pharmacological screening.\u003c\/p\u003e\n\u003chr data-path-to-node=\"19\"\u003e\n\u003ch3 data-path-to-node=\"20\"\u003e\u003cb data-path-to-node=\"20\" data-index-in-node=\"0\"\u003eMechanism of Action: The Pulse Decoder\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp data-path-to-node=\"21\"\u003eGonadorelin binds to the \u003cb data-path-to-node=\"21\" data-index-in-node=\"25\"\u003eGnRHR\u003c\/b\u003e (G protein-coupled receptor) on pituitary gonadotrophs, activating the Gq\/11-Phospholipase C pathway.\u003c\/p\u003e\n\u003cul data-path-to-node=\"22\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"22,0,0\"\u003e\u003cb data-path-to-node=\"22,0,0\" data-index-in-node=\"0\"\u003ePulse Frequency Coding:\u003c\/b\u003e\u003c\/p\u003e\n\u003cul data-path-to-node=\"22,0,1\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"22,0,1,0,0\"\u003e\u003cb data-path-to-node=\"22,0,1,0,0\" data-index-in-node=\"0\"\u003eHigh Frequency (~30 min):\u003c\/b\u003e Activates the \u003cb data-path-to-node=\"22,0,1,0,0\" data-index-in-node=\"40\"\u003eMAPK\/EGR1\u003c\/b\u003e pathway, preferentially stimulating \u003cb data-path-to-node=\"22,0,1,0,0\" data-index-in-node=\"86\"\u003eLH\u003c\/b\u003e synthesis (essential for ovulation).\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"22,0,1,1,0\"\u003e\u003cb data-path-to-node=\"22,0,1,1,0\" data-index-in-node=\"0\"\u003eLow Frequency (~120 min):\u003c\/b\u003e Activates the \u003cb data-path-to-node=\"22,0,1,1,0\" data-index-in-node=\"40\"\u003ecAMP\/CREB\u003c\/b\u003e pathway, preferentially stimulating \u003cb data-path-to-node=\"22,0,1,1,0\" data-index-in-node=\"86\"\u003eFSH\u003c\/b\u003e synthesis (essential for follicular growth).\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"22,1,0\"\u003e\u003cb data-path-to-node=\"22,1,0\" data-index-in-node=\"0\"\u003eCalcium Mobilization:\u003c\/b\u003e Triggers a massive influx of intracellular calcium via IP3, driving the exocytosis of stored gonadotropins.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003chr data-path-to-node=\"23\"\u003e\n\u003ch3 data-path-to-node=\"24\"\u003e\u003cb data-path-to-node=\"24\" data-index-in-node=\"0\"\u003eKey Research Applications\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp data-path-to-node=\"25\"\u003e\u003cb data-path-to-node=\"25\" data-index-in-node=\"0\"\u003e1. Veterinary \u0026amp; Herd Management (Ovsynch)\u003c\/b\u003e In dairy and livestock research, Gonadorelin is the cornerstone of estrus synchronization protocols.\u003c\/p\u003e\n\u003cul data-path-to-node=\"26\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"26,0,0\"\u003e\u003cb data-path-to-node=\"26,0,0\" data-index-in-node=\"0\"\u003eCystic Ovaries:\u003c\/b\u003e High-dose bolus administration induces the LH surge required to luteinize follicular cysts.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"26,1,0\"\u003e\u003cb data-path-to-node=\"26,1,0\" data-index-in-node=\"0\"\u003eFTAI:\u003c\/b\u003e Used in \"Ovsynch\" protocols to synchronize ovulation across a herd, allowing for Fixed-Time Artificial Insemination without the need for estrus detection.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp data-path-to-node=\"27\"\u003e\u003cb data-path-to-node=\"27\" data-index-in-node=\"0\"\u003e2. Endocrine Diagnostics\u003c\/b\u003e Used as a diagnostic probe to assess pituitary function. The \u003cb data-path-to-node=\"27\" data-index-in-node=\"86\"\u003eGonadorelin Stimulation Test\u003c\/b\u003e differentiates between hypothalamic dysfunction (where the pituitary is intact but lacks signal) and pituitary failure.