{"title":"Tissue \u0026 Extracellular Matrix Research","description":"\u003cp\u003eThis collection includes research peptides and peptide-based formulations studied in laboratory models involving extracellular matrix signaling, structural protein pathways, tissue-response processes, and related cellular systems.\u003c\/p\u003e\n\u003cp\u003eProducts in this collection may include lyophilized research peptides, oral research formulations, and multi-compound peptide blends. Each product is organized for research cataloging purposes only and is intended strictly for qualified laboratory research use.\u003c\/p\u003e\n\u003cp\u003eThese products are not dietary supplements, medications, cosmetics, or consumer health products, and are not for human or veterinary use.\u003c\/p\u003e","products":[{"product_id":"ara-290-cibinetide-research-peptide","title":"ARA-290 Research Peptide – 14mg","description":"\u003ch4 data-path-to-node=\"13\"\u003e\u003cstrong\u003eARA-290 (Cibinetide) Peptide (Lyophilized)\u003c\/strong\u003e\u003c\/h4\u003e\n\u003cp data-path-to-node=\"14\"\u003e\u003cb data-path-to-node=\"14\" data-index-in-node=\"0\"\u003eSequence:\u003c\/b\u003e Glp-Glu-Gln-Leu-Glu-Arg-Ala-Leu-Asn-Ser-Ser \u003cb data-path-to-node=\"14\" data-index-in-node=\"54\"\u003eFormat:\u003c\/b\u003e Sterile Lyophilized Powder (Vial) \u003cb data-path-to-node=\"14\" data-index-in-node=\"96\"\u003eConfiguration:\u003c\/b\u003e Linear 11-mer (Pyroglutamate Modified) \u003cb data-path-to-node=\"14\" data-index-in-node=\"150\"\u003ePurity:\u003c\/b\u003e \u0026gt;99% (HPLC) \u003cb data-path-to-node=\"14\" data-index-in-node=\"170\"\u003eContent:\u003c\/b\u003e 14mg per vial\u003c\/p\u003e\n\u003chr data-path-to-node=\"15\"\u003e\n\u003ch3 data-path-to-node=\"16\"\u003e\u003cb data-path-to-node=\"16\" data-index-in-node=\"0\"\u003eProduct Overview\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp data-path-to-node=\"17\"\u003e\u003cb data-path-to-node=\"17\" data-index-in-node=\"0\"\u003eARA-290\u003c\/b\u003e, scientifically known as Cibinetide or Pyroglutamate Helix B Surface Peptide (pHBSP), is a synthetic 11-amino acid peptide engineered to harness the tissue-repair capabilities of Erythropoietin (EPO) without its blood-building side effects.\u003c\/p\u003e\n\u003cp data-path-to-node=\"18\"\u003eBy mimicking the 3D topography of EPO's Helix-B domain, ARA-290 acts as a highly selective agonist for the \u003cb data-path-to-node=\"18\" data-index-in-node=\"107\"\u003eInnate Repair Receptor (IRR)\u003c\/b\u003e. This receptor is transiently expressed only during tissue stress or injury. Consequently, ARA-290 activates potent anti-inflammatory and cytoprotective pathways selectively in damaged tissue, making it a primary subject of research for Small Fiber Neuropathy (SFN), Sarcoidosis, and metabolic dysregulation.\u003c\/p\u003e\n\u003chr data-path-to-node=\"19\"\u003e\n\u003ch3 data-path-to-node=\"20\"\u003e\u003cb data-path-to-node=\"20\" data-index-in-node=\"0\"\u003eMechanism of Action: Selective IRR Activation\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp data-path-to-node=\"21\"\u003eThe pharmacological value of ARA-290 lies in its receptor selectivity. It decouples the two primary functions of EPO:\u003c\/p\u003e\n\u003cul data-path-to-node=\"22\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"22,0,0\"\u003e\u003cb data-path-to-node=\"22,0,0\" data-index-in-node=\"0\"\u003eNo Hematopoietic Effect:\u003c\/b\u003e ARA-290 does \u003ci data-path-to-node=\"22,0,0\" data-index-in-node=\"38\"\u003enot\u003c\/i\u003e bind to the homodimeric EPO receptor (EPOR\/EPOR) responsible for red blood cell production. Therefore, it does not increase hematocrit or blood viscosity.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"22,1,0\"\u003e\u003cb data-path-to-node=\"22,1,0\" data-index-in-node=\"0\"\u003eTargeted Tissue Repair:\u003c\/b\u003e ARA-290 binds exclusively to the \u003cb data-path-to-node=\"22,1,0\" data-index-in-node=\"57\"\u003eInnate Repair Receptor (EPOR\/CD131)\u003c\/b\u003e. Activation of this complex triggers the downregulation of NF-κB (the master inflammatory switch) and the upregulation of SIRT1.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003chr data-path-to-node=\"23\"\u003e\n\u003ch3 data-path-to-node=\"24\"\u003e\u003cb data-path-to-node=\"24\" data-index-in-node=\"0\"\u003eKey Research Applications\u003c\/b\u003e\u003c\/h3\u003e\n\u003ch4 data-path-to-node=\"25\"\u003e\u003cb data-path-to-node=\"25\" data-index-in-node=\"0\"\u003e1. Small Fiber Neuropathy (SFN) \u0026amp; Neuroregeneration\u003c\/b\u003e\u003c\/h4\u003e\n\u003cp data-path-to-node=\"26\"\u003eARA-290 is unique in its ability to promote the structural regrowth of nerves.\u003c\/p\u003e\n\u003cul data-path-to-node=\"27\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"27,0,0\"\u003e\u003cb data-path-to-node=\"27,0,0\" data-index-in-node=\"0\"\u003eMechanism:\u003c\/b\u003e By suppressing perineural inflammation (TNF-α suppression) and shifting microglia to a reparative phenotype, it creates an environment permissive for axonal sprouting.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"27,1,0\"\u003e\u003cb data-path-to-node=\"27,1,0\" data-index-in-node=\"0\"\u003eClinical Evidence:\u003c\/b\u003e In Phase 2 trials involving Sarcoidosis patients, ARA-290 administration resulted in a significant increase in \u003cb data-path-to-node=\"27,1,0\" data-index-in-node=\"130\"\u003eCorneal Nerve Fiber Density (CNFD)\u003c\/b\u003e, providing objective anatomical proof of nerve regeneration.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch4 data-path-to-node=\"28\"\u003e\u003cb data-path-to-node=\"28\" data-index-in-node=\"0\"\u003e2. Chronic Inflammation \u0026amp; Autoimmunity\u003c\/b\u003e\u003c\/h4\u003e\n\u003cp data-path-to-node=\"29\"\u003eThe peptide targets the \u003cb data-path-to-node=\"29\" data-index-in-node=\"24\"\u003eSIRT1 \/ NF-κB Axis\u003c\/b\u003e.\u003c\/p\u003e\n\u003cul data-path-to-node=\"30\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"30,0,0\"\u003e\u003cb data-path-to-node=\"30,0,0\" data-index-in-node=\"0\"\u003eAction:\u003c\/b\u003e It reduces the acetylation of the NF-κB p65 subunit, effectively silencing the transcription of pro-inflammatory cytokines. This mechanism has been validated in models of autoimmune encephalomyelitis and apical periodontitis.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch4 data-path-to-node=\"31\"\u003e\u003cb data-path-to-node=\"31\" data-index-in-node=\"0\"\u003e3. Metabolic Syndrome (Type 2 Diabetes)\u003c\/b\u003e\u003c\/h4\u003e\n\u003cp data-path-to-node=\"32\"\u003eResearch in diabetic models indicates that ARA-290 may improve metabolic homeostasis. In human subjects with T2DM, treatment was associated with improved HbA1c levels and lipid profiles, suggesting that resolving systemic inflammation is a viable strategy for metabolic correction.\u003c\/p\u003e\n\u003chr data-path-to-node=\"33\"\u003e\n\u003ch3 data-path-to-node=\"34\"\u003e\u003cb data-path-to-node=\"34\" data-index-in-node=\"0\"\u003eChemical Specifications\u003c\/b\u003e\u003c\/h3\u003e\n\u003cul data-path-to-node=\"35\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"35,0,0\"\u003e\u003cb data-path-to-node=\"35,0,0\" data-index-in-node=\"0\"\u003eMolecular Formula:\u003c\/b\u003e C51H84N16O21\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"35,1,0\"\u003e\u003cb data-path-to-node=\"35,1,0\" data-index-in-node=\"0\"\u003eMolecular Mass:\u003c\/b\u003e 1257.3 Da\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"35,2,0\"\u003e\u003cb data-path-to-node=\"35,2,0\" data-index-in-node=\"0\"\u003eStructural Modifications:\u003c\/b\u003e The N-terminal residue is modified to \u003cb data-path-to-node=\"35,2,0\" data-index-in-node=\"64\"\u003ePyroglutamic Acid (Glp)\u003c\/b\u003e. This engineering choice confers significant resistance to aminopeptidase degradation, extending the peptide's plasma stability compared to native sequences.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003chr data-path-to-node=\"37\"\u003e\n\u003ch3 data-path-to-node=\"38\"\u003e\u003cb data-path-to-node=\"38\" data-index-in-node=\"0\"\u003eStorage \u0026amp; Handling\u003c\/b\u003e\u003c\/h3\u003e\n\u003cul data-path-to-node=\"39\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"39,0,0\"\u003e\u003cb data-path-to-node=\"39,0,0\" data-index-in-node=\"0\"\u003ePhysical State:\u003c\/b\u003e Lyophilized (Freeze-Dried) White Powder.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"39,1,0\"\u003e\u003cb data-path-to-node=\"39,1,0\" data-index-in-node=\"0\"\u003eStorage (Lyophilized):\u003c\/b\u003e Store at -20°C (Freezer). Stable for up to 24 months.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"39,2,0\"\u003e\u003cb data-path-to-node=\"39,2,0\" data-index-in-node=\"0\"\u003eReconstitution:\u003c\/b\u003e\u003c\/p\u003e\n\u003cul data-path-to-node=\"39,2,1\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"39,2,1,0,0\"\u003e\u003cb data-path-to-node=\"39,2,1,0,0\" data-index-in-node=\"0\"\u003eSolvent:\u003c\/b\u003e Sterile Water or Bacteriostatic Water.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"39,2,1,1,0\"\u003e\u003cb data-path-to-node=\"39,2,1,1,0\" data-index-in-node=\"0\"\u003eVolume Note:\u003c\/b\u003e This is a high-concentration \u003cb data-path-to-node=\"39,2,1,1,0\" data-index-in-node=\"42\"\u003e14mg\u003c\/b\u003e vial. To ensure complete dissolution, use at least \u003cb data-path-to-node=\"39,2,1,1,0\" data-index-in-node=\"98\"\u003e0.5mL - 1.0mL\u003c\/b\u003e of solvent. If using PBS, a larger volume (\u0026gt;5mL) may be required due to lower solubility in buffered salts.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"39,2,1,2,0\"\u003e\u003cb data-path-to-node=\"39,2,1,2,0\" data-index-in-node=\"0\"\u003epH:\u003c\/b\u003e If dissolution is slow, a slight adjustment to pH ~8.0 facilitates solubility.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"39,3,0\"\u003e\u003cb data-path-to-node=\"39,3,0\" data-index-in-node=\"0\"\u003eStorage (Reconstituted):\u003c\/b\u003e Store at 4°C (Refrigerator). Use within 7-14 days.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003chr data-path-to-node=\"40\"\u003e\n\u003ch3 data-path-to-node=\"41\"\u003e\u003cb data-path-to-node=\"41\" data-index-in-node=\"0\"\u003eDisclaimer\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp data-path-to-node=\"42\"\u003e\u003cb data-path-to-node=\"42\" data-index-in-node=\"0\"\u003eFOR RESEARCH USE ONLY.\u003c\/b\u003e This product is a chemical compound intended strictly for laboratory research and development. It is not approved by the FDA for clinical use, diagnostics, or therapeutic procedures in humans or animals. The physiological and toxicological properties of this chemical have not been fully investigated.\u003c\/p\u003e","brand":"Peptagon","offers":[{"title":"Default Title","offer_id":47709755965654,"sku":"ARA-14","price":69.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0783\/3085\/5638\/files\/ARA-290-14mg.png?v=1768505911"},{"product_id":"bpc-157-acetate-lyophilized-research-peptide","title":"BPC-157 Acetate Research Peptide – 10mg","description":"\u003ch4 data-path-to-node=\"13\"\u003e\u003cstrong\u003eBPC-157 Acetate Peptide (Lyophilized)\u003c\/strong\u003e\u003c\/h4\u003e\n\u003cp data-path-to-node=\"14\"\u003e\u003cb data-path-to-node=\"14\" data-index-in-node=\"0\"\u003eSequence:\u003c\/b\u003e Gly-Glu-Pro-Pro-Pro-Gly-Lys-Pro-Ala-Asp-Asp-Ala-Gly-Leu-Val \u003cb data-path-to-node=\"14\" data-index-in-node=\"70\"\u003eFormat:\u003c\/b\u003e Sterile Lyophilized Powder (Vial) \u003cb data-path-to-node=\"14\" data-index-in-node=\"112\"\u003eSalt Form:\u003c\/b\u003e Acetate (Standard Research Grade) \u003cb data-path-to-node=\"14\" data-index-in-node=\"157\"\u003ePurity:\u003c\/b\u003e \u0026gt;99% (HPLC) \u003cb data-path-to-node=\"14\" data-index-in-node=\"177\"\u003eContent:\u003c\/b\u003e 10mg per vial\u003c\/p\u003e\n\u003chr data-path-to-node=\"15\"\u003e\n\u003ch3 data-path-to-node=\"16\"\u003e\u003cb data-path-to-node=\"16\" data-index-in-node=\"0\"\u003eProduct Overview\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp data-path-to-node=\"17\"\u003e\u003cb data-path-to-node=\"17\" data-index-in-node=\"0\"\u003eBPC-157 (Body Protection Compound-157)\u003c\/b\u003e is a stable pentadecapeptide derived from a partial sequence of a naturally occurring gastric protein. This \u003cb data-path-to-node=\"17\" data-index-in-node=\"147\"\u003e10mg Acetate\u003c\/b\u003e formulation is the standard reagent for parenteral (injectable) research applications.\u003c\/p\u003e\n\u003cp data-path-to-node=\"18\"\u003eKnown in the literature as a \"universal healing agent,\" BPC-157 acts as a pleiotropic modulator of the \u003cb data-path-to-node=\"18\" data-index-in-node=\"103\"\u003eNitric Oxide (NO) system\u003c\/b\u003e and the \u003cb data-path-to-node=\"18\" data-index-in-node=\"136\"\u003eVEGFR2-Akt-eNOS axis\u003c\/b\u003e. It is extensively investigated for its ability to accelerate the healing of mesenchymal tissues (tendons, ligaments, muscle) and recruit collateral blood flow in ischemic models.\u003c\/p\u003e\n\u003cp data-path-to-node=\"19\"\u003e\u003ci data-path-to-node=\"19\" data-index-in-node=\"0\"\u003eNote: This is the \u003cb data-path-to-node=\"19\" data-index-in-node=\"18\"\u003eAcetate\u003c\/b\u003e salt form, optimized for subcutaneous or intraperitoneal research. For oral stability research, the Arginate form is typically required.\u003c\/i\u003e\u003c\/p\u003e\n\u003chr data-path-to-node=\"20\"\u003e\n\u003ch3 data-path-to-node=\"21\"\u003e\u003cb data-path-to-node=\"21\" data-index-in-node=\"0\"\u003eMechanism of Action: The Homeostatic Modulator\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp data-path-to-node=\"22\"\u003eBPC-157 does not rely on a single receptor but rather modulates broad cellular signaling pathways to promote repair.\u003c\/p\u003e\n\u003ch4 data-path-to-node=\"23\"\u003e\u003cb data-path-to-node=\"23\" data-index-in-node=\"0\"\u003e1. Angiogenesis (Vascular Rescue)\u003c\/b\u003e\u003c\/h4\u003e\n\u003cp data-path-to-node=\"24\"\u003eBPC-157 activates the \u003cb data-path-to-node=\"24\" data-index-in-node=\"22\"\u003eVEGFR2-Akt-eNOS\u003c\/b\u003e pathway, driving the formation of new capillary networks.\u003c\/p\u003e\n\u003cul data-path-to-node=\"25\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"25,0,0\"\u003e\u003cb data-path-to-node=\"25,0,0\" data-index-in-node=\"0\"\u003e\"Bypassing Key\" Effect:\u003c\/b\u003e In models of ischemia, it recruits collateral vessels (like the azygos vein) to bypass obstructions and restore blood flow to damaged tissue.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"25,1,0\"\u003e\u003cb data-path-to-node=\"25,1,0\" data-index-in-node=\"0\"\u003eControlled Growth:\u003c\/b\u003e Unlike direct VEGF administration, BPC-157 promotes the formation of stable, non-leaky vasculature.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch4 data-path-to-node=\"26\"\u003e\u003cb data-path-to-node=\"26\" data-index-in-node=\"0\"\u003e2. Musculoskeletal Repair (FAK-Paxillin Axis)\u003c\/b\u003e\u003c\/h4\u003e\n\u003cp data-path-to-node=\"27\"\u003eIn tendon and muscle fibroblasts, the peptide activates \u003cb data-path-to-node=\"27\" data-index-in-node=\"56\"\u003eFocal Adhesion Kinase (FAK)\u003c\/b\u003e and \u003cb data-path-to-node=\"27\" data-index-in-node=\"88\"\u003ePaxillin\u003c\/b\u003e.\u003c\/p\u003e\n\u003cul data-path-to-node=\"28\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"28,0,0\"\u003e\u003cb data-path-to-node=\"28,0,0\" data-index-in-node=\"0\"\u003eCytoskeletal Organization:\u003c\/b\u003e Enhances the migration of fibroblasts to the site of injury.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"28,1,0\"\u003e\u003cb data-path-to-node=\"28,1,0\" data-index-in-node=\"0\"\u003eGHR Upregulation:\u003c\/b\u003e It specifically upregulates \u003cb data-path-to-node=\"28,1,0\" data-index-in-node=\"46\"\u003eGrowth Hormone Receptors (GHR)\u003c\/b\u003e in tendon tissue, increasing sensitivity to endogenous growth factors without the need for exogenous hormone administration.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch4 data-path-to-node=\"29\"\u003e\u003cb data-path-to-node=\"29\" data-index-in-node=\"0\"\u003e3. Nitric Oxide Modulation\u003c\/b\u003e\u003c\/h4\u003e\n\u003cp data-path-to-node=\"30\"\u003eBPC-157 acts as a stabilizer of the NO system. It can counteract the effects of both NO-blockade (L-NAME induced hypertension) and NO-overdose (L-Arginine induced hypotension), maintaining physiological homeostasis.