{"title":"Research Peptides","description":"\u003cp\u003ePeptagon’s Research Peptides collection includes peptide-based research materials organized for scientific and laboratory cataloging purposes. Peptides are short amino acid chains studied in laboratory models involving biological signaling, receptor pathway activity, cellular communication, protein interactions, and related biochemical processes.\u003c\/p\u003e\n\u003cp\u003eThis collection may include individual research peptides, lyophilized peptide materials, peptide solutions, and peptide-based formulations. Each product is intended strictly for qualified laboratory research use and is supported by transparent quality documentation where available.\u003c\/p\u003e\n\u003cp\u003eProducts in this collection are not dietary supplements, medications, cosmetics, or consumer health products, and are not for human or veterinary use.\u003c\/p\u003e","products":[{"product_id":"aod-9604-tyr-hgh-177-191-research-peptide","title":"AOD 9604 Research Peptide – 6mg","description":"\u003ch4 data-path-to-node=\"13\"\u003e\u003cstrong\u003eAOD 9604 Peptide (Lyophilized)\u003c\/strong\u003e\u003c\/h4\u003e\n\u003cp data-path-to-node=\"14\"\u003e\u003cb data-path-to-node=\"14\" data-index-in-node=\"0\"\u003eSequence:\u003c\/b\u003e Tyr-Leu-Arg-Ile-Val-Gln-Cys-Arg-Ser-Val-Glu-Gly-Ser-Cys-Gly-Phe \u003cb data-path-to-node=\"14\" data-index-in-node=\"74\"\u003eFormat:\u003c\/b\u003e Sterile Lyophilized Powder (Vial) \u003cb data-path-to-node=\"14\" data-index-in-node=\"116\"\u003eConfiguration:\u003c\/b\u003e Cyclic (Disulfide Bridge Cys7-Cys14) \u003cb data-path-to-node=\"14\" data-index-in-node=\"168\"\u003ePurity:\u003c\/b\u003e \u0026gt;99% (HPLC) \u003cb data-path-to-node=\"14\" data-index-in-node=\"188\"\u003eContent:\u003c\/b\u003e 6mg per vial\u003c\/p\u003e\n\u003chr data-path-to-node=\"15\"\u003e\n\u003ch3 data-path-to-node=\"16\"\u003e\u003cb data-path-to-node=\"16\" data-index-in-node=\"0\"\u003eProduct Overview\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp data-path-to-node=\"17\"\u003e\u003cb data-path-to-node=\"17\" data-index-in-node=\"0\"\u003eAOD 9604\u003c\/b\u003e (Advanced Obesity Drug) is a synthetic hexadecapeptide representing the C-terminal lipolytic domain of Human Growth Hormone (hGH residues 177-191).\u003c\/p\u003e\n\u003cp data-path-to-node=\"18\"\u003eOriginally developed to isolate the fat-burning properties of hGH from its insulin-antagonistic effects, this peptide features an N-terminal Tyrosine \"cap\" and a cyclic disulfide bridge. These modifications stabilize the molecular structure, allowing it to mimic the amphipathic alpha-helix of the native hormone. Research indicates it is a potent regulator of lipid metabolism and cartilage regeneration without stimulating IGF-1 or inducing hyperglycemia.\u003c\/p\u003e\n\u003chr data-path-to-node=\"19\"\u003e\n\u003ch3 data-path-to-node=\"20\"\u003e\u003cb data-path-to-node=\"20\" data-index-in-node=\"0\"\u003eMechanism of Action: The \"Push-Pull\" Effect\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp data-path-to-node=\"21\"\u003eAOD 9604 operates through a distinct non-hGHR pathway, exerting a specific influence on adipocytes and mesenchymal tissues.\u003c\/p\u003e\n\u003ch4 data-path-to-node=\"22\"\u003e\u003cb data-path-to-node=\"22\" data-index-in-node=\"0\"\u003e1. Metabolic Regulation (Fat Loss)\u003c\/b\u003e\u003c\/h4\u003e\n\u003cp data-path-to-node=\"23\"\u003eThe peptide utilizes a \"Push-Pull\" mechanism on adipose tissue:\u003c\/p\u003e\n\u003cul data-path-to-node=\"24\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"24,0,0\"\u003e\u003cb data-path-to-node=\"24,0,0\" data-index-in-node=\"0\"\u003eStimulation of Lipolysis (The Push):\u003c\/b\u003e It upregulates \u003cb data-path-to-node=\"24,0,0\" data-index-in-node=\"52\"\u003eBeta-3 Adrenergic Receptors (β3-AR)\u003c\/b\u003e on fat cells, enhancing the sensitivity to endogenous fat-burning signals.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"24,1,0\"\u003e\u003cb data-path-to-node=\"24,1,0\" data-index-in-node=\"0\"\u003eInhibition of Lipogenesis (The Pull):\u003c\/b\u003e It inhibits \u003cb data-path-to-node=\"24,1,0\" data-index-in-node=\"50\"\u003eLipoprotein Lipase (LPL)\u003c\/b\u003e and \u003cb data-path-to-node=\"24,1,0\" data-index-in-node=\"79\"\u003eAcetyl-CoA Carboxylase (ACC)\u003c\/b\u003e, preventing the uptake of dietary fat and the synthesis of new triglycerides.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch4 data-path-to-node=\"25\"\u003e\u003cb data-path-to-node=\"25\" data-index-in-node=\"0\"\u003e2. Musculoskeletal Regeneration\u003c\/b\u003e\u003c\/h4\u003e\n\u003cp data-path-to-node=\"26\"\u003eRecent investigations (Kwon et al.) have identified AOD 9604 as a chondroprotective agent.\u003c\/p\u003e\n\u003cul data-path-to-node=\"27\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"27,0,0\"\u003e\u003cb data-path-to-node=\"27,0,0\" data-index-in-node=\"0\"\u003eCartilage Repair:\u003c\/b\u003e In models of osteoarthritis, the peptide enhanced the synthesis of Collagen Type II and proteoglycans.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"27,1,0\"\u003e\u003cb data-path-to-node=\"27,1,0\" data-index-in-node=\"0\"\u003eSynergy with Hyaluronic Acid (HA):\u003c\/b\u003e When co-administered with HA, AOD 9604 demonstrated superior efficacy in reducing lameness and structural damage compared to either agent alone.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003chr data-path-to-node=\"28\"\u003e\n\u003ch3 data-path-to-node=\"29\"\u003e\u003cb data-path-to-node=\"29\" data-index-in-node=\"0\"\u003eChemical Specifications\u003c\/b\u003e\u003c\/h3\u003e\n\u003cul data-path-to-node=\"30\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"30,0,0\"\u003e\u003cb data-path-to-node=\"30,0,0\" data-index-in-node=\"0\"\u003eMolecular Formula:\u003c\/b\u003e C78H123N23O23S2\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"30,1,0\"\u003e\u003cb data-path-to-node=\"30,1,0\" data-index-in-node=\"0\"\u003eMolecular Mass:\u003c\/b\u003e 1815.1 Da\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"30,2,0\"\u003e\u003cb data-path-to-node=\"30,2,0\" data-index-in-node=\"0\"\u003eStructural Stability:\u003c\/b\u003e The disulfide bond between Cysteine 7 and Cysteine 14 creates a rigid cyclic loop essential for receptor recognition. The N-terminal Tyrosine protects against enzymatic degradation by aminopeptidases.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003chr data-path-to-node=\"31\"\u003e\n\u003ch3 data-path-to-node=\"32\"\u003e\u003cb data-path-to-node=\"32\" data-index-in-node=\"0\"\u003eSafety Profile \u0026amp; Selectivity\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp data-path-to-node=\"33\"\u003eAOD 9604 is distinguished by its high safety profile in research settings. Unlike full-length hGH, AOD 9604:\u003c\/p\u003e\n\u003cul data-path-to-node=\"34\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"34,0,0\"\u003e\u003cb data-path-to-node=\"34,0,0\" data-index-in-node=\"0\"\u003eDoes NOT release IGF-1:\u003c\/b\u003e Eliminating the risk of acromegaly or proliferative tissue growth.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"34,1,0\"\u003e\u003cb data-path-to-node=\"34,1,0\" data-index-in-node=\"0\"\u003eDoes NOT induce Insulin Resistance:\u003c\/b\u003e It has no effect on blood glucose or insulin sensitivity.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"34,2,0\"\u003e\u003cb data-path-to-node=\"34,2,0\" data-index-in-node=\"0\"\u003eHigh Tolerability:\u003c\/b\u003e In human trials involving over 900 subjects, no anti-peptide antibodies or significant adverse events were reported.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003chr data-path-to-node=\"35\"\u003e\n\u003ch3 data-path-to-node=\"36\"\u003e\u003cb data-path-to-node=\"36\" data-index-in-node=\"0\"\u003eStorage \u0026amp; Handling\u003c\/b\u003e\u003c\/h3\u003e\n\u003cul data-path-to-node=\"37\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"37,0,0\"\u003e\u003cb data-path-to-node=\"37,0,0\" data-index-in-node=\"0\"\u003ePhysical State:\u003c\/b\u003e Lyophilized (Freeze-Dried) White Powder.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"37,1,0\"\u003e\u003cb data-path-to-node=\"37,1,0\" data-index-in-node=\"0\"\u003eStorage (Lyophilized):\u003c\/b\u003e Store at -20°C (Freezer). Stable for up to 24 months.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"37,2,0\"\u003e\u003cb data-path-to-node=\"37,2,0\" data-index-in-node=\"0\"\u003eReconstitution:\u003c\/b\u003e Use Bacteriostatic Water (0.9% Benzyl Alcohol) or Sterile Saline. Inject diluent slowly to avoid foaming. \u003cb data-path-to-node=\"37,2,0\" data-index-in-node=\"122\"\u003eDo not shake.\u003c\/b\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"37,3,0\"\u003e\u003cb data-path-to-node=\"37,3,0\" data-index-in-node=\"0\"\u003eStorage (Reconstituted):\u003c\/b\u003e Store at 4°C (Refrigerator). Use within 14-21 days.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003chr data-path-to-node=\"38\"\u003e\n\u003ch3 data-path-to-node=\"39\"\u003e\u003cb data-path-to-node=\"39\" data-index-in-node=\"0\"\u003eDisclaimer\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp data-path-to-node=\"40\"\u003e\u003cb data-path-to-node=\"40\" data-index-in-node=\"0\"\u003eFOR RESEARCH USE ONLY.\u003c\/b\u003e This product is a chemical compound intended strictly for laboratory research and development. It is not approved by the FDA for clinical use, diagnostics, or therapeutic procedures in humans or animals. The physiological and toxicological properties of this chemical have not been fully investigated.\u003c\/p\u003e","brand":"Peptagon","offers":[{"title":"Default Title","offer_id":47709709369558,"sku":"AOD9604-6","price":42.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0783\/3085\/5638\/files\/AOD-9604-6mg.png?v=1768514591"},{"product_id":"ara-290-cibinetide-research-peptide","title":"ARA-290 Research Peptide – 14mg","description":"\u003ch4 data-path-to-node=\"13\"\u003e\u003cstrong\u003eARA-290 (Cibinetide) Peptide (Lyophilized)\u003c\/strong\u003e\u003c\/h4\u003e\n\u003cp data-path-to-node=\"14\"\u003e\u003cb data-path-to-node=\"14\" data-index-in-node=\"0\"\u003eSequence:\u003c\/b\u003e Glp-Glu-Gln-Leu-Glu-Arg-Ala-Leu-Asn-Ser-Ser \u003cb data-path-to-node=\"14\" data-index-in-node=\"54\"\u003eFormat:\u003c\/b\u003e Sterile Lyophilized Powder (Vial) \u003cb data-path-to-node=\"14\" data-index-in-node=\"96\"\u003eConfiguration:\u003c\/b\u003e Linear 11-mer (Pyroglutamate Modified) \u003cb data-path-to-node=\"14\" data-index-in-node=\"150\"\u003ePurity:\u003c\/b\u003e \u0026gt;99% (HPLC) \u003cb data-path-to-node=\"14\" data-index-in-node=\"170\"\u003eContent:\u003c\/b\u003e 14mg per vial\u003c\/p\u003e\n\u003chr data-path-to-node=\"15\"\u003e\n\u003ch3 data-path-to-node=\"16\"\u003e\u003cb data-path-to-node=\"16\" data-index-in-node=\"0\"\u003eProduct Overview\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp data-path-to-node=\"17\"\u003e\u003cb data-path-to-node=\"17\" data-index-in-node=\"0\"\u003eARA-290\u003c\/b\u003e, scientifically known as Cibinetide or Pyroglutamate Helix B Surface Peptide (pHBSP), is a synthetic 11-amino acid peptide engineered to harness the tissue-repair capabilities of Erythropoietin (EPO) without its blood-building side effects.\u003c\/p\u003e\n\u003cp data-path-to-node=\"18\"\u003eBy mimicking the 3D topography of EPO's Helix-B domain, ARA-290 acts as a highly selective agonist for the \u003cb data-path-to-node=\"18\" data-index-in-node=\"107\"\u003eInnate Repair Receptor (IRR)\u003c\/b\u003e. This receptor is transiently expressed only during tissue stress or injury. Consequently, ARA-290 activates potent anti-inflammatory and cytoprotective pathways selectively in damaged tissue, making it a primary subject of research for Small Fiber Neuropathy (SFN), Sarcoidosis, and metabolic dysregulation.\u003c\/p\u003e\n\u003chr data-path-to-node=\"19\"\u003e\n\u003ch3 data-path-to-node=\"20\"\u003e\u003cb data-path-to-node=\"20\" data-index-in-node=\"0\"\u003eMechanism of Action: Selective IRR Activation\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp data-path-to-node=\"21\"\u003eThe pharmacological value of ARA-290 lies in its receptor selectivity. It decouples the two primary functions of EPO:\u003c\/p\u003e\n\u003cul data-path-to-node=\"22\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"22,0,0\"\u003e\u003cb data-path-to-node=\"22,0,0\" data-index-in-node=\"0\"\u003eNo Hematopoietic Effect:\u003c\/b\u003e ARA-290 does \u003ci data-path-to-node=\"22,0,0\" data-index-in-node=\"38\"\u003enot\u003c\/i\u003e bind to the homodimeric EPO receptor (EPOR\/EPOR) responsible for red blood cell production. Therefore, it does not increase hematocrit or blood viscosity.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"22,1,0\"\u003e\u003cb data-path-to-node=\"22,1,0\" data-index-in-node=\"0\"\u003eTargeted Tissue Repair:\u003c\/b\u003e ARA-290 binds exclusively to the \u003cb data-path-to-node=\"22,1,0\" data-index-in-node=\"57\"\u003eInnate Repair Receptor (EPOR\/CD131)\u003c\/b\u003e. Activation of this complex triggers the downregulation of NF-κB (the master inflammatory switch) and the upregulation of SIRT1.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003chr data-path-to-node=\"23\"\u003e\n\u003ch3 data-path-to-node=\"24\"\u003e\u003cb data-path-to-node=\"24\" data-index-in-node=\"0\"\u003eKey Research Applications\u003c\/b\u003e\u003c\/h3\u003e\n\u003ch4 data-path-to-node=\"25\"\u003e\u003cb data-path-to-node=\"25\" data-index-in-node=\"0\"\u003e1. Small Fiber Neuropathy (SFN) \u0026amp; Neuroregeneration\u003c\/b\u003e\u003c\/h4\u003e\n\u003cp data-path-to-node=\"26\"\u003eARA-290 is unique in its ability to promote the structural regrowth of nerves.\u003c\/p\u003e\n\u003cul data-path-to-node=\"27\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"27,0,0\"\u003e\u003cb data-path-to-node=\"27,0,0\" data-index-in-node=\"0\"\u003eMechanism:\u003c\/b\u003e By suppressing perineural inflammation (TNF-α suppression) and shifting microglia to a reparative phenotype, it creates an environment permissive for axonal sprouting.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"27,1,0\"\u003e\u003cb data-path-to-node=\"27,1,0\" data-index-in-node=\"0\"\u003eClinical Evidence:\u003c\/b\u003e In Phase 2 trials involving Sarcoidosis patients, ARA-290 administration resulted in a significant increase in \u003cb data-path-to-node=\"27,1,0\" data-index-in-node=\"130\"\u003eCorneal Nerve Fiber Density (CNFD)\u003c\/b\u003e, providing objective anatomical proof of nerve regeneration.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch4 data-path-to-node=\"28\"\u003e\u003cb data-path-to-node=\"28\" data-index-in-node=\"0\"\u003e2. Chronic Inflammation \u0026amp; Autoimmunity\u003c\/b\u003e\u003c\/h4\u003e\n\u003cp data-path-to-node=\"29\"\u003eThe peptide targets the \u003cb data-path-to-node=\"29\" data-index-in-node=\"24\"\u003eSIRT1 \/ NF-κB Axis\u003c\/b\u003e.\u003c\/p\u003e\n\u003cul data-path-to-node=\"30\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"30,0,0\"\u003e\u003cb data-path-to-node=\"30,0,0\" data-index-in-node=\"0\"\u003eAction:\u003c\/b\u003e It reduces the acetylation of the NF-κB p65 subunit, effectively silencing the transcription of pro-inflammatory cytokines. This mechanism has been validated in models of autoimmune encephalomyelitis and apical periodontitis.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch4 data-path-to-node=\"31\"\u003e\u003cb data-path-to-node=\"31\" data-index-in-node=\"0\"\u003e3. Metabolic Syndrome (Type 2 Diabetes)\u003c\/b\u003e\u003c\/h4\u003e\n\u003cp data-path-to-node=\"32\"\u003eResearch in diabetic models indicates that ARA-290 may improve metabolic homeostasis. In human subjects with T2DM, treatment was associated with improved HbA1c levels and lipid profiles, suggesting that resolving systemic inflammation is a viable strategy for metabolic correction.\u003c\/p\u003e\n\u003chr data-path-to-node=\"33\"\u003e\n\u003ch3 data-path-to-node=\"34\"\u003e\u003cb data-path-to-node=\"34\" data-index-in-node=\"0\"\u003eChemical Specifications\u003c\/b\u003e\u003c\/h3\u003e\n\u003cul data-path-to-node=\"35\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"35,0,0\"\u003e\u003cb data-path-to-node=\"35,0,0\" data-index-in-node=\"0\"\u003eMolecular Formula:\u003c\/b\u003e C51H84N16O21\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"35,1,0\"\u003e\u003cb data-path-to-node=\"35,1,0\" data-index-in-node=\"0\"\u003eMolecular Mass:\u003c\/b\u003e 1257.3 Da\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"35,2,0\"\u003e\u003cb data-path-to-node=\"35,2,0\" data-index-in-node=\"0\"\u003eStructural Modifications:\u003c\/b\u003e The N-terminal residue is modified to \u003cb data-path-to-node=\"35,2,0\" data-index-in-node=\"64\"\u003ePyroglutamic Acid (Glp)\u003c\/b\u003e. This engineering choice confers significant resistance to aminopeptidase degradation, extending the peptide's plasma stability compared to native sequences.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003chr data-path-to-node=\"37\"\u003e\n\u003ch3 data-path-to-node=\"38\"\u003e\u003cb data-path-to-node=\"38\" data-index-in-node=\"0\"\u003eStorage \u0026amp; Handling\u003c\/b\u003e\u003c\/h3\u003e\n\u003cul data-path-to-node=\"39\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"39,0,0\"\u003e\u003cb data-path-to-node=\"39,0,0\" data-index-in-node=\"0\"\u003ePhysical State:\u003c\/b\u003e Lyophilized (Freeze-Dried) White Powder.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"39,1,0\"\u003e\u003cb data-path-to-node=\"39,1,0\" data-index-in-node=\"0\"\u003eStorage (Lyophilized):\u003c\/b\u003e Store at -20°C (Freezer). Stable for up to 24 months.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"39,2,0\"\u003e\u003cb data-path-to-node=\"39,2,0\" data-index-in-node=\"0\"\u003eReconstitution:\u003c\/b\u003e\u003c\/p\u003e\n\u003cul data-path-to-node=\"39,2,1\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"39,2,1,0,0\"\u003e\u003cb data-path-to-node=\"39,2,1,0,0\" data-index-in-node=\"0\"\u003eSolvent:\u003c\/b\u003e Sterile Water or Bacteriostatic Water.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"39,2,1,1,0\"\u003e\u003cb data-path-to-node=\"39,2,1,1,0\" data-index-in-node=\"0\"\u003eVolume Note:\u003c\/b\u003e This is a high-concentration \u003cb data-path-to-node=\"39,2,1,1,0\" data-index-in-node=\"42\"\u003e14mg\u003c\/b\u003e vial. To ensure complete dissolution, use at least \u003cb data-path-to-node=\"39,2,1,1,0\" data-index-in-node=\"98\"\u003e0.5mL - 1.0mL\u003c\/b\u003e of solvent. If using PBS, a larger volume (\u0026gt;5mL) may be required due to lower solubility in buffered salts.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"39,2,1,2,0\"\u003e\u003cb data-path-to-node=\"39,2,1,2,0\" data-index-in-node=\"0\"\u003epH:\u003c\/b\u003e If dissolution is slow, a slight adjustment to pH ~8.0 facilitates solubility.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"39,3,0\"\u003e\u003cb data-path-to-node=\"39,3,0\" data-index-in-node=\"0\"\u003eStorage (Reconstituted):\u003c\/b\u003e Store at 4°C (Refrigerator). Use within 7-14 days.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003chr data-path-to-node=\"40\"\u003e\n\u003ch3 data-path-to-node=\"41\"\u003e\u003cb data-path-to-node=\"41\" data-index-in-node=\"0\"\u003eDisclaimer\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp data-path-to-node=\"42\"\u003e\u003cb data-path-to-node=\"42\" data-index-in-node=\"0\"\u003eFOR RESEARCH USE ONLY.\u003c\/b\u003e This product is a chemical compound intended strictly for laboratory research and development. It is not approved by the FDA for clinical use, diagnostics, or therapeutic procedures in humans or animals. The physiological and toxicological properties of this chemical have not been fully investigated.\u003c\/p\u003e","brand":"Peptagon","offers":[{"title":"Default Title","offer_id":47709755965654,"sku":"ARA-14","price":69.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0783\/3085\/5638\/files\/ARA-290-14mg.png?v=1768505911"},{"product_id":"bdnf-recombinant-brain-derived-neurotrophic-factor","title":"BDNF Research Protein – 10mg","description":"\u003ch4 data-path-to-node=\"13\"\u003e\u003cstrong\u003eBDNF (Brain-Derived Neurotrophic Factor) Recombinant\u003c\/strong\u003e\u003c\/h4\u003e\n\u003cp data-path-to-node=\"14\"\u003e\u003cb data-path-to-node=\"14\" data-index-in-node=\"0\"\u003eSequence:\u003c\/b\u003e Homodimer (Non-covalent) | Mature 119 AA Subunits \u003cb data-path-to-node=\"14\" data-index-in-node=\"60\"\u003eFormat:\u003c\/b\u003e Sterile Lyophilized Powder (Vial) \u003cb data-path-to-node=\"14\" data-index-in-node=\"102\"\u003eSource:\u003c\/b\u003e Recombinant (E. coli) \u003cb data-path-to-node=\"14\" data-index-in-node=\"132\"\u003ePurity:\u003c\/b\u003e \u0026gt;98% (SDS-PAGE \u0026amp; HPLC) \u003cb data-path-to-node=\"14\" data-index-in-node=\"163\"\u003eContent:\u003c\/b\u003e 10mg per vial\u003c\/p\u003e\n\u003chr data-path-to-node=\"15\"\u003e\n\u003ch3 data-path-to-node=\"16\"\u003e\u003cb data-path-to-node=\"16\" data-index-in-node=\"0\"\u003eProduct Overview\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp data-path-to-node=\"17\"\u003e\u003cb data-path-to-node=\"17\" data-index-in-node=\"0\"\u003eBrain-Derived Neurotrophic Factor (BDNF)\u003c\/b\u003e is the most widely distributed and thoroughly researched neurotrophin in the mammalian central nervous system. This high-purity recombinant formulation (10mg) is scaled for chronic \u003ci data-path-to-node=\"17\" data-index-in-node=\"222\"\u003ein vivo\u003c\/i\u003e research, metabolic profiling, and systemic administration protocols.\u003c\/p\u003e\n\u003cp data-path-to-node=\"18\"\u003eBDNF acts as a \"pleiotropic modulator,\" orchestrating neuronal survival, differentiation, and synaptic plasticity. It functions via a precise \"Yin and Yang\" mechanism: the mature protein (mBDNF) drives neuroprotection and spinogenesis via the \u003cb data-path-to-node=\"18\" data-index-in-node=\"243\"\u003eTrkB Receptor\u003c\/b\u003e, while its precursor (proBDNF) regulates synaptic pruning via the \u003cb data-path-to-node=\"18\" data-index-in-node=\"323\"\u003ep75NTR\u003c\/b\u003e. This research-grade formulation is optimized to contain high-purity mature protein to ensure robust TrkB activation.\u003c\/p\u003e\n\u003chr data-path-to-node=\"19\"\u003e\n\u003ch3 data-path-to-node=\"20\"\u003e\u003cb data-path-to-node=\"20\" data-index-in-node=\"0\"\u003eMechanism of Action: The TrkB Signaling Axis\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp data-path-to-node=\"21\"\u003eUpon binding to the Tropomyosin receptor kinase B (TrkB), BDNF triggers three canonical signaling cascades essential for neuroplasticity:\u003c\/p\u003e\n\u003cul data-path-to-node=\"22\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"22,0,0\"\u003e\u003cb data-path-to-node=\"22,0,0\" data-index-in-node=\"0\"\u003eRas-MAPK\/ERK Pathway:\u003c\/b\u003e Drives the transcription of immediate-early genes like \u003ci data-path-to-node=\"22,0,0\" data-index-in-node=\"77\"\u003eArc\u003c\/i\u003e and \u003ci data-path-to-node=\"22,0,0\" data-index-in-node=\"85\"\u003ec-Fos\u003c\/i\u003e, which are indispensable for cytoskeletal reorganization.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"22,1,0\"\u003e\u003cb data-path-to-node=\"22,1,0\" data-index-in-node=\"0\"\u003ePI3K-Akt-mTOR Pathway:\u003c\/b\u003e Promotes cell survival by inhibiting apoptotic factors (BAD) and regulating protein translation for dendritic spine growth.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"22,2,0\"\u003e\u003cb data-path-to-node=\"22,2,0\" data-index-in-node=\"0\"\u003ePLC-γ Pathway:\u003c\/b\u003e Mobilizes intracellular Calcium to activate CaMKII, synergizing with MAPK to regulate synaptic strength.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003chr data-path-to-node=\"23\"\u003e\n\u003ch3 data-path-to-node=\"24\"\u003e\u003cb data-path-to-node=\"24\" data-index-in-node=\"0\"\u003eKey Research Applications\u003c\/b\u003e\u003c\/h3\u003e\n\u003ch4 data-path-to-node=\"25\"\u003e\u003cb data-path-to-node=\"25\" data-index-in-node=\"0\"\u003e1. Synaptic Plasticity \u0026amp; Memory (LTP)\u003c\/b\u003e\u003c\/h4\u003e\n\u003cp data-path-to-node=\"26\"\u003eBDNF is the critical mediator of Late-Phase Long-Term Potentiation (L-LTP).\u003c\/p\u003e\n\u003cul data-path-to-node=\"27\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"27,0,0\"\u003e\u003cb data-path-to-node=\"27,0,0\" data-index-in-node=\"0\"\u003eElectrophysiology:\u003c\/b\u003e Research in hippocampal slices demonstrates that BDNF infusion enhances the field excitatory postsynaptic potential (fEPSP) slope by over \u003cb data-path-to-node=\"27,0,0\" data-index-in-node=\"157\"\u003e60%\u003c\/b\u003e, significantly facilitating memory consolidation.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"27,1,0\"\u003e\u003cb data-path-to-node=\"27,1,0\" data-index-in-node=\"0\"\u003eDendritic Morphology:\u003c\/b\u003e Treatment shifts dendritic spines toward a mature \"mushroom\" phenotype, increasing spine density in the CA1 region.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch4 data-path-to-node=\"28\"\u003e\u003cb data-path-to-node=\"28\" data-index-in-node=\"0\"\u003e2. Neurodegenerative Rescue (Alzheimer's \u0026amp; Depression)\u003c\/b\u003e\u003c\/h4\u003e\n\u003cul data-path-to-node=\"29\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"29,0,0\"\u003e\u003cb data-path-to-node=\"29,0,0\" data-index-in-node=\"0\"\u003eAlzheimer's Models:\u003c\/b\u003e In transgenic amyloid models (J20), viral delivery of BDNF to the entorhinal cortex prevented spatial memory deficits, suggesting it confers \"synaptic resilience\" against amyloid toxicity.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"29,1,0\"\u003e\u003cb data-path-to-node=\"29,1,0\" data-index-in-node=\"0\"\u003eDepression:\u003c\/b\u003e In the Forced Swim Test (FST), intrahippocampal BDNF has been shown to restore mobility in corticosterone-exposed models, mimicking the efficacy of chronic antidepressant treatment.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch4 data-path-to-node=\"30\"\u003e\u003cb data-path-to-node=\"30\" data-index-in-node=\"0\"\u003e3. Systemic Physiology (Cardiac \u0026amp; Metabolic)\u003c\/b\u003e\u003c\/h4\u003e\n\u003cp data-path-to-node=\"31\"\u003eBDNF is a potent myokine and cardiokine.\u003c\/p\u003e\n\u003cul data-path-to-node=\"32\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"32,0,0\"\u003e\u003cb data-path-to-node=\"32,0,0\" data-index-in-node=\"0\"\u003eCardiac Repair:\u003c\/b\u003e In ischemia-reperfusion models, BDNF administration reduced total infarct volume by approximately \u003cb data-path-to-node=\"32,0,0\" data-index-in-node=\"114\"\u003e47%\u003c\/b\u003e by counter-regulating apoptotic ratios.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"32,1,0\"\u003e\u003cb data-path-to-node=\"32,1,0\" data-index-in-node=\"0\"\u003eMetabolic Regulation:\u003c\/b\u003e In diabetic (db\/db) mice, systemic BDNF enhanced glucose utilization in skeletal muscle via AMPK pathways, independent of insulin.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003chr data-path-to-node=\"33\"\u003e\n\u003ch3 data-path-to-node=\"34\"\u003e\u003cb data-path-to-node=\"34\" data-index-in-node=\"0\"\u003eChemical Specifications\u003c\/b\u003e\u003c\/h3\u003e\n\u003cul data-path-to-node=\"35\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"35,0,0\"\u003e\u003cb data-path-to-node=\"35,0,0\" data-index-in-node=\"0\"\u003eMolecular Weight:\u003c\/b\u003e ~27.0 kDa (Homodimer)\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"35,1,0\"\u003e\u003cb data-path-to-node=\"35,1,0\" data-index-in-node=\"0\"\u003eStructure:\u003c\/b\u003e Cystine-knot motif with three intrachain disulfide bonds per monomer.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"35,2,0\"\u003e\u003cb data-path-to-node=\"35,2,0\" data-index-in-node=\"0\"\u003eHomology:\u003c\/b\u003e Mature human BDNF shares absolute sequence identity with murine BDNF, making this recombinant human protein fully bioactive in mouse and rat models.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003chr data-path-to-node=\"37\"\u003e\n\u003ch3 data-path-to-node=\"38\"\u003e\u003cb data-path-to-node=\"38\" data-index-in-node=\"0\"\u003eStorage \u0026amp; Handling\u003c\/b\u003e\u003c\/h3\u003e\n\u003cul data-path-to-node=\"39\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"39,0,0\"\u003e\u003cb data-path-to-node=\"39,0,0\" data-index-in-node=\"0\"\u003ePhysical State:\u003c\/b\u003e Lyophilized (Freeze-Dried) Powder.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"39,1,0\"\u003e\u003cb data-path-to-node=\"39,1,0\" data-index-in-node=\"0\"\u003eStorage (Powder):\u003c\/b\u003e Store at -20°C to -80°C. Stable for up to 2 years.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"39,2,0\"\u003e\u003cb data-path-to-node=\"39,2,0\" data-index-in-node=\"0\"\u003eReconstitution:\u003c\/b\u003e\u003c\/p\u003e\n\u003cul data-path-to-node=\"39,2,1\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"39,2,1,0,0\"\u003e\u003cb data-path-to-node=\"39,2,1,0,0\" data-index-in-node=\"0\"\u003eConcentration:\u003c\/b\u003e Reconstitute to \u003cb data-path-to-node=\"39,2,1,0,0\" data-index-in-node=\"31\"\u003eno less than 100 µg\/mL\u003c\/b\u003e (0.1 mg\/mL) to prevent adsorption to vial walls.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"39,2,1,1,0\"\u003e\u003cb data-path-to-node=\"39,2,1,1,0\" data-index-in-node=\"0\"\u003eSolvent:\u003c\/b\u003e Sterile Water or 0.4% NaHCO3.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"39,3,0\"\u003e\u003cb data-path-to-node=\"39,3,0\" data-index-in-node=\"0\"\u003eStorage (Liquid):\u003c\/b\u003e Store at 4°C for up to 1 week. For long-term, aliquot and freeze at -20°C. \u003cb data-path-to-node=\"39,3,0\" data-index-in-node=\"93\"\u003eAvoid freeze-thaw cycles.\u003c\/b\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003chr data-path-to-node=\"40\"\u003e\n\u003ch3 data-path-to-node=\"41\"\u003e\u003cb data-path-to-node=\"41\" data-index-in-node=\"0\"\u003eDisclaimer\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp data-path-to-node=\"42\"\u003e\u003cb data-path-to-node=\"42\" data-index-in-node=\"0\"\u003eFOR RESEARCH USE ONLY.\u003c\/b\u003e This product is a chemical compound intended strictly for laboratory research and development. It is not approved by the FDA for clinical use, diagnostics, or therapeutic procedures in humans or animals. The physiological and toxicological properties of this chemical have not been fully investigated.\u003c\/p\u003e","brand":"Peptagon","offers":[{"title":"Default Title","offer_id":47709778706646,"sku":"BDNF-10","price":124.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0783\/3085\/5638\/files\/BDNF-10mgm.png?v=1768510121"},{"product_id":"bpc-157-acetate-lyophilized-research-peptide","title":"BPC-157 Acetate Research Peptide – 10mg","description":"\u003ch4 data-path-to-node=\"13\"\u003e\u003cstrong\u003eBPC-157 Acetate Peptide (Lyophilized)\u003c\/strong\u003e\u003c\/h4\u003e\n\u003cp data-path-to-node=\"14\"\u003e\u003cb data-path-to-node=\"14\" data-index-in-node=\"0\"\u003eSequence:\u003c\/b\u003e Gly-Glu-Pro-Pro-Pro-Gly-Lys-Pro-Ala-Asp-Asp-Ala-Gly-Leu-Val \u003cb data-path-to-node=\"14\" data-index-in-node=\"70\"\u003eFormat:\u003c\/b\u003e Sterile Lyophilized Powder (Vial) \u003cb data-path-to-node=\"14\" data-index-in-node=\"112\"\u003eSalt Form:\u003c\/b\u003e Acetate (Standard Research Grade) \u003cb data-path-to-node=\"14\" data-index-in-node=\"157\"\u003ePurity:\u003c\/b\u003e \u0026gt;99% (HPLC) \u003cb data-path-to-node=\"14\" data-index-in-node=\"177\"\u003eContent:\u003c\/b\u003e 10mg per vial\u003c\/p\u003e\n\u003chr data-path-to-node=\"15\"\u003e\n\u003ch3 data-path-to-node=\"16\"\u003e\u003cb data-path-to-node=\"16\" data-index-in-node=\"0\"\u003eProduct Overview\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp data-path-to-node=\"17\"\u003e\u003cb data-path-to-node=\"17\" data-index-in-node=\"0\"\u003eBPC-157 (Body Protection Compound-157)\u003c\/b\u003e is a stable pentadecapeptide derived from a partial sequence of a naturally occurring gastric protein. This \u003cb data-path-to-node=\"17\" data-index-in-node=\"147\"\u003e10mg Acetate\u003c\/b\u003e formulation is the standard reagent for parenteral (injectable) research applications.\u003c\/p\u003e\n\u003cp data-path-to-node=\"18\"\u003eKnown in the literature as a \"universal healing agent,\" BPC-157 acts as a pleiotropic modulator of the \u003cb data-path-to-node=\"18\" data-index-in-node=\"103\"\u003eNitric Oxide (NO) system\u003c\/b\u003e and the \u003cb data-path-to-node=\"18\" data-index-in-node=\"136\"\u003eVEGFR2-Akt-eNOS axis\u003c\/b\u003e. It is extensively investigated for its ability to accelerate the healing of mesenchymal tissues (tendons, ligaments, muscle) and recruit collateral blood flow in ischemic models.\u003c\/p\u003e\n\u003cp data-path-to-node=\"19\"\u003e\u003ci data-path-to-node=\"19\" data-index-in-node=\"0\"\u003eNote: This is the \u003cb data-path-to-node=\"19\" data-index-in-node=\"18\"\u003eAcetate\u003c\/b\u003e salt form, optimized for subcutaneous or intraperitoneal research. For oral stability research, the Arginate form is typically required.\u003c\/i\u003e\u003c\/p\u003e\n\u003chr data-path-to-node=\"20\"\u003e\n\u003ch3 data-path-to-node=\"21\"\u003e\u003cb data-path-to-node=\"21\" data-index-in-node=\"0\"\u003eMechanism of Action: The Homeostatic Modulator\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp data-path-to-node=\"22\"\u003eBPC-157 does not rely on a single receptor but rather modulates broad cellular signaling pathways to promote repair.\u003c\/p\u003e\n\u003ch4 data-path-to-node=\"23\"\u003e\u003cb data-path-to-node=\"23\" data-index-in-node=\"0\"\u003e1. Angiogenesis (Vascular Rescue)\u003c\/b\u003e\u003c\/h4\u003e\n\u003cp data-path-to-node=\"24\"\u003eBPC-157 activates the \u003cb data-path-to-node=\"24\" data-index-in-node=\"22\"\u003eVEGFR2-Akt-eNOS\u003c\/b\u003e pathway, driving the formation of new capillary networks.\u003c\/p\u003e\n\u003cul data-path-to-node=\"25\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"25,0,0\"\u003e\u003cb data-path-to-node=\"25,0,0\" data-index-in-node=\"0\"\u003e\"Bypassing Key\" Effect:\u003c\/b\u003e In models of ischemia, it recruits collateral vessels (like the azygos vein) to bypass obstructions and restore blood flow to damaged tissue.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"25,1,0\"\u003e\u003cb data-path-to-node=\"25,1,0\" data-index-in-node=\"0\"\u003eControlled Growth:\u003c\/b\u003e Unlike direct VEGF administration, BPC-157 promotes the formation of stable, non-leaky vasculature.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch4 data-path-to-node=\"26\"\u003e\u003cb data-path-to-node=\"26\" data-index-in-node=\"0\"\u003e2. Musculoskeletal Repair (FAK-Paxillin Axis)\u003c\/b\u003e\u003c\/h4\u003e\n\u003cp data-path-to-node=\"27\"\u003eIn tendon and muscle fibroblasts, the peptide activates \u003cb data-path-to-node=\"27\" data-index-in-node=\"56\"\u003eFocal Adhesion Kinase (FAK)\u003c\/b\u003e and \u003cb data-path-to-node=\"27\" data-index-in-node=\"88\"\u003ePaxillin\u003c\/b\u003e.\u003c\/p\u003e\n\u003cul data-path-to-node=\"28\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"28,0,0\"\u003e\u003cb data-path-to-node=\"28,0,0\" data-index-in-node=\"0\"\u003eCytoskeletal Organization:\u003c\/b\u003e Enhances the migration of fibroblasts to the site of injury.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"28,1,0\"\u003e\u003cb data-path-to-node=\"28,1,0\" data-index-in-node=\"0\"\u003eGHR Upregulation:\u003c\/b\u003e It specifically upregulates \u003cb data-path-to-node=\"28,1,0\" data-index-in-node=\"46\"\u003eGrowth Hormone Receptors (GHR)\u003c\/b\u003e in tendon tissue, increasing sensitivity to endogenous growth factors without the need for exogenous hormone administration.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch4 data-path-to-node=\"29\"\u003e\u003cb data-path-to-node=\"29\" data-index-in-node=\"0\"\u003e3. Nitric Oxide Modulation\u003c\/b\u003e\u003c\/h4\u003e\n\u003cp data-path-to-node=\"30\"\u003eBPC-157 acts as a stabilizer of the NO system. It can counteract the effects of both NO-blockade (L-NAME induced hypertension) and NO-overdose (L-Arginine induced hypotension), maintaining physiological homeostasis.\u003c\/p\u003e\n\u003chr data-path-to-node=\"31\"\u003e\n\u003ch3 data-path-to-node=\"32\"\u003e\u003cb data-path-to-node=\"32\" data-index-in-node=\"0\"\u003eKey Research Applications\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp data-path-to-node=\"33\"\u003e\u003cb data-path-to-node=\"33\" data-index-in-node=\"0\"\u003e1. Tendon \u0026amp; Ligament Healing\u003c\/b\u003e The \"Acetylated\" form is the gold standard for injection-based musculoskeletal research.\u003c\/p\u003e\n\u003cul data-path-to-node=\"34\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"34,0,0\"\u003e\u003cb data-path-to-node=\"34,0,0\" data-index-in-node=\"0\"\u003eAchilles Tendon Models:\u003c\/b\u003e Treatment significantly increases the \u003cb data-path-to-node=\"34,0,0\" data-index-in-node=\"62\"\u003e\"Load to Failure\"\u003c\/b\u003e (tensile strength) of healing tendons and restores the Young's modulus of elasticity.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"34,1,0\"\u003e\u003cb data-path-to-node=\"34,1,0\" data-index-in-node=\"0\"\u003eCorticosteroid Reversal:\u003c\/b\u003e Research indicates BPC-157 can neutralize the deleterious effects of systemic corticosteroids on tendon healing.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp data-path-to-node=\"35\"\u003e\u003cb data-path-to-node=\"35\" data-index-in-node=\"0\"\u003e2. Muscle Regeneration\u003c\/b\u003e In models of muscle crush or transection, BPC-157 mitigates atrophy and prevents scar tissue (fibrosis) formation, allowing for the complete restoration of functional motor patterns.\u003c\/p\u003e\n\u003cp data-path-to-node=\"36\"\u003e\u003cb data-path-to-node=\"36\" data-index-in-node=\"0\"\u003e3. Gastrointestinal Fistula Repair\u003c\/b\u003e Surgical research highlights the peptide's unique ability to heal complex fistulas (colovesical, rectovaginal). By promoting rapid vascularization and collagen deposition at the defect site, it achieves closure rates in animal models that far exceed standard care.\u003c\/p\u003e\n\u003cp data-path-to-node=\"37\"\u003e\u003cb data-path-to-node=\"37\" data-index-in-node=\"0\"\u003e4. Neuroprotection (Brain-Gut Axis)\u003c\/b\u003e BPC-157 demonstrates neuroprotective properties, reducing edema and neuronal death in Traumatic Brain Injury (TBI) models and antagonizing toxic encephalopathy caused by NSAID or serotonin overdose.\u003c\/p\u003e\n\u003chr data-path-to-node=\"38\"\u003e\n\u003ch3 data-path-to-node=\"39\"\u003e\u003cb data-path-to-node=\"39\" data-index-in-node=\"0\"\u003eStorage \u0026amp; Handling\u003c\/b\u003e\u003c\/h3\u003e\n\u003cul data-path-to-node=\"40\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"40,0,0\"\u003e\u003cb data-path-to-node=\"40,0,0\" data-index-in-node=\"0\"\u003ePhysical State:\u003c\/b\u003e Lyophilized (Freeze-Dried) White Powder.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"40,1,0\"\u003e\u003cb data-path-to-node=\"40,1,0\" data-index-in-node=\"0\"\u003eStorage (Lyophilized):\u003c\/b\u003e Store at -20°C (Freezer). Stable for \u0026gt;24 months.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"40,2,0\"\u003e\u003cb data-path-to-node=\"40,2,0\" data-index-in-node=\"0\"\u003eReconstitution:\u003c\/b\u003e\u003c\/p\u003e\n\u003cul data-path-to-node=\"40,2,1\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"40,2,1,0,0\"\u003e\u003cb data-path-to-node=\"40,2,1,0,0\" data-index-in-node=\"0\"\u003eSolvent:\u003c\/b\u003e Bacteriostatic Water or Sterile Saline.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"40,2,1,1,0\"\u003e\u003cb data-path-to-node=\"40,2,1,1,0\" data-index-in-node=\"0\"\u003eSolubility:\u003c\/b\u003e Freely soluble.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"40,3,0\"\u003e\u003cb data-path-to-node=\"40,3,0\" data-index-in-node=\"0\"\u003eStorage (Reconstituted):\u003c\/b\u003e Store at 4°C (Refrigerator). Use within 14 days. \u003cb data-path-to-node=\"40,3,0\" data-index-in-node=\"74\"\u003eAvoid freeze-thaw cycles.\u003c\/b\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003chr data-path-to-node=\"41\"\u003e\n\u003ch3 data-path-to-node=\"42\"\u003e\u003cb data-path-to-node=\"42\" data-index-in-node=\"0\"\u003eDisclaimer\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp data-path-to-node=\"43\"\u003e\u003cb data-path-to-node=\"43\" data-index-in-node=\"0\"\u003eFOR RESEARCH USE ONLY.\u003c\/b\u003e This product is a chemical compound intended strictly for laboratory research and development. It is not approved by the FDA for clinical use, diagnostics, or therapeutic procedures in humans or animals. The physiological and toxicological properties of this chemical have not been fully investigated.\u003c\/p\u003e","brand":"Peptagon","offers":[{"title":"Default Title","offer_id":47709778837718,"sku":"BPC157-AC-10","price":37.0,"currency_code":"USD","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0783\/3085\/5638\/files\/BPC-157-Acetate-Research-Peptide-10mg.png?v=1768835718"},{"product_id":"bpc-157-peptide-solution-research-vial","title":"BPC-157 Research Peptide Solution – 5mg \/ 10mg \/ 20mg","description":"\u003ch3 data-section-id=\"8w0o8b\" data-start=\"295\" data-end=\"357\"\u003e\u003cstrong data-start=\"299\" data-end=\"357\"\u003eHigh-Purity BPC-157 Solution for Research Applications\u003c\/strong\u003e\u003c\/h3\u003e\n\u003cp data-start=\"359\" data-end=\"548\"\u003eBPC-157 (Body Protection Compound-157) is a synthetic pentadecapeptide composed of 15 amino acids (GEPPPGKPADDAGLV), originally derived from a protein fragment found in human gastric juice.\u003c\/p\u003e\n\u003cp data-start=\"550\" data-end=\"736\"\u003eThis product is supplied as a \u003cstrong data-start=\"580\" data-end=\"613\"\u003epre-dissolved liquid solution\u003c\/strong\u003e, providing convenience and consistency for laboratory environments where precise handling and repeatability are essential.\u003c\/p\u003e\n\u003chr data-start=\"738\" data-end=\"741\"\u003e\n\u003ch3 data-section-id=\"pm8yra\" data-start=\"743\" data-end=\"763\"\u003e\u003cstrong data-start=\"747\" data-end=\"763\"\u003eKey Features\u003c\/strong\u003e\u003c\/h3\u003e\n\u003cul data-start=\"764\" data-end=\"992\"\u003e\n\u003cli data-section-id=\"521rk1\" data-start=\"764\" data-end=\"804\"\u003e\n\u003cp data-start=\"766\" data-end=\"804\"\u003e\u003cstrong data-start=\"766\" data-end=\"786\"\u003eAvailable Sizes:\u003c\/strong\u003e 5mg, 10mg, 20mg\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli data-section-id=\"173jx07\" data-start=\"805\" data-end=\"843\"\u003e\n\u003cp data-start=\"807\" data-end=\"843\"\u003e\u003cstrong data-start=\"807\" data-end=\"818\"\u003eFormat:\u003c\/strong\u003e Liquid solution (vial)\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli data-section-id=\"pffqqm\" data-start=\"844\" data-end=\"877\"\u003e\n\u003cp data-start=\"846\" data-end=\"877\"\u003e\u003cstrong data-start=\"846\" data-end=\"859\"\u003eSequence:\u003c\/strong\u003e GEPPPGKPADDAGLV\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli data-section-id=\"j2qt25\" data-start=\"878\" data-end=\"943\"\u003e\n\u003cp data-start=\"880\" data-end=\"943\"\u003e\u003cstrong data-start=\"880\" data-end=\"896\"\u003eHigh Purity:\u003c\/strong\u003e Manufactured for research-grade applications\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003chr data-start=\"994\" data-end=\"997\"\u003e\n\u003ch2 data-section-id=\"1engmd9\" data-start=\"999\" data-end=\"1024\"\u003e\u003cstrong data-start=\"1002\" data-end=\"1024\"\u003eMechanism Overview\u003c\/strong\u003e\u003c\/h2\u003e\n\u003cp data-start=\"1026\" data-end=\"1200\"\u003eBPC-157 has been investigated in preclinical research as a signaling modulator interacting with multiple biological pathways related to cellular response and tissue dynamics.\u003c\/p\u003e\n\u003chr data-start=\"1202\" data-end=\"1205\"\u003e\n\u003ch3 data-section-id=\"j6owv3\" data-start=\"1207\" data-end=\"1234\"\u003e\u003cstrong data-start=\"1211\" data-end=\"1234\"\u003eAngiogenic Pathways\u003c\/strong\u003e\u003c\/h3\u003e\n\u003cp data-start=\"1236\" data-end=\"1384\"\u003eResearch has explored BPC-157’s interaction with signaling pathways associated with vascular activity, including VEGFR2-Akt-eNOS-related mechanisms.\u003c\/p\u003e\n\u003cp data-start=\"1386\" data-end=\"1437\"\u003eThese pathways are commonly studied in relation to:\u003c\/p\u003e\n\u003cul data-start=\"1438\" data-end=\"1532\"\u003e\n\u003cli data-section-id=\"1ae56bw\" data-start=\"1438\" data-end=\"1469\"\u003e\n\u003cp data-start=\"1440\" data-end=\"1469\"\u003eCapillary network formation\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli data-section-id=\"4mwhpd\" data-start=\"1470\" data-end=\"1500\"\u003e\n\u003cp data-start=\"1472\" data-end=\"1500\"\u003eEndothelial cell signaling\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli data-section-id=\"1vexhh7\" data-start=\"1501\" data-end=\"1532\"\u003e\n\u003cp data-start=\"1503\" data-end=\"1532\"\u003eVascular response processes\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003chr data-start=\"1534\" data-end=\"1537\"\u003e\n\u003ch3 data-section-id=\"dlm7bw\" data-start=\"1539\" data-end=\"1587\"\u003e\u003cstrong data-start=\"1543\" data-end=\"1587\"\u003eCell Adhesion \u0026amp; Migration (FAK\/Paxillin)\u003c\/strong\u003e\u003c\/h3\u003e\n\u003cp data-start=\"1589\" data-end=\"1665\"\u003eIn experimental models, BPC-157 has been associated with pathways involving:\u003c\/p\u003e\n\u003cul data-start=\"1666\" data-end=\"1720\"\u003e\n\u003cli data-section-id=\"3x69uy\" data-start=\"1666\" data-end=\"1697\"\u003e\n\u003cp data-start=\"1668\" data-end=\"1697\"\u003eFocal Adhesion Kinase (FAK)\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli data-section-id=\"18v9q1d\" data-start=\"1698\" data-end=\"1720\"\u003e\n\u003cp data-start=\"1700\" data-end=\"1720\"\u003ePaxillin signaling\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp data-start=\"1722\" data-end=\"1753\"\u003eThese pathways are relevant to:\u003c\/p\u003e\n\u003cul data-start=\"1754\" data-end=\"1834\"\u003e\n\u003cli data-section-id=\"1pwfzfm\" data-start=\"1754\" data-end=\"1772\"\u003e\n\u003cp data-start=\"1756\" data-end=\"1772\"\u003eCell migration\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli data-section-id=\"1teml33\" data-start=\"1773\" data-end=\"1802\"\u003e\n\u003cp data-start=\"1775\" data-end=\"1802\"\u003eCytoskeletal organization\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli data-section-id=\"xaqj0q\" data-start=\"1803\" data-end=\"1834\"\u003e\n\u003cp data-start=\"1805\" data-end=\"1834\"\u003eCellular adhesion processes\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003chr data-start=\"1836\" data-end=\"1839\"\u003e\n\u003ch3 data-section-id=\"1nl1udp\" data-start=\"1841\" data-end=\"1880\"\u003e\u003cstrong data-start=\"1845\" data-end=\"1880\"\u003eNitric Oxide System Interaction\u003c\/strong\u003e\u003c\/h3\u003e\n\u003cp data-start=\"1882\" data-end=\"1994\"\u003eBPC-157 has also been studied for its interaction with nitric oxide (NO)-related pathways, which play a role in:\u003c\/p\u003e\n\u003cul data-start=\"1995\" data-end=\"2101\"\u003e\n\u003cli data-section-id=\"16vjo9m\" data-start=\"1995\" data-end=\"2017\"\u003e\n\u003cp data-start=\"1997\" data-end=\"2017\"\u003eCellular signaling\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli data-section-id=\"bbcxps\" data-start=\"2018\" data-end=\"2062\"\u003e\n\u003cp data-start=\"2020\" data-end=\"2062\"\u003eVascular function in experimental models\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli data-section-id=\"9wwbjq\" data-start=\"2063\" data-end=\"2101\"\u003e\n\u003cp data-start=\"2065\" data-end=\"2101\"\u003ePhysiological regulation processes\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003chr data-start=\"2103\" data-end=\"2106\"\u003e\n\u003ch2 data-section-id=\"4za2qr\" data-start=\"2108\" data-end=\"2131\"\u003e\u003cstrong data-start=\"2111\" data-end=\"2131\"\u003eResearch Context\u003c\/strong\u003e\u003c\/h2\u003e\n\u003cp data-start=\"2133\" data-end=\"2212\"\u003eBPC-157 continues to be a subject of interest in preclinical studies involving:\u003c\/p\u003e\n\u003cul data-start=\"2214\" data-end=\"2351\"\u003e\n\u003cli data-section-id=\"1l3wp6i\" data-start=\"2214\" data-end=\"2240\"\u003e\n\u003cp data-start=\"2216\" data-end=\"2240\"\u003eTissue response models\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli data-section-id=\"1rq3u23\" data-start=\"2241\" data-end=\"2272\"\u003e\n\u003cp data-start=\"2243\" data-end=\"2272\"\u003eCellular signaling pathways\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli data-section-id=\"k405p5\" data-start=\"2273\" data-end=\"2311\"\u003e\n\u003cp data-start=\"2275\" data-end=\"2311\"\u003eVascular and angiogenesis research\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli data-section-id=\"fhmey5\" data-start=\"2312\" data-end=\"2351\"\u003e\n\u003cp data-start=\"2314\" data-end=\"2351\"\u003eNitric oxide-related investigations\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003chr data-start=\"2353\" data-end=\"2356\"\u003e\n\u003ch2 data-section-id=\"1rzaed1\" data-start=\"2358\" data-end=\"2383\"\u003e\u003cstrong data-start=\"2361\" data-end=\"2383\"\u003eStorage \u0026amp; Handling\u003c\/strong\u003e\u003c\/h2\u003e\n\u003cul data-start=\"2385\" data-end=\"2568\"\u003e\n\u003cli data-section-id=\"1xcicio\" data-start=\"2385\" data-end=\"2426\"\u003e\n\u003cp data-start=\"2387\" data-end=\"2426\"\u003e\u003cstrong data-start=\"2387\" data-end=\"2402\"\u003eAppearance:\u003c\/strong\u003e Clear liquid solution\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli data-section-id=\"dt7no2\" data-start=\"2427\" data-end=\"2477\"\u003e\n\u003cp data-start=\"2429\" data-end=\"2477\"\u003e\u003cstrong data-start=\"2429\" data-end=\"2453\"\u003eRecommended Storage:\u003c\/strong\u003e 2–8°C (Refrigeration)\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli data-section-id=\"1oj2i35\" data-start=\"2478\" data-end=\"2517\"\u003e\n\u003cp data-start=\"2480\" data-end=\"2517\"\u003eAvoid contamination during handling\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli data-section-id=\"1sur3y9\" data-start=\"2518\" data-end=\"2568\"\u003e\n\u003cp data-start=\"2520\" data-end=\"2568\"\u003eDo not freeze unless specified by manufacturer\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003chr data-start=\"2570\" data-end=\"2573\"\u003e\n\u003ch2 data-section-id=\"1pt7sk9\" data-start=\"2575\" data-end=\"2598\"\u003e\u003cstrong data-start=\"2578\" data-end=\"2598\"\u003eImportant Notice\u003c\/strong\u003e\u003c\/h2\u003e\n\u003cp data-start=\"2600\" data-end=\"2625\"\u003e\u003cstrong data-start=\"2600\" data-end=\"2625\"\u003eFOR RESEARCH USE ONLY\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp data-start=\"2627\" data-end=\"2710\"\u003eThis product is intended strictly for laboratory research and development purposes.