\u003c\/p\u003e\n\u003cp data-path-to-node=\"28\"\u003e\u003cb data-path-to-node=\"28\" data-index-in-node=\"0\"\u003e3. Reproductive Physiology\u003c\/b\u003e Investigated for its ability to restore pulsatile secretion in conditions like Hypothalamic Amenorrhea or Kallmann Syndrome, bypassing the need for exogenous gonadotropins.\u003c\/p\u003e\n\u003chr data-path-to-node=\"29\"\u003e\n\u003ch3 data-path-to-node=\"30\"\u003e\u003cb data-path-to-node=\"30\" data-index-in-node=\"0\"\u003eComparison: Gonadorelin vs. CJC-1295\u003c\/b\u003e\u003c\/h3\u003e\n\u003cul data-path-to-node=\"31\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"31,0,0\"\u003e\u003cb data-path-to-node=\"31,0,0\" data-index-in-node=\"0\"\u003eGonadorelin:\u003c\/b\u003e Native decapeptide. Half-life of \u003cb data-path-to-node=\"31,0,0\" data-index-in-node=\"46\"\u003e2-4 minutes\u003c\/b\u003e. Used for \u003cb data-path-to-node=\"31,0,0\" data-index-in-node=\"68\"\u003epulsatile\u003c\/b\u003e stimulation of the reproductive axis (LH\/FSH).\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"31,1,0\"\u003e\u003cb data-path-to-node=\"31,1,0\" data-index-in-node=\"0\"\u003eCJC-1295 (DAC):\u003c\/b\u003e Modified GHRH analog. Half-life of \u003cb data-path-to-node=\"31,1,0\" data-index-in-node=\"51\"\u003e6-8 days\u003c\/b\u003e. Used for \u003cb data-path-to-node=\"31,1,0\" data-index-in-node=\"70\"\u003esustained\u003c\/b\u003e stimulation of the somatotropic axis (GH\/IGF-1).\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003chr data-path-to-node=\"32\"\u003e\n\u003ch3 data-path-to-node=\"33\"\u003e\u003cb data-path-to-node=\"33\" data-index-in-node=\"0\"\u003eStorage \u0026amp; Handling\u003c\/b\u003e\u003c\/h3\u003e\n\u003cul data-path-to-node=\"34\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"34,0,0\"\u003e\u003cb data-path-to-node=\"34,0,0\" data-index-in-node=\"0\"\u003ePhysical State:\u003c\/b\u003e Lyophilized (Freeze-Dried) White Powder.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"34,1,0\"\u003e\u003cb data-path-to-node=\"34,1,0\" data-index-in-node=\"0\"\u003eStorage (Powder):\u003c\/b\u003e Store at -20°C (Freezer). Stable for up to 24 months.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"34,2,0\"\u003e\u003cb data-path-to-node=\"34,2,0\" data-index-in-node=\"0\"\u003eReconstitution:\u003c\/b\u003e\u003c\/p\u003e\n\u003cul data-path-to-node=\"34,2,1\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"34,2,1,0,0\"\u003e\u003cb data-path-to-node=\"34,2,1,0,0\" data-index-in-node=\"0\"\u003eSolvent:\u003c\/b\u003e Bacteriostatic Water or Sterile Saline.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"34,2,1,1,0\"\u003e\u003cb data-path-to-node=\"34,2,1,1,0\" data-index-in-node=\"0\"\u003eSolubility:\u003c\/b\u003e Highly soluble in water.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"34,3,0\"\u003e\u003cb data-path-to-node=\"34,3,0\" data-index-in-node=\"0\"\u003eStorage (Liquid):\u003c\/b\u003e Store at 4°C (Refrigerator). Use within 7 days. For herd-level stock solutions, aliquot and freeze to prevent degradation.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003chr data-path-to-node=\"35\"\u003e\n\u003ch3 data-path-to-node=\"36\"\u003e\u003cb data-path-to-node=\"36\" data-index-in-node=\"0\"\u003eDisclaimer\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp data-path-to-node=\"37\"\u003e\u003cb data-path-to-node=\"37\" data-index-in-node=\"0\"\u003eFOR RESEARCH USE ONLY.\u003c\/b\u003e This product is a chemical compound intended strictly for laboratory research and development. It is not approved by the FDA for clinical use, diagnostics, or therapeutic procedures in humans or animals. The physiological and toxicological properties of this chemical have not been fully investigated.\u003c\/p\u003e","brand":"Peptagon","offers":[{"title":"5mg","offer_id":47710109860054,"sku":"GONAD-5","price":29.0,"currency_code":"USD","in_stock":true},{"title":"10mg","offer_id":47710109892822,"sku":"GONAD-10","price":36.