\u003c\/p\u003e\n\u003chr data-path-to-node=\"31\"\u003e\n\u003ch3 data-path-to-node=\"32\"\u003e\u003cb data-path-to-node=\"32\" data-index-in-node=\"0\"\u003eKey Research Applications\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp data-path-to-node=\"33\"\u003e\u003cb data-path-to-node=\"33\" data-index-in-node=\"0\"\u003e1. Tendon \u0026amp; Ligament Healing\u003c\/b\u003e The \"Acetylated\" form is the gold standard for injection-based musculoskeletal research.\u003c\/p\u003e\n\u003cul data-path-to-node=\"34\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"34,0,0\"\u003e\u003cb data-path-to-node=\"34,0,0\" data-index-in-node=\"0\"\u003eAchilles Tendon Models:\u003c\/b\u003e Treatment significantly increases the \u003cb data-path-to-node=\"34,0,0\" data-index-in-node=\"62\"\u003e\"Load to Failure\"\u003c\/b\u003e (tensile strength) of healing tendons and restores the Young's modulus of elasticity.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"34,1,0\"\u003e\u003cb data-path-to-node=\"34,1,0\" data-index-in-node=\"0\"\u003eCorticosteroid Reversal:\u003c\/b\u003e Research indicates BPC-157 can neutralize the deleterious effects of systemic corticosteroids on tendon healing.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp data-path-to-node=\"35\"\u003e\u003cb data-path-to-node=\"35\" data-index-in-node=\"0\"\u003e2. Muscle Regeneration\u003c\/b\u003e In models of muscle crush or transection, BPC-157 mitigates atrophy and prevents scar tissue (fibrosis) formation, allowing for the complete restoration of functional motor patterns.\u003c\/p\u003e\n\u003cp data-path-to-node=\"36\"\u003e\u003cb data-path-to-node=\"36\" data-index-in-node=\"0\"\u003e3. Gastrointestinal Fistula Repair\u003c\/b\u003e Surgical research highlights the peptide's unique ability to heal complex fistulas (colovesical, rectovaginal). By promoting rapid vascularization and collagen deposition at the defect site, it achieves closure rates in animal models that far exceed standard care.\u003c\/p\u003e\n\u003cp data-path-to-node=\"37\"\u003e\u003cb data-path-to-node=\"37\" data-index-in-node=\"0\"\u003e4. Neuroprotection (Brain-Gut Axis)\u003c\/b\u003e BPC-157 demonstrates neuroprotective properties, reducing edema and neuronal death in Traumatic Brain Injury (TBI) models and antagonizing toxic encephalopathy caused by NSAID or serotonin overdose.\u003c\/p\u003e\n\u003chr data-path-to-node=\"38\"\u003e\n\u003ch3 data-path-to-node=\"39\"\u003e\u003cb data-path-to-node=\"39\" data-index-in-node=\"0\"\u003eStorage \u0026amp; Handling\u003c\/b\u003e\u003c\/h3\u003e\n\u003cul data-path-to-node=\"40\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"40,0,0\"\u003e\u003cb data-path-to-node=\"40,0,0\" data-index-in-node=\"0\"\u003ePhysical State:\u003c\/b\u003e Lyophilized (Freeze-Dried) White Powder.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"40,1,0\"\u003e\u003cb data-path-to-node=\"40,1,0\" data-index-in-node=\"0\"\u003eStorage (Lyophilized):\u003c\/b\u003e Store at -20°C (Freezer). Stable for \u0026gt;24 months.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"40,2,0\"\u003e\u003cb data-path-to-node=\"40,2,0\" data-index-in-node=\"0\"\u003eReconstitution:\u003c\/b\u003e\u003c\/p\u003e\n\u003cul data-path-to-node=\"40,2,1\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"40,2,1,0,0\"\u003e\u003cb data-path-to-node=\"40,2,1,0,0\" data-index-in-node=\"0\"\u003eSolvent:\u003c\/b\u003e Bacteriostatic Water or Sterile Saline.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"40,2,1,1,0\"\u003e\u003cb data-path-to-node=\"40,2,1,1,0\" data-index-in-node=\"0\"\u003eSolubility:\u003c\/b\u003e Freely soluble.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"40,3,0\"\u003e\u003cb data-path-to-node=\"40,3,0\" data-index-in-node=\"0\"\u003eStorage (Reconstituted):\u003c\/b\u003e Store at 4°C (Refrigerator). Use within 14 days. \u003cb data-path-to-node=\"40,3,0\" data-index-in-node=\"74\"\u003eAvoid freeze-thaw cycles.\u003c\/b\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003chr data-path-to-node=\"41\"\u003e\n\u003ch3 data-path-to-node=\"42\"\u003e\u003cb data-path-to-node=\"42\" data-index-in-node=\"0\"\u003eDisclaimer\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp data-path-to-node=\"43\"\u003e\u003cb data-path-to-node=\"43\" data-index-in-node=\"0\"\u003eFOR RESEARCH USE ONLY.\u003c\/b\u003e This product is a chemical compound intended strictly for laboratory research and development. It is not approved by the FDA for clinical use, diagnostics, or therapeutic procedures in humans or animals. The physiological and toxicological properties of this chemical have not been fully investigated.\u003c\/p\u003e","brand":"Peptagon","offers":[{"title":"Default Title","offer_id":47709778837718,"sku":"BPC157-AC-10","price":37.0,"currency_code":"USD","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0783\/3085\/5638\/files\/BPC-157-Acetate-Research-Peptide-10mg.png?v=1768835718"},{"product_id":"bpc-157-peptide-solution-research-vial","title":"BPC-157 Research Peptide Solution – 5mg \/ 10mg \/ 20mg","description":"\u003ch3 data-section-id=\"8w0o8b\" data-start=\"295\" data-end=\"357\"\u003e\u003cstrong data-start=\"299\" data-end=\"357\"\u003eHigh-Purity BPC-157 Solution for Research Applications\u003c\/strong\u003e\u003c\/h3\u003e\n\u003cp data-start=\"359\" data-end=\"548\"\u003eBPC-157 (Body Protection Compound-157) is a synthetic pentadecapeptide composed of 15 amino acids (GEPPPGKPADDAGLV), originally derived from a protein fragment found in human gastric juice.\u003c\/p\u003e\n\u003cp data-start=\"550\" data-end=\"736\"\u003eThis product is supplied as a \u003cstrong data-start=\"580\" data-end=\"613\"\u003epre-dissolved liquid solution\u003c\/strong\u003e, providing convenience and consistency for laboratory environments where precise handling and repeatability are essential.\u003c\/p\u003e\n\u003chr data-start=\"738\" data-end=\"741\"\u003e\n\u003ch3 data-section-id=\"pm8yra\" data-start=\"743\" data-end=\"763\"\u003e\u003cstrong data-start=\"747\" data-end=\"763\"\u003eKey Features\u003c\/strong\u003e\u003c\/h3\u003e\n\u003cul data-start=\"764\" data-end=\"992\"\u003e\n\u003cli data-section-id=\"521rk1\" data-start=\"764\" data-end=\"804\"\u003e\n\u003cp data-start=\"766\" data-end=\"804\"\u003e\u003cstrong data-start=\"766\" data-end=\"786\"\u003eAvailable Sizes:\u003c\/strong\u003e 5mg, 10mg, 20mg\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli data-section-id=\"173jx07\" data-start=\"805\" data-end=\"843\"\u003e\n\u003cp data-start=\"807\" data-end=\"843\"\u003e\u003cstrong data-start=\"807\" data-end=\"818\"\u003eFormat:\u003c\/strong\u003e Liquid solution (vial)\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli data-section-id=\"pffqqm\" data-start=\"844\" data-end=\"877\"\u003e\n\u003cp data-start=\"846\" data-end=\"877\"\u003e\u003cstrong data-start=\"846\" data-end=\"859\"\u003eSequence:\u003c\/strong\u003e GEPPPGKPADDAGLV\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli data-section-id=\"j2qt25\" data-start=\"878\" data-end=\"943\"\u003e\n\u003cp data-start=\"880\" data-end=\"943\"\u003e\u003cstrong data-start=\"880\" data-end=\"896\"\u003eHigh Purity:\u003c\/strong\u003e Manufactured for research-grade applications\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003chr data-start=\"994\" data-end=\"997\"\u003e\n\u003ch2 data-section-id=\"1engmd9\" data-start=\"999\" data-end=\"1024\"\u003e\u003cstrong data-start=\"1002\" data-end=\"1024\"\u003eMechanism Overview\u003c\/strong\u003e\u003c\/h2\u003e\n\u003cp data-start=\"1026\" data-end=\"1200\"\u003eBPC-157 has been investigated in preclinical research as a signaling modulator interacting with multiple biological pathways related to cellular response and tissue dynamics.\u003c\/p\u003e\n\u003chr data-start=\"1202\" data-end=\"1205\"\u003e\n\u003ch3 data-section-id=\"j6owv3\" data-start=\"1207\" data-end=\"1234\"\u003e\u003cstrong data-start=\"1211\" data-end=\"1234\"\u003eAngiogenic Pathways\u003c\/strong\u003e\u003c\/h3\u003e\n\u003cp data-start=\"1236\" data-end=\"1384\"\u003eResearch has explored BPC-157’s interaction with signaling pathways associated with vascular activity, including VEGFR2-Akt-eNOS-related mechanisms.\u003c\/p\u003e\n\u003cp data-start=\"1386\" data-end=\"1437\"\u003eThese pathways are commonly studied in relation to:\u003c\/p\u003e\n\u003cul data-start=\"1438\" data-end=\"1532\"\u003e\n\u003cli data-section-id=\"1ae56bw\" data-start=\"1438\" data-end=\"1469\"\u003e\n\u003cp data-start=\"1440\" data-end=\"1469\"\u003eCapillary network formation\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli data-section-id=\"4mwhpd\" data-start=\"1470\" data-end=\"1500\"\u003e\n\u003cp data-start=\"1472\" data-end=\"1500\"\u003eEndothelial cell signaling\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli data-section-id=\"1vexhh7\" data-start=\"1501\" data-end=\"1532\"\u003e\n\u003cp data-start=\"1503\" data-end=\"1532\"\u003eVascular response processes\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003chr data-start=\"1534\" data-end=\"1537\"\u003e\n\u003ch3 data-section-id=\"dlm7bw\" data-start=\"1539\" data-end=\"1587\"\u003e\u003cstrong data-start=\"1543\" data-end=\"1587\"\u003eCell Adhesion \u0026amp; Migration (FAK\/Paxillin)\u003c\/strong\u003e\u003c\/h3\u003e\n\u003cp data-start=\"1589\" data-end=\"1665\"\u003eIn experimental models, BPC-157 has been associated with pathways involving:\u003c\/p\u003e\n\u003cul data-start=\"1666\" data-end=\"1720\"\u003e\n\u003cli data-section-id=\"3x69uy\" data-start=\"1666\" data-end=\"1697\"\u003e\n\u003cp data-start=\"1668\" data-end=\"1697\"\u003eFocal Adhesion Kinase (FAK)\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli data-section-id=\"18v9q1d\" data-start=\"1698\" data-end=\"1720\"\u003e\n\u003cp data-start=\"1700\" data-end=\"1720\"\u003ePaxillin signaling\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp data-start=\"1722\" data-end=\"1753\"\u003eThese pathways are relevant to:\u003c\/p\u003e\n\u003cul data-start=\"1754\" data-end=\"1834\"\u003e\n\u003cli data-section-id=\"1pwfzfm\" data-start=\"1754\" data-end=\"1772\"\u003e\n\u003cp data-start=\"1756\" data-end=\"1772\"\u003eCell migration\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli data-section-id=\"1teml33\" data-start=\"1773\" data-end=\"1802\"\u003e\n\u003cp data-start=\"1775\" data-end=\"1802\"\u003eCytoskeletal organization\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli data-section-id=\"xaqj0q\" data-start=\"1803\" data-end=\"1834\"\u003e\n\u003cp data-start=\"1805\" data-end=\"1834\"\u003eCellular adhesion processes\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003chr data-start=\"1836\" data-end=\"1839\"\u003e\n\u003ch3 data-section-id=\"1nl1udp\" data-start=\"1841\" data-end=\"1880\"\u003e\u003cstrong data-start=\"1845\" data-end=\"1880\"\u003eNitric Oxide System Interaction\u003c\/strong\u003e\u003c\/h3\u003e\n\u003cp data-start=\"1882\" data-end=\"1994\"\u003eBPC-157 has also been studied for its interaction with nitric oxide (NO)-related pathways, which play a role in:\u003c\/p\u003e\n\u003cul data-start=\"1995\" data-end=\"2101\"\u003e\n\u003cli data-section-id=\"16vjo9m\" data-start=\"1995\" data-end=\"2017\"\u003e\n\u003cp data-start=\"1997\" data-end=\"2017\"\u003eCellular signaling\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli data-section-id=\"bbcxps\" data-start=\"2018\" data-end=\"2062\"\u003e\n\u003cp data-start=\"2020\" data-end=\"2062\"\u003eVascular function in experimental models\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli data-section-id=\"9wwbjq\" data-start=\"2063\" data-end=\"2101\"\u003e\n\u003cp data-start=\"2065\" data-end=\"2101\"\u003ePhysiological regulation processes\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003chr data-start=\"2103\" data-end=\"2106\"\u003e\n\u003ch2 data-section-id=\"4za2qr\" data-start=\"2108\" data-end=\"2131\"\u003e\u003cstrong data-start=\"2111\" data-end=\"2131\"\u003eResearch Context\u003c\/strong\u003e\u003c\/h2\u003e\n\u003cp data-start=\"2133\" data-end=\"2212\"\u003eBPC-157 continues to be a subject of interest in preclinical studies involving:\u003c\/p\u003e\n\u003cul data-start=\"2214\" data-end=\"2351\"\u003e\n\u003cli data-section-id=\"1l3wp6i\" data-start=\"2214\" data-end=\"2240\"\u003e\n\u003cp data-start=\"2216\" data-end=\"2240\"\u003eTissue response models\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli data-section-id=\"1rq3u23\" data-start=\"2241\" data-end=\"2272\"\u003e\n\u003cp data-start=\"2243\" data-end=\"2272\"\u003eCellular signaling pathways\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli data-section-id=\"k405p5\" data-start=\"2273\" data-end=\"2311\"\u003e\n\u003cp data-start=\"2275\" data-end=\"2311\"\u003eVascular and angiogenesis research\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli data-section-id=\"fhmey5\" data-start=\"2312\" data-end=\"2351\"\u003e\n\u003cp data-start=\"2314\" data-end=\"2351\"\u003eNitric oxide-related investigations\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003chr data-start=\"2353\" data-end=\"2356\"\u003e\n\u003ch2 data-section-id=\"1rzaed1\" data-start=\"2358\" data-end=\"2383\"\u003e\u003cstrong data-start=\"2361\" data-end=\"2383\"\u003eStorage \u0026amp; Handling\u003c\/strong\u003e\u003c\/h2\u003e\n\u003cul data-start=\"2385\" data-end=\"2568\"\u003e\n\u003cli data-section-id=\"1xcicio\" data-start=\"2385\" data-end=\"2426\"\u003e\n\u003cp data-start=\"2387\" data-end=\"2426\"\u003e\u003cstrong data-start=\"2387\" data-end=\"2402\"\u003eAppearance:\u003c\/strong\u003e Clear liquid solution\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli data-section-id=\"dt7no2\" data-start=\"2427\" data-end=\"2477\"\u003e\n\u003cp data-start=\"2429\" data-end=\"2477\"\u003e\u003cstrong data-start=\"2429\" data-end=\"2453\"\u003eRecommended Storage:\u003c\/strong\u003e 2–8°C (Refrigeration)\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli data-section-id=\"1oj2i35\" data-start=\"2478\" data-end=\"2517\"\u003e\n\u003cp data-start=\"2480\" data-end=\"2517\"\u003eAvoid contamination during handling\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli data-section-id=\"1sur3y9\" data-start=\"2518\" data-end=\"2568\"\u003e\n\u003cp data-start=\"2520\" data-end=\"2568\"\u003eDo not freeze unless specified by manufacturer\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003chr data-start=\"2570\" data-end=\"2573\"\u003e\n\u003ch2 data-section-id=\"1pt7sk9\" data-start=\"2575\" data-end=\"2598\"\u003e\u003cstrong data-start=\"2578\" data-end=\"2598\"\u003eImportant Notice\u003c\/strong\u003e\u003c\/h2\u003e\n\u003cp data-start=\"2600\" data-end=\"2625\"\u003e\u003cstrong data-start=\"2600\" data-end=\"2625\"\u003eFOR RESEARCH USE ONLY\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp data-start=\"2627\" data-end=\"2710\"\u003eThis product is intended strictly for laboratory research and development purposes.\u003c\/p\u003e\n\u003cul data-start=\"2712\" data-end=\"2854\"\u003e\n\u003cli data-section-id=\"4kaw9m\" data-start=\"2712\" data-end=\"2747\"\u003e\n\u003cp data-start=\"2714\" data-end=\"2747\"\u003eNot for human or veterinary use\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli data-section-id=\"1mfyl7l\" data-start=\"2748\" data-end=\"2798\"\u003e\n\u003cp data-start=\"2750\" data-end=\"2798\"\u003eNot for diagnostic or therapeutic applications\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli data-section-id=\"aro3jp\" data-start=\"2799\" data-end=\"2854\"\u003e\n\u003cp data-start=\"2801\" data-end=\"2854\"\u003eNot approved by the FDA or any regulatory authority\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e","brand":"Peptagon","offers":[{"title":"5mg","offer_id":47709780443350,"sku":"BPC157-5","price":30.0,"currency_code":"USD","in_stock":true},{"title":"10mg","offer_id":47709780476118,"sku":"BPC157-10","price":37.0,"currency_code":"USD","in_stock":true},{"title":"20mg","offer_id":47709780508886,"sku":"BPC157-20","price":94.