\u003c\/p\u003e\n\u003cul data-start=\"2712\" data-end=\"2854\"\u003e\n\u003cli data-section-id=\"4kaw9m\" data-start=\"2712\" data-end=\"2747\"\u003e\n\u003cp data-start=\"2714\" data-end=\"2747\"\u003eNot for human or veterinary use\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli data-section-id=\"1mfyl7l\" data-start=\"2748\" data-end=\"2798\"\u003e\n\u003cp data-start=\"2750\" data-end=\"2798\"\u003eNot for diagnostic or therapeutic applications\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli data-section-id=\"aro3jp\" data-start=\"2799\" data-end=\"2854\"\u003e\n\u003cp data-start=\"2801\" data-end=\"2854\"\u003eNot approved by the FDA or any regulatory authority\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e","brand":"Peptagon","offers":[{"title":"5mg","offer_id":47709780443350,"sku":"BPC157-5","price":30.0,"currency_code":"USD","in_stock":true},{"title":"10mg","offer_id":47709780476118,"sku":"BPC157-10","price":37.0,"currency_code":"USD","in_stock":true},{"title":"20mg","offer_id":47709780508886,"sku":"BPC157-20","price":94.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0783\/3085\/5638\/files\/BPC-157-5mg.png?v=1768507432"},{"product_id":"cardiogen-ala-glu-asp-arg-research-peptide","title":"Cardiogen Research Peptide – 25mg","description":"\u003ch4 data-path-to-node=\"13\"\u003e\u003cstrong\u003eCardiogen Peptide (Lyophilized)\u003c\/strong\u003e\u003c\/h4\u003e\n\u003cp data-path-to-node=\"14\"\u003e\u003cb data-path-to-node=\"14\" data-index-in-node=\"0\"\u003eSequence:\u003c\/b\u003e Ala-Glu-Asp-Arg (AEDR) \u003cb data-path-to-node=\"14\" data-index-in-node=\"33\"\u003eFormat:\u003c\/b\u003e Sterile Lyophilized Powder (Vial) \u003cb data-path-to-node=\"14\" data-index-in-node=\"75\"\u003eClass:\u003c\/b\u003e Synthetic Peptide Bioregulator (Cytogen) \u003cb data-path-to-node=\"14\" data-index-in-node=\"123\"\u003ePurity:\u003c\/b\u003e \u0026gt;98% (HPLC) \u003cb data-path-to-node=\"14\" data-index-in-node=\"143\"\u003eContent:\u003c\/b\u003e 20mg per vial\u003c\/p\u003e\n\u003chr data-path-to-node=\"15\"\u003e\n\u003ch3 data-path-to-node=\"16\"\u003e\u003cb data-path-to-node=\"16\" data-index-in-node=\"0\"\u003eProduct Overview\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp data-path-to-node=\"17\"\u003e\u003cb data-path-to-node=\"17\" data-index-in-node=\"0\"\u003eCardiogen\u003c\/b\u003e is a synthetic tetrapeptide (Ala-Glu-Asp-Arg) developed based on the amino acid analysis of cardiac tissue extracts. It belongs to the class of \"Cytogens\"—short-chain bioregulators designed to mimic endogenous signaling molecules that govern tissue repair and homeostasis.\u003c\/p\u003e\n\u003cp data-path-to-node=\"18\"\u003eUnlike standard cardiovascular pharmaceuticals that block receptors (e.g., Beta-blockers) or inhibit enzymes (e.g., ACE inhibitors), Cardiogen is posited to function as an \u003cb data-path-to-node=\"18\" data-index-in-node=\"172\"\u003eepigenetic modulator\u003c\/b\u003e. Research suggests it intervenes at the genomic level, initiating transcriptional programs that revitalize the protein synthetic machinery of cardiomyocytes and normalize extracellular matrix turnover. It is extensively studied for its potential in myocardial infarction recovery and the prevention of age-related cardiac decline.\u003c\/p\u003e\n\u003chr data-path-to-node=\"19\"\u003e\n\u003ch3 data-path-to-node=\"20\"\u003e\u003cb data-path-to-node=\"20\" data-index-in-node=\"0\"\u003eMechanism of Action: Epigenetic Regulation\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp data-path-to-node=\"21\"\u003eCardiogen functions according to the \"Peptide-DNA Interaction Theory.\" Its specific charge profile (Acidic Core\/Basic Terminus) allows it to enter the nucleus and bind directly to the major groove of DNA in GC-rich promoter regions.\u003c\/p\u003e\n\u003cul data-path-to-node=\"22\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"22,0,0\"\u003e\u003cb data-path-to-node=\"22,0,0\" data-index-in-node=\"0\"\u003eChromatin Decondensation:\u003c\/b\u003e Binding induces the \"unwinding\" (deheterochromatinization) of silenced chromatin, making genes accessible to transcription factors.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"22,1,0\"\u003e\u003cb data-path-to-node=\"22,1,0\" data-index-in-node=\"0\"\u003eTranscriptional Targets:\u003c\/b\u003e\u003c\/p\u003e\n\u003cul data-path-to-node=\"22,1,1\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"22,1,1,0,0\"\u003e\u003cb data-path-to-node=\"22,1,1,0,0\" data-index-in-node=\"0\"\u003eUpregulation:\u003c\/b\u003e Stimulates expression of proliferation markers (\u003cb data-path-to-node=\"22,1,1,0,0\" data-index-in-node=\"62\"\u003eKi-67\u003c\/b\u003e, \u003cb data-path-to-node=\"22,1,1,0,0\" data-index-in-node=\"69\"\u003ePCNA\u003c\/b\u003e) and differentiation factors (\u003cb data-path-to-node=\"22,1,1,0,0\" data-index-in-node=\"104\"\u003eNkx2.5\u003c\/b\u003e, \u003cb data-path-to-node=\"22,1,1,0,0\" data-index-in-node=\"112\"\u003eGATA4\u003c\/b\u003e) in cardiac tissue.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"22,1,1,1,0\"\u003e\u003cb data-path-to-node=\"22,1,1,1,0\" data-index-in-node=\"0\"\u003eDownregulation:\u003c\/b\u003e Uniquely downregulates \u003cb data-path-to-node=\"22,1,1,1,0\" data-index-in-node=\"39\"\u003ep53\u003c\/b\u003e (apoptosis checkpoint) in ischemic heart tissue, promoting cell survival during stress.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003chr data-path-to-node=\"23\"\u003e\n\u003ch3 data-path-to-node=\"24\"\u003e\u003cb data-path-to-node=\"24\" data-index-in-node=\"0\"\u003eKey Research Applications\u003c\/b\u003e\u003c\/h3\u003e\n\u003ch4 data-path-to-node=\"25\"\u003e\u003cb data-path-to-node=\"25\" data-index-in-node=\"0\"\u003e1. Myocardial Infarction \u0026amp; Ischemia\u003c\/b\u003e\u003c\/h4\u003e\n\u003cp data-path-to-node=\"26\"\u003eCardiogen is investigated for its ability to reduce infarct size and mortality in rodent models of coronary artery ligation.\u003c\/p\u003e\n\u003cul data-path-to-node=\"27\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"27,0,0\"\u003e\u003cb data-path-to-node=\"27,0,0\" data-index-in-node=\"0\"\u003eMetabolic Shielding:\u003c\/b\u003e It aids in the preservation of myocardial glycogen stores and mitochondrial integrity during hypoxia.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"27,1,0\"\u003e\u003cb data-path-to-node=\"27,1,0\" data-index-in-node=\"0\"\u003eTissue Salvage:\u003c\/b\u003e By suppressing p53-mediated apoptosis specifically in the heart, it preserves the \"penumbra\" (at-risk tissue) surrounding the necrotic core.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch4 data-path-to-node=\"28\"\u003e\u003cb data-path-to-node=\"28\" data-index-in-node=\"0\"\u003e2. Fibrosis \u0026amp; Remodeling\u003c\/b\u003e\u003c\/h4\u003e\n\u003cp data-path-to-node=\"29\"\u003eHeart failure is often driven by excessive scarring (fibrosis). Cardiogen acts to restore the equilibrium between cardiomyocytes and fibroblasts.\u003c\/p\u003e\n\u003cul data-path-to-node=\"30\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"30,0,0\"\u003e\u003cb data-path-to-node=\"30,0,0\" data-index-in-node=\"0\"\u003eFibroblast Modulation:\u003c\/b\u003e It discourages the \"myofibroblast\" phenotype, reducing excessive collagen deposition.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"30,1,0\"\u003e\u003cb data-path-to-node=\"30,1,0\" data-index-in-node=\"0\"\u003eMatrix Integrity:\u003c\/b\u003e Promotes the synthesis of physiological structural proteins (Actin, Vimentin, Lamin A\/C) rather than scar tissue, helping to maintain ventricular geometry and prevent dilation.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch4 data-path-to-node=\"31\"\u003e\u003cb data-path-to-node=\"31\" data-index-in-node=\"0\"\u003e3. Oncological Safety (The p53 Paradox)\u003c\/b\u003e\u003c\/h4\u003e\n\u003cp data-path-to-node=\"32\"\u003eA critical distinction in Cardiogen research is its context-dependent action. While it suppresses p53 in healthy heart tissue to prevent cell death, studies (Levdik \u0026amp; Knyazkin) indicate it \u003cb data-path-to-node=\"32\" data-index-in-node=\"189\"\u003einhibits\u003c\/b\u003e tumor growth (e.g., M-1 Sarcoma) by inducing hemorrhagic necrosis in tumor vasculature. This suggests a true \"bioregulatory\" function—supporting homeostasis while disrupting pathology.\u003c\/p\u003e\n\u003chr data-path-to-node=\"33\"\u003e\n\u003ch3 data-path-to-node=\"34\"\u003e\u003cb data-path-to-node=\"34\" data-index-in-node=\"0\"\u003eImportant Distinction: Cardiogen vs. Cardiogenol C\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp data-path-to-node=\"35\"\u003eResearchers must distinguish between two similarly named but chemically distinct compounds:\u003c\/p\u003e\n\u003cul data-path-to-node=\"36\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"36,0,0\"\u003e\u003cb data-path-to-node=\"36,0,0\" data-index-in-node=\"0\"\u003eCardiogen (This Product):\u003c\/b\u003e A synthetic \u003cb data-path-to-node=\"36,0,0\" data-index-in-node=\"38\"\u003etetrapeptide (Ala-Glu-Asp-Arg)\u003c\/b\u003e used for in vivo bioregulation and tissue repair.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"36,1,0\"\u003e\u003cb data-path-to-node=\"36,1,0\" data-index-in-node=\"0\"\u003eCardiogenol C:\u003c\/b\u003e A synthetic \u003cb data-path-to-node=\"36,1,0\" data-index-in-node=\"27\"\u003esmall molecule (Diaminopyrimidine)\u003c\/b\u003e used primarily in vitro to force stem cell differentiation.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"36,2,0\"\u003e\u003ci data-path-to-node=\"36,2,0\" data-index-in-node=\"0\"\u003eThis listing is for the Tetrapeptide (AEDR).\u003c\/i\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003chr data-path-to-node=\"37\"\u003e\n\u003ch3 data-path-to-node=\"38\"\u003e\u003cb data-path-to-node=\"38\" data-index-in-node=\"0\"\u003eStorage \u0026amp; Handling\u003c\/b\u003e\u003c\/h3\u003e\n\u003cul data-path-to-node=\"39\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"39,0,0\"\u003e\u003cb data-path-to-node=\"39,0,0\" data-index-in-node=\"0\"\u003ePhysical State:\u003c\/b\u003e Lyophilized (Freeze-Dried) Powder.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"39,1,0\"\u003e\u003cb data-path-to-node=\"39,1,0\" data-index-in-node=\"0\"\u003eStorage (Powder):\u003c\/b\u003e Store at -20°C (Freezer). Stable for up to 24 months.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"39,2,0\"\u003e\u003cb data-path-to-node=\"39,2,0\" data-index-in-node=\"0\"\u003eReconstitution:\u003c\/b\u003e\u003c\/p\u003e\n\u003cul data-path-to-node=\"39,2,1\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"39,2,1,0,0\"\u003e\u003cb data-path-to-node=\"39,2,1,0,0\" data-index-in-node=\"0\"\u003eSolvent:\u003c\/b\u003e Bacteriostatic Water or Sterile Saline.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"39,2,1,1,0\"\u003e\u003cb data-path-to-node=\"39,2,1,1,0\" data-index-in-node=\"0\"\u003eSolubility:\u003c\/b\u003e Hydrophilic and readily soluble.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"39,3,0\"\u003e\u003cb data-path-to-node=\"39,3,0\" data-index-in-node=\"0\"\u003eStorage (Liquid):\u003c\/b\u003e Store at 4°C (Refrigerator). Use within 14 days to prevent degradation.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003chr data-path-to-node=\"40\"\u003e\n\u003ch3 data-path-to-node=\"41\"\u003e\u003cb data-path-to-node=\"41\" data-index-in-node=\"0\"\u003eDisclaimer\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp data-path-to-node=\"42\"\u003e\u003cb data-path-to-node=\"42\" data-index-in-node=\"0\"\u003eFOR RESEARCH USE ONLY.\u003c\/b\u003e This product is a chemical compound intended strictly for laboratory research and development. It is not approved by the FDA for clinical use, diagnostics, or therapeutic procedures in humans or animals. The physiological and toxicological properties of this chemical have not been fully investigated.\u003c\/p\u003e","brand":"Peptagon","offers":[{"title":"Default Title","offer_id":47709951918294,"sku":"CARDIO-25","price":36.0,"currency_code":"USD","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0783\/3085\/5638\/files\/Cardiogen-20MG.png?v=1768510161"},{"product_id":"cartalax-ala-glu-asp-research-peptide","title":"Cartalax Research Peptide – 25mg","description":"\u003ch4 data-path-to-node=\"13\"\u003e\u003cstrong\u003eCartalax Peptide (Lyophilized)\u003c\/strong\u003e\u003c\/h4\u003e\n\u003cp data-path-to-node=\"14\"\u003e\u003cb data-path-to-node=\"14\" data-index-in-node=\"0\"\u003eSequence:\u003c\/b\u003e Ala-Glu-Asp (AED) \u003cb data-path-to-node=\"14\" data-index-in-node=\"28\"\u003eFormat:\u003c\/b\u003e Sterile Lyophilized Powder (Vial) \u003cb data-path-to-node=\"14\" data-index-in-node=\"70\"\u003eClass:\u003c\/b\u003e Synthetic Peptide Bioregulator (Cytogen AC-4) \u003cb data-path-to-node=\"14\" data-index-in-node=\"123\"\u003ePurity:\u003c\/b\u003e \u0026gt;98% (HPLC) \u003cb data-path-to-node=\"14\" data-index-in-node=\"143\"\u003eContent:\u003c\/b\u003e 25mg per vial\u003c\/p\u003e\n\u003chr data-path-to-node=\"15\"\u003e\n\u003ch3 data-path-to-node=\"16\"\u003e\u003cb data-path-to-node=\"16\" data-index-in-node=\"0\"\u003eProduct Overview\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp data-path-to-node=\"17\"\u003e\u003cb data-path-to-node=\"17\" data-index-in-node=\"0\"\u003eCartalax\u003c\/b\u003e (also designated as \u003cb data-path-to-node=\"17\" data-index-in-node=\"29\"\u003eT-31\u003c\/b\u003e or \u003cb data-path-to-node=\"17\" data-index-in-node=\"37\"\u003eAC-4\u003c\/b\u003e) is a synthetic tripeptide (L-Alanyl-L-Glutamyl-L-Aspartic acid) designed to mimic specific peptide fragments found in young, healthy cartilage. It belongs to the \"Khavinson Peptide\" family of bioregulators.\u003c\/p\u003e\n\u003cp data-path-to-node=\"18\"\u003eUnlike traditional growth factors that act on cell surface receptors, Cartalax functions as an \u003cb data-path-to-node=\"18\" data-index-in-node=\"95\"\u003eepigenetic switch\u003c\/b\u003e. It is engineered to penetrate the nuclei of chondrocytes and fibroblasts, interacting directly with chromatin to reactivate the gene expression programs associated with tissue repair. It is the primary subject of research for reversing connective tissue senescence, treating osteoarthritis, and functionalizing scaffolds for tissue engineering.\u003c\/p\u003e\n\u003cp data-path-to-node=\"19\"\u003e\u003ci data-path-to-node=\"19\" data-index-in-node=\"0\"\u003eNote: Do not confuse AC-4 (Cartalax\/Cartilage) with AC-2 (Vesugen\/Vascular).\u003c\/i\u003e\u003c\/p\u003e\n\u003chr data-path-to-node=\"20\"\u003e\n\u003ch3 data-path-to-node=\"21\"\u003e\u003cb data-path-to-node=\"21\" data-index-in-node=\"0\"\u003eMechanism of Action: Epigenetic Remodeling\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp data-path-to-node=\"22\"\u003eCartalax operates via the \"Sequence-Specific DNA Binding Model.\" Its nanoscale size allow it to pass through nuclear pores and bind to the major groove of DNA.\u003c\/p\u003e\n\u003cul data-path-to-node=\"23\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"23,0,0\"\u003e\u003cb data-path-to-node=\"23,0,0\" data-index-in-node=\"0\"\u003eChromatin Relaxation:\u003c\/b\u003e The peptide reduces the electrostatic attraction between histones and DNA. This converts silenced Heterochromatin into active Euchromatin, allowing repair genes to be transcribed.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"23,1,0\"\u003e\u003cb data-path-to-node=\"23,1,0\" data-index-in-node=\"0\"\u003eTarget Gene Activation:\u003c\/b\u003e\u003c\/p\u003e\n\u003cul data-path-to-node=\"23,1,1\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"23,1,1,0,0\"\u003e\u003cb data-path-to-node=\"23,1,1,0,0\" data-index-in-node=\"0\"\u003eCOL11A1 Upregulation:\u003c\/b\u003e It specifically acts as a \"matrikine,\" mimicking Type XI collagen breakdown to signal the synthesis of new Type XI collagen (critical for nucleating Type II fibrils).\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"23,1,1,1,0\"\u003e\u003cb data-path-to-node=\"23,1,1,1,0\" data-index-in-node=\"0\"\u003eProliferation:\u003c\/b\u003e Significantly increases \u003cb data-path-to-node=\"23,1,1,1,0\" data-index-in-node=\"39\"\u003eKi-67\u003c\/b\u003e expression, signaling senescent cells to re-enter the cell cycle.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"23,1,1,2,0\"\u003e\u003cb data-path-to-node=\"23,1,1,2,0\" data-index-in-node=\"0\"\u003eAnti-Apoptotic:\u003c\/b\u003e Downregulates \u003cb data-path-to-node=\"23,1,1,2,0\" data-index-in-node=\"30\"\u003ep53\u003c\/b\u003e and \u003cb data-path-to-node=\"23,1,1,2,0\" data-index-in-node=\"38\"\u003eCaspase-3\u003c\/b\u003e, preventing cell death in aging tissues.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003chr data-path-to-node=\"24\"\u003e\n\u003ch3 data-path-to-node=\"25\"\u003e\u003cb data-path-to-node=\"25\" data-index-in-node=\"0\"\u003eKey Research Applications\u003c\/b\u003e\u003c\/h3\u003e\n\u003ch4 data-path-to-node=\"26\"\u003e\u003cb data-path-to-node=\"26\" data-index-in-node=\"0\"\u003e1. Osteoarthritis \u0026amp; Cartilage Repair\u003c\/b\u003e\u003c\/h4\u003e\n\u003cp data-path-to-node=\"27\"\u003eIn organotypic tissue cultures (explants), Cartalax has been shown to increase the \"Area Index\" (migration and growth of cells) by \u003cb data-path-to-node=\"27\" data-index-in-node=\"131\"\u003e30-40%\u003c\/b\u003e.\u003c\/p\u003e\n\u003cul data-path-to-node=\"28\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"28,0,0\"\u003e\u003cb data-path-to-node=\"28,0,0\" data-index-in-node=\"0\"\u003eSenescence Reversal:\u003c\/b\u003e It targets the \"senescence-associated secretory phenotype\" (SASP), shifting chondrocytes from a catabolic state to an anabolic state.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"28,1,0\"\u003e\u003cb data-path-to-node=\"28,1,0\" data-index-in-node=\"0\"\u003eMatrix Architecture:\u003c\/b\u003e By promoting Type XI collagen, it ensures the proper structural organization of the cartilage matrix, distinct from generic collagen boosters.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch4 data-path-to-node=\"29\"\u003e\u003cb data-path-to-node=\"29\" data-index-in-node=\"0\"\u003e2. Osteoporosis \u0026amp; Bone Density\u003c\/b\u003e\u003c\/h4\u003e\n\u003cp data-path-to-node=\"30\"\u003eResearch in ovariectomized rat models indicates that Cartalax mitigates the loss of Bone Mineral Density (BMD). The Ala-Glu-Asp sequence appears to influence osteoblasts via mechanisms similar to those in chondrocytes, supporting mineralization.\u003c\/p\u003e\n\u003ch4 data-path-to-node=\"31\"\u003e\u003cb data-path-to-node=\"31\" data-index-in-node=\"0\"\u003e3. Tissue Engineering (Scaffolds)\u003c\/b\u003e\u003c\/h4\u003e\n\u003cp data-path-to-node=\"32\"\u003eCartalax is utilized in bio-material research to functionalize hydrogels. By chemically tethering the peptide to scaffolds (e.g., chitosan or PEG), researchers can create \"bioactive\" implants that drive stem cell differentiation toward the chondrogenic lineage.\u003c\/p\u003e\n\u003chr data-path-to-node=\"33\"\u003e\n\u003ch3 data-path-to-node=\"34\"\u003e\u003cb data-path-to-node=\"34\" data-index-in-node=\"0\"\u003eStorage \u0026amp; Handling\u003c\/b\u003e\u003c\/h3\u003e\n\u003cul data-path-to-node=\"35\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"35,0,0\"\u003e\u003cb data-path-to-node=\"35,0,0\" data-index-in-node=\"0\"\u003ePhysical State:\u003c\/b\u003e Lyophilized (Freeze-Dried) Powder.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"35,1,0\"\u003e\u003cb data-path-to-node=\"35,1,0\" data-index-in-node=\"0\"\u003eStorage (Powder):\u003c\/b\u003e Store at -20°C (Freezer). Stable for up to 24 months.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"35,2,0\"\u003e\u003cb data-path-to-node=\"35,2,0\" data-index-in-node=\"0\"\u003eReconstitution:\u003c\/b\u003e\u003c\/p\u003e\n\u003cul data-path-to-node=\"35,2,1\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"35,2,1,0,0\"\u003e\u003cb data-path-to-node=\"35,2,1,0,0\" data-index-in-node=\"0\"\u003eSolvent:\u003c\/b\u003e Bacteriostatic Water or Sterile PBS.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"35,2,1,1,0\"\u003e\u003cb data-path-to-node=\"35,2,1,1,0\" data-index-in-node=\"0\"\u003eSolubility:\u003c\/b\u003e Highly soluble due to acidic residues.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"35,3,0\"\u003e\u003cb data-path-to-node=\"35,3,0\" data-index-in-node=\"0\"\u003eStorage (Liquid):\u003c\/b\u003e Store at 4°C (Refrigerator). Use within 14 days or aliquot and freeze to avoid degradation.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003chr data-path-to-node=\"36\"\u003e\n\u003ch3 data-path-to-node=\"37\"\u003e\u003cb data-path-to-node=\"37\" data-index-in-node=\"0\"\u003eDisclaimer\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp data-path-to-node=\"38\"\u003e\u003cb data-path-to-node=\"38\" data-index-in-node=\"0\"\u003eFOR RESEARCH USE ONLY.\u003c\/b\u003e This product is a chemical compound intended strictly for laboratory research and development. It is not approved by the FDA for clinical use, diagnostics, or therapeutic procedures in humans or animals. The physiological and toxicological properties of this chemical have not been fully investigated.\u003c\/p\u003e","brand":"Peptagon","offers":[{"title":"Default Title","offer_id":47709952147670,"sku":"CARTA-25","price":41.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0783\/3085\/5638\/files\/Cartalax-25mg.png?v=1768507488"},{"product_id":"cjc-1295-no-dac-modified-grf-1-29-research-peptide","title":"CJC-1295 No DAC Research Peptide – 10mg","description":"\u003ch4 data-path-to-node=\"13\"\u003e\u003cstrong\u003eCJC-1295 No DAC (Modified GRF 1-29) Peptide\u003c\/strong\u003e\u003c\/h4\u003e\n\u003cp data-path-to-node=\"14\"\u003e\u003cb data-path-to-node=\"14\" data-index-in-node=\"0\"\u003eSequence:\u003c\/b\u003e Tyr-D-Ala-Asp-Ala-Ile-Phe-Thr-Gln-Ser-Tyr-Arg-Lys-Val-Leu-Ala-Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Leu-Ser-Arg-NH2 \u003cb data-path-to-node=\"14\" data-index-in-node=\"132\"\u003eFormat:\u003c\/b\u003e Sterile Lyophilized Powder (Vial) \u003cb data-path-to-node=\"14\" data-index-in-node=\"174\"\u003eClass:\u003c\/b\u003e Tetrasubstituted GHRH Analogue \u003cb data-path-to-node=\"14\" data-index-in-node=\"212\"\u003eHalf-Life:\u003c\/b\u003e ~30 Minutes (Pulsatile) \u003cb data-path-to-node=\"14\" data-index-in-node=\"247\"\u003ePurity:\u003c\/b\u003e \u0026gt;99% (HPLC) \u003cb data-path-to-node=\"14\" data-index-in-node=\"267\"\u003eContent:\u003c\/b\u003e Available in 5mg and 10mg vials\u003c\/p\u003e\n\u003chr data-path-to-node=\"15\"\u003e\n\u003ch3 data-path-to-node=\"16\"\u003e\u003cb data-path-to-node=\"16\" data-index-in-node=\"0\"\u003eProduct Overview\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp data-path-to-node=\"17\"\u003e\u003cb data-path-to-node=\"17\" data-index-in-node=\"0\"\u003eCJC-1295 No DAC\u003c\/b\u003e, scientifically known as \u003cb data-path-to-node=\"17\" data-index-in-node=\"41\"\u003eModified GRF 1-29\u003c\/b\u003e, is a rational engineering triumph in neuroendocrinology. It is a synthetic, tetrasubstituted analogue of the native Growth Hormone-Releasing Hormone (GHRH) 1-29 fragment.\u003c\/p\u003e\n\u003cp data-path-to-node=\"18\"\u003eUnlike native GHRH, which is degraded within minutes, Modified GRF 1-29 incorporates four specific amino acid substitutions that render it resistant to enzymatic cleavage (DPP-IV) and chemical oxidation. This extends its biological half-life to approximately \u003cb data-path-to-node=\"18\" data-index-in-node=\"259\"\u003e30 minutes\u003c\/b\u003e. Crucially, because it lacks the Drug Affinity Complex (DAC), it preserves the \u003cb data-path-to-node=\"18\" data-index-in-node=\"349\"\u003enatural, pulsatile secretion\u003c\/b\u003e of Growth Hormone, avoiding the \"GH bleed\" and receptor desensitization associated with continuous long-acting analogs.\u003c\/p\u003e\n\u003chr data-path-to-node=\"19\"\u003e\n\u003ch3 data-path-to-node=\"20\"\u003e\u003cb data-path-to-node=\"20\" data-index-in-node=\"0\"\u003eMechanism of Action: The Pulsatile Signal\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp data-path-to-node=\"21\"\u003eModified GRF 1-29 acts as a selective agonist for the GHRH Receptor (GHRH-R) on pituitary somatotrophs.\u003c\/p\u003e\n\u003cul data-path-to-node=\"22\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"22,0,0\"\u003e\u003cb data-path-to-node=\"22,0,0\" data-index-in-node=\"0\"\u003ecAMP-PKA Pathway:\u003c\/b\u003e Binding triggers the Gs-protein cascade, increasing intracellular cAMP. This initiates both immediate vesicle release (secretion) and long-term gene transcription (synthesis via Pit-1).\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"22,1,0\"\u003e\u003cb data-path-to-node=\"22,1,0\" data-index-in-node=\"0\"\u003eDPP-IV Resistance:\u003c\/b\u003e The substitution of \u003cb data-path-to-node=\"22,1,0\" data-index-in-node=\"39\"\u003eD-Alanine\u003c\/b\u003e at position 2 prevents the enzyme DPP-IV from cleaving the peptide, ensuring sustained receptor activation compared to native Sermorelin.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"22,2,0\"\u003e\u003cb data-path-to-node=\"22,2,0\" data-index-in-node=\"0\"\u003eSynergy:\u003c\/b\u003e It effectively \"loads the gun\" (synthesis), making it highly synergistic with Ghrelin mimetics (GHRPs) that \"pull the trigger\" (release).\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003chr data-path-to-node=\"23\"\u003e\n\u003ch3 data-path-to-node=\"24\"\u003e\u003cb data-path-to-node=\"24\" data-index-in-node=\"0\"\u003eChemical Engineering: The 4 Modifications\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp data-path-to-node=\"25\"\u003eThe \"Modified\" designation refers to four specific changes to the native sequence that optimize stability for research use:\u003c\/p\u003e\n\u003col start=\"1\" data-path-to-node=\"26\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"26,0,0\"\u003e\u003cb data-path-to-node=\"26,0,0\" data-index-in-node=\"0\"\u003eTyr1-D-Ala2:\u003c\/b\u003e Confers resistance to DPP-IV digestion.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"26,1,0\"\u003e\u003cb data-path-to-node=\"26,1,0\" data-index-in-node=\"0\"\u003eGln8:\u003c\/b\u003e Replaces Asparagine to prevent deamidation and improve shelf-stability.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"26,2,0\"\u003e\u003cb data-path-to-node=\"26,2,0\" data-index-in-node=\"0\"\u003eAla15:\u003c\/b\u003e Replaces Glycine to stabilize the alpha-helical structure for better receptor binding.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"26,3,0\"\u003e\u003cb data-path-to-node=\"26,3,0\" data-index-in-node=\"0\"\u003eLeu27:\u003c\/b\u003e Replaces Methionine to prevent oxidation (sulfoxide formation) during storage.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ol\u003e\n\u003chr data-path-to-node=\"27\"\u003e\n\u003ch3 data-path-to-node=\"28\"\u003e\u003cb data-path-to-node=\"28\" data-index-in-node=\"0\"\u003eKey Research Applications\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp data-path-to-node=\"29\"\u003e\u003cb data-path-to-node=\"29\" data-index-in-node=\"0\"\u003e1. Pulsatile GH Secretion\u003c\/b\u003e Research confirms that Modified GRF 1-29 amplifies the natural peaks of GH secretion without elevating the basal \"trough\" levels. This mimics youthful physiology and allows for receptor resensitization between pulses.\u003c\/p\u003e\n\u003cp data-path-to-node=\"30\"\u003e\u003cb data-path-to-node=\"30\" data-index-in-node=\"0\"\u003e2. Sleep Architecture (SWS)\u003c\/b\u003e GHRH is a potent somnogenic factor. Studies utilizing EEG monitoring indicate that administration prior to the sleep window enhances \u003cb data-path-to-node=\"30\" data-index-in-node=\"161\"\u003eSlow Wave Sleep (SWS)\u003c\/b\u003e and Delta wave power, which correlates with improved cognitive recovery and endogenous hormonal repair.\u003c\/p\u003e\n\u003cp data-path-to-node=\"31\"\u003e\u003cb data-path-to-node=\"31\" data-index-in-node=\"0\"\u003e3. Lipolysis (Fat Loss)\u003c\/b\u003e Through the pulsatile elevation of GH, Modified GRF 1-29 activates \u003cb data-path-to-node=\"31\" data-index-in-node=\"91\"\u003eHormone Sensitive Lipase (HSL)\u003c\/b\u003e in adipocytes. Research shows a preference for visceral adipose tissue reduction, mediated by the downregulation of PPAR-gamma.\u003c\/p\u003e\n\u003chr data-path-to-node=\"32\"\u003e\n\u003ch3 data-path-to-node=\"33\"\u003e\u003cb data-path-to-node=\"33\" data-index-in-node=\"0\"\u003eStorage \u0026amp; Handling\u003c\/b\u003e\u003c\/h3\u003e\n\u003cul data-path-to-node=\"34\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"34,0,0\"\u003e\u003cb data-path-to-node=\"34,0,0\" data-index-in-node=\"0\"\u003ePhysical State:\u003c\/b\u003e Lyophilized (Freeze-Dried) White Powder.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"34,1,0\"\u003e\u003cb data-path-to-node=\"34,1,0\" data-index-in-node=\"0\"\u003eStorage (Lyophilized):\u003c\/b\u003e Store at -20°C (Freezer). Stable for \u0026gt;24 months.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"34,2,0\"\u003e\u003cb data-path-to-node=\"34,2,0\" data-index-in-node=\"0\"\u003eReconstitution:\u003c\/b\u003e\u003c\/p\u003e\n\u003cul data-path-to-node=\"34,2,1\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"34,2,1,0,0\"\u003e\u003cb data-path-to-node=\"34,2,1,0,0\" data-index-in-node=\"0\"\u003eSolvent:\u003c\/b\u003e Bacteriostatic Water or Sterile Saline.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"34,2,1,1,0\"\u003e\u003cb data-path-to-node=\"34,2,1,1,0\" data-index-in-node=\"0\"\u003eSolubility:\u003c\/b\u003e Highly soluble (polar\/basic profile).\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"34,3,0\"\u003e\u003cb data-path-to-node=\"34,3,0\" data-index-in-node=\"0\"\u003eStorage (Reconstituted):\u003c\/b\u003e Store at 4°C (Refrigerator). Use within 14-21 days. The Leu27 substitution significantly improves solution stability compared to native GHRH.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003chr data-path-to-node=\"35\"\u003e\n\u003ch3 data-path-to-node=\"36\"\u003e\u003cb data-path-to-node=\"36\" data-index-in-node=\"0\"\u003eDisclaimer\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp data-path-to-node=\"37\"\u003e\u003cb data-path-to-node=\"37\" data-index-in-node=\"0\"\u003eFOR RESEARCH USE ONLY.\u003c\/b\u003e This product is a chemical compound intended strictly for laboratory research and development. It is not approved by the FDA for clinical use, diagnostics, or therapeutic procedures in humans or animals. The physiological and toxicological properties of this chemical have not been fully investigated.\u003c\/p\u003e","brand":"Peptagon","offers":[{"title":"10mg","offer_id":47709956112598,"sku":"CJC-NODAC-10","price":43.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0783\/3085\/5638\/files\/CJC-1295-No-DAC-10mg.png?v=1768509497"},{"product_id":"cjc-1295-with-dac-ghrh-research-peptide","title":"CJC-1295 with DAC Research Peptide – 10mg","description":"\u003ch4 data-path-to-node=\"13\"\u003e\u003cstrong\u003eCJC-1295 with DAC Peptide (Lyophilized)\u003c\/strong\u003e\u003c\/h4\u003e\n\u003cp data-path-to-node=\"14\"\u003e\u003cb data-path-to-node=\"14\" data-index-in-node=\"0\"\u003eSequence:\u003c\/b\u003e Tyr-D-Ala-Asp-Ala-Ile-Phe-Thr-Gln-Ser-Tyr-Arg-Lys-Val-Leu-Ala-Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Leu-Ser-Arg-Lys(Maleimidopropionic acid)-NH2 \u003cb data-path-to-node=\"14\" data-index-in-node=\"161\"\u003eFormat:\u003c\/b\u003e Sterile Lyophilized Powder (Vial) \u003cb data-path-to-node=\"14\" data-index-in-node=\"203\"\u003eConjugation:\u003c\/b\u003e Drug Affinity Complex (DAC) \u003cb data-path-to-node=\"14\" data-index-in-node=\"244\"\u003eHalf-Life:\u003c\/b\u003e 6 to 8 Days (Long-Acting) \u003cb data-path-to-node=\"14\" data-index-in-node=\"281\"\u003ePurity:\u003c\/b\u003e \u0026gt;99% (HPLC) \u003cb data-path-to-node=\"14\" data-index-in-node=\"301\"\u003eContent:\u003c\/b\u003e Available in 5mg and 10mg vials\u003c\/p\u003e\n\u003chr data-path-to-node=\"15\"\u003e\n\u003ch3 data-path-to-node=\"16\"\u003e\u003cb data-path-to-node=\"16\" data-index-in-node=\"0\"\u003eProduct Overview\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp data-path-to-node=\"17\"\u003e\u003cb data-path-to-node=\"17\" data-index-in-node=\"0\"\u003eCJC-1295 with DAC\u003c\/b\u003e is a long-acting, tetrasubstituted analogue of Growth Hormone-Releasing Hormone (GHRH). It is distinguished by its unique \u003cb data-path-to-node=\"17\" data-index-in-node=\"140\"\u003eDrug Affinity Complex (DAC)\u003c\/b\u003e technology, which conjugates the peptide to serum albumin in vivo.\u003c\/p\u003e\n\u003cp data-path-to-node=\"18\"\u003eThis conjugation extends the biological half-life from minutes to \u003cb data-path-to-node=\"18\" data-index-in-node=\"66\"\u003e6–8 days\u003c\/b\u003e, creating a sustained elevation of Growth Hormone (GH) and IGF-1. This contrasts with \"Modified GRF 1-29\" (No DAC), which produces short, pulsatile spikes. This formulation is the primary subject of research for protocols requiring once-weekly administration and steady-state hormone elevation.\u003c\/p\u003e\n\u003chr data-path-to-node=\"19\"\u003e\n\u003ch3 data-path-to-node=\"20\"\u003e\u003cb data-path-to-node=\"20\" data-index-in-node=\"0\"\u003eMechanism of Action: In Vivo Bioconjugation\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp data-path-to-node=\"21\"\u003eCJC-1295 utilizes a sophisticated \"Trojan Horse\" delivery system via the DAC moiety.\u003c\/p\u003e\n\u003cul data-path-to-node=\"22\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"22,0,0\"\u003e\u003cb data-path-to-node=\"22,0,0\" data-index-in-node=\"0\"\u003eMaleimide Linker:\u003c\/b\u003e The peptide contains a maleimide group at the C-terminus that reacts specifically with \u003cb data-path-to-node=\"22,0,0\" data-index-in-node=\"105\"\u003eCysteine-34\u003c\/b\u003e on circulating serum albumin.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"22,1,0\"\u003e\u003cb data-path-to-node=\"22,1,0\" data-index-in-node=\"0\"\u003eAlbumin Shielding:\u003c\/b\u003e Once bound to albumin (67 kDa), the peptide is shielded from enzymatic degradation (DPP-IV) and is too large to be filtered by the kidneys.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"22,2,0\"\u003e\u003cb data-path-to-node=\"22,2,0\" data-index-in-node=\"0\"\u003eSustained Release:\u003c\/b\u003e The albumin conjugate circulates for weeks, providing continuous stimulation to the pituitary GHRH receptors.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003chr data-path-to-node=\"23\"\u003e\n\u003ch3 data-path-to-node=\"24\"\u003e\u003cb data-path-to-node=\"24\" data-index-in-node=\"0\"\u003eKey Research Applications\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp data-path-to-node=\"25\"\u003e\u003cb data-path-to-node=\"25\" data-index-in-node=\"0\"\u003e1. Sustained GH \u0026amp; IGF-1 Elevation\u003c\/b\u003e Clinical research (Teichman et al.) demonstrated that a single injection increases mean GH levels by \u003cb data-path-to-node=\"25\" data-index-in-node=\"135\"\u003e2- to 10-fold\u003c\/b\u003e and sustains elevated IGF-1 for up to \u003cb data-path-to-node=\"25\" data-index-in-node=\"187\"\u003e28 days\u003c\/b\u003e. This makes it ideal for research into chronic anabolism and lipolysis where daily injections are not feasible.\u003c\/p\u003e\n\u003cp data-path-to-node=\"26\"\u003e\u003cb data-path-to-node=\"26\" data-index-in-node=\"0\"\u003e2. GHRH Knockout Rescue\u003c\/b\u003e In GHRH knockout models, once-weekly administration of CJC-1295 was sufficient to normalize growth and induce pituitary hyperplasia (growth of somatotroph cells), proving its potent trophic effects.\u003c\/p\u003e\n\u003cp data-path-to-node=\"27\"\u003e\u003cb data-path-to-node=\"27\" data-index-in-node=\"0\"\u003e3. Lipodystrophy \u0026amp; Metabolic Research\u003c\/b\u003e Investigated for its ability to redistribute visceral fat and improve metabolic profiles in lipodystrophy models. The continuous GH pressure drives profound lipolysis via Hormone Sensitive Lipase (HSL).\u003c\/p\u003e\n\u003chr data-path-to-node=\"28\"\u003e\n\u003ch3 data-path-to-node=\"29\"\u003e\u003cb data-path-to-node=\"29\" data-index-in-node=\"0\"\u003eImportant Distinction: DAC vs. No DAC\u003c\/b\u003e\u003c\/h3\u003e\n\u003cul data-path-to-node=\"30\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"30,0,0\"\u003e\u003cb data-path-to-node=\"30,0,0\" data-index-in-node=\"0\"\u003eCJC-1295 with DAC:\u003c\/b\u003e Half-life of \u003cb data-path-to-node=\"30,0,0\" data-index-in-node=\"32\"\u003e6-8 days\u003c\/b\u003e. Causes a \"bleed\" or continuous wave of GH. Dosed weekly.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"30,1,0\"\u003e\u003cb data-path-to-node=\"30,1,0\" data-index-in-node=\"0\"\u003eModified GRF 1-29 (No DAC):\u003c\/b\u003e Half-life of \u003cb data-path-to-node=\"30,1,0\" data-index-in-node=\"41\"\u003e30 minutes\u003c\/b\u003e. Causes distinct pulses. Dosed 3x daily.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"30,2,0\"\u003e\u003ci data-path-to-node=\"30,2,0\" data-index-in-node=\"0\"\u003eThis listing is for the DAC (Long-Acting) variant.\u003c\/i\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003chr data-path-to-node=\"31\"\u003e\n\u003ch3 data-path-to-node=\"32\"\u003e\u003cb data-path-to-node=\"32\" data-index-in-node=\"0\"\u003eStorage \u0026amp; Handling\u003c\/b\u003e\u003c\/h3\u003e\n\u003cul data-path-to-node=\"33\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"33,0,0\"\u003e\u003cb data-path-to-node=\"33,0,0\" data-index-in-node=\"0\"\u003ePhysical State:\u003c\/b\u003e Lyophilized (Freeze-Dried) White Powder.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"33,1,0\"\u003e\u003cb data-path-to-node=\"33,1,0\" data-index-in-node=\"0\"\u003eStorage (Lyophilized):\u003c\/b\u003e Store at -20°C (Freezer). Stable for \u0026gt;24 months.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"33,2,0\"\u003e\u003cb data-path-to-node=\"33,2,0\" data-index-in-node=\"0\"\u003eReconstitution:\u003c\/b\u003e\u003c\/p\u003e\n\u003cul data-path-to-node=\"33,2,1\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"33,2,1,0,0\"\u003e\u003cb data-path-to-node=\"33,2,1,0,0\" data-index-in-node=\"0\"\u003eSolvent:\u003c\/b\u003e Bacteriostatic Water or Sterile Saline.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"33,2,1,1,0\"\u003e\u003cb data-path-to-node=\"33,2,1,1,0\" data-index-in-node=\"0\"\u003eSolubility:\u003c\/b\u003e Highly soluble.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"33,3,0\"\u003e\u003cb data-path-to-node=\"33,3,0\" data-index-in-node=\"0\"\u003eStorage (Reconstituted):\u003c\/b\u003e Store at 4°C (Refrigerator). While more stable than native GHRH, use within 14-21 days to ensure the maleimide linker remains active for conjugation.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003chr data-path-to-node=\"34\"\u003e\n\u003ch3 data-path-to-node=\"35\"\u003e\u003cb data-path-to-node=\"35\" data-index-in-node=\"0\"\u003eDisclaimer\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp data-path-to-node=\"36\"\u003e\u003cb data-path-to-node=\"36\" data-index-in-node=\"0\"\u003eFOR RESEARCH USE ONLY.\u003c\/b\u003e This product is a chemical compound intended strictly for laboratory research and development. It is not approved by the FDA for clinical use, diagnostics, or therapeutic procedures in humans or animals. The physiological and toxicological properties of this chemical have not been fully investigated.\u003c\/p\u003e","brand":"Peptagon","offers":[{"title":"Default Title","offer_id":47710005002454,"sku":"CJC-DAC-10","price":63.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0783\/3085\/5638\/files\/CJC-1295-With-DAC-10mg.png?v=1768509489"},{"product_id":"curcumin-natural-polyphenol-research-reagent","title":"Curcumin Research Reagent – 600mg","description":"\u003ch4 data-path-to-node=\"13\"\u003e\u003cstrong\u003eCurcumin Research Reagent (Crystalline)\u003c\/strong\u003e\u003c\/h4\u003e\n\u003cp data-path-to-node=\"14\"\u003e\u003cb data-index-in-node=\"0\" data-path-to-node=\"14\"\u003eIUPAC Name:\u003c\/b\u003e (1E,6E)-1,7-bis(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione \u003cb data-index-in-node=\"80\" data-path-to-node=\"14\"\u003eFormat:\u003c\/b\u003e Crystalline Yellow-Orange Powder \u003cb data-index-in-node=\"121\" data-path-to-node=\"14\"\u003eClass:\u003c\/b\u003e Polyphenol (Diarylheptanoid) \u003cb data-index-in-node=\"157\" data-path-to-node=\"14\"\u003ePurity:\u003c\/b\u003e \u0026gt;98% (HPLC) \u003cb data-index-in-node=\"177\" data-path-to-node=\"14\"\u003eContent:\u003c\/b\u003e 600mg per jar \u003cb data-index-in-node=\"200\" data-path-to-node=\"14\"\u003eSolubility:\u003c\/b\u003e DMSO, Ethanol (Practically insoluble in water)\u003cbr\u003e\u003c\/p\u003e\n\u003chr data-path-to-node=\"16\"\u003e\n\u003ch3 data-path-to-node=\"17\"\u003e\u003cb data-index-in-node=\"0\" data-path-to-node=\"17\"\u003eProduct Overview\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp data-path-to-node=\"18\"\u003e\u003cb data-index-in-node=\"0\" data-path-to-node=\"18\"\u003eCurcumin\u003c\/b\u003e is the principal bioactive curcuminoid isolated from \u003ci data-index-in-node=\"62\" data-path-to-node=\"18\"\u003eCurcuma longa\u003c\/i\u003e. Unlike the peptides found in our catalog, Curcumin is a \u003cb data-index-in-node=\"133\" data-path-to-node=\"18\"\u003ehydrophobic polyphenol\u003c\/b\u003e characterized by its pleiotropic ability to modulate multiple cell signaling pathways simultaneously.\u003c\/p\u003e\n\u003cp data-path-to-node=\"19\"\u003eThis \u003cb data-index-in-node=\"5\" data-path-to-node=\"19\"\u003e600mg Research-Grade\u003c\/b\u003e formulation is scaled to accommodate the molecule's specific pharmacokinetic profile. Due to extensive first-pass metabolism and low systemic bioavailability, high-concentration research protocols are often required to achieve pharmacologically relevant serum levels for \u003ci data-index-in-node=\"297\" data-path-to-node=\"19\"\u003ein vitro\u003c\/i\u003e and \u003ci data-index-in-node=\"310\" data-path-to-node=\"19\"\u003ein vivo\u003c\/i\u003e investigation. It is a potent probe for dissecting inflammatory cascades, amyloid pathology, and oncological signaling.\u003c\/p\u003e\n\u003chr data-path-to-node=\"20\"\u003e\n\u003ch3 data-path-to-node=\"21\"\u003e\u003cb data-index-in-node=\"0\" data-path-to-node=\"21\"\u003eMechanism of Action: The Master Switch\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp data-path-to-node=\"22\"\u003eCurcumin acts as a broad-spectrum modulator of the inflammatory genome, intercepting pathogenic signals at the transcriptional level.\u003c\/p\u003e\n\u003cul data-path-to-node=\"23\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"23,0,0\"\u003e\u003cb data-index-in-node=\"0\" data-path-to-node=\"23,0,0\"\u003eNF-κB Suppression:\u003c\/b\u003e It directly inhibits IKKβ, preventing the phosphorylation of IκBα. This sequesters the transcription factor NF-κB in the cytoplasm, halting the production of inflammatory cytokines (TNF-α, IL-6).\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"23,1,0\"\u003e\u003cb data-index-in-node=\"0\" data-path-to-node=\"23,1,0\"\u003eDual Eicosanoid Inhibition:\u003c\/b\u003e Uniquely acts as a dual inhibitor of both \u003cb data-index-in-node=\"70\" data-path-to-node=\"23,1,0\"\u003eCOX-2\u003c\/b\u003e (prostaglandins) and \u003cb data-index-in-node=\"97\" data-path-to-node=\"23,1,0\"\u003e5-LOX\u003c\/b\u003e (leukotrienes), shutting down arachidonic acid metabolism without the gastric toxicity associated with COX-1 inhibition.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"23,2,0\"\u003e\u003cb data-index-in-node=\"0\" data-path-to-node=\"23,2,0\"\u003eAntioxidant (Nrf2):\u003c\/b\u003e Activates the Nrf2 pathway, driving the expression of cytoprotective enzymes like Heme Oxygenase-1 (HO-1) and Superoxide Dismutase (SOD).\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003chr data-path-to-node=\"24\"\u003e\n\u003ch3 data-path-to-node=\"25\"\u003e\u003cb data-index-in-node=\"0\" data-path-to-node=\"25\"\u003eKey Research Applications\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp data-path-to-node=\"26\"\u003e\u003cb data-index-in-node=\"0\" data-path-to-node=\"26\"\u003e1. Autoimmunity \u0026amp; Inflammation (Arthritis)\u003c\/b\u003e In Collagen-Induced Arthritis (CIA) models, Curcumin demonstrates significant anti-inflammatory activity.\u003c\/p\u003e\n\u003cul data-path-to-node=\"27\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"27,0,0\"\u003e\u003cb data-index-in-node=\"0\" data-path-to-node=\"27,0,0\"\u003eEdema Reduction:\u003c\/b\u003e High-dose protocols suppressed paw edema by ~58%, comparable to standard NSAIDs but with a delayed onset of action consistent with genomic regulation.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"27,1,0\"\u003e\u003cb data-index-in-node=\"0\" data-path-to-node=\"27,1,0\"\u003eJoint Preservation:\u003c\/b\u003e Downregulates MMP-1 and MMP-3, preventing the enzymatic degradation of cartilage architecture.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp data-path-to-node=\"28\"\u003e\u003cb data-index-in-node=\"0\" data-path-to-node=\"28\"\u003e2. Neurodegeneration (Alzheimer's \u0026amp; BDNF)\u003c\/b\u003e Curcumin is lipophilic and crosses the Blood-Brain Barrier (BBB).\u003c\/p\u003e\n\u003cul data-path-to-node=\"29\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"29,0,0\"\u003e\u003cb data-index-in-node=\"0\" data-path-to-node=\"29,0,0\"\u003eAmyloid Clearance:\u003c\/b\u003e Enhances macrophage phagocytosis of Amyloid-β plaques and inhibits fibril aggregation.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"29,1,0\"\u003e\u003cb data-index-in-node=\"0\" data-path-to-node=\"29,1,0\"\u003eBDNF Restoration:\u003c\/b\u003e In models of depression and cognitive decline, it restores brain levels of \u003cb data-index-in-node=\"93\" data-path-to-node=\"29,1,0\"\u003eBrain-Derived Neurotrophic Factor (BDNF)\u003c\/b\u003e to near-wild-type levels, promoting neuroplasticity.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp data-path-to-node=\"30\"\u003e\u003cb data-index-in-node=\"0\" data-path-to-node=\"30\"\u003e3. Oncology (Chemosensitization)\u003c\/b\u003e Investigated for its ability to reverse Multi-Drug Resistance (MDR). In colorectal and breast cancer xenografts, Curcumin potentiates the effects of chemotherapeutics (like 5-FU), significantly reducing tumor volume via apoptosis induction (Bcl-2 downregulation).\u003c\/p\u003e\n\u003chr data-path-to-node=\"31\"\u003e\n\u003ch3 data-path-to-node=\"32\"\u003e\u003cb data-index-in-node=\"0\" data-path-to-node=\"32\"\u003eHandling \u0026amp; Bioavailability\u003c\/b\u003e\u003c\/h3\u003e\n\u003cul data-path-to-node=\"33\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"33,0,0\"\u003e\u003cb data-index-in-node=\"0\" data-path-to-node=\"33,0,0\"\u003eClassification:\u003c\/b\u003e \u003cb data-index-in-node=\"16\" data-path-to-node=\"33,0,0\"\u003eNOT A PEPTIDE.\u003c\/b\u003e This is a lipophilic polyphenol.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"33,1,0\"\u003e\u003cb data-index-in-node=\"0\" data-path-to-node=\"33,1,0\"\u003eSolubility:\u003c\/b\u003e Insoluble in water. Must be solubilized in organic solvents like \u003cb data-index-in-node=\"77\" data-path-to-node=\"33,1,0\"\u003eDMSO\u003c\/b\u003e (\u0026gt;11 mg\/mL) or \u003cb data-index-in-node=\"97\" data-path-to-node=\"33,1,0\"\u003eEthanol\u003c\/b\u003e for stock solutions.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"33,2,0\"\u003e\u003cb data-index-in-node=\"0\" data-path-to-node=\"33,2,0\"\u003eBioavailability:\u003c\/b\u003e Poor systemic absorption. Research often utilizes advanced carriers (PLGA nanoparticles, liposomes, or phytosomes) or high-dose protocols (like this 600mg quantity) to overcome rapid glucuronidation.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"33,3,0\"\u003e\u003cb data-index-in-node=\"0\" data-path-to-node=\"33,3,0\"\u003eStability:\u003c\/b\u003e Light sensitive. Store in amber vials at -20°C to prevent oxidative degradation. Unstable in alkaline buffers (pH \u0026gt; 7).\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003chr data-path-to-node=\"34\"\u003e\n\u003ch3 data-path-to-node=\"35\"\u003e\u003cb data-index-in-node=\"0\" data-path-to-node=\"35\"\u003eDisclaimer\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp data-path-to-node=\"36\"\u003e\u003cb data-index-in-node=\"0\" data-path-to-node=\"36\"\u003eFOR RESEARCH USE ONLY.\u003c\/b\u003e This product is a chemical compound intended strictly for laboratory research and development. It is not approved by the FDA for clinical use, diagnostics, or therapeutic procedures in humans or animals. The physiological and toxicological properties of this chemical have not been fully investigated.\u003c\/p\u003e","brand":"Peptagon","offers":[{"title":"Default Title","offer_id":47710005067990,"sku":"CURCUMIN-600","price":132.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0783\/3085\/5638\/files\/Curcumin-600mg_ae839c76-d94c-4ed2-813d-2a770b8b2ba9.png?v=1768510191"},{"product_id":"dsip-delta-sleep-inducing-research-peptide","title":"DSIP Research Peptide – 5mg","description":"\u003ch4 data-path-to-node=\"13\"\u003e\u003cstrong\u003eDSIP (Delta Sleep-Inducing Peptide) Lyophilized\u003c\/strong\u003e\u003c\/h4\u003e\n\u003cp data-path-to-node=\"14\"\u003e\u003cb data-path-to-node=\"14\" data-index-in-node=\"0\"\u003eSequence:\u003c\/b\u003e Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu (WAGGDASGE) \u003cb data-path-to-node=\"14\" data-index-in-node=\"58\"\u003eFormat:\u003c\/b\u003e Sterile Lyophilized Powder (Vial) \u003cb data-path-to-node=\"14\" data-index-in-node=\"100\"\u003eMolecular Weight:\u003c\/b\u003e ~848.8 Da \u003cb data-path-to-node=\"14\" data-index-in-node=\"128\"\u003ePurity:\u003c\/b\u003e \u0026gt;98% (HPLC) \u003cb data-path-to-node=\"14\" data-index-in-node=\"148\"\u003eContent:\u003c\/b\u003e 5mg per vial\u003c\/p\u003e\n\u003chr data-path-to-node=\"15\"\u003e\n\u003ch3 data-path-to-node=\"16\"\u003e\u003cb data-path-to-node=\"16\" data-index-in-node=\"0\"\u003eProduct Overview\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp data-path-to-node=\"17\"\u003e\u003cb data-path-to-node=\"17\" data-index-in-node=\"0\"\u003eDSIP (Delta Sleep-Inducing Peptide)\u003c\/b\u003e is a naturally occurring nonapeptide first isolated from the cerebral venous blood of rabbits during slow-wave sleep. It is characterized by its unique ability to modulate the sleep-wake cycle and physiological stress responses.\u003c\/p\u003e\n\u003cp data-path-to-node=\"18\"\u003eUnlike conventional sedatives, DSIP does not merely induce sleep but functions as a \u003cb data-path-to-node=\"18\" data-index-in-node=\"84\"\u003ehomeostatic regulator\u003c\/b\u003e. Research indicates it tunes the sensitivity of multiple physiological axes—including the HPA axis and antioxidant systems—to promote adaptation, resilience, and the restoration of natural circadian rhythms. It is widely investigated for its potential in treating sleep deprivation, chronic stress, and age-related metabolic decline.\u003c\/p\u003e\n\u003chr data-path-to-node=\"19\"\u003e\n\u003ch3 data-path-to-node=\"20\"\u003e\u003cb data-path-to-node=\"20\" data-index-in-node=\"0\"\u003eMechanism of Action: The Homeostatic Regulator\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp data-path-to-node=\"21\"\u003eDSIP operates via a complex network of signaling pathways rather than a single receptor target.