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0783\/3085\/5638\/files\/Gonadorelin-10mg.png?v=1768510871"},{"product_id":"kisspeptin-metastin-45-54-research-peptide","title":"Kisspeptin Research Peptide – 5mg \/ 10mg","description":"\u003ch4 data-path-to-node=\"13\"\u003e\u003cstrong\u003eKisspeptin Peptide (Lyophilized)\u003c\/strong\u003e\u003c\/h4\u003e\n\u003cp data-path-to-node=\"14\"\u003e\u003cb data-path-to-node=\"14\" data-index-in-node=\"0\"\u003eSequence:\u003c\/b\u003e YNWNSFGLRF-NH2 (Metastin residues 45-54) \u003cb data-path-to-node=\"14\" data-index-in-node=\"51\"\u003eFormat:\u003c\/b\u003e Sterile Lyophilized Powder (Vial) \u003cb data-path-to-node=\"14\" data-index-in-node=\"93\"\u003eReceptor:\u003c\/b\u003e KISS1R (GPR54) Agonist \u003cb data-path-to-node=\"14\" data-index-in-node=\"126\"\u003ePurity:\u003c\/b\u003e \u0026gt;98% (HPLC) \u003cb data-path-to-node=\"14\" data-index-in-node=\"146\"\u003eContent:\u003c\/b\u003e 10mg per vial\u003c\/p\u003e\n\u003chr data-path-to-node=\"15\"\u003e\n\u003ch3 data-path-to-node=\"16\"\u003e\u003cb data-path-to-node=\"16\" data-index-in-node=\"0\"\u003eProduct Overview\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp data-path-to-node=\"17\"\u003e\u003cb data-path-to-node=\"17\" data-index-in-node=\"0\"\u003eKisspeptin-10 (KP-10)\u003c\/b\u003e is the bioactive C-terminal decapeptide of the larger Kisspeptin-54 protein. It acts as the \"master switch\" of the Hypothalamic-Pituitary-Gonadal (HPG) axis.\u003c\/p\u003e\n\u003cp data-path-to-node=\"18\"\u003eResearch has established KP-10 as a potent secretagogue of \u003cb data-path-to-node=\"18\" data-index-in-node=\"59\"\u003eGonadotropin-Releasing Hormone (GnRH)\u003c\/b\u003e. By binding to the KISS1R receptor on GnRH neurons, it triggers the release of Luteinizing Hormone (LH) and Follicle-Stimulating Hormone (FSH), making it a critical tool for investigating fertility, testosterone production, and the neuroendocrine control of reproduction.\u003c\/p\u003e\n\u003chr data-path-to-node=\"19\"\u003e\n\u003ch3 data-path-to-node=\"20\"\u003e\u003cb data-path-to-node=\"20\" data-index-in-node=\"0\"\u003eMechanism of Action: The HPG Gatekeeper\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp data-path-to-node=\"21\"\u003eKisspeptin-10 functions via the Gq\/11-Phospholipase C pathway to depolarize GnRH neurons.\u003c\/p\u003e\n\u003cul data-path-to-node=\"22\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"22,0,0\"\u003e\u003cb data-path-to-node=\"22,0,0\" data-index-in-node=\"0\"\u003eGnRH Stimulation:\u003c\/b\u003e Binds to KISS1R on GnRH neurons in the hypothalamus, inhibiting potassium channels and activating TRPC channels. This causes rapid depolarization and pulsatile release of GnRH.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"22,1,0\"\u003e\u003cb data-path-to-node=\"22,1,0\" data-index-in-node=\"0\"\u003eMetabolic Integration:\u003c\/b\u003e Acts as a bridge between metabolism and reproduction. Its expression is regulated by \u003cb data-path-to-node=\"22,1,0\" data-index-in-node=\"108\"\u003eLeptin\u003c\/b\u003e, ensuring that reproductive function is coupled to energy availability.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"22,2,0\"\u003e\u003cb data-path-to-node=\"22,2,0\" data-index-in-node=\"0\"\u003eOncology (Metastasis):\u003c\/b\u003e Originally identified as \"Metastin,\" KP-10 suppresses metastasis in melanoma by inhibiting MMP-9 and inducing dormancy in disseminated tumor cells.