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0783\/3085\/5638\/files\/BPC-157-5mg.png?v=1768507432"},{"product_id":"cartalax-ala-glu-asp-research-peptide","title":"Cartalax Research Peptide – 25mg","description":"\u003ch4 data-path-to-node=\"13\"\u003e\u003cstrong\u003eCartalax Peptide (Lyophilized)\u003c\/strong\u003e\u003c\/h4\u003e\n\u003cp data-path-to-node=\"14\"\u003e\u003cb data-path-to-node=\"14\" data-index-in-node=\"0\"\u003eSequence:\u003c\/b\u003e Ala-Glu-Asp (AED) \u003cb data-path-to-node=\"14\" data-index-in-node=\"28\"\u003eFormat:\u003c\/b\u003e Sterile Lyophilized Powder (Vial) \u003cb data-path-to-node=\"14\" data-index-in-node=\"70\"\u003eClass:\u003c\/b\u003e Synthetic Peptide Bioregulator (Cytogen AC-4) \u003cb data-path-to-node=\"14\" data-index-in-node=\"123\"\u003ePurity:\u003c\/b\u003e \u0026gt;98% (HPLC) \u003cb data-path-to-node=\"14\" data-index-in-node=\"143\"\u003eContent:\u003c\/b\u003e 25mg per vial\u003c\/p\u003e\n\u003chr data-path-to-node=\"15\"\u003e\n\u003ch3 data-path-to-node=\"16\"\u003e\u003cb data-path-to-node=\"16\" data-index-in-node=\"0\"\u003eProduct Overview\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp data-path-to-node=\"17\"\u003e\u003cb data-path-to-node=\"17\" data-index-in-node=\"0\"\u003eCartalax\u003c\/b\u003e (also designated as \u003cb data-path-to-node=\"17\" data-index-in-node=\"29\"\u003eT-31\u003c\/b\u003e or \u003cb data-path-to-node=\"17\" data-index-in-node=\"37\"\u003eAC-4\u003c\/b\u003e) is a synthetic tripeptide (L-Alanyl-L-Glutamyl-L-Aspartic acid) designed to mimic specific peptide fragments found in young, healthy cartilage. It belongs to the \"Khavinson Peptide\" family of bioregulators.\u003c\/p\u003e\n\u003cp data-path-to-node=\"18\"\u003eUnlike traditional growth factors that act on cell surface receptors, Cartalax functions as an \u003cb data-path-to-node=\"18\" data-index-in-node=\"95\"\u003eepigenetic switch\u003c\/b\u003e. It is engineered to penetrate the nuclei of chondrocytes and fibroblasts, interacting directly with chromatin to reactivate the gene expression programs associated with tissue repair. It is the primary subject of research for reversing connective tissue senescence, treating osteoarthritis, and functionalizing scaffolds for tissue engineering.\u003c\/p\u003e\n\u003cp data-path-to-node=\"19\"\u003e\u003ci data-path-to-node=\"19\" data-index-in-node=\"0\"\u003eNote: Do not confuse AC-4 (Cartalax\/Cartilage) with AC-2 (Vesugen\/Vascular).\u003c\/i\u003e\u003c\/p\u003e\n\u003chr data-path-to-node=\"20\"\u003e\n\u003ch3 data-path-to-node=\"21\"\u003e\u003cb data-path-to-node=\"21\" data-index-in-node=\"0\"\u003eMechanism of Action: Epigenetic Remodeling\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp data-path-to-node=\"22\"\u003eCartalax operates via the \"Sequence-Specific DNA Binding Model.\" Its nanoscale size allow it to pass through nuclear pores and bind to the major groove of DNA.\u003c\/p\u003e\n\u003cul data-path-to-node=\"23\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"23,0,0\"\u003e\u003cb data-path-to-node=\"23,0,0\" data-index-in-node=\"0\"\u003eChromatin Relaxation:\u003c\/b\u003e The peptide reduces the electrostatic attraction between histones and DNA. This converts silenced Heterochromatin into active Euchromatin, allowing repair genes to be transcribed.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"23,1,0\"\u003e\u003cb data-path-to-node=\"23,1,0\" data-index-in-node=\"0\"\u003eTarget Gene Activation:\u003c\/b\u003e\u003c\/p\u003e\n\u003cul data-path-to-node=\"23,1,1\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"23,1,1,0,0\"\u003e\u003cb data-path-to-node=\"23,1,1,0,0\" data-index-in-node=\"0\"\u003eCOL11A1 Upregulation:\u003c\/b\u003e It specifically acts as a \"matrikine,\" mimicking Type XI collagen breakdown to signal the synthesis of new Type XI collagen (critical for nucleating Type II fibrils).\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"23,1,1,1,0\"\u003e\u003cb data-path-to-node=\"23,1,1,1,0\" data-index-in-node=\"0\"\u003eProliferation:\u003c\/b\u003e Significantly increases \u003cb data-path-to-node=\"23,1,1,1,0\" data-index-in-node=\"39\"\u003eKi-67\u003c\/b\u003e expression, signaling senescent cells to re-enter the cell cycle.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"23,1,1,2,0\"\u003e\u003cb data-path-to-node=\"23,1,1,2,0\" data-index-in-node=\"0\"\u003eAnti-Apoptotic:\u003c\/b\u003e Downregulates \u003cb data-path-to-node=\"23,1,1,2,0\" data-index-in-node=\"30\"\u003ep53\u003c\/b\u003e and \u003cb data-path-to-node=\"23,1,1,2,0\" data-index-in-node=\"38\"\u003eCaspase-3\u003c\/b\u003e, preventing cell death in aging tissues.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003chr data-path-to-node=\"24\"\u003e\n\u003ch3 data-path-to-node=\"25\"\u003e\u003cb data-path-to-node=\"25\" data-index-in-node=\"0\"\u003eKey Research Applications\u003c\/b\u003e\u003c\/h3\u003e\n\u003ch4 data-path-to-node=\"26\"\u003e\u003cb data-path-to-node=\"26\" data-index-in-node=\"0\"\u003e1. Osteoarthritis \u0026amp; Cartilage Repair\u003c\/b\u003e\u003c\/h4\u003e\n\u003cp data-path-to-node=\"27\"\u003eIn organotypic tissue cultures (explants), Cartalax has been shown to increase the \"Area Index\" (migration and growth of cells) by \u003cb data-path-to-node=\"27\" data-index-in-node=\"131\"\u003e30-40%\u003c\/b\u003e.\u003c\/p\u003e\n\u003cul data-path-to-node=\"28\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"28,0,0\"\u003e\u003cb data-path-to-node=\"28,0,0\" data-index-in-node=\"0\"\u003eSenescence Reversal:\u003c\/b\u003e It targets the \"senescence-associated secretory phenotype\" (SASP), shifting chondrocytes from a catabolic state to an anabolic state.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"28,1,0\"\u003e\u003cb data-path-to-node=\"28,1,0\" data-index-in-node=\"0\"\u003eMatrix Architecture:\u003c\/b\u003e By promoting Type XI collagen, it ensures the proper structural organization of the cartilage matrix, distinct from generic collagen boosters.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch4 data-path-to-node=\"29\"\u003e\u003cb data-path-to-node=\"29\" data-index-in-node=\"0\"\u003e2. Osteoporosis \u0026amp; Bone Density\u003c\/b\u003e\u003c\/h4\u003e\n\u003cp data-path-to-node=\"30\"\u003eResearch in ovariectomized rat models indicates that Cartalax mitigates the loss of Bone Mineral Density (BMD). The Ala-Glu-Asp sequence appears to influence osteoblasts via mechanisms similar to those in chondrocytes, supporting mineralization.\u003c\/p\u003e\n\u003ch4 data-path-to-node=\"31\"\u003e\u003cb data-path-to-node=\"31\" data-index-in-node=\"0\"\u003e3. Tissue Engineering (Scaffolds)\u003c\/b\u003e\u003c\/h4\u003e\n\u003cp data-path-to-node=\"32\"\u003eCartalax is utilized in bio-material research to functionalize hydrogels. By chemically tethering the peptide to scaffolds (e.g., chitosan or PEG), researchers can create \"bioactive\" implants that drive stem cell differentiation toward the chondrogenic lineage.\u003c\/p\u003e\n\u003chr data-path-to-node=\"33\"\u003e\n\u003ch3 data-path-to-node=\"34\"\u003e\u003cb data-path-to-node=\"34\" data-index-in-node=\"0\"\u003eStorage \u0026amp; Handling\u003c\/b\u003e\u003c\/h3\u003e\n\u003cul data-path-to-node=\"35\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"35,0,0\"\u003e\u003cb data-path-to-node=\"35,0,0\" data-index-in-node=\"0\"\u003ePhysical State:\u003c\/b\u003e Lyophilized (Freeze-Dried) Powder.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"35,1,0\"\u003e\u003cb data-path-to-node=\"35,1,0\" data-index-in-node=\"0\"\u003eStorage (Powder):\u003c\/b\u003e Store at -20°C (Freezer). Stable for up to 24 months.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"35,2,0\"\u003e\u003cb data-path-to-node=\"35,2,0\" data-index-in-node=\"0\"\u003eReconstitution:\u003c\/b\u003e\u003c\/p\u003e\n\u003cul data-path-to-node=\"35,2,1\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"35,2,1,0,0\"\u003e\u003cb data-path-to-node=\"35,2,1,0,0\" data-index-in-node=\"0\"\u003eSolvent:\u003c\/b\u003e Bacteriostatic Water or Sterile PBS.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"35,2,1,1,0\"\u003e\u003cb data-path-to-node=\"35,2,1,1,0\" data-index-in-node=\"0\"\u003eSolubility:\u003c\/b\u003e Highly soluble due to acidic residues.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"35,3,0\"\u003e\u003cb data-path-to-node=\"35,3,0\" data-index-in-node=\"0\"\u003eStorage (Liquid):\u003c\/b\u003e Store at 4°C (Refrigerator). Use within 14 days or aliquot and freeze to avoid degradation.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003chr data-path-to-node=\"36\"\u003e\n\u003ch3 data-path-to-node=\"37\"\u003e\u003cb data-path-to-node=\"37\" data-index-in-node=\"0\"\u003eDisclaimer\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp data-path-to-node=\"38\"\u003e\u003cb data-path-to-node=\"38\" data-index-in-node=\"0\"\u003eFOR RESEARCH USE ONLY.\u003c\/b\u003e This product is a chemical compound intended strictly for laboratory research and development. It is not approved by the FDA for clinical use, diagnostics, or therapeutic procedures in humans or animals. The physiological and toxicological properties of this chemical have not been fully investigated.\u003c\/p\u003e","brand":"Peptagon","offers":[{"title":"Default Title","offer_id":47709952147670,"sku":"CARTA-25","price":41.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0783\/3085\/5638\/files\/Cartalax-25mg.png?v=1768507488"},{"product_id":"kpv-alpha-msh-11-13-research-peptide","title":"KPV Research Peptide – 10mg","description":"\u003ch4 data-path-to-node=\"13\"\u003e\u003cstrong\u003eKPV Peptide (Lyophilized)\u003c\/strong\u003e\u003c\/h4\u003e\n\u003cp data-path-to-node=\"14\"\u003e\u003cb data-path-to-node=\"14\" data-index-in-node=\"0\"\u003eSequence:\u003c\/b\u003e Lys-Pro-Val (Alpha-MSH residues 11-13) \u003cb data-path-to-node=\"14\" data-index-in-node=\"49\"\u003eFormat:\u003c\/b\u003e Sterile Lyophilized Powder (Vial) \u003cb data-path-to-node=\"14\" data-index-in-node=\"91\"\u003eMechanism:\u003c\/b\u003e Nuclear NF-κB Translocation Inhibitor \u003cb data-path-to-node=\"14\" data-index-in-node=\"140\"\u003ePurity:\u003c\/b\u003e \u0026gt;98% (HPLC) \u003cb data-path-to-node=\"14\" data-index-in-node=\"160\"\u003eContent:\u003c\/b\u003e 10mg per vial\u003c\/p\u003e\n\u003chr data-path-to-node=\"15\"\u003e\n\u003ch3 data-path-to-node=\"16\"\u003e\u003cb data-path-to-node=\"16\" data-index-in-node=\"0\"\u003eProduct Overview\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp data-path-to-node=\"17\"\u003e\u003cb data-path-to-node=\"17\" data-index-in-node=\"0\"\u003eKPV\u003c\/b\u003e is a naturally occurring tripeptide derived from the C-terminus of Alpha-Melanocyte Stimulating Hormone (α-MSH). It retains the potent anti-inflammatory and antimicrobial properties of the parent hormone but lacks the pigmentary effects (skin darkening) associated with full-length α-MSH.\u003c\/p\u003e\n\u003cp data-path-to-node=\"18\"\u003eUnlike traditional anti-inflammatories that suppress the entire immune system, KPV acts as a targeted modulator. It utilizes the \u003cb data-path-to-node=\"18\" data-index-in-node=\"129\"\u003ePepT1 transporter\u003c\/b\u003e, which is upregulated in inflamed tissues, to enter cells and block inflammatory signaling at the nuclear level. This \"seek-and-destroy\" mechanism makes it a primary candidate for researching inflammatory bowel disease (IBD), dermatitis, and wound healing.\u003c\/p\u003e\n\u003chr data-path-to-node=\"19\"\u003e\n\u003ch3 data-path-to-node=\"20\"\u003e\u003cb data-path-to-node=\"20\" data-index-in-node=\"0\"\u003eMechanism of Action: The Nuclear Shield\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp data-path-to-node=\"21\"\u003eKPV functions primarily by inhibiting the \u003cb data-path-to-node=\"21\" data-index-in-node=\"42\"\u003eNF-κB\u003c\/b\u003e pathway, the master regulator of inflammation.\u003c\/p\u003e\n\u003cul data-path-to-node=\"22\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"22,0,0\"\u003e\u003cb data-path-to-node=\"22,0,0\" data-index-in-node=\"0\"\u003eNuclear Import Blockade:\u003c\/b\u003e KPV enters the cell and binds to \u003cb data-path-to-node=\"22,0,0\" data-index-in-node=\"58\"\u003eImportin-alpha3\u003c\/b\u003e. This physically blocks the transport of NF-κB into the nucleus, preventing the transcription of pro-inflammatory cytokines like TNF-alpha and IL-6.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"22,1,0\"\u003e\u003cb data-path-to-node=\"22,1,0\" data-index-in-node=\"0\"\u003eTargeted Delivery:\u003c\/b\u003e It is actively transported into inflamed cells via the PepT1 transporter, accumulating precisely where inflammation is highest while sparing healthy tissue.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"22,2,0\"\u003e\u003cb data-path-to-node=\"22,2,0\" data-index-in-node=\"0\"\u003eAntimicrobial Activity:\u003c\/b\u003e KPV is cationic and disrupts the membranes of pathogens. Research shows it kills 95-97% of \u003ci data-path-to-node=\"22,2,0\" data-index-in-node=\"115\"\u003eS. aureus\u003c\/i\u003e (including MRSA) and \u003ci data-path-to-node=\"22,2,0\" data-index-in-node=\"146\"\u003eC. albicans\u003c\/i\u003e within hours.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003chr data-path-to-node=\"23\"\u003e\n\u003ch3 data-path-to-node=\"24\"\u003e\u003cb data-path-to-node=\"24\" data-index-in-node=\"0\"\u003eKey Research Applications\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp data-path-to-node=\"25\"\u003e\u003cb data-path-to-node=\"25\" data-index-in-node=\"0\"\u003e1. Inflammatory Bowel Disease (IBD)\u003c\/b\u003e In murine colitis models, oral KPV administration significantly reduced weight loss, colonic inflammation (MPO activity), and pro-inflammatory cytokine levels. Its efficacy is enhanced by hydrogel delivery systems that target the inflamed colon.\u003c\/p\u003e\n\u003cp data-path-to-node=\"26\"\u003e\u003cb data-path-to-node=\"26\" data-index-in-node=\"0\"\u003e2. Dermatology \u0026amp; Wound Healing\u003c\/b\u003e KPV accelerates wound closure and reduces scarring.\u003c\/p\u003e\n\u003cul data-path-to-node=\"27\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"27,0,0\"\u003e\u003cb data-path-to-node=\"27,0,0\" data-index-in-node=\"0\"\u003eRe-epithelialization:\u003c\/b\u003e Promotes rapid keratinocyte migration, closing wounds faster.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"27,1,0\"\u003e\u003cb data-path-to-node=\"27,1,0\" data-index-in-node=\"0\"\u003eAnti-Fibrotic:\u003c\/b\u003e Reduces inflammation early in the healing process, preventing the excessive collagen deposition that leads to scars.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"27,2,0\"\u003e\u003cb data-path-to-node=\"27,2,0\" data-index-in-node=\"0\"\u003ePsoriasis\/Dermatitis:\u003c\/b\u003e Investigated for its ability to calm skin inflammation without the side effects of topical steroids.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp data-path-to-node=\"28\"\u003e\u003cb data-path-to-node=\"28\" data-index-in-node=\"0\"\u003e3. Antimicrobial Defense\u003c\/b\u003e Unlike antibiotics, KPV has a dual mechanism: it kills bacteria\/fungi directly via membrane disruption \u003ci data-path-to-node=\"28\" data-index-in-node=\"128\"\u003eand\u003c\/i\u003e suppresses the host inflammation caused by the infection. It is effective against biofilms and resistant strains like MRSA.\u003c\/p\u003e\n\u003chr data-path-to-node=\"29\"\u003e\n\u003ch3 data-path-to-node=\"30\"\u003e\u003cb data-path-to-node=\"30\" data-index-in-node=\"0\"\u003eStorage \u0026amp; Handling\u003c\/b\u003e\u003c\/h3\u003e\n\u003cul data-path-to-node=\"31\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"31,0,0\"\u003e\u003cb data-path-to-node=\"31,0,0\" data-index-in-node=\"0\"\u003ePhysical State:\u003c\/b\u003e Lyophilized (Freeze-Dried) White Powder.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"31,1,0\"\u003e\u003cb data-path-to-node=\"31,1,0\" data-index-in-node=\"0\"\u003eStorage (Powder):\u003c\/b\u003e Store at -20°C (Freezer). Stable for up to 36 months.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"31,2,0\"\u003e\u003cb data-path-to-node=\"31,2,0\" data-index-in-node=\"0\"\u003eReconstitution:\u003c\/b\u003e\u003c\/p\u003e\n\u003cul data-path-to-node=\"31,2,1\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"31,2,1,0,0\"\u003e\u003cb data-path-to-node=\"31,2,1,0,0\" data-index-in-node=\"0\"\u003eSolvent:\u003c\/b\u003e Sterile Water or Saline.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"31,2,1,1,0\"\u003e\u003cb data-path-to-node=\"31,2,1,1,0\" data-index-in-node=\"0\"\u003eSolubility:\u003c\/b\u003e Highly soluble due to hydrophilic residues.