\u003c\/p\u003e\n\u003cul data-path-to-node=\"22\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"22,0,0\"\u003e\u003cb data-path-to-node=\"22,0,0\" data-index-in-node=\"0\"\u003eSleep Architecture:\u003c\/b\u003e Promotes \u003cb data-path-to-node=\"22,0,0\" data-index-in-node=\"29\"\u003eSlow-Wave Sleep (SWS)\u003c\/b\u003e and, uniquely, enhances \u003cb data-path-to-node=\"22,0,0\" data-index-in-node=\"75\"\u003eREM sleep\u003c\/b\u003e. This contrasts with many pharmacological agents that suppress REM. It is believed to interact with the Suprachiasmatic Nucleus (SCN) to reset circadian clocks.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"22,1,0\"\u003e\u003cb data-path-to-node=\"22,1,0\" data-index-in-node=\"0\"\u003eStress Modulation (HPA Axis):\u003c\/b\u003e Acts as a \"brake\" on the stress response. It reduces basal levels of ACTH and blocks Corticotropin-Releasing Factor (CRF)-induced corticosterone release, mitigating the catabolic effects of chronic stress.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"22,2,0\"\u003e\u003cb data-path-to-node=\"22,2,0\" data-index-in-node=\"0\"\u003eAntioxidant Defense:\u003c\/b\u003e Upregulates endogenous antioxidant enzymes such as \u003cb data-path-to-node=\"22,2,0\" data-index-in-node=\"72\"\u003eSuperoxide Dismutase (SOD)\u003c\/b\u003e and \u003cb data-path-to-node=\"22,2,0\" data-index-in-node=\"103\"\u003eGlutathione Peroxidase (GPx)\u003c\/b\u003e, reducing lipid peroxidation and mitochondrial stress.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003chr data-path-to-node=\"23\"\u003e\n\u003ch3 data-path-to-node=\"24\"\u003e\u003cb data-path-to-node=\"24\" data-index-in-node=\"0\"\u003eKey Research Applications\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp data-path-to-node=\"25\"\u003e\u003cb data-path-to-node=\"25\" data-index-in-node=\"0\"\u003e1. Sleep Deprivation \u0026amp; Circadian Rhythm\u003c\/b\u003e In animal models, administration of DSIP restores the \"rebound\" of Slow-Wave Sleep following sleep deprivation. Blocking endogenous DSIP with antibodies abolishes this restorative response, confirming its physiological necessity.\u003c\/p\u003e\n\u003cp data-path-to-node=\"26\"\u003e\u003cb data-path-to-node=\"26\" data-index-in-node=\"0\"\u003e2. Neuroprotection \u0026amp; Excitotoxicity\u003c\/b\u003e DSIP modulates the balance between excitation and inhibition in the brain. It blocks NMDA-mediated excitotoxicity (calcium overload) while potentiating GABAergic transmission, offering neuroprotective benefits against oxidative stress and glutamate storms.\u003c\/p\u003e\n\u003cp data-path-to-node=\"27\"\u003e\u003cb data-path-to-node=\"27\" data-index-in-node=\"0\"\u003e3. Geroprotection (Anti-Aging)\u003c\/b\u003e Long-term studies (e.g., using the \"Deltaran\" preparation) have demonstrated profound geroprotective effects. Lifespan studies in mice showed a \u003cb data-path-to-node=\"27\" data-index-in-node=\"175\"\u003e24.1% increase in maximum lifespan\u003c\/b\u003e and a \u003cb data-path-to-node=\"27\" data-index-in-node=\"216\"\u003e2.6-fold decrease in spontaneous tumor incidence\u003c\/b\u003e, attributed to enhanced genomic stability and reduced metabolic stress.\u003c\/p\u003e\n\u003cp data-path-to-node=\"28\"\u003e\u003cb data-path-to-node=\"28\" data-index-in-node=\"0\"\u003e4. Withdrawal \u0026amp; Analgesia\u003c\/b\u003e Investigated for its ability to reset homeostatic set points in addiction models, alleviating withdrawal symptoms in opiate and alcohol dependence. It also exhibits non-opioid analgesic properties, elevating pain thresholds via circadian modulation.\u003c\/p\u003e\n\u003chr data-path-to-node=\"29\"\u003e\n\u003ch3 data-path-to-node=\"30\"\u003e\u003cb data-path-to-node=\"30\" data-index-in-node=\"0\"\u003eStorage \u0026amp; Handling\u003c\/b\u003e\u003c\/h3\u003e\n\u003cul data-path-to-node=\"31\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"31,0,0\"\u003e\u003cb data-path-to-node=\"31,0,0\" data-index-in-node=\"0\"\u003ePhysical State:\u003c\/b\u003e Lyophilized (Freeze-Dried) White Powder.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"31,1,0\"\u003e\u003cb data-path-to-node=\"31,1,0\" data-index-in-node=\"0\"\u003eStorage (Powder):\u003c\/b\u003e Store at -20°C (Freezer). Stable for up to 24 months.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"31,2,0\"\u003e\u003cb data-path-to-node=\"31,2,0\" data-index-in-node=\"0\"\u003eReconstitution:\u003c\/b\u003e\u003c\/p\u003e\n\u003cul data-path-to-node=\"31,2,1\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"31,2,1,0,0\"\u003e\u003cb data-path-to-node=\"31,2,1,0,0\" data-index-in-node=\"0\"\u003eSolvent:\u003c\/b\u003e Bacteriostatic Water or Sterile Saline.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"31,2,1,1,0\"\u003e\u003cb data-path-to-node=\"31,2,1,1,0\" data-index-in-node=\"0\"\u003eSolubility:\u003c\/b\u003e Highly soluble in water.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"31,3,0\"\u003e\u003cb data-path-to-node=\"31,3,0\" data-index-in-node=\"0\"\u003eStorage (Reconstituted):\u003c\/b\u003e Store at 4°C (Refrigerator). Use within 14 days. \u003cb data-path-to-node=\"31,3,0\" data-index-in-node=\"74\"\u003eAvoid freeze-thaw cycles.\u003c\/b\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003chr data-path-to-node=\"32\"\u003e\n\u003ch3 data-path-to-node=\"33\"\u003e\u003cb data-path-to-node=\"33\" data-index-in-node=\"0\"\u003eDisclaimer\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp data-path-to-node=\"34\"\u003e\u003cb data-path-to-node=\"34\" data-index-in-node=\"0\"\u003eFOR RESEARCH USE ONLY.\u003c\/b\u003e This product is a chemical compound intended strictly for laboratory research and development. It is not approved by the FDA for clinical use, diagnostics, or therapeutic procedures in humans or animals. The physiological and toxicological properties of this chemical have not been fully investigated.\u003c\/p\u003e","brand":"Peptagon","offers":[{"title":"Default Title","offer_id":47710005100758,"sku":"DSIP-5","price":28.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0783\/3085\/5638\/files\/DSIP-5mg.png?v=1768511106"},{"product_id":"epithalon-aedg-tetrapeptide-research-peptide","title":"Epithalon Research Peptide – 10mg \/ 50mg","description":"\u003ch4 data-path-to-node=\"13\"\u003e\u003cstrong\u003eEpithalon Peptide (Lyophilized)\u003c\/strong\u003e\u003c\/h4\u003e\n\u003cp data-path-to-node=\"14\"\u003e\u003cb data-path-to-node=\"14\" data-index-in-node=\"0\"\u003eSequence:\u003c\/b\u003e Ala-Glu-Asp-Gly (AEDG) \u003cb data-path-to-node=\"14\" data-index-in-node=\"33\"\u003eFormat:\u003c\/b\u003e Sterile Lyophilized Powder (Vial) \u003cb data-path-to-node=\"14\" data-index-in-node=\"75\"\u003eClass:\u003c\/b\u003e Synthetic Peptide Bioregulator (Pineal Mimetic) \u003cb data-path-to-node=\"14\" data-index-in-node=\"130\"\u003ePurity:\u003c\/b\u003e \u0026gt;98% (HPLC) \u003cb data-path-to-node=\"14\" data-index-in-node=\"150\"\u003eContent:\u003c\/b\u003e Available in 10mg and 50mg vials\u003c\/p\u003e\n\u003chr data-path-to-node=\"15\"\u003e\n\u003ch3 data-path-to-node=\"16\"\u003e\u003cb data-path-to-node=\"16\" data-index-in-node=\"0\"\u003eProduct Overview\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp data-path-to-node=\"17\"\u003e\u003cb data-path-to-node=\"17\" data-index-in-node=\"0\"\u003eEpithalon\u003c\/b\u003e (also known as Epitalon or AEDG) is a synthetic tetrapeptide designed to mimic the biological activity of Epithalamin, a pineal gland extract. It is a foundational compound in the field of \"bioregulator\" peptides.\u003c\/p\u003e\n\u003cp data-path-to-node=\"18\"\u003eUnlike its naturally derived precursor, Epithalon is a single, precise molecular entity (Ala-Glu-Asp-Gly). Its primary research significance lies in its capacity to activate the enzyme \u003cb data-path-to-node=\"18\" data-index-in-node=\"185\"\u003etelomerase\u003c\/b\u003e (specifically the catalytic subunit hTERT) and modulate chromatin structure. It is extensively studied for its potential to extend replicative lifespan, regulate circadian rhythms, and influence geroprotective gene expression.\u003c\/p\u003e\n\u003chr data-path-to-node=\"19\"\u003e\n\u003ch3 data-path-to-node=\"20\"\u003e\u003cb data-path-to-node=\"20\" data-index-in-node=\"0\"\u003eMechanism of Action: Epigenetic Telomerase Activation\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp data-path-to-node=\"21\"\u003eEpithalon functions as an epigenetic modulator, interacting directly with the genome rather than cell surface receptors.\u003c\/p\u003e\n\u003cul data-path-to-node=\"22\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"22,0,0\"\u003e\u003cb data-path-to-node=\"22,0,0\" data-index-in-node=\"0\"\u003eChromatin Decondensation:\u003c\/b\u003e It binds to specific histone proteins (H1\/3, H1\/6), relaxing condensed chromatin (heterochromatin). This \"unlocks\" silenced genes associated with protein synthesis and cellular repair.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"22,1,0\"\u003e\u003cb data-path-to-node=\"22,1,0\" data-index-in-node=\"0\"\u003eTelomerase Upregulation:\u003c\/b\u003e By reactivating the \u003ci data-path-to-node=\"22,1,0\" data-index-in-node=\"45\"\u003ehTERT\u003c\/i\u003e gene, Epithalon induces telomere elongation. In human fibroblast cultures, this has been shown to extend the \"Hayflick limit\" (the number of times a cell can divide) by over 10 passages.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"22,2,0\"\u003e\u003cb data-path-to-node=\"22,2,0\" data-index-in-node=\"0\"\u003eGene Regulation:\u003c\/b\u003e Downregulates senescence markers like \u003cb data-path-to-node=\"22,2,0\" data-index-in-node=\"55\"\u003ep16 (INK4a)\u003c\/b\u003e and \u003cb data-path-to-node=\"22,2,0\" data-index-in-node=\"71\"\u003ep21 (Waf1)\u003c\/b\u003e, delaying cellular aging.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003chr data-path-to-node=\"23\"\u003e\n\u003ch3 data-path-to-node=\"24\"\u003e\u003cb data-path-to-node=\"24\" data-index-in-node=\"0\"\u003eKey Research Applications\u003c\/b\u003e\u003c\/h3\u003e\n\u003ch4 data-path-to-node=\"25\"\u003e\u003cb data-path-to-node=\"25\" data-index-in-node=\"0\"\u003e1. Longevity \u0026amp; Geroprotection\u003c\/b\u003e\u003c\/h4\u003e\n\u003cp data-path-to-node=\"26\"\u003eLongitudinal studies (Khavinson et al.) in rodents have demonstrated that Epithalon can increase maximum lifespan by \u003cb data-path-to-node=\"26\" data-index-in-node=\"117\"\u003e11-25%\u003c\/b\u003e.\u003c\/p\u003e\n\u003cul data-path-to-node=\"27\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"27,0,0\"\u003e\u003cb data-path-to-node=\"27,0,0\" data-index-in-node=\"0\"\u003eMortality Reduction:\u003c\/b\u003e In long-term human observations (15 years), pineal peptide preparations were associated with a significant reduction in all-cause mortality.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"27,1,0\"\u003e\u003cb data-path-to-node=\"27,1,0\" data-index-in-node=\"0\"\u003eCircadian Rhythm:\u003c\/b\u003e Restores the youthful secretion of melatonin and normalizes cortisol levels in aged primate models.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch4 data-path-to-node=\"28\"\u003e\u003cb data-path-to-node=\"28\" data-index-in-node=\"0\"\u003e2. Oncology (Tumor Inhibition)\u003c\/b\u003e\u003c\/h4\u003e\n\u003cp data-path-to-node=\"29\"\u003eContradicting the fear that telomerase activation promotes cancer, Epithalon has shown \u003cb data-path-to-node=\"29\" data-index-in-node=\"87\"\u003eoncostatic\u003c\/b\u003e effects.\u003c\/p\u003e\n\u003cul data-path-to-node=\"30\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"30,0,0\"\u003e\u003cb data-path-to-node=\"30,0,0\" data-index-in-node=\"0\"\u003eTumor Suppression:\u003c\/b\u003e In rats with M-1 sarcoma, it inhibited tumor growth and induced \"hemorrhagic necrosis\" of the tumor mass.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"30,1,0\"\u003e\u003cb data-path-to-node=\"30,1,0\" data-index-in-node=\"0\"\u003eHER-2\/neu Suppression:\u003c\/b\u003e In transgenic mice, it downregulated the breast cancer oncogene \u003ci data-path-to-node=\"30,1,0\" data-index-in-node=\"87\"\u003eHER-2\/neu\u003c\/i\u003e, reducing tumor incidence and size.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch4 data-path-to-node=\"31\"\u003e\u003cb data-path-to-node=\"31\" data-index-in-node=\"0\"\u003e3. Retinal Repair\u003c\/b\u003e\u003c\/h4\u003e\n\u003cp data-path-to-node=\"32\"\u003eInvestigated for its ability to restore retinal function in degenerative conditions like Retinitis Pigmentosa.\u003c\/p\u003e\n\u003cul data-path-to-node=\"33\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"33,0,0\"\u003e\u003cb data-path-to-node=\"33,0,0\" data-index-in-node=\"0\"\u003eFunctional Recovery:\u003c\/b\u003e In rat models, it preserved retinal structure and increased electroretinogram (ERG) amplitude by ~75%.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003chr data-path-to-node=\"34\"\u003e\n\u003ch3 data-path-to-node=\"35\"\u003e\u003cb data-path-to-node=\"35\" data-index-in-node=\"0\"\u003eStorage \u0026amp; Handling\u003c\/b\u003e\u003c\/h3\u003e\n\u003cul data-path-to-node=\"36\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"36,0,0\"\u003e\u003cb data-path-to-node=\"36,0,0\" data-index-in-node=\"0\"\u003ePhysical State:\u003c\/b\u003e Lyophilized (Freeze-Dried) Powder.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"36,1,0\"\u003e\u003cb data-path-to-node=\"36,1,0\" data-index-in-node=\"0\"\u003eStorage (Powder):\u003c\/b\u003e Store at -20°C (Freezer). Stable for up to 24 months.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"36,2,0\"\u003e\u003cb data-path-to-node=\"36,2,0\" data-index-in-node=\"0\"\u003eReconstitution:\u003c\/b\u003e\u003c\/p\u003e\n\u003cul data-path-to-node=\"36,2,1\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"36,2,1,0,0\"\u003e\u003cb data-path-to-node=\"36,2,1,0,0\" data-index-in-node=\"0\"\u003eSolvent:\u003c\/b\u003e Bacteriostatic Water or Sterile Saline.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"36,2,1,1,0\"\u003e\u003cb data-path-to-node=\"36,2,1,1,0\" data-index-in-node=\"0\"\u003eSolubility:\u003c\/b\u003e Highly hydrophilic and soluble.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"36,3,0\"\u003e\u003cb data-path-to-node=\"36,3,0\" data-index-in-node=\"0\"\u003eStorage (Liquid):\u003c\/b\u003e Store at 4°C (Refrigerator). Use within 14-21 days.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003chr data-path-to-node=\"37\"\u003e\n\u003ch3 data-path-to-node=\"38\"\u003e\u003cb data-path-to-node=\"38\" data-index-in-node=\"0\"\u003eDisclaimer\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp data-path-to-node=\"39\"\u003e\u003cb data-path-to-node=\"39\" data-index-in-node=\"0\"\u003eFOR RESEARCH USE ONLY.\u003c\/b\u003e This product is a chemical compound intended strictly for laboratory research and development. It is not approved by the FDA for clinical use, diagnostics, or therapeutic procedures in humans or animals. The physiological and toxicological properties of this chemical have not been fully investigated.\u003c\/p\u003e","brand":"Peptagon","offers":[{"title":"10mg","offer_id":47710043111638,"sku":"EPITH-10","price":31.0,"currency_code":"USD","in_stock":true},{"title":"50mg","offer_id":47710043144406,"sku":"EPITH-50","price":54.0,"currency_code":"USD","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0783\/3085\/5638\/files\/Epithalon-10mg.png?v=1768510212"},{"product_id":"follistatin-344-fs344-myostatin-research-protein","title":"Follistatin 344 Research Protein – 1mg","description":"\u003ch4 data-path-to-node=\"13\"\u003e\u003cstrong\u003eFollistatin 344 (FS344) Peptide\u003c\/strong\u003e\u003c\/h4\u003e\n\u003cp data-path-to-node=\"14\"\u003e\u003cb data-path-to-node=\"14\" data-index-in-node=\"0\"\u003eIsoform:\u003c\/b\u003e Follistatin-315 (FS315) - Systemic Isoform \u003cb data-path-to-node=\"14\" data-index-in-node=\"52\"\u003eFormat:\u003c\/b\u003e Sterile Lyophilized Powder (Vial) \u003cb data-path-to-node=\"14\" data-index-in-node=\"94\"\u003eMechanism:\u003c\/b\u003e High-Affinity Ligand Trap (TGF-β Superfamily) \u003cb data-path-to-node=\"14\" data-index-in-node=\"151\"\u003ePurity:\u003c\/b\u003e \u0026gt;95% (HPLC) \u003cb data-path-to-node=\"14\" data-index-in-node=\"171\"\u003eContent:\u003c\/b\u003e 1mg per vial\u003c\/p\u003e\n\u003chr data-path-to-node=\"15\"\u003e\n\u003ch3 data-path-to-node=\"16\"\u003e\u003cb data-path-to-node=\"16\" data-index-in-node=\"0\"\u003eProduct Overview\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp data-path-to-node=\"17\"\u003e\u003cb data-path-to-node=\"17\" data-index-in-node=\"0\"\u003eFollistatin 344\u003c\/b\u003e is a recombinant glycoprotein designed to inhibit members of the TGF-β superfamily, most notably \u003cb data-path-to-node=\"17\" data-index-in-node=\"113\"\u003eMyostatin (GDF-8)\u003c\/b\u003e and \u003cb data-path-to-node=\"17\" data-index-in-node=\"135\"\u003eActivin A\u003c\/b\u003e. It corresponds to the alternatively spliced transcript that encodes the \u003cb data-path-to-node=\"17\" data-index-in-node=\"218\"\u003eFS315\u003c\/b\u003e isoform.\u003c\/p\u003e\n\u003cp data-path-to-node=\"18\"\u003eUnlike the tissue-bound FS288 isoform, Follistatin 344 contains an acidic C-terminal tail that masks its heparin-binding site. This modification allows it to circulate freely in the bloodstream, making it the preferred reagent for research requiring systemic muscle hypertrophy and metabolic modulation.\u003c\/p\u003e\n\u003chr data-path-to-node=\"19\"\u003e\n\u003ch3 data-path-to-node=\"20\"\u003e\u003cb data-path-to-node=\"20\" data-index-in-node=\"0\"\u003eMechanism of Action: The Ligand Trap\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp data-path-to-node=\"21\"\u003eFollistatin 344 acts as a \"molecular clamp,\" physically sequestering ligands to prevent them from binding to their receptors (ActRIIB).\u003c\/p\u003e\n\u003cul data-path-to-node=\"22\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"22,0,0\"\u003e\u003cb data-path-to-node=\"22,0,0\" data-index-in-node=\"0\"\u003eMyostatin Inhibition:\u003c\/b\u003e By neutralizing Myostatin, the primary negative regulator of muscle mass, Follistatin releases the \"brake\" on muscle growth, driving hypertrophy via the activation of mTOR and satellite cell fusion.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"22,1,0\"\u003e\u003cb data-path-to-node=\"22,1,0\" data-index-in-node=\"0\"\u003eActivin A Blockade:\u003c\/b\u003e Follistatin binds Activin A with even higher affinity than Myostatin. This is crucial for its anti-inflammatory effects and its ability to suppress fibrosis in models of muscular dystrophy.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"22,2,0\"\u003e\u003cb data-path-to-node=\"22,2,0\" data-index-in-node=\"0\"\u003eWnt Signaling:\u003c\/b\u003e In hair follicle research, it antagonizes BMPs to permit Wnt-mediated transition from the resting (telogen) to growth (anagen) phase.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003chr data-path-to-node=\"23\"\u003e\n\u003ch3 data-path-to-node=\"24\"\u003e\u003cb data-path-to-node=\"24\" data-index-in-node=\"0\"\u003eKey Research Applications\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp data-path-to-node=\"25\"\u003e\u003cb data-path-to-node=\"25\" data-index-in-node=\"0\"\u003e1. Musculoskeletal Hypertrophy\u003c\/b\u003e Follistatin 344 is the gold standard for inducing rapid muscle growth.\u003c\/p\u003e\n\u003cul data-path-to-node=\"26\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"26,0,0\"\u003e\u003cb data-path-to-node=\"26,0,0\" data-index-in-node=\"0\"\u003eHypertrophy:\u003c\/b\u003e Studies report gains of \u003cb data-path-to-node=\"26,0,0\" data-index-in-node=\"37\"\u003e20% to \u0026gt;100%\u003c\/b\u003e in muscle mass depending on the model (e.g., AAV gene therapy vs. peptide).\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"26,1,0\"\u003e\u003cb data-path-to-node=\"26,1,0\" data-index-in-node=\"0\"\u003eFiber Type:\u003c\/b\u003e Drives a shift toward glycolytic (Type II) fibers, increasing force generation capacity.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp data-path-to-node=\"27\"\u003e\u003cb data-path-to-node=\"27\" data-index-in-node=\"0\"\u003e2. Disease Models (Dystrophy \u0026amp; SMA)\u003c\/b\u003e\u003c\/p\u003e\n\u003cul data-path-to-node=\"28\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"28,0,0\"\u003e\u003cb data-path-to-node=\"28,0,0\" data-index-in-node=\"0\"\u003eSpinal Muscular Atrophy (SMA):\u003c\/b\u003e In murine models, daily administration extended lifespan by ~30% and increased motor neuron survival.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"28,1,0\"\u003e\u003cb data-path-to-node=\"28,1,0\" data-index-in-node=\"0\"\u003eDuchenne Muscular Dystrophy:\u003c\/b\u003e Unlike myostatin-specific antibodies, Follistatin also blocks Activin A, significantly reducing \u003cb data-path-to-node=\"28,1,0\" data-index-in-node=\"125\"\u003efibrosis\u003c\/b\u003e (scar tissue) in dystrophic muscle.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp data-path-to-node=\"29\"\u003e\u003cb data-path-to-node=\"29\" data-index-in-node=\"0\"\u003e3. Inflammation \u0026amp; Metabolism\u003c\/b\u003e\u003c\/p\u003e\n\u003cul data-path-to-node=\"30\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"30,0,0\"\u003e\u003cb data-path-to-node=\"30,0,0\" data-index-in-node=\"0\"\u003eCytokine Storm:\u003c\/b\u003e Acts as a potent anti-inflammatory by neutralizing the Activin A surge seen in sepsis and endotoxemia.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"30,1,0\"\u003e\u003cb data-path-to-node=\"30,1,0\" data-index-in-node=\"0\"\u003eMetabolic Health:\u003c\/b\u003e Hypertrophied muscle acts as a glucose sink, improving insulin sensitivity and reducing visceral fat mass in obesity models.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003chr data-path-to-node=\"31\"\u003e\n\u003ch3 data-path-to-node=\"32\"\u003e\u003cb data-path-to-node=\"32\" data-index-in-node=\"0\"\u003eStorage \u0026amp; Handling\u003c\/b\u003e\u003c\/h3\u003e\n\u003cul data-path-to-node=\"33\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"33,0,0\"\u003e\u003cb data-path-to-node=\"33,0,0\" data-index-in-node=\"0\"\u003ePhysical State:\u003c\/b\u003e Lyophilized (Freeze-Dried) Powder.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"33,1,0\"\u003e\u003cb data-path-to-node=\"33,1,0\" data-index-in-node=\"0\"\u003eStorage (Powder):\u003c\/b\u003e Store at -20°C (Freezer). Stable for up to 12 months.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"33,2,0\"\u003e\u003cb data-path-to-node=\"33,2,0\" data-index-in-node=\"0\"\u003eReconstitution:\u003c\/b\u003e\u003c\/p\u003e\n\u003cul data-path-to-node=\"33,2,1\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"33,2,1,0,0\"\u003e\u003cb data-path-to-node=\"33,2,1,0,0\" data-index-in-node=\"0\"\u003eSolvent:\u003c\/b\u003e Bacteriostatic Water or Sterile PBS (pH 7.4).\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"33,2,1,1,0\"\u003e\u003cb data-path-to-node=\"33,2,1,1,0\" data-index-in-node=\"0\"\u003eCarrier Protein:\u003c\/b\u003e Recommended to add \u003cb data-path-to-node=\"33,2,1,1,0\" data-index-in-node=\"36\"\u003e0.1% BSA\u003c\/b\u003e or HSA to prevent adsorption to the vial wall.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"33,3,0\"\u003e\u003cb data-path-to-node=\"33,3,0\" data-index-in-node=\"0\"\u003eStorage (Liquid):\u003c\/b\u003e Store at 4°C. \u003cb data-path-to-node=\"33,3,0\" data-index-in-node=\"32\"\u003eDo not freeze-thaw repeatedly.\u003c\/b\u003e Use aliquots.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003chr data-path-to-node=\"34\"\u003e\n\u003ch3 data-path-to-node=\"35\"\u003e\u003cb data-path-to-node=\"35\" data-index-in-node=\"0\"\u003eDisclaimer\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp data-path-to-node=\"36\"\u003e\u003cb data-path-to-node=\"36\" data-index-in-node=\"0\"\u003eFOR RESEARCH USE ONLY.\u003c\/b\u003e This product is a chemical compound intended strictly for laboratory research and development. It is not approved by the FDA for clinical use, diagnostics, or therapeutic procedures in humans or animals. The physiological and toxicological properties of this chemical have not been fully investigated.\u003c\/p\u003e","brand":"Peptagon","offers":[{"title":"Default Title","offer_id":47710043406550,"sku":"FOLL344-1","price":120.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0783\/3085\/5638\/files\/Follistatin-344-1mg.png?v=1768509451"},{"product_id":"foxo4-dri-foxo4-p53-research-peptide","title":"FOXO4-DRI Research Peptide – 15mg","description":"\u003ch4 data-path-to-node=\"13\"\u003e\u003cstrong\u003eFOXO4-DRI Peptide (Lyophilized)\u003c\/strong\u003e\u003c\/h4\u003e\n\u003cp data-path-to-node=\"14\"\u003e\u003cb data-path-to-node=\"14\" data-index-in-node=\"0\"\u003eSequence:\u003c\/b\u003e D-Retro-Inverso Sequence (53 Amino Acids) \u003cb data-path-to-node=\"14\" data-index-in-node=\"52\"\u003eFormat:\u003c\/b\u003e Sterile Lyophilized Powder (Vial) \u003cb data-path-to-node=\"14\" data-index-in-node=\"94\"\u003eMechanism:\u003c\/b\u003e FOXO4\/p53 Interaction Antagonist \u003cb data-path-to-node=\"14\" data-index-in-node=\"138\"\u003ePurity:\u003c\/b\u003e \u0026gt;98% (HPLC) \u003cb data-path-to-node=\"14\" data-index-in-node=\"158\"\u003eContent:\u003c\/b\u003e 15mg per vial\u003c\/p\u003e\n\u003chr data-path-to-node=\"15\"\u003e\n\u003ch3 data-path-to-node=\"16\"\u003e\u003cb data-path-to-node=\"16\" data-index-in-node=\"0\"\u003eProduct Overview\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp data-path-to-node=\"17\"\u003e\u003cb data-path-to-node=\"17\" data-index-in-node=\"0\"\u003eFOXO4-DRI\u003c\/b\u003e is a breakthrough \"third-generation\" senolytic peptide engineered to selectively eliminate senescent cells (\"zombie cells\") that accumulate with aging. Unlike earlier broad-spectrum senolytics that can harm healthy tissue, FOXO4-DRI targets a molecular interaction unique to senescent cells.\u003c\/p\u003e\n\u003cp data-path-to-node=\"18\"\u003eIt utilizes \u003cb data-path-to-node=\"18\" data-index-in-node=\"12\"\u003eD-Retro-Inverso (DRI)\u003c\/b\u003e chemistry, meaning it is composed of D-amino acids in a reverse sequence. This modification renders the peptide resistant to enzymatic degradation, significantly extending its half-life and potency in vivo compared to standard L-peptides.\u003c\/p\u003e\n\u003chr data-path-to-node=\"19\"\u003e\n\u003ch3 data-path-to-node=\"20\"\u003e\u003cb data-path-to-node=\"20\" data-index-in-node=\"0\"\u003eMechanism of Action: The \"Senescence Pivot\"\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp data-path-to-node=\"21\"\u003eFOXO4-DRI works by disrupting the specific protein-protein interaction that keeps senescent cells alive.\u003c\/p\u003e\n\u003cul data-path-to-node=\"22\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"22,0,0\"\u003e\u003cb data-path-to-node=\"22,0,0\" data-index-in-node=\"0\"\u003eTargeting the p53-FOXO4 Axis:\u003c\/b\u003e In senescent cells, the protein FOXO4 binds to p53 and sequesters it in the nucleus, preventing p53 from triggering cell death. This keeps the damaged cell in a state of suspended animation.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"22,1,0\"\u003e\u003cb data-path-to-node=\"22,1,0\" data-index-in-node=\"0\"\u003eCompetitive Displacement:\u003c\/b\u003e FOXO4-DRI mimics the binding site of FOXO4. It binds to p53 with high affinity, displacing the endogenous FOXO4.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"22,2,0\"\u003e\u003cb data-path-to-node=\"22,2,0\" data-index-in-node=\"0\"\u003eApoptosis Initiation:\u003c\/b\u003e Once liberated, p53 translocates to the mitochondria and activates BAX\/BAK, triggering intrinsic apoptosis (cell death) specifically in the senescent cell. Healthy cells, which do not have elevated FOXO4-p53 complexes, are left unharmed.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003chr data-path-to-node=\"23\"\u003e\n\u003ch3 data-path-to-node=\"24\"\u003e\u003cb data-path-to-node=\"24\" data-index-in-node=\"0\"\u003eKey Research Applications\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp data-path-to-node=\"25\"\u003e\u003cb data-path-to-node=\"25\" data-index-in-node=\"0\"\u003e1. Systemic Rejuvenation\u003c\/b\u003e In landmark studies (Baar et al.), FOXO4-DRI administration in aged mice reversed signs of frailty, restored fur density, and improved renal function by clearing senescent cells from tissues.\u003c\/p\u003e\n\u003cp data-path-to-node=\"26\"\u003e\u003cb data-path-to-node=\"26\" data-index-in-node=\"0\"\u003e2. Organ Fibrosis\u003c\/b\u003e Investigated for its ability to target senescent myofibroblasts in pulmonary and renal fibrosis models. By removing these \"scar-forming\" cells, it improves tissue architecture and reduces collagen deposition.\u003c\/p\u003e\n\u003cp data-path-to-node=\"27\"\u003e\u003cb data-path-to-node=\"27\" data-index-in-node=\"0\"\u003e3. Chemotoxicity Rescue\u003c\/b\u003e Chemotherapy (e.g., Doxorubicin) induces widespread cellular senescence. Research shows FOXO4-DRI can rescue liver function and prevent cachexia (weight loss) caused by chemotherapy-induced senescence.\u003c\/p\u003e\n\u003cp data-path-to-node=\"28\"\u003e\u003cb data-path-to-node=\"28\" data-index-in-node=\"0\"\u003e4. Endocrine Restoration\u003c\/b\u003e In models of hypogonadism, the peptide eliminated senescent Leydig cells in the testes, restoring natural testosterone production and enzymatic function in aged subjects.\u003c\/p\u003e\n\u003chr data-path-to-node=\"29\"\u003e\n\u003ch3 data-path-to-node=\"30\"\u003e\u003cb data-path-to-node=\"30\" data-index-in-node=\"0\"\u003eStorage \u0026amp; Handling\u003c\/b\u003e\u003c\/h3\u003e\n\u003cul data-path-to-node=\"31\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"31,0,0\"\u003e\u003cb data-path-to-node=\"31,0,0\" data-index-in-node=\"0\"\u003ePhysical State:\u003c\/b\u003e Lyophilized (Freeze-Dried) Powder.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"31,1,0\"\u003e\u003cb data-path-to-node=\"31,1,0\" data-index-in-node=\"0\"\u003eStorage (Powder):\u003c\/b\u003e Store at -20°C (Freezer). Stable for up to 36 months.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"31,2,0\"\u003e\u003cb data-path-to-node=\"31,2,0\" data-index-in-node=\"0\"\u003eReconstitution:\u003c\/b\u003e\u003c\/p\u003e\n\u003cul data-path-to-node=\"31,2,1\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"31,2,1,0,0\"\u003e\u003cb data-path-to-node=\"31,2,1,0,0\" data-index-in-node=\"0\"\u003eSolvent:\u003c\/b\u003e Sterile PBS or Saline.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"31,2,1,1,0\"\u003e\u003cb data-path-to-node=\"31,2,1,1,0\" data-index-in-node=\"0\"\u003eSolubility:\u003c\/b\u003e Highly soluble due to cationic residues.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"31,3,0\"\u003e\u003cb data-path-to-node=\"31,3,0\" data-index-in-node=\"0\"\u003eStorage (Liquid):\u003c\/b\u003e Store at 4°C. \u003cb data-path-to-node=\"31,3,0\" data-index-in-node=\"32\"\u003eUse within 2-4 weeks.\u003c\/b\u003e The DRI modification improves stability, but reconstituted peptides naturally degrade over time.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003chr data-path-to-node=\"32\"\u003e\n\u003ch3 data-path-to-node=\"33\"\u003e\u003cb data-path-to-node=\"33\" data-index-in-node=\"0\"\u003eDisclaimer\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp data-path-to-node=\"34\"\u003e\u003cb data-path-to-node=\"34\" data-index-in-node=\"0\"\u003eFOR RESEARCH USE ONLY.\u003c\/b\u003e This product is a chemical compound intended strictly for laboratory research and development. It is not approved by the FDA for clinical use, diagnostics, or therapeutic procedures in humans or animals. The physiological and toxicological properties of this chemical have not been fully investigated.\u003c\/p\u003e","brand":"Peptagon","offers":[{"title":"Default Title","offer_id":47710043635926,"sku":"FOXO4-DRI-15","price":100.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0783\/3085\/5638\/files\/FOXO4-DRI-15mg.png?v=1768510316"},{"product_id":"ghk-cu-copper-tripeptide-1-research-peptide","title":"GHK-Cu Research Peptide – 50mg \/ 75mg \/ 100mg","description":"\u003ch4 data-path-to-node=\"13\"\u003e\u003cstrong\u003eGHK-Cu Peptide (Lyophilized)\u003c\/strong\u003e\u003c\/h4\u003e\n\u003cp data-path-to-node=\"14\"\u003e\u003cb data-path-to-node=\"14\" data-index-in-node=\"0\"\u003eSequence:\u003c\/b\u003e Glycyl-L-Histidyl-L-Lysine (Complexed with Copper Ion) \u003cb data-path-to-node=\"14\" data-index-in-node=\"65\"\u003eFormat:\u003c\/b\u003e Sterile Lyophilized Powder (Blue Cake) \u003cb data-path-to-node=\"14\" data-index-in-node=\"112\"\u003eMolecular Formula:\u003c\/b\u003e C14H24N6O4Cu \u003cb data-path-to-node=\"14\" data-index-in-node=\"144\"\u003ePurity:\u003c\/b\u003e \u0026gt;99% (HPLC) \u003cb data-path-to-node=\"14\" data-index-in-node=\"164\"\u003eContent:\u003c\/b\u003e Available in 50mg, 75mg, and 100mg vials\u003c\/p\u003e\n\u003chr data-path-to-node=\"15\"\u003e\n\u003ch3 data-path-to-node=\"16\"\u003e\u003cb data-path-to-node=\"16\" data-index-in-node=\"0\"\u003eProduct Overview\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp data-path-to-node=\"17\"\u003e\u003cb data-path-to-node=\"17\" data-index-in-node=\"0\"\u003eGHK-Cu\u003c\/b\u003e is a naturally occurring copper complex first isolated from human plasma. It functions as a powerful signaling peptide that declines significantly with age (from 200 ng\/mL at age 20 to 80 ng\/mL at age 60).\u003c\/p\u003e\n\u003cp data-path-to-node=\"18\"\u003eUnlike simple carrier peptides, GHK-Cu is a \u003cb data-path-to-node=\"18\" data-index-in-node=\"44\"\u003egenomic modulator\u003c\/b\u003e. Research utilizing the Broad Institute's Connectivity Map indicates it influences the expression of over 4,000 genes (~31% of the human genome), shifting gene signatures from a pathological state back to a healthier, regenerative baseline. It is the gold standard for research into skin remodeling, hair follicle stimulation, and wound healing.\u003c\/p\u003e\n\u003chr data-path-to-node=\"19\"\u003e\n\u003ch3 data-path-to-node=\"20\"\u003e\u003cb data-path-to-node=\"20\" data-index-in-node=\"0\"\u003eMechanism of Action: The \"Reset\" Switch\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp data-path-to-node=\"21\"\u003eGHK-Cu operates by coordinating copper (II) ions and delivering them into cells, where they act as cofactors for vital enzymes.\u003c\/p\u003e\n\u003cul data-path-to-node=\"22\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"22,0,0\"\u003e\u003cb data-path-to-node=\"22,0,0\" data-index-in-node=\"0\"\u003eGenomic Regulation:\u003c\/b\u003e It resets the gene expression of the \u003cb data-path-to-node=\"22,0,0\" data-index-in-node=\"57\"\u003eUbiquitin-Proteasome System (UPS)\u003c\/b\u003e, enhancing the cell's ability to clear toxic proteins (upregulating 41 UPS genes).\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"22,1,0\"\u003e\u003cb data-path-to-node=\"22,1,0\" data-index-in-node=\"0\"\u003eCollagen \u0026amp; Decorin:\u003c\/b\u003e It stimulates the synthesis of Collagen Types I and III. Uniquely, it also upregulates \u003cb data-path-to-node=\"22,1,0\" data-index-in-node=\"107\"\u003eDecorin\u003c\/b\u003e (by \u0026gt;300%), a proteoglycan that ensures collagen fibers form an organized lattice rather than disordered scar tissue.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"22,2,0\"\u003e\u003cb data-path-to-node=\"22,2,0\" data-index-in-node=\"0\"\u003eAntioxidant Defense:\u003c\/b\u003e Activates Superoxide Dismutase (SOD), neutralizing free radicals and reducing oxidative stress.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003chr data-path-to-node=\"23\"\u003e\n\u003ch3 data-path-to-node=\"24\"\u003e\u003cb data-path-to-node=\"24\" data-index-in-node=\"0\"\u003eKey Research Applications\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp data-path-to-node=\"25\"\u003e\u003cb data-path-to-node=\"25\" data-index-in-node=\"0\"\u003e1. Dermatology \u0026amp; Wound Healing\u003c\/b\u003e GHK-Cu is extensively studied for its ability to tighten loose skin and accelerate healing.\u003c\/p\u003e\n\u003cul data-path-to-node=\"26\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"26,0,0\"\u003e\u003cb data-path-to-node=\"26,0,0\" data-index-in-node=\"0\"\u003eRemodeling:\u003c\/b\u003e It modulates MMPs (Matrix Metalloproteinases) and TIMPs to remove damaged tissue and replace it with healthy ECM.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"26,1,0\"\u003e\u003cb data-path-to-node=\"26,1,0\" data-index-in-node=\"0\"\u003eClinical Efficacy:\u003c\/b\u003e In comparative studies, GHK-Cu reduced wrinkle depth by \u003cb data-path-to-node=\"26,1,0\" data-index-in-node=\"75\"\u003e32.8%\u003c\/b\u003e, outperforming other non-copper peptides like Matrixyl 3000.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp data-path-to-node=\"27\"\u003e\u003cb data-path-to-node=\"27\" data-index-in-node=\"0\"\u003e2. Trichology (Hair Growth)\u003c\/b\u003e Investigated as a potent hair growth stimulant.\u003c\/p\u003e\n\u003cul data-path-to-node=\"28\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"28,0,0\"\u003e\u003cb data-path-to-node=\"28,0,0\" data-index-in-node=\"0\"\u003eAngiogenesis:\u003c\/b\u003e Increases VEGF expression around the follicle, improving nutrient supply.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"28,1,0\"\u003e\u003cb data-path-to-node=\"28,1,0\" data-index-in-node=\"0\"\u003eFollicle Size:\u003c\/b\u003e Research indicates it enlarges follicle size and reverses miniaturization, pushing resting (telogen) follicles into the growth (anagen) phase faster than Minoxidil.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp data-path-to-node=\"29\"\u003e\u003cb data-path-to-node=\"29\" data-index-in-node=\"0\"\u003e3. Oncology (Metastasis Suppression)\u003c\/b\u003e Paradoxically, while regenerative, GHK-Cu has been shown to reverse the gene signature of metastatic colon cancer. It induces apoptosis in malignant cells by upregulating \u003cb data-path-to-node=\"29\" data-index-in-node=\"208\"\u003ep27kip1\u003c\/b\u003e and \u003cb data-path-to-node=\"29\" data-index-in-node=\"220\"\u003eCaspase-3\u003c\/b\u003e, acting as a \"smart\" molecule that supports healthy cells while targeting damaged ones.\u003c\/p\u003e\n\u003chr data-path-to-node=\"30\"\u003e\n\u003ch3 data-path-to-node=\"31\"\u003e\u003cb data-path-to-node=\"31\" data-index-in-node=\"0\"\u003eStorage \u0026amp; Handling\u003c\/b\u003e\u003c\/h3\u003e\n\u003cul data-path-to-node=\"32\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"32,0,0\"\u003e\u003cb data-path-to-node=\"32,0,0\" data-index-in-node=\"0\"\u003ePhysical State:\u003c\/b\u003e Lyophilized \u003cb data-path-to-node=\"32,0,0\" data-index-in-node=\"28\"\u003eBlue\u003c\/b\u003e Powder. (The blue color is natural due to copper coordination).\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"32,1,0\"\u003e\u003cb data-path-to-node=\"32,1,0\" data-index-in-node=\"0\"\u003eStorage (Powder):\u003c\/b\u003e Store at -20°C (Freezer). Stable for up to 24 months.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"32,2,0\"\u003e\u003cb data-path-to-node=\"32,2,0\" data-index-in-node=\"0\"\u003eReconstitution:\u003c\/b\u003e\u003c\/p\u003e\n\u003cul data-path-to-node=\"32,2,1\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"32,2,1,0,0\"\u003e\u003cb data-path-to-node=\"32,2,1,0,0\" data-index-in-node=\"0\"\u003eSolvent:\u003c\/b\u003e Bacteriostatic Water or Sterile Saline.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"32,2,1,1,0\"\u003e\u003cb data-path-to-node=\"32,2,1,1,0\" data-index-in-node=\"0\"\u003eSolubility:\u003c\/b\u003e Highly soluble (\u0026gt;50 mg\/mL).\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"32,2,1,2,0\"\u003e\u003cb data-path-to-node=\"32,2,1,2,0\" data-index-in-node=\"0\"\u003eConcentration:\u003c\/b\u003e For standard 1-2% topical research solutions, dilute the 100mg vial into 5-10mL of solvent.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"32,3,0\"\u003e\u003cb data-path-to-node=\"32,3,0\" data-index-in-node=\"0\"\u003eStorage (Liquid):\u003c\/b\u003e Store at 4°C (Refrigerator). Stable for ~1 month.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003chr data-path-to-node=\"33\"\u003e\n\u003ch3 data-path-to-node=\"34\"\u003e\u003cb data-path-to-node=\"34\" data-index-in-node=\"0\"\u003eDisclaimer\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp data-path-to-node=\"35\"\u003e\u003cb data-path-to-node=\"35\" data-index-in-node=\"0\"\u003eFOR RESEARCH USE ONLY.\u003c\/b\u003e This product is a chemical compound intended strictly for laboratory research and development. It is not approved by the FDA for clinical use, diagnostics, or therapeutic procedures in humans or animals. The physiological and toxicological properties of this chemical have not been fully investigated.\u003c\/p\u003e","brand":"Peptagon","offers":[{"title":"50mg","offer_id":47710044618966,"sku":"GHKCU-50","price":29.0,"currency_code":"USD","in_stock":true},{"title":"75mg","offer_id":47710044651734,"sku":"GHKCU-75-6ML","price":37.0,"currency_code":"USD","in_stock":true},{"title":"100mg","offer_id":47710044684502,"sku":"GHKCU-100-6ML","price":44.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0783\/3085\/5638\/files\/Front_Back-GHK-Cu50mg.png?v=1779128552"},{"product_id":"ghrp-6-ghs-r1a-research-peptide","title":"GHRP-6 Research Peptide – 5mg","description":"\u003ch4 data-path-to-node=\"13\"\u003e\u003cstrong\u003eGHRP-6 Peptide (Lyophilized)\u003c\/strong\u003e\u003c\/h4\u003e\n\u003cp data-path-to-node=\"14\"\u003e\u003cb data-path-to-node=\"14\" data-index-in-node=\"0\"\u003eSequence:\u003c\/b\u003e His-D-Trp-Ala-Trp-D-Phe-Lys-NH2 \u003cb data-path-to-node=\"14\" data-index-in-node=\"42\"\u003eFormat:\u003c\/b\u003e Sterile Lyophilized Powder (Vial) \u003cb data-path-to-node=\"14\" data-index-in-node=\"84\"\u003eClass:\u003c\/b\u003e Growth Hormone Secretagogue (GHS) \u003cb data-path-to-node=\"14\" data-index-in-node=\"125\"\u003ePurity:\u003c\/b\u003e \u0026gt;98% (HPLC) \u003cb data-path-to-node=\"14\" data-index-in-node=\"145\"\u003eContent:\u003c\/b\u003e 5mg per vial\u003c\/p\u003e\n\u003chr data-path-to-node=\"15\"\u003e\n\u003ch3 data-path-to-node=\"16\"\u003e\u003cb data-path-to-node=\"16\" data-index-in-node=\"0\"\u003eProduct Overview\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp data-path-to-node=\"17\"\u003e\u003cb data-path-to-node=\"17\" data-index-in-node=\"0\"\u003eGHRP-6\u003c\/b\u003e is a synthetic hexapeptide and the first true Growth Hormone Secretagogue (GHS) developed. It acts as a potent agonist of the \u003cb data-path-to-node=\"17\" data-index-in-node=\"133\"\u003eGhrelin Receptor (GHS-R1a)\u003c\/b\u003e, mimicking the hunger hormone ghrelin to stimulate the release of Growth Hormone (GH) from the pituitary gland.\u003c\/p\u003e\n\u003cp data-path-to-node=\"18\"\u003eUnlike newer, selective secretagogues (like Ipamorelin), GHRP-6 retains a broad pharmacological profile. It is renowned for its intense \u003cb data-path-to-node=\"18\" data-index-in-node=\"136\"\u003eorexigenic (appetite-stimulating)\u003c\/b\u003e effects and its secondary action on the \u003cb data-path-to-node=\"18\" data-index-in-node=\"210\"\u003eCD36 receptor\u003c\/b\u003e, which confers significant cytoprotective and anti-inflammatory properties in cardiac and gastric tissues.\u003c\/p\u003e\n\u003chr data-path-to-node=\"19\"\u003e\n\u003ch3 data-path-to-node=\"20\"\u003e\u003cb data-path-to-node=\"20\" data-index-in-node=\"0\"\u003eMechanism of Action: The Dual-Pathway Agonist\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp data-path-to-node=\"21\"\u003eGHRP-6 operates via distinct receptor interactions that drive both hormonal and survival signaling.\u003c\/p\u003e\n\u003cul data-path-to-node=\"22\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"22,0,0\"\u003e\u003cb data-path-to-node=\"22,0,0\" data-index-in-node=\"0\"\u003eGHS-R1a Activation (GH Release):\u003c\/b\u003e Binds to receptors in the pituitary and hypothalamus, triggering the PLC-IP3 pathway. This causes a massive influx of calcium that releases stored Growth Hormone vesicles.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"22,1,0\"\u003e\u003cb data-path-to-node=\"22,1,0\" data-index-in-node=\"0\"\u003eCD36 Interaction (Cytoprotection):\u003c\/b\u003e Binds to the CD36 scavenger receptor on heart and endothelial cells. This activates the \u003cb data-path-to-node=\"22,1,0\" data-index-in-node=\"123\"\u003ePI3K\/Akt pathway\u003c\/b\u003e, increasing the Bcl-2\/Bax ratio to prevent apoptosis (cell death) during ischemic stress.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"22,2,0\"\u003e\u003cb data-path-to-node=\"22,2,0\" data-index-in-node=\"0\"\u003eHypothalamic Signaling:\u003c\/b\u003e Activates \u003cb data-path-to-node=\"22,2,0\" data-index-in-node=\"34\"\u003eNPY\/AgRP neurons\u003c\/b\u003e in the arcuate nucleus, driving a powerful hunger signal and metabolic shift toward anabolism.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003chr data-path-to-node=\"23\"\u003e\n\u003ch3 data-path-to-node=\"24\"\u003e\u003cb data-path-to-node=\"24\" data-index-in-node=\"0\"\u003eKey Research Applications\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp data-path-to-node=\"25\"\u003e\u003cb data-path-to-node=\"25\" data-index-in-node=\"0\"\u003e1. Potent GH Secretion \u0026amp; Diagnostics\u003c\/b\u003e GHRP-6 is one of the most powerful GH releasers available.\u003c\/p\u003e\n\u003cul data-path-to-node=\"26\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"26,0,0\"\u003e\u003cb data-path-to-node=\"26,0,0\" data-index-in-node=\"0\"\u003eDiagnostic Standard:\u003c\/b\u003e The combination of GHRH + GHRP-6 is the \"Gold Standard\" provocation test for diagnosing Adult GH Deficiency, capable of stimulating GH release even when other agents fail.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"26,1,0\"\u003e\u003cb data-path-to-node=\"26,1,0\" data-index-in-node=\"0\"\u003eSynergy:\u003c\/b\u003e Exhibits massive synergy when stacked with GHRH analogs (like CJC-1295), creating a GH pulse far greater than the sum of individual administrations.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp data-path-to-node=\"27\"\u003e\u003cb data-path-to-node=\"27\" data-index-in-node=\"0\"\u003e2. Appetite \u0026amp; Cachexia\u003c\/b\u003e Investigated for treating wasting conditions (cachexia).\u003c\/p\u003e\n\u003cul data-path-to-node=\"28\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"28,0,0\"\u003e\u003cb data-path-to-node=\"28,0,0\" data-index-in-node=\"0\"\u003eHyperphagia:\u003c\/b\u003e Induces rapid, intense hunger by mimicking ghrelin, making it a primary tool for reversing involuntary weight loss and anorexia in disease models.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp data-path-to-node=\"29\"\u003e\u003cb data-path-to-node=\"29\" data-index-in-node=\"0\"\u003e3. Cardioprotection \u0026amp; Tissue Repair\u003c\/b\u003e\u003c\/p\u003e\n\u003cul data-path-to-node=\"30\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"30,0,0\"\u003e\u003cb data-path-to-node=\"30,0,0\" data-index-in-node=\"0\"\u003eIschemia Reperfusion:\u003c\/b\u003e Reduces heart tissue damage following heart attacks by preventing mitochondrial collapse via the CD36 pathway.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"30,1,0\"\u003e\u003cb data-path-to-node=\"30,1,0\" data-index-in-node=\"0\"\u003eGastric Protection:\u003c\/b\u003e Acts as a potent cytoprotectant in the stomach, preventing stress ulcers and accelerating gastric emptying (prokinetic effect) in models of diabetic gastroparesis.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003chr data-path-to-node=\"31\"\u003e\n\u003ch3 data-path-to-node=\"32\"\u003e\u003cb data-path-to-node=\"32\" data-index-in-node=\"0\"\u003eStorage \u0026amp; Handling\u003c\/b\u003e\u003c\/h3\u003e\n\u003cul data-path-to-node=\"33\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"33,0,0\"\u003e\u003cb data-path-to-node=\"33,0,0\" data-index-in-node=\"0\"\u003ePhysical State:\u003c\/b\u003e Lyophilized (Freeze-Dried) White Powder.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"33,1,0\"\u003e\u003cb data-path-to-node=\"33,1,0\" data-index-in-node=\"0\"\u003eStorage (Powder):\u003c\/b\u003e Store at -20°C (Freezer). Stable for up to 36 months.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"33,2,0\"\u003e\u003cb data-path-to-node=\"33,2,0\" data-index-in-node=\"0\"\u003eReconstitution:\u003c\/b\u003e\u003c\/p\u003e\n\u003cul data-path-to-node=\"33,2,1\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"33,2,1,0,0\"\u003e\u003cb data-path-to-node=\"33,2,1,0,0\" data-index-in-node=\"0\"\u003eSolvent:\u003c\/b\u003e Bacteriostatic Water or Sterile Saline.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"33,2,1,1,0\"\u003e\u003cb data-path-to-node=\"33,2,1,1,0\" data-index-in-node=\"0\"\u003eSolubility:\u003c\/b\u003e Highly soluble due to cationic residues.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"33,3,0\"\u003e\u003cb data-path-to-node=\"33,3,0\" data-index-in-node=\"0\"\u003eStorage (Liquid):\u003c\/b\u003e Store at 4°C (Refrigerator). Use within 3-4 weeks.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003chr data-path-to-node=\"34\"\u003e\n\u003ch3 data-path-to-node=\"35\"\u003e\u003cb data-path-to-node=\"35\" data-index-in-node=\"0\"\u003eDisclaimer\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp data-path-to-node=\"36\"\u003e\u003cb data-path-to-node=\"36\" data-index-in-node=\"0\"\u003eFOR RESEARCH USE ONLY.\u003c\/b\u003e This product is a chemical compound intended strictly for laboratory research and development. It is not approved by the FDA for clinical use, diagnostics, or therapeutic procedures in humans or animals. The physiological and toxicological properties of this chemical have not been fully investigated.\u003c\/p\u003e","brand":"Peptagon","offers":[{"title":"Default Title","offer_id":47710089085142,"sku":"GHRP6-5","price":29.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0783\/3085\/5638\/files\/GHRP-6-5mg.png?v=1768509420"},{"product_id":"ghrp-2-pralmorelin-research-peptide","title":"GHRP-2 Research Peptide – 5mg \/ 10mg","description":"\u003ch4 data-path-to-node=\"13\"\u003e\u003cstrong\u003eGHRP-2 Peptide (Lyophilized)\u003c\/strong\u003e\u003c\/h4\u003e\n\u003cp data-path-to-node=\"14\"\u003e\u003cb data-path-to-node=\"14\" data-index-in-node=\"0\"\u003eSequence:\u003c\/b\u003e D-Ala-D-2-Nal-Ala-Trp-D-Phe-Lys-NH2 \u003cb data-path-to-node=\"14\" data-index-in-node=\"46\"\u003eFormat:\u003c\/b\u003e Sterile Lyophilized Powder (Vial) \u003cb data-path-to-node=\"14\" data-index-in-node=\"88\"\u003eClass:\u003c\/b\u003e Growth Hormone Secretagogue (GHS) \u003cb data-path-to-node=\"14\" data-index-in-node=\"129\"\u003ePurity:\u003c\/b\u003e \u0026gt;98% (HPLC) \u003cb data-path-to-node=\"14\" data-index-in-node=\"149\"\u003eContent:\u003c\/b\u003e Available in 5mg and 10mg vials\u003c\/p\u003e\n\u003chr data-path-to-node=\"15\"\u003e\n\u003ch3 data-path-to-node=\"16\"\u003e\u003cb data-path-to-node=\"16\" data-index-in-node=\"0\"\u003eProduct Overview\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp data-path-to-node=\"17\"\u003e\u003cb data-path-to-node=\"17\" data-index-in-node=\"0\"\u003eGHRP-2 (Pralmorelin)\u003c\/b\u003e is a synthetic hexapeptide and a \"super-analog\" of GHRP-6. It is one of the most potent Growth Hormone Secretagogues (GHS) available, with an \u003cb data-path-to-node=\"17\" data-index-in-node=\"163\"\u003eED50 of 0.6 nmol\/kg\u003c\/b\u003e (significantly more potent than GHRP-6 or Ipamorelin).