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003chr data-path-to-node=\"23\"\u003e\n\u003ch3 data-path-to-node=\"24\"\u003e\u003cb data-path-to-node=\"24\" data-index-in-node=\"0\"\u003eKey Research Applications\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp data-path-to-node=\"25\"\u003e\u003cb data-path-to-node=\"25\" data-index-in-node=\"0\"\u003e1. Testosterone \u0026amp; Fertility\u003c\/b\u003e KP-10 is widely investigated for its ability to stimulate the release of LH and Testosterone in men without the testicular atrophy associated with exogenous TRT. It restores the HPG axis in conditions of hypogonadotropic hypogonadism.\u003c\/p\u003e\n\u003cp data-path-to-node=\"26\"\u003e\u003cb data-path-to-node=\"26\" data-index-in-node=\"0\"\u003e2. Metabolic Syndrome\u003c\/b\u003e Recent studies indicate that KP-10 can reverse the effects of a high-fat diet. In animal models, it reduced body weight, normalized blood glucose, and increased GLP-1 secretion, suggesting a role in treating obesity-related hypogonadism.\u003c\/p\u003e\n\u003cp data-path-to-node=\"27\"\u003e\u003cb data-path-to-node=\"27\" data-index-in-node=\"0\"\u003e3. Behavioral Neuroscience\u003c\/b\u003e Research using fMRI has shown that Kisspeptin administration enhances limbic brain activity in response to sexual and emotional stimuli, reducing sexual aversion and boosting social motivation and mood.\u003c\/p\u003e\n\u003chr data-path-to-node=\"28\"\u003e\n\u003ch3 data-path-to-node=\"29\"\u003e\u003cb data-path-to-node=\"29\" data-index-in-node=\"0\"\u003eStorage \u0026amp; Handling\u003c\/b\u003e\u003c\/h3\u003e\n\u003cul data-path-to-node=\"30\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"30,0,0\"\u003e\u003cb data-path-to-node=\"30,0,0\" data-index-in-node=\"0\"\u003ePhysical State:\u003c\/b\u003e Lyophilized (Freeze-Dried) White Powder.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"30,1,0\"\u003e\u003cb data-path-to-node=\"30,1,0\" data-index-in-node=\"0\"\u003eStorage (Powder):\u003c\/b\u003e Store at -20°C (Freezer). Stable for up to 36 months.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"30,2,0\"\u003e\u003cb data-path-to-node=\"30,2,0\" data-index-in-node=\"0\"\u003eReconstitution:\u003c\/b\u003e\u003c\/p\u003e\n\u003cul data-path-to-node=\"30,2,1\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"30,2,1,0,0\"\u003e\u003cb data-path-to-node=\"30,2,1,0,0\" data-index-in-node=\"0\"\u003eSolvent:\u003c\/b\u003e Sterile Water or Saline.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"30,2,1,1,0\"\u003e\u003cb data-path-to-node=\"30,2,1,1,0\" data-index-in-node=\"0\"\u003eSolubility:\u003c\/b\u003e Highly soluble.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"30,3,0\"\u003e\u003cb data-path-to-node=\"30,3,0\" data-index-in-node=\"0\"\u003eStorage (Liquid):\u003c\/b\u003e Store at 4°C (Refrigerator). \u003cb data-path-to-node=\"30,3,0\" data-index-in-node=\"47\"\u003eUse within 2-3 days.\u003c\/b\u003e KP-10 degrades rapidly in solution due to N-terminal cleavage; freeze single-use aliquots for longer storage.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003chr data-path-to-node=\"31\"\u003e\n\u003ch3 data-path-to-node=\"32\"\u003e\u003cb data-path-to-node=\"32\" data-index-in-node=\"0\"\u003eDisclaimer\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp data-path-to-node=\"33\"\u003e\u003cb data-path-to-node=\"33\" data-index-in-node=\"0\"\u003eFOR RESEARCH USE ONLY.\u003c\/b\u003e This product is a chemical compound intended strictly for laboratory research and development. It is not approved by the FDA for clinical use, diagnostics, or therapeutic procedures in humans or animals. The physiological and toxicological properties of this chemical have not been fully investigated.\u003c\/p\u003e","brand":"Peptagon","offers":[{"title":"5mg","offer_id":47712310460630,"sku":"KISSP-5","price":30.0,"currency_code":"USD","in_stock":true},{"title":"10mg","offer_id":47712310493398,"sku":"KISSP-10","price":38.