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"31,3,0\"\u003e\u003cb data-path-to-node=\"31,3,0\" data-index-in-node=\"0\"\u003eStorage (Liquid):\u003c\/b\u003e Store at 4°C (Refrigerator). Use within 14-21 days.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003chr data-path-to-node=\"32\"\u003e\n\u003ch3 data-path-to-node=\"33\"\u003e\u003cb data-path-to-node=\"33\" data-index-in-node=\"0\"\u003eDisclaimer\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp data-path-to-node=\"34\"\u003e\u003cb data-path-to-node=\"34\" data-index-in-node=\"0\"\u003eFOR RESEARCH USE ONLY.\u003c\/b\u003e This product is a chemical compound intended strictly for laboratory research and development. It is not approved by the FDA for clinical use, diagnostics, or therapeutic procedures in humans or animals. The physiological and toxicological properties of this chemical have not been fully investigated.\u003c\/p\u003e","brand":"Peptagon","offers":[{"title":"Default Title","offer_id":47712310952150,"sku":"KPV-10","price":31.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0783\/3085\/5638\/files\/KPV-10mg.png?v=1768507503"},{"product_id":"ll-37-human-cathelicidin-research-peptide","title":"LL-37 Research Peptide – 5mg \/ 10mg","description":"\u003ch2 data-path-to-node=\"13\"\u003e\u003cstrong\u003eLL-37 Peptide (Lyophilized)\u003c\/strong\u003e\u003c\/h2\u003e\n\u003ch2 data-section-id=\"1qhk4i3\" data-start=\"940\" data-end=\"959\"\u003eSpecifications\u003c\/h2\u003e\n\u003cp data-start=\"960\" data-end=\"1168\"\u003e\u003cstrong data-start=\"960\" data-end=\"973\"\u003eSequence:\u003c\/strong\u003e LLGDFFRKSK EKIGKEFKRI VQRIKDFLRN LVPRTES\u003cbr data-start=\"1014\" data-end=\"1017\"\u003e\u003cstrong data-start=\"1017\" data-end=\"1028\"\u003eFormat:\u003c\/strong\u003e Sterile Lyophilized Powder (Vial)\u003cbr data-start=\"1062\" data-end=\"1065\"\u003e\u003cstrong data-start=\"1065\" data-end=\"1077\"\u003eContent:\u003c\/strong\u003e 10mg per vial\u003cbr data-start=\"1091\" data-end=\"1094\"\u003e\u003cstrong data-start=\"1094\" data-end=\"1104\"\u003eClass:\u003c\/strong\u003e Host Defense Peptide (Cathelicidin)\u003cbr data-start=\"1140\" data-end=\"1143\"\u003e\u003cstrong data-start=\"1143\" data-end=\"1154\"\u003ePurity:\u003c\/strong\u003e ≥98% (HPLC)\u003c\/p\u003e\n\u003cp data-start=\"1170\" data-end=\"1259\"\u003e\u003cstrong data-start=\"1170\" data-end=\"1187\"\u003eIntended Use:\u003c\/strong\u003e For laboratory research purposes only. Not for human or veterinary use.\u003c\/p\u003e\n\u003chr data-start=\"1261\" data-end=\"1264\"\u003e\n\u003ch2 data-section-id=\"53drpp\" data-start=\"1266\" data-end=\"1287\"\u003eProduct Overview\u003c\/h2\u003e\n\u003cp data-start=\"1289\" data-end=\"1592\"\u003eLL-37 is the only cathelicidin-derived peptide identified in humans and plays a central role in innate immune system signaling. It is classified as a host defense peptide and is widely studied for its interaction with microbial membranes, immune signaling pathways, and cellular communication processes.\u003c\/p\u003e\n\u003cp data-start=\"1594\" data-end=\"1903\"\u003eLL-37 functions as a multifunctional signaling peptide, participating in antimicrobial defense, immune cell recruitment, and modulation of inflammatory pathways. Unlike traditional small-molecule antibiotics, LL-37 operates through biophysical membrane interactions and receptor-mediated signaling mechanisms.\u003c\/p\u003e\n\u003cp data-start=\"1905\" data-end=\"2092\"\u003eIn research settings, LL-37 is utilized to investigate antimicrobial peptide behavior, host-pathogen interactions, and signaling pathways associated with inflammation and tissue response.\u003c\/p\u003e\n\u003chr data-start=\"2094\" data-end=\"2097\"\u003e\n\u003ch2 data-section-id=\"10snmn7\" data-start=\"2099\" data-end=\"2121\"\u003eWhy This Peptide?\u003c\/h2\u003e\n\u003cp data-start=\"2123\" data-end=\"2287\"\u003eLL-37 is one of the most extensively studied human antimicrobial peptides due to its dual role in both direct microbial interaction and immune signaling modulation.\u003c\/p\u003e\n\u003cp data-start=\"2289\" data-end=\"2317\"\u003eKey characteristics include:\u003c\/p\u003e\n\u003cul data-start=\"2319\" data-end=\"2605\"\u003e\n\u003cli data-section-id=\"1t6ipz0\" data-start=\"2319\" data-end=\"2384\"\u003eAmphipathic α-helical structure enabling membrane interaction\u003c\/li\u003e\n\u003cli data-section-id=\"cn3lwm\" data-start=\"2385\" data-end=\"2446\"\u003eBroad interaction with microbial membranes and endotoxins\u003c\/li\u003e\n\u003cli data-section-id=\"grioyr\" data-start=\"2447\" data-end=\"2518\"\u003eInvolvement in immune signaling and cellular communication pathways\u003c\/li\u003e\n\u003cli data-section-id=\"171p6jh\" data-start=\"2519\" data-end=\"2605\"\u003eActivity across multiple research models (microbial, immune, and tissue signaling)\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp data-start=\"2607\" data-end=\"2690\"\u003eThese features make LL-37 a foundational compound in host defense peptide research.\u003c\/p\u003e\n\u003chr data-start=\"2692\" data-end=\"2695\"\u003e\n\u003ch2 data-section-id=\"178yx1o\" data-start=\"2697\" data-end=\"2766\"\u003eMechanism of Action: Membrane Interaction \u0026amp; Signaling Modulation\u003c\/h2\u003e\n\u003cp data-start=\"2768\" data-end=\"2859\"\u003eLL-37 exhibits a multimodal mechanism depending on environmental context and concentration.\u003c\/p\u003e\n\u003ch3 data-section-id=\"vshl77\" data-start=\"2861\" data-end=\"2911\"\u003eMembrane Interaction (Antimicrobial Context)\u003c\/h3\u003e\n\u003cp data-start=\"2912\" data-end=\"3103\"\u003eLL-37 forms an amphipathic α-helix that interacts with negatively charged microbial membranes. This interaction can lead to membrane destabilization and pore formation in experimental models.\u003c\/p\u003e\n\u003ch3 data-section-id=\"iz6jw6\" data-start=\"3105\" data-end=\"3130\"\u003eBiofilm Interaction\u003c\/h3\u003e\n\u003cp data-start=\"3131\" data-end=\"3317\"\u003eLL-37 has been studied in models examining bacterial quorum sensing systems and biofilm formation dynamics, including effects on signaling pathways associated with microbial aggregation.\u003c\/p\u003e\n\u003ch3 data-section-id=\"xq70dp\" data-start=\"3319\" data-end=\"3348\"\u003eEndotoxin (LPS) Binding\u003c\/h3\u003e\n\u003cp data-start=\"3349\" data-end=\"3509\"\u003eLL-37 binds lipopolysaccharide (LPS), allowing investigation into pathways related to Toll-like receptor (TLR4) signaling and downstream inflammatory responses.\u003c\/p\u003e\n\u003ch3 data-section-id=\"hydtql\" data-start=\"3511\" data-end=\"3544\"\u003eImmune Signaling Modulation\u003c\/h3\u003e\n\u003cp data-start=\"3545\" data-end=\"3625\"\u003eLL-37 interacts with multiple receptors involved in immune signaling, including:\u003c\/p\u003e\n\u003cul data-start=\"3627\" data-end=\"3713\"\u003e\n\u003cli data-section-id=\"69c971\" data-start=\"3627\" data-end=\"3661\"\u003eFPR2 (formyl peptide receptor)\u003c\/li\u003e\n\u003cli data-section-id=\"1s7xh4d\" data-start=\"3662\" data-end=\"3679\"\u003eP2X7 receptor\u003c\/li\u003e\n\u003cli data-section-id=\"o5ut7l\" data-start=\"3680\" data-end=\"3713\"\u003eEGFR transactivation pathways\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp data-start=\"3715\" data-end=\"3829\"\u003eThese interactions are studied in relation to immune cell recruitment, signaling cascades, and pathway modulation.\u003c\/p\u003e\n\u003chr data-start=\"3831\" data-end=\"3834\"\u003e\n\u003ch2 data-section-id=\"1k1p0ls\" data-start=\"3836\" data-end=\"3867\"\u003ePreclinical Research Areas\u003c\/h2\u003e\n\u003cp data-start=\"3869\" data-end=\"4054\"\u003e\u003cstrong data-start=\"3869\" data-end=\"3906\"\u003e1. Antimicrobial Peptide Research\u003c\/strong\u003e\u003cbr data-start=\"3906\" data-end=\"3909\"\u003eStudied in models involving Gram-positive, Gram-negative, and fungal organisms, focusing on membrane interaction and microbial response pathways.\u003c\/p\u003e\n\u003cp data-start=\"4056\" data-end=\"4183\"\u003e\u003cstrong data-start=\"4056\" data-end=\"4099\"\u003e2. Biofilm \u0026amp; Microbial Signaling Models\u003c\/strong\u003e\u003cbr data-start=\"4099\" data-end=\"4102\"\u003eUsed in research examining quorum sensing systems and biofilm formation dynamics.\u003c\/p\u003e\n\u003cp data-start=\"4185\" data-end=\"4348\"\u003e\u003cstrong data-start=\"4185\" data-end=\"4232\"\u003e3. Immune Signaling \u0026amp; Inflammation Research\u003c\/strong\u003e\u003cbr data-start=\"4232\" data-end=\"4235\"\u003eInvestigated for its role in immune cell signaling, cytokine pathway modulation, and receptor-level interactions.\u003c\/p\u003e\n\u003cp data-start=\"4350\" data-end=\"4516\"\u003e\u003cstrong data-start=\"4350\" data-end=\"4391\"\u003e4. Tissue \u0026amp; Cellular Signaling Models\u003c\/strong\u003e\u003cbr data-start=\"4391\" data-end=\"4394\"\u003eStudied in keratinocyte and endothelial cell models to evaluate signaling pathways associated with cellular communication.\u003c\/p\u003e\n\u003cp data-start=\"4518\" data-end=\"4709\"\u003e\u003cstrong data-start=\"4518\" data-end=\"4566\"\u003e5. Oncology Signaling Context (Experimental)\u003c\/strong\u003e\u003cbr data-start=\"4566\" data-end=\"4569\"\u003eLL-37 has been evaluated in models examining signaling pathways in different tissue environments, with context-dependent effects observed.\u003c\/p\u003e\n\u003chr data-start=\"4711\" data-end=\"4714\"\u003e\n\u003ch2 data-section-id=\"ce0tqk\" data-start=\"4716\" data-end=\"4733\"\u003eApplications\u003c\/h2\u003e\n\u003cul data-start=\"4735\" data-end=\"4944\"\u003e\n\u003cli data-section-id=\"blzgyi\" data-start=\"4735\" data-end=\"4776\"\u003eAntimicrobial peptide research models\u003c\/li\u003e\n\u003cli data-section-id=\"1y19lfu\" data-start=\"4777\" data-end=\"4815\"\u003eBiofilm and quorum sensing studies\u003c\/li\u003e\n\u003cli data-section-id=\"1k4sqk1\" data-start=\"4816\" data-end=\"4853\"\u003eImmune signaling pathway analysis\u003c\/li\u003e\n\u003cli data-section-id=\"1aozsy0\" data-start=\"4854\" data-end=\"4905\"\u003eCell culture (keratinocyte, immune cell models)\u003c\/li\u003e\n\u003cli data-section-id=\"1e0nmmg\" data-start=\"4906\" data-end=\"4944\"\u003eHost-pathogen interaction research\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003chr data-start=\"4946\" data-end=\"4949\"\u003e\n\u003ch2 data-section-id=\"1jtb6ys\" data-start=\"4951\" data-end=\"4975\"\u003eResearch Advantages\u003c\/h2\u003e\n\u003cul data-start=\"4977\" data-end=\"5270\"\u003e\n\u003cli data-section-id=\"4zq4gk\" data-start=\"4977\" data-end=\"5015\"\u003eHuman-derived host defense peptide\u003c\/li\u003e\n\u003cli data-section-id=\"5pj6xb\" data-start=\"5016\" data-end=\"5079\"\u003eAmphipathic structure enabling membrane interaction studies\u003c\/li\u003e\n\u003cli data-section-id=\"958lu5\" data-start=\"5080\" data-end=\"5147\"\u003eBroad applicability across microbial and immune research models\u003c\/li\u003e\n\u003cli data-section-id=\"1dil6zk\" data-start=\"5148\" data-end=\"5205\"\u003eMulti-pathway signaling relevance (immune + cellular)\u003c\/li\u003e\n\u003cli data-section-id=\"1ocm8cy\" data-start=\"5206\" data-end=\"5270\"\u003eWell-characterized peptide with extensive literature support\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003chr data-start=\"5272\" data-end=\"5275\"\u003e\n\u003ch2 data-section-id=\"1qk69px\" data-start=\"5277\" data-end=\"5300\"\u003eStorage \u0026amp; Handling\u003c\/h2\u003e\n\u003cp data-start=\"5302\" data-end=\"5357\"\u003e\u003cstrong data-start=\"5302\" data-end=\"5321\"\u003ePhysical State:\u003c\/strong\u003e Lyophilized (freeze-dried) powder\u003c\/p\u003e\n\u003cp data-start=\"5359\" data-end=\"5426\"\u003e\u003cstrong data-start=\"5359\" data-end=\"5380\"\u003eStorage (Powder):\u003c\/strong\u003e Store at -20°C. Stable for extended storage\u003c\/p\u003e\n\u003cp data-start=\"5428\" data-end=\"5449\"\u003e\u003cstrong data-start=\"5428\" data-end=\"5447\"\u003eReconstitution:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cul data-start=\"5450\" data-end=\"5586\"\u003e\n\u003cli data-section-id=\"99vxfy\" data-start=\"5450\" data-end=\"5471\"\u003eUse sterile water\u003c\/li\u003e\n\u003cli data-section-id=\"twzdsl\" data-start=\"5472\" data-end=\"5532\"\u003eAvoid high-salt buffers initially to prevent aggregation\u003c\/li\u003e\n\u003cli data-section-id=\"19zbkhw\" data-start=\"5533\" data-end=\"5586\"\u003eUse low-binding labware (LL-37 adheres to surfaces)\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp data-start=\"5588\" data-end=\"5661\"\u003e\u003cstrong data-start=\"5588\" data-end=\"5609\"\u003eStorage (Liquid):\u003c\/strong\u003e\u003cbr data-start=\"5609\" data-end=\"5612\"\u003eStore at 4°C and use within a limited timeframe\u003c\/p\u003e\n\u003chr data-start=\"5663\" data-end=\"5666\"\u003e\n\u003ch2 data-section-id=\"9rcx7q\" data-start=\"5668\" data-end=\"5683\"\u003eDisclaimer\u003c\/h2\u003e\n\u003cp data-start=\"5685\" data-end=\"6009\"\u003eFOR RESEARCH USE ONLY. This product is a chemical compound intended strictly for laboratory research and development. It is not approved by the FDA for clinical use, diagnostics, or therapeutic procedures in humans or animals. The physiological and toxicological properties of this chemical have not been fully investigated.\u003c\/p\u003e","brand":"Peptagon","offers":[{"title":"5mg","offer_id":48170384949462,"sku":"LL37-NC-5","price":33.0,"currency_code":"USD","in_stock":false},{"title":"10mg","offer_id":48170384982230,"sku":"LL37-NC-10","price":63.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0783\/3085\/5638\/files\/LL-37-5mg.png?v=1768507525"},{"product_id":"ll-37-complex-human-cathelicidin-research-peptide","title":"LL-37 Complex Research Peptide – 5mg","description":"\u003ch4 data-path-to-node=\"13\"\u003e\u003cstrong\u003eLL-37 Complex Peptide (Lyophilized)\u003c\/strong\u003e\u003c\/h4\u003e\n\u003cp data-path-to-node=\"14\"\u003e\u003cb data-path-to-node=\"14\" data-index-in-node=\"0\"\u003eSequence:\u003c\/b\u003e LLGDFFRKSK EKIGKEFKRI VQRIKDFLRN LVPRTES \u003cb data-path-to-node=\"14\" data-index-in-node=\"51\"\u003eFormat:\u003c\/b\u003e Sterile Lyophilized Powder (Vial) \u003cb data-path-to-node=\"14\" data-index-in-node=\"93\"\u003eStructure:\u003c\/b\u003e Amphipathic Alpha-Helix \u003cb data-path-to-node=\"14\" data-index-in-node=\"128\"\u003ePurity:\u003c\/b\u003e \u0026gt;95% (HPLC) \u003cb data-path-to-node=\"14\" data-index-in-node=\"148\"\u003eContent:\u003c\/b\u003e 5mg per vial\u003c\/p\u003e\n\u003chr data-path-to-node=\"15\"\u003e\n\u003ch3 data-path-to-node=\"16\"\u003e\u003cb data-path-to-node=\"16\" data-index-in-node=\"0\"\u003eProduct Overview\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp data-path-to-node=\"17\"\u003e\u003cb data-path-to-node=\"17\" data-index-in-node=\"0\"\u003eLL-37 Complex\u003c\/b\u003e refers to the research-grade formulation of the human cathelicidin peptide, designed to investigate its interactions with nucleic acids and host membranes.\u003c\/p\u003e\n\u003cp data-path-to-node=\"18\"\u003eWhile native LL-37 is a potent antimicrobial, this specific formulation is often utilized to study the peptide's \"alarmin\" function—its ability to form complexes with self-DNA\/RNA. These complexes are critical triggers in autoimmune pathways (like psoriasis and lupus) and are potent stimulators of angiogenesis and wound healing via EGFR transactivation.\u003c\/p\u003e\n\u003chr data-path-to-node=\"19\"\u003e\n\u003ch3 data-path-to-node=\"20\"\u003e\u003cb data-path-to-node=\"20\" data-index-in-node=\"0\"\u003eMechanism of Action: The Nucleic Acid Carrier\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp data-path-to-node=\"21\"\u003eLL-37 acts as a molecular bridge between the innate immune system and host tissues.\u003c\/p\u003e\n\u003cul data-path-to-node=\"22\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"22,0,0\"\u003e\u003cb data-path-to-node=\"22,0,0\" data-index-in-node=\"0\"\u003eNucleic Acid Complexation:\u003c\/b\u003e The cationic peptide binds to anionic DNA and RNA released from damaged cells. It protects these nucleic acids from degradation and transports them into immune cells (pDCs), where they activate \u003cb data-path-to-node=\"22,0,0\" data-index-in-node=\"221\"\u003eTLR9\u003c\/b\u003e and \u003cb data-path-to-node=\"22,0,0\" data-index-in-node=\"230\"\u003eTLR7\u003c\/b\u003e, triggering interferon responses.