\u003c\/p\u003e\n\u003cp data-path-to-node=\"18\"\u003eUnlike selective agonists, GHRP-2 retains a promiscuous receptor profile similar to the endogenous hormone ghrelin. This results in broad physiological effects, including potent GH release, significant stimulation of the \u003cb data-path-to-node=\"18\" data-index-in-node=\"221\"\u003eHPA axis (Cortisol\/ACTH)\u003c\/b\u003e, and appetite stimulation. It is a critical reagent for researching conditions of growth failure, catabolic wasting, and hypothalamic dysfunction.\u003c\/p\u003e\n\u003chr data-path-to-node=\"19\"\u003e\n\u003ch3 data-path-to-node=\"20\"\u003e\u003cb data-path-to-node=\"20\" data-index-in-node=\"0\"\u003eMechanism of Action: Multi-Axis Stimulation\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp data-path-to-node=\"21\"\u003eGHRP-2 operates via the \u003cb data-path-to-node=\"21\" data-index-in-node=\"24\"\u003ePLC-IP3-Calcium\u003c\/b\u003e pathway, distinct from GHRH's cAMP pathway.\u003c\/p\u003e\n\u003cul data-path-to-node=\"22\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"22,0,0\"\u003e\u003cb data-path-to-node=\"22,0,0\" data-index-in-node=\"0\"\u003eGHS-R1a Activation:\u003c\/b\u003e Binds with high affinity to receptors in the pituitary and hypothalamus, triggering massive calcium influx and GH exocytosis.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"22,1,0\"\u003e\u003cb data-path-to-node=\"22,1,0\" data-index-in-node=\"0\"\u003eHPA Axis Stimulation:\u003c\/b\u003e uniquely stimulates the release of \u003cb data-path-to-node=\"22,1,0\" data-index-in-node=\"57\"\u003eACTH\u003c\/b\u003e and \u003cb data-path-to-node=\"22,1,0\" data-index-in-node=\"66\"\u003eCortisol\u003c\/b\u003e, making it a valuable probe for adrenal insufficiency (GHRP-2 Test).\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"22,2,0\"\u003e\u003cb data-path-to-node=\"22,2,0\" data-index-in-node=\"0\"\u003eSynergy:\u003c\/b\u003e When co-administered with GHRH, it produces a \u003cb data-path-to-node=\"22,2,0\" data-index-in-node=\"55\"\u003e54-fold increase\u003c\/b\u003e in GH secretion, far exceeding the sum of individual administrations.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"22,3,0\"\u003e\u003cb data-path-to-node=\"22,3,0\" data-index-in-node=\"0\"\u003eCD36 Interaction:\u003c\/b\u003e Activates the CD36 scavenger receptor, providing cardioprotection against ischemia-reperfusion injury via the RISK and SAFE kinase pathways.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003chr data-path-to-node=\"23\"\u003e\n\u003ch3 data-path-to-node=\"24\"\u003e\u003cb data-path-to-node=\"24\" data-index-in-node=\"0\"\u003eKey Research Applications\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp data-path-to-node=\"25\"\u003e\u003cb data-path-to-node=\"25\" data-index-in-node=\"0\"\u003e1. Endocrine Diagnostics \u0026amp; Growth\u003c\/b\u003e GHRP-2 is the benchmark for provoking maximal GH release.\u003c\/p\u003e\n\u003cul data-path-to-node=\"26\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"26,0,0\"\u003e\u003cb data-path-to-node=\"26,0,0\" data-index-in-node=\"0\"\u003eDiagnostic Utility:\u003c\/b\u003e Investigated as a single-agent test for both GH and ACTH deficiency, offering high specificity (100%) and sensitivity.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"26,1,0\"\u003e\u003cb data-path-to-node=\"26,1,0\" data-index-in-node=\"0\"\u003eGrowth Rescue:\u003c\/b\u003e In genetic models (like \u003ci data-path-to-node=\"26,1,0\" data-index-in-node=\"39\"\u003elit\/lit\u003c\/i\u003e mice), it stimulates growth even in the absence of functional GHRH receptors.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp data-path-to-node=\"27\"\u003e\u003cb data-path-to-node=\"27\" data-index-in-node=\"0\"\u003e2. Catabolism \u0026amp; Appetite\u003c\/b\u003e\u003c\/p\u003e\n\u003cul data-path-to-node=\"28\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"28,0,0\"\u003e\u003cb data-path-to-node=\"28,0,0\" data-index-in-node=\"0\"\u003eOrexigenic Effect:\u003c\/b\u003e Increases food intake by ~36% in human trials by activating NPY\/AgRP neurons in the hypothalamus.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"28,1,0\"\u003e\u003cb data-path-to-node=\"28,1,0\" data-index-in-node=\"0\"\u003eAnti-Catabolic:\u003c\/b\u003e Prevents muscle wasting in inflammatory states (e.g., arthritis) by downregulating the ubiquitin ligases \u003cb data-path-to-node=\"28,1,0\" data-index-in-node=\"121\"\u003eMuRF1\u003c\/b\u003e and \u003cb data-path-to-node=\"28,1,0\" data-index-in-node=\"131\"\u003eMAFbx\u003c\/b\u003e.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp data-path-to-node=\"29\"\u003e\u003cb data-path-to-node=\"29\" data-index-in-node=\"0\"\u003e3. Cardioprotection\u003c\/b\u003e\u003c\/p\u003e\n\u003cul data-path-to-node=\"30\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"30,0,0\"\u003e\u003cb data-path-to-node=\"30,0,0\" data-index-in-node=\"0\"\u003eStunning Recovery:\u003c\/b\u003e Pretreatment with GHRP-2 fully protects heart muscle from diastolic dysfunction (stunning) following ischemia.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"30,1,0\"\u003e\u003cb data-path-to-node=\"30,1,0\" data-index-in-node=\"0\"\u003eInfarct Reduction:\u003c\/b\u003e Research indicates it reduces myocardial infarct size by preventing mitochondrial permeability transition pore (mPTP) opening.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003chr data-path-to-node=\"31\"\u003e\n\u003ch3 data-path-to-node=\"32\"\u003e\u003cb data-path-to-node=\"32\" data-index-in-node=\"0\"\u003eStorage \u0026amp; Handling\u003c\/b\u003e\u003c\/h3\u003e\n\u003cul data-path-to-node=\"33\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"33,0,0\"\u003e\u003cb data-path-to-node=\"33,0,0\" data-index-in-node=\"0\"\u003ePhysical State:\u003c\/b\u003e Lyophilized (Freeze-Dried) White Powder.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"33,1,0\"\u003e\u003cb data-path-to-node=\"33,1,0\" data-index-in-node=\"0\"\u003eStorage (Powder):\u003c\/b\u003e Store at -20°C (Freezer). Stable for up to 24 months.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"33,2,0\"\u003e\u003cb data-path-to-node=\"33,2,0\" data-index-in-node=\"0\"\u003eReconstitution:\u003c\/b\u003e\u003c\/p\u003e\n\u003cul data-path-to-node=\"33,2,1\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"33,2,1,0,0\"\u003e\u003cb data-path-to-node=\"33,2,1,0,0\" data-index-in-node=\"0\"\u003eSolvent:\u003c\/b\u003e Bacteriostatic Water or Sterile Saline.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"33,2,1,1,0\"\u003e\u003cb data-path-to-node=\"33,2,1,1,0\" data-index-in-node=\"0\"\u003eSolubility:\u003c\/b\u003e Highly soluble.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"33,3,0\"\u003e\u003cb data-path-to-node=\"33,3,0\" data-index-in-node=\"0\"\u003eStorage (Liquid):\u003c\/b\u003e Store at 4°C (Refrigerator). Use within 7 days to prevent oxidation of the Tryptophan residue. \u003cb data-path-to-node=\"33,3,0\" data-index-in-node=\"113\"\u003eAvoid freeze-thaw cycles.\u003c\/b\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003chr data-path-to-node=\"34\"\u003e\n\u003ch3 data-path-to-node=\"35\"\u003e\u003cb data-path-to-node=\"35\" data-index-in-node=\"0\"\u003eDisclaimer\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp data-path-to-node=\"36\"\u003e\u003cb data-path-to-node=\"36\" data-index-in-node=\"0\"\u003eFOR RESEARCH USE ONLY.\u003c\/b\u003e This product is a chemical compound intended strictly for laboratory research and development. It is not approved by the FDA for clinical use, diagnostics, or therapeutic procedures in humans or animals. The physiological and toxicological properties of this chemical have not been fully investigated.\u003c\/p\u003e","brand":"Peptagon","offers":[{"title":"5mg","offer_id":47710089445590,"sku":"GHRP2-5","price":29.0,"currency_code":"USD","in_stock":true},{"title":"10mg","offer_id":47710089478358,"sku":"GHRP2-10","price":36.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0783\/3085\/5638\/files\/GHRP-2-5mg.png?v=1768509327"},{"product_id":"gonadorelin-acetate-gnrh-research-peptide","title":"Gonadorelin Research Peptide – 5mg \/ 10mg","description":"\u003ch4 data-path-to-node=\"13\"\u003e\u003cstrong\u003eGonadorelin (GnRH) Peptide (Lyophilized)\u003c\/strong\u003e\u003c\/h4\u003e\n\u003cp data-path-to-node=\"14\"\u003e\u003cb data-path-to-node=\"14\" data-index-in-node=\"0\"\u003eSequence:\u003c\/b\u003e pGlu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH2 \u003cb data-path-to-node=\"14\" data-index-in-node=\"55\"\u003eFormat:\u003c\/b\u003e Sterile Lyophilized Powder (Vial) \u003cb data-path-to-node=\"14\" data-index-in-node=\"97\"\u003eClass:\u003c\/b\u003e Gonadotropin-Releasing Hormone Agonist \u003cb data-path-to-node=\"14\" data-index-in-node=\"143\"\u003ePurity:\u003c\/b\u003e \u0026gt;98% (HPLC) \u003cb data-path-to-node=\"14\" data-index-in-node=\"163\"\u003eContent:\u003c\/b\u003e Available in 5mg and 10mg vials\u003c\/p\u003e\n\u003chr data-path-to-node=\"15\"\u003e\n\u003ch3 data-path-to-node=\"16\"\u003e\u003cb data-path-to-node=\"16\" data-index-in-node=\"0\"\u003eProduct Overview\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp data-path-to-node=\"17\"\u003e\u003cb data-path-to-node=\"17\" data-index-in-node=\"0\"\u003eGonadorelin\u003c\/b\u003e is the synthetic acetate salt of the endogenous decapeptide Gonadotropin-Releasing Hormone (GnRH). It serves as the primary neural integrator of the hypothalamic-pituitary-gonadal (HPG) axis.\u003c\/p\u003e\n\u003cp data-path-to-node=\"18\"\u003eThis peptide functions as a \"pulse decoder.\" The frequency and amplitude of Gonadorelin pulses determine the differential secretion of \u003cb data-path-to-node=\"18\" data-index-in-node=\"135\"\u003eLuteinizing Hormone (LH)\u003c\/b\u003e and \u003cb data-path-to-node=\"18\" data-index-in-node=\"164\"\u003eFollicle-Stimulating Hormone (FSH)\u003c\/b\u003e from the pituitary gland. The 5mg and 10mg high-concentration vials are specifically designed for large-scale veterinary research (herd synchronization) and high-throughput pharmacological screening.\u003c\/p\u003e\n\u003chr data-path-to-node=\"19\"\u003e\n\u003ch3 data-path-to-node=\"20\"\u003e\u003cb data-path-to-node=\"20\" data-index-in-node=\"0\"\u003eMechanism of Action: The Pulse Decoder\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp data-path-to-node=\"21\"\u003eGonadorelin binds to the \u003cb data-path-to-node=\"21\" data-index-in-node=\"25\"\u003eGnRHR\u003c\/b\u003e (G protein-coupled receptor) on pituitary gonadotrophs, activating the Gq\/11-Phospholipase C pathway.\u003c\/p\u003e\n\u003cul data-path-to-node=\"22\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"22,0,0\"\u003e\u003cb data-path-to-node=\"22,0,0\" data-index-in-node=\"0\"\u003ePulse Frequency Coding:\u003c\/b\u003e\u003c\/p\u003e\n\u003cul data-path-to-node=\"22,0,1\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"22,0,1,0,0\"\u003e\u003cb data-path-to-node=\"22,0,1,0,0\" data-index-in-node=\"0\"\u003eHigh Frequency (~30 min):\u003c\/b\u003e Activates the \u003cb data-path-to-node=\"22,0,1,0,0\" data-index-in-node=\"40\"\u003eMAPK\/EGR1\u003c\/b\u003e pathway, preferentially stimulating \u003cb data-path-to-node=\"22,0,1,0,0\" data-index-in-node=\"86\"\u003eLH\u003c\/b\u003e synthesis (essential for ovulation).\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"22,0,1,1,0\"\u003e\u003cb data-path-to-node=\"22,0,1,1,0\" data-index-in-node=\"0\"\u003eLow Frequency (~120 min):\u003c\/b\u003e Activates the \u003cb data-path-to-node=\"22,0,1,1,0\" data-index-in-node=\"40\"\u003ecAMP\/CREB\u003c\/b\u003e pathway, preferentially stimulating \u003cb data-path-to-node=\"22,0,1,1,0\" data-index-in-node=\"86\"\u003eFSH\u003c\/b\u003e synthesis (essential for follicular growth).\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"22,1,0\"\u003e\u003cb data-path-to-node=\"22,1,0\" data-index-in-node=\"0\"\u003eCalcium Mobilization:\u003c\/b\u003e Triggers a massive influx of intracellular calcium via IP3, driving the exocytosis of stored gonadotropins.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003chr data-path-to-node=\"23\"\u003e\n\u003ch3 data-path-to-node=\"24\"\u003e\u003cb data-path-to-node=\"24\" data-index-in-node=\"0\"\u003eKey Research Applications\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp data-path-to-node=\"25\"\u003e\u003cb data-path-to-node=\"25\" data-index-in-node=\"0\"\u003e1. Veterinary \u0026amp; Herd Management (Ovsynch)\u003c\/b\u003e In dairy and livestock research, Gonadorelin is the cornerstone of estrus synchronization protocols.\u003c\/p\u003e\n\u003cul data-path-to-node=\"26\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"26,0,0\"\u003e\u003cb data-path-to-node=\"26,0,0\" data-index-in-node=\"0\"\u003eCystic Ovaries:\u003c\/b\u003e High-dose bolus administration induces the LH surge required to luteinize follicular cysts.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"26,1,0\"\u003e\u003cb data-path-to-node=\"26,1,0\" data-index-in-node=\"0\"\u003eFTAI:\u003c\/b\u003e Used in \"Ovsynch\" protocols to synchronize ovulation across a herd, allowing for Fixed-Time Artificial Insemination without the need for estrus detection.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp data-path-to-node=\"27\"\u003e\u003cb data-path-to-node=\"27\" data-index-in-node=\"0\"\u003e2. Endocrine Diagnostics\u003c\/b\u003e Used as a diagnostic probe to assess pituitary function. The \u003cb data-path-to-node=\"27\" data-index-in-node=\"86\"\u003eGonadorelin Stimulation Test\u003c\/b\u003e differentiates between hypothalamic dysfunction (where the pituitary is intact but lacks signal) and pituitary failure.\u003c\/p\u003e\n\u003cp data-path-to-node=\"28\"\u003e\u003cb data-path-to-node=\"28\" data-index-in-node=\"0\"\u003e3. Reproductive Physiology\u003c\/b\u003e Investigated for its ability to restore pulsatile secretion in conditions like Hypothalamic Amenorrhea or Kallmann Syndrome, bypassing the need for exogenous gonadotropins.\u003c\/p\u003e\n\u003chr data-path-to-node=\"29\"\u003e\n\u003ch3 data-path-to-node=\"30\"\u003e\u003cb data-path-to-node=\"30\" data-index-in-node=\"0\"\u003eComparison: Gonadorelin vs. CJC-1295\u003c\/b\u003e\u003c\/h3\u003e\n\u003cul data-path-to-node=\"31\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"31,0,0\"\u003e\u003cb data-path-to-node=\"31,0,0\" data-index-in-node=\"0\"\u003eGonadorelin:\u003c\/b\u003e Native decapeptide. Half-life of \u003cb data-path-to-node=\"31,0,0\" data-index-in-node=\"46\"\u003e2-4 minutes\u003c\/b\u003e. Used for \u003cb data-path-to-node=\"31,0,0\" data-index-in-node=\"68\"\u003epulsatile\u003c\/b\u003e stimulation of the reproductive axis (LH\/FSH).\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"31,1,0\"\u003e\u003cb data-path-to-node=\"31,1,0\" data-index-in-node=\"0\"\u003eCJC-1295 (DAC):\u003c\/b\u003e Modified GHRH analog. Half-life of \u003cb data-path-to-node=\"31,1,0\" data-index-in-node=\"51\"\u003e6-8 days\u003c\/b\u003e. Used for \u003cb data-path-to-node=\"31,1,0\" data-index-in-node=\"70\"\u003esustained\u003c\/b\u003e stimulation of the somatotropic axis (GH\/IGF-1).\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003chr data-path-to-node=\"32\"\u003e\n\u003ch3 data-path-to-node=\"33\"\u003e\u003cb data-path-to-node=\"33\" data-index-in-node=\"0\"\u003eStorage \u0026amp; Handling\u003c\/b\u003e\u003c\/h3\u003e\n\u003cul data-path-to-node=\"34\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"34,0,0\"\u003e\u003cb data-path-to-node=\"34,0,0\" data-index-in-node=\"0\"\u003ePhysical State:\u003c\/b\u003e Lyophilized (Freeze-Dried) White Powder.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"34,1,0\"\u003e\u003cb data-path-to-node=\"34,1,0\" data-index-in-node=\"0\"\u003eStorage (Powder):\u003c\/b\u003e Store at -20°C (Freezer). Stable for up to 24 months.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"34,2,0\"\u003e\u003cb data-path-to-node=\"34,2,0\" data-index-in-node=\"0\"\u003eReconstitution:\u003c\/b\u003e\u003c\/p\u003e\n\u003cul data-path-to-node=\"34,2,1\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"34,2,1,0,0\"\u003e\u003cb data-path-to-node=\"34,2,1,0,0\" data-index-in-node=\"0\"\u003eSolvent:\u003c\/b\u003e Bacteriostatic Water or Sterile Saline.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"34,2,1,1,0\"\u003e\u003cb data-path-to-node=\"34,2,1,1,0\" data-index-in-node=\"0\"\u003eSolubility:\u003c\/b\u003e Highly soluble in water.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"34,3,0\"\u003e\u003cb data-path-to-node=\"34,3,0\" data-index-in-node=\"0\"\u003eStorage (Liquid):\u003c\/b\u003e Store at 4°C (Refrigerator). Use within 7 days. For herd-level stock solutions, aliquot and freeze to prevent degradation.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003chr data-path-to-node=\"35\"\u003e\n\u003ch3 data-path-to-node=\"36\"\u003e\u003cb data-path-to-node=\"36\" data-index-in-node=\"0\"\u003eDisclaimer\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp data-path-to-node=\"37\"\u003e\u003cb data-path-to-node=\"37\" data-index-in-node=\"0\"\u003eFOR RESEARCH USE ONLY.\u003c\/b\u003e This product is a chemical compound intended strictly for laboratory research and development. It is not approved by the FDA for clinical use, diagnostics, or therapeutic procedures in humans or animals. The physiological and toxicological properties of this chemical have not been fully investigated.\u003c\/p\u003e","brand":"Peptagon","offers":[{"title":"5mg","offer_id":47710109860054,"sku":"GONAD-5","price":29.0,"currency_code":"USD","in_stock":true},{"title":"10mg","offer_id":47710109892822,"sku":"GONAD-10","price":36.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0783\/3085\/5638\/files\/Gonadorelin-10mg.png?v=1768510871"},{"product_id":"hexarelin-acetate-ghs-r1a-research-peptide","title":"Hexarelin Acetate Research Peptide – 5mg","description":"\u003ch4 data-path-to-node=\"13\"\u003e\u003cstrong\u003eHexarelin Acetate Peptide (Lyophilized)\u003c\/strong\u003e\u003c\/h4\u003e\n\u003cp data-path-to-node=\"14\"\u003e\u003cb data-path-to-node=\"14\" data-index-in-node=\"0\"\u003eSequence:\u003c\/b\u003e His-D-2-MeTrp-Ala-Trp-D-Phe-Lys-NH2 \u003cb data-path-to-node=\"14\" data-index-in-node=\"46\"\u003eFormat:\u003c\/b\u003e Sterile Lyophilized Powder (Vial) \u003cb data-path-to-node=\"14\" data-index-in-node=\"88\"\u003eClass:\u003c\/b\u003e Growth Hormone Secretagogue (GHS) \u003cb data-path-to-node=\"14\" data-index-in-node=\"129\"\u003ePurity:\u003c\/b\u003e \u0026gt;99% (HPLC) \u003cb data-path-to-node=\"14\" data-index-in-node=\"149\"\u003eContent:\u003c\/b\u003e 5mg per vial\u003c\/p\u003e\n\u003chr data-path-to-node=\"15\"\u003e\n\u003ch3 data-path-to-node=\"16\"\u003e\u003cb data-path-to-node=\"16\" data-index-in-node=\"0\"\u003eProduct Overview\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp data-path-to-node=\"17\"\u003e\u003cb data-path-to-node=\"17\" data-index-in-node=\"0\"\u003eHexarelin\u003c\/b\u003e is a synthetic hexapeptide and a \"super-agonist\" of the Growth Hormone Secretagogue Receptor (GHS-R1a). It is chemically modified with D-amino acids (D-2-Methyl-Trp, D-Phe) to resist enzymatic degradation, giving it a prolonged half-life and potency superior to native ghrelin.\u003c\/p\u003e\n\u003cp data-path-to-node=\"18\"\u003eUnlike selective secretagogues, Hexarelin exhibits a unique dual-receptor pharmacology. It activates both the \u003cb data-path-to-node=\"18\" data-index-in-node=\"110\"\u003eGHS-R1a\u003c\/b\u003e (endocrine axis) and the \u003cb data-path-to-node=\"18\" data-index-in-node=\"143\"\u003eCD36 Scavenger Receptor\u003c\/b\u003e (cardiovascular\/metabolic axis). This pleiotropic profile makes it a critical reagent for researching cardiac ischemia, neuroprotection, and metabolic regulation.\u003c\/p\u003e\n\u003chr data-path-to-node=\"19\"\u003e\n\u003ch3 data-path-to-node=\"20\"\u003e\u003cb data-path-to-node=\"20\" data-index-in-node=\"0\"\u003eMechanism of Action: The Dual-Receptor Agonist\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp data-path-to-node=\"21\"\u003eHexarelin operates via two distinct signaling pathways:\u003c\/p\u003e\n\u003cul data-path-to-node=\"22\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"22,0,0\"\u003e\u003cb data-path-to-node=\"22,0,0\" data-index-in-node=\"0\"\u003eGHS-R1a Activation (Endocrine):\u003c\/b\u003e Binds to pituitary receptors with high affinity, triggering the PLC-IP3 pathway and massive calcium influx. This releases a \"reserve pool\" of Growth Hormone vesicles, creating a pulse larger than GHRH alone.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"22,1,0\"\u003e\u003cb data-path-to-node=\"22,1,0\" data-index-in-node=\"0\"\u003eCD36 Interaction (Cardio-Metabolic):\u003c\/b\u003e Binds to the CD36 receptor on heart and immune cells. This activates \u003cb data-path-to-node=\"22,1,0\" data-index-in-node=\"106\"\u003ePPAR-gamma\u003c\/b\u003e and the \u003cb data-path-to-node=\"22,1,0\" data-index-in-node=\"125\"\u003ePI3K\/Akt pathway\u003c\/b\u003e, promoting cell survival, mitochondrial biogenesis, and cholesterol efflux from macrophages.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003chr data-path-to-node=\"23\"\u003e\n\u003ch3 data-path-to-node=\"24\"\u003e\u003cb data-path-to-node=\"24\" data-index-in-node=\"0\"\u003eKey Research Applications\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp data-path-to-node=\"25\"\u003e\u003cb data-path-to-node=\"25\" data-index-in-node=\"0\"\u003e1. Potent GH Secretion\u003c\/b\u003e Hexarelin is one of the most powerful GH releasers known.\u003c\/p\u003e\n\u003cul data-path-to-node=\"26\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"26,0,0\"\u003e\u003cb data-path-to-node=\"26,0,0\" data-index-in-node=\"0\"\u003eSuper-Agonist:\u003c\/b\u003e Capable of stimulating GH release even in models of somatostatin inhibition.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"26,1,0\"\u003e\u003cb data-path-to-node=\"26,1,0\" data-index-in-node=\"0\"\u003eMetabolic Rescue:\u003c\/b\u003e In diabetic models, it restores GH pulsatility (though IGF-1 response depends on insulin status).\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp data-path-to-node=\"27\"\u003e\u003cb data-path-to-node=\"27\" data-index-in-node=\"0\"\u003e2. Cardioprotection \u0026amp; Ischemia\u003c\/b\u003e\u003c\/p\u003e\n\u003cul data-path-to-node=\"28\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"28,0,0\"\u003e\u003cb data-path-to-node=\"28,0,0\" data-index-in-node=\"0\"\u003eInotropy:\u003c\/b\u003e Increases cardiac contractility (squeeze) without significantly raising heart rate, improving ejection fraction in ischemic models.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"28,1,0\"\u003e\u003cb data-path-to-node=\"28,1,0\" data-index-in-node=\"0\"\u003eInfarct Reduction:\u003c\/b\u003e Pretreatment significantly reduces the size of necrotic tissue following heart attacks (ischemia-reperfusion injury).\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp data-path-to-node=\"29\"\u003e\u003cb data-path-to-node=\"29\" data-index-in-node=\"0\"\u003e3. Neuroprotection\u003c\/b\u003e\u003c\/p\u003e\n\u003cul data-path-to-node=\"30\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"30,0,0\"\u003e\u003cb data-path-to-node=\"30,0,0\" data-index-in-node=\"0\"\u003eSurvival Kinases:\u003c\/b\u003e Protects neurons from oxidative stress and toxicity (e.g., chemotherapy) by activating the PI3K\/Akt survival pathway and inhibiting caspase-3 (apoptosis).\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp data-path-to-node=\"31\"\u003e\u003cb data-path-to-node=\"31\" data-index-in-node=\"0\"\u003e4. Metabolic Regulation\u003c\/b\u003e\u003c\/p\u003e\n\u003cul data-path-to-node=\"32\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"32,0,0\"\u003e\u003cb data-path-to-node=\"32,0,0\" data-index-in-node=\"0\"\u003eLipid Metabolism:\u003c\/b\u003e Promotes the clearance of triglycerides and cholesterol via CD36\/PPAR-gamma signaling in the liver and macrophages.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003chr data-path-to-node=\"33\"\u003e\n\u003ch3 data-path-to-node=\"34\"\u003e\u003cb data-path-to-node=\"34\" data-index-in-node=\"0\"\u003eStorage \u0026amp; Handling\u003c\/b\u003e\u003c\/h3\u003e\n\u003cul data-path-to-node=\"35\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"35,0,0\"\u003e\u003cb data-path-to-node=\"35,0,0\" data-index-in-node=\"0\"\u003ePhysical State:\u003c\/b\u003e Lyophilized (Freeze-Dried) White Powder.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"35,1,0\"\u003e\u003cb data-path-to-node=\"35,1,0\" data-index-in-node=\"0\"\u003eStorage (Powder):\u003c\/b\u003e Store at -20°C (Freezer). Stable for up to 36 months.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"35,2,0\"\u003e\u003cb data-path-to-node=\"35,2,0\" data-index-in-node=\"0\"\u003eReconstitution:\u003c\/b\u003e\u003c\/p\u003e\n\u003cul data-path-to-node=\"35,2,1\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"35,2,1,0,0\"\u003e\u003cb data-path-to-node=\"35,2,1,0,0\" data-index-in-node=\"0\"\u003eSolvent:\u003c\/b\u003e Bacteriostatic Water or Sterile Saline.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"35,2,1,1,0\"\u003e\u003cb data-path-to-node=\"35,2,1,1,0\" data-index-in-node=\"0\"\u003eSolubility:\u003c\/b\u003e Highly soluble.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"35,3,0\"\u003e\u003cb data-path-to-node=\"35,3,0\" data-index-in-node=\"0\"\u003eStorage (Liquid):\u003c\/b\u003e Store at 4°C (Refrigerator). Use within 14-21 days. \u003cb data-path-to-node=\"35,3,0\" data-index-in-node=\"70\"\u003eAvoid freeze-thaw cycles.\u003c\/b\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003chr data-path-to-node=\"36\"\u003e\n\u003ch3 data-path-to-node=\"37\"\u003e\u003cb data-path-to-node=\"37\" data-index-in-node=\"0\"\u003eDisclaimer\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp data-path-to-node=\"38\"\u003e\u003cb data-path-to-node=\"38\" data-index-in-node=\"0\"\u003eFOR RESEARCH USE ONLY.\u003c\/b\u003e This product is a chemical compound intended strictly for laboratory research and development. It is not approved by the FDA for clinical use, diagnostics, or therapeutic procedures in humans or animals. The physiological and toxicological properties of this chemical have not been fully investigated.\u003c\/p\u003e","brand":"Peptagon","offers":[{"title":"Default Title","offer_id":47712186990806,"sku":"HEXAR-5","price":36.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0783\/3085\/5638\/files\/Hexarelin-5mg_bb7d043e-4e91-42ae-9b53-80008e2bb244.png?v=1768510031"},{"product_id":"igf-1-lr3-long-r3-igf-1-research-peptide","title":"IGF-1 LR3 Research Peptide – 1mg","description":"\u003ch4 data-path-to-node=\"13\"\u003e\u003cstrong\u003eIGF-1 LR3 Peptide (Lyophilized)\u003c\/strong\u003e\u003c\/h4\u003e\n\u003cp data-path-to-node=\"14\"\u003e\u003cb data-path-to-node=\"14\" data-index-in-node=\"0\"\u003eSequence:\u003c\/b\u003e Modified Human IGF-1 (83 Amino Acids) \u003cb data-path-to-node=\"14\" data-index-in-node=\"48\"\u003eFormat:\u003c\/b\u003e Sterile Lyophilized Powder (Vial) \u003cb data-path-to-node=\"14\" data-index-in-node=\"90\"\u003eModifications:\u003c\/b\u003e Glu3→Arg3 Substitution + 13 AA N-Terminal Extension \u003cb data-path-to-node=\"14\" data-index-in-node=\"157\"\u003ePurity:\u003c\/b\u003e \u0026gt;95% (SDS-PAGE \/ Receptor Grade) \u003cb data-path-to-node=\"14\" data-index-in-node=\"198\"\u003eContent:\u003c\/b\u003e 1mg per vial\u003c\/p\u003e\n\u003chr data-path-to-node=\"15\"\u003e\n\u003ch3 data-path-to-node=\"16\"\u003e\u003cb data-path-to-node=\"16\" data-index-in-node=\"0\"\u003eProduct Overview\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp data-path-to-node=\"17\"\u003e\u003cb data-path-to-node=\"17\" data-index-in-node=\"0\"\u003eIGF-1 LR3 (Long R3 Insulin-like Growth Factor-1)\u003c\/b\u003e is a recombinant analog of human IGF-1, engineered to overcome the pharmacokinetic limitations of the native hormone.\u003c\/p\u003e\n\u003cp data-path-to-node=\"18\"\u003eWhile native IGF-1 has a half-life of minutes and is tightly sequestered by binding proteins (IGFBPs), IGF-1 LR3 incorporates two critical modifications:\u003c\/p\u003e\n\u003col start=\"1\" data-path-to-node=\"19\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"19,0,0\"\u003e\u003cb data-path-to-node=\"19,0,0\" data-index-in-node=\"0\"\u003eArg3 Substitution:\u003c\/b\u003e Prevents binding to IGFBPs, keeping the peptide \"free\" and bioactive.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"19,1,0\"\u003e\u003cb data-path-to-node=\"19,1,0\" data-index-in-node=\"0\"\u003eN-Terminal Extension:\u003c\/b\u003e Increases metabolic stability and half-life to \u003cb data-path-to-node=\"19,1,0\" data-index-in-node=\"69\"\u003e20-30 hours\u003c\/b\u003e.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ol\u003e\n\u003cp data-path-to-node=\"20\"\u003eThis design creates a molecule that is \u003cb data-path-to-node=\"20\" data-index-in-node=\"39\"\u003e2-3 times more potent\u003c\/b\u003e than native IGF-1 in driving anabolism and nitrogen retention in research models.\u003c\/p\u003e\n\u003chr data-path-to-node=\"21\"\u003e\n\u003ch3 data-path-to-node=\"22\"\u003e\u003cb data-path-to-node=\"22\" data-index-in-node=\"0\"\u003eMechanism of Action: The Unbound Agonist\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp data-path-to-node=\"23\"\u003eIGF-1 LR3 bypasses the body's natural regulatory buffers to deliver sustained signaling.\u003c\/p\u003e\n\u003cul data-path-to-node=\"24\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"24,0,0\"\u003e\u003cb data-path-to-node=\"24,0,0\" data-index-in-node=\"0\"\u003ePI3K\/Akt\/mTOR Pathway:\u003c\/b\u003e Activates the primary engine of protein synthesis. It recruits IRS-1 and PI3K, leading to the phosphorylation of mTOR, which drives ribosomal activity and muscle hypertrophy.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"24,1,0\"\u003e\u003cb data-path-to-node=\"24,1,0\" data-index-in-node=\"0\"\u003eFoxO Suppression:\u003c\/b\u003e Phosphorylates FoxO transcription factors, trapping them in the cytoplasm. This prevents them from transcribing muscle atrophy genes (\u003cb data-path-to-node=\"24,1,0\" data-index-in-node=\"152\"\u003eAtrogin-1\u003c\/b\u003e, \u003cb data-path-to-node=\"24,1,0\" data-index-in-node=\"163\"\u003eMuRF1\u003c\/b\u003e), effectively blocking protein breakdown.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"24,2,0\"\u003e\u003cb data-path-to-node=\"24,2,0\" data-index-in-node=\"0\"\u003eGlucose Partitioning:\u003c\/b\u003e Cross-activates Insulin\/IGF-1 Hybrid Receptors on muscle cells, driving GLUT4 translocation and glucose uptake independently of insulin levels.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003chr data-path-to-node=\"25\"\u003e\n\u003ch3 data-path-to-node=\"26\"\u003e\u003cb data-path-to-node=\"26\" data-index-in-node=\"0\"\u003eKey Research Applications\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp data-path-to-node=\"27\"\u003e\u003cb data-path-to-node=\"27\" data-index-in-node=\"0\"\u003e1. Musculoskeletal Hypertrophy\u003c\/b\u003e IGF-1 LR3 is the gold standard for research into rapid muscle growth.\u003c\/p\u003e\n\u003cul data-path-to-node=\"28\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"28,0,0\"\u003e\u003cb data-path-to-node=\"28,0,0\" data-index-in-node=\"0\"\u003ePotency:\u003c\/b\u003e In nitrogen balance studies (Tomas et al.), LR3 was significantly more effective than native IGF-1 at promoting weight gain and nitrogen retention, even with once-daily dosing.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"28,1,0\"\u003e\u003cb data-path-to-node=\"28,1,0\" data-index-in-node=\"0\"\u003eDifferentiation:\u003c\/b\u003e Promotes both the proliferation of satellite cells (via MAPK) and their fusion into myotubes (via Myogenin), supporting hyperplasia and hypertrophy.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp data-path-to-node=\"29\"\u003e\u003cb data-path-to-node=\"29\" data-index-in-node=\"0\"\u003e2. Metabolic Partitioning\u003c\/b\u003e Investigated for its \"leaning\" effect.\u003c\/p\u003e\n\u003cul data-path-to-node=\"30\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"30,0,0\"\u003e\u003cb data-path-to-node=\"30,0,0\" data-index-in-node=\"0\"\u003eNutrient Shuttling:\u003c\/b\u003e Drives glucose and amino acids into muscle tissue while suppressing insulin secretion. Low insulin disinhibits lipolysis (fat breakdown), shifting the metabolic preference toward burning fat for fuel.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp data-path-to-node=\"31\"\u003e\u003cb data-path-to-node=\"31\" data-index-in-node=\"0\"\u003e3. Cell Culture \u0026amp; Bioengineering\u003c\/b\u003e Widely used in serum-free media to maintain \u003cb data-path-to-node=\"31\" data-index-in-node=\"77\"\u003estem cells (iPSCs\/hESCs)\u003c\/b\u003e. Its stability allows for less frequent media changes while maintaining pluripotency and survival better than native growth factors.\u003c\/p\u003e\n\u003chr data-path-to-node=\"32\"\u003e\n\u003ch3 data-path-to-node=\"33\"\u003e\u003cb data-path-to-node=\"33\" data-index-in-node=\"0\"\u003eStorage \u0026amp; Handling\u003c\/b\u003e\u003c\/h3\u003e\n\u003cul data-path-to-node=\"34\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"34,0,0\"\u003e\u003cb data-path-to-node=\"34,0,0\" data-index-in-node=\"0\"\u003ePhysical State:\u003c\/b\u003e Lyophilized (Freeze-Dried) Powder.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"34,1,0\"\u003e\u003cb data-path-to-node=\"34,1,0\" data-index-in-node=\"0\"\u003eStorage (Powder):\u003c\/b\u003e Store at -20°C (Freezer). Stable for up to 12 months.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"34,2,0\"\u003e\u003cb data-path-to-node=\"34,2,0\" data-index-in-node=\"0\"\u003eReconstitution:\u003c\/b\u003e\u003c\/p\u003e\n\u003cul data-path-to-node=\"34,2,1\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"34,2,1,0,0\"\u003e\u003cb data-path-to-node=\"34,2,1,0,0\" data-index-in-node=\"0\"\u003eSolvent:\u003c\/b\u003e \u003cb data-path-to-node=\"34,2,1,0,0\" data-index-in-node=\"9\"\u003e10-100mM HCl\u003c\/b\u003e or \u003cb data-path-to-node=\"34,2,1,0,0\" data-index-in-node=\"25\"\u003eAcetic Acid\u003c\/b\u003e is often recommended for the initial dissolution to prevent aggregation, followed by dilution with sterile buffer. Alternatively, use Bacteriostatic Water if using immediately.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"34,3,0\"\u003e\u003cb data-path-to-node=\"34,3,0\" data-index-in-node=\"0\"\u003eStorage (Liquid):\u003c\/b\u003e Store at 4°C. \u003cb data-path-to-node=\"34,3,0\" data-index-in-node=\"32\"\u003eVery sensitive to degradation.\u003c\/b\u003e Use within 7 days. Avoid freeze-thaw cycles.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003chr data-path-to-node=\"35\"\u003e\n\u003ch3 data-path-to-node=\"36\"\u003e\u003cb data-path-to-node=\"36\" data-index-in-node=\"0\"\u003eDisclaimer\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp data-path-to-node=\"37\"\u003e\u003cb data-path-to-node=\"37\" data-index-in-node=\"0\"\u003eFOR RESEARCH USE ONLY.\u003c\/b\u003e This product is a chemical compound intended strictly for laboratory research and development. It is not approved by the FDA for clinical use, diagnostics, or therapeutic procedures in humans or animals. The physiological and toxicological properties of this chemical have not been fully investigated.\u003c\/p\u003e","brand":"Peptagon","offers":[{"title":"Default Title","offer_id":47712189219030,"sku":"IGF1LR3-1","price":47.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0783\/3085\/5638\/files\/IGF-1LR3-1mg.png?v=1768509272"},{"product_id":"ipamorelin-ghs-r1a-research-peptide","title":"Ipamorelin Research Peptide – 10mg","description":"\u003ch4 data-path-to-node=\"13\"\u003e\u003cstrong\u003eIpamorelin Peptide (Lyophilized)\u003c\/strong\u003e\u003c\/h4\u003e\n\u003cp data-path-to-node=\"14\"\u003e\u003cb data-path-to-node=\"14\" data-index-in-node=\"0\"\u003eSequence:\u003c\/b\u003e Aib-His-D-2-Nal-D-Phe-Lys-NH2 \u003cb data-path-to-node=\"14\" data-index-in-node=\"40\"\u003eFormat:\u003c\/b\u003e Sterile Lyophilized Powder (Vial) \u003cb data-path-to-node=\"14\" data-index-in-node=\"82\"\u003eClass:\u003c\/b\u003e Selective Growth Hormone Secretagogue (GHS) \u003cb data-path-to-node=\"14\" data-index-in-node=\"133\"\u003ePurity:\u003c\/b\u003e \u0026gt;98% (HPLC) \u003cb data-path-to-node=\"14\" data-index-in-node=\"153\"\u003eContent:\u003c\/b\u003e 5mg per vial\u003c\/p\u003e\n\u003chr data-path-to-node=\"15\"\u003e\n\u003ch3 data-path-to-node=\"16\"\u003e\u003cb data-path-to-node=\"16\" data-index-in-node=\"0\"\u003eProduct Overview\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp data-path-to-node=\"17\"\u003e\u003cb data-path-to-node=\"17\" data-index-in-node=\"0\"\u003eIpamorelin\u003c\/b\u003e is a third-generation synthetic pentapeptide and a highly selective agonist of the \u003cb data-path-to-node=\"17\" data-index-in-node=\"94\"\u003eGhrelin Receptor (GHS-R1a)\u003c\/b\u003e. It is distinguished from earlier secretagogues (like GHRP-6 and GHRP-2) by its \u003cb data-path-to-node=\"17\" data-index-in-node=\"201\"\u003eexquisite selectivity\u003c\/b\u003e.\u003c\/p\u003e\n\u003cp data-path-to-node=\"18\"\u003eWhile promoting a potent pulsatile release of Growth Hormone (GH), Ipamorelin is unique in that it \u003cb data-path-to-node=\"18\" data-index-in-node=\"99\"\u003edoes not stimulate ACTH, Cortisol, or Prolactin\u003c\/b\u003e, even at high doses. This \"clean\" pharmacological profile makes it the preferred reagent for research requiring pure anabolic signaling without the \"endocrine noise\" of stress hormones.\u003c\/p\u003e\n\u003chr data-path-to-node=\"19\"\u003e\n\u003ch3 data-path-to-node=\"20\"\u003e\u003cb data-path-to-node=\"20\" data-index-in-node=\"0\"\u003eMechanism of Action: The Selective Pulse\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp data-path-to-node=\"21\"\u003eIpamorelin operates via the \u003cb data-path-to-node=\"21\" data-index-in-node=\"28\"\u003eGHS-R1a receptor\u003c\/b\u003e, initiating a cascade that mimics the body's natural growth hormone pulse.\u003c\/p\u003e\n\u003cul data-path-to-node=\"22\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"22,0,0\"\u003e\u003cb data-path-to-node=\"22,0,0\" data-index-in-node=\"0\"\u003eSelective GHS-R1a Activation:\u003c\/b\u003e Binds to pituitary receptors, triggering the Gq\/11-PLC-IP3 pathway. This mobilizes intracellular calcium to release GH vesicles.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"22,1,0\"\u003e\u003cb data-path-to-node=\"22,1,0\" data-index-in-node=\"0\"\u003eNo Stress Hormone Spike:\u003c\/b\u003e Unlike GHRPs, it avoids cross-reactivity with receptors that trigger cortisol or prolactin, preventing catabolic side effects.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"22,2,0\"\u003e\u003cb data-path-to-node=\"22,2,0\" data-index-in-node=\"0\"\u003eAnabolic Signaling:\u003c\/b\u003e The released GH stimulates the liver to produce \u003cb data-path-to-node=\"22,2,0\" data-index-in-node=\"68\"\u003eIGF-1\u003c\/b\u003e, which activates the \u003cb data-path-to-node=\"22,2,0\" data-index-in-node=\"95\"\u003emTORC1 pathway\u003c\/b\u003e in muscle (protein synthesis) and the \u003cb data-path-to-node=\"22,2,0\" data-index-in-node=\"148\"\u003eRunx2 pathway\u003c\/b\u003e in bone (osteoblast differentiation).\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003chr data-path-to-node=\"23\"\u003e\n\u003ch3 data-path-to-node=\"24\"\u003e\u003cb data-path-to-node=\"24\" data-index-in-node=\"0\"\u003eKey Research Applications\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp data-path-to-node=\"25\"\u003e\u003cb data-path-to-node=\"25\" data-index-in-node=\"0\"\u003e1. Musculoskeletal Growth \u0026amp; Recovery\u003c\/b\u003e Ipamorelin is the gold standard for pure anabolic research.\u003c\/p\u003e\n\u003cul data-path-to-node=\"26\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"26,0,0\"\u003e\u003cb data-path-to-node=\"26,0,0\" data-index-in-node=\"0\"\u003eHypertrophy:\u003c\/b\u003e Drives muscle protein synthesis via mTOR activation without cortisol-induced muscle wasting.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"26,1,0\"\u003e\u003cb data-path-to-node=\"26,1,0\" data-index-in-node=\"0\"\u003eBone Density:\u003c\/b\u003e Studies (Johansen et al.) show it increases Longitudinal Bone Growth Rate (LGR) and bone mineral content by stimulating osteoblasts, even counteracting glucocorticoid-induced bone loss.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp data-path-to-node=\"27\"\u003e\u003cb data-path-to-node=\"27\" data-index-in-node=\"0\"\u003e2. Metabolic Regulation \u0026amp; Body Composition\u003c\/b\u003e\u003c\/p\u003e\n\u003cul data-path-to-node=\"28\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"28,0,0\"\u003e\u003cb data-path-to-node=\"28,0,0\" data-index-in-node=\"0\"\u003eLipolysis:\u003c\/b\u003e Promotes fat loss by increasing metabolic rate and fatty acid oxidation.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"28,1,0\"\u003e\u003cb data-path-to-node=\"28,1,0\" data-index-in-node=\"0\"\u003eNitrogen Balance:\u003c\/b\u003e Improves whole-body nitrogen retention by downregulating urea cycle enzymes in the liver, preserving amino acids for tissue repair.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp data-path-to-node=\"29\"\u003e\u003cb data-path-to-node=\"29\" data-index-in-node=\"0\"\u003e3. Gastrointestinal Motility\u003c\/b\u003e\u003c\/p\u003e\n\u003cul data-path-to-node=\"30\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"30,0,0\"\u003e\u003cb data-path-to-node=\"30,0,0\" data-index-in-node=\"0\"\u003ePostoperative Ileus:\u003c\/b\u003e Accelerates gastric emptying and reverses bowel paralysis (ileus) following surgery via cholinergic pathways in the gut, aiding recovery.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003chr data-path-to-node=\"31\"\u003e\n\u003ch3 data-path-to-node=\"32\"\u003e\u003cb data-path-to-node=\"32\" data-index-in-node=\"0\"\u003eStorage \u0026amp; Handling\u003c\/b\u003e\u003c\/h3\u003e\n\u003cul data-path-to-node=\"33\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"33,0,0\"\u003e\u003cb data-path-to-node=\"33,0,0\" data-index-in-node=\"0\"\u003ePhysical State:\u003c\/b\u003e Lyophilized (Freeze-Dried) White Powder.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"33,1,0\"\u003e\u003cb data-path-to-node=\"33,1,0\" data-index-in-node=\"0\"\u003eStorage (Powder):\u003c\/b\u003e Store at -20°C (Freezer). Stable for up to 36 months.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"33,2,0\"\u003e\u003cb data-path-to-node=\"33,2,0\" data-index-in-node=\"0\"\u003eReconstitution:\u003c\/b\u003e\u003c\/p\u003e\n\u003cul data-path-to-node=\"33,2,1\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"33,2,1,0,0\"\u003e\u003cb data-path-to-node=\"33,2,1,0,0\" data-index-in-node=\"0\"\u003eSolvent:\u003c\/b\u003e Bacteriostatic Water or Sterile Saline.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"33,2,1,1,0\"\u003e\u003cb data-path-to-node=\"33,2,1,1,0\" data-index-in-node=\"0\"\u003eSolubility:\u003c\/b\u003e Highly soluble.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"33,3,0\"\u003e\u003cb data-path-to-node=\"33,3,0\" data-index-in-node=\"0\"\u003eStorage (Liquid):\u003c\/b\u003e Store at 4°C (Refrigerator).\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003chr data-path-to-node=\"34\"\u003e\n\u003ch3 data-path-to-node=\"35\"\u003e\u003cb data-path-to-node=\"35\" data-index-in-node=\"0\"\u003eDisclaimer\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp data-path-to-node=\"36\"\u003e\u003cb data-path-to-node=\"36\" data-index-in-node=\"0\"\u003eFOR RESEARCH USE ONLY.\u003c\/b\u003e This product is a chemical compound intended strictly for laboratory research and development. It is not approved by the FDA for clinical use, diagnostics, or therapeutic procedures in humans or animals. The physiological and toxicological properties of this chemical have not been fully investigated.\u003c\/p\u003e","brand":"Peptagon","offers":[{"title":"Default Title","offer_id":47712309870806,"sku":"IPAMOR-10","price":31.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0783\/3085\/5638\/files\/Ipamorelin-10mg.png?v=1768509242"},{"product_id":"kisspeptin-metastin-45-54-research-peptide","title":"Kisspeptin Research Peptide – 5mg \/ 10mg","description":"\u003ch4 data-path-to-node=\"13\"\u003e\u003cstrong\u003eKisspeptin Peptide (Lyophilized)\u003c\/strong\u003e\u003c\/h4\u003e\n\u003cp data-path-to-node=\"14\"\u003e\u003cb data-path-to-node=\"14\" data-index-in-node=\"0\"\u003eSequence:\u003c\/b\u003e YNWNSFGLRF-NH2 (Metastin residues 45-54) \u003cb data-path-to-node=\"14\" data-index-in-node=\"51\"\u003eFormat:\u003c\/b\u003e Sterile Lyophilized Powder (Vial) \u003cb data-path-to-node=\"14\" data-index-in-node=\"93\"\u003eReceptor:\u003c\/b\u003e KISS1R (GPR54) Agonist \u003cb data-path-to-node=\"14\" data-index-in-node=\"126\"\u003ePurity:\u003c\/b\u003e \u0026gt;98% (HPLC) \u003cb data-path-to-node=\"14\" data-index-in-node=\"146\"\u003eContent:\u003c\/b\u003e 10mg per vial\u003c\/p\u003e\n\u003chr data-path-to-node=\"15\"\u003e\n\u003ch3 data-path-to-node=\"16\"\u003e\u003cb data-path-to-node=\"16\" data-index-in-node=\"0\"\u003eProduct Overview\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp data-path-to-node=\"17\"\u003e\u003cb data-path-to-node=\"17\" data-index-in-node=\"0\"\u003eKisspeptin-10 (KP-10)\u003c\/b\u003e is the bioactive C-terminal decapeptide of the larger Kisspeptin-54 protein. It acts as the \"master switch\" of the Hypothalamic-Pituitary-Gonadal (HPG) axis.\u003c\/p\u003e\n\u003cp data-path-to-node=\"18\"\u003eResearch has established KP-10 as a potent secretagogue of \u003cb data-path-to-node=\"18\" data-index-in-node=\"59\"\u003eGonadotropin-Releasing Hormone (GnRH)\u003c\/b\u003e. By binding to the KISS1R receptor on GnRH neurons, it triggers the release of Luteinizing Hormone (LH) and Follicle-Stimulating Hormone (FSH), making it a critical tool for investigating fertility, testosterone production, and the neuroendocrine control of reproduction.\u003c\/p\u003e\n\u003chr data-path-to-node=\"19\"\u003e\n\u003ch3 data-path-to-node=\"20\"\u003e\u003cb data-path-to-node=\"20\" data-index-in-node=\"0\"\u003eMechanism of Action: The HPG Gatekeeper\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp data-path-to-node=\"21\"\u003eKisspeptin-10 functions via the Gq\/11-Phospholipase C pathway to depolarize GnRH neurons.\u003c\/p\u003e\n\u003cul data-path-to-node=\"22\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"22,0,0\"\u003e\u003cb data-path-to-node=\"22,0,0\" data-index-in-node=\"0\"\u003eGnRH Stimulation:\u003c\/b\u003e Binds to KISS1R on GnRH neurons in the hypothalamus, inhibiting potassium channels and activating TRPC channels. This causes rapid depolarization and pulsatile release of GnRH.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"22,1,0\"\u003e\u003cb data-path-to-node=\"22,1,0\" data-index-in-node=\"0\"\u003eMetabolic Integration:\u003c\/b\u003e Acts as a bridge between metabolism and reproduction. Its expression is regulated by \u003cb data-path-to-node=\"22,1,0\" data-index-in-node=\"108\"\u003eLeptin\u003c\/b\u003e, ensuring that reproductive function is coupled to energy availability.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"22,2,0\"\u003e\u003cb data-path-to-node=\"22,2,0\" data-index-in-node=\"0\"\u003eOncology (Metastasis):\u003c\/b\u003e Originally identified as \"Metastin,\" KP-10 suppresses metastasis in melanoma by inhibiting MMP-9 and inducing dormancy in disseminated tumor cells.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003chr data-path-to-node=\"23\"\u003e\n\u003ch3 data-path-to-node=\"24\"\u003e\u003cb data-path-to-node=\"24\" data-index-in-node=\"0\"\u003eKey Research Applications\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp data-path-to-node=\"25\"\u003e\u003cb data-path-to-node=\"25\" data-index-in-node=\"0\"\u003e1. Testosterone \u0026amp; Fertility\u003c\/b\u003e KP-10 is widely investigated for its ability to stimulate the release of LH and Testosterone in men without the testicular atrophy associated with exogenous TRT. It restores the HPG axis in conditions of hypogonadotropic hypogonadism.\u003c\/p\u003e\n\u003cp data-path-to-node=\"26\"\u003e\u003cb data-path-to-node=\"26\" data-index-in-node=\"0\"\u003e2. Metabolic Syndrome\u003c\/b\u003e Recent studies indicate that KP-10 can reverse the effects of a high-fat diet. In animal models, it reduced body weight, normalized blood glucose, and increased GLP-1 secretion, suggesting a role in treating obesity-related hypogonadism.\u003c\/p\u003e\n\u003cp data-path-to-node=\"27\"\u003e\u003cb data-path-to-node=\"27\" data-index-in-node=\"0\"\u003e3. Behavioral Neuroscience\u003c\/b\u003e Research using fMRI has shown that Kisspeptin administration enhances limbic brain activity in response to sexual and emotional stimuli, reducing sexual aversion and boosting social motivation and mood.\u003c\/p\u003e\n\u003chr data-path-to-node=\"28\"\u003e\n\u003ch3 data-path-to-node=\"29\"\u003e\u003cb data-path-to-node=\"29\" data-index-in-node=\"0\"\u003eStorage \u0026amp; Handling\u003c\/b\u003e\u003c\/h3\u003e\n\u003cul data-path-to-node=\"30\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"30,0,0\"\u003e\u003cb data-path-to-node=\"30,0,0\" data-index-in-node=\"0\"\u003ePhysical State:\u003c\/b\u003e Lyophilized (Freeze-Dried) White Powder.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"30,1,0\"\u003e\u003cb data-path-to-node=\"30,1,0\" data-index-in-node=\"0\"\u003eStorage (Powder):\u003c\/b\u003e Store at -20°C (Freezer). Stable for up to 36 months.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"30,2,0\"\u003e\u003cb data-path-to-node=\"30,2,0\" data-index-in-node=\"0\"\u003eReconstitution:\u003c\/b\u003e\u003c\/p\u003e\n\u003cul data-path-to-node=\"30,2,1\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"30,2,1,0,0\"\u003e\u003cb data-path-to-node=\"30,2,1,0,0\" data-index-in-node=\"0\"\u003eSolvent:\u003c\/b\u003e Sterile Water or Saline.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"30,2,1,1,0\"\u003e\u003cb data-path-to-node=\"30,2,1,1,0\" data-index-in-node=\"0\"\u003eSolubility:\u003c\/b\u003e Highly soluble.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"30,3,0\"\u003e\u003cb data-path-to-node=\"30,3,0\" data-index-in-node=\"0\"\u003eStorage (Liquid):\u003c\/b\u003e Store at 4°C (Refrigerator). \u003cb data-path-to-node=\"30,3,0\" data-index-in-node=\"47\"\u003eUse within 2-3 days.\u003c\/b\u003e KP-10 degrades rapidly in solution due to N-terminal cleavage; freeze single-use aliquots for longer storage.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003chr data-path-to-node=\"31\"\u003e\n\u003ch3 data-path-to-node=\"32\"\u003e\u003cb data-path-to-node=\"32\" data-index-in-node=\"0\"\u003eDisclaimer\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp data-path-to-node=\"33\"\u003e\u003cb data-path-to-node=\"33\" data-index-in-node=\"0\"\u003eFOR RESEARCH USE ONLY.