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0783\/3085\/5638\/files\/Kisspeptin-5mg.png?v=1768510822"},{"product_id":"pnc-28-p53-derived-research-peptide","title":"PNC-28 Research Peptide – 20mg","description":"\u003ch4 data-path-to-node=\"13\"\u003e\u003cstrong\u003ePNC-28 Peptide (Lyophilized)\u003c\/strong\u003e\u003c\/h4\u003e\n\u003cp data-path-to-node=\"14\"\u003e\u003cb data-path-to-node=\"14\" data-index-in-node=\"0\"\u003eSequence:\u003c\/b\u003e ETFSDLWKLL-KKWKMRRNQFWVKVQRG (p53 17-26 + Penetratin) \u003cb data-path-to-node=\"14\" data-index-in-node=\"64\"\u003eFormat:\u003c\/b\u003e Sterile Lyophilized Powder (Vial) \u003cb data-path-to-node=\"14\" data-index-in-node=\"106\"\u003eMechanism:\u003c\/b\u003e MDM2-Mediated Membranolysis (Poptosis) \u003cb data-path-to-node=\"14\" data-index-in-node=\"156\"\u003ePurity:\u003c\/b\u003e \u0026gt;98% (HPLC) \u003cb data-path-to-node=\"14\" data-index-in-node=\"176\"\u003eContent:\u003c\/b\u003e 20mg per vial\u003c\/p\u003e\n\u003chr data-path-to-node=\"15\"\u003e\n\u003ch3 data-path-to-node=\"16\"\u003e\u003cb data-path-to-node=\"16\" data-index-in-node=\"0\"\u003eProduct Overview\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp data-path-to-node=\"17\"\u003e\u003cb data-path-to-node=\"17\" data-index-in-node=\"0\"\u003ePNC-28\u003c\/b\u003e is a synthetic fusion peptide derived from the p53 tumor suppressor protein. It consists of the p53 binding domain (residues 17-26) linked to a cell-penetrating \"penetratin\" sequence.\u003c\/p\u003e\n\u003cp data-path-to-node=\"18\"\u003eThis unique design allows PNC-28 to target malignant cells that overexpress MDM2 on their plasma membrane. Unlike traditional therapies that induce apoptosis, PNC-28 triggers a rapid form of necrosis known as \u003cb data-path-to-node=\"18\" data-index-in-node=\"209\"\u003e\"poptosis\"\u003c\/b\u003e (peptide-induced transmembrane pore formation), making it a critical tool for researching chemotherapy-resistant cell lines.\u003c\/p\u003e\n\u003chr data-path-to-node=\"19\"\u003e\n\u003ch3 data-path-to-node=\"20\"\u003e\u003cb data-path-to-node=\"20\" data-index-in-node=\"0\"\u003eMechanism of Action: The Necrotic Trigger\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp data-path-to-node=\"21\"\u003ePNC-28 operates via a biophysical mechanism distinct from standard p53 stabilizers.\u003c\/p\u003e\n\u003cul data-path-to-node=\"22\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"22,0,0\"\u003e\u003cb data-path-to-node=\"22,0,0\" data-index-in-node=\"0\"\u003eMDM2 Targeting:\u003c\/b\u003e The p53 segment binds to MDM2 proteins located on the surface of cancer cells (but absent on normal cells).\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"22,1,0\"\u003e\u003cb data-path-to-node=\"22,1,0\" data-index-in-node=\"0\"\u003ePore Formation:\u003c\/b\u003e Upon binding, the peptide undergoes a conformational change, assembling into oligomers that penetrate the cell membrane.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"22,2,0\"\u003e\u003cb data-path-to-node=\"22,2,0\" data-index-in-node=\"0\"\u003eRapid Lysis:\u003c\/b\u003e These oligomers form transmembrane pores (approx. 37 nm diameter), causing immediate leakage of intracellular contents and necrotic cell death, independent of intracellular p53 status.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003chr data-path-to-node=\"23\"\u003e\n\u003ch3 data-path-to-node=\"24\"\u003e\u003cb data-path-to-node=\"24\" data-index-in-node=\"0\"\u003eKey Research Applications\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp data-path-to-node=\"25\"\u003e\u003cb data-path-to-node=\"25\" data-index-in-node=\"0\"\u003e1. Malignant Cell Research\u003c\/b\u003e Investigated for its selective cytotoxicity against pancreatic (MiaPaCa-2), breast (MCF-7), and ovarian (SK-OV-3) cancer lines. Research shows it induces \u003cb data-path-to-node=\"25\" data-index-in-node=\"181\"\u003e100% cell death\u003c\/b\u003e in susceptible lines within 24-48 hours.