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"22,1,0\"\u003e\u003cb data-path-to-node=\"22,1,0\" data-index-in-node=\"0\"\u003eEGFR Transactivation:\u003c\/b\u003e In epithelial tissues, LL-37 activates metalloproteinases (ADAMs) which cleave and release HB-EGF. This transactivates the \u003cb data-path-to-node=\"22,1,0\" data-index-in-node=\"145\"\u003eEpidermal Growth Factor Receptor (EGFR)\u003c\/b\u003e, driving keratinocyte migration and re-epithelialization.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"22,2,0\"\u003e\u003cb data-path-to-node=\"22,2,0\" data-index-in-node=\"0\"\u003eAngiogenesis:\u003c\/b\u003e Stimulates the proliferation of endothelial cells and the formation of new blood vessels via the FPR2 receptor and VEGF upregulation.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003chr data-path-to-node=\"23\"\u003e\n\u003ch3 data-path-to-node=\"24\"\u003e\u003cb data-path-to-node=\"24\" data-index-in-node=\"0\"\u003eKey Research Applications\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp data-path-to-node=\"25\"\u003e\u003cb data-path-to-node=\"25\" data-index-in-node=\"0\"\u003e1. Autoimmunity (Psoriasis\/Lupus)\u003c\/b\u003e The \"LL-37 Complex\" is the central autoantigen in psoriasis research. It converts inert self-DNA into a potent inflammatory signal, driving the Th17\/IFN-alpha axis.\u003c\/p\u003e\n\u003cp data-path-to-node=\"26\"\u003e\u003cb data-path-to-node=\"26\" data-index-in-node=\"0\"\u003e2. Chronic Wound Healing\u003c\/b\u003e Investigated for its ability to convert chronic, non-healing wounds into active repair sites by stimulating angiogenesis and neutralizing bacterial biofilms.\u003c\/p\u003e\n\u003cp data-path-to-node=\"27\"\u003e\u003cb data-path-to-node=\"27\" data-index-in-node=\"0\"\u003e3. Biofilm Disruption\u003c\/b\u003e Unlike antibiotics, LL-37 disrupts the physical integrity of bacterial biofilms (e.g., \u003ci data-path-to-node=\"27\" data-index-in-node=\"109\"\u003eP. aeruginosa\u003c\/i\u003e) at sub-lethal concentrations by downregulating quorum sensing systems.\u003c\/p\u003e\n\u003chr data-path-to-node=\"28\"\u003e\n\u003ch3 data-path-to-node=\"29\"\u003e\u003cb data-path-to-node=\"29\" data-index-in-node=\"0\"\u003eStorage \u0026amp; Handling\u003c\/b\u003e\u003c\/h3\u003e\n\u003cul data-path-to-node=\"30\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"30,0,0\"\u003e\u003cb data-path-to-node=\"30,0,0\" data-index-in-node=\"0\"\u003ePhysical State:\u003c\/b\u003e Lyophilized (Freeze-Dried) White Powder.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"30,1,0\"\u003e\u003cb data-path-to-node=\"30,1,0\" data-index-in-node=\"0\"\u003eStorage (Powder):\u003c\/b\u003e Store at -20°C (Freezer). Stable for up to 24 months.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"30,2,0\"\u003e\u003cb data-path-to-node=\"30,2,0\" data-index-in-node=\"0\"\u003eReconstitution:\u003c\/b\u003e\u003c\/p\u003e\n\u003cul data-path-to-node=\"30,2,1\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"30,2,1,0,0\"\u003e\u003cb data-path-to-node=\"30,2,1,0,0\" data-index-in-node=\"0\"\u003eSolvent:\u003c\/b\u003e Sterile Water (Endotoxin-Free). \u003cb data-path-to-node=\"30,2,1,0,0\" data-index-in-node=\"41\"\u003eAvoid high-salt buffers\u003c\/b\u003e initially to prevent aggregation.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"30,2,1,1,0\"\u003e\u003cb data-path-to-node=\"30,2,1,1,0\" data-index-in-node=\"0\"\u003eConcentration:\u003c\/b\u003e Reconstitute to \u0026gt;100 µg\/mL to minimize adsorption loss.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"30,3,0\"\u003e\u003cb data-path-to-node=\"30,3,0\" data-index-in-node=\"0\"\u003eStorage (Liquid):\u003c\/b\u003e Store at 4°C (Refrigerator). Use within 7 days.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003chr data-path-to-node=\"31\"\u003e\n\u003ch3 data-path-to-node=\"32\"\u003e\u003cb data-path-to-node=\"32\" data-index-in-node=\"0\"\u003eDisclaimer\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp data-path-to-node=\"33\"\u003e\u003cb data-path-to-node=\"33\" data-index-in-node=\"0\"\u003eFOR RESEARCH USE ONLY.\u003c\/b\u003e This product is a chemical compound intended strictly for laboratory research and development. It is not approved by the FDA for clinical use, diagnostics, or therapeutic procedures in humans or animals. The physiological and toxicological properties of this chemical have not been fully investigated.\u003c\/p\u003e","brand":"Peptagon","offers":[{"title":"Default Title","offer_id":47712362070230,"sku":"LL37-5","price":52.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0783\/3085\/5638\/files\/LL-37-Complex-5mg_2fc0c889-f93c-4f7c-8d3b-841ebe413934.png?v=1768507565"},{"product_id":"mots-c-mitochondrial-derived-research-peptide","title":"MOTS-c Research Peptide – 10mg","description":"\u003ch4 data-path-to-node=\"13\"\u003e\u003cstrong\u003eMOTS-c Peptide (Lyophilized)\u003c\/strong\u003e\u003c\/h4\u003e\n\u003cp data-path-to-node=\"14\"\u003e\u003cb data-path-to-node=\"14\" data-index-in-node=\"0\"\u003eSequence:\u003c\/b\u003e Met-Arg-Trp-Gln-Glu-Met-Gly-Tyr-Ile-Phe-Tyr-Pro-Arg-Lys-Leu-Arg \u003cb data-path-to-node=\"14\" data-index-in-node=\"74\"\u003eFormat:\u003c\/b\u003e Sterile Lyophilized Powder (Vial) \u003cb data-path-to-node=\"14\" data-index-in-node=\"116\"\u003eOrigin:\u003c\/b\u003e Mitochondrial-Derived Peptide (12S rRNA) \u003cb data-path-to-node=\"14\" data-index-in-node=\"165\"\u003ePurity:\u003c\/b\u003e \u0026gt;98% (HPLC) \u003cb data-path-to-node=\"14\" data-index-in-node=\"185\"\u003eContent:\u003c\/b\u003e 10mg per vial\u003c\/p\u003e\n\u003chr data-path-to-node=\"15\"\u003e\n\u003ch3 data-path-to-node=\"16\"\u003e\u003cb data-path-to-node=\"16\" data-index-in-node=\"0\"\u003eProduct Overview\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp data-path-to-node=\"17\"\u003e\u003cb data-path-to-node=\"17\" data-index-in-node=\"0\"\u003eMOTS-c\u003c\/b\u003e (Mitochondrial Open Reading Frame of the 12S rRNA-c) is a 16-amino acid peptide encoded within the mitochondrial genome. It represents a breakthrough in understanding how mitochondria communicate with the rest of the cell.\u003c\/p\u003e\n\u003cp data-path-to-node=\"18\"\u003eUnlike traditional hormones, MOTS-c acts as a \u003cb data-path-to-node=\"18\" data-index-in-node=\"46\"\u003emitochondrial signal\u003c\/b\u003e, translocating to the nucleus to regulate gene expression in response to metabolic stress. It is extensively researched for its ability to mimic the physiological effects of exercise, regulate insulin sensitivity, and promote healthy aging via the AMPK pathway.\u003c\/p\u003e\n\u003chr data-path-to-node=\"19\"\u003e\n\u003ch3 data-path-to-node=\"20\"\u003e\u003cb data-path-to-node=\"20\" data-index-in-node=\"0\"\u003eMechanism of Action: The Mitonuclear Signal\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp data-path-to-node=\"21\"\u003eMOTS-c functions via a unique dual mechanism involving metabolic enzyme inhibition and nuclear gene regulation.\u003c\/p\u003e\n\u003cul data-path-to-node=\"22\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"22,0,0\"\u003e\u003cb data-path-to-node=\"22,0,0\" data-index-in-node=\"0\"\u003eFolate-AMPK Axis:\u003c\/b\u003e It inhibits the enzyme ATIC in the folate cycle, leading to an accumulation of AICAR. This activates \u003cb data-path-to-node=\"22,0,0\" data-index-in-node=\"119\"\u003eAMPK\u003c\/b\u003e, the cell's master metabolic switch, driving fatty acid oxidation and glucose uptake without the need for insulin.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"22,1,0\"\u003e\u003cb data-path-to-node=\"22,1,0\" data-index-in-node=\"0\"\u003eNuclear Translocation:\u003c\/b\u003e Under stress, MOTS-c moves into the nucleus where it binds to \u003cb data-path-to-node=\"22,1,0\" data-index-in-node=\"85\"\u003eNRF2\u003c\/b\u003e and Antioxidant Response Elements (ARE), upregulating cytoprotective genes to defend against oxidative stress.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"22,2,0\"\u003e\u003cb data-path-to-node=\"22,2,0\" data-index-in-node=\"0\"\u003eMyostatin Inhibition:\u003c\/b\u003e Downregulates myostatin expression via the AKT-FOXO1 axis, preventing muscle atrophy.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003chr data-path-to-node=\"23\"\u003e\n\u003ch3 data-path-to-node=\"24\"\u003e\u003cb data-path-to-node=\"24\" data-index-in-node=\"0\"\u003eKey Research Applications\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp data-path-to-node=\"25\"\u003e\u003cb data-path-to-node=\"25\" data-index-in-node=\"0\"\u003e1. Metabolic Regulation (Obesity \u0026amp; Diabetes)\u003c\/b\u003e MOTS-c is a potent insulin sensitizer. In high-fat diet models, it prevents diet-induced obesity and reverses insulin resistance by promoting GLUT4 translocation and \"browning\" of white adipose tissue (thermogenesis).\u003c\/p\u003e\n\u003cp data-path-to-node=\"26\"\u003e\u003cb data-path-to-node=\"26\" data-index-in-node=\"0\"\u003e2. Exercise Mimicry \u0026amp; Performance\u003c\/b\u003e Known as an \"exercise mimetic,\" MOTS-c administration significantly improves physical performance. In aged mice, treatment \u003cb data-path-to-node=\"26\" data-index-in-node=\"157\"\u003edoubled running capacity\u003c\/b\u003e and improved grip strength, effectively rejuvenating skeletal muscle function.\u003c\/p\u003e\n\u003cp data-path-to-node=\"27\"\u003e\u003cb data-path-to-node=\"27\" data-index-in-node=\"0\"\u003e3. Gerontology (Anti-Aging)\u003c\/b\u003e Research (Reynolds et al.) indicates that late-life administration of MOTS-c can extend healthspan and lifespan. It restores the communication between mitochondria and the nucleus, which typically degrades with age, reducing frailty and metabolic decline.\u003c\/p\u003e\n\u003cp data-path-to-node=\"28\"\u003e\u003cb data-path-to-node=\"28\" data-index-in-node=\"0\"\u003e4. Osteobiology\u003c\/b\u003e Promotes bone formation (osteoblastogenesis) via the TGF-beta\/Smad pathway while inhibiting bone breakdown (osteoclasts), offering a potential avenue for osteoporosis research.\u003c\/p\u003e\n\u003chr data-path-to-node=\"29\"\u003e\n\u003ch3 data-path-to-node=\"30\"\u003e\u003cb data-path-to-node=\"30\" data-index-in-node=\"0\"\u003eStorage \u0026amp; Handling\u003c\/b\u003e\u003c\/h3\u003e\n\u003cul data-path-to-node=\"31\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"31,0,0\"\u003e\u003cb data-path-to-node=\"31,0,0\" data-index-in-node=\"0\"\u003ePhysical State:\u003c\/b\u003e Lyophilized (Freeze-Dried) White Powder.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"31,1,0\"\u003e\u003cb data-path-to-node=\"31,1,0\" data-index-in-node=\"0\"\u003eStorage (Powder):\u003c\/b\u003e Store at -20°C (Freezer). Stable for up to 24 months.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"31,2,0\"\u003e\u003cb data-path-to-node=\"31,2,0\" data-index-in-node=\"0\"\u003eReconstitution:\u003c\/b\u003e\u003c\/p\u003e\n\u003cul data-path-to-node=\"31,2,1\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"31,2,1,0,0\"\u003e\u003cb data-path-to-node=\"31,2,1,0,0\" data-index-in-node=\"0\"\u003eSolvent:\u003c\/b\u003e Sterile Water or Bacteriostatic Water.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"31,2,1,1,0\"\u003e\u003cb data-path-to-node=\"31,2,1,1,0\" data-index-in-node=\"0\"\u003eSolubility:\u003c\/b\u003e Soluble in water.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"31,3,0\"\u003e\u003cb data-path-to-node=\"31,3,0\" data-index-in-node=\"0\"\u003eStorage (Liquid):\u003c\/b\u003e Store at 4°C (Refrigerator). Use within 14 days. \u003cb data-path-to-node=\"31,3,0\" data-index-in-node=\"67\"\u003eDo not freeze-thaw repeatedly.\u003c\/b\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003chr data-path-to-node=\"32\"\u003e\n\u003ch3 data-path-to-node=\"33\"\u003e\u003cb data-path-to-node=\"33\" data-index-in-node=\"0\"\u003eDisclaimer\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp data-path-to-node=\"34\"\u003e\u003cb data-path-to-node=\"34\" data-index-in-node=\"0\"\u003eFOR RESEARCH USE ONLY.\u003c\/b\u003e This product is a chemical compound intended strictly for laboratory research and development. It is not approved by the FDA for clinical use, diagnostics, or therapeutic procedures in humans or animals. The physiological and toxicological properties of this chemical have not been fully investigated.\u003c\/p\u003e","brand":"Peptagon","offers":[{"title":"Default Title","offer_id":47712368034006,"sku":"MOTSC-10","price":36.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0783\/3085\/5638\/files\/MOTs-C-10mg.png?v=1768507596"},{"product_id":"nad-nicotinamide-adenine-dinucleotide-1000mg-research-vial","title":"NAD+ Research Vial – 1000mg – 5mL","description":"\u003ch4 data-path-to-node=\"13\"\u003e\u003cstrong\u003eNAD+ (Nicotinamide Adenine Dinucleotide) 1000mg\u003c\/strong\u003e\u003c\/h4\u003e\n\u003cp data-path-to-node=\"14\"\u003e\u003cb data-path-to-node=\"14\" data-index-in-node=\"0\"\u003eConcentration:\u003c\/b\u003e 200 mg\/mL (1000mg total in 5mL) \u003cb data-path-to-node=\"14\" data-index-in-node=\"47\"\u003eFormat:\u003c\/b\u003e Sterile Aqueous Solution (High-Load) \u003cb data-path-to-node=\"14\" data-index-in-node=\"92\"\u003eOrigin:\u003c\/b\u003e Biofermented (Yeast-Derived, Endotoxin-Free) \u003cb data-path-to-node=\"14\" data-index-in-node=\"145\"\u003ePurity:\u003c\/b\u003e \u0026gt;99% (Pharmaceutical Grade) \u003cb data-path-to-node=\"14\" data-index-in-node=\"181\"\u003epH:\u003c\/b\u003e Neutral-Buffered (Optimized for Stability)\u003cbr\u003e\u003c\/p\u003e\n\u003ch3 data-path-to-node=\"17\"\u003e\u003cb data-path-to-node=\"17\" data-index-in-node=\"0\"\u003eProduct Overview\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp data-path-to-node=\"18\"\u003e\u003cb data-path-to-node=\"18\" data-index-in-node=\"0\"\u003eNAD+ (Nicotinamide Adenine Dinucleotide)\u003c\/b\u003e is the central coenzyme of metabolism, essential for converting nutrients into energy (ATP). This \u003cb data-path-to-node=\"18\" data-index-in-node=\"139\"\u003e1000mg Biofermented Formulation\u003c\/b\u003e represents the pinnacle of solubility engineering, achieving a concentration of \u003cb data-path-to-node=\"18\" data-index-in-node=\"251\"\u003e200 mg\/mL\u003c\/b\u003e.\u003c\/p\u003e\n\u003cp data-path-to-node=\"19\"\u003eProduced via metabolic engineering of \u003ci data-path-to-node=\"19\" data-index-in-node=\"38\"\u003eSaccharomyces cerevisiae\u003c\/i\u003e, this formulation ensures stereochemical purity (active β-anomer only) and is rigorously purified to remove endotoxins (\u0026lt;0.35 EU\/mg). It is designed for high-dose research applications where \"flooding\" the metabolic salvage pathway is required to overcome rate-limiting enzymes.\u003c\/p\u003e\n\u003chr data-path-to-node=\"20\"\u003e\n\u003ch3 data-path-to-node=\"21\"\u003e\u003cb data-path-to-node=\"21\" data-index-in-node=\"0\"\u003eMechanism of Action: The Metabolic Master Switch\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp data-path-to-node=\"22\"\u003eNAD+ operates as both a metabolic cofactor and a signaling molecule.\u003c\/p\u003e\n\u003cul data-path-to-node=\"23\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"23,0,0\"\u003e\u003cb data-path-to-node=\"23,0,0\" data-index-in-node=\"0\"\u003eSirtuin Activation:\u003c\/b\u003e It is the obligatory substrate for Sirtuins (SIRT1-7), the \"longevity genes.\" High-dose NAD+ activates SIRT1, leading to the deacetylation of FOXO3a (stress resistance) and PGC-1alpha (mitochondrial biogenesis).\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"23,1,0\"\u003e\u003cb data-path-to-node=\"23,1,0\" data-index-in-node=\"0\"\u003eMitochondrial Rescue:\u003c\/b\u003e Reverses \"pseudohypoxia\" (the false signal of low oxygen) in aging cells, restoring mitochondrial ATP production and electron transport chain efficiency.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"23,2,0\"\u003e\u003cb data-path-to-node=\"23,2,0\" data-index-in-node=\"0\"\u003eNeuroprotection (SARM1):\u003c\/b\u003e Inhibits the enzyme SARM1. In injured axons, high levels of NAD+ prevent SARM1 activation, halting axon degeneration and preserving neural architecture.