\u003c\/b\u003e This product is a chemical compound intended strictly for laboratory research and development. It is not approved by the FDA for clinical use, diagnostics, or therapeutic procedures in humans or animals. The physiological and toxicological properties of this chemical have not been fully investigated.\u003c\/p\u003e","brand":"Peptagon","offers":[{"title":"5mg","offer_id":47712310460630,"sku":"KISSP-5","price":30.0,"currency_code":"USD","in_stock":true},{"title":"10mg","offer_id":47712310493398,"sku":"KISSP-10","price":38.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0783\/3085\/5638\/files\/Kisspeptin-5mg.png?v=1768510822"},{"product_id":"kpv-alpha-msh-11-13-research-peptide","title":"KPV Research Peptide – 10mg","description":"\u003ch4 data-path-to-node=\"13\"\u003e\u003cstrong\u003eKPV Peptide (Lyophilized)\u003c\/strong\u003e\u003c\/h4\u003e\n\u003cp data-path-to-node=\"14\"\u003e\u003cb data-path-to-node=\"14\" data-index-in-node=\"0\"\u003eSequence:\u003c\/b\u003e Lys-Pro-Val (Alpha-MSH residues 11-13) \u003cb data-path-to-node=\"14\" data-index-in-node=\"49\"\u003eFormat:\u003c\/b\u003e Sterile Lyophilized Powder (Vial) \u003cb data-path-to-node=\"14\" data-index-in-node=\"91\"\u003eMechanism:\u003c\/b\u003e Nuclear NF-κB Translocation Inhibitor \u003cb data-path-to-node=\"14\" data-index-in-node=\"140\"\u003ePurity:\u003c\/b\u003e \u0026gt;98% (HPLC) \u003cb data-path-to-node=\"14\" data-index-in-node=\"160\"\u003eContent:\u003c\/b\u003e 10mg per vial\u003c\/p\u003e\n\u003chr data-path-to-node=\"15\"\u003e\n\u003ch3 data-path-to-node=\"16\"\u003e\u003cb data-path-to-node=\"16\" data-index-in-node=\"0\"\u003eProduct Overview\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp data-path-to-node=\"17\"\u003e\u003cb data-path-to-node=\"17\" data-index-in-node=\"0\"\u003eKPV\u003c\/b\u003e is a naturally occurring tripeptide derived from the C-terminus of Alpha-Melanocyte Stimulating Hormone (α-MSH). It retains the potent anti-inflammatory and antimicrobial properties of the parent hormone but lacks the pigmentary effects (skin darkening) associated with full-length α-MSH.\u003c\/p\u003e\n\u003cp data-path-to-node=\"18\"\u003eUnlike traditional anti-inflammatories that suppress the entire immune system, KPV acts as a targeted modulator. It utilizes the \u003cb data-path-to-node=\"18\" data-index-in-node=\"129\"\u003ePepT1 transporter\u003c\/b\u003e, which is upregulated in inflamed tissues, to enter cells and block inflammatory signaling at the nuclear level. This \"seek-and-destroy\" mechanism makes it a primary candidate for researching inflammatory bowel disease (IBD), dermatitis, and wound healing.\u003c\/p\u003e\n\u003chr data-path-to-node=\"19\"\u003e\n\u003ch3 data-path-to-node=\"20\"\u003e\u003cb data-path-to-node=\"20\" data-index-in-node=\"0\"\u003eMechanism of Action: The Nuclear Shield\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp data-path-to-node=\"21\"\u003eKPV functions primarily by inhibiting the \u003cb data-path-to-node=\"21\" data-index-in-node=\"42\"\u003eNF-κB\u003c\/b\u003e pathway, the master regulator of inflammation.\u003c\/p\u003e\n\u003cul data-path-to-node=\"22\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"22,0,0\"\u003e\u003cb data-path-to-node=\"22,0,0\" data-index-in-node=\"0\"\u003eNuclear Import Blockade:\u003c\/b\u003e KPV enters the cell and binds to \u003cb data-path-to-node=\"22,0,0\" data-index-in-node=\"58\"\u003eImportin-alpha3\u003c\/b\u003e. This physically blocks the transport of NF-κB into the nucleus, preventing the transcription of pro-inflammatory cytokines like TNF-alpha and IL-6.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"22,1,0\"\u003e\u003cb data-path-to-node=\"22,1,0\" data-index-in-node=\"0\"\u003eTargeted Delivery:\u003c\/b\u003e It is actively transported into inflamed cells via the PepT1 transporter, accumulating precisely where inflammation is highest while sparing healthy tissue.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"22,2,0\"\u003e\u003cb data-path-to-node=\"22,2,0\" data-index-in-node=\"0\"\u003eAntimicrobial Activity:\u003c\/b\u003e KPV is cationic and disrupts the membranes of pathogens. Research shows it kills 95-97% of \u003ci data-path-to-node=\"22,2,0\" data-index-in-node=\"115\"\u003eS. aureus\u003c\/i\u003e (including MRSA) and \u003ci data-path-to-node=\"22,2,0\" data-index-in-node=\"146\"\u003eC. albicans\u003c\/i\u003e within hours.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003chr data-path-to-node=\"23\"\u003e\n\u003ch3 data-path-to-node=\"24\"\u003e\u003cb data-path-to-node=\"24\" data-index-in-node=\"0\"\u003eKey Research Applications\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp data-path-to-node=\"25\"\u003e\u003cb data-path-to-node=\"25\" data-index-in-node=\"0\"\u003e1. Inflammatory Bowel Disease (IBD)\u003c\/b\u003e In murine colitis models, oral KPV administration significantly reduced weight loss, colonic inflammation (MPO activity), and pro-inflammatory cytokine levels. Its efficacy is enhanced by hydrogel delivery systems that target the inflamed colon.\u003c\/p\u003e\n\u003cp data-path-to-node=\"26\"\u003e\u003cb data-path-to-node=\"26\" data-index-in-node=\"0\"\u003e2. Dermatology \u0026amp; Wound Healing\u003c\/b\u003e KPV accelerates wound closure and reduces scarring.\u003c\/p\u003e\n\u003cul data-path-to-node=\"27\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"27,0,0\"\u003e\u003cb data-path-to-node=\"27,0,0\" data-index-in-node=\"0\"\u003eRe-epithelialization:\u003c\/b\u003e Promotes rapid keratinocyte migration, closing wounds faster.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"27,1,0\"\u003e\u003cb data-path-to-node=\"27,1,0\" data-index-in-node=\"0\"\u003eAnti-Fibrotic:\u003c\/b\u003e Reduces inflammation early in the healing process, preventing the excessive collagen deposition that leads to scars.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"27,2,0\"\u003e\u003cb data-path-to-node=\"27,2,0\" data-index-in-node=\"0\"\u003ePsoriasis\/Dermatitis:\u003c\/b\u003e Investigated for its ability to calm skin inflammation without the side effects of topical steroids.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp data-path-to-node=\"28\"\u003e\u003cb data-path-to-node=\"28\" data-index-in-node=\"0\"\u003e3. Antimicrobial Defense\u003c\/b\u003e Unlike antibiotics, KPV has a dual mechanism: it kills bacteria\/fungi directly via membrane disruption \u003ci data-path-to-node=\"28\" data-index-in-node=\"128\"\u003eand\u003c\/i\u003e suppresses the host inflammation caused by the infection. It is effective against biofilms and resistant strains like MRSA.\u003c\/p\u003e\n\u003chr data-path-to-node=\"29\"\u003e\n\u003ch3 data-path-to-node=\"30\"\u003e\u003cb data-path-to-node=\"30\" data-index-in-node=\"0\"\u003eStorage \u0026amp; Handling\u003c\/b\u003e\u003c\/h3\u003e\n\u003cul data-path-to-node=\"31\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"31,0,0\"\u003e\u003cb data-path-to-node=\"31,0,0\" data-index-in-node=\"0\"\u003ePhysical State:\u003c\/b\u003e Lyophilized (Freeze-Dried) White Powder.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"31,1,0\"\u003e\u003cb data-path-to-node=\"31,1,0\" data-index-in-node=\"0\"\u003eStorage (Powder):\u003c\/b\u003e Store at -20°C (Freezer). Stable for up to 36 months.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"31,2,0\"\u003e\u003cb data-path-to-node=\"31,2,0\" data-index-in-node=\"0\"\u003eReconstitution:\u003c\/b\u003e\u003c\/p\u003e\n\u003cul data-path-to-node=\"31,2,1\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"31,2,1,0,0\"\u003e\u003cb data-path-to-node=\"31,2,1,0,0\" data-index-in-node=\"0\"\u003eSolvent:\u003c\/b\u003e Sterile Water or Saline.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"31,2,1,1,0\"\u003e\u003cb data-path-to-node=\"31,2,1,1,0\" data-index-in-node=\"0\"\u003eSolubility:\u003c\/b\u003e Highly soluble due to hydrophilic residues.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"31,3,0\"\u003e\u003cb data-path-to-node=\"31,3,0\" data-index-in-node=\"0\"\u003eStorage (Liquid):\u003c\/b\u003e Store at 4°C (Refrigerator). Use within 14-21 days.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003chr data-path-to-node=\"32\"\u003e\n\u003ch3 data-path-to-node=\"33\"\u003e\u003cb data-path-to-node=\"33\" data-index-in-node=\"0\"\u003eDisclaimer\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp data-path-to-node=\"34\"\u003e\u003cb data-path-to-node=\"34\" data-index-in-node=\"0\"\u003eFOR RESEARCH USE ONLY.\u003c\/b\u003e This product is a chemical compound intended strictly for laboratory research and development. It is not approved by the FDA for clinical use, diagnostics, or therapeutic procedures in humans or animals. The physiological and toxicological properties of this chemical have not been fully investigated.\u003c\/p\u003e","brand":"Peptagon","offers":[{"title":"Default Title","offer_id":47712310952150,"sku":"KPV-10","price":31.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0783\/3085\/5638\/files\/KPV-10mg.png?v=1768507503"},{"product_id":"ll-37-human-cathelicidin-research-peptide","title":"LL-37 Research Peptide – 5mg \/ 10mg","description":"\u003ch2 data-path-to-node=\"13\"\u003e\u003cstrong\u003eLL-37 Peptide (Lyophilized)\u003c\/strong\u003e\u003c\/h2\u003e\n\u003ch2 data-section-id=\"1qhk4i3\" data-start=\"940\" data-end=\"959\"\u003eSpecifications\u003c\/h2\u003e\n\u003cp data-start=\"960\" data-end=\"1168\"\u003e\u003cstrong data-start=\"960\" data-end=\"973\"\u003eSequence:\u003c\/strong\u003e LLGDFFRKSK EKIGKEFKRI VQRIKDFLRN LVPRTES\u003cbr data-start=\"1014\" data-end=\"1017\"\u003e\u003cstrong data-start=\"1017\" data-end=\"1028\"\u003eFormat:\u003c\/strong\u003e Sterile Lyophilized Powder (Vial)\u003cbr data-start=\"1062\" data-end=\"1065\"\u003e\u003cstrong data-start=\"1065\" data-end=\"1077\"\u003eContent:\u003c\/strong\u003e 10mg per vial\u003cbr data-start=\"1091\" data-end=\"1094\"\u003e\u003cstrong data-start=\"1094\" data-end=\"1104\"\u003eClass:\u003c\/strong\u003e Host Defense Peptide (Cathelicidin)\u003cbr data-start=\"1140\" data-end=\"1143\"\u003e\u003cstrong data-start=\"1143\" data-end=\"1154\"\u003ePurity:\u003c\/strong\u003e ≥98% (HPLC)\u003c\/p\u003e\n\u003cp data-start=\"1170\" data-end=\"1259\"\u003e\u003cstrong data-start=\"1170\" data-end=\"1187\"\u003eIntended Use:\u003c\/strong\u003e For laboratory research purposes only. Not for human or veterinary use.\u003c\/p\u003e\n\u003chr data-start=\"1261\" data-end=\"1264\"\u003e\n\u003ch2 data-section-id=\"53drpp\" data-start=\"1266\" data-end=\"1287\"\u003eProduct Overview\u003c\/h2\u003e\n\u003cp data-start=\"1289\" data-end=\"1592\"\u003eLL-37 is the only cathelicidin-derived peptide identified in humans and plays a central role in innate immune system signaling. It is classified as a host defense peptide and is widely studied for its interaction with microbial membranes, immune signaling pathways, and cellular communication processes.\u003c\/p\u003e\n\u003cp data-start=\"1594\" data-end=\"1903\"\u003eLL-37 functions as a multifunctional signaling peptide, participating in antimicrobial defense, immune cell recruitment, and modulation of inflammatory pathways. Unlike traditional small-molecule antibiotics, LL-37 operates through biophysical membrane interactions and receptor-mediated signaling mechanisms.\u003c\/p\u003e\n\u003cp data-start=\"1905\" data-end=\"2092\"\u003eIn research settings, LL-37 is utilized to investigate antimicrobial peptide behavior, host-pathogen interactions, and signaling pathways associated with inflammation and tissue response.\u003c\/p\u003e\n\u003chr data-start=\"2094\" data-end=\"2097\"\u003e\n\u003ch2 data-section-id=\"10snmn7\" data-start=\"2099\" data-end=\"2121\"\u003eWhy This Peptide?\u003c\/h2\u003e\n\u003cp data-start=\"2123\" data-end=\"2287\"\u003eLL-37 is one of the most extensively studied human antimicrobial peptides due to its dual role in both direct microbial interaction and immune signaling modulation.\u003c\/p\u003e\n\u003cp data-start=\"2289\" data-end=\"2317\"\u003eKey characteristics include:\u003c\/p\u003e\n\u003cul data-start=\"2319\" data-end=\"2605\"\u003e\n\u003cli data-section-id=\"1t6ipz0\" data-start=\"2319\" data-end=\"2384\"\u003eAmphipathic α-helical structure enabling membrane interaction\u003c\/li\u003e\n\u003cli data-section-id=\"cn3lwm\" data-start=\"2385\" data-end=\"2446\"\u003eBroad interaction with microbial membranes and endotoxins\u003c\/li\u003e\n\u003cli data-section-id=\"grioyr\" data-start=\"2447\" data-end=\"2518\"\u003eInvolvement in immune signaling and cellular communication pathways\u003c\/li\u003e\n\u003cli data-section-id=\"171p6jh\" data-start=\"2519\" data-end=\"2605\"\u003eActivity across multiple research models (microbial, immune, and tissue signaling)\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp data-start=\"2607\" data-end=\"2690\"\u003eThese features make LL-37 a foundational compound in host defense peptide research.\u003c\/p\u003e\n\u003chr data-start=\"2692\" data-end=\"2695\"\u003e\n\u003ch2 data-section-id=\"178yx1o\" data-start=\"2697\" data-end=\"2766\"\u003eMechanism of Action: Membrane Interaction \u0026amp; Signaling Modulation\u003c\/h2\u003e\n\u003cp data-start=\"2768\" data-end=\"2859\"\u003eLL-37 exhibits a multimodal mechanism depending on environmental context and concentration.\u003c\/p\u003e\n\u003ch3 data-section-id=\"vshl77\" data-start=\"2861\" data-end=\"2911\"\u003eMembrane Interaction (Antimicrobial Context)\u003c\/h3\u003e\n\u003cp data-start=\"2912\" data-end=\"3103\"\u003eLL-37 forms an amphipathic α-helix that interacts with negatively charged microbial membranes. This interaction can lead to membrane destabilization and pore formation in experimental models.\u003c\/p\u003e\n\u003ch3 data-section-id=\"iz6jw6\" data-start=\"3105\" data-end=\"3130\"\u003eBiofilm Interaction\u003c\/h3\u003e\n\u003cp data-start=\"3131\" data-end=\"3317\"\u003eLL-37 has been studied in models examining bacterial quorum sensing systems and biofilm formation dynamics, including effects on signaling pathways associated with microbial aggregation.\u003c\/p\u003e\n\u003ch3 data-section-id=\"xq70dp\" data-start=\"3319\" data-end=\"3348\"\u003eEndotoxin (LPS) Binding\u003c\/h3\u003e\n\u003cp data-start=\"3349\" data-end=\"3509\"\u003eLL-37 binds lipopolysaccharide (LPS), allowing investigation into pathways related to Toll-like receptor (TLR4) signaling and downstream inflammatory responses.\u003c\/p\u003e\n\u003ch3 data-section-id=\"hydtql\" data-start=\"3511\" data-end=\"3544\"\u003eImmune Signaling Modulation\u003c\/h3\u003e\n\u003cp data-start=\"3545\" data-end=\"3625\"\u003eLL-37 interacts with multiple receptors involved in immune signaling, including:\u003c\/p\u003e\n\u003cul data-start=\"3627\" data-end=\"3713\"\u003e\n\u003cli data-section-id=\"69c971\" data-start=\"3627\" data-end=\"3661\"\u003eFPR2 (formyl peptide receptor)\u003c\/li\u003e\n\u003cli data-section-id=\"1s7xh4d\" data-start=\"3662\" data-end=\"3679\"\u003eP2X7 receptor\u003c\/li\u003e\n\u003cli data-section-id=\"o5ut7l\" data-start=\"3680\" data-end=\"3713\"\u003eEGFR transactivation pathways\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp data-start=\"3715\" data-end=\"3829\"\u003eThese interactions are studied in relation to immune cell recruitment, signaling cascades, and pathway modulation.\u003c\/p\u003e\n\u003chr data-start=\"3831\" data-end=\"3834\"\u003e\n\u003ch2 data-section-id=\"1k1p0ls\" data-start=\"3836\" data-end=\"3867\"\u003ePreclinical Research Areas\u003c\/h2\u003e\n\u003cp data-start=\"3869\" data-end=\"4054\"\u003e\u003cstrong data-start=\"3869\" data-end=\"3906\"\u003e1. Antimicrobial Peptide Research\u003c\/strong\u003e\u003cbr data-start=\"3906\" data-end=\"3909\"\u003eStudied in models involving Gram-positive, Gram-negative, and fungal organisms, focusing on membrane interaction and microbial response pathways.\u003c\/p\u003e\n\u003cp data-start=\"4056\" data-end=\"4183\"\u003e\u003cstrong data-start=\"4056\" data-end=\"4099\"\u003e2. Biofilm \u0026amp; Microbial Signaling Models\u003c\/strong\u003e\u003cbr data-start=\"4099\" data-end=\"4102\"\u003eUsed in research examining quorum sensing systems and biofilm formation dynamics.\u003c\/p\u003e\n\u003cp data-start=\"4185\" data-end=\"4348\"\u003e\u003cstrong data-start=\"4185\" data-end=\"4232\"\u003e3. Immune Signaling \u0026amp; Inflammation Research\u003c\/strong\u003e\u003cbr data-start=\"4232\" data-end=\"4235\"\u003eInvestigated for its role in immune cell signaling, cytokine pathway modulation, and receptor-level interactions.\u003c\/p\u003e\n\u003cp data-start=\"4350\" data-end=\"4516\"\u003e\u003cstrong data-start=\"4350\" data-end=\"4391\"\u003e4. Tissue \u0026amp; Cellular Signaling Models\u003c\/strong\u003e\u003cbr data-start=\"4391\" data-end=\"4394\"\u003eStudied in keratinocyte and endothelial cell models to evaluate signaling pathways associated with cellular communication.\u003c\/p\u003e\n\u003cp data-start=\"4518\" data-end=\"4709\"\u003e\u003cstrong data-start=\"4518\" data-end=\"4566\"\u003e5. Oncology Signaling Context (Experimental)\u003c\/strong\u003e\u003cbr data-start=\"4566\" data-end=\"4569\"\u003eLL-37 has been evaluated in models examining signaling pathways in different tissue environments, with context-dependent effects observed.\u003c\/p\u003e\n\u003chr data-start=\"4711\" data-end=\"4714\"\u003e\n\u003ch2 data-section-id=\"ce0tqk\" data-start=\"4716\" data-end=\"4733\"\u003eApplications\u003c\/h2\u003e\n\u003cul data-start=\"4735\" data-end=\"4944\"\u003e\n\u003cli data-section-id=\"blzgyi\" data-start=\"4735\" data-end=\"4776\"\u003eAntimicrobial peptide research models\u003c\/li\u003e\n\u003cli data-section-id=\"1y19lfu\" data-start=\"4777\" data-end=\"4815\"\u003eBiofilm and quorum sensing studies\u003c\/li\u003e\n\u003cli data-section-id=\"1k4sqk1\" data-start=\"4816\" data-end=\"4853\"\u003eImmune signaling pathway analysis\u003c\/li\u003e\n\u003cli data-section-id=\"1aozsy0\" data-start=\"4854\" data-end=\"4905\"\u003eCell culture (keratinocyte, immune cell models)\u003c\/li\u003e\n\u003cli data-section-id=\"1e0nmmg\" data-start=\"4906\" data-end=\"4944\"\u003eHost-pathogen interaction research\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003chr data-start=\"4946\" data-end=\"4949\"\u003e\n\u003ch2 data-section-id=\"1jtb6ys\" data-start=\"4951\" data-end=\"4975\"\u003eResearch Advantages\u003c\/h2\u003e\n\u003cul data-start=\"4977\" data-end=\"5270\"\u003e\n\u003cli data-section-id=\"4zq4gk\" data-start=\"4977\" data-end=\"5015\"\u003eHuman-derived host defense peptide\u003c\/li\u003e\n\u003cli data-section-id=\"5pj6xb\" data-start=\"5016\" data-end=\"5079\"\u003eAmphipathic structure enabling membrane interaction studies\u003c\/li\u003e\n\u003cli data-section-id=\"958lu5\" data-start=\"5080\" data-end=\"5147\"\u003eBroad applicability across microbial and immune research models\u003c\/li\u003e\n\u003cli data-section-id=\"1dil6zk\" data-start=\"5148\" data-end=\"5205\"\u003eMulti-pathway signaling relevance (immune + cellular)\u003c\/li\u003e\n\u003cli data-section-id=\"1ocm8cy\" data-start=\"5206\" data-end=\"5270\"\u003eWell-characterized peptide with extensive literature support\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003chr data-start=\"5272\" data-end=\"5275\"\u003e\n\u003ch2 data-section-id=\"1qk69px\" data-start=\"5277\" data-end=\"5300\"\u003eStorage \u0026amp; Handling\u003c\/h2\u003e\n\u003cp data-start=\"5302\" data-end=\"5357\"\u003e\u003cstrong data-start=\"5302\" data-end=\"5321\"\u003ePhysical State:\u003c\/strong\u003e Lyophilized (freeze-dried) powder\u003c\/p\u003e\n\u003cp data-start=\"5359\" data-end=\"5426\"\u003e\u003cstrong data-start=\"5359\" data-end=\"5380\"\u003eStorage (Powder):\u003c\/strong\u003e Store at -20°C. Stable for extended storage\u003c\/p\u003e\n\u003cp data-start=\"5428\" data-end=\"5449\"\u003e\u003cstrong data-start=\"5428\" data-end=\"5447\"\u003eReconstitution:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cul data-start=\"5450\" data-end=\"5586\"\u003e\n\u003cli data-section-id=\"99vxfy\" data-start=\"5450\" data-end=\"5471\"\u003eUse sterile water\u003c\/li\u003e\n\u003cli data-section-id=\"twzdsl\" data-start=\"5472\" data-end=\"5532\"\u003eAvoid high-salt buffers initially to prevent aggregation\u003c\/li\u003e\n\u003cli data-section-id=\"19zbkhw\" data-start=\"5533\" data-end=\"5586\"\u003eUse low-binding labware (LL-37 adheres to surfaces)\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp data-start=\"5588\" data-end=\"5661\"\u003e\u003cstrong data-start=\"5588\" data-end=\"5609\"\u003eStorage (Liquid):\u003c\/strong\u003e\u003cbr data-start=\"5609\" data-end=\"5612\"\u003eStore at 4°C and use within a limited timeframe\u003c\/p\u003e\n\u003chr data-start=\"5663\" data-end=\"5666\"\u003e\n\u003ch2 data-section-id=\"9rcx7q\" data-start=\"5668\" data-end=\"5683\"\u003eDisclaimer\u003c\/h2\u003e\n\u003cp data-start=\"5685\" data-end=\"6009\"\u003eFOR RESEARCH USE ONLY. This product is a chemical compound intended strictly for laboratory research and development. It is not approved by the FDA for clinical use, diagnostics, or therapeutic procedures in humans or animals. The physiological and toxicological properties of this chemical have not been fully investigated.\u003c\/p\u003e","brand":"Peptagon","offers":[{"title":"5mg","offer_id":48170384949462,"sku":"LL37-NC-5","price":33.0,"currency_code":"USD","in_stock":false},{"title":"10mg","offer_id":48170384982230,"sku":"LL37-NC-10","price":63.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0783\/3085\/5638\/files\/LL-37-5mg.png?v=1768507525"},{"product_id":"ll-37-complex-human-cathelicidin-research-peptide","title":"LL-37 Complex Research Peptide – 5mg","description":"\u003ch4 data-path-to-node=\"13\"\u003e\u003cstrong\u003eLL-37 Complex Peptide (Lyophilized)\u003c\/strong\u003e\u003c\/h4\u003e\n\u003cp data-path-to-node=\"14\"\u003e\u003cb data-path-to-node=\"14\" data-index-in-node=\"0\"\u003eSequence:\u003c\/b\u003e LLGDFFRKSK EKIGKEFKRI VQRIKDFLRN LVPRTES \u003cb data-path-to-node=\"14\" data-index-in-node=\"51\"\u003eFormat:\u003c\/b\u003e Sterile Lyophilized Powder (Vial) \u003cb data-path-to-node=\"14\" data-index-in-node=\"93\"\u003eStructure:\u003c\/b\u003e Amphipathic Alpha-Helix \u003cb data-path-to-node=\"14\" data-index-in-node=\"128\"\u003ePurity:\u003c\/b\u003e \u0026gt;95% (HPLC) \u003cb data-path-to-node=\"14\" data-index-in-node=\"148\"\u003eContent:\u003c\/b\u003e 5mg per vial\u003c\/p\u003e\n\u003chr data-path-to-node=\"15\"\u003e\n\u003ch3 data-path-to-node=\"16\"\u003e\u003cb data-path-to-node=\"16\" data-index-in-node=\"0\"\u003eProduct Overview\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp data-path-to-node=\"17\"\u003e\u003cb data-path-to-node=\"17\" data-index-in-node=\"0\"\u003eLL-37 Complex\u003c\/b\u003e refers to the research-grade formulation of the human cathelicidin peptide, designed to investigate its interactions with nucleic acids and host membranes.\u003c\/p\u003e\n\u003cp data-path-to-node=\"18\"\u003eWhile native LL-37 is a potent antimicrobial, this specific formulation is often utilized to study the peptide's \"alarmin\" function—its ability to form complexes with self-DNA\/RNA. These complexes are critical triggers in autoimmune pathways (like psoriasis and lupus) and are potent stimulators of angiogenesis and wound healing via EGFR transactivation.\u003c\/p\u003e\n\u003chr data-path-to-node=\"19\"\u003e\n\u003ch3 data-path-to-node=\"20\"\u003e\u003cb data-path-to-node=\"20\" data-index-in-node=\"0\"\u003eMechanism of Action: The Nucleic Acid Carrier\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp data-path-to-node=\"21\"\u003eLL-37 acts as a molecular bridge between the innate immune system and host tissues.\u003c\/p\u003e\n\u003cul data-path-to-node=\"22\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"22,0,0\"\u003e\u003cb data-path-to-node=\"22,0,0\" data-index-in-node=\"0\"\u003eNucleic Acid Complexation:\u003c\/b\u003e The cationic peptide binds to anionic DNA and RNA released from damaged cells. It protects these nucleic acids from degradation and transports them into immune cells (pDCs), where they activate \u003cb data-path-to-node=\"22,0,0\" data-index-in-node=\"221\"\u003eTLR9\u003c\/b\u003e and \u003cb data-path-to-node=\"22,0,0\" data-index-in-node=\"230\"\u003eTLR7\u003c\/b\u003e, triggering interferon responses.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"22,1,0\"\u003e\u003cb data-path-to-node=\"22,1,0\" data-index-in-node=\"0\"\u003eEGFR Transactivation:\u003c\/b\u003e In epithelial tissues, LL-37 activates metalloproteinases (ADAMs) which cleave and release HB-EGF. This transactivates the \u003cb data-path-to-node=\"22,1,0\" data-index-in-node=\"145\"\u003eEpidermal Growth Factor Receptor (EGFR)\u003c\/b\u003e, driving keratinocyte migration and re-epithelialization.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"22,2,0\"\u003e\u003cb data-path-to-node=\"22,2,0\" data-index-in-node=\"0\"\u003eAngiogenesis:\u003c\/b\u003e Stimulates the proliferation of endothelial cells and the formation of new blood vessels via the FPR2 receptor and VEGF upregulation.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003chr data-path-to-node=\"23\"\u003e\n\u003ch3 data-path-to-node=\"24\"\u003e\u003cb data-path-to-node=\"24\" data-index-in-node=\"0\"\u003eKey Research Applications\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp data-path-to-node=\"25\"\u003e\u003cb data-path-to-node=\"25\" data-index-in-node=\"0\"\u003e1. Autoimmunity (Psoriasis\/Lupus)\u003c\/b\u003e The \"LL-37 Complex\" is the central autoantigen in psoriasis research. It converts inert self-DNA into a potent inflammatory signal, driving the Th17\/IFN-alpha axis.\u003c\/p\u003e\n\u003cp data-path-to-node=\"26\"\u003e\u003cb data-path-to-node=\"26\" data-index-in-node=\"0\"\u003e2. Chronic Wound Healing\u003c\/b\u003e Investigated for its ability to convert chronic, non-healing wounds into active repair sites by stimulating angiogenesis and neutralizing bacterial biofilms.\u003c\/p\u003e\n\u003cp data-path-to-node=\"27\"\u003e\u003cb data-path-to-node=\"27\" data-index-in-node=\"0\"\u003e3. Biofilm Disruption\u003c\/b\u003e Unlike antibiotics, LL-37 disrupts the physical integrity of bacterial biofilms (e.g., \u003ci data-path-to-node=\"27\" data-index-in-node=\"109\"\u003eP. aeruginosa\u003c\/i\u003e) at sub-lethal concentrations by downregulating quorum sensing systems.\u003c\/p\u003e\n\u003chr data-path-to-node=\"28\"\u003e\n\u003ch3 data-path-to-node=\"29\"\u003e\u003cb data-path-to-node=\"29\" data-index-in-node=\"0\"\u003eStorage \u0026amp; Handling\u003c\/b\u003e\u003c\/h3\u003e\n\u003cul data-path-to-node=\"30\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"30,0,0\"\u003e\u003cb data-path-to-node=\"30,0,0\" data-index-in-node=\"0\"\u003ePhysical State:\u003c\/b\u003e Lyophilized (Freeze-Dried) White Powder.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"30,1,0\"\u003e\u003cb data-path-to-node=\"30,1,0\" data-index-in-node=\"0\"\u003eStorage (Powder):\u003c\/b\u003e Store at -20°C (Freezer). Stable for up to 24 months.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"30,2,0\"\u003e\u003cb data-path-to-node=\"30,2,0\" data-index-in-node=\"0\"\u003eReconstitution:\u003c\/b\u003e\u003c\/p\u003e\n\u003cul data-path-to-node=\"30,2,1\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"30,2,1,0,0\"\u003e\u003cb data-path-to-node=\"30,2,1,0,0\" data-index-in-node=\"0\"\u003eSolvent:\u003c\/b\u003e Sterile Water (Endotoxin-Free). \u003cb data-path-to-node=\"30,2,1,0,0\" data-index-in-node=\"41\"\u003eAvoid high-salt buffers\u003c\/b\u003e initially to prevent aggregation.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"30,2,1,1,0\"\u003e\u003cb data-path-to-node=\"30,2,1,1,0\" data-index-in-node=\"0\"\u003eConcentration:\u003c\/b\u003e Reconstitute to \u0026gt;100 µg\/mL to minimize adsorption loss.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"30,3,0\"\u003e\u003cb data-path-to-node=\"30,3,0\" data-index-in-node=\"0\"\u003eStorage (Liquid):\u003c\/b\u003e Store at 4°C (Refrigerator). Use within 7 days.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003chr data-path-to-node=\"31\"\u003e\n\u003ch3 data-path-to-node=\"32\"\u003e\u003cb data-path-to-node=\"32\" data-index-in-node=\"0\"\u003eDisclaimer\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp data-path-to-node=\"33\"\u003e\u003cb data-path-to-node=\"33\" data-index-in-node=\"0\"\u003eFOR RESEARCH USE ONLY.\u003c\/b\u003e This product is a chemical compound intended strictly for laboratory research and development. It is not approved by the FDA for clinical use, diagnostics, or therapeutic procedures in humans or animals. The physiological and toxicological properties of this chemical have not been fully investigated.\u003c\/p\u003e","brand":"Peptagon","offers":[{"title":"Default Title","offer_id":47712362070230,"sku":"LL37-5","price":52.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0783\/3085\/5638\/files\/LL-37-Complex-5mg_2fc0c889-f93c-4f7c-8d3b-841ebe413934.png?v=1768507565"},{"product_id":"mgf-mechano-growth-factor-igf-1ec-research-peptide","title":"MGF Research Peptide – 5mg","description":"\u003ch4 data-path-to-node=\"13\"\u003e\u003cstrong\u003eMGF Peptide (Lyophilized)\u003c\/strong\u003e\u003c\/h4\u003e\n\u003cp data-path-to-node=\"14\"\u003e\u003cb data-path-to-node=\"14\" data-index-in-node=\"0\"\u003eSequence:\u003c\/b\u003e Tyr-Gln-Pro-Pro-Ser-Thr-Asn-Lys-Asn-Thr-Lys-Ser-Gln-Arg-Arg-Lys-Gly-Ser-Thr-Phe-Glu-Glu-Arg-Lys \u003cb data-path-to-node=\"14\" data-index-in-node=\"106\"\u003eFormat:\u003c\/b\u003e Sterile Lyophilized Powder (Vial) \u003cb data-path-to-node=\"14\" data-index-in-node=\"148\"\u003eIsoform:\u003c\/b\u003e IGF-1Ec C-Terminal Peptide \u003cb data-path-to-node=\"14\" data-index-in-node=\"184\"\u003ePurity:\u003c\/b\u003e \u0026gt;98% (HPLC) \u003cb data-path-to-node=\"14\" data-index-in-node=\"204\"\u003eContent:\u003c\/b\u003e 5mg per vial\u003c\/p\u003e\n\u003chr data-path-to-node=\"15\"\u003e\n\u003ch3 data-path-to-node=\"16\"\u003e\u003cb data-path-to-node=\"16\" data-index-in-node=\"0\"\u003eProduct Overview\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp data-path-to-node=\"17\"\u003e\u003cb data-path-to-node=\"17\" data-index-in-node=\"0\"\u003eMGF (Mechano Growth Factor)\u003c\/b\u003e is a splice variant of the IGF-1 gene (IGF-1Ec), naturally expressed in muscle tissue in response to mechanical stress and damage.\u003c\/p\u003e\n\u003cp data-path-to-node=\"18\"\u003eUnlike systemic IGF-1 which drives differentiation, MGF acts as a local \u003cb data-path-to-node=\"18\" data-index-in-node=\"72\"\u003estem cell activator\u003c\/b\u003e. It triggers the proliferation of quiescent satellite cells (muscle stem cells), expanding the pool of myoblasts available for repair. It is a critical research tool for investigating the initial phase of muscle regeneration, neuroprotection, and cardiac repair.\u003c\/p\u003e\n\u003chr data-path-to-node=\"19\"\u003e\n\u003ch3 data-path-to-node=\"20\"\u003e\u003cb data-path-to-node=\"20\" data-index-in-node=\"0\"\u003eMechanism of Action: The \"Activation\" Signal\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp data-path-to-node=\"21\"\u003eMGF operates via a unique signaling pathway distinct from the IGF-1 receptor.\u003c\/p\u003e\n\u003cul data-path-to-node=\"22\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"22,0,0\"\u003e\u003cb data-path-to-node=\"22,0,0\" data-index-in-node=\"0\"\u003eSatellite Cell Activation:\u003c\/b\u003e MGF drives quiescent satellite cells into the cell cycle (G0 -\u0026gt; G1), promoting rapid proliferation via the \u003cb data-path-to-node=\"22,0,0\" data-index-in-node=\"134\"\u003eMAPK\/ERK pathway\u003c\/b\u003e. This expands the \"raw material\" needed for tissue repair before differentiation begins.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"22,1,0\"\u003e\u003cb data-path-to-node=\"22,1,0\" data-index-in-node=\"0\"\u003eNeuroprotection:\u003c\/b\u003e Protects motor neurons and hippocampal neurons from ischemia and degeneration by stabilizing mitochondrial function and inhibiting caspase-3.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"22,2,0\"\u003e\u003cb data-path-to-node=\"22,2,0\" data-index-in-node=\"0\"\u003eCardioprotection:\u003c\/b\u003e Reduces cardiomyocyte apoptosis and recruits cardiac progenitor cells to sites of infarction (heart attack).\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003chr data-path-to-node=\"23\"\u003e\n\u003ch3 data-path-to-node=\"24\"\u003e\u003cb data-path-to-node=\"24\" data-index-in-node=\"0\"\u003eKey Research Applications\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp data-path-to-node=\"25\"\u003e\u003cb data-path-to-node=\"25\" data-index-in-node=\"0\"\u003e1. Musculoskeletal Regeneration\u003c\/b\u003e MGF is the primary signal for muscle repair.\u003c\/p\u003e\n\u003cul data-path-to-node=\"26\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"26,0,0\"\u003e\u003cb data-path-to-node=\"26,0,0\" data-index-in-node=\"0\"\u003eHyperplasia:\u003c\/b\u003e Promotes the division of muscle cells (hyperplasia) rather than just size increase (hypertrophy).\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"26,1,0\"\u003e\u003cb data-path-to-node=\"26,1,0\" data-index-in-node=\"0\"\u003eSarcopenia:\u003c\/b\u003e Research suggests that the age-related loss of muscle is due to a failure to express MGF; exogenous MGF can restore the proliferative capacity of aged muscle stem cells.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp data-path-to-node=\"27\"\u003e\u003cb data-path-to-node=\"27\" data-index-in-node=\"0\"\u003e2. Neurodegenerative Disease (ALS)\u003c\/b\u003e In mouse models of ALS (SOD1), MGF gene therapy significantly improved motor neuron survival compared to IGF-1, protecting neurons from \"suicide transport\" mechanisms.\u003c\/p\u003e\n\u003cp data-path-to-node=\"28\"\u003e\u003cb data-path-to-node=\"28\" data-index-in-node=\"0\"\u003e3. Ischemia \u0026amp; Stroke\u003c\/b\u003e Investigated for its ability to rescue neurons from delayed death following stroke. In gerbil models of brain ischemia, MGF treatment resulted in \u003cb data-path-to-node=\"28\" data-index-in-node=\"167\"\u003e74.5% survival\u003c\/b\u003e of vulnerable hippocampal neurons compared to near-total loss in controls.\u003c\/p\u003e\n\u003chr data-path-to-node=\"29\"\u003e\n\u003ch3 data-path-to-node=\"30\"\u003e\u003cb data-path-to-node=\"30\" data-index-in-node=\"0\"\u003eImportant Note: MGF vs. PEG-MGF\u003c\/b\u003e\u003c\/h3\u003e\n\u003cul data-path-to-node=\"31\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"31,0,0\"\u003e\u003cb data-path-to-node=\"31,0,0\" data-index-in-node=\"0\"\u003eMGF (This Product):\u003c\/b\u003e Native sequence. Short half-life (~5-30 mins). Ideal for local administration mimicking the body's acute stress response.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"31,1,0\"\u003e\u003cb data-path-to-node=\"31,1,0\" data-index-in-node=\"0\"\u003ePEG-MGF:\u003c\/b\u003e PEGylated variant. Long half-life (days). Systemic distribution.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"31,2,0\"\u003e\u003ci data-path-to-node=\"31,2,0\" data-index-in-node=\"0\"\u003eThis listing is for the Native MGF peptide.\u003c\/i\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003chr data-path-to-node=\"32\"\u003e\n\u003ch3 data-path-to-node=\"33\"\u003e\u003cb data-path-to-node=\"33\" data-index-in-node=\"0\"\u003eStorage \u0026amp; Handling\u003c\/b\u003e\u003c\/h3\u003e\n\u003cul data-path-to-node=\"34\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"34,0,0\"\u003e\u003cb data-path-to-node=\"34,0,0\" data-index-in-node=\"0\"\u003ePhysical State:\u003c\/b\u003e Lyophilized (Freeze-Dried) White Powder.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"34,1,0\"\u003e\u003cb data-path-to-node=\"34,1,0\" data-index-in-node=\"0\"\u003eStorage (Powder):\u003c\/b\u003e Store at -20°C (Freezer). Stable for up to 12 months.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"34,2,0\"\u003e\u003cb data-path-to-node=\"34,2,0\" data-index-in-node=\"0\"\u003eReconstitution:\u003c\/b\u003e\u003c\/p\u003e\n\u003cul data-path-to-node=\"34,2,1\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"34,2,1,0,0\"\u003e\u003cb data-path-to-node=\"34,2,1,0,0\" data-index-in-node=\"0\"\u003eSolvent:\u003c\/b\u003e \u003cb data-path-to-node=\"34,2,1,0,0\" data-index-in-node=\"9\"\u003eSterile 0.1% Acetic Acid\u003c\/b\u003e is recommended to ensure full dissolution of basic residues, followed by dilution with sterile water or saline.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"34,2,1,1,0\"\u003e\u003cb data-path-to-node=\"34,2,1,1,0\" data-index-in-node=\"0\"\u003eStability:\u003c\/b\u003e Highly unstable once reconstituted. Use immediately or freeze single-use aliquots.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"34,3,0\"\u003e\u003cb data-path-to-node=\"34,3,0\" data-index-in-node=\"0\"\u003eStorage (Liquid):\u003c\/b\u003e Store at 4°C. \u003cb data-path-to-node=\"34,3,0\" data-index-in-node=\"32\"\u003eDo not freeze-thaw repeatedly.\u003c\/b\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003chr data-path-to-node=\"35\"\u003e\n\u003ch3 data-path-to-node=\"36\"\u003e\u003cb data-path-to-node=\"36\" data-index-in-node=\"0\"\u003eDisclaimer\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp data-path-to-node=\"37\"\u003e\u003cb data-path-to-node=\"37\" data-index-in-node=\"0\"\u003eFOR RESEARCH USE ONLY.\u003c\/b\u003e This product is a chemical compound intended strictly for laboratory research and development. It is not approved by the FDA for clinical use, diagnostics, or therapeutic procedures in humans or animals. The physiological and toxicological properties of this chemical have not been fully investigated.\u003c\/p\u003e","brand":"Peptagon","offers":[{"title":"Default Title","offer_id":47712362528982,"sku":"MGF-5","price":73.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0783\/3085\/5638\/files\/MGF-_IGF-1Ec_-5mg.png?v=1768509217"},{"product_id":"mots-c-mitochondrial-derived-research-peptide","title":"MOTS-c Research Peptide – 10mg","description":"\u003ch4 data-path-to-node=\"13\"\u003e\u003cstrong\u003eMOTS-c Peptide (Lyophilized)\u003c\/strong\u003e\u003c\/h4\u003e\n\u003cp data-path-to-node=\"14\"\u003e\u003cb data-path-to-node=\"14\" data-index-in-node=\"0\"\u003eSequence:\u003c\/b\u003e Met-Arg-Trp-Gln-Glu-Met-Gly-Tyr-Ile-Phe-Tyr-Pro-Arg-Lys-Leu-Arg \u003cb data-path-to-node=\"14\" data-index-in-node=\"74\"\u003eFormat:\u003c\/b\u003e Sterile Lyophilized Powder (Vial) \u003cb data-path-to-node=\"14\" data-index-in-node=\"116\"\u003eOrigin:\u003c\/b\u003e Mitochondrial-Derived Peptide (12S rRNA) \u003cb data-path-to-node=\"14\" data-index-in-node=\"165\"\u003ePurity:\u003c\/b\u003e \u0026gt;98% (HPLC) \u003cb data-path-to-node=\"14\" data-index-in-node=\"185\"\u003eContent:\u003c\/b\u003e 10mg per vial\u003c\/p\u003e\n\u003chr data-path-to-node=\"15\"\u003e\n\u003ch3 data-path-to-node=\"16\"\u003e\u003cb data-path-to-node=\"16\" data-index-in-node=\"0\"\u003eProduct Overview\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp data-path-to-node=\"17\"\u003e\u003cb data-path-to-node=\"17\" data-index-in-node=\"0\"\u003eMOTS-c\u003c\/b\u003e (Mitochondrial Open Reading Frame of the 12S rRNA-c) is a 16-amino acid peptide encoded within the mitochondrial genome. It represents a breakthrough in understanding how mitochondria communicate with the rest of the cell.\u003c\/p\u003e\n\u003cp data-path-to-node=\"18\"\u003eUnlike traditional hormones, MOTS-c acts as a \u003cb data-path-to-node=\"18\" data-index-in-node=\"46\"\u003emitochondrial signal\u003c\/b\u003e, translocating to the nucleus to regulate gene expression in response to metabolic stress. It is extensively researched for its ability to mimic the physiological effects of exercise, regulate insulin sensitivity, and promote healthy aging via the AMPK pathway.\u003c\/p\u003e\n\u003chr data-path-to-node=\"19\"\u003e\n\u003ch3 data-path-to-node=\"20\"\u003e\u003cb data-path-to-node=\"20\" data-index-in-node=\"0\"\u003eMechanism of Action: The Mitonuclear Signal\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp data-path-to-node=\"21\"\u003eMOTS-c functions via a unique dual mechanism involving metabolic enzyme inhibition and nuclear gene regulation.\u003c\/p\u003e\n\u003cul data-path-to-node=\"22\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"22,0,0\"\u003e\u003cb data-path-to-node=\"22,0,0\" data-index-in-node=\"0\"\u003eFolate-AMPK Axis:\u003c\/b\u003e It inhibits the enzyme ATIC in the folate cycle, leading to an accumulation of AICAR. This activates \u003cb data-path-to-node=\"22,0,0\" data-index-in-node=\"119\"\u003eAMPK\u003c\/b\u003e, the cell's master metabolic switch, driving fatty acid oxidation and glucose uptake without the need for insulin.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"22,1,0\"\u003e\u003cb data-path-to-node=\"22,1,0\" data-index-in-node=\"0\"\u003eNuclear Translocation:\u003c\/b\u003e Under stress, MOTS-c moves into the nucleus where it binds to \u003cb data-path-to-node=\"22,1,0\" data-index-in-node=\"85\"\u003eNRF2\u003c\/b\u003e and Antioxidant Response Elements (ARE), upregulating cytoprotective genes to defend against oxidative stress.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"22,2,0\"\u003e\u003cb data-path-to-node=\"22,2,0\" data-index-in-node=\"0\"\u003eMyostatin Inhibition:\u003c\/b\u003e Downregulates myostatin expression via the AKT-FOXO1 axis, preventing muscle atrophy.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003chr data-path-to-node=\"23\"\u003e\n\u003ch3 data-path-to-node=\"24\"\u003e\u003cb data-path-to-node=\"24\" data-index-in-node=\"0\"\u003eKey Research Applications\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp data-path-to-node=\"25\"\u003e\u003cb data-path-to-node=\"25\" data-index-in-node=\"0\"\u003e1. Metabolic Regulation (Obesity \u0026amp; Diabetes)\u003c\/b\u003e MOTS-c is a potent insulin sensitizer. In high-fat diet models, it prevents diet-induced obesity and reverses insulin resistance by promoting GLUT4 translocation and \"browning\" of white adipose tissue (thermogenesis).\u003c\/p\u003e\n\u003cp data-path-to-node=\"26\"\u003e\u003cb data-path-to-node=\"26\" data-index-in-node=\"0\"\u003e2. Exercise Mimicry \u0026amp; Performance\u003c\/b\u003e Known as an \"exercise mimetic,\" MOTS-c administration significantly improves physical performance. In aged mice, treatment \u003cb data-path-to-node=\"26\" data-index-in-node=\"157\"\u003edoubled running capacity\u003c\/b\u003e and improved grip strength, effectively rejuvenating skeletal muscle function.\u003c\/p\u003e\n\u003cp data-path-to-node=\"27\"\u003e\u003cb data-path-to-node=\"27\" data-index-in-node=\"0\"\u003e3. Gerontology (Anti-Aging)\u003c\/b\u003e Research (Reynolds et al.) indicates that late-life administration of MOTS-c can extend healthspan and lifespan. It restores the communication between mitochondria and the nucleus, which typically degrades with age, reducing frailty and metabolic decline.\u003c\/p\u003e\n\u003cp data-path-to-node=\"28\"\u003e\u003cb data-path-to-node=\"28\" data-index-in-node=\"0\"\u003e4. Osteobiology\u003c\/b\u003e Promotes bone formation (osteoblastogenesis) via the TGF-beta\/Smad pathway while inhibiting bone breakdown (osteoclasts), offering a potential avenue for osteoporosis research.\u003c\/p\u003e\n\u003chr data-path-to-node=\"29\"\u003e\n\u003ch3 data-path-to-node=\"30\"\u003e\u003cb data-path-to-node=\"30\" data-index-in-node=\"0\"\u003eStorage \u0026amp; Handling\u003c\/b\u003e\u003c\/h3\u003e\n\u003cul data-path-to-node=\"31\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"31,0,0\"\u003e\u003cb data-path-to-node=\"31,0,0\" data-index-in-node=\"0\"\u003ePhysical State:\u003c\/b\u003e Lyophilized (Freeze-Dried) White Powder.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"31,1,0\"\u003e\u003cb data-path-to-node=\"31,1,0\" data-index-in-node=\"0\"\u003eStorage (Powder):\u003c\/b\u003e Store at -20°C (Freezer). Stable for up to 24 months.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"31,2,0\"\u003e\u003cb data-path-to-node=\"31,2,0\" data-index-in-node=\"0\"\u003eReconstitution:\u003c\/b\u003e\u003c\/p\u003e\n\u003cul data-path-to-node=\"31,2,1\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"31,2,1,0,0\"\u003e\u003cb data-path-to-node=\"31,2,1,0,0\" data-index-in-node=\"0\"\u003eSolvent:\u003c\/b\u003e Sterile Water or Bacteriostatic Water.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"31,2,1,1,0\"\u003e\u003cb data-path-to-node=\"31,2,1,1,0\" data-index-in-node=\"0\"\u003eSolubility:\u003c\/b\u003e Soluble in water.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"31,3,0\"\u003e\u003cb data-path-to-node=\"31,3,0\" data-index-in-node=\"0\"\u003eStorage (Liquid):\u003c\/b\u003e Store at 4°C (Refrigerator). Use within 14 days. \u003cb data-path-to-node=\"31,3,0\" data-index-in-node=\"67\"\u003eDo not freeze-thaw repeatedly.\u003c\/b\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003chr data-path-to-node=\"32\"\u003e\n\u003ch3 data-path-to-node=\"33\"\u003e\u003cb data-path-to-node=\"33\" data-index-in-node=\"0\"\u003eDisclaimer\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp data-path-to-node=\"34\"\u003e\u003cb data-path-to-node=\"34\" data-index-in-node=\"0\"\u003eFOR RESEARCH USE ONLY.\u003c\/b\u003e This product is a chemical compound intended strictly for laboratory research and development. It is not approved by the FDA for clinical use, diagnostics, or therapeutic procedures in humans or animals. The physiological and toxicological properties of this chemical have not been fully investigated.\u003c\/p\u003e","brand":"Peptagon","offers":[{"title":"Default Title","offer_id":47712368034006,"sku":"MOTSC-10","price":36.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0783\/3085\/5638\/files\/MOTs-C-10mg.png?v=1768507596"},{"product_id":"melanotan-ii-mt-ii-melanocortin-research-peptide","title":"Melanotan II Research Peptide – 10mg","description":"\u003ch4 data-path-to-node=\"13\"\u003e\u003cstrong\u003eMelanotan II Peptide (Lyophilized)\u003c\/strong\u003e\u003c\/h4\u003e\n\u003cp data-path-to-node=\"14\"\u003e\u003cb data-path-to-node=\"14\" data-index-in-node=\"0\"\u003eSequence:\u003c\/b\u003e Ac-Nle-Asp-His-D-Phe-Arg-Trp-Lys-NH2 (Cyclic Lactam) \u003cb data-path-to-node=\"14\" data-index-in-node=\"63\"\u003eFormat:\u003c\/b\u003e Sterile Lyophilized Powder (Vial) \u003cb data-path-to-node=\"14\" data-index-in-node=\"105\"\u003eClass:\u003c\/b\u003e Melanocortin Receptor Agonist \u003cb data-path-to-node=\"14\" data-index-in-node=\"142\"\u003ePurity:\u003c\/b\u003e \u0026gt;98% (HPLC) \u003cb data-path-to-node=\"14\" data-index-in-node=\"162\"\u003eContent:\u003c\/b\u003e 10mg per vial\u003c\/p\u003e\n\u003chr data-path-to-node=\"15\"\u003e\n\u003ch3 data-path-to-node=\"16\"\u003e\u003cb data-path-to-node=\"16\" data-index-in-node=\"0\"\u003eProduct Overview\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp data-path-to-node=\"17\"\u003e\u003cb data-path-to-node=\"17\" data-index-in-node=\"0\"\u003eMelanotan II (MT-II)\u003c\/b\u003e is a synthetic cyclic heptapeptide and a \"super-agonist\" of the melanocortin receptor system. It was originally developed as a tanning agent but is widely researched for its pleiotropic effects on sexual function and metabolism.\u003c\/p\u003e\n\u003cp data-path-to-node=\"18\"\u003eUnlike native alpha-MSH, which degrades in minutes, MT-II incorporates a lactam bridge and D-amino acids that lock it into a bioactive conformation, making it highly resistant to enzymatic breakdown. It potently activates MC1R (pigmentation), MC3R\/MC4R (sexual desire\/metabolism), and MC5R.\u003c\/p\u003e\n\u003chr data-path-to-node=\"19\"\u003e\n\u003ch3 data-path-to-node=\"20\"\u003e\u003cb data-path-to-node=\"20\" data-index-in-node=\"0\"\u003eMechanism of Action: The Pan-Agonist\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp data-path-to-node=\"21\"\u003eMT-II operates via multiple G-protein coupled receptors to drive diverse physiological responses.\u003c\/p\u003e\n\u003cul data-path-to-node=\"22\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"22,0,0\"\u003e\u003cb data-path-to-node=\"22,0,0\" data-index-in-node=\"0\"\u003eMC1R Activation (Pigmentation):\u003c\/b\u003e Binds to receptors on melanocytes, increasing intracellular cAMP. This upregulates MITF and Tyrosinase, driving the synthesis of \u003cb data-path-to-node=\"22,0,0\" data-index-in-node=\"161\"\u003eeumelanin\u003c\/b\u003e (photoprotective brown pigment) over pheomelanin.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"22,1,0\"\u003e\u003cb data-path-to-node=\"22,1,0\" data-index-in-node=\"0\"\u003eMC4R Activation (Libido):\u003c\/b\u003e Acts centrally in the hypothalamus (PVN\/MPOA) to trigger sexual desire and erectile function via dopamine and nitric oxide pathways. It is effective even in models of nerve damage.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"22,2,0\"\u003e\u003cb data-path-to-node=\"22,2,0\" data-index-in-node=\"0\"\u003eMetabolic Regulation:\u003c\/b\u003e Activation of hypothalamic MC4R suppresses appetite (anorexigenic) and increases energy expenditure via sympathetic nervous system stimulation of brown fat thermogenesis.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003chr data-path-to-node=\"23\"\u003e\n\u003ch3 data-path-to-node=\"24\"\u003e\u003cb data-path-to-node=\"24\" data-index-in-node=\"0\"\u003eKey Research Applications\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp data-path-to-node=\"25\"\u003e\u003cb data-path-to-node=\"25\" data-index-in-node=\"0\"\u003e1. Photoprotection \u0026amp; Tanning\u003c\/b\u003e MT-II is the benchmark for stimulating tanning without UV exposure.\u003c\/p\u003e\n\u003cul data-path-to-node=\"26\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"26,0,0\"\u003e\u003cb data-path-to-node=\"26,0,0\" data-index-in-node=\"0\"\u003eEumelanin Synthesis:\u003c\/b\u003e Research confirms it increases melanin density, providing biological protection against UV radiation (distinct from sunless tanners that only dye the skin).\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp data-path-to-node=\"27\"\u003e\u003cb data-path-to-node=\"27\" data-index-in-node=\"0\"\u003e2. Sexual Function (ED \u0026amp; Libido)\u003c\/b\u003e Investigated as a potent initiator of sexual desire and erection.\u003c\/p\u003e\n\u003cul data-path-to-node=\"28\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"28,0,0\"\u003e\u003cb data-path-to-node=\"28,0,0\" data-index-in-node=\"0\"\u003eCentral Mechanism:\u003c\/b\u003e Unlike PDE5 inhibitors (Viagra) which act on blood flow, MT-II acts on the brain to increase \u003ci data-path-to-node=\"28,0,0\" data-index-in-node=\"112\"\u003edesire\u003c\/i\u003e and \u003ci data-path-to-node=\"28,0,0\" data-index-in-node=\"123\"\u003earousal\u003c\/i\u003e. Clinical trials showed erectile response in \u003cb data-path-to-node=\"28,0,0\" data-index-in-node=\"176\"\u003e85%\u003c\/b\u003e of men with ED.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp data-path-to-node=\"29\"\u003e\u003cb data-path-to-node=\"29\" data-index-in-node=\"0\"\u003e3. Metabolism \u0026amp; Weight Loss\u003c\/b\u003e\u003c\/p\u003e\n\u003cul data-path-to-node=\"30\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"30,0,0\"\u003e\u003cb data-path-to-node=\"30,0,0\" data-index-in-node=\"0\"\u003eFat Loss:\u003c\/b\u003e In animal models, MT-II causes significant weight loss by reducing food intake and preferentially burning visceral fat, even in diet-induced obesity.