\u003c\/p\u003e\n\u003cp data-path-to-node=\"26\"\u003e\u003cb data-path-to-node=\"26\" data-index-in-node=\"0\"\u003e2. Non-Apoptotic Pathways\u003c\/b\u003e Used to study cell death mechanisms that bypass traditional apoptosis resistance (e.g., Bcl-2 overexpression), offering a model for treating drug-resistant phenotypes.\u003c\/p\u003e\n\u003cp data-path-to-node=\"27\"\u003e\u003cb data-path-to-node=\"27\" data-index-in-node=\"0\"\u003e3. Stem Cell Selectivity\u003c\/b\u003e Studies indicate PNC-28 targets leukemia stem cells (LSCs) while sparing normal hematopoietic stem cells, making it a valuable probe for selective oncology research.\u003c\/p\u003e\n\u003chr data-path-to-node=\"28\"\u003e\n\u003ch3 data-path-to-node=\"29\"\u003e\u003cb data-path-to-node=\"29\" data-index-in-node=\"0\"\u003eStorage \u0026amp; Handling\u003c\/b\u003e\u003c\/h3\u003e\n\u003cul data-path-to-node=\"30\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"30,0,0\"\u003e\u003cb data-path-to-node=\"30,0,0\" data-index-in-node=\"0\"\u003ePhysical State:\u003c\/b\u003e Lyophilized (Freeze-Dried) White Powder.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"30,1,0\"\u003e\u003cb data-path-to-node=\"30,1,0\" data-index-in-node=\"0\"\u003eStorage (Powder):\u003c\/b\u003e Store at -20°C (Freezer). Stable for up to 24 months.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"30,2,0\"\u003e\u003cb data-path-to-node=\"30,2,0\" data-index-in-node=\"0\"\u003eReconstitution:\u003c\/b\u003e\u003c\/p\u003e\n\u003cul data-path-to-node=\"30,2,1\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"30,2,1,0,0\"\u003e\u003cb data-path-to-node=\"30,2,1,0,0\" data-index-in-node=\"0\"\u003eSolvent:\u003c\/b\u003e Sterile Water or 10-30% Acetic Acid (if solubility is low).\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"30,2,1,1,0\"\u003e\u003cb data-path-to-node=\"30,2,1,1,0\" data-index-in-node=\"0\"\u003eSonication:\u003c\/b\u003e May be required due to the peptide's amphipathic nature.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"30,3,0\"\u003e\u003cb data-path-to-node=\"30,3,0\" data-index-in-node=\"0\"\u003eStorage (Liquid):\u003c\/b\u003e Store at 4°C. Use within 14 days. \u003cb data-path-to-node=\"30,3,0\" data-index-in-node=\"52\"\u003eAvoid freeze-thaw cycles.\u003c\/b\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003chr data-path-to-node=\"31\"\u003e\n\u003ch3 data-path-to-node=\"32\"\u003e\u003cb data-path-to-node=\"32\" data-index-in-node=\"0\"\u003eDisclaimer\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp data-path-to-node=\"33\"\u003e\u003cb data-path-to-node=\"33\" data-index-in-node=\"0\"\u003eFOR RESEARCH USE ONLY.\u003c\/b\u003e This product is a chemical compound intended strictly for laboratory research and development. It is not approved by the FDA for clinical use, diagnostics, or therapeutic procedures in humans or animals. The physiological and toxicological properties of this chemical have not been fully investigated.\u003c\/p\u003e","brand":"Peptagon","offers":[{"title":"Default Title","offer_id":47712473153750,"sku":"PNC28-20","price":165.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0783\/3085\/5638\/files\/PNC-28-20mg.png?v=1768510757"}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0783\/3085\/5638\/collections\/Endocrine_Pathway_Research_Collection.png?v=1781104269","url":"https:\/\/peptagon.com\/collections\/endocrine-pathway-research.oembed","provider":"Peptagon","version":"1.0","type":"link"}