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003chr data-path-to-node=\"24\"\u003e\n\u003ch3 data-path-to-node=\"25\"\u003e\u003cb data-path-to-node=\"25\" data-index-in-node=\"0\"\u003eKey Research Applications\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp data-path-to-node=\"26\"\u003e\u003cb data-path-to-node=\"26\" data-index-in-node=\"0\"\u003e1. Addiction \u0026amp; Neurotransmitter Restoration\u003c\/b\u003e High-dose NAD+ is the cornerstone of \"Brain Restoration\" research. It replenishes mitochondrial energy in neurons and re-regulates the circadian clock (via SIRT1\/CLOCK), normalizing \u003cb data-path-to-node=\"26\" data-index-in-node=\"226\"\u003edopamine synthesis\u003c\/b\u003e in the nucleus accumbens to reduce cravings and withdrawal anxiety.\u003c\/p\u003e\n\u003cp data-path-to-node=\"27\"\u003e\u003cb data-path-to-node=\"27\" data-index-in-node=\"0\"\u003e2. Anti-Aging \u0026amp; Metabolic Health\u003c\/b\u003e Investigated for its ability to mimic caloric restriction. By activating AMPK and SIRT1, it corrects dyslipidemia, improves insulin sensitivity, and promotes healthy DNA repair via PARP enzymes.\u003c\/p\u003e\n\u003cp data-path-to-node=\"28\"\u003e\u003cb data-path-to-node=\"28\" data-index-in-node=\"0\"\u003e3. Ischemia \u0026amp; Cytoprotection\u003c\/b\u003e In models of heart attack (ischemia-reperfusion), NAD+ administration reduced infarct size by up to \u003cb data-path-to-node=\"28\" data-index-in-node=\"129\"\u003e85%\u003c\/b\u003e. It salvages tissue viability by maintaining ATP levels during critical stress.\u003c\/p\u003e\n\u003chr data-path-to-node=\"29\"\u003e\n\u003ch3 data-path-to-node=\"30\"\u003e\u003cb data-path-to-node=\"30\" data-index-in-node=\"0\"\u003eStorage \u0026amp; Handling\u003c\/b\u003e\u003c\/h3\u003e\n\u003cul data-path-to-node=\"31\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"31,0,0\"\u003e\u003cb data-path-to-node=\"31,0,0\" data-index-in-node=\"0\"\u003ePhysical State:\u003c\/b\u003e Clear to slightly yellow liquid.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"31,1,0\"\u003e\u003cb data-path-to-node=\"31,1,0\" data-index-in-node=\"0\"\u003eStorage:\u003c\/b\u003e \u003cb data-path-to-node=\"31,1,0\" data-index-in-node=\"9\"\u003eMUST BE REFRIGERATED (2-8°C).\u003c\/b\u003e Do not freeze.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"31,2,0\"\u003e\u003cb data-path-to-node=\"31,2,0\" data-index-in-node=\"0\"\u003eStability:\u003c\/b\u003e This high-concentration formulation is thermodynamically stable at cold temperatures. Room temperature storage will accelerate degradation into Nicotinamide (an inhibitor).\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003chr data-path-to-node=\"32\"\u003e\n\u003ch3 data-path-to-node=\"33\"\u003e\u003cb data-path-to-node=\"33\" data-index-in-node=\"0\"\u003eDisclaimer\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp data-path-to-node=\"34\"\u003e\u003cb data-path-to-node=\"34\" data-index-in-node=\"0\"\u003eFOR RESEARCH USE ONLY.\u003c\/b\u003e This product is a chemical compound intended strictly for laboratory research and development. It is not approved by the FDA for clinical use, diagnostics, or therapeutic procedures in humans or animals. The physiological and toxicological properties of this chemical have not been fully investigated.\u003c\/p\u003e","brand":"Peptagon","offers":[{"title":"Default Title","offer_id":47712407060694,"sku":"NAD-BF-1000","price":72.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0783\/3085\/5638\/files\/NAD.png?v=1776955277"},{"product_id":"peg-mgf-pegylated-mechano-growth-factor-research-peptide","title":"PEG MGF Research Peptide – 5mg","description":"\u003ch4 data-path-to-node=\"13\"\u003e\u003cstrong\u003ePEG MGF Peptide (Lyophilized)\u003c\/strong\u003e\u003c\/h4\u003e\n\u003cp data-path-to-node=\"14\"\u003e\u003cb data-path-to-node=\"14\" data-index-in-node=\"0\"\u003eSequence:\u003c\/b\u003e PEG-Suc-Tyr-Gln-Pro-Pro-Ser-Thr-Asn-Lys-Asn-Thr-Lys-Ser-Gln-Arg-Arg-Lys-Gly-Ser-Thr-Phe-Glu-Glu-Arg-Lys \u003cb data-path-to-node=\"14\" data-index-in-node=\"114\"\u003eFormat:\u003c\/b\u003e Sterile Lyophilized Powder (Vial) \u003cb data-path-to-node=\"14\" data-index-in-node=\"156\"\u003eModification:\u003c\/b\u003e Pegylation (Polyethylene Glycol Attachment) \u003cb data-path-to-node=\"14\" data-index-in-node=\"214\"\u003ePurity:\u003c\/b\u003e \u0026gt;98% (HPLC) \u003cb data-path-to-node=\"14\" data-index-in-node=\"234\"\u003eContent:\u003c\/b\u003e 5mg per vial\u003c\/p\u003e\n\u003chr data-path-to-node=\"15\"\u003e\n\u003ch3 data-path-to-node=\"16\"\u003e\u003cb data-path-to-node=\"16\" data-index-in-node=\"0\"\u003eProduct Overview\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp data-path-to-node=\"17\"\u003e\u003cb data-path-to-node=\"17\" data-index-in-node=\"0\"\u003ePEG MGF (Pegylated Mechano Growth Factor)\u003c\/b\u003e is a chemically stabilized form of the autocrine growth factor MGF. While native MGF has a half-life of just minutes, the attachment of a Polyethylene Glycol (PEG) polymer protects the peptide from enzymatic degradation, extending its biological activity to \u003cb data-path-to-node=\"17\" data-index-in-node=\"300\"\u003e48-72 hours\u003c\/b\u003e.\u003c\/p\u003e\n\u003cp data-path-to-node=\"18\"\u003eThis modification allows for systemic administration, enabling the peptide to reach distant tissues (muscle, heart, nervous system) to activate stem cells and promote tissue repair, overcoming the limitation of native MGF which acts only locally.\u003c\/p\u003e\n\u003chr data-path-to-node=\"19\"\u003e\n\u003ch3 data-path-to-node=\"20\"\u003e\u003cb data-path-to-node=\"20\" data-index-in-node=\"0\"\u003eMechanism of Action: The Sustained Activator\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp data-path-to-node=\"21\"\u003ePEG MGF functions by activating the \"Phase 1\" repair response in tissues.\u003c\/p\u003e\n\u003cul data-path-to-node=\"22\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"22,0,0\"\u003e\u003cb data-path-to-node=\"22,0,0\" data-index-in-node=\"0\"\u003eStem Cell Proliferation:\u003c\/b\u003e Activates the \u003cb data-path-to-node=\"22,0,0\" data-index-in-node=\"39\"\u003eMAPK\/ERK pathway\u003c\/b\u003e in satellite cells (muscle stem cells), driving them to multiply. This expands the population of cells available for repair before differentiation occurs.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"22,1,0\"\u003e\u003cb data-path-to-node=\"22,1,0\" data-index-in-node=\"0\"\u003ePharmacokinetic Stability:\u003c\/b\u003e The PEG shield increases the hydrodynamic volume of the molecule, preventing renal filtration and proteolysis. This transforms a fleeting local signal into a sustained systemic therapeutic.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"22,2,0\"\u003e\u003cb data-path-to-node=\"22,2,0\" data-index-in-node=\"0\"\u003eNeuroprotection:\u003c\/b\u003e Protects neurons from ischemia and degeneration by inhibiting apoptotic pathways, independent of the IGF-1 receptor.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003chr data-path-to-node=\"23\"\u003e\n\u003ch3 data-path-to-node=\"24\"\u003e\u003cb data-path-to-node=\"24\" data-index-in-node=\"0\"\u003eKey Research Applications\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp data-path-to-node=\"25\"\u003e\u003cb data-path-to-node=\"25\" data-index-in-node=\"0\"\u003e1. Systemic Muscle Recovery\u003c\/b\u003e Ideal for research into generalized muscle wasting or recovery. Because it circulates for days, a single subcutaneous injection can target multiple muscle groups, promoting the replenishment of the stem cell pool post-exercise or injury.\u003c\/p\u003e\n\u003cp data-path-to-node=\"26\"\u003e\u003cb data-path-to-node=\"26\" data-index-in-node=\"0\"\u003e2. Cardioprotection\u003c\/b\u003e In models of heart attack (myocardial infarction), PEG MGF reduces infarct size by preventing cardiomyocyte death and recruiting cardiac progenitor cells to the site of injury.\u003c\/p\u003e\n\u003cp data-path-to-node=\"27\"\u003e\u003cb data-path-to-node=\"27\" data-index-in-node=\"0\"\u003e3. Neurodegeneration \u0026amp; Stroke\u003c\/b\u003e Investigated for its ability to protect motor neurons in ALS models and rescue hippocampal neurons following stroke. The PEGylation allows for sustained neurotrophic support.\u003c\/p\u003e\n\u003chr data-path-to-node=\"28\"\u003e\n\u003ch3 data-path-to-node=\"29\"\u003e\u003cb data-path-to-node=\"29\" data-index-in-node=\"0\"\u003eStorage \u0026amp; Handling\u003c\/b\u003e\u003c\/h3\u003e\n\u003cul data-path-to-node=\"30\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"30,0,0\"\u003e\u003cb data-path-to-node=\"30,0,0\" data-index-in-node=\"0\"\u003ePhysical State:\u003c\/b\u003e Lyophilized (Freeze-Dried) White Powder.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"30,1,0\"\u003e\u003cb data-path-to-node=\"30,1,0\" data-index-in-node=\"0\"\u003eStorage (Powder):\u003c\/b\u003e Store at -20°C (Freezer). Stable for up to 12 months.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"30,2,0\"\u003e\u003cb data-path-to-node=\"30,2,0\" data-index-in-node=\"0\"\u003eReconstitution:\u003c\/b\u003e\u003c\/p\u003e\n\u003cul data-path-to-node=\"30,2,1\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"30,2,1,0,0\"\u003e\u003cb data-path-to-node=\"30,2,1,0,0\" data-index-in-node=\"0\"\u003eSolvent:\u003c\/b\u003e Bacteriostatic Water.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"30,2,1,1,0\"\u003e\u003cb data-path-to-node=\"30,2,1,1,0\" data-index-in-node=\"0\"\u003eSolubility:\u003c\/b\u003e Highly soluble.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"30,3,0\"\u003e\u003cb data-path-to-node=\"30,3,0\" data-index-in-node=\"0\"\u003eStorage (Liquid):\u003c\/b\u003e Store at 4°C (Refrigerator). \u003cb data-path-to-node=\"30,3,0\" data-index-in-node=\"47\"\u003eUse within 4 weeks.\u003c\/b\u003e PEGylation significantly improves stability in solution compared to native peptides.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003chr data-path-to-node=\"31\"\u003e\n\u003ch3 data-path-to-node=\"32\"\u003e\u003cb data-path-to-node=\"32\" data-index-in-node=\"0\"\u003eDisclaimer\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp data-path-to-node=\"33\"\u003e\u003cb data-path-to-node=\"33\" data-index-in-node=\"0\"\u003eFOR RESEARCH USE ONLY.\u003c\/b\u003e This product is a chemical compound intended strictly for laboratory research and development. It is not approved by the FDA for clinical use, diagnostics, or therapeutic procedures in humans or animals. The physiological and toxicological properties of this chemical have not been fully investigated.\u003c\/p\u003e","brand":"Peptagon","offers":[{"title":"Default Title","offer_id":47712435011798,"sku":"PEGMGF-5","price":67.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0783\/3085\/5638\/files\/PEG-MGF-5mg.png?v=1768507685"},{"product_id":"selank-tuftsin-analog-research-peptide","title":"Selank Research Peptide – 5mg \/ 10mg","description":"\u003ch4 data-path-to-node=\"13\"\u003e\u003cstrong\u003eSelank Peptide (Lyophilized)\u003c\/strong\u003e\u003c\/h4\u003e\n\u003cp data-path-to-node=\"14\"\u003e\u003cb data-path-to-node=\"14\" data-index-in-node=\"0\"\u003eSequence:\u003c\/b\u003e Thr-Lys-Pro-Arg-Pro-Gly-Pro (TKPRPGP) \u003cb data-path-to-node=\"14\" data-index-in-node=\"48\"\u003eFormat:\u003c\/b\u003e Sterile Lyophilized Powder (Vial) \u003cb data-path-to-node=\"14\" data-index-in-node=\"90\"\u003eClass:\u003c\/b\u003e Nootropic \/ Anxiolytic \/ Immunomodulator \u003cb data-path-to-node=\"14\" data-index-in-node=\"138\"\u003ePurity:\u003c\/b\u003e \u0026gt;98% (HPLC) \u003cb data-path-to-node=\"14\" data-index-in-node=\"158\"\u003eContent:\u003c\/b\u003e 10mg per vial\u003c\/p\u003e\n\u003chr data-path-to-node=\"15\"\u003e\n\u003ch3 data-path-to-node=\"16\"\u003e\u003cb data-path-to-node=\"16\" data-index-in-node=\"0\"\u003eProduct Overview\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp data-path-to-node=\"17\"\u003e\u003cb data-path-to-node=\"17\" data-index-in-node=\"0\"\u003eSelank\u003c\/b\u003e is a synthetic heptapeptide derivative of the endogenous immunomodulator Tuftsin. It was originally developed at the Institute of Molecular Genetics (Russian Academy of Sciences) to combine anxiolytic (anti-anxiety) properties with nootropic (cognitive enhancing) effects.\u003c\/p\u003e\n\u003cp data-path-to-node=\"18\"\u003eSelank is unique in that it modulates the central nervous system without the sedation, addiction, or withdrawal symptoms associated with traditional benzodiazepines. It also retains the immune-boosting properties of its parent molecule, making it a dual-action \"neuro-immunomodulator.\"\u003c\/p\u003e\n\u003chr data-path-to-node=\"19\"\u003e\n\u003ch3 data-path-to-node=\"20\"\u003e\u003cb data-path-to-node=\"20\" data-index-in-node=\"0\"\u003eMechanism of Action: The Neuro-Regulator\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp data-path-to-node=\"21\"\u003eSelank acts as a homeostatic regulator of the nervous system.\u003c\/p\u003e\n\u003cul data-path-to-node=\"22\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"22,0,0\"\u003e\u003cb data-path-to-node=\"22,0,0\" data-index-in-node=\"0\"\u003eGABA Modulation:\u003c\/b\u003e It acts as a positive allosteric modulator of GABA-A receptors, enhancing the natural inhibitory tone of the brain to reduce anxiety and stress without sedation.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"22,1,0\"\u003e\u003cb data-path-to-node=\"22,1,0\" data-index-in-node=\"0\"\u003eEnkephalinase Inhibition:\u003c\/b\u003e Inhibits the enzymes that break down enkephalins (natural opioids), increasing their levels to stabilize mood and reduce pain perception.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"22,2,0\"\u003e\u003cb data-path-to-node=\"22,2,0\" data-index-in-node=\"0\"\u003eBDNF Upregulation:\u003c\/b\u003e Rapidly increases Brain-Derived Neurotrophic Factor (BDNF) in the hippocampus, promoting neuronal survival, synaptic plasticity, and memory consolidation.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"22,3,0\"\u003e\u003cb data-path-to-node=\"22,3,0\" data-index-in-node=\"0\"\u003eTranscriptomic Regulation:\u003c\/b\u003e Modulates the expression of inflammation-related genes (NF-κB, IL-6), protecting the brain from neuroinflammation.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003chr data-path-to-node=\"23\"\u003e\n\u003ch3 data-path-to-node=\"24\"\u003e\u003cb data-path-to-node=\"24\" data-index-in-node=\"0\"\u003eKey Research Applications\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp data-path-to-node=\"25\"\u003e\u003cb data-path-to-node=\"25\" data-index-in-node=\"0\"\u003e1. Anxiety \u0026amp; Stress Disorders\u003c\/b\u003e Selank is the benchmark for researching non-sedating anxiolytics. Clinical studies show it reduces symptoms of Generalized Anxiety Disorder (GAD) and neurasthenia, with 40% of subjects showing rapid improvement within 1-3 days.\u003c\/p\u003e\n\u003cp data-path-to-node=\"26\"\u003e\u003cb data-path-to-node=\"26\" data-index-in-node=\"0\"\u003e2. Cognitive Enhancement (Nootropic)\u003c\/b\u003e Investigated for its ability to improve memory stability, focus, and learning capacity. It aids in the consolidation of memory traces, making it a valuable tool for researching cognitive decline and ADHD.\u003c\/p\u003e\n\u003cp data-path-to-node=\"27\"\u003e\u003cb data-path-to-node=\"27\" data-index-in-node=\"0\"\u003e3. Neuroprotection \u0026amp; Immunology\u003c\/b\u003e Due to its Tuftsin lineage, Selank modulates the immune response (IL-6 suppression) and protects neurons from oxidative stress and excitotoxicity, relevant for research into viral infections and neurodegenerative diseases.\u003c\/p\u003e\n\u003chr data-path-to-node=\"28\"\u003e\n\u003ch3 data-path-to-node=\"29\"\u003e\u003cb data-path-to-node=\"29\" data-index-in-node=\"0\"\u003eStorage \u0026amp; Handling\u003c\/b\u003e\u003c\/h3\u003e\n\u003cul data-path-to-node=\"30\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"30,0,0\"\u003e\u003cb data-path-to-node=\"30,0,0\" data-index-in-node=\"0\"\u003ePhysical State:\u003c\/b\u003e Lyophilized (Freeze-Dried) White Powder.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"30,1,0\"\u003e\u003cb data-path-to-node=\"30,1,0\" data-index-in-node=\"0\"\u003eStorage (Powder):\u003c\/b\u003e Store at -20°C (Freezer). Stable for up to 36 months.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"30,2,0\"\u003e\u003cb data-path-to-node=\"30,2,0\" data-index-in-node=\"0\"\u003eReconstitution:\u003c\/b\u003e\u003c\/p\u003e\n\u003cul data-path-to-node=\"30,2,1\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"30,2,1,0,0\"\u003e\u003cb data-path-to-node=\"30,2,1,0,0\" data-index-in-node=\"0\"\u003eSolvent:\u003c\/b\u003e Sterile Water or Bacteriostatic Water.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"30,2,1,1,0\"\u003e\u003cb data-path-to-node=\"30,2,1,1,0\" data-index-in-node=\"0\"\u003eSolubility:\u003c\/b\u003e Highly soluble.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"30,3,0\"\u003e\u003cb data-path-to-node=\"30,3,0\" data-index-in-node=\"0\"\u003eStorage (Liquid):\u003c\/b\u003e Store at 4°C (Refrigerator). \u003cb data-path-to-node=\"30,3,0\" data-index-in-node=\"47\"\u003eUse within 14-21 days.\u003c\/b\u003e Selank is sensitive to heat; keep refrigerated at all times after mixing.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003chr data-path-to-node=\"31\"\u003e\n\u003ch3 data-path-to-node=\"32\"\u003e\u003cb data-path-to-node=\"32\" data-index-in-node=\"0\"\u003eDisclaimer\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp data-path-to-node=\"33\"\u003e\u003cb data-path-to-node=\"33\" data-index-in-node=\"0\"\u003eFOR RESEARCH USE ONLY.\u003c\/b\u003e This product is a chemical compound intended strictly for laboratory research and development. It is not approved by the FDA for clinical use, diagnostics, or therapeutic procedures in humans or animals. The physiological and toxicological properties of this chemical have not been fully investigated.\u003c\/p\u003e","brand":"Peptagon","offers":[{"title":"5mg","offer_id":47712538820822,"sku":"SELANK-5","price":29.0,"currency_code":"USD","in_stock":true},{"title":"10mg","offer_id":47712538853590,"sku":"SELANK-10","price":37.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0783\/3085\/5638\/files\/Selank-5mg.png?v=1768507725"},{"product_id":"semax-acth-4-10-analog-research-peptide","title":"Semax Research Peptide – 30mg","description":"\u003ch4 data-path-to-node=\"13\"\u003e\u003cstrong\u003eSemax Peptide (Lyophilized)\u003c\/strong\u003e\u003c\/h4\u003e\n\u003cp data-path-to-node=\"14\"\u003e\u003cb data-path-to-node=\"14\" data-index-in-node=\"0\"\u003eSequence:\u003c\/b\u003e Met-Glu-His-Phe-Pro-Gly-Pro (MEHFPGP) \u003cb data-path-to-node=\"14\" data-index-in-node=\"48\"\u003eFormat:\u003c\/b\u003e Sterile Lyophilized Powder (Vial) \u003cb data-path-to-node=\"14\" data-index-in-node=\"90\"\u003eClass:\u003c\/b\u003e Nootropic \/ Neuroprotective Peptide \u003cb data-path-to-node=\"14\" data-index-in-node=\"133\"\u003ePurity:\u003c\/b\u003e \u0026gt;98% (HPLC) \u003cb data-path-to-node=\"14\" data-index-in-node=\"153\"\u003eContent:\u003c\/b\u003e 30mg per vial\u003c\/p\u003e\n\u003chr data-path-to-node=\"15\"\u003e\n\u003ch3 data-path-to-node=\"16\"\u003e\u003cb data-path-to-node=\"16\" data-index-in-node=\"0\"\u003eProduct Overview\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp data-path-to-node=\"17\"\u003e\u003cb data-path-to-node=\"17\" data-index-in-node=\"0\"\u003eSemax\u003c\/b\u003e is a synthetic heptapeptide derived from the ACTH(4-10) fragment. It was engineered at the Institute of Molecular Genetics (Russian Academy of Sciences) to retain the potent neurotropic effects of ACTH—such as improved learning and memory—without any hormonal or steroidogenic activity.\u003c\/p\u003e\n\u003cp data-path-to-node=\"18\"\u003eThis \u003cb data-path-to-node=\"18\" data-index-in-node=\"5\"\u003e30mg High-Concentration Formulation\u003c\/b\u003e is designed for advanced research protocols, specifically those investigating acute neuroprotection (e.g., post-stroke or TBI models) where higher cumulative doses are required to modulate the brain's transcriptome and suppress inflammatory gene clusters.\u003c\/p\u003e\n\u003chr data-path-to-node=\"19\"\u003e\n\u003ch3 data-path-to-node=\"20\"\u003e\u003cb data-path-to-node=\"20\" data-index-in-node=\"0\"\u003eMechanism of Action: The Genomic Modulator\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp data-path-to-node=\"21\"\u003eSemax operates via rapid transcriptional and enzymatic regulation in the central nervous system.\u003c\/p\u003e\n\u003cul data-path-to-node=\"22\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"22,0,0\"\u003e\u003cb data-path-to-node=\"22,0,0\" data-index-in-node=\"0\"\u003eNeurotrophic Upregulation:\u003c\/b\u003e Significantly increases the expression of \u003cb data-path-to-node=\"22,0,0\" data-index-in-node=\"69\"\u003eBDNF (Brain-Derived Neurotrophic Factor)\u003c\/b\u003e and \u003cb data-path-to-node=\"22,0,0\" data-index-in-node=\"114\"\u003eNGF (Nerve Growth Factor)\u003c\/b\u003e in the hippocampus and cortex. This promotes neuronal survival, synaptic plasticity, and axonal growth.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"22,1,0\"\u003e\u003cb data-path-to-node=\"22,1,0\" data-index-in-node=\"0\"\u003eTranscriptomic Reset:\u003c\/b\u003e In models of ischemia (stroke), Semax modulates the expression of over 1,500 genes. It specifically suppresses inflammatory gene clusters (e.g., \u003ci data-path-to-node=\"22,1,0\" data-index-in-node=\"167\"\u003eMmp9\u003c\/i\u003e, \u003ci data-path-to-node=\"22,1,0\" data-index-in-node=\"173\"\u003eNfkb\u003c\/i\u003e) while upregulating vascular and neurotransmitter genes, limiting the \"penumbra\" of damage.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"22,2,0\"\u003e\u003cb data-path-to-node=\"22,2,0\" data-index-in-node=\"0\"\u003eNeurotransmitter Balance:\u003c\/b\u003e Enhances dopaminergic and serotonergic signaling while inhibiting enkephalinases (enzymes that break down natural opioids), improving mood, focus, and pain tolerance.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003chr data-path-to-node=\"23\"\u003e\n\u003ch3 data-path-to-node=\"24\"\u003e\u003cb data-path-to-node=\"24\" data-index-in-node=\"0\"\u003eKey Research Applications\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp data-path-to-node=\"25\"\u003e\u003cb data-path-to-node=\"25\" data-index-in-node=\"0\"\u003e1. Stroke \u0026amp; Traumatic Brain Injury (TBI)\u003c\/b\u003e Semax is a primary candidate for neuroprotection. Clinical and preclinical data indicate it reduces infarct volume by up to \u003cb data-path-to-node=\"25\" data-index-in-node=\"165\"\u003e25%\u003c\/b\u003e and accelerates neurological recovery when administered in the acute phase of injury.\u003c\/p\u003e\n\u003cp data-path-to-node=\"26\"\u003e\u003cb data-path-to-node=\"26\" data-index-in-node=\"0\"\u003e2. Cognitive Enhancement (Nootropic)\u003c\/b\u003e Investigated for its ability to improve memory formation, attention span, and learning efficiency. It is used in research models of ADHD and developmental delay to normalize behavioral responses and cognitive processing.\u003c\/p\u003e\n\u003cp data-path-to-node=\"27\"\u003e\u003cb data-path-to-node=\"27\" data-index-in-node=\"0\"\u003e3. Ophthalmology (Retinal Protection)\u003c\/b\u003e Studies show Semax improves retinal microcirculation and electrical sensitivity of the optic nerve, making it a valuable tool for research into optic neuropathy, glaucoma, and diabetic retinopathy.\u003c\/p\u003e\n\u003chr data-path-to-node=\"28\"\u003e\n\u003ch3 data-path-to-node=\"29\"\u003e\u003cb data-path-to-node=\"29\" data-index-in-node=\"0\"\u003eStorage \u0026amp; Handling\u003c\/b\u003e\u003c\/h3\u003e\n\u003cul data-path-to-node=\"30\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"30,0,0\"\u003e\u003cb data-path-to-node=\"30,0,0\" data-index-in-node=\"0\"\u003ePhysical State:\u003c\/b\u003e Lyophilized (Freeze-Dried) White Powder.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"30,1,0\"\u003e\u003cb data-path-to-node=\"30,1,0\" data-index-in-node=\"0\"\u003eStorage (Powder):\u003c\/b\u003e Store at -20°C (Freezer). Stable for up to 24 months.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"30,2,0\"\u003e\u003cb data-path-to-node=\"30,2,0\" data-index-in-node=\"0\"\u003eReconstitution:\u003c\/b\u003e\u003c\/p\u003e\n\u003cul data-path-to-node=\"30,2,1\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"30,2,1,0,0\"\u003e\u003cb data-path-to-node=\"30,2,1,0,0\" data-index-in-node=\"0\"\u003eSolvent:\u003c\/b\u003e Sterile Water or Bacteriostatic Water.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"30,2,1,1,0\"\u003e\u003cb data-path-to-node=\"30,2,1,1,0\" data-index-in-node=\"0\"\u003eSolubility:\u003c\/b\u003e Highly soluble (\u0026gt;2mg\/mL).\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"30,3,0\"\u003e\u003cb data-path-to-node=\"30,3,0\" data-index-in-node=\"0\"\u003eStorage (Liquid):\u003c\/b\u003e Store at 4°C (Refrigerator). \u003cb data-path-to-node=\"30,3,0\" data-index-in-node=\"47\"\u003eUse within 14-21 days.\u003c\/b\u003e Semax degrades over time in solution; aliquoting and freezing is recommended for long-term experiments.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003chr data-path-to-node=\"31\"\u003e\n\u003ch3 data-path-to-node=\"32\"\u003e\u003cb data-path-to-node=\"32\" data-index-in-node=\"0\"\u003eDisclaimer\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp data-path-to-node=\"33\"\u003e\u003cb data-path-to-node=\"33\" data-index-in-node=\"0\"\u003eFOR RESEARCH USE ONLY.\u003c\/b\u003e This product is a chemical compound intended strictly for laboratory research and development. It is not approved by the FDA for clinical use, diagnostics, or therapeutic procedures in humans or animals. The physiological and toxicological properties of this chemical have not been fully investigated.\u003c\/p\u003e","brand":"Peptagon","offers":[{"title":"Default Title","offer_id":47712591118550,"sku":"SEMAX-30","price":50.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0783\/3085\/5638\/files\/Semax-30mg.png?v=1768507779"},{"product_id":"thymagen-thymomimetic-dipeptide-research-peptide","title":"Thymagen Research Peptide – 20mg","description":"\u003ch4 data-path-to-node=\"13\"\u003e\u003cstrong\u003eThymogen Peptide (Lyophilized)\u003c\/strong\u003e\u003c\/h4\u003e\n\u003cp data-path-to-node=\"14\"\u003e\u003cb data-path-to-node=\"14\" data-index-in-node=\"0\"\u003eSequence:\u003c\/b\u003e L-Glu-L-Trp (EW) \u003cb data-path-to-node=\"14\" data-index-in-node=\"27\"\u003eFormat:\u003c\/b\u003e Sterile Lyophilized Powder (Vial) \u003cb data-path-to-node=\"14\" data-index-in-node=\"69\"\u003eClass:\u003c\/b\u003e Thymic Bioregulator \/ Immunomodulator \u003cb data-path-to-node=\"14\" data-index-in-node=\"114\"\u003ePurity:\u003c\/b\u003e \u0026gt;98% (HPLC) \u003cb data-path-to-node=\"14\" data-index-in-node=\"134\"\u003eContent:\u003c\/b\u003e 20mg per vial\u003c\/p\u003e\n\u003chr data-path-to-node=\"15\"\u003e\n\u003ch3 data-path-to-node=\"16\"\u003e\u003cb data-path-to-node=\"16\" data-index-in-node=\"0\"\u003eProduct Overview\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp data-path-to-node=\"17\"\u003e\u003cb data-path-to-node=\"17\" data-index-in-node=\"0\"\u003eThymogen\u003c\/b\u003e is a synthetic dipeptide (Glutamic Acid - Tryptophan) developed as a bioregulator to mimic the natural signaling of the thymus gland. Originally isolated from thymic extracts, this stabilized dipeptide acts as a \"thymomimetic,\" signaling the maturation and differentiation of T-cells even when thymic function is compromised by age or stress.\u003c\/p\u003e\n\u003cp data-path-to-node=\"18\"\u003eThymogen is unique in its ability to normalize immune function—boosting suppressed immunity while stabilizing hyper-inflammatory states—without the immunogenicity of larger proteins. It is widely researched for its role in reversing immunosenescence and modulating the innate immune response via Toll-like receptors.\u003c\/p\u003e\n\u003chr data-path-to-node=\"19\"\u003e\n\u003ch3 data-path-to-node=\"20\"\u003e\u003cb data-path-to-node=\"20\" data-index-in-node=\"0\"\u003eMechanism of Action: The Immune Architect\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp data-path-to-node=\"21\"\u003eThymogen operates at the genetic and cellular level to restore immune homeostasis.\u003c\/p\u003e\n\u003cul data-path-to-node=\"22\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"22,0,0\"\u003e\u003cb data-path-to-node=\"22,0,0\" data-index-in-node=\"0\"\u003eT-Cell Maturation:\u003c\/b\u003e Stimulates the differentiation of hematopoietic stem cells into functional CD3+, CD4+, and CD8+ T-lymphocytes via the \u003cb data-path-to-node=\"22,0,0\" data-index-in-node=\"137\"\u003eNotch signaling pathway\u003c\/b\u003e.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"22,1,0\"\u003e\u003cb data-path-to-node=\"22,1,0\" data-index-in-node=\"0\"\u003eInnate Activation:\u003c\/b\u003e Upregulates the expression of \u003cb data-path-to-node=\"22,1,0\" data-index-in-node=\"49\"\u003eToll-like Receptors (TLR3, 7, 8, 9)\u003c\/b\u003e and cytoplasmic sensors (RIG-I), enhancing the body's ability to detect and respond to viral pathogens.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"22,2,0\"\u003e\u003cb data-path-to-node=\"22,2,0\" data-index-in-node=\"0\"\u003eEpigenetic Regulation:\u003c\/b\u003e Acts as a Khavinson peptide, penetrating the nucleus to modulate gene expression related to cytokine synthesis and DNA repair, effectively slowing the rate of thymic involution (atrophy).\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003chr data-path-to-node=\"23\"\u003e\n\u003ch3 data-path-to-node=\"24\"\u003e\u003cb data-path-to-node=\"24\" data-index-in-node=\"0\"\u003eKey Research Applications\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp data-path-to-node=\"25\"\u003e\u003cb data-path-to-node=\"25\" data-index-in-node=\"0\"\u003e1. Immunosenescence \u0026amp; Aging\u003c\/b\u003e Thymogen is a primary candidate for \"geroprotection\" research. Studies indicate it can restore T-cell populations in aged models, countering the natural decline of the immune system and improving resistance to infections.\u003c\/p\u003e\n\u003cp data-path-to-node=\"26\"\u003e\u003cb data-path-to-node=\"26\" data-index-in-node=\"0\"\u003e2. Viral Defense \u0026amp; Respiratory Health\u003c\/b\u003e Investigated for its virucidal properties and ability to prime the innate immune system. In vitro studies show it inhibits the replication of respiratory viruses (RSV, Influenza) by activating the MyD88\/IRAK1 signaling cascade.\u003c\/p\u003e\n\u003cp data-path-to-node=\"27\"\u003e\u003cb data-path-to-node=\"27\" data-index-in-node=\"0\"\u003e3. Autoimmunity \u0026amp; Inflammation\u003c\/b\u003e Research suggests Thymogen acts as an immunocorrector, normalizing the CD4\/CD8 ratio and suppressing excessive pro-inflammatory cytokines (TNF-alpha, IL-6) in conditions like chronic inflammation or autoimmune disorders.\u003c\/p\u003e\n\u003chr data-path-to-node=\"28\"\u003e\n\u003ch3 data-path-to-node=\"29\"\u003e\u003cb data-path-to-node=\"29\" data-index-in-node=\"0\"\u003eStorage \u0026amp; Handling\u003c\/b\u003e\u003c\/h3\u003e\n\u003cul data-path-to-node=\"30\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"30,0,0\"\u003e\u003cb data-path-to-node=\"30,0,0\" data-index-in-node=\"0\"\u003ePhysical State:\u003c\/b\u003e Lyophilized (Freeze-Dried) White Powder.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"30,1,0\"\u003e\u003cb data-path-to-node=\"30,1,0\" data-index-in-node=\"0\"\u003eStorage (Powder):\u003c\/b\u003e Store at -20°C (Freezer). Stable for up to 36 months.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"30,2,0\"\u003e\u003cb data-path-to-node=\"30,2,0\" data-index-in-node=\"0\"\u003eReconstitution:\u003c\/b\u003e\u003c\/p\u003e\n\u003cul data-path-to-node=\"30,2,1\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"30,2,1,0,0\"\u003e\u003cb data-path-to-node=\"30,2,1,0,0\" data-index-in-node=\"0\"\u003eSolvent:\u003c\/b\u003e Bacteriostatic Water or Sterile Saline.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"30,2,1,1,0\"\u003e\u003cb data-path-to-node=\"30,2,1,1,0\" data-index-in-node=\"0\"\u003eSolubility:\u003c\/b\u003e Highly soluble in water (\u0026gt;10mg\/mL).\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"30,3,0\"\u003e\u003cb data-path-to-node=\"30,3,0\" data-index-in-node=\"0\"\u003eStorage (Liquid):\u003c\/b\u003e Store at 4°C (Refrigerator). \u003cb data-path-to-node=\"30,3,0\" data-index-in-node=\"47\"\u003eUse within 2-4 weeks.\u003c\/b\u003e Avoid freeze-thaw cycles.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003chr data-path-to-node=\"31\"\u003e\n\u003ch3 data-path-to-node=\"32\"\u003e\u003cb data-path-to-node=\"32\" data-index-in-node=\"0\"\u003eDisclaimer\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp data-path-to-node=\"33\"\u003e\u003cb data-path-to-node=\"33\" data-index-in-node=\"0\"\u003eFOR RESEARCH USE ONLY.\u003c\/b\u003e This product is a chemical compound intended strictly for laboratory research and development. It is not approved by the FDA for clinical use, diagnostics, or therapeutic procedures in humans or animals. The physiological and toxicological properties of this chemical have not been fully investigated.\u003c\/p\u003e","brand":"Peptagon","offers":[{"title":"Default Title","offer_id":47712623853782,"sku":"THYMAGEN-20","price":38.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0783\/3085\/5638\/files\/Thymagen-20mg.png?v=1768508109"},{"product_id":"thymosin-alpha-1-thymalfasin-10mg-research-peptide","title":"Thymosin Alpha 1 Research Peptide – 10mg","description":"\u003ch4 data-path-to-node=\"13\"\u003e\u003cstrong\u003eThymosin Alpha 1 Peptide (Lyophilized)\u003c\/strong\u003e\u003c\/h4\u003e\n\u003cp data-path-to-node=\"14\"\u003e\u003cb data-path-to-node=\"14\" data-index-in-node=\"0\"\u003eSequence:\u003c\/b\u003e Ac-Ser-Asp-Ala-Ala-Val-Asp-Thr-Ser-Ser-Glu-Ile-Thr-Thr-Lys-Asp-Leu-Lys-Glu-Lys-Lys-Glu-Val-Val-Glu-Glu-Ala-Glu-Asn-OH \u003cb data-path-to-node=\"14\" data-index-in-node=\"128\"\u003eFormat:\u003c\/b\u003e Sterile Lyophilized Powder (Vial) \u003cb data-path-to-node=\"14\" data-index-in-node=\"170\"\u003eClass:\u003c\/b\u003e Biological Response Modifier (Thymic Peptide) \u003cb data-path-to-node=\"14\" data-index-in-node=\"223\"\u003ePurity:\u003c\/b\u003e \u0026gt;98% (HPLC) \u003cb data-path-to-node=\"14\" data-index-in-node=\"243\"\u003eContent:\u003c\/b\u003e 10mg per vial\u003c\/p\u003e\n\u003chr data-path-to-node=\"15\"\u003e\n\u003ch3 data-path-to-node=\"16\"\u003e\u003cb data-path-to-node=\"16\" data-index-in-node=\"0\"\u003eProduct Overview\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp data-path-to-node=\"17\"\u003e\u003cb data-path-to-node=\"17\" data-index-in-node=\"0\"\u003eThymosin Alpha 1 (TA1)\u003c\/b\u003e is a synthetic 28-amino acid peptide identical to the naturally occurring thymic hormone. It serves as a master regulator of the immune system, orchestrating the maturation of T-cells and the balance between innate and adaptive immunity.\u003c\/p\u003e\n\u003cp data-path-to-node=\"18\"\u003eTA1 is unique in its ability to restore immune function in immunocompromised states (e.g., aging, chronic infection) without causing the \"cytokine storms\" associated with non-specific immune boosters. It is widely researched for its role in fighting viral infections, enhancing vaccine efficacy, and serving as an adjunct in cancer immunotherapy.\u003c\/p\u003e\n\u003chr data-path-to-node=\"19\"\u003e\n\u003ch3 data-path-to-node=\"20\"\u003e\u003cb data-path-to-node=\"20\" data-index-in-node=\"0\"\u003eMechanism of Action: The Immune Conductor\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp data-path-to-node=\"21\"\u003eTA1 operates by activating key immune signaling pathways.\u003c\/p\u003e\n\u003cul data-path-to-node=\"22\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"22,0,0\"\u003e\u003cb data-path-to-node=\"22,0,0\" data-index-in-node=\"0\"\u003eTLR Activation:\u003c\/b\u003e Agonizes Toll-like Receptors (TLR9\/TLR2) on dendritic cells, triggering the \u003cb data-path-to-node=\"22,0,0\" data-index-in-node=\"92\"\u003eMyD88-IRAK1-NF-κB\u003c\/b\u003e signaling cascade. This primes the innate immune system to detect and destroy pathogens.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"22,1,0\"\u003e\u003cb data-path-to-node=\"22,1,0\" data-index-in-node=\"0\"\u003eT-Cell Maturation:\u003c\/b\u003e Stimulates the differentiation of progenitor cells into functional CD4+ and CD8+ T-cells via the \u003cb data-path-to-node=\"22,1,0\" data-index-in-node=\"116\"\u003eNotch signaling pathway\u003c\/b\u003e, reversing thymic involution (aging).\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"22,2,0\"\u003e\u003cb data-path-to-node=\"22,2,0\" data-index-in-node=\"0\"\u003eImmune Balance:\u003c\/b\u003e Modulates the Th1\/Th2 balance, promoting specific anti-viral\/anti-tumor responses (Th1) while preventing excessive inflammation via Regulatory T-cells (Tregs).\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003chr data-path-to-node=\"23\"\u003e\n\u003ch3 data-path-to-node=\"24\"\u003e\u003cb data-path-to-node=\"24\" data-index-in-node=\"0\"\u003eKey Research Applications\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp data-path-to-node=\"25\"\u003e\u003cb data-path-to-node=\"25\" data-index-in-node=\"0\"\u003e1. Infectious Disease ( Viral \u0026amp; Bacterial)\u003c\/b\u003e TA1 is extensively studied for its ability to reduce mortality in sepsis and severe respiratory infections. It boosts T-cell counts and clears viral antigens in chronic Hepatitis B and C, often used where other treatments fail.\u003c\/p\u003e\n\u003cp data-path-to-node=\"26\"\u003e\u003cb data-path-to-node=\"26\" data-index-in-node=\"0\"\u003e2. Cancer Immunotherapy\u003c\/b\u003e Acts as an adjuvant to checkpoint inhibitors (e.g., PD-1 blockers). Research shows it enhances antigen presentation, reduces chemotherapy-induced toxicity, and activates T-cells to attack tumors in melanoma and lung cancer models.\u003c\/p\u003e\n\u003cp data-path-to-node=\"27\"\u003e\u003cb data-path-to-node=\"27\" data-index-in-node=\"0\"\u003e3. Regenerative Medicine \u0026amp; Aging\u003c\/b\u003e Investigated for its ability to accelerate wound healing by promoting angiogenesis (new blood vessel growth) and keratinocyte migration. It also counters \"immunosenescence,\" the age-related decline of the immune system.\u003c\/p\u003e\n\u003chr data-path-to-node=\"28\"\u003e\n\u003ch3 data-path-to-node=\"29\"\u003e\u003cb data-path-to-node=\"29\" data-index-in-node=\"0\"\u003eStorage \u0026amp; Handling\u003c\/b\u003e\u003c\/h3\u003e\n\u003cul data-path-to-node=\"30\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"30,0,0\"\u003e\u003cb data-path-to-node=\"30,0,0\" data-index-in-node=\"0\"\u003ePhysical State:\u003c\/b\u003e Lyophilized (Freeze-Dried) White Powder.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"30,1,0\"\u003e\u003cb data-path-to-node=\"30,1,0\" data-index-in-node=\"0\"\u003eStorage (Powder):\u003c\/b\u003e Store at -20°C (Freezer). Stable for up to 36 months.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"30,2,0\"\u003e\u003cb data-path-to-node=\"30,2,0\" data-index-in-node=\"0\"\u003eReconstitution:\u003c\/b\u003e\u003c\/p\u003e\n\u003cul data-path-to-node=\"30,2,1\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"30,2,1,0,0\"\u003e\u003cb data-path-to-node=\"30,2,1,0,0\" data-index-in-node=\"0\"\u003eSolvent:\u003c\/b\u003e Sterile Water or Bacteriostatic Water.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"30,2,1,1,0\"\u003e\u003cb data-path-to-node=\"30,2,1,1,0\" data-index-in-node=\"0\"\u003eSolubility:\u003c\/b\u003e Highly soluble.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"30,3,0\"\u003e\u003cb data-path-to-node=\"30,3,0\" data-index-in-node=\"0\"\u003eStorage (Liquid):\u003c\/b\u003e Store at 4°C (Refrigerator). \u003cb data-path-to-node=\"30,3,0\" data-index-in-node=\"47\"\u003eUse within 7-14 days.\u003c\/b\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003chr data-path-to-node=\"31\"\u003e\n\u003ch3 data-path-to-node=\"32\"\u003e\u003cb data-path-to-node=\"32\" data-index-in-node=\"0\"\u003eDisclaimer\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp data-path-to-node=\"33\"\u003e\u003cb data-path-to-node=\"33\" data-index-in-node=\"0\"\u003eFOR RESEARCH USE ONLY.\u003c\/b\u003e This product is a chemical compound intended strictly for laboratory research and development. It is not approved by the FDA for clinical use, diagnostics, or therapeutic procedures in humans or animals. The physiological and toxicological properties of this chemical have not been fully investigated.\u003c\/p\u003e","brand":"Peptagon","offers":[{"title":"Default Title","offer_id":47712651280598,"sku":"TA1-10","price":38.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0783\/3085\/5638\/files\/Thymosin-Alpha-1-Peptide-_Thymalfasin_-10mg.png?v=1768836488"},{"product_id":"thymosin-alpha-1-thymulin-complex-research-peptide","title":"Thymosin Alpha 1 + Thymulin Research Peptide Blend – 10mg \/ 6.4mg","description":"\u003ch4 data-path-to-node=\"13\"\u003e\u003cstrong\u003eThymosin Alpha 1 + Thymulin Complex (Lyophilized)\u003c\/strong\u003e\u003c\/h4\u003e\n\u003cp data-path-to-node=\"14\"\u003e\u003cb data-path-to-node=\"14\" data-index-in-node=\"0\"\u003eComposition:\u003c\/b\u003e Thymosin Alpha 1 (10mg) \/ Thymulin (6.4mg) \u003cb data-path-to-node=\"14\" data-index-in-node=\"56\"\u003eFormat:\u003c\/b\u003e Sterile Lyophilized Powder (Vial) \u003cb data-path-to-node=\"14\" data-index-in-node=\"98\"\u003eRatio:\u003c\/b\u003e Optimized Synergistic Blend \u003cb data-path-to-node=\"14\" data-index-in-node=\"133\"\u003ePurity:\u003c\/b\u003e \u0026gt;98% (HPLC) \u003cb data-path-to-node=\"14\" data-index-in-node=\"153\"\u003eTotal Content:\u003c\/b\u003e 16.4mg per vial\u003c\/p\u003e\n\u003chr data-path-to-node=\"15\"\u003e\n\u003ch3 data-path-to-node=\"16\"\u003e\u003cb data-path-to-node=\"16\" data-index-in-node=\"0\"\u003eProduct Overview\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp data-path-to-node=\"17\"\u003eThis \u003cb data-path-to-node=\"17\" data-index-in-node=\"5\"\u003eThymic Peptide Complex\u003c\/b\u003e combines two of the most potent bioregulators derived from the thymus gland: \u003cb data-path-to-node=\"17\" data-index-in-node=\"105\"\u003eThymosin Alpha 1 (TA1)\u003c\/b\u003e and \u003cb data-path-to-node=\"17\" data-index-in-node=\"132\"\u003eThymulin (FTS)\u003c\/b\u003e.\u003c\/p\u003e\n\u003cp data-path-to-node=\"18\"\u003eWhile TA1 acts as a powerful modulator of innate immunity via Toll-like receptors, Thymulin functions as a zinc-dependent neuroendocrine regulator that drives T-cell differentiation. This synergistic 10mg\/6.4mg formulation is designed to investigate the complete restoration of the thymic axis, addressing both immune competence and neuroendocrine homeostasis in models of aging and chronic infection.\u003c\/p\u003e\n\u003chr data-path-to-node=\"19\"\u003e\n\u003ch3 data-path-to-node=\"20\"\u003e\u003cb data-path-to-node=\"20\" data-index-in-node=\"0\"\u003eMechanism of Action: The Dual Thymic Axis\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp data-path-to-node=\"21\"\u003eThis blend targets two distinct but complementary pathways of immune regulation.\u003c\/p\u003e\n\u003cul data-path-to-node=\"22\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"22,0,0\"\u003e\u003cb data-path-to-node=\"22,0,0\" data-index-in-node=\"0\"\u003eThymosin Alpha 1 (The TLR Agonist):\u003c\/b\u003e Activates \u003cb data-path-to-node=\"22,0,0\" data-index-in-node=\"46\"\u003eTLR9\/TLR2\u003c\/b\u003e on dendritic cells, triggering the MyD88 signaling cascade. This primes the innate immune system to detect pathogens and tumor antigens without causing excessive inflammation.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"22,1,0\"\u003e\u003cb data-path-to-node=\"22,1,0\" data-index-in-node=\"0\"\u003eThymulin (The Zinc Sensor):\u003c\/b\u003e Requires zinc to become biologically active. Once complexed, it binds to receptors on T-cells to promote their maturation into functional CD4+ and CD8+ subsets. It also acts on the neuroendocrine system to reduce inflammation via \u003cb data-path-to-node=\"22,1,0\" data-index-in-node=\"258\"\u003ep38 MAPK inhibition\u003c\/b\u003e.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"22,2,0\"\u003e\u003cb data-path-to-node=\"22,2,0\" data-index-in-node=\"0\"\u003eSynergy:\u003c\/b\u003e Together, they restore the \"thymic microenvironment,\" reversing the effects of thymic involution (atrophy) and boosting the body's ability to fight chronic viral infections and autoimmunity.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003chr data-path-to-node=\"23\"\u003e\n\u003ch3 data-path-to-node=\"24\"\u003e\u003cb data-path-to-node=\"24\" data-index-in-node=\"0\"\u003eKey Research Applications\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp data-path-to-node=\"25\"\u003e\u003cb data-path-to-node=\"25\" data-index-in-node=\"0\"\u003e1. Immunosenescence \u0026amp; Aging\u003c\/b\u003e The decline of thymic function is a primary driver of aging. This complex is researched for its ability to restore the production of naive T-cells, reversing the \"biological clock\" of the immune system and improving vaccine response in the elderly.\u003c\/p\u003e\n\u003cp data-path-to-node=\"26\"\u003e\u003cb data-path-to-node=\"26\" data-index-in-node=\"0\"\u003e2. Chronic Viral Infections (Hep B\/C, HIV)\u003c\/b\u003e TA1 is a standard therapy for Hepatitis B\/C. The addition of Thymulin is investigated for its ability to further enhance T-cell reactivity and reverse immune exhaustion (PD-1 expression) in chronic viral models.\u003c\/p\u003e\n\u003cp data-path-to-node=\"27\"\u003e\u003cb data-path-to-node=\"27\" data-index-in-node=\"0\"\u003e3. Neuroinflammation \u0026amp; Pain\u003c\/b\u003e Thymulin possesses potent anti-inflammatory and analgesic properties in the central nervous system. It reduces glial cell activation and proinflammatory cytokines, offering potential neuroprotective benefits in neurodegenerative research.\u003c\/p\u003e\n\u003chr data-path-to-node=\"28\"\u003e\n\u003ch3 data-path-to-node=\"29\"\u003e\u003cb data-path-to-node=\"29\" data-index-in-node=\"0\"\u003eStorage \u0026amp; Handling\u003c\/b\u003e\u003c\/h3\u003e\n\u003cul data-path-to-node=\"30\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"30,0,0\"\u003e\u003cb data-path-to-node=\"30,0,0\" data-index-in-node=\"0\"\u003ePhysical State:\u003c\/b\u003e Lyophilized (Freeze-Dried) White Powder.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"30,1,0\"\u003e\u003cb data-path-to-node=\"30,1,0\" data-index-in-node=\"0\"\u003eStorage (Powder):\u003c\/b\u003e Store at -20°C (Freezer). Stable for up to 24 months.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"30,2,0\"\u003e\u003cb data-path-to-node=\"30,2,0\" data-index-in-node=\"0\"\u003eReconstitution:\u003c\/b\u003e\u003c\/p\u003e\n\u003cul data-path-to-node=\"30,2,1\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"30,2,1,0,0\"\u003e\u003cb data-path-to-node=\"30,2,1,0,0\" data-index-in-node=\"0\"\u003eSolvent:\u003c\/b\u003e Bacteriostatic Water or Sterile Saline.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"30,2,1,1,0\"\u003e\u003cb data-path-to-node=\"30,2,1,1,0\" data-index-in-node=\"0\"\u003eNote:\u003c\/b\u003e Thymulin activity is zinc-dependent; standard culture media usually contain sufficient zinc, but in vivo research may require monitoring zinc status.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"30,3,0\"\u003e\u003cb data-path-to-node=\"30,3,0\" data-index-in-node=\"0\"\u003eStorage (Liquid):\u003c\/b\u003e Store at 4°C (Refrigerator). \u003cb data-path-to-node=\"30,3,0\" data-index-in-node=\"47\"\u003eUse within 21 days.\u003c\/b\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003chr data-path-to-node=\"31\"\u003e\n\u003ch3 data-path-to-node=\"32\"\u003e\u003cb data-path-to-node=\"32\" data-index-in-node=\"0\"\u003eDisclaimer\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp data-path-to-node=\"33\"\u003e\u003cb data-path-to-node=\"33\" data-index-in-node=\"0\"\u003eFOR RESEARCH USE ONLY.\u003c\/b\u003e This product is a chemical compound intended strictly for laboratory research and development. It is not approved by the FDA for clinical use, diagnostics, or therapeutic procedures in humans or animals. The physiological and toxicological properties of this chemical have not been fully investigated.\u003c\/p\u003e","brand":"Peptagon","offers":[{"title":"Default Title","offer_id":47712651739350,"sku":"TA1THY-16.4","price":100.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0783\/3085\/5638\/files\/Thymosin-Alpha-1-Complex-Thymulin-10mg-6.4mg.png?v=1768508198"},{"product_id":"tb-500-thymosin-beta-4-research-peptide","title":"Thymosin Beta 4 Research Peptide – 10mg","description":"\u003ch4 data-path-to-node=\"13\"\u003e\u003cstrong\u003eTB-500 Peptide (Lyophilized)\u003c\/strong\u003e\u003c\/h4\u003e\n\u003cp data-path-to-node=\"14\"\u003e\u003cb data-path-to-node=\"14\" data-index-in-node=\"0\"\u003eSequence:\u003c\/b\u003e Ac-Ser-Asp-Lys-Pro-Asp-Met-Ala-Glu-Ile-Glu-Lys-Phe-Asp-Lys-Ser-Lys-Leu-Lys-Lys-Thr-Glu-Thr-Gln-Glu-Lys-Asn-Pro-Leu-Pro-