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003chr data-path-to-node=\"31\"\u003e\n\u003ch3 data-path-to-node=\"32\"\u003e\u003cb data-path-to-node=\"32\" data-index-in-node=\"0\"\u003eStorage \u0026amp; Handling\u003c\/b\u003e\u003c\/h3\u003e\n\u003cul data-path-to-node=\"33\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"33,0,0\"\u003e\u003cb data-path-to-node=\"33,0,0\" data-index-in-node=\"0\"\u003ePhysical State:\u003c\/b\u003e Lyophilized (Freeze-Dried) White Powder.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"33,1,0\"\u003e\u003cb data-path-to-node=\"33,1,0\" data-index-in-node=\"0\"\u003eStorage (Powder):\u003c\/b\u003e Store at -20°C (Freezer). Stable for up to 12 months.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"33,2,0\"\u003e\u003cb data-path-to-node=\"33,2,0\" data-index-in-node=\"0\"\u003eReconstitution:\u003c\/b\u003e\u003c\/p\u003e\n\u003cul data-path-to-node=\"33,2,1\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"33,2,1,0,0\"\u003e\u003cb data-path-to-node=\"33,2,1,0,0\" data-index-in-node=\"0\"\u003eSolvent:\u003c\/b\u003e Bacteriostatic Water or Sterile Saline.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"33,2,1,1,0\"\u003e\u003cb data-path-to-node=\"33,2,1,1,0\" data-index-in-node=\"0\"\u003eSolubility:\u003c\/b\u003e Highly soluble.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"33,3,0\"\u003e\u003cb data-path-to-node=\"33,3,0\" data-index-in-node=\"0\"\u003eStorage (Liquid):\u003c\/b\u003e Store at 4°C (Refrigerator). Use within 3-4 weeks to prevent degradation. \u003cb data-path-to-node=\"33,3,0\" data-index-in-node=\"92\"\u003eAvoid freeze-thaw cycles.\u003c\/b\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003chr data-path-to-node=\"34\"\u003e\n\u003ch3 data-path-to-node=\"35\"\u003e\u003cb data-path-to-node=\"35\" data-index-in-node=\"0\"\u003eDisclaimer\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp data-path-to-node=\"36\"\u003e\u003cb data-path-to-node=\"36\" data-index-in-node=\"0\"\u003eFOR RESEARCH USE ONLY.\u003c\/b\u003e This product is a chemical compound intended strictly for laboratory research and development. It is not approved by the FDA for clinical use, diagnostics, or therapeutic procedures in humans or animals. The physiological and toxicological properties of this chemical have not been fully investigated.\u003c\/p\u003e","brand":"Peptagon","offers":[{"title":"Default Title","offer_id":47712368066774,"sku":"MTII-10","price":32.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0783\/3085\/5638\/files\/Melanotan-II-10mg.png?v=1768511032"},{"product_id":"nad-nicotinamide-adenine-dinucleotide-1000mg-research-vial","title":"NAD+ Research Vial – 1000mg – 5mL","description":"\u003ch4 data-path-to-node=\"13\"\u003e\u003cstrong\u003eNAD+ (Nicotinamide Adenine Dinucleotide) 1000mg\u003c\/strong\u003e\u003c\/h4\u003e\n\u003cp data-path-to-node=\"14\"\u003e\u003cb data-path-to-node=\"14\" data-index-in-node=\"0\"\u003eConcentration:\u003c\/b\u003e 200 mg\/mL (1000mg total in 5mL) \u003cb data-path-to-node=\"14\" data-index-in-node=\"47\"\u003eFormat:\u003c\/b\u003e Sterile Aqueous Solution (High-Load) \u003cb data-path-to-node=\"14\" data-index-in-node=\"92\"\u003eOrigin:\u003c\/b\u003e Biofermented (Yeast-Derived, Endotoxin-Free) \u003cb data-path-to-node=\"14\" data-index-in-node=\"145\"\u003ePurity:\u003c\/b\u003e \u0026gt;99% (Pharmaceutical Grade) \u003cb data-path-to-node=\"14\" data-index-in-node=\"181\"\u003epH:\u003c\/b\u003e Neutral-Buffered (Optimized for Stability)\u003cbr\u003e\u003c\/p\u003e\n\u003ch3 data-path-to-node=\"17\"\u003e\u003cb data-path-to-node=\"17\" data-index-in-node=\"0\"\u003eProduct Overview\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp data-path-to-node=\"18\"\u003e\u003cb data-path-to-node=\"18\" data-index-in-node=\"0\"\u003eNAD+ (Nicotinamide Adenine Dinucleotide)\u003c\/b\u003e is the central coenzyme of metabolism, essential for converting nutrients into energy (ATP). This \u003cb data-path-to-node=\"18\" data-index-in-node=\"139\"\u003e1000mg Biofermented Formulation\u003c\/b\u003e represents the pinnacle of solubility engineering, achieving a concentration of \u003cb data-path-to-node=\"18\" data-index-in-node=\"251\"\u003e200 mg\/mL\u003c\/b\u003e.\u003c\/p\u003e\n\u003cp data-path-to-node=\"19\"\u003eProduced via metabolic engineering of \u003ci data-path-to-node=\"19\" data-index-in-node=\"38\"\u003eSaccharomyces cerevisiae\u003c\/i\u003e, this formulation ensures stereochemical purity (active β-anomer only) and is rigorously purified to remove endotoxins (\u0026lt;0.35 EU\/mg). It is designed for high-dose research applications where \"flooding\" the metabolic salvage pathway is required to overcome rate-limiting enzymes.\u003c\/p\u003e\n\u003chr data-path-to-node=\"20\"\u003e\n\u003ch3 data-path-to-node=\"21\"\u003e\u003cb data-path-to-node=\"21\" data-index-in-node=\"0\"\u003eMechanism of Action: The Metabolic Master Switch\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp data-path-to-node=\"22\"\u003eNAD+ operates as both a metabolic cofactor and a signaling molecule.\u003c\/p\u003e\n\u003cul data-path-to-node=\"23\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"23,0,0\"\u003e\u003cb data-path-to-node=\"23,0,0\" data-index-in-node=\"0\"\u003eSirtuin Activation:\u003c\/b\u003e It is the obligatory substrate for Sirtuins (SIRT1-7), the \"longevity genes.\" High-dose NAD+ activates SIRT1, leading to the deacetylation of FOXO3a (stress resistance) and PGC-1alpha (mitochondrial biogenesis).\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"23,1,0\"\u003e\u003cb data-path-to-node=\"23,1,0\" data-index-in-node=\"0\"\u003eMitochondrial Rescue:\u003c\/b\u003e Reverses \"pseudohypoxia\" (the false signal of low oxygen) in aging cells, restoring mitochondrial ATP production and electron transport chain efficiency.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"23,2,0\"\u003e\u003cb data-path-to-node=\"23,2,0\" data-index-in-node=\"0\"\u003eNeuroprotection (SARM1):\u003c\/b\u003e Inhibits the enzyme SARM1. In injured axons, high levels of NAD+ prevent SARM1 activation, halting axon degeneration and preserving neural architecture.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003chr data-path-to-node=\"24\"\u003e\n\u003ch3 data-path-to-node=\"25\"\u003e\u003cb data-path-to-node=\"25\" data-index-in-node=\"0\"\u003eKey Research Applications\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp data-path-to-node=\"26\"\u003e\u003cb data-path-to-node=\"26\" data-index-in-node=\"0\"\u003e1. Addiction \u0026amp; Neurotransmitter Restoration\u003c\/b\u003e High-dose NAD+ is the cornerstone of \"Brain Restoration\" research. It replenishes mitochondrial energy in neurons and re-regulates the circadian clock (via SIRT1\/CLOCK), normalizing \u003cb data-path-to-node=\"26\" data-index-in-node=\"226\"\u003edopamine synthesis\u003c\/b\u003e in the nucleus accumbens to reduce cravings and withdrawal anxiety.\u003c\/p\u003e\n\u003cp data-path-to-node=\"27\"\u003e\u003cb data-path-to-node=\"27\" data-index-in-node=\"0\"\u003e2. Anti-Aging \u0026amp; Metabolic Health\u003c\/b\u003e Investigated for its ability to mimic caloric restriction. By activating AMPK and SIRT1, it corrects dyslipidemia, improves insulin sensitivity, and promotes healthy DNA repair via PARP enzymes.\u003c\/p\u003e\n\u003cp data-path-to-node=\"28\"\u003e\u003cb data-path-to-node=\"28\" data-index-in-node=\"0\"\u003e3. Ischemia \u0026amp; Cytoprotection\u003c\/b\u003e In models of heart attack (ischemia-reperfusion), NAD+ administration reduced infarct size by up to \u003cb data-path-to-node=\"28\" data-index-in-node=\"129\"\u003e85%\u003c\/b\u003e. It salvages tissue viability by maintaining ATP levels during critical stress.\u003c\/p\u003e\n\u003chr data-path-to-node=\"29\"\u003e\n\u003ch3 data-path-to-node=\"30\"\u003e\u003cb data-path-to-node=\"30\" data-index-in-node=\"0\"\u003eStorage \u0026amp; Handling\u003c\/b\u003e\u003c\/h3\u003e\n\u003cul data-path-to-node=\"31\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"31,0,0\"\u003e\u003cb data-path-to-node=\"31,0,0\" data-index-in-node=\"0\"\u003ePhysical State:\u003c\/b\u003e Clear to slightly yellow liquid.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"31,1,0\"\u003e\u003cb data-path-to-node=\"31,1,0\" data-index-in-node=\"0\"\u003eStorage:\u003c\/b\u003e \u003cb data-path-to-node=\"31,1,0\" data-index-in-node=\"9\"\u003eMUST BE REFRIGERATED (2-8°C).\u003c\/b\u003e Do not freeze.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"31,2,0\"\u003e\u003cb data-path-to-node=\"31,2,0\" data-index-in-node=\"0\"\u003eStability:\u003c\/b\u003e This high-concentration formulation is thermodynamically stable at cold temperatures. Room temperature storage will accelerate degradation into Nicotinamide (an inhibitor).\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003chr data-path-to-node=\"32\"\u003e\n\u003ch3 data-path-to-node=\"33\"\u003e\u003cb data-path-to-node=\"33\" data-index-in-node=\"0\"\u003eDisclaimer\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp data-path-to-node=\"34\"\u003e\u003cb data-path-to-node=\"34\" data-index-in-node=\"0\"\u003eFOR RESEARCH USE ONLY.\u003c\/b\u003e This product is a chemical compound intended strictly for laboratory research and development. It is not approved by the FDA for clinical use, diagnostics, or therapeutic procedures in humans or animals. The physiological and toxicological properties of this chemical have not been fully investigated.\u003c\/p\u003e","brand":"Peptagon","offers":[{"title":"Default Title","offer_id":47712407060694,"sku":"NAD-BF-1000","price":72.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0783\/3085\/5638\/files\/NAD.png?v=1776955277"},{"product_id":"pe-22-28-trek-1-research-peptide","title":"PE-22-28 Research Peptide – 10mg","description":"\u003ch4 data-path-to-node=\"13\"\u003e\u003cstrong\u003ePE-22-28 Peptide (Lyophilized)\u003c\/strong\u003e\u003c\/h4\u003e\n\u003cp data-path-to-node=\"14\"\u003e\u003cb data-path-to-node=\"14\" data-index-in-node=\"0\"\u003eSequence:\u003c\/b\u003e Gly-Val-Ser-Trp-Gly-Leu-Arg (GVSWGLR) \u003cb data-path-to-node=\"14\" data-index-in-node=\"48\"\u003eFormat:\u003c\/b\u003e Sterile Lyophilized Powder (Vial) \u003cb data-path-to-node=\"14\" data-index-in-node=\"90\"\u003eTarget:\u003c\/b\u003e TREK-1 Potassium Channel Inhibitor \u003cb data-path-to-node=\"14\" data-index-in-node=\"133\"\u003ePurity:\u003c\/b\u003e \u0026gt;98% (HPLC) \u003cb data-path-to-node=\"14\" data-index-in-node=\"153\"\u003eContent:\u003c\/b\u003e 10mg per vial\u003c\/p\u003e\n\u003chr data-path-to-node=\"15\"\u003e\n\u003ch3 data-path-to-node=\"16\"\u003e\u003cb data-path-to-node=\"16\" data-index-in-node=\"0\"\u003eProduct Overview\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp data-path-to-node=\"17\"\u003e\u003cb data-path-to-node=\"17\" data-index-in-node=\"0\"\u003ePE-22-28\u003c\/b\u003e is a synthetic heptapeptide derived from the endogenous protein Spadin (Sortilin). It is a highly potent inhibitor of the \u003cb data-path-to-node=\"17\" data-index-in-node=\"131\"\u003eTREK-1 (TWIK-related potassium channel-1)\u003c\/b\u003e ion channel.\u003c\/p\u003e\n\u003cp data-path-to-node=\"18\"\u003eUnlike traditional antidepressants that target serotonin reuptake (SSRIs), PE-22-28 works downstream by modulating neuronal excitability directly. It acts as a \"neuroplasticity catalyst,\" promoting the growth of new neurons (neurogenesis) and synapses (synaptogenesis) in the hippocampus and prefrontal cortex. It is investigated for its ability to produce rapid antidepressant effects in \u003cb data-path-to-node=\"18\" data-index-in-node=\"389\"\u003e4 days\u003c\/b\u003e, compared to the 3-4 weeks required for standard therapies.\u003c\/p\u003e\n\u003chr data-path-to-node=\"19\"\u003e\n\u003ch3 data-path-to-node=\"20\"\u003e\u003cb data-path-to-node=\"20\" data-index-in-node=\"0\"\u003eMechanism of Action: The TREK-1 Blockade\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp data-path-to-node=\"21\"\u003ePE-22-28 functions by blocking the background \"leak\" current of potassium ions in neurons.\u003c\/p\u003e\n\u003cul data-path-to-node=\"22\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"22,0,0\"\u003e\u003cb data-path-to-node=\"22,0,0\" data-index-in-node=\"0\"\u003eDepolarization:\u003c\/b\u003e By inhibiting TREK-1, it slightly depolarizes neurons, making them more excitable and ready to fire. This increases the activity of serotonergic neurons in the Dorsal Raphe Nucleus without the lag of autoreceptor desensitization.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"22,1,0\"\u003e\u003cb data-path-to-node=\"22,1,0\" data-index-in-node=\"0\"\u003eNeurotrophic Signaling:\u003c\/b\u003e The depolarization triggers calcium influx, activating the \u003cb data-path-to-node=\"22,1,0\" data-index-in-node=\"83\"\u003eCREB\u003c\/b\u003e transcription factor. This leads to the rapid expression of \u003cb data-path-to-node=\"22,1,0\" data-index-in-node=\"148\"\u003eBDNF (Brain-Derived Neurotrophic Factor)\u003c\/b\u003e, the key driver of neuronal growth and survival.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"22,2,0\"\u003e\u003cb data-path-to-node=\"22,2,0\" data-index-in-node=\"0\"\u003eSynaptogenesis:\u003c\/b\u003e Increases the density of \u003cb data-path-to-node=\"22,2,0\" data-index-in-node=\"41\"\u003ePSD-95\u003c\/b\u003e, a marker of mature, functional synapses, restoring connectivity in depressed or damaged brain circuits.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003chr data-path-to-node=\"23\"\u003e\n\u003ch3 data-path-to-node=\"24\"\u003e\u003cb data-path-to-node=\"24\" data-index-in-node=\"0\"\u003eKey Research Applications\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp data-path-to-node=\"25\"\u003e\u003cb data-path-to-node=\"25\" data-index-in-node=\"0\"\u003e1. Rapid-Acting Antidepressant\u003c\/b\u003e PE-22-28 is the benchmark for researching rapid mood recovery. Preclinical studies show it reduces immobility (depression-like behavior) and anxiety within \u003cb data-path-to-node=\"25\" data-index-in-node=\"187\"\u003e4 days\u003c\/b\u003e, offering a potential alternative to slow-acting monoaminergic drugs.\u003c\/p\u003e\n\u003cp data-path-to-node=\"26\"\u003e\u003cb data-path-to-node=\"26\" data-index-in-node=\"0\"\u003e2. Stroke Recovery \u0026amp; Neuroprotection\u003c\/b\u003e Investigated for its biphasic role in stroke:\u003c\/p\u003e\n\u003cul data-path-to-node=\"27\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"27,0,0\"\u003e\u003cb data-path-to-node=\"27,0,0\" data-index-in-node=\"0\"\u003eAcute Phase:\u003c\/b\u003e Low doses may offer neuroprotection.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"27,1,0\"\u003e\u003cb data-path-to-node=\"27,1,0\" data-index-in-node=\"0\"\u003eChronic Phase:\u003c\/b\u003e High doses stimulate neurogenesis, improving motor coordination and memory recovery weeks after ischemic injury.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp data-path-to-node=\"28\"\u003e\u003cb data-path-to-node=\"28\" data-index-in-node=\"0\"\u003e3. Cognitive Enhancement\u003c\/b\u003e By promoting synaptic plasticity and hippocampal neurogenesis, PE-22-28 is studied for its ability to improve spatial memory and learning capabilities in models of cognitive decline.\u003c\/p\u003e\n\u003chr data-path-to-node=\"29\"\u003e\n\u003ch3 data-path-to-node=\"30\"\u003e\u003cb data-path-to-node=\"30\" data-index-in-node=\"0\"\u003eStorage \u0026amp; Handling\u003c\/b\u003e\u003c\/h3\u003e\n\u003cul data-path-to-node=\"31\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"31,0,0\"\u003e\u003cb data-path-to-node=\"31,0,0\" data-index-in-node=\"0\"\u003ePhysical State:\u003c\/b\u003e Lyophilized (Freeze-Dried) White Powder.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"31,1,0\"\u003e\u003cb data-path-to-node=\"31,1,0\" data-index-in-node=\"0\"\u003eStorage (Powder):\u003c\/b\u003e Store at -20°C (Freezer). Stable for up to 24 months.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"31,2,0\"\u003e\u003cb data-path-to-node=\"31,2,0\" data-index-in-node=\"0\"\u003eReconstitution:\u003c\/b\u003e\u003c\/p\u003e\n\u003cul data-path-to-node=\"31,2,1\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"31,2,1,0,0\"\u003e\u003cb data-path-to-node=\"31,2,1,0,0\" data-index-in-node=\"0\"\u003eSolvent:\u003c\/b\u003e Sterile Water or Saline.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"31,2,1,1,0\"\u003e\u003cb data-path-to-node=\"31,2,1,1,0\" data-index-in-node=\"0\"\u003eSolubility:\u003c\/b\u003e Highly soluble.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"31,3,0\"\u003e\u003cb data-path-to-node=\"31,3,0\" data-index-in-node=\"0\"\u003eStorage (Liquid):\u003c\/b\u003e Store at 4°C (Refrigerator). Use within 14-21 days.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003chr data-path-to-node=\"32\"\u003e\n\u003ch3 data-path-to-node=\"33\"\u003e\u003cb data-path-to-node=\"33\" data-index-in-node=\"0\"\u003eDisclaimer\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp data-path-to-node=\"34\"\u003e\u003cb data-path-to-node=\"34\" data-index-in-node=\"0\"\u003eFOR RESEARCH USE ONLY.\u003c\/b\u003e This product is a chemical compound intended strictly for laboratory research and development. It is not approved by the FDA for clinical use, diagnostics, or therapeutic procedures in humans or animals. The physiological and toxicological properties of this chemical have not been fully investigated.\u003c\/p\u003e","brand":"Peptagon","offers":[{"title":"Default Title","offer_id":47712433406166,"sku":"PE2228-10","price":32.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0783\/3085\/5638\/files\/PE-22-28-10mmg.png?v=1768510335"},{"product_id":"peg-mgf-pegylated-mechano-growth-factor-research-peptide","title":"PEG MGF Research Peptide – 5mg","description":"\u003ch4 data-path-to-node=\"13\"\u003e\u003cstrong\u003ePEG MGF Peptide (Lyophilized)\u003c\/strong\u003e\u003c\/h4\u003e\n\u003cp data-path-to-node=\"14\"\u003e\u003cb data-path-to-node=\"14\" data-index-in-node=\"0\"\u003eSequence:\u003c\/b\u003e PEG-Suc-Tyr-Gln-Pro-Pro-Ser-Thr-Asn-Lys-Asn-Thr-Lys-Ser-Gln-Arg-Arg-Lys-Gly-Ser-Thr-Phe-Glu-Glu-Arg-Lys \u003cb data-path-to-node=\"14\" data-index-in-node=\"114\"\u003eFormat:\u003c\/b\u003e Sterile Lyophilized Powder (Vial) \u003cb data-path-to-node=\"14\" data-index-in-node=\"156\"\u003eModification:\u003c\/b\u003e Pegylation (Polyethylene Glycol Attachment) \u003cb data-path-to-node=\"14\" data-index-in-node=\"214\"\u003ePurity:\u003c\/b\u003e \u0026gt;98% (HPLC) \u003cb data-path-to-node=\"14\" data-index-in-node=\"234\"\u003eContent:\u003c\/b\u003e 5mg per vial\u003c\/p\u003e\n\u003chr data-path-to-node=\"15\"\u003e\n\u003ch3 data-path-to-node=\"16\"\u003e\u003cb data-path-to-node=\"16\" data-index-in-node=\"0\"\u003eProduct Overview\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp data-path-to-node=\"17\"\u003e\u003cb data-path-to-node=\"17\" data-index-in-node=\"0\"\u003ePEG MGF (Pegylated Mechano Growth Factor)\u003c\/b\u003e is a chemically stabilized form of the autocrine growth factor MGF. While native MGF has a half-life of just minutes, the attachment of a Polyethylene Glycol (PEG) polymer protects the peptide from enzymatic degradation, extending its biological activity to \u003cb data-path-to-node=\"17\" data-index-in-node=\"300\"\u003e48-72 hours\u003c\/b\u003e.\u003c\/p\u003e\n\u003cp data-path-to-node=\"18\"\u003eThis modification allows for systemic administration, enabling the peptide to reach distant tissues (muscle, heart, nervous system) to activate stem cells and promote tissue repair, overcoming the limitation of native MGF which acts only locally.\u003c\/p\u003e\n\u003chr data-path-to-node=\"19\"\u003e\n\u003ch3 data-path-to-node=\"20\"\u003e\u003cb data-path-to-node=\"20\" data-index-in-node=\"0\"\u003eMechanism of Action: The Sustained Activator\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp data-path-to-node=\"21\"\u003ePEG MGF functions by activating the \"Phase 1\" repair response in tissues.\u003c\/p\u003e\n\u003cul data-path-to-node=\"22\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"22,0,0\"\u003e\u003cb data-path-to-node=\"22,0,0\" data-index-in-node=\"0\"\u003eStem Cell Proliferation:\u003c\/b\u003e Activates the \u003cb data-path-to-node=\"22,0,0\" data-index-in-node=\"39\"\u003eMAPK\/ERK pathway\u003c\/b\u003e in satellite cells (muscle stem cells), driving them to multiply. This expands the population of cells available for repair before differentiation occurs.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"22,1,0\"\u003e\u003cb data-path-to-node=\"22,1,0\" data-index-in-node=\"0\"\u003ePharmacokinetic Stability:\u003c\/b\u003e The PEG shield increases the hydrodynamic volume of the molecule, preventing renal filtration and proteolysis. This transforms a fleeting local signal into a sustained systemic therapeutic.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"22,2,0\"\u003e\u003cb data-path-to-node=\"22,2,0\" data-index-in-node=\"0\"\u003eNeuroprotection:\u003c\/b\u003e Protects neurons from ischemia and degeneration by inhibiting apoptotic pathways, independent of the IGF-1 receptor.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003chr data-path-to-node=\"23\"\u003e\n\u003ch3 data-path-to-node=\"24\"\u003e\u003cb data-path-to-node=\"24\" data-index-in-node=\"0\"\u003eKey Research Applications\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp data-path-to-node=\"25\"\u003e\u003cb data-path-to-node=\"25\" data-index-in-node=\"0\"\u003e1. Systemic Muscle Recovery\u003c\/b\u003e Ideal for research into generalized muscle wasting or recovery. Because it circulates for days, a single subcutaneous injection can target multiple muscle groups, promoting the replenishment of the stem cell pool post-exercise or injury.\u003c\/p\u003e\n\u003cp data-path-to-node=\"26\"\u003e\u003cb data-path-to-node=\"26\" data-index-in-node=\"0\"\u003e2. Cardioprotection\u003c\/b\u003e In models of heart attack (myocardial infarction), PEG MGF reduces infarct size by preventing cardiomyocyte death and recruiting cardiac progenitor cells to the site of injury.\u003c\/p\u003e\n\u003cp data-path-to-node=\"27\"\u003e\u003cb data-path-to-node=\"27\" data-index-in-node=\"0\"\u003e3. Neurodegeneration \u0026amp; Stroke\u003c\/b\u003e Investigated for its ability to protect motor neurons in ALS models and rescue hippocampal neurons following stroke. The PEGylation allows for sustained neurotrophic support.\u003c\/p\u003e\n\u003chr data-path-to-node=\"28\"\u003e\n\u003ch3 data-path-to-node=\"29\"\u003e\u003cb data-path-to-node=\"29\" data-index-in-node=\"0\"\u003eStorage \u0026amp; Handling\u003c\/b\u003e\u003c\/h3\u003e\n\u003cul data-path-to-node=\"30\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"30,0,0\"\u003e\u003cb data-path-to-node=\"30,0,0\" data-index-in-node=\"0\"\u003ePhysical State:\u003c\/b\u003e Lyophilized (Freeze-Dried) White Powder.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"30,1,0\"\u003e\u003cb data-path-to-node=\"30,1,0\" data-index-in-node=\"0\"\u003eStorage (Powder):\u003c\/b\u003e Store at -20°C (Freezer). Stable for up to 12 months.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"30,2,0\"\u003e\u003cb data-path-to-node=\"30,2,0\" data-index-in-node=\"0\"\u003eReconstitution:\u003c\/b\u003e\u003c\/p\u003e\n\u003cul data-path-to-node=\"30,2,1\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"30,2,1,0,0\"\u003e\u003cb data-path-to-node=\"30,2,1,0,0\" data-index-in-node=\"0\"\u003eSolvent:\u003c\/b\u003e Bacteriostatic Water.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"30,2,1,1,0\"\u003e\u003cb data-path-to-node=\"30,2,1,1,0\" data-index-in-node=\"0\"\u003eSolubility:\u003c\/b\u003e Highly soluble.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"30,3,0\"\u003e\u003cb data-path-to-node=\"30,3,0\" data-index-in-node=\"0\"\u003eStorage (Liquid):\u003c\/b\u003e Store at 4°C (Refrigerator). \u003cb data-path-to-node=\"30,3,0\" data-index-in-node=\"47\"\u003eUse within 4 weeks.\u003c\/b\u003e PEGylation significantly improves stability in solution compared to native peptides.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003chr data-path-to-node=\"31\"\u003e\n\u003ch3 data-path-to-node=\"32\"\u003e\u003cb data-path-to-node=\"32\" data-index-in-node=\"0\"\u003eDisclaimer\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp data-path-to-node=\"33\"\u003e\u003cb data-path-to-node=\"33\" data-index-in-node=\"0\"\u003eFOR RESEARCH USE ONLY.\u003c\/b\u003e This product is a chemical compound intended strictly for laboratory research and development. It is not approved by the FDA for clinical use, diagnostics, or therapeutic procedures in humans or animals. The physiological and toxicological properties of this chemical have not been fully investigated.\u003c\/p\u003e","brand":"Peptagon","offers":[{"title":"Default Title","offer_id":47712435011798,"sku":"PEGMGF-5","price":67.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0783\/3085\/5638\/files\/PEG-MGF-5mg.png?v=1768507685"},{"product_id":"pnc-28-p53-derived-research-peptide","title":"PNC-28 Research Peptide – 20mg","description":"\u003ch4 data-path-to-node=\"13\"\u003e\u003cstrong\u003ePNC-28 Peptide (Lyophilized)\u003c\/strong\u003e\u003c\/h4\u003e\n\u003cp data-path-to-node=\"14\"\u003e\u003cb data-path-to-node=\"14\" data-index-in-node=\"0\"\u003eSequence:\u003c\/b\u003e ETFSDLWKLL-KKWKMRRNQFWVKVQRG (p53 17-26 + Penetratin) \u003cb data-path-to-node=\"14\" data-index-in-node=\"64\"\u003eFormat:\u003c\/b\u003e Sterile Lyophilized Powder (Vial) \u003cb data-path-to-node=\"14\" data-index-in-node=\"106\"\u003eMechanism:\u003c\/b\u003e MDM2-Mediated Membranolysis (Poptosis) \u003cb data-path-to-node=\"14\" data-index-in-node=\"156\"\u003ePurity:\u003c\/b\u003e \u0026gt;98% (HPLC) \u003cb data-path-to-node=\"14\" data-index-in-node=\"176\"\u003eContent:\u003c\/b\u003e 20mg per vial\u003c\/p\u003e\n\u003chr data-path-to-node=\"15\"\u003e\n\u003ch3 data-path-to-node=\"16\"\u003e\u003cb data-path-to-node=\"16\" data-index-in-node=\"0\"\u003eProduct Overview\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp data-path-to-node=\"17\"\u003e\u003cb data-path-to-node=\"17\" data-index-in-node=\"0\"\u003ePNC-28\u003c\/b\u003e is a synthetic fusion peptide derived from the p53 tumor suppressor protein. It consists of the p53 binding domain (residues 17-26) linked to a cell-penetrating \"penetratin\" sequence.\u003c\/p\u003e\n\u003cp data-path-to-node=\"18\"\u003eThis unique design allows PNC-28 to target malignant cells that overexpress MDM2 on their plasma membrane. Unlike traditional therapies that induce apoptosis, PNC-28 triggers a rapid form of necrosis known as \u003cb data-path-to-node=\"18\" data-index-in-node=\"209\"\u003e\"poptosis\"\u003c\/b\u003e (peptide-induced transmembrane pore formation), making it a critical tool for researching chemotherapy-resistant cell lines.\u003c\/p\u003e\n\u003chr data-path-to-node=\"19\"\u003e\n\u003ch3 data-path-to-node=\"20\"\u003e\u003cb data-path-to-node=\"20\" data-index-in-node=\"0\"\u003eMechanism of Action: The Necrotic Trigger\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp data-path-to-node=\"21\"\u003ePNC-28 operates via a biophysical mechanism distinct from standard p53 stabilizers.\u003c\/p\u003e\n\u003cul data-path-to-node=\"22\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"22,0,0\"\u003e\u003cb data-path-to-node=\"22,0,0\" data-index-in-node=\"0\"\u003eMDM2 Targeting:\u003c\/b\u003e The p53 segment binds to MDM2 proteins located on the surface of cancer cells (but absent on normal cells).\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"22,1,0\"\u003e\u003cb data-path-to-node=\"22,1,0\" data-index-in-node=\"0\"\u003ePore Formation:\u003c\/b\u003e Upon binding, the peptide undergoes a conformational change, assembling into oligomers that penetrate the cell membrane.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"22,2,0\"\u003e\u003cb data-path-to-node=\"22,2,0\" data-index-in-node=\"0\"\u003eRapid Lysis:\u003c\/b\u003e These oligomers form transmembrane pores (approx. 37 nm diameter), causing immediate leakage of intracellular contents and necrotic cell death, independent of intracellular p53 status.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003chr data-path-to-node=\"23\"\u003e\n\u003ch3 data-path-to-node=\"24\"\u003e\u003cb data-path-to-node=\"24\" data-index-in-node=\"0\"\u003eKey Research Applications\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp data-path-to-node=\"25\"\u003e\u003cb data-path-to-node=\"25\" data-index-in-node=\"0\"\u003e1. Malignant Cell Research\u003c\/b\u003e Investigated for its selective cytotoxicity against pancreatic (MiaPaCa-2), breast (MCF-7), and ovarian (SK-OV-3) cancer lines. Research shows it induces \u003cb data-path-to-node=\"25\" data-index-in-node=\"181\"\u003e100% cell death\u003c\/b\u003e in susceptible lines within 24-48 hours.\u003c\/p\u003e\n\u003cp data-path-to-node=\"26\"\u003e\u003cb data-path-to-node=\"26\" data-index-in-node=\"0\"\u003e2. Non-Apoptotic Pathways\u003c\/b\u003e Used to study cell death mechanisms that bypass traditional apoptosis resistance (e.g., Bcl-2 overexpression), offering a model for treating drug-resistant phenotypes.\u003c\/p\u003e\n\u003cp data-path-to-node=\"27\"\u003e\u003cb data-path-to-node=\"27\" data-index-in-node=\"0\"\u003e3. Stem Cell Selectivity\u003c\/b\u003e Studies indicate PNC-28 targets leukemia stem cells (LSCs) while sparing normal hematopoietic stem cells, making it a valuable probe for selective oncology research.\u003c\/p\u003e\n\u003chr data-path-to-node=\"28\"\u003e\n\u003ch3 data-path-to-node=\"29\"\u003e\u003cb data-path-to-node=\"29\" data-index-in-node=\"0\"\u003eStorage \u0026amp; Handling\u003c\/b\u003e\u003c\/h3\u003e\n\u003cul data-path-to-node=\"30\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"30,0,0\"\u003e\u003cb data-path-to-node=\"30,0,0\" data-index-in-node=\"0\"\u003ePhysical State:\u003c\/b\u003e Lyophilized (Freeze-Dried) White Powder.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"30,1,0\"\u003e\u003cb data-path-to-node=\"30,1,0\" data-index-in-node=\"0\"\u003eStorage (Powder):\u003c\/b\u003e Store at -20°C (Freezer). Stable for up to 24 months.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"30,2,0\"\u003e\u003cb data-path-to-node=\"30,2,0\" data-index-in-node=\"0\"\u003eReconstitution:\u003c\/b\u003e\u003c\/p\u003e\n\u003cul data-path-to-node=\"30,2,1\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"30,2,1,0,0\"\u003e\u003cb data-path-to-node=\"30,2,1,0,0\" data-index-in-node=\"0\"\u003eSolvent:\u003c\/b\u003e Sterile Water or 10-30% Acetic Acid (if solubility is low).\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"30,2,1,1,0\"\u003e\u003cb data-path-to-node=\"30,2,1,1,0\" data-index-in-node=\"0\"\u003eSonication:\u003c\/b\u003e May be required due to the peptide's amphipathic nature.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"30,3,0\"\u003e\u003cb data-path-to-node=\"30,3,0\" data-index-in-node=\"0\"\u003eStorage (Liquid):\u003c\/b\u003e Store at 4°C. Use within 14 days. \u003cb data-path-to-node=\"30,3,0\" data-index-in-node=\"52\"\u003eAvoid freeze-thaw cycles.\u003c\/b\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003chr data-path-to-node=\"31\"\u003e\n\u003ch3 data-path-to-node=\"32\"\u003e\u003cb data-path-to-node=\"32\" data-index-in-node=\"0\"\u003eDisclaimer\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp data-path-to-node=\"33\"\u003e\u003cb data-path-to-node=\"33\" data-index-in-node=\"0\"\u003eFOR RESEARCH USE ONLY.\u003c\/b\u003e This product is a chemical compound intended strictly for laboratory research and development. It is not approved by the FDA for clinical use, diagnostics, or therapeutic procedures in humans or animals. The physiological and toxicological properties of this chemical have not been fully investigated.\u003c\/p\u003e","brand":"Peptagon","offers":[{"title":"Default Title","offer_id":47712473153750,"sku":"PNC28-20","price":165.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0783\/3085\/5638\/files\/PNC-28-20mg.png?v=1768510757"},{"product_id":"selank-tuftsin-analog-research-peptide","title":"Selank Research Peptide – 5mg \/ 10mg","description":"\u003ch4 data-path-to-node=\"13\"\u003e\u003cstrong\u003eSelank Peptide (Lyophilized)\u003c\/strong\u003e\u003c\/h4\u003e\n\u003cp data-path-to-node=\"14\"\u003e\u003cb data-path-to-node=\"14\" data-index-in-node=\"0\"\u003eSequence:\u003c\/b\u003e Thr-Lys-Pro-Arg-Pro-Gly-Pro (TKPRPGP) \u003cb data-path-to-node=\"14\" data-index-in-node=\"48\"\u003eFormat:\u003c\/b\u003e Sterile Lyophilized Powder (Vial) \u003cb data-path-to-node=\"14\" data-index-in-node=\"90\"\u003eClass:\u003c\/b\u003e Nootropic \/ Anxiolytic \/ Immunomodulator \u003cb data-path-to-node=\"14\" data-index-in-node=\"138\"\u003ePurity:\u003c\/b\u003e \u0026gt;98% (HPLC) \u003cb data-path-to-node=\"14\" data-index-in-node=\"158\"\u003eContent:\u003c\/b\u003e 10mg per vial\u003c\/p\u003e\n\u003chr data-path-to-node=\"15\"\u003e\n\u003ch3 data-path-to-node=\"16\"\u003e\u003cb data-path-to-node=\"16\" data-index-in-node=\"0\"\u003eProduct Overview\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp data-path-to-node=\"17\"\u003e\u003cb data-path-to-node=\"17\" data-index-in-node=\"0\"\u003eSelank\u003c\/b\u003e is a synthetic heptapeptide derivative of the endogenous immunomodulator Tuftsin. It was originally developed at the Institute of Molecular Genetics (Russian Academy of Sciences) to combine anxiolytic (anti-anxiety) properties with nootropic (cognitive enhancing) effects.\u003c\/p\u003e\n\u003cp data-path-to-node=\"18\"\u003eSelank is unique in that it modulates the central nervous system without the sedation, addiction, or withdrawal symptoms associated with traditional benzodiazepines. It also retains the immune-boosting properties of its parent molecule, making it a dual-action \"neuro-immunomodulator.\"\u003c\/p\u003e\n\u003chr data-path-to-node=\"19\"\u003e\n\u003ch3 data-path-to-node=\"20\"\u003e\u003cb data-path-to-node=\"20\" data-index-in-node=\"0\"\u003eMechanism of Action: The Neuro-Regulator\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp data-path-to-node=\"21\"\u003eSelank acts as a homeostatic regulator of the nervous system.\u003c\/p\u003e\n\u003cul data-path-to-node=\"22\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"22,0,0\"\u003e\u003cb data-path-to-node=\"22,0,0\" data-index-in-node=\"0\"\u003eGABA Modulation:\u003c\/b\u003e It acts as a positive allosteric modulator of GABA-A receptors, enhancing the natural inhibitory tone of the brain to reduce anxiety and stress without sedation.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"22,1,0\"\u003e\u003cb data-path-to-node=\"22,1,0\" data-index-in-node=\"0\"\u003eEnkephalinase Inhibition:\u003c\/b\u003e Inhibits the enzymes that break down enkephalins (natural opioids), increasing their levels to stabilize mood and reduce pain perception.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"22,2,0\"\u003e\u003cb data-path-to-node=\"22,2,0\" data-index-in-node=\"0\"\u003eBDNF Upregulation:\u003c\/b\u003e Rapidly increases Brain-Derived Neurotrophic Factor (BDNF) in the hippocampus, promoting neuronal survival, synaptic plasticity, and memory consolidation.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"22,3,0\"\u003e\u003cb data-path-to-node=\"22,3,0\" data-index-in-node=\"0\"\u003eTranscriptomic Regulation:\u003c\/b\u003e Modulates the expression of inflammation-related genes (NF-κB, IL-6), protecting the brain from neuroinflammation.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003chr data-path-to-node=\"23\"\u003e\n\u003ch3 data-path-to-node=\"24\"\u003e\u003cb data-path-to-node=\"24\" data-index-in-node=\"0\"\u003eKey Research Applications\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp data-path-to-node=\"25\"\u003e\u003cb data-path-to-node=\"25\" data-index-in-node=\"0\"\u003e1. Anxiety \u0026amp; Stress Disorders\u003c\/b\u003e Selank is the benchmark for researching non-sedating anxiolytics. Clinical studies show it reduces symptoms of Generalized Anxiety Disorder (GAD) and neurasthenia, with 40% of subjects showing rapid improvement within 1-3 days.\u003c\/p\u003e\n\u003cp data-path-to-node=\"26\"\u003e\u003cb data-path-to-node=\"26\" data-index-in-node=\"0\"\u003e2. Cognitive Enhancement (Nootropic)\u003c\/b\u003e Investigated for its ability to improve memory stability, focus, and learning capacity. It aids in the consolidation of memory traces, making it a valuable tool for researching cognitive decline and ADHD.\u003c\/p\u003e\n\u003cp data-path-to-node=\"27\"\u003e\u003cb data-path-to-node=\"27\" data-index-in-node=\"0\"\u003e3. Neuroprotection \u0026amp; Immunology\u003c\/b\u003e Due to its Tuftsin lineage, Selank modulates the immune response (IL-6 suppression) and protects neurons from oxidative stress and excitotoxicity, relevant for research into viral infections and neurodegenerative diseases.\u003c\/p\u003e\n\u003chr data-path-to-node=\"28\"\u003e\n\u003ch3 data-path-to-node=\"29\"\u003e\u003cb data-path-to-node=\"29\" data-index-in-node=\"0\"\u003eStorage \u0026amp; Handling\u003c\/b\u003e\u003c\/h3\u003e\n\u003cul data-path-to-node=\"30\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"30,0,0\"\u003e\u003cb data-path-to-node=\"30,0,0\" data-index-in-node=\"0\"\u003ePhysical State:\u003c\/b\u003e Lyophilized (Freeze-Dried) White Powder.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"30,1,0\"\u003e\u003cb data-path-to-node=\"30,1,0\" data-index-in-node=\"0\"\u003eStorage (Powder):\u003c\/b\u003e Store at -20°C (Freezer). Stable for up to 36 months.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"30,2,0\"\u003e\u003cb data-path-to-node=\"30,2,0\" data-index-in-node=\"0\"\u003eReconstitution:\u003c\/b\u003e\u003c\/p\u003e\n\u003cul data-path-to-node=\"30,2,1\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"30,2,1,0,0\"\u003e\u003cb data-path-to-node=\"30,2,1,0,0\" data-index-in-node=\"0\"\u003eSolvent:\u003c\/b\u003e Sterile Water or Bacteriostatic Water.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"30,2,1,1,0\"\u003e\u003cb data-path-to-node=\"30,2,1,1,0\" data-index-in-node=\"0\"\u003eSolubility:\u003c\/b\u003e Highly soluble.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"30,3,0\"\u003e\u003cb data-path-to-node=\"30,3,0\" data-index-in-node=\"0\"\u003eStorage (Liquid):\u003c\/b\u003e Store at 4°C (Refrigerator). \u003cb data-path-to-node=\"30,3,0\" data-index-in-node=\"47\"\u003eUse within 14-21 days.\u003c\/b\u003e Selank is sensitive to heat; keep refrigerated at all times after mixing.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003chr data-path-to-node=\"31\"\u003e\n\u003ch3 data-path-to-node=\"32\"\u003e\u003cb data-path-to-node=\"32\" data-index-in-node=\"0\"\u003eDisclaimer\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp data-path-to-node=\"33\"\u003e\u003cb data-path-to-node=\"33\" data-index-in-node=\"0\"\u003eFOR RESEARCH USE ONLY.\u003c\/b\u003e This product is a chemical compound intended strictly for laboratory research and development. It is not approved by the FDA for clinical use, diagnostics, or therapeutic procedures in humans or animals. The physiological and toxicological properties of this chemical have not been fully investigated.\u003c\/p\u003e","brand":"Peptagon","offers":[{"title":"5mg","offer_id":47712538820822,"sku":"SELANK-5","price":29.0,"currency_code":"USD","in_stock":true},{"title":"10mg","offer_id":47712538853590,"sku":"SELANK-10","price":37.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0783\/3085\/5638\/files\/Selank-5mg.png?v=1768507725"},{"product_id":"semax-acth-4-10-analog-research-peptide","title":"Semax Research Peptide – 30mg","description":"\u003ch4 data-path-to-node=\"13\"\u003e\u003cstrong\u003eSemax Peptide (Lyophilized)\u003c\/strong\u003e\u003c\/h4\u003e\n\u003cp data-path-to-node=\"14\"\u003e\u003cb data-path-to-node=\"14\" data-index-in-node=\"0\"\u003eSequence:\u003c\/b\u003e Met-Glu-His-Phe-Pro-Gly-Pro (MEHFPGP) \u003cb data-path-to-node=\"14\" data-index-in-node=\"48\"\u003eFormat:\u003c\/b\u003e Sterile Lyophilized Powder (Vial) \u003cb data-path-to-node=\"14\" data-index-in-node=\"90\"\u003eClass:\u003c\/b\u003e Nootropic \/ Neuroprotective Peptide \u003cb data-path-to-node=\"14\" data-index-in-node=\"133\"\u003ePurity:\u003c\/b\u003e \u0026gt;98% (HPLC) \u003cb data-path-to-node=\"14\" data-index-in-node=\"153\"\u003eContent:\u003c\/b\u003e 30mg per vial\u003c\/p\u003e\n\u003chr data-path-to-node=\"15\"\u003e\n\u003ch3 data-path-to-node=\"16\"\u003e\u003cb data-path-to-node=\"16\" data-index-in-node=\"0\"\u003eProduct Overview\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp data-path-to-node=\"17\"\u003e\u003cb data-path-to-node=\"17\" data-index-in-node=\"0\"\u003eSemax\u003c\/b\u003e is a synthetic heptapeptide derived from the ACTH(4-10) fragment. It was engineered at the Institute of Molecular Genetics (Russian Academy of Sciences) to retain the potent neurotropic effects of ACTH—such as improved learning and memory—without any hormonal or steroidogenic activity.\u003c\/p\u003e\n\u003cp data-path-to-node=\"18\"\u003eThis \u003cb data-path-to-node=\"18\" data-index-in-node=\"5\"\u003e30mg High-Concentration Formulation\u003c\/b\u003e is designed for advanced research protocols, specifically those investigating acute neuroprotection (e.g., post-stroke or TBI models) where higher cumulative doses are required to modulate the brain's transcriptome and suppress inflammatory gene clusters.\u003c\/p\u003e\n\u003chr data-path-to-node=\"19\"\u003e\n\u003ch3 data-path-to-node=\"20\"\u003e\u003cb data-path-to-node=\"20\" data-index-in-node=\"0\"\u003eMechanism of Action: The Genomic Modulator\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp data-path-to-node=\"21\"\u003eSemax operates via rapid transcriptional and enzymatic regulation in the central nervous system.\u003c\/p\u003e\n\u003cul data-path-to-node=\"22\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"22,0,0\"\u003e\u003cb data-path-to-node=\"22,0,0\" data-index-in-node=\"0\"\u003eNeurotrophic Upregulation:\u003c\/b\u003e Significantly increases the expression of \u003cb data-path-to-node=\"22,0,0\" data-index-in-node=\"69\"\u003eBDNF (Brain-Derived Neurotrophic Factor)\u003c\/b\u003e and \u003cb data-path-to-node=\"22,0,0\" data-index-in-node=\"114\"\u003eNGF (Nerve Growth Factor)\u003c\/b\u003e in the hippocampus and cortex. This promotes neuronal survival, synaptic plasticity, and axonal growth.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"22,1,0\"\u003e\u003cb data-path-to-node=\"22,1,0\" data-index-in-node=\"0\"\u003eTranscriptomic Reset:\u003c\/b\u003e In models of ischemia (stroke), Semax modulates the expression of over 1,500 genes. It specifically suppresses inflammatory gene clusters (e.g., \u003ci data-path-to-node=\"22,1,0\" data-index-in-node=\"167\"\u003eMmp9\u003c\/i\u003e, \u003ci data-path-to-node=\"22,1,0\" data-index-in-node=\"173\"\u003eNfkb\u003c\/i\u003e) while upregulating vascular and neurotransmitter genes, limiting the \"penumbra\" of damage.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"22,2,0\"\u003e\u003cb data-path-to-node=\"22,2,0\" data-index-in-node=\"0\"\u003eNeurotransmitter Balance:\u003c\/b\u003e Enhances dopaminergic and serotonergic signaling while inhibiting enkephalinases (enzymes that break down natural opioids), improving mood, focus, and pain tolerance.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003chr data-path-to-node=\"23\"\u003e\n\u003ch3 data-path-to-node=\"24\"\u003e\u003cb data-path-to-node=\"24\" data-index-in-node=\"0\"\u003eKey Research Applications\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp data-path-to-node=\"25\"\u003e\u003cb data-path-to-node=\"25\" data-index-in-node=\"0\"\u003e1. Stroke \u0026amp; Traumatic Brain Injury (TBI)\u003c\/b\u003e Semax is a primary candidate for neuroprotection. Clinical and preclinical data indicate it reduces infarct volume by up to \u003cb data-path-to-node=\"25\" data-index-in-node=\"165\"\u003e25%\u003c\/b\u003e and accelerates neurological recovery when administered in the acute phase of injury.\u003c\/p\u003e\n\u003cp data-path-to-node=\"26\"\u003e\u003cb data-path-to-node=\"26\" data-index-in-node=\"0\"\u003e2. Cognitive Enhancement (Nootropic)\u003c\/b\u003e Investigated for its ability to improve memory formation, attention span, and learning efficiency. It is used in research models of ADHD and developmental delay to normalize behavioral responses and cognitive processing.\u003c\/p\u003e\n\u003cp data-path-to-node=\"27\"\u003e\u003cb data-path-to-node=\"27\" data-index-in-node=\"0\"\u003e3. Ophthalmology (Retinal Protection)\u003c\/b\u003e Studies show Semax improves retinal microcirculation and electrical sensitivity of the optic nerve, making it a valuable tool for research into optic neuropathy, glaucoma, and diabetic retinopathy.\u003c\/p\u003e\n\u003chr data-path-to-node=\"28\"\u003e\n\u003ch3 data-path-to-node=\"29\"\u003e\u003cb data-path-to-node=\"29\" data-index-in-node=\"0\"\u003eStorage \u0026amp; Handling\u003c\/b\u003e\u003c\/h3\u003e\n\u003cul data-path-to-node=\"30\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"30,0,0\"\u003e\u003cb data-path-to-node=\"30,0,0\" data-index-in-node=\"0\"\u003ePhysical State:\u003c\/b\u003e Lyophilized (Freeze-Dried) White Powder.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"30,1,0\"\u003e\u003cb data-path-to-node=\"30,1,0\" data-index-in-node=\"0\"\u003eStorage (Powder):\u003c\/b\u003e Store at -20°C (Freezer). Stable for up to 24 months.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"30,2,0\"\u003e\u003cb data-path-to-node=\"30,2,0\" data-index-in-node=\"0\"\u003eReconstitution:\u003c\/b\u003e\u003c\/p\u003e\n\u003cul data-path-to-node=\"30,2,1\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"30,2,1,0,0\"\u003e\u003cb data-path-to-node=\"30,2,1,0,0\" data-index-in-node=\"0\"\u003eSolvent:\u003c\/b\u003e Sterile Water or Bacteriostatic Water.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"30,2,1,1,0\"\u003e\u003cb data-path-to-node=\"30,2,1,1,0\" data-index-in-node=\"0\"\u003eSolubility:\u003c\/b\u003e Highly soluble (\u0026gt;2mg\/mL).\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"30,3,0\"\u003e\u003cb data-path-to-node=\"30,3,0\" data-index-in-node=\"0\"\u003eStorage (Liquid):\u003c\/b\u003e Store at 4°C (Refrigerator). \u003cb data-path-to-node=\"30,3,0\" data-index-in-node=\"47\"\u003eUse within 14-21 days.\u003c\/b\u003e Semax degrades over time in solution; aliquoting and freezing is recommended for long-term experiments.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003chr data-path-to-node=\"31\"\u003e\n\u003ch3 data-path-to-node=\"32\"\u003e\u003cb data-path-to-node=\"32\" data-index-in-node=\"0\"\u003eDisclaimer\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp data-path-to-node=\"33\"\u003e\u003cb data-path-to-node=\"33\" data-index-in-node=\"0\"\u003eFOR RESEARCH USE ONLY.\u003c\/b\u003e This product is a chemical compound intended strictly for laboratory research and development. It is not approved by the FDA for clinical use, diagnostics, or therapeutic procedures in humans or animals. The physiological and toxicological properties of this chemical have not been fully investigated.\u003c\/p\u003e","brand":"Peptagon","offers":[{"title":"Default Title","offer_id":47712591118550,"sku":"SEMAX-30","price":50.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0783\/3085\/5638\/files\/Semax-30mg.png?v=1768507779"},{"product_id":"thymagen-thymomimetic-dipeptide-research-peptide","title":"Thymagen Research Peptide – 20mg","description":"\u003ch4 data-path-to-node=\"13\"\u003e\u003cstrong\u003eThymogen Peptide (Lyophilized)\u003c\/strong\u003e\u003c\/h4\u003e\n\u003cp data-path-to-node=\"14\"\u003e\u003cb data-path-to-node=\"14\" data-index-in-node=\"0\"\u003eSequence:\u003c\/b\u003e L-Glu-L-Trp (EW) \u003cb data-path-to-node=\"14\" data-index-in-node=\"27\"\u003eFormat:\u003c\/b\u003e Sterile Lyophilized Powder (Vial) \u003cb data-path-to-node=\"14\" data-index-in-node=\"69\"\u003eClass:\u003c\/b\u003e Thymic Bioregulator \/ Immunomodulator \u003cb data-path-to-node=\"14\" data-index-in-node=\"114\"\u003ePurity:\u003c\/b\u003e \u0026gt;98% (HPLC) \u003cb data-path-to-node=\"14\" data-index-in-node=\"134\"\u003eContent:\u003c\/b\u003e 20mg per vial\u003c\/p\u003e\n\u003chr data-path-to-node=\"15\"\u003e\n\u003ch3 data-path-to-node=\"16\"\u003e\u003cb data-path-to-node=\"16\" data-index-in-node=\"0\"\u003eProduct Overview\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp data-path-to-node=\"17\"\u003e\u003cb data-path-to-node=\"17\" data-index-in-node=\"0\"\u003eThymogen\u003c\/b\u003e is a synthetic dipeptide (Glutamic Acid - Tryptophan) developed as a bioregulator to mimic the natural signaling of the thymus gland. Originally isolated from thymic extracts, this stabilized dipeptide acts as a \"thymomimetic,\" signaling the maturation and differentiation of T-cells even when thymic function is compromised by age or stress.\u003c\/p\u003e\n\u003cp data-path-to-node=\"18\"\u003eThymogen is unique in its ability to normalize immune function—boosting suppressed immunity while stabilizing hyper-inflammatory states—without the immunogenicity of larger proteins. It is widely researched for its role in reversing immunosenescence and modulating the innate immune response via Toll-like receptors.\u003c\/p\u003e\n\u003chr data-path-to-node=\"19\"\u003e\n\u003ch3 data-path-to-node=\"20\"\u003e\u003cb data-path-to-node=\"20\" data-index-in-node=\"0\"\u003eMechanism of Action: The Immune Architect\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp data-path-to-node=\"21\"\u003eThymogen operates at the genetic and cellular level to restore immune homeostasis.\u003c\/p\u003e\n\u003cul data-path-to-node=\"22\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"22,0,0\"\u003e\u003cb data-path-to-node=\"22,0,0\" data-index-in-node=\"0\"\u003eT-Cell Maturation:\u003c\/b\u003e Stimulates the differentiation of hematopoietic stem cells into functional CD3+, CD4+, and CD8+ T-lymphocytes via the \u003cb data-path-to-node=\"22,0,0\" data-index-in-node=\"137\"\u003eNotch signaling pathway\u003c\/b\u003e.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"22,1,0\"\u003e\u003cb data-path-to-node=\"22,1,0\" data-index-in-node=\"0\"\u003eInnate Activation:\u003c\/b\u003e Upregulates the expression of \u003cb data-path-to-node=\"22,1,0\" data-index-in-node=\"49\"\u003eToll-like Receptors (TLR3, 7, 8, 9)\u003c\/b\u003e and cytoplasmic sensors (RIG-I), enhancing the body's ability to detect and respond to viral pathogens.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"22,2,0\"\u003e\u003cb data-path-to-node=\"22,2,0\" data-index-in-node=\"0\"\u003eEpigenetic Regulation:\u003c\/b\u003e Acts as a Khavinson peptide, penetrating the nucleus to modulate gene expression related to cytokine synthesis and DNA repair, effectively slowing the rate of thymic involution (atrophy).\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003chr data-path-to-node=\"23\"\u003e\n\u003ch3 data-path-to-node=\"24\"\u003e\u003cb data-path-to-node=\"24\" data-index-in-node=\"0\"\u003eKey Research Applications\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp data-path-to-node=\"25\"\u003e\u003cb data-path-to-node=\"25\" data-index-in-node=\"0\"\u003e1. Immunosenescence \u0026amp; Aging\u003c\/b\u003e Thymogen is a primary candidate for \"geroprotection\" research. Studies indicate it can restore T-cell populations in aged models, countering the natural decline of the immune system and improving resistance to infections.\u003c\/p\u003e\n\u003cp data-path-to-node=\"26\"\u003e\u003cb data-path-to-node=\"26\" data-index-in-node=\"0\"\u003e2. Viral Defense \u0026amp; Respiratory Health\u003c\/b\u003e Investigated for its virucidal properties and ability to prime the innate immune system. In vitro studies show it inhibits the replication of respiratory viruses (RSV, Influenza) by activating the MyD88\/IRAK1 signaling cascade.\u003c\/p\u003e\n\u003cp data-path-to-node=\"27\"\u003e\u003cb data-path-to-node=\"27\" data-index-in-node=\"0\"\u003e3. Autoimmunity \u0026amp; Inflammation\u003c\/b\u003e Research suggests Thymogen acts as an immunocorrector, normalizing the CD4\/CD8 ratio and suppressing excessive pro-inflammatory cytokines (TNF-alpha, IL-6) in conditions like chronic inflammation or autoimmune disorders.\u003c\/p\u003e\n\u003chr data-path-to-node=\"28\"\u003e\n\u003ch3 data-path-to-node=\"29\"\u003e\u003cb data-path-to-node=\"29\" data-index-in-node=\"0\"\u003eStorage \u0026amp; Handling\u003c\/b\u003e\u003c\/h3\u003e\n\u003cul data-path-to-node=\"30\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"30,0,0\"\u003e\u003cb data-path-to-node=\"30,0,0\" data-index-in-node=\"0\"\u003ePhysical State:\u003c\/b\u003e Lyophilized (Freeze-Dried) White Powder.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"30,1,0\"\u003e\u003cb data-path-to-node=\"30,1,0\" data-index-in-node=\"0\"\u003eStorage (Powder):\u003c\/b\u003e Store at -20°C (Freezer). Stable for up to 36 months.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"30,2,0\"\u003e\u003cb data-path-to-node=\"30,2,0\" data-index-in-node=\"0\"\u003eReconstitution:\u003c\/b\u003e\u003c\/p\u003e\n\u003cul data-path-to-node=\"30,2,1\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"30,2,1,0,0\"\u003e\u003cb data-path-to-node=\"30,2,1,0,0\" data-index-in-node=\"0\"\u003eSolvent:\u003c\/b\u003e Bacteriostatic Water or Sterile Saline.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"30,2,1,1,0\"\u003e\u003cb data-path-to-node=\"30,2,1,1,0\" data-index-in-node=\"0\"\u003eSolubility:\u003c\/b\u003e Highly soluble in water (\u0026gt;10mg\/mL).\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"30,3,0\"\u003e\u003cb data-path-to-node=\"30,3,0\" data-index-in-node=\"0\"\u003eStorage (Liquid):\u003c\/b\u003e Store at 4°C (Refrigerator). \u003cb data-path-to-node=\"30,3,0\" data-index-in-node=\"47\"\u003eUse within 2-4 weeks.\u003c\/b\u003e Avoid freeze-thaw cycles.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003chr data-path-to-node=\"31\"\u003e\n\u003ch3 data-path-to-node=\"32\"\u003e\u003cb data-path-to-node=\"32\" data-index-in-node=\"0\"\u003eDisclaimer\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp data-path-to-node=\"33\"\u003e\u003cb data-path-to-node=\"33\" data-index-in-node=\"0\"\u003eFOR RESEARCH USE ONLY.\u003c\/b\u003e This product is a chemical compound intended strictly for laboratory research and development. It is not approved by the FDA for clinical use, diagnostics, or therapeutic procedures in humans or animals. The physiological and toxicological properties of this chemical have not been fully investigated.\u003c\/p\u003e","brand":"Peptagon","offers":[{"title":"Default Title","offer_id":47712623853782,"sku":"THYMAGEN-20","price":38.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0783\/3085\/5638\/files\/Thymagen-20mg.png?v=1768508109"},{"product_id":"thymosin-alpha-1-thymalfasin-10mg-research-peptide","title":"Thymosin Alpha 1 Research Peptide – 10mg","description":"\u003ch4 data-path-to-node=\"13\"\u003e\u003cstrong\u003eThymosin Alpha 1 Peptide (Lyophilized)\u003c\/strong\u003e\u003c\/h4\u003e\n\u003cp data-path-to-node=\"14\"\u003e\u003cb data-path-to-node=\"14\" data-index-in-node=\"0\"\u003eSequence:\u003c\/b\u003e Ac-Ser-Asp-Ala-Ala-Val-Asp-Thr-Ser-Ser-Glu-Ile-Thr-Thr-Lys-Asp-Leu-Lys-Glu-Lys-Lys-Glu-Val-Val-Glu-Glu-Ala-Glu-Asn-OH \u003cb data-path-to-node=\"14\" data-index-in-node=\"128\"\u003eFormat:\u003c\/b\u003e Sterile Lyophilized Powder (Vial) \u003cb data-path-to-node=\"14\" data-index-in-node=\"170\"\u003eClass:\u003c\/b\u003e Biological Response Modifier (Thymic Peptide) \u003cb data-path-to-node=\"14\" data-index-in-node=\"223\"\u003ePurity:\u003c\/b\u003e \u0026gt;98% (HPLC) \u003cb data-path-to-node=\"14\" data-index-in-node=\"243\"\u003eContent:\u003c\/b\u003e 10mg per vial\u003c\/p\u003e\n\u003chr data-path-to-node=\"15\"\u003e\n\u003ch3 data-path-to-node=\"16\"\u003e\u003cb data-path-to-node=\"16\" data-index-in-node=\"0\"\u003eProduct Overview\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp data-path-to-node=\"17\"\u003e\u003cb data-path-to-node=\"17\" data-index-in-node=\"0\"\u003eThymosin Alpha 1 (TA1)\u003c\/b\u003e is a synthetic 28-amino acid peptide identical to the naturally occurring thymic hormone. It serves as a master regulator of the immune system, orchestrating the maturation of T-cells and the balance between innate and adaptive immunity.\u003c\/p\u003e\n\u003cp data-path-to-node=\"18\"\u003eTA1 is unique in its ability to restore immune function in immunocompromised states (e.g., aging, chronic infection) without causing the \"cytokine storms\" associated with non-specific immune boosters. It is widely researched for its role in fighting viral infections, enhancing vaccine efficacy, and serving as an adjunct in cancer immunotherapy.\u003c\/p\u003e\n\u003chr data-path-to-node=\"19\"\u003e\n\u003ch3 data-path-to-node=\"20\"\u003e\u003cb data-path-to-node=\"20\" data-index-in-node=\"0\"\u003eMechanism of Action: The Immune Conductor\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp data-path-to-node=\"21\"\u003eTA1 operates by activating key immune signaling pathways.\u003c\/p\u003e\n\u003cul data-path-to-node=\"22\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"22,0,0\"\u003e\u003cb data-path-to-node=\"22,0,0\" data-index-in-node=\"0\"\u003eTLR Activation:\u003c\/b\u003e Agonizes Toll-like Receptors (TLR9\/TLR2) on dendritic cells, triggering the \u003cb data-path-to-node=\"22,0,0\" data-index-in-node=\"92\"\u003eMyD88-IRAK1-NF-κB\u003c\/b\u003e signaling cascade. This primes the innate immune system to detect and destroy pathogens.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"22,1,0\"\u003e\u003cb data-path-to-node=\"22,1,0\" data-index-in-node=\"0\"\u003eT-Cell Maturation:\u003c\/b\u003e Stimulates the differentiation of progenitor cells into functional CD4+ and CD8+ T-cells via the \u003cb data-path-to-node=\"22,1,0\" data-index-in-node=\"116\"\u003eNotch signaling pathway\u003c\/b\u003e, reversing thymic involution (aging).\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"22,2,0\"\u003e\u003cb data-path-to-node=\"22,2,0\" data-index-in-node=\"0\"\u003eImmune Balance:\u003c\/b\u003e Modulates the Th1\/Th2 balance, promoting specific anti-viral\/anti-tumor responses (Th1) while preventing excessive inflammation via Regulatory T-cells (Tregs).\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003chr data-path-to-node=\"23\"\u003e\n\u003ch3 data-path-to-node=\"24\"\u003e\u003cb data-path-to-node=\"24\" data-index-in-node=\"0\"\u003eKey Research Applications\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp data-path-to-node=\"25\"\u003e\u003cb data-path-to-node=\"25\" data-index-in-node=\"0\"\u003e1. Infectious Disease ( Viral \u0026amp; Bacterial)\u003c\/b\u003e TA1 is extensively studied for its ability to reduce mortality in sepsis and severe respiratory infections. It boosts T-cell counts and clears viral antigens in chronic Hepatitis B and C, often used where other treatments fail.\u003c\/p\u003e\n\u003cp data-path-to-node=\"26\"\u003e\u003cb data-path-to-node=\"26\" data-index-in-node=\"0\"\u003e2. Cancer Immunotherapy\u003c\/b\u003e Acts as an adjuvant to checkpoint inhibitors (e.g., PD-1 blockers). Research shows it enhances antigen presentation, reduces chemotherapy-induced toxicity, and activates T-cells to attack tumors in melanoma and lung cancer models.\u003c\/p\u003e\n\u003cp data-path-to-node=\"27\"\u003e\u003cb data-path-to-node=\"27\" data-index-in-node=\"0\"\u003e3. Regenerative Medicine \u0026amp; Aging\u003c\/b\u003e Investigated for its ability to accelerate wound healing by promoting angiogenesis (new blood vessel growth) and keratinocyte migration. It also counters \"immunosenescence,\" the age-related decline of the immune system.\u003c\/p\u003e\n\u003chr data-path-to-node=\"28\"\u003e\n\u003ch3 data-path-to-node=\"29\"\u003e\u003cb data-path-to-node=\"29\" data-index-in-node=\"0\"\u003eStorage \u0026amp; Handling\u003c\/b\u003e\u003c\/h3\u003e\n\u003cul data-path-to-node=\"30\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"30,0,0\"\u003e\u003cb data-path-to-node=\"30,0,0\" data-index-in-node=\"0\"\u003ePhysical State:\u003c\/b\u003e Lyophilized (Freeze-Dried) White Powder.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"30,1,0\"\u003e\u003cb data-path-to-node=\"30,1,0\" data-index-in-node=\"0\"\u003eStorage (Powder):\u003c\/b\u003e Store at -20°C (Freezer). Stable for up to 36 months.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"30,2,0\"\u003e\u003cb data-path-to-node=\"30,2,0\" data-index-in-node=\"0\"\u003eReconstitution:\u003c\/b\u003e\u003c\/p\u003e\n\u003cul data-path-to-node=\"30,2,1\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"30,2,1,0,0\"\u003e\u003cb data-path-to-node=\"30,2,1,0,0\" data-index-in-node=\"0\"\u003eSolvent:\u003c\/b\u003e Sterile Water or Bacteriostatic Water.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"30,2,1,1,0\"\u003e\u003cb data-path-to-node=\"30,2,1,1,0\" data-index-in-node=\"0\"\u003eSolubility:\u003c\/b\u003e Highly soluble.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"30,3,0\"\u003e\u003cb data-path-to-node=\"30,3,0\" data-index-in-node=\"0\"\u003eStorage (Liquid):\u003c\/b\u003e Store at 4°C (Refrigerator). \u003cb data-path-to-node=\"30,3,0\" data-index-in-node=\"47\"\u003eUse within 7-14 days.\u003c\/b\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003chr data-path-to-node=\"31\"\u003e\n\u003ch3 data-path-to-node=\"32\"\u003e\u003cb data-path-to-node=\"32\" data-index-in-node=\"0\"\u003eDisclaimer\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp data-path-to-node=\"33\"\u003e\u003cb data-path-to-node=\"33\" data-index-in-node=\"0\"\u003eFOR RESEARCH USE ONLY.\u003c\/b\u003e This product is a chemical compound intended strictly for laboratory research and development. It is not approved by the FDA for clinical use, diagnostics, or therapeutic procedures in humans or animals. The physiological and toxicological properties of this chemical have not been fully investigated.\u003c\/p\u003e","brand":"Peptagon","offers":[{"title":"Default Title","offer_id":47712651280598,"sku":"TA1-10","price":38.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0783\/3085\/5638\/files\/Thymosin-Alpha-1-Peptide-_Thymalfasin_-10mg.png?v=1768836488"},{"product_id":"tb-500-thymosin-beta-4-research-peptide","title":"Thymosin Beta 4 Research Peptide – 10mg","description":"\u003ch4 data-path-to-node=\"13\"\u003e\u003cstrong\u003eTB-500 Peptide (Lyophilized)\u003c\/strong\u003e\u003c\/h4\u003e\n\u003cp data-path-to-node=\"14\"\u003e\u003cb data-path-to-node=\"14\" data-index-in-node=\"0\"\u003eSequence:\u003c\/b\u003e Ac-Ser-Asp-Lys-Pro-Asp-Met-Ala-Glu-Ile-Glu-Lys-Phe-Asp-Lys-Ser-Lys-Leu-Lys-Lys-Thr-Glu-Thr-Gln-Glu-Lys-Asn-Pro-Leu-Pro-Ser-Lys-Glu-Thr-Ile-Glu-Gln-Glu-Lys-Gln-Ala-Gly-Glu-Ser-OH \u003cb data-path-to-node=\"14\" data-index-in-node=\"188\"\u003eFormat:\u003c\/b\u003e Sterile Lyophilized Powder (Vial) \u003cb data-path-to-node=\"14\" data-index-in-node=\"230\"\u003eClass:\u003c\/b\u003e G-Actin Sequestering Peptide \u003cb data-path-to-node=\"14\" data-index-in-node=\"266\"\u003ePurity:\u003c\/b\u003e \u0026gt;98% (HPLC) \u003cb data-path-to-node=\"14\" data-index-in-node=\"286\"\u003eContent:\u003c\/b\u003e 5mg or 10mg per vial\u003c\/p\u003e\n\u003chr data-path-to-node=\"15\"\u003e\n\u003ch3 data-path-to-node=\"16\"\u003e\u003cb data-path-to-node=\"16\" data-index-in-node=\"0\"\u003eProduct Overview\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp data-path-to-node=\"17\"\u003e\u003cb data-path-to-node=\"17\" data-index-in-node=\"0\"\u003eTB-500\u003c\/b\u003e is a synthetic version of the naturally occurring peptide \u003cb data-path-to-node=\"17\" data-index-in-node=\"65\"\u003eThymosin Beta-4 (Tβ4)\u003c\/b\u003e. Found in high concentrations in almost all tissue types, Tβ4 is the primary molecule responsible for regulating cytoskeletal dynamics via G-actin sequestration.\u003c\/p\u003e\n\u003cp data-path-to-node=\"18\"\u003eTB-500 is widely researched for its potent regenerative capabilities. By maintaining the pool of actin monomers required for cell motility, it facilitates rapid tissue repair, angiogenesis (new blood vessel formation), and the modulation of inflammation in skin, heart, and neural tissues.\u003c\/p\u003e\n\u003chr data-path-to-node=\"19\"\u003e\n\u003ch3 data-path-to-node=\"20\"\u003e\u003cb data-path-to-node=\"20\" data-index-in-node=\"0\"\u003eMechanism of Action: The Cellular Architect\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp data-path-to-node=\"21\"\u003eTB-500 operates through distinct intracellular and extracellular pathways to drive regeneration.\u003c\/p\u003e\n\u003cul data-path-to-node=\"22\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"22,0,0\"\u003e\u003cb data-path-to-node=\"22,0,0\" data-index-in-node=\"0\"\u003eG-Actin Sequestration:\u003c\/b\u003e The peptide contains a conserved \u003cb data-path-to-node=\"22,0,0\" data-index-in-node=\"56\"\u003eLKKTET\u003c\/b\u003e motif that binds to G-actin (monomeric actin). This prevents premature polymerization, maintaining a \"ready pool\" of actin monomers essential for rapid cell migration and wound closure.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"22,1,0\"\u003e\u003cb data-path-to-node=\"22,1,0\" data-index-in-node=\"0\"\u003eNotch \u0026amp; VEGF Signaling:\u003c\/b\u003e Upregulates \u003cb data-path-to-node=\"22,1,0\" data-index-in-node=\"36\"\u003eNotch1\u003c\/b\u003e and \u003cb data-path-to-node=\"22,1,0\" data-index-in-node=\"47\"\u003eHIF-1α\u003c\/b\u003e, promoting angiogenesis and vascular repair, particularly under hypoxic (low oxygen) conditions.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"22,2,0\"\u003e\u003cb data-path-to-node=\"22,2,0\" data-index-in-node=\"0\"\u003eInflammation Control:\u003c\/b\u003e Inhibits the \u003cb data-path-to-node=\"22,2,0\" data-index-in-node=\"35\"\u003eNF-κB pathway\u003c\/b\u003e, reducing the expression of pro-inflammatory cytokines like IL-8 and promoting the transition of macrophages to a pro-repair (M2) phenotype.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003chr data-path-to-node=\"23\"\u003e\n\u003ch3 data-path-to-node=\"24\"\u003e\u003cb data-path-to-node=\"24\" data-index-in-node=\"0\"\u003eKey Research Applications\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp data-path-to-node=\"25\"\u003e\u003cb data-path-to-node=\"25\" data-index-in-node=\"0\"\u003e1. Dermal Wound Healing\u003c\/b\u003e TB-500 significantly accelerates wound closure. Research in rat models demonstrates a \u003cb data-path-to-node=\"25\" data-index-in-node=\"110\"\u003e42% improvement in re-epithelialization\u003c\/b\u003e by day 4 and improved collagen organization, reducing scarring.\u003c\/p\u003e\n\u003cp data-path-to-node=\"26\"\u003e\u003cb data-path-to-node=\"26\" data-index-in-node=\"0\"\u003e2. Cardiovascular Regeneration\u003c\/b\u003e In models of myocardial infarction (heart attack), TB-500 administration reduces cardiac rupture and inflammatory infiltration. It reactivates embryonic coronary development programs, promoting the growth of new blood vessels in damaged heart tissue.\u003c\/p\u003e\n\u003cp data-path-to-node=\"27\"\u003e\u003cb data-path-to-node=\"27\" data-index-in-node=\"0\"\u003e3. Neuroprotection \u0026amp; Remyelination\u003c\/b\u003e Investigated for its ability to mobilize Oligodendrocyte Progenitor Cells (OPCs) in the brain. Studies show it can enhance functional recovery in models of demyelination and neurotrauma.\u003c\/p\u003e\n\u003chr data-path-to-node=\"28\"\u003e\n\u003ch3 data-path-to-node=\"29\"\u003e\u003cb data-path-to-node=\"29\" data-index-in-node=\"0\"\u003eStorage \u0026amp; Handling\u003c\/b\u003e\u003c\/h3\u003e\n\u003cul data-path-to-node=\"30\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"30,0,0\"\u003e\u003cb data-path-to-node=\"30,0,0\" data-index-in-node=\"0\"\u003ePhysical State:\u003c\/b\u003e Lyophilized (Freeze-Dried) White Powder.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"30,1,0\"\u003e\u003cb data-path-to-node=\"30,1,0\" data-index-in-node=\"0\"\u003eStorage (Powder):\u003c\/b\u003e Store at -20°C (Freezer). Stable for up to 3 weeks at room temperature, but long-term freezer storage is required.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"30,2,0\"\u003e\u003cb data-path-to-node=\"30,2,0\" data-index-in-node=\"0\"\u003eReconstitution:\u003c\/b\u003e\u003c\/p\u003e\n\u003cul data-path-to-node=\"30,2,1\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"30,2,1,0,0\"\u003e\u003cb data-path-to-node=\"30,2,1,0,0\" data-index-in-node=\"0\"\u003eSolvent:\u003c\/b\u003e Bacteriostatic Water (0.9% Benzyl Alcohol).\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"30,2,1,1,0\"\u003e\u003cb data-path-to-node=\"30,2,1,1,0\" data-index-in-node=\"0\"\u003eSolubility:\u003c\/b\u003e Highly soluble due to high glutamate\/lysine content.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"30,3,0\"\u003e\u003cb data-path-to-node=\"30,3,0\" data-index-in-node=\"0\"\u003eStorage (Liquid):\u003c\/b\u003e Store at 4°C (Refrigerator). \u003cb data-path-to-node=\"30,3,0\" data-index-in-node=\"47\"\u003eUse within 2-7 days.\u003c\/b\u003e\u003c\/p\u003e\n\u003cul data-path-to-node=\"30,3,1\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"30,3,1,0,0\"\u003e\u003ci data-path-to-node=\"30,3,1,0,0\" data-index-in-node=\"0\"\u003eNote:\u003c\/i\u003e For longer storage of reconstituted peptide, the addition of a carrier protein (0.1% HSA or BSA) is recommended to prevent degradation.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003chr data-path-to-node=\"31\"\u003e\n\u003ch3 data-path-to-node=\"32\"\u003e\u003cb data-path-to-node=\"32\" data-index-in-node=\"0\"\u003eDisclaimer\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp data-path-to-node=\"33\"\u003e\u003cb data-path-to-node=\"33\" data-index-in-node=\"0\"\u003eFOR RESEARCH USE ONLY.\u003c\/b\u003e This product is a chemical compound intended strictly for laboratory research and development. It is not approved by the FDA for clinical use, diagnostics, or therapeutic procedures in humans or animals. The physiological and toxicological properties of this chemical have not been fully investigated.\u003c\/p\u003e","brand":"Peptagon","offers":[{"title":"10mg","offer_id":47712656359638,"sku":"TB500-10","price":41.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0783\/3085\/5638\/files\/Thymosin-Beta-4-10mg_1.png?v=1778247602"},{"product_id":"5-amino-1mq-nnmt-inhibitor-research-tablets","title":"5-Amino-1MQ Research Tablets – 50mg – 60 Count","description":"\u003ch4 data-path-to-node=\"11\"\u003e\u003cstrong\u003e5-Amino-1-methylquinolinium (5-Amino-1MQ)\u003c\/strong\u003e\u003c\/h4\u003e\n\u003cp data-path-to-node=\"12\"\u003e\u003cb data-path-to-node=\"12\" data-index-in-node=\"0\"\u003eCore Molecule:\u003c\/b\u003e 5-amino-1-methylquinolin-1-ium \u003cb data-path-to-node=\"12\" data-index-in-node=\"46\"\u003eFormat:\u003c\/b\u003e Oral Tablets \u003cb data-path-to-node=\"12\" data-index-in-node=\"67\"\u003eMechanism:\u003c\/b\u003e Selective Nicotinamide N-methyltransferase (NNMT) Inhibitor \u003cb data-path-to-node=\"12\" data-index-in-node=\"138\"\u003ePurity:\u003c\/b\u003e ≥98% (HPLC) \u003cb data-path-to-node=\"12\" data-index-in-node=\"158\"\u003eSalt Form:\u003c\/b\u003e Iodide or Chloride\u003c\/p\u003e\n\u003chr data-path-to-node=\"13\"\u003e\n\u003ch3 data-path-to-node=\"14\"\u003e\u003cb data-path-to-node=\"14\" data-index-in-node=\"0\"\u003eProduct Overview\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp data-path-to-node=\"15\"\u003e\u003cb data-path-to-node=\"15\" data-index-in-node=\"0\"\u003e5-Amino-1MQ\u003c\/b\u003e is a first-in-class small molecule inhibitor designed to target \u003cb data-path-to-node=\"15\" data-index-in-node=\"76\"\u003eNicotinamide N-methyltransferase (NNMT)\u003c\/b\u003e, a cytosolic enzyme that acts as a master regulator of the cellular \"metabolic drain.\"\u003c\/p\u003e\n\u003cp data-path-to-node=\"16\"\u003eIn states of obesity and aging, NNMT is often overexpressed, leading to the excessive methylation and excretion of nicotinamide. By inhibiting this enzyme, 5-Amino-1MQ prevents the loss of these precursors, effectively redirecting them into the \u003cb data-path-to-node=\"16\" data-index-in-node=\"245\"\u003eNAD+ salvage pathway\u003c\/b\u003e. This results in elevated intracellular NAD+ levels, optimized mitochondrial function, and enhanced energy metabolism without affecting appetite or caloric intake.\u003c\/p\u003e\n\u003chr data-path-to-node=\"17\"\u003e\n\u003ch3 data-path-to-node=\"18\"\u003e\u003cb data-path-to-node=\"18\" data-index-in-node=\"0\"\u003eMechanism of Action: The NAD+ Preservation\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp data-path-to-node=\"19\"\u003e5-Amino-1MQ works by precisely blocking the catalytic pocket of the NNMT enzyme.\u003c\/p\u003e\n\u003cul data-path-to-node=\"20\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"20,0,0\"\u003e\u003cb data-path-to-node=\"20,0,0\" data-index-in-node=\"0\"\u003eMetabolic Rewiring:\u003c\/b\u003e By stopping the conversion of nicotinamide (NAM) into 1-methylnicotinamide (1-MNA), the cell is forced to recycle NAM into \u003cb data-path-to-node=\"20,0,0\" data-index-in-node=\"143\"\u003eNAD+\u003c\/b\u003e. This increases the activity of sirtuins (SIRT1) and PARPs, which are essential for DNA repair and longevity.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"20,1,0\"\u003e\u003cb data-path-to-node=\"20,1,0\" data-index-in-node=\"0\"\u003eLipogenesis Inhibition:\u003c\/b\u003e In adipose tissue, NNMT inhibition reduces lipid accumulation by \u003cb data-path-to-node=\"20,1,0\" data-index-in-node=\"89\"\u003eup to 70%\u003c\/b\u003e (in vitro), shifting the cell's priority from fat storage to energy expenditure.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"20,2,0\"\u003e\u003cb data-path-to-node=\"20,2,0\" data-index-in-node=\"0\"\u003eMuscle Stem Cell Rescue:\u003c\/b\u003e It has been shown to rejuvenate senescent muscle stem cells (muSCs), restoring the regenerative capacity of aged skeletal muscle and significantly increasing grip strength and torque in animal models.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003chr data-path-to-node=\"21\"\u003e\n\u003ch3 data-path-to-node=\"22\"\u003e\u003cb data-path-to-node=\"22\" data-index-in-node=\"0\"\u003eKey Research Applications\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp data-path-to-node=\"23\"\u003e\u003cb data-path-to-node=\"23\" data-index-in-node=\"0\"\u003e1. Metabolic Syndrome \u0026amp; Obesity\u003c\/b\u003e 5-Amino-1MQ is a primary candidate for researching weight loss that is independent of the central nervous system. In diet-induced obese models, it produced a \u003cb data-path-to-node=\"23\" data-index-in-node=\"190\"\u003e7-10% reduction in body weight\u003c\/b\u003e in just 11 days by increasing the basal metabolic rate.\u003c\/p\u003e\n\u003cp data-path-to-node=\"24\"\u003e\u003cb data-path-to-node=\"24\" data-index-in-node=\"0\"\u003e2. Muscle Regeneration \u0026amp; Sarcopenia\u003c\/b\u003e Investigated for its ability to reverse age-related muscle decline. Research demonstrates a \u003cb data-path-to-node=\"24\" data-index-in-node=\"128\"\u003e70% increase in peak torque\u003c\/b\u003e and a significant acceleration in healing following muscle injury in aged subjects.\u003c\/p\u003e\n\u003cp data-path-to-node=\"25\"\u003e\u003cb data-path-to-node=\"25\" data-index-in-node=\"0\"\u003e3. NAD+ Synergy\u003c\/b\u003e Because it \"plugs the leak\" of NAD+ precursors, 5-Amino-1MQ is frequently studied in combination with NAD+ boosters like NMN or NR to maximize cellular energy and mitochondrial health.\u003c\/p\u003e\n\u003cp data-path-to-node=\"26\"\u003e\u003cb data-path-to-node=\"26\" data-index-in-node=\"0\"\u003e4. Autoimmune Inflammation\u003c\/b\u003e Emerging research in conditions like Graves' orbitopathy shows that 5-Amino-1MQ can significantly reduce the production of pro-inflammatory cytokines (IL-6, IL-8) and suppress pathogenic tissue remodeling.\u003c\/p\u003e\n\u003chr data-path-to-node=\"27\"\u003e\n\u003ch3 data-path-to-node=\"28\"\u003e\u003cb data-path-to-node=\"28\" data-index-in-node=\"0\"\u003eStorage \u0026amp; Handling\u003c\/b\u003e\u003c\/h3\u003e\n\u003cul data-path-to-node=\"29\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"29,0,0\"\u003e\u003cb data-path-to-node=\"29,0,0\" data-index-in-node=\"0\"\u003ePhysical State:\u003c\/b\u003e Tablet form for precise experimental dosing.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"29,1,0\"\u003e\u003cb data-path-to-node=\"29,1,0\" data-index-in-node=\"0\"\u003eStorage:\u003c\/b\u003e Store in a cool, dry place. Long-term storage at -20°C is recommended to maintain maximum purity.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"29,2,0\"\u003e\u003cb data-path-to-node=\"29,2,0\" data-index-in-node=\"0\"\u003eStability:\u003c\/b\u003e Chemically stable at room temperature when protected from direct light and moisture.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003chr data-path-to-node=\"30\"\u003e\n\u003ch3 data-path-to-node=\"31\"\u003e\u003cb data-path-to-node=\"31\" data-index-in-node=\"0\"\u003eDisclaimer\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp data-path-to-node=\"32\"\u003e\u003cb data-path-to-node=\"32\" data-index-in-node=\"0\"\u003eFOR RESEARCH USE ONLY.\u003c\/b\u003e This product is a chemical compound intended strictly for laboratory research and development. It is not approved by the FDA for clinical use, diagnostics, or therapeutic procedures in humans or animals. The physiological and toxicological properties of this chemical have not been fully investigated.\u003c\/p\u003e","brand":"Peptagon","offers":[{"title":"50 mg (60 Tablets)","offer_id":47712684245206,"sku":"5A1-50x60","price":67.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0783\/3085\/5638\/files\/5-Amino-1mq-_50mg_-x-60-Tablets.png?v=1768836648"},{"product_id":"bpc-157-oral-500mcg-research-tablets","title":"BPC-157 Research Tablets – 500mcg – 30 Count","description":"\u003ch4 data-path-to-node=\"11\"\u003e\u003cstrong\u003eBPC-157 (Stable Gastric Pentadecapeptide)\u003c\/strong\u003e\u003c\/h4\u003e\n\u003cp data-path-to-node=\"12\"\u003e\u003cb data-path-to-node=\"12\" data-index-in-node=\"0\"\u003eSequence:\u003c\/b\u003e Gly-Glu-Pro-Pro-Pro-Gly-Lys-Pro-Ala-Asp-Asp-Ala-Gly-Leu-Val \u003cb data-path-to-node=\"12\" data-index-in-node=\"70\"\u003eFormat:\u003c\/b\u003e Oral Tablets (L-Arginine Salt) \u003cb data-path-to-node=\"12\" data-index-in-node=\"109\"\u003eClass:\u003c\/b\u003e Cytoprotective Regenerative Peptide \u003cb data-path-to-node=\"12\" data-index-in-node=\"152\"\u003ePurity:\u003c\/b\u003e ≥99% (HPLC) \u003cb data-path-to-node=\"12\" data-index-in-node=\"172\"\u003eContent:\u003c\/b\u003e 500mcg per tablet\u003c\/p\u003e\n\u003chr data-path-to-node=\"13\"\u003e\n\u003ch3 data-path-to-node=\"14\"\u003e\u003cb data-path-to-node=\"14\" data-index-in-node=\"0\"\u003eProduct Overview\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp data-path-to-node=\"15\"\u003e\u003cb data-path-to-node=\"15\" data-index-in-node=\"0\"\u003eBPC-157 (Body Protection Compound-157)\u003c\/b\u003e is a synthetic pentadecapeptide derived from a naturally occurring protein found in human gastric juice. It is a cornerstone of regenerative medicine research, recognized for its \"organoprotective\" capabilities across multiple physiological systems.\u003c\/p\u003e\n\u003cp data-path-to-node=\"16\"\u003eThis specific \u003cb data-path-to-node=\"16\" data-index-in-node=\"14\"\u003e500mcg Oral Formulation\u003c\/b\u003e utilizes the stable \u003cb data-path-to-node=\"16\" data-index-in-node=\"58\"\u003eL-Arginine salt form\u003c\/b\u003e. Unlike standard peptide acetate forms which degrade rapidly in the stomach, this specialized salt remains bioactive in gastric juice for over 24 hours. This makes it a premier tool for researching systemic tissue repair, gut-brain axis modulation, and the acceleration of musculoskeletal recovery via oral administration.\u003c\/p\u003e\n\u003chr data-path-to-node=\"17\"\u003e\n\u003ch3 data-path-to-node=\"18\"\u003e\u003cb data-path-to-node=\"18\" data-index-in-node=\"0\"\u003eMechanism of Action: The Cytoprotective Cascade\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp data-path-to-node=\"19\"\u003eBPC-157 operates by activating the body’s innate regenerative signaling pathways.\u003c\/p\u003e\n\u003cul data-path-to-node=\"20\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"20,0,0\"\u003e\u003cb data-path-to-node=\"20,0,0\" data-index-in-node=\"0\"\u003eAngiogenesis (VEGF Pathway):\u003c\/b\u003e Upregulates the expression of \u003cb data-path-to-node=\"20,0,0\" data-index-in-node=\"59\"\u003eVEGFR2\u003c\/b\u003e receptors (by \u0026gt;200%), triggering the formation of new blood vessels. This \"vascular rescue\" allows oxygen and nutrients to reach damaged tissues that traditionally have poor blood supply.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"20,1,0\"\u003e\u003cb data-path-to-node=\"20,1,0\" data-index-in-node=\"0\"\u003eGene Expression (EGR-1):\u003c\/b\u003e Rapidly stimulates \u003cb data-path-to-node=\"20,1,0\" data-index-in-node=\"44\"\u003eEarly Growth Response-1 (EGR-1)\u003c\/b\u003e, a master transcription factor that orchestrates the initial stages of the wound healing response.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"20,2,0\"\u003e\u003cb data-path-to-node=\"20,2,0\" data-index-in-node=\"0\"\u003eNitric Oxide (NO) Modulation:\u003c\/b\u003e Balances the NO system, acting as a buffer to maintain vascular integrity. It counteracts the damage caused by both excessive NO production and Nitric Oxide Synthase inhibition.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"20,3,0\"\u003e\u003cb data-path-to-node=\"20,3,0\" data-index-in-node=\"0\"\u003eFibroblast Activation:\u003c\/b\u003e Increases the expression of the \u003cb data-path-to-node=\"20,3,0\" data-index-in-node=\"55\"\u003eGrowth Hormone Receptor (GHR)\u003c\/b\u003e on tendon and ligament cells, making them hypersensitive to natural repair signals.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003chr data-path-to-node=\"21\"\u003e\n\u003ch3 data-path-to-node=\"22\"\u003e\u003cb data-path-to-node=\"22\" data-index-in-node=\"0\"\u003eKey Research Applications\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp data-path-to-node=\"23\"\u003e\u003cb data-path-to-node=\"23\" data-index-in-node=\"0\"\u003e1. Gastrointestinal Repair \u0026amp; IBD\u003c\/b\u003e Research focuses on its ability to heal gastric ulcers, internal fistulas, and \"leaky gut\" syndrome. It is the gold standard for investigating the reversal of mucosal damage caused by chronic NSAID use (e.g., Aspirin, Ibuprofen).\u003c\/p\u003e\n\u003cp data-path-to-node=\"24\"\u003e\u003cb data-path-to-node=\"24\" data-index-in-node=\"0\"\u003e2. Musculoskeletal Recovery\u003c\/b\u003e Investigated for its ability to dramatically accelerate the healing of tendons, ligaments, and muscle-to-bone reattachment. In animal models, BPC-157 has shown the ability to restore biomechanical strength to transected Achilles tendons.\u003c\/p\u003e\n\u003cp data-path-to-node=\"25\"\u003e\u003cb data-path-to-node=\"25\" data-index-in-node=\"0\"\u003e3. Neuroprotection \u0026amp; Gut-Brain Axis\u003c\/b\u003e By stabilizing the gut-brain axis, BPC-157 is researched for its ability to reduce brain edema after trauma and balance neurotransmitter systems (dopamine and serotonin), offering a potential model for treating neuroinflammatory conditions.\u003c\/p\u003e\n\u003chr data-path-to-node=\"26\"\u003e\n\u003ch3 data-path-to-node=\"27\"\u003e\u003cb data-path-to-node=\"27\" data-index-in-node=\"0\"\u003eStorage \u0026amp; Handling\u003c\/b\u003e\u003c\/h3\u003e\n\u003cul data-path-to-node=\"28\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"28,0,0\"\u003e\u003cb data-path-to-node=\"28,0,0\" data-index-in-node=\"0\"\u003ePhysical State:\u003c\/b\u003e Tablet form for stable oral research.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"28,1,0\"\u003e\u003cb data-path-to-node=\"28,1,0\" data-index-in-node=\"0\"\u003eStorage:\u003c\/b\u003e Store in a cool, dry place. The L-Arginine salt is stable at room temperature for several months.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"28,2,0\"\u003e\u003cb data-path-to-node=\"28,2,0\" data-index-in-node=\"0\"\u003eLong-Term Storage:\u003c\/b\u003e Store at 4°C (Refrigerator) to maintain maximum enzymatic resistance for up to 2 years.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003chr data-path-to-node=\"29\"\u003e\n\u003ch3 data-path-to-node=\"30\"\u003e\u003cb data-path-to-node=\"30\" data-index-in-node=\"0\"\u003eDisclaimer\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp data-path-to-node=\"31\"\u003e\u003cb data-path-to-node=\"31\" data-index-in-node=\"0\"\u003eFOR RESEARCH USE ONLY.\u003c\/b\u003e This product is a chemical compound intended strictly for laboratory research and development. It is not approved by the FDA for clinical use, diagnostics, or therapeutic procedures in humans or animals. The physiological and toxicological properties of this chemical have not been fully investigated.\u003c\/p\u003e","brand":"Peptagon","offers":[{"title":"Default Title","offer_id":47712685785302,"sku":"BPC157-500x30","price":79.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0783\/3085\/5638\/files\/BPC-157-_500mcg_-x-30-Tablets.png?v=1768835818"},{"product_id":"ibutamoren-mesylate-mk-677-25mg-research-tablets","title":"MK-677 Research Tablets – 25mg – 60 Count","description":"\u003ch4 data-path-to-node=\"11\"\u003e\u003cstrong\u003eMK-677 (Ibutamoren Mesylate): Orally Bioavailable GH Secretagogue\u003c\/strong\u003e\u003c\/h4\u003e\n\u003cp data-path-to-node=\"12\"\u003e\u003cb data-path-to-node=\"12\" data-index-in-node=\"0\"\u003eChemical Class:\u003c\/b\u003e Spiropiperidine \u003cb data-path-to-node=\"12\" data-index-in-node=\"32\"\u003eFormat:\u003c\/b\u003e Oral Tablets \u003cb data-path-to-node=\"12\" data-index-in-node=\"53\"\u003eMechanism:\u003c\/b\u003e Selective GHS-R1a (Ghrelin Receptor) Agonist \u003cb data-path-to-node=\"12\" data-index-in-node=\"109\"\u003ePurity:\u003c\/b\u003e ≥98% (HPLC) \u003cb data-path-to-node=\"12\" data-index-in-node=\"129\"\u003eHalf-Life:\u003c\/b\u003e ~24 hours (Pharmacodynamic impact)\u003c\/p\u003e\n\u003chr data-path-to-node=\"13\"\u003e\n\u003ch3 data-path-to-node=\"14\"\u003e\u003cb data-path-to-node=\"14\" data-index-in-node=\"0\"\u003eProduct Overview\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp data-path-to-node=\"15\"\u003e\u003cb data-path-to-node=\"15\" data-index-in-node=\"0\"\u003eIbutamoren Mesylate (MK-677)\u003c\/b\u003e is a potent, non-peptide, orally bioavailable agonist of the \u003cb data-path-to-node=\"15\" data-index-in-node=\"90\"\u003eGrowth Hormone Secretagogue Receptor (GHS-R1a)\u003c\/b\u003e. Developed as a stable alternative to injectable growth hormone-releasing peptides (GHRPs), MK-677 precisely mimics the action of the endogenous hormone \u003cb data-path-to-node=\"15\" data-index-in-node=\"290\"\u003eghrelin\u003c\/b\u003e.\u003c\/p\u003e\n\u003cp data-path-to-node=\"16\"\u003eUnlike exogenous HGH, which can suppress natural production, MK-677 amplifies the amplitude of endogenous growth hormone pulses. It is widely researched for its ability to restore youthful somatotropic function, reversing age-related muscle loss (sarcopenia), improving bone mineral density, and enhancing sleep architecture without the need for daily injections.\u003c\/p\u003e\n\u003chr data-path-to-node=\"17\"\u003e\n\u003ch3 data-path-to-node=\"18\"\u003e\u003cb data-path-to-node=\"18\" data-index-in-node=\"0\"\u003eMechanism of Action: The Ghrelin Mimetic\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp data-path-to-node=\"19\"\u003eMK-677 operates by engaging the hypothalamus and pituitary gland to optimize the GH-IGF-1 axis.\u003c\/p\u003e\n\u003cul data-path-to-node=\"20\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"20,0,0\"\u003e\u003cb data-path-to-node=\"20,0,0\" data-index-in-node=\"0\"\u003eReceptor Agonism:\u003c\/b\u003e Binds to \u003cb data-path-to-node=\"20,0,0\" data-index-in-node=\"27\"\u003eGHS-R1a\u003c\/b\u003e receptors with high affinity (Kd 0.4 nM). This triggers the \u003cb data-path-to-node=\"20,0,0\" data-index-in-node=\"95\"\u003eGq-PLC-IP3\u003c\/b\u003e signaling pathway, leading to a rapid release of intracellular calcium.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"20,1,0\"\u003e\u003cb data-path-to-node=\"20,1,0\" data-index-in-node=\"0\"\u003eGH Pulsatility:\u003c\/b\u003e Amplifies existing growth hormone pulses by stimulating GHRH neurons in the arcuate nucleus while simultaneously inhibiting somatostatin (the \"off switch\" for GH release).\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"20,2,0\"\u003e\u003cb data-path-to-node=\"20,2,0\" data-index-in-node=\"0\"\u003eIGF-1 Induction:\u003c\/b\u003e The resulting GH surges stimulate the liver to increase production of \u003cb data-path-to-node=\"20,2,0\" data-index-in-node=\"87\"\u003eIGF-1\u003c\/b\u003e and its binding proteins (IGFBP-3), providing sustained anabolic signaling over a 24-hour period.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"20,3,0\"\u003e\u003cb data-path-to-node=\"20,3,0\" data-index-in-node=\"0\"\u003eSleep Modulation:\u003c\/b\u003e Enhances \u003cb data-path-to-node=\"20,3,0\" data-index-in-node=\"27\"\u003eREM sleep\u003c\/b\u003e duration and Stage IV deep sleep by stabilizing the homeostatic sleep-wake cycle via hypothalamic signaling.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003chr data-path-to-node=\"21\"\u003e\n\u003ch3 data-path-to-node=\"22\"\u003e\u003cb data-path-to-node=\"22\" data-index-in-node=\"0\"\u003eKey Research Applications\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp data-path-to-node=\"23\"\u003e\u003cb data-path-to-node=\"23\" data-index-in-node=\"0\"\u003e1. Body Composition \u0026amp; Nitrogen Retention\u003c\/b\u003e Investigated for its powerful nitrogen-sparing effects. Research shows MK-677 can reverse protein catabolism induced by caloric restriction, leading to significant increases in \u003cb data-path-to-node=\"23\" data-index-in-node=\"218\"\u003efat-free mass (FFM)\u003c\/b\u003e over long-term protocols.\u003c\/p\u003e\n\u003cp data-path-to-node=\"24\"\u003e\u003cb data-path-to-node=\"24\" data-index-in-node=\"0\"\u003e2. Skeletal Health \u0026amp; Bone Remodeling\u003c\/b\u003e MK-677 activates the bone remodeling cycle. Clinical studies in obese and elderly subjects demonstrate significant increases in bone turnover markers, including serum osteocalcin and procollagen III peptide.\u003c\/p\u003e\n\u003cp data-path-to-node=\"25\"\u003e\u003cb data-path-to-node=\"25\" data-index-in-node=\"0\"\u003e3. Age-Related Recovery (Sarcopenia)\u003c\/b\u003e Studies in healthy older adults indicate that daily administration can restore GH and IGF-1 levels to those of healthy young adults, aiding in the maintenance of body cell mass and physical function during senescence.\u003c\/p\u003e\n\u003chr data-path-to-node=\"26\"\u003e\n\u003ch3 data-path-to-node=\"27\"\u003e\u003cb data-path-to-node=\"27\" data-index-in-node=\"0\"\u003eStorage \u0026amp; Handling\u003c\/b\u003e\u003c\/h3\u003e\n\u003cul data-path-to-node=\"28\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"28,0,0\"\u003e\u003cb data-path-to-node=\"28,0,0\" data-index-in-node=\"0\"\u003ePhysical State:\u003c\/b\u003e Tablet form for consistent oral research dosing.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"28,1,0\"\u003e\u003cb data-path-to-node=\"28,1,0\" data-index-in-node=\"0\"\u003eStorage:\u003c\/b\u003e Store in a cool, dry place away from direct sunlight.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"28,2,0\"\u003e\u003cb data-path-to-node=\"28,2,0\" data-index-in-node=\"0\"\u003eLong-Term Storage:\u003c\/b\u003e Store at -20°C (Freezer) to ensure maximum chemical stability.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"28,3,0\"\u003e\u003cb data-path-to-node=\"28,3,0\" data-index-in-node=\"0\"\u003eStability:\u003c\/b\u003e Highly stable at room temperature in desiccated tablet form.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003chr data-path-to-node=\"29\"\u003e\n\u003ch3 data-path-to-node=\"30\"\u003e\u003cb data-path-to-node=\"30\" data-index-in-node=\"0\"\u003eDisclaimer\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp data-path-to-node=\"31\"\u003e\u003cb data-path-to-node=\"31\" data-index-in-node=\"0\"\u003eFOR RESEARCH USE ONLY.\u003c\/b\u003e This product is a chemical compound intended strictly for laboratory research and development. It is not approved by the FDA for clinical use, diagnostics, or therapeutic procedures in humans or animals. The physiological and toxicological properties of this chemical have not been fully investigated.\u003c\/p\u003e","brand":"Peptagon","offers":[{"title":"Default Title","offer_id":47712709476566,"sku":"MK677-25x60","price":151.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0783\/3085\/5638\/files\/MK-677-_25mg_-x-60-Tablets.png?v=1768836708"},{"product_id":"dihexa-pnb-0408-hgf-c-met-research-tablets","title":"Dihexa Research Tablets – 8mg \/ 30mg – 30 Count","description":"\u003ch4 data-path-to-node=\"11\"\u003e\u003cstrong\u003eDihexa: The Synaptogenic Catalyst\u003c\/strong\u003e\u003c\/h4\u003e\n\u003cp data-path-to-node=\"12\"\u003e\u003cb data-path-to-node=\"12\" data-index-in-node=\"0\"\u003eCore Molecule:\u003c\/b\u003e N-hexanoic-tyrosine-isoleucine-(6) aminohexanoic amide \u003cb data-path-to-node=\"12\" data-index-in-node=\"70\"\u003eFormat:\u003c\/b\u003e Oral Tablets \u003cb data-path-to-node=\"12\" data-index-in-node=\"91\"\u003eClass:\u003c\/b\u003e HGF Mimetic \/ Neurorestorative Peptide \u003cb data-path-to-node=\"12\" data-index-in-node=\"137\"\u003ePurity:\u003c\/b\u003e ≥98% (HPLC) \u003cb data-path-to-node=\"12\" data-index-in-node=\"157\"\u003eTarget:\u003c\/b\u003e HGF\/c-Met Signaling Pathway\u003c\/p\u003e\n\u003chr data-path-to-node=\"13\"\u003e\n\u003ch3 data-path-to-node=\"14\"\u003e\u003cb data-path-to-node=\"14\" data-index-in-node=\"0\"\u003eProduct Overview\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp data-path-to-node=\"15\"\u003e\u003cb data-path-to-node=\"15\" data-index-in-node=\"0\"\u003eDihexa (PNB-0408)\u003c\/b\u003e is a first-in-class, orally active oligopeptide designed to repair and rebuild neural architecture. Originally developed as a stabilized analog of Angiotensin IV, Dihexa was engineered to overcome the blood-brain barrier (BBB) and provide a regenerative approach to neurological decline.\u003c\/p\u003e\n\u003cp data-path-to-node=\"16\"\u003eDihexa is widely recognized for its \"synaptogenic\" properties—the ability to create new, functional connections between neurons. Unlike traditional agents that merely manage symptoms, Dihexa targets the underlying loss of connectivity in the brain, making it a premier candidate for research into Alzheimer’s disease, Parkinson’s disease, and traumatic brain injury.\u003c\/p\u003e\n\u003chr data-path-to-node=\"17\"\u003e\n\u003ch3 data-path-to-node=\"18\"\u003e\u003cb data-path-to-node=\"18\" data-index-in-node=\"0\"\u003eMechanism of Action: Rebuilding the Neural Web\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp data-path-to-node=\"19\"\u003eDihexa operates by potentiation of the \u003cb data-path-to-node=\"19\" data-index-in-node=\"39\"\u003eHepatocyte Growth Factor (HGF)\u003c\/b\u003e and its receptor, \u003cb data-path-to-node=\"19\" data-index-in-node=\"88\"\u003ec-Met\u003c\/b\u003e.\u003c\/p\u003e\n\u003cul data-path-to-node=\"20\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"20,0,0\"\u003e\u003cb data-path-to-node=\"20,0,0\" data-index-in-node=\"0\"\u003eSynaptogenesis:\u003c\/b\u003e By allosterically modulating HGF, Dihexa triggers the \u003cb data-path-to-node=\"20,0,0\" data-index-in-node=\"70\"\u003ePI3K\/AKT\u003c\/b\u003e and \u003cb data-path-to-node=\"20,0,0\" data-index-in-node=\"83\"\u003eMAPK\/ERK\u003c\/b\u003e pathways. This initiates the formation of new dendritic spines and functional synapses.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"20,1,0\"\u003e\u003cb data-path-to-node=\"20,1,0\" data-index-in-node=\"0\"\u003eExceptional Potency:\u003c\/b\u003e In laboratory assays, Dihexa demonstrated a neurotrophic potency \u003cb data-path-to-node=\"20,1,0\" data-index-in-node=\"86\"\u003eseven orders of magnitude (10^7 times) greater than BDNF\u003c\/b\u003e (Brain-Derived Neurotrophic Factor).\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"20,2,0\"\u003e\u003cb data-path-to-node=\"20,2,0\" data-index-in-node=\"0\"\u003eStructural Maturity:\u003c\/b\u003e It promotes the development of mature \"mushroom\" spine morphologies, which are associated with stable, long-term memory storage and robust neurotransmission.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"20,3,0\"\u003e\u003cb data-path-to-node=\"20,3,0\" data-index-in-node=\"0\"\u003eNeuroprotection:\u003c\/b\u003e It reduces neuroinflammation by decreasing astrocyte and microglia activation while increasing anti-inflammatory cytokines like IL-10.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003chr data-path-to-node=\"21\"\u003e\n\u003ch3 data-path-to-node=\"22\"\u003e\u003cb data-path-to-node=\"22\" data-index-in-node=\"0\"\u003eKey Research Applications\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp data-path-to-node=\"23\"\u003e\u003cb data-path-to-node=\"23\" data-index-in-node=\"0\"\u003e1. Alzheimer’s \u0026amp; Cognitive Decline\u003c\/b\u003e Investigated for its ability to rescue cognitive function. In APP\/PS1 mouse models, Dihexa significantly improved spatial learning and learning memory, returning performance to levels indistinguishable from healthy controls.\u003c\/p\u003e\n\u003cp data-path-to-node=\"24\"\u003e\u003cb data-path-to-node=\"24\" data-index-in-node=\"0\"\u003e2. Parkinson’s \u0026amp; Motor Recovery\u003c\/b\u003e Research supported by the Michael J. Fox Foundation showed that Dihexa can completely restore motor function in preclinical models of Parkinson's by promoting the survival of dopaminergic neurons and recovering Tyrosine Hydroxylase (TH) levels.\u003c\/p\u003e\n\u003cp data-path-to-node=\"25\"\u003e\u003cb data-path-to-node=\"25\" data-index-in-node=\"0\"\u003e3. Peripheral Nerve Repair\u003c\/b\u003e Studies demonstrate that Dihexa accelerates recovery from peripheral nerve injuries (PNI), enhancing motor reinnervation and mitigating muscle atrophy following nerve transection.\u003c\/p\u003e\n\u003chr data-path-to-node=\"26\"\u003e\n\u003ch3 data-path-to-node=\"27\"\u003e\u003cb data-path-to-node=\"27\" data-index-in-node=\"0\"\u003eStorage \u0026amp; Handling\u003c\/b\u003e\u003c\/h3\u003e\n\u003cul data-path-to-node=\"28\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"28,0,0\"\u003e\u003cb data-path-to-node=\"28,0,0\" data-index-in-node=\"0\"\u003ePhysical State:\u003c\/b\u003e Tablet form for consistent oral research protocols.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"28,1,0\"\u003e\u003cb data-path-to-node=\"28,1,0\" data-index-in-node=\"0\"\u003eStorage:\u003c\/b\u003e Store in a cool, dry place.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"28,2,0\"\u003e\u003cb data-path-to-node=\"28,2,0\" data-index-in-node=\"0\"\u003eLong-Term Storage:\u003c\/b\u003e Store at -20°C (Freezer) to maintain maximum purity and resist peptidase degradation.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"28,3,0\"\u003e\u003cb data-path-to-node=\"28,3,0\" data-index-in-node=\"0\"\u003eStability:\u003c\/b\u003e Highly stable and resistant to the harsh environment of the gastrointestinal tract.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003chr data-path-to-node=\"29\"\u003e\n\u003ch3 data-path-to-node=\"30\"\u003e\u003cb data-path-to-node=\"30\" data-index-in-node=\"0\"\u003eDisclaimer\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp data-path-to-node=\"31\"\u003e\u003cb data-path-to-node=\"31\" data-index-in-node=\"0\"\u003eFOR RESEARCH USE ONLY.\u003c\/b\u003e This product is a chemical compound intended strictly for laboratory research and development. It is not approved by the FDA for clinical use, diagnostics, or therapeutic procedures in humans or animals. The physiological and toxicological properties of this chemical have not been fully investigated.\u003c\/p\u003e","brand":"Peptagon","offers":[{"title":"8mg","offer_id":48169997598934,"sku":"DIHEX-8x30","price":92.0,"currency_code":"USD","in_stock":true},{"title":"30mg","offer_id":48169997631702,"sku":null,"price":206.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0783\/3085\/5638\/files\/Dihexa-_8mg_-x-30-Tablets.png?v=1768837429"},{"product_id":"slu-pp-332-err-pan-agonist-research-tablets","title":"SLU-PP-332 Research Tablets – 250mcg \/ 1mg \/ 200mg – 60 Count","description":"\u003ch4 data-path-to-node=\"11\"\u003e\u003cstrong\u003eSLU-PP-332: The Mitochondrial Exercise Mimetic\u003c\/strong\u003e\u003c\/h4\u003e\n\u003cp data-path-to-node=\"12\"\u003e\u003cb data-path-to-node=\"12\" data-index-in-node=\"0\"\u003eChemical Name:\u003c\/b\u003e (E)-4-hydroxy-N'-(naphthalen-2-ylmethylene)benzohydrazide \u003cb data-path-to-node=\"12\" data-index-in-node=\"73\"\u003eFormat:\u003c\/b\u003e Oral Tablets \u003cb data-path-to-node=\"12\" data-index-in-node=\"94\"\u003eClass:\u003c\/b\u003e Estrogen-Related Receptor (ERR) Pan-Agonist \u003cb data-path-to-node=\"12\" data-index-in-node=\"145\"\u003ePurity:\u003c\/b\u003e ≥98% (HPLC) \u003cb data-path-to-node=\"12\" data-index-in-node=\"165\"\u003eTarget:\u003c\/b\u003e ERRα, ERRβ, and ERRγ Transcriptional Networks\u003c\/p\u003e\n\u003chr data-path-to-node=\"13\"\u003e\n\u003ch3 data-path-to-node=\"14\"\u003e\u003cb data-path-to-node=\"14\" data-index-in-node=\"0\"\u003eProduct Overview\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp data-path-to-node=\"15\"\u003e\u003cb data-path-to-node=\"15\" data-index-in-node=\"0\"\u003eSLU-PP-332\u003c\/b\u003e is a first-in-class small molecule designed to function as an \"exercise mimetic.\" Developed through a collaboration between Saint Louis University and Washington University, it acts as a potent pan-agonist of the \u003cb data-path-to-node=\"15\" data-index-in-node=\"224\"\u003eEstrogen-Related Receptor (ERR)\u003c\/b\u003e family.\u003c\/p\u003e\n\u003cp data-path-to-node=\"16\"\u003eUnlike standard weight-loss agents that target appetite, SLU-PP-332 operates directly on peripheral tissues. It induces a high-oxidative state in skeletal muscle, effectively \"tricking\" the body into simulating the systemic benefits of endurance training. It is a premier tool for researching the reversal of metabolic syndrome, obesity, and age-related physiological decline through direct transcriptional modulation.\u003c\/p\u003e\n\u003chr data-path-to-node=\"17\"\u003e\n\u003ch3 data-path-to-node=\"18\"\u003e\u003cb data-path-to-node=\"18\" data-index-in-node=\"0\"\u003eMechanism of Action: Transcriptional Fat Burning\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp data-path-to-node=\"19\"\u003eSLU-PP-332 bypasses mechanical work to activate the genetic programs associated with physical exertion.\u003c\/p\u003e\n\u003cul data-path-to-node=\"20\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"20,0,0\"\u003e\u003cb data-path-to-node=\"20,0,0\" data-index-in-node=\"0\"\u003eERR Activation:\u003c\/b\u003e Specifically targets \u003cb data-path-to-node=\"20,0,0\" data-index-in-node=\"37\"\u003eERRα\u003c\/b\u003e, the master regulator of mitochondrial biogenesis. It stabilizes the active conformation of the receptor, allowing for the recruitment of the co-activator \u003cb data-path-to-node=\"20,0,0\" data-index-in-node=\"197\"\u003ePGC-1α\u003c\/b\u003e.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"20,1,0\"\u003e\u003cb data-path-to-node=\"20,1,0\" data-index-in-node=\"0\"\u003eMitochondrial Overdrive:\u003c\/b\u003e Upregulates the \u003cb data-path-to-node=\"20,1,0\" data-index-in-node=\"41\"\u003ePdk4\u003c\/b\u003e gene, which switches cellular fuel preference from glucose to fatty acids. This results in a \u003cb data-path-to-node=\"20,1,0\" data-index-in-node=\"139\"\u003e2.5x increase in mitochondrial DNA\u003c\/b\u003e and enhanced ATP production within myocytes.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"20,2,0\"\u003e\u003cb data-path-to-node=\"20,2,0\" data-index-in-node=\"0\"\u003eTissue Remodeling:\u003c\/b\u003e Promotes the development of \u003cb data-path-to-node=\"20,2,0\" data-index-in-node=\"47\"\u003eType IIa oxidative muscle fibers\u003c\/b\u003e, which are highly resistant to fatigue.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"20,3,0\"\u003e\u003cb data-path-to-node=\"20,3,0\" data-index-in-node=\"0\"\u003eSTING Pathway Inhibition:\u003c\/b\u003e In aging models, it has been shown to shutdown the \u003cb data-path-to-node=\"20,3,0\" data-index-in-node=\"77\"\u003ecGAS-STING\u003c\/b\u003e inflammatory response, protecting vital organs like the kidneys from age-related decline.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003chr data-path-to-node=\"21\"\u003e\n\u003ch3 data-path-to-node=\"22\"\u003e\u003cb data-path-to-node=\"22\" data-index-in-node=\"0\"\u003eKey Research Applications\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp data-path-to-node=\"23\"\u003e\u003cb data-path-to-node=\"23\" data-index-in-node=\"0\"\u003e1. Endurance \u0026amp; Physical Performance\u003c\/b\u003e Investigated for its ability to dramatically enhance aerobic capacity. In animal models, subjects treated with SLU-PP-332 were able to run \u003cb data-path-to-node=\"23\" data-index-in-node=\"175\"\u003e70% longer and 45% further\u003c\/b\u003e on treadmill tests compared to controls, despite no increase in actual physical activity.\u003c\/p\u003e\n\u003cp data-path-to-node=\"24\"\u003e\u003cb data-path-to-node=\"24\" data-index-in-node=\"0\"\u003e2. Obesity \u0026amp; Metabolic Syndrome\u003c\/b\u003e Research in Diet-Induced Obesity (DIO) models shows a \u003cb data-path-to-node=\"24\" data-index-in-node=\"86\"\u003e12% reduction in total body weight\u003c\/b\u003e and a 10-fold reduction in fat accumulation. The weight loss is driven by a ~25% increase in whole-body fat oxidation and resting energy expenditure.\u003c\/p\u003e\n\u003cp data-path-to-node=\"25\"\u003e\u003cb data-path-to-node=\"25\" data-index-in-node=\"0\"\u003e3. Geroprotection (Kidney \u0026amp; Muscle)\u003c\/b\u003e Studies in aged mice demonstrate that SLU-PP-332 reverses podocyte loss in the kidney and reduces albuminuria. It also promotes human myotube formation and fiber diameter, offering a model for treating \u003cb data-path-to-node=\"25\" data-index-in-node=\"238\"\u003esarcopenia\u003c\/b\u003e and muscle atrophy.\u003c\/p\u003e\n\u003cp data-path-to-node=\"26\"\u003e\u003cb data-path-to-node=\"26\" data-index-in-node=\"0\"\u003e4. Cardiovascular Support\u003c\/b\u003e Investigated for its ability to improve ejection fraction and survival rates in models of heart failure by normalizing oxidative phosphorylation profiles without inducing pathological hypertrophy.\u003c\/p\u003e\n\u003chr data-path-to-node=\"27\"\u003e\n\u003ch3 data-path-to-node=\"28\"\u003e\u003cb data-path-to-node=\"28\" data-index-in-node=\"0\"\u003eStorage \u0026amp; Handling\u003c\/b\u003e\u003c\/h3\u003e\n\u003cul data-path-to-node=\"29\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"29,0,0\"\u003e\u003cb data-path-to-node=\"29,0,0\" data-index-in-node=\"0\"\u003ePhysical State:\u003c\/b\u003e Standardized oral tablets for precise experimental protocols.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"29,1,0\"\u003e\u003cb data-path-to-node=\"29,1,0\" data-index-in-node=\"0\"\u003eStorage:\u003c\/b\u003e Store in a cool, dry place away from direct light.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"29,2,0\"\u003e\u003cb data-path-to-node=\"29,2,0\" data-index-in-node=\"0\"\u003eLong-Term Storage:\u003c\/b\u003e Store at -20°C (Freezer) to maintain stability for up to 4 years.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"29,3,0\"\u003e\u003cb data-path-to-node=\"29,3,0\" data-index-in-node=\"0\"\u003eStability:\u003c\/b\u003e Highly stable in tablet form; the lyophilized powder is resistant to degradation at room temperature for up to 3 weeks during transit.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003chr data-path-to-node=\"30\"\u003e\n\u003ch3 data-path-to-node=\"31\"\u003e\u003cb data-path-to-node=\"31\" data-index-in-node=\"0\"\u003eDisclaimer\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp data-path-to-node=\"32\"\u003e\u003cb data-path-to-node=\"32\" data-index-in-node=\"0\"\u003eFOR RESEARCH USE ONLY.\u003c\/b\u003e This product is a chemical compound intended strictly for laboratory research and development. It is not approved by the FDA for clinical use, diagnostics, or therapeutic procedures in humans or animals. The physiological and toxicological properties of this chemical have not been fully investigated.\u003c\/p\u003e","brand":"Peptagon","offers":[{"title":"250mcg","offer_id":47712730317014,"sku":"SLU-250x60","price":47.0,"currency_code":"USD","in_stock":true},{"title":"1mg","offer_id":47712730349782,"sku":"SLU-1x60","price":70.0,"currency_code":"USD","in_stock":true},{"title":"200mg","offer_id":48153996853462,"sku":"SLU-200x60","price":47.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0783\/3085\/5638\/files\/SLU-PP-332-_250mcg_-x-60-Tablets.png?v=1768837142"},{"product_id":"tesofensine-ns2330-500mcg-research-tablets","title":"Tesofensine Research Tablets – 500mcg – 30 Count \/ 100 Count","description":"\u003ch4 data-path-to-node=\"11\"\u003e\u003cstrong\u003eTesofensine: The Triple Monoamine Modulator\u003c\/strong\u003e\u003c\/h4\u003e\n\u003cp data-path-to-node=\"12\"\u003e\u003cb data-path-to-node=\"12\" data-index-in-node=\"0\"\u003eChemical Name:\u003c\/b\u003e (1R,2R,3S,5S)-3-(3,4-dichlorophenyl)-2-(ethoxymethyl)-8-methyl-8-azabicyclo[3.2.1]octane \u003cb data-path-to-node=\"12\" data-index-in-node=\"104\"\u003eFormat:\u003c\/b\u003e Oral Tablets \u003cb data-path-to-node=\"12\" data-index-in-node=\"125\"\u003eClass:\u003c\/b\u003e SNDRI (Serotonin-Norepinephrine-Dopamine Reuptake Inhibitor) \u003cb data-path-to-node=\"12\" data-index-in-node=\"193\"\u003ePurity:\u003c\/b\u003e ≥99% (HPLC) \u003cb data-path-to-node=\"12\" data-index-in-node=\"213\"\u003eHalf-Life:\u003c\/b\u003e ~9 Days (Systemic)\u003c\/p\u003e\n\u003chr data-path-to-node=\"13\"\u003e\n\u003ch3 data-path-to-node=\"14\"\u003e\u003cb data-path-to-node=\"14\" data-index-in-node=\"0\"\u003eProduct Overview\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp data-path-to-node=\"15\"\u003e\u003cb data-path-to-node=\"15\" data-index-in-node=\"0\"\u003eTesofensine (NS2330)\u003c\/b\u003e is a novel, centrally acting triple monoamine reuptake inhibitor. Originally investigated for neurodegenerative conditions like Parkinson’s and Alzheimer’s, it was repurposed for metabolic research due to its profound effects on weight management and appetite suppression.\u003c\/p\u003e\n\u003cp data-path-to-node=\"16\"\u003eUnlike earlier agents that targeted only one or two neurotransmitters, Tesofensine simultaneously elevates \u003cb data-path-to-node=\"16\" data-index-in-node=\"107\"\u003eSerotonin, Norepinephrine, and Dopamine\u003c\/b\u003e in the synaptic cleft. This triple-action mechanism addresses the three pillars of metabolic optimization: increasing satiety, reducing food-seeking behavior, and enhancing the resting metabolic rate.\u003c\/p\u003e\n\u003chr data-path-to-node=\"17\"\u003e\n\u003ch3 data-path-to-node=\"18\"\u003e\u003cb data-path-to-node=\"18\" data-index-in-node=\"0\"\u003eMechanism of Action: Central Satiety \u0026amp; Thermogenesis\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp data-path-to-node=\"19\"\u003eTesofensine operates by modulating the chemical signals of hunger and energy expenditure in the brain.\u003c\/p\u003e\n\u003cul data-path-to-node=\"20\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"20,0,0\"\u003e\u003cb data-path-to-node=\"20,0,0\" data-index-in-node=\"0\"\u003eTriple Reuptake Inhibition:\u003c\/b\u003e Blocks the transporters for Serotonin (SERT), Norepinephrine (NET), and Dopamine (DAT).\u003c\/p\u003e\n\u003cul data-path-to-node=\"20,0,1\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"20,0,1,0,0\"\u003e\u003cb data-path-to-node=\"20,0,1,0,0\" data-index-in-node=\"0\"\u003eSerotonin:\u003c\/b\u003e Increases feelings of fullness and satiety via POMC neurons.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"20,0,1,1,0\"\u003e\u003cb data-path-to-node=\"20,0,1,1,0\" data-index-in-node=\"0\"\u003eNorepinephrine:\u003c\/b\u003e Stimulates adrenergic pathways to increase metabolic expenditure and fat oxidation.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"20,0,1,2,0\"\u003e\u003cb data-path-to-node=\"20,0,1,2,0\" data-index-in-node=\"0\"\u003eDopamine:\u003c\/b\u003e Normalizes reward circuitry, reducing the psychological drive for \"hedonic\" or compulsive eating.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"20,1,0\"\u003e\u003cb data-path-to-node=\"20,1,0\" data-index-in-node=\"0\"\u003eHypothalamic Silencing:\u003c\/b\u003e Research indicates that Tesofensine inhibits GABAergic neurons in the lateral hypothalamus (LH). Silencing these specific neurons reduces the initiation of feeding behaviors.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"20,2,0\"\u003e\u003cb data-path-to-node=\"20,2,0\" data-index-in-node=\"0\"\u003eNeurotrophic Support:\u003c\/b\u003e Chronic treatment has been shown to increase levels of \u003cb data-path-to-node=\"20,2,0\" data-index-in-node=\"77\"\u003eBrain-Derived Neurotrophic Factor (BDNF)\u003c\/b\u003e. This may help \"reset\" the biological body weight set-point and prevent the weight rebound common after caloric restriction.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003chr data-path-to-node=\"21\"\u003e\n\u003ch3 data-path-to-node=\"22\"\u003e\u003cb data-path-to-node=\"22\" data-index-in-node=\"0\"\u003eKey Research Applications\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp data-path-to-node=\"23\"\u003e\u003cb data-path-to-node=\"23\" data-index-in-node=\"0\"\u003e1. Clinical Obesity \u0026amp; Weight Loss\u003c\/b\u003e In Phase II trials (TIPO-1), the 500 mcg dose achieved a \u003cb data-path-to-node=\"23\" data-index-in-node=\"91\"\u003e9.2% weight loss\u003c\/b\u003e over 24 weeks—approximately double the efficacy of many traditional agents. Research focuses on its ability to target visceral and abdominal fat specifically.\u003c\/p\u003e\n\u003cp data-path-to-node=\"24\"\u003e\u003cb data-path-to-node=\"24\" data-index-in-node=\"0\"\u003e2. Metabolic Rate \u0026amp; Fat Oxidation\u003c\/b\u003e Investigated for its ability to increase resting energy expenditure. Respiration chamber studies show that Tesofensine can increase 24-hour fat oxidation by \u003cb data-path-to-node=\"24\" data-index-in-node=\"191\"\u003e18 grams\u003c\/b\u003e and boost nocturnal energy expenditure by \u003cb data-path-to-node=\"24\" data-index-in-node=\"242\"\u003e4.6%\u003c\/b\u003e.\u003c\/p\u003e\n\u003cp data-path-to-node=\"25\"\u003e\u003cb data-path-to-node=\"25\" data-index-in-node=\"0\"\u003e3. Hypothalamic Obesity \u0026amp; Rare Disorders\u003c\/b\u003e Studied for its potential in treating resistant forms of obesity, such as Prader-Willi Syndrome and hypothalamic obesity, where the brain’s hunger-regulating centers are fundamentally impaired.\u003c\/p\u003e\n\u003chr data-path-to-node=\"26\"\u003e\n\u003ch3 data-path-to-node=\"27\"\u003e\u003cb data-path-to-node=\"27\" data-index-in-node=\"0\"\u003eStorage \u0026amp; Handling\u003c\/b\u003e\u003c\/h3\u003e\n\u003cul data-path-to-node=\"28\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"28,0,0\"\u003e\u003cb data-path-to-node=\"28,0,0\" data-index-in-node=\"0\"\u003ePhysical State:\u003c\/b\u003e Oral tablets for precise research dosing.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"28,1,0\"\u003e\u003cb data-path-to-node=\"28,1,0\" data-index-in-node=\"0\"\u003eStorage:\u003c\/b\u003e Store in a cool, dry place.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"28,2,0\"\u003e\u003cb data-path-to-node=\"28,2,0\" data-index-in-node=\"0\"\u003eLong-Term Storage:\u003c\/b\u003e Store at -20°C (Freezer) to maintain maximum chemical stability.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"28,3,0\"\u003e\u003cb data-path-to-node=\"28,3,0\" data-index-in-node=\"0\"\u003eStability:\u003c\/b\u003e Highly lipophilic and stable at room temperature; however, it should be protected from light and moisture to prevent dealkylation.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003chr data-path-to-node=\"29\"\u003e\n\u003ch3 data-path-to-node=\"30\"\u003e\u003cb data-path-to-node=\"30\" data-index-in-node=\"0\"\u003eDisclaimer\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp data-path-to-node=\"31\"\u003e\u003cb data-path-to-node=\"31\" data-index-in-node=\"0\"\u003eFOR RESEARCH USE ONLY.\u003c\/b\u003e This product is a chemical compound intended strictly for laboratory research and development. It is not approved by the FDA for clinical use, diagnostics, or therapeutic procedures in humans or animals. The physiological and toxicological properties of this chemical have not been fully investigated.\u003c\/p\u003e","brand":"Peptagon","offers":[{"title":"30 Capsules","offer_id":47714815181014,"sku":"TESOF-500x30","price":165.0,"currency_code":"USD","in_stock":true},{"title":"100 Capsules","offer_id":47714815148246,"sku":"TESOF-500x100","price":413.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0783\/3085\/5638\/files\/Tesofensine-_500mcg_-x30Capsules.png?v=1778506379"},{"product_id":"atx-304-o-304-pan-ampk-research-tablets","title":"ATX-304 Research Tablets – 100mg – 60 Count","description":"\u003ch1 data-section-id=\"u3jv4h\" data-start=\"339\" data-end=\"348\"\u003eATX-304\u003c\/h1\u003e\n\u003cp data-start=\"350\" data-end=\"376\"\u003e\u003cstrong data-start=\"350\" data-end=\"376\"\u003eATX-304 (O-304 \/ O304)\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp data-start=\"378\" data-end=\"678\"\u003e\u003cstrong data-start=\"378\" data-end=\"396\"\u003eChemical Name:\u003c\/strong\u003e 4-chloro-N-(2-(4-chlorobenzyl)-3-oxo-2,3-dihydro-1,2,4-thiadiazol-5-yl)benzamide\u003cbr data-start=\"477\" data-end=\"480\"\u003e\u003cstrong data-start=\"480\" data-end=\"488\"\u003eCAS:\u003c\/strong\u003e 1261289-04-6\u003cbr data-start=\"501\" data-end=\"504\"\u003e\u003cstrong data-start=\"504\" data-end=\"526\"\u003eMolecular Formula:\u003c\/strong\u003e C16H11Cl2N3O2S\u003cbr data-start=\"541\" data-end=\"544\"\u003e\u003cstrong data-start=\"544\" data-end=\"565\"\u003eMolecular Weight:\u003c\/strong\u003e 380.25 g\/mol\u003cbr data-start=\"578\" data-end=\"581\"\u003e\u003cstrong data-start=\"581\" data-end=\"592\"\u003eFormat:\u003c\/strong\u003e Oral Tablets\u003cbr data-start=\"605\" data-end=\"608\"\u003e\u003cstrong data-start=\"608\" data-end=\"618\"\u003eClass:\u003c\/strong\u003e Direct Pan-AMPK Activator \/ Metabolic Signaling Modulator\u003c\/p\u003e\n\u003cp data-start=\"680\" data-end=\"769\"\u003e\u003cstrong data-start=\"680\" data-end=\"697\"\u003eIntended Use:\u003c\/strong\u003e For laboratory research purposes only. Not for human or veterinary use.\u003c\/p\u003e\n\u003chr data-start=\"771\" data-end=\"774\"\u003e\n\u003ch2 data-section-id=\"1p927wt\" data-start=\"776\" data-end=\"795\"\u003eProduct Overview\u003c\/h2\u003e\n\u003cp data-start=\"797\" data-end=\"1163\"\u003eATX-304, also referenced in scientific literature as O-304 or O304, is a synthetic heterocyclic small molecule investigated for its role as a direct pan-activator of AMP-activated protein kinase (AMPK). Despite being grouped alongside peptide-based research compounds in some commercial contexts, ATX-304 is not a peptide and does not contain an amino acid sequence.\u003c\/p\u003e\n\u003cp data-start=\"1165\" data-end=\"1533\"\u003eAMPK functions as a central regulator of cellular energy homeostasis, coordinating responses to intracellular energy availability, mitochondrial activity, and metabolic demand. ATX-304 is utilized in preclinical research settings to investigate AMPK-dependent signaling pathways, metabolic regulation, and cellular adaptation processes under varying energy conditions.\u003c\/p\u003e\n\u003chr data-start=\"1535\" data-end=\"1538\"\u003e\n\u003ch2 data-section-id=\"knt4ug\" data-start=\"1540\" data-end=\"1564\"\u003eWhy This Formulation?\u003c\/h2\u003e\n\u003cp data-start=\"1566\" data-end=\"1757\"\u003eATX-304 is characterized by its small-molecule structure and oral research applicability, distinguishing it from earlier AMPK modulators with limited systemic exposure or isoform specificity.\u003c\/p\u003e\n\u003cp data-start=\"1759\" data-end=\"2169\"\u003eUnlike indirect AMPK activators that rely on altering cellular energy ratios, ATX-304 has been investigated for direct interaction with the AMPK complex and sustained modulation of its signaling activity across multiple isoforms. This makes it suitable for research involving systemic metabolic signaling, hepatic lipid metabolism pathways, renal cellular stress models, and skeletal muscle energy utilization.\u003c\/p\u003e\n\u003chr data-start=\"2171\" data-end=\"2174\"\u003e\n\u003ch2 data-section-id=\"f00cis\" data-start=\"2176\" data-end=\"2223\"\u003eMechanism of Action: AMPK Pathway Modulation\u003c\/h2\u003e\n\u003cp data-start=\"2225\" data-end=\"2321\"\u003eATX-304 has been studied for its interaction with AMPK signaling and related metabolic pathways.\u003c\/p\u003e\n\u003cp data-start=\"2323\" data-end=\"2615\"\u003e\u003cstrong data-start=\"2323\" data-end=\"2346\"\u003ePan-AMPK Activation\u003c\/strong\u003e\u003cbr data-start=\"2346\" data-end=\"2349\"\u003eATX-304 is investigated as a direct activator of AMPK across multiple heterotrimeric isoforms. Research suggests that it may contribute to maintaining phosphorylation at the AMPK α-subunit Thr172 site, a key regulatory component required for AMPK signaling activity.\u003c\/p\u003e\n\u003cp data-start=\"2617\" data-end=\"2828\"\u003e\u003cstrong data-start=\"2617\" data-end=\"2637\"\u003ePP2C Interaction\u003c\/strong\u003e\u003cbr data-start=\"2637\" data-end=\"2640\"\u003ePreclinical studies propose that ATX-304 may limit dephosphorylation of activated AMPK by protein phosphatase 2C (PP2C), thereby supporting sustained AMPK signaling in experimental models.\u003c\/p\u003e\n\u003cp data-start=\"2830\" data-end=\"3103\"\u003e\u003cstrong data-start=\"2830\" data-end=\"2870\"\u003eACC Phosphorylation \u0026amp; Lipid Pathways\u003c\/strong\u003e\u003cbr data-start=\"2870\" data-end=\"2873\"\u003eActivated AMPK phosphorylates acetyl-CoA carboxylase (ACC), a regulatory enzyme involved in fatty acid metabolism. ATX-304 has been investigated in models examining shifts between lipid synthesis and fatty acid oxidation pathways.\u003c\/p\u003e\n\u003cp data-start=\"3105\" data-end=\"3353\"\u003e\u003cstrong data-start=\"3105\" data-end=\"3145\"\u003eMitochondrial Activity \u0026amp; Energy Flux\u003c\/strong\u003e\u003cbr data-start=\"3145\" data-end=\"3148\"\u003eATX-304 has been studied in relation to mitochondrial respiration, oxygen consumption, and metabolic flux, including research exploring cellular responses to altered energy demand and oxidative conditions.\u003c\/p\u003e\n\u003cp data-start=\"3355\" data-end=\"3706\"\u003e\u003cstrong data-start=\"3355\" data-end=\"3384\"\u003eTranscriptional Signaling\u003c\/strong\u003e\u003cbr data-start=\"3384\" data-end=\"3387\"\u003eDownstream effects associated with AMPK activation include transcriptional regulation of pathways related to mitochondrial biogenesis, oxidative metabolism, and cellular stress response. ATX-304 has been evaluated in models examining signaling pathways involving PGC-1α, sirtuins, and lipid metabolism-associated genes.\u003c\/p\u003e\n\u003chr data-start=\"3708\" data-end=\"3711\"\u003e\n\u003ch2 data-section-id=\"1hv24wg\" data-start=\"3713\" data-end=\"3742\"\u003ePreclinical Research Areas\u003c\/h2\u003e\n\u003cp data-start=\"3744\" data-end=\"3936\"\u003e\u003cstrong data-start=\"3744\" data-end=\"3786\"\u003e1. AMPK Signaling \u0026amp; Energy Homeostasis\u003c\/strong\u003e\u003cbr data-start=\"3786\" data-end=\"3789\"\u003eATX-304 is utilized in research investigating AMPK as a regulator of cellular energy balance, nutrient sensing, and metabolic pathway coordination.\u003c\/p\u003e\n\u003cp data-start=\"3938\" data-end=\"4189\"\u003e\u003cstrong data-start=\"3938\" data-end=\"3989\"\u003e2. Hepatic Metabolism \u0026amp; Lipid Regulation Models\u003c\/strong\u003e\u003cbr data-start=\"3989\" data-end=\"3992\"\u003ePreclinical studies have evaluated ATX-304 in models examining hepatic lipid accumulation, cholesterol transport, and metabolic signaling associated with steatotic liver conditions.\u003cbr data-start=\"4173\" data-end=\"4176\"\u003e(Reference 1)\u003c\/p\u003e\n\u003cp data-start=\"4191\" data-end=\"4450\"\u003e\u003cstrong data-start=\"4191\" data-end=\"4226\"\u003e3. Renal Cellular Stress Models\u003c\/strong\u003e\u003cbr data-start=\"4226\" data-end=\"4229\"\u003eATX-304 has been studied in experimental models involving cisplatin-induced cellular stress, with focus on AMPK-dependent metabolic activity, mitochondrial function, and injury-response signaling pathways.\u003cbr data-start=\"4434\" data-end=\"4437\"\u003e(Reference 2)\u003c\/p\u003e\n\u003cp data-start=\"4452\" data-end=\"4670\"\u003e\u003cstrong data-start=\"4452\" data-end=\"4502\"\u003e4. Glucose Metabolism \u0026amp; Microvascular Research\u003c\/strong\u003e\u003cbr data-start=\"4502\" data-end=\"4505\"\u003eO304\/ATX-304 has been investigated in models assessing glucose utilization, skeletal muscle metabolic activity, and microvascular perfusion dynamics.\u003cbr data-start=\"4654\" data-end=\"4657\"\u003e(Reference 3)\u003c\/p\u003e\n\u003cp data-start=\"4672\" data-end=\"4909\"\u003e\u003cstrong data-start=\"4672\" data-end=\"4729\"\u003e5. Mitochondrial Function \u0026amp; Oxidative Stress Research\u003c\/strong\u003e\u003cbr data-start=\"4729\" data-end=\"4732\"\u003eDue to its interaction with AMPK signaling, ATX-304 is relevant in research exploring mitochondrial biogenesis, oxidative metabolism, and cellular responses to metabolic stress.\u003c\/p\u003e\n\u003chr data-start=\"4911\" data-end=\"4914\"\u003e\n\u003ch2 data-section-id=\"tslb7o\" data-start=\"4916\" data-end=\"4938\"\u003eResearch Advantages\u003c\/h2\u003e\n\u003cul data-start=\"4940\" data-end=\"5241\"\u003e\n\u003cli data-section-id=\"1ohi70l\" data-start=\"4940\" data-end=\"4991\"\u003eDirect interaction with AMPK signaling pathways\u003c\/li\u003e\n\u003cli data-section-id=\"2c0tq0\" data-start=\"4992\" data-end=\"5041\"\u003ePan-isoform AMPK activity (α1 \/ α2 complexes)\u003c\/li\u003e\n\u003cli data-section-id=\"15tupwk\" data-start=\"5042\" data-end=\"5073\"\u003eOral research applicability\u003c\/li\u003e\n\u003cli data-section-id=\"vpf6ox\" data-start=\"5074\" data-end=\"5116\"\u003eSmall-molecule structure (non-peptide)\u003c\/li\u003e\n\u003cli data-section-id=\"rjs9s8\" data-start=\"5117\" data-end=\"5173\"\u003eSuitable for long-duration metabolic research models\u003c\/li\u003e\n\u003cli data-section-id=\"af8sxl\" data-start=\"5174\" data-end=\"5241\"\u003eInvestigated across hepatic, renal, and skeletal muscle systems\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003chr data-start=\"5243\" data-end=\"5246\"\u003e\n\u003ch2 data-section-id=\"x99kj9\" data-start=\"5248\" data-end=\"5269\"\u003eStorage \u0026amp; Handling\u003c\/h2\u003e\n\u003cp data-start=\"5271\" data-end=\"5337\"\u003e\u003cstrong data-start=\"5271\" data-end=\"5290\"\u003ePhysical State:\u003c\/strong\u003e Tablet form for oral research administration\u003c\/p\u003e\n\u003cp data-start=\"5339\" data-end=\"5403\"\u003e\u003cstrong data-start=\"5339\" data-end=\"5351\"\u003eStorage:\u003c\/strong\u003e Store in a cool, dry place away from direct light\u003c\/p\u003e\n\u003cp data-start=\"5405\" data-end=\"5551\"\u003e\u003cstrong data-start=\"5405\" data-end=\"5427\"\u003eLong-Term Storage:\u003c\/strong\u003e Refrigerated storage recommended for extended stability. Avoid excessive heat, moisture, and repeated exposure to open air.\u003c\/p\u003e\n\u003chr data-start=\"5553\" data-end=\"5556\"\u003e\n\u003ch2 data-section-id=\"1g5aw3h\" data-start=\"5558\" data-end=\"5571\"\u003eDisclaimer\u003c\/h2\u003e\n\u003cp data-start=\"6070\" data-end=\"6394\"\u003eFOR RESEARCH USE ONLY. This product is a chemical compound intended strictly for laboratory research and development. It is not approved by the FDA for clinical use, diagnostics, or therapeutic procedures in humans or animals. The physiological and toxicological properties of this chemical have not been fully investigated.\u003c\/p\u003e","brand":"Peptagon","offers":[{"title":"Default Title","offer_id":48170116415702,"sku":"ATX304-100x60","price":155.0,"currency_code":"USD","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0783\/3085\/5638\/files\/ATX-304_100mg_-60tablets.png?v=1777476847"},{"product_id":"flgr242-follistatin-analog-peptide-2-vials","title":"FLGR242 Research Peptide – 10mg – 2 Vials","description":"\u003ch1 data-section-id=\"p930gd\" data-start=\"316\" data-end=\"325\"\u003eFLGR242\u003c\/h1\u003e\n\u003cp data-start=\"327\" data-end=\"369\"\u003e\u003cstrong data-start=\"327\" data-end=\"367\"\u003eFLGR242 (Follistatin Analog Peptide)\u003c\/strong\u003e\u003c\/p\u003e\n\u003ch2 data-section-id=\"1qhk4i3\" data-start=\"593\" data-end=\"612\"\u003eSpecifications\u003c\/h2\u003e\n\u003cp data-start=\"613\" data-end=\"819\"\u003e\u003cstrong data-start=\"613\" data-end=\"633\"\u003eSequence Length:\u003c\/strong\u003e ~242 Amino Acid Analog (FSTL3-Derived)\u003cbr data-start=\"672\" data-end=\"675\"\u003e\u003cstrong data-start=\"675\" data-end=\"686\"\u003eFormat:\u003c\/strong\u003e Lyophilized Peptide\u003cbr data-start=\"706\" data-end=\"709\"\u003e\u003cstrong data-start=\"709\" data-end=\"722\"\u003eQuantity:\u003c\/strong\u003e 2 Vials per Unit\u003cbr data-start=\"739\" data-end=\"742\"\u003e\u003cstrong data-start=\"742\" data-end=\"752\"\u003eClass:\u003c\/strong\u003e TGF-β Superfamily Antagonist \/ Myostatin (GDF-8) Binding Protein\u003c\/p\u003e\n\u003cp data-start=\"821\" data-end=\"910\"\u003e\u003cstrong data-start=\"821\" data-end=\"838\"\u003eIntended Use:\u003c\/strong\u003e For laboratory research purposes only. Not for human or veterinary use.\u003c\/p\u003e\n\u003chr data-start=\"912\" data-end=\"915\"\u003e\n\u003ch2 data-section-id=\"53drpp\" data-start=\"917\" data-end=\"938\"\u003eProduct Overview\u003c\/h2\u003e\n\u003cp data-start=\"940\" data-end=\"1259\"\u003eFLGR242 is an experimental, research-grade peptide engineered as a follistatin-related analog derived from follistatin-like protein 3 (FSTL3). It is investigated for its interaction with members of the transforming growth factor-beta (TGF-β) superfamily, particularly myostatin (growth differentiation factor 8, GDF-8).\u003c\/p\u003e\n\u003cp data-start=\"1261\" data-end=\"1379\"\u003eEach unit includes two vials, supporting controlled experimental design and reproducibility across research workflows.\u003c\/p\u003e\n\u003cp data-start=\"1381\" data-end=\"1736\"\u003eFollistatin-family proteins function as extracellular binding proteins that regulate signaling by sequestering target ligands prior to receptor engagement. FLGR242 is utilized in preclinical research settings to examine ligand-receptor dynamics, signaling pathway modulation, and regulatory mechanisms associated with myostatin and related growth factors.\u003c\/p\u003e\n\u003cp data-start=\"1738\" data-end=\"1935\"\u003eThis compound is structurally designed to isolate key ligand-binding domains while incorporating modifications intended to support extended stability and activity in controlled experimental models.\u003c\/p\u003e\n\u003chr data-start=\"1937\" data-end=\"1940\"\u003e\n\u003ch2 data-section-id=\"1igq9jc\" data-start=\"1942\" data-end=\"1968\"\u003eWhy This Formulation?\u003c\/h2\u003e\n\u003cp data-start=\"1970\" data-end=\"2113\"\u003eFLGR242 is derived from follistatin-related protein frameworks but differs from native follistatin isoforms through targeted structural design.\u003c\/p\u003e\n\u003cp data-start=\"2115\" data-end=\"2200\"\u003eCompared to full-length endogenous follistatin variants, FLGR242 is investigated for:\u003c\/p\u003e\n\u003cul data-start=\"2202\" data-end=\"2458\"\u003e\n\u003cli data-section-id=\"r4jk8p\" data-start=\"2202\" data-end=\"2246\"\u003eModified ligand-binding domain structure\u003c\/li\u003e\n\u003cli data-section-id=\"rj5bru\" data-start=\"2247\" data-end=\"2304\"\u003ePotential for extended activity in preclinical models\u003c\/li\u003e\n\u003cli data-section-id=\"1je7wss\" data-start=\"2305\" data-end=\"2378\"\u003eMore controlled interaction with myostatin-related signaling pathways\u003c\/li\u003e\n\u003cli data-section-id=\"1uiny2m\" data-start=\"2379\" data-end=\"2458\"\u003eReduced non-specific ligand binding compared to broader endogenous proteins\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp data-start=\"2460\" data-end=\"2595\"\u003eThese characteristics support its use in research requiring prolonged observation of TGF-β signaling and controlled pathway modulation.\u003c\/p\u003e\n\u003chr data-start=\"2597\" data-end=\"2600\"\u003e\n\u003ch2 data-section-id=\"smvib3\" data-start=\"2602\" data-end=\"2654\"\u003eMechanism of Action: TGF-β Ligand Sequestration\u003c\/h2\u003e\n\u003cp data-start=\"2656\" data-end=\"2773\"\u003eFLGR242 has been studied for its role as an extracellular binding peptide interacting with TGF-β superfamily ligands.\u003c\/p\u003e\n\u003cp data-start=\"2775\" data-end=\"2991\"\u003e\u003cstrong data-start=\"2775\" data-end=\"2804\"\u003eMyostatin (GDF-8) Binding\u003c\/strong\u003e\u003cbr data-start=\"2804\" data-end=\"2807\"\u003eFLGR242 is investigated for its ability to bind mature myostatin dimers in the extracellular environment, limiting ligand availability for receptor interaction in experimental systems.\u003c\/p\u003e\n\u003cp data-start=\"2993\" data-end=\"3198\"\u003e\u003cstrong data-start=\"2993\" data-end=\"3020\"\u003eActRIIB Pathway Context\u003c\/strong\u003e\u003cbr data-start=\"3020\" data-end=\"3023\"\u003eBy sequestering myostatin, FLGR242 has been studied in relation to signaling pathways involving the activin type IIB receptor (ActRIIB), a central receptor in TGF-β signaling.\u003c\/p\u003e\n\u003cp data-start=\"3200\" data-end=\"3427\"\u003e\u003cstrong data-start=\"3200\" data-end=\"3232\"\u003eSmad2\/3 Signaling Modulation\u003c\/strong\u003e\u003cbr data-start=\"3232\" data-end=\"3235\"\u003eMyostatin signaling typically activates intracellular Smad2\/3 transcription factors. FLGR242 is evaluated in models examining changes in Smad pathway activation following ligand sequestration.\u003c\/p\u003e\n\u003cp data-start=\"3429\" data-end=\"3605\"\u003e\u003cstrong data-start=\"3429\" data-end=\"3464\"\u003ePI3K\/Akt\/mTOR Signaling Context\u003c\/strong\u003e\u003cbr data-start=\"3464\" data-end=\"3467\"\u003eDownstream pathways associated with cellular signaling and protein regulation are studied in relation to altered TGF-β pathway conditions.\u003c\/p\u003e\n\u003cp data-start=\"3607\" data-end=\"3846\"\u003e\u003cstrong data-start=\"3607\" data-end=\"3644\"\u003eLigand Specificity Considerations\u003c\/strong\u003e\u003cbr data-start=\"3644\" data-end=\"3647\"\u003eFollistatin-related proteins may also interact with activins and related ligands. FLGR242 is theorized to exhibit modified binding selectivity, though specificity profiles remain under investigation.\u003c\/p\u003e\n\u003chr data-start=\"3848\" data-end=\"3851\"\u003e\n\u003ch2 data-section-id=\"1k1p0ls\" data-start=\"3853\" data-end=\"3884\"\u003ePreclinical Research Areas\u003c\/h2\u003e\n\u003cp data-start=\"3886\" data-end=\"4040\"\u003e\u003cstrong data-start=\"3886\" data-end=\"3921\"\u003e1. Myostatin Signaling Research\u003c\/strong\u003e\u003cbr data-start=\"3921\" data-end=\"3924\"\u003eUsed in studies examining extracellular ligand regulation, receptor binding, and pathway modulation involving GDF-8.\u003c\/p\u003e\n\u003cp data-start=\"4042\" data-end=\"4208\"\u003e\u003cstrong data-start=\"4042\" data-end=\"4073\"\u003e2. TGF-β Pathway Modulation\u003c\/strong\u003e\u003cbr data-start=\"4073\" data-end=\"4076\"\u003eInvestigated in models exploring receptor activation, transcriptional signaling, and pathway crosstalk within the TGF-β superfamily.\u003c\/p\u003e\n\u003cp data-start=\"4210\" data-end=\"4396\"\u003e\u003cstrong data-start=\"4210\" data-end=\"4253\"\u003e3. Myoblast \u0026amp; Cellular Signaling Models\u003c\/strong\u003e\u003cbr data-start=\"4253\" data-end=\"4256\"\u003eEvaluated in vitro for its role in myoblast activity and differentiation-related signaling pathways.\u003c\/p\u003e\n\u003cp data-start=\"4398\" data-end=\"4589\"\u003e\u003cstrong data-start=\"4398\" data-end=\"4435\"\u003e4. Skeletal Muscle Biology Models\u003c\/strong\u003e\u003cbr data-start=\"4435\" data-end=\"4438\"\u003eUsed in preclinical models to study signaling pathways, fiber composition, and structural adaptation processes.\u003c\/p\u003e\n\u003cp data-start=\"4591\" data-end=\"4749\"\u003e\u003cstrong data-start=\"4591\" data-end=\"4639\"\u003e5. Metabolic \u0026amp; Adipogenic Signaling Research\u003c\/strong\u003e\u003cbr data-start=\"4639\" data-end=\"4642\"\u003eInvestigated in models examining interactions between myostatin signaling and metabolic pathway regulation.\u003c\/p\u003e\n\u003chr data-start=\"4751\" data-end=\"4754\"\u003e\n\u003ch2 data-section-id=\"ce0tqk\" data-start=\"4756\" data-end=\"4773\"\u003eApplications\u003c\/h2\u003e\n\u003cul data-start=\"4775\" data-end=\"4981\"\u003e\n\u003cli data-section-id=\"1supcmu\" data-start=\"4775\" data-end=\"4809\"\u003eIn vitro ligand-binding assays\u003c\/li\u003e\n\u003cli data-section-id=\"zhneeu\" data-start=\"4810\" data-end=\"4860\"\u003eReceptor interaction studies (ActRIIB pathway)\u003c\/li\u003e\n\u003cli data-section-id=\"1vnlx4c\" data-start=\"4861\" data-end=\"4897\"\u003eTGF-β signaling pathway analysis\u003c\/li\u003e\n\u003cli data-section-id=\"1i9yj6\" data-start=\"4898\" data-end=\"4942\"\u003eCell culture models (myoblast signaling)\u003c\/li\u003e\n\u003cli data-section-id=\"nu6t34\" data-start=\"4943\" data-end=\"4981\"\u003eIn vivo pathway modulation studies\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003chr data-start=\"4983\" data-end=\"4986\"\u003e\n\u003ch2 data-section-id=\"1jtb6ys\" data-start=\"4988\" data-end=\"5012\"\u003eResearch Advantages\u003c\/h2\u003e\n\u003cul data-start=\"5014\" data-end=\"5339\"\u003e\n\u003cli data-section-id=\"1m150rx\" data-start=\"5014\" data-end=\"5062\"\u003eFollistatin-derived ligand-binding structure\u003c\/li\u003e\n\u003cli data-section-id=\"4dm7dq\" data-start=\"5063\" data-end=\"5114\"\u003eInvestigated for targeted myostatin interaction\u003c\/li\u003e\n\u003cli data-section-id=\"1dst7vo\" data-start=\"5115\" data-end=\"5169\"\u003eApplicable to TGF-β superfamily signaling research\u003c\/li\u003e\n\u003cli data-section-id=\"ibor19\" data-start=\"5170\" data-end=\"5227\"\u003eDesigned for extended activity in experimental models\u003c\/li\u003e\n\u003cli data-section-id=\"13ucu4h\" data-start=\"5228\" data-end=\"5278\"\u003eSuitable for both in vitro and in vivo studies\u003c\/li\u003e\n\u003cli data-section-id=\"1ktme7s\" data-start=\"5279\" data-end=\"5339\"\u003eNon-antibody approach to extracellular ligand modulation\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003chr data-start=\"5341\" data-end=\"5344\"\u003e\n\u003ch2 data-section-id=\"1qk69px\" data-start=\"5346\" data-end=\"5369\"\u003eStorage \u0026amp; Handling\u003c\/h2\u003e\n\u003cp data-start=\"5371\" data-end=\"5412\"\u003e\u003cstrong data-start=\"5371\" data-end=\"5390\"\u003ePhysical State:\u003c\/strong\u003e Lyophilized peptide\u003c\/p\u003e\n\u003cp data-start=\"5414\" data-end=\"5477\"\u003e\u003cstrong data-start=\"5414\" data-end=\"5426\"\u003eStorage:\u003c\/strong\u003e Store in a cool, dry environment away from light\u003c\/p\u003e\n\u003cp data-start=\"5479\" data-end=\"5573\"\u003e\u003cstrong data-start=\"5479\" data-end=\"5498\"\u003eReconstitution:\u003c\/strong\u003e Use appropriate sterile laboratory solutions under controlled conditions\u003c\/p\u003e\n\u003cp data-start=\"5575\" data-end=\"5681\"\u003e\u003cstrong data-start=\"5575\" data-end=\"5597\"\u003eLong-Term Storage:\u003c\/strong\u003e Refrigeration recommended after reconstitution. Avoid repeated freeze-thaw cycles\u003c\/p\u003e\n\u003chr data-start=\"5683\" data-end=\"5686\"\u003e\n\u003ch2 data-section-id=\"9rcx7q\" data-start=\"5688\" data-end=\"5703\"\u003eDisclaimer\u003c\/h2\u003e\n\u003cp data-start=\"5705\" data-end=\"6029\"\u003eFOR RESEARCH USE ONLY. This product is a chemical compound intended strictly for laboratory research and development. It is not approved by the FDA for clinical use, diagnostics, or therapeutic procedures in humans or animals. The physiological and toxicological properties of this chemical have not been fully investigated.\u003c\/p\u003e","brand":"Peptagon","offers":[{"title":"Default Title","offer_id":48170167271638,"sku":"FLGR242-2X","price":631.0,"currency_code":"USD","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0783\/3085\/5638\/files\/FLGR24210mg-2pk_43b99dd8-f2e1-4159-a9dc-4cc8e8c67e33.png?v=1777487938"},{"product_id":"alpha-klotho-monoclonal-antibody-mab-2-vials","title":"α-Klotho Monoclonal Research Antibody – 10mcg – 2 Vials","description":"\u003ch1 data-section-id=\"16wv5b9\" data-start=\"305\" data-end=\"359\"\u003eα-Klotho Monoclonal Antibody (MAB) – 10mcg (2 Vials)\u003c\/h1\u003e\n\u003ch2 data-section-id=\"1qhk4i3\" data-start=\"361\" data-end=\"380\"\u003eSpecifications\u003c\/h2\u003e\n\u003cp data-start=\"381\" data-end=\"593\"\u003e\u003cstrong data-start=\"381\" data-end=\"392\"\u003eTarget:\u003c\/strong\u003e α-Klotho (KL1 \/ KL2 extracellular domains)\u003cbr data-start=\"435\" data-end=\"438\"\u003e\u003cstrong data-start=\"438\" data-end=\"449\"\u003eFormat:\u003c\/strong\u003e Monoclonal Antibody (IgG-based)\u003cbr data-start=\"481\" data-end=\"484\"\u003e\u003cstrong data-start=\"484\" data-end=\"497\"\u003eQuantity:\u003c\/strong\u003e 10mcg per vial (2 vials)\u003cbr data-start=\"522\" data-end=\"525\"\u003e\u003cstrong data-start=\"525\" data-end=\"535\"\u003eClass:\u003c\/strong\u003e Protein Interaction \/ Endocrine Signaling Research Tool\u003c\/p\u003e\n\u003cp data-start=\"595\" data-end=\"684\"\u003e\u003cstrong data-start=\"595\" data-end=\"612\"\u003eIntended Use:\u003c\/strong\u003e For laboratory research purposes only. Not for human or veterinary use.\u003c\/p\u003e\n\u003chr data-start=\"686\" data-end=\"689\"\u003e\n\u003ch2 data-section-id=\"53drpp\" data-start=\"691\" data-end=\"712\"\u003eProduct Overview\u003c\/h2\u003e\n\u003cp data-start=\"714\" data-end=\"940\"\u003eα-Klotho MAB is a research-grade monoclonal antibody designed to interact with the extracellular domains of the α-Klotho protein, a key regulator within the FGF23–Klotho signaling axis and broader endocrine signaling networks.\u003c\/p\u003e\n\u003cp data-start=\"942\" data-end=\"1077\"\u003eEach unit contains two vials (10mcg per vial), supporting controlled experimental design and reproducibility across research protocols.\u003c\/p\u003e\n\u003cp data-start=\"1079\" data-end=\"1477\"\u003eα-Klotho functions as a co-receptor protein that facilitates ligand-receptor interactions, particularly involving fibroblast growth factor 23 (FGF23) and FGFR complexes. Monoclonal antibodies targeting α-Klotho are utilized in preclinical research to investigate protein-protein interactions, receptor complex formation, and signaling pathway modulation in both soluble and membrane-bound contexts.\u003c\/p\u003e\n\u003cp data-start=\"1479\" data-end=\"1665\"\u003eThis antibody is applicable to studies involving renal signaling, mineral metabolism pathways, and cellular signaling processes associated with oxidative stress and endocrine regulation.\u003c\/p\u003e\n\u003chr data-start=\"1667\" data-end=\"1670\"\u003e\n\u003ch2 data-section-id=\"1msf7q0\" data-start=\"1672\" data-end=\"1695\"\u003eWhy This Antibody?\u003c\/h2\u003e\n\u003cp data-start=\"1697\" data-end=\"1896\"\u003eα-Klotho MAB is designed for high-specificity interaction with defined extracellular domains of the Klotho protein, enabling precise investigation of protein structure and signaling complex dynamics.\u003c\/p\u003e\n\u003cp data-start=\"1898\" data-end=\"1938\"\u003eThe monoclonal antibody format provides:\u003c\/p\u003e\n\u003cul data-start=\"1939\" data-end=\"2107\"\u003e\n\u003cli data-section-id=\"1s72ari\" data-start=\"1939\" data-end=\"2004\"\u003eConsistent binding specificity across experimental conditions\u003c\/li\u003e\n\u003cli data-section-id=\"1igudx3\" data-start=\"2005\" data-end=\"2046\"\u003eReliable targeting of KL1\/KL2 domains\u003c\/li\u003e\n\u003cli data-section-id=\"10k9fry\" data-start=\"2047\" data-end=\"2107\"\u003eUtility in both detection and functional pathway studies\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp data-start=\"2109\" data-end=\"2281\"\u003eThis makes it suitable for controlled analysis of Klotho protein interaction research, particularly within FGF23-dependent signaling systems and related endocrine pathways.\u003c\/p\u003e\n\u003chr data-start=\"2283\" data-end=\"2286\"\u003e\n\u003ch2 data-section-id=\"1gcermw\" data-start=\"2288\" data-end=\"2356\"\u003eMechanism of Action: Protein Interaction \u0026amp; Signaling Modulation\u003c\/h2\u003e\n\u003cp data-start=\"2358\" data-end=\"2489\"\u003eα-Klotho monoclonal antibodies are studied based on their interaction with structural and functional domains of the Klotho protein.\u003c\/p\u003e\n\u003cp data-start=\"2491\" data-end=\"2740\"\u003e\u003cstrong data-start=\"2491\" data-end=\"2522\"\u003eFGF23–Klotho Signaling Axis\u003c\/strong\u003e\u003cbr data-start=\"2522\" data-end=\"2525\"\u003eα-Klotho serves as an obligate co-receptor for FGF23, facilitating high-affinity binding to FGFR complexes. Antibody interaction may influence formation or stability of this signaling complex in experimental models.\u003c\/p\u003e\n\u003cp data-start=\"2742\" data-end=\"2962\"\u003e\u003cstrong data-start=\"2742\" data-end=\"2786\"\u003eExtracellular Domain Binding (KL1 \/ KL2)\u003c\/strong\u003e\u003cbr data-start=\"2786\" data-end=\"2789\"\u003eTargeting of extracellular domains allows investigation of both membrane-bound and soluble α-Klotho, supporting analysis of ligand binding and receptor interaction dynamics.\u003c\/p\u003e\n\u003cp data-start=\"2964\" data-end=\"3108\"\u003e\u003cstrong data-start=\"2964\" data-end=\"2994\"\u003eMAPK \/ ERK Pathway Context\u003c\/strong\u003e\u003cbr data-start=\"2994\" data-end=\"2997\"\u003eModulation of FGF23-dependent signaling has been evaluated in relation to downstream MAPK\/ERK pathway activity.\u003c\/p\u003e\n\u003cp data-start=\"3110\" data-end=\"3292\"\u003e\u003cstrong data-start=\"3110\" data-end=\"3141\"\u003eTGF-β Signaling Interaction\u003c\/strong\u003e\u003cbr data-start=\"3141\" data-end=\"3144\"\u003eα-Klotho has been studied in relation to TGF-β receptor pathways, providing a framework for examining Smad-mediated signaling and pathway crosstalk.\u003c\/p\u003e\n\u003cp data-start=\"3294\" data-end=\"3486\"\u003e\u003cstrong data-start=\"3294\" data-end=\"3335\"\u003eOxidative Stress \u0026amp; Cellular Signaling\u003c\/strong\u003e\u003cbr data-start=\"3335\" data-end=\"3338\"\u003eResearch involving α-Klotho includes investigation of pathways associated with oxidative stress response, including Nrf2 and FoxO signaling systems.\u003c\/p\u003e\n\u003chr data-start=\"3488\" data-end=\"3491\"\u003e\n\u003ch2 data-section-id=\"2op8d9\" data-start=\"3493\" data-end=\"3531\"\u003ePreclinical Research Applications\u003c\/h2\u003e\n\u003cp data-start=\"3533\" data-end=\"3664\"\u003e\u003cstrong data-start=\"3533\" data-end=\"3571\"\u003e1. FGF23–Klotho Signaling Research\u003c\/strong\u003e\u003cbr data-start=\"3571\" data-end=\"3574\"\u003eUsed to study receptor complex formation and signaling within mineral metabolism pathways.\u003c\/p\u003e\n\u003cp data-start=\"3666\" data-end=\"3822\"\u003e\u003cstrong data-start=\"3666\" data-end=\"3703\"\u003e2. Renal \u0026amp; Kidney Function Models\u003c\/strong\u003e\u003cbr data-start=\"3703\" data-end=\"3706\"\u003eApplied in preclinical models investigating α-Klotho expression, depletion, and signaling dynamics in renal systems.\u003c\/p\u003e\n\u003cp data-start=\"3824\" data-end=\"3990\"\u003e\u003cstrong data-start=\"3824\" data-end=\"3874\"\u003e3. Soluble α-Klotho Detection \u0026amp; Quantification\u003c\/strong\u003e\u003cbr data-start=\"3874\" data-end=\"3877\"\u003eUtilized in workflows involving immunoprecipitation, immunoblotting, and protein detection in biological samples.\u003c\/p\u003e\n\u003cp data-start=\"3992\" data-end=\"4126\"\u003e\u003cstrong data-start=\"3992\" data-end=\"4025\"\u003e4. Endocrine Signaling Models\u003c\/strong\u003e\u003cbr data-start=\"4025\" data-end=\"4028\"\u003eInvestigated in research involving systemic endocrine regulation and protein interaction networks.\u003c\/p\u003e\n\u003cp data-start=\"4128\" data-end=\"4247\"\u003e\u003cstrong data-start=\"4128\" data-end=\"4172\"\u003e5. Inflammation \u0026amp; NF-κB Pathway Research\u003c\/strong\u003e\u003cbr data-start=\"4172\" data-end=\"4175\"\u003eUsed in studies examining inflammatory signaling and pathway modulation.\u003c\/p\u003e\n\u003cp data-start=\"4249\" data-end=\"4384\"\u003e\u003cstrong data-start=\"4249\" data-end=\"4284\"\u003e6. Structural \u0026amp; Binding Studies\u003c\/strong\u003e\u003cbr data-start=\"4284\" data-end=\"4287\"\u003eSupports analysis of protein-protein interaction dynamics and receptor-ligand binding mechanisms.\u003c\/p\u003e\n\u003chr data-start=\"4386\" data-end=\"4389\"\u003e\n\u003ch2 data-section-id=\"ce0tqk\" data-start=\"4391\" data-end=\"4408\"\u003eApplications\u003c\/h2\u003e\n\u003cul data-start=\"4410\" data-end=\"4542\"\u003e\n\u003cli data-section-id=\"1iuqn3k\" data-start=\"4410\" data-end=\"4438\"\u003eImmunoprecipitation (IP)\u003c\/li\u003e\n\u003cli data-section-id=\"t1w30\" data-start=\"4439\" data-end=\"4472\"\u003eImmunoblotting (Western Blot)\u003c\/li\u003e\n\u003cli data-section-id=\"wtmzw9\" data-start=\"4473\" data-end=\"4503\"\u003eImmunohistochemistry (IHC)\u003c\/li\u003e\n\u003cli data-section-id=\"tund4r\" data-start=\"4504\" data-end=\"4542\"\u003eFlow Cytometry (variant dependent)\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003chr data-start=\"4544\" data-end=\"4547\"\u003e\n\u003ch2 data-section-id=\"1jtb6ys\" data-start=\"4549\" data-end=\"4573\"\u003eResearch Advantages\u003c\/h2\u003e\n\u003cul data-start=\"4575\" data-end=\"4910\"\u003e\n\u003cli data-section-id=\"1ltkoqj\" data-start=\"4575\" data-end=\"4630\"\u003eHigh specificity for α-Klotho extracellular domains\u003c\/li\u003e\n\u003cli data-section-id=\"18m2wvd\" data-start=\"4631\" data-end=\"4691\"\u003eApplicable to soluble and membrane-bound protein studies\u003c\/li\u003e\n\u003cli data-section-id=\"f0p27o\" data-start=\"4692\" data-end=\"4744\"\u003eSupports FGF23–Klotho signaling pathway analysis\u003c\/li\u003e\n\u003cli data-section-id=\"1cj8rdc\" data-start=\"4745\" data-end=\"4798\"\u003eCompatible with multiple laboratory assay systems\u003c\/li\u003e\n\u003cli data-section-id=\"1fwk0xb\" data-start=\"4799\" data-end=\"4858\"\u003eSuitable for protein interaction and signaling research\u003c\/li\u003e\n\u003cli data-section-id=\"dmxsnl\" data-start=\"4859\" data-end=\"4910\"\u003eNon-therapeutic, research-focused antibody tool\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003chr data-start=\"4912\" data-end=\"4915\"\u003e\n\u003ch2 data-section-id=\"1qk69px\" data-start=\"4917\" data-end=\"4940\"\u003eStorage \u0026amp; Handling\u003c\/h2\u003e\n\u003cp data-start=\"4942\" data-end=\"5035\"\u003e\u003cstrong data-start=\"4942\" data-end=\"4961\"\u003ePhysical State:\u003c\/strong\u003e Monoclonal antibody (solution or lyophilized format depending on batch)\u003c\/p\u003e\n\u003cp data-start=\"5037\" data-end=\"5085\"\u003e\u003cstrong data-start=\"5037\" data-end=\"5049\"\u003eStorage:\u003c\/strong\u003e Store at 2–8°C for short-term use\u003c\/p\u003e\n\u003cp data-start=\"5087\" data-end=\"5161\"\u003e\u003cstrong data-start=\"5087\" data-end=\"5109\"\u003eLong-Term Storage:\u003c\/strong\u003e Store at -20°C or below for extended preservation\u003c\/p\u003e\n\u003cp data-start=\"5163\" data-end=\"5241\"\u003e\u003cstrong data-start=\"5163\" data-end=\"5176\"\u003eHandling:\u003c\/strong\u003e Avoid repeated freeze-thaw cycles. Use aliquots where possible\u003c\/p\u003e\n\u003cp data-start=\"5243\" data-end=\"5305\"\u003e\u003cstrong data-start=\"5243\" data-end=\"5265\"\u003eLight Sensitivity:\u003c\/strong\u003e Protect from prolonged light exposure\u003c\/p\u003e\n\u003chr data-start=\"5307\" data-end=\"5310\"\u003e\n\u003ch2 data-section-id=\"9rcx7q\" data-start=\"5312\" data-end=\"5327\"\u003eDisclaimer\u003c\/h2\u003e\n\u003cp data-start=\"5329\" data-end=\"5653\"\u003eFOR RESEARCH USE ONLY. This product is a chemical compound intended strictly for laboratory research and development. It is not approved by the FDA for clinical use, diagnostics, or therapeutic procedures in humans or animals. The physiological and toxicological properties of this chemical have not been fully investigated.\u003c\/p\u003e","brand":"Peptagon","offers":[{"title":"Default Title","offer_id":48170187653334,"sku":"KLOTH-10-X2","price":631.0,"currency_code":"USD","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0783\/3085\/5638\/files\/a-KlothoMAB2pk_ca536a91-1d43-4247-a8e7-6c1adfdcbb94.png?v=1777487807"}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0783\/3085\/5638\/collections\/Research_Peptides_Collection.png?v=1779288765","url":"https:\/\/peptagon.com\/collections\/research-peptides.oembed","provider":"Peptagon","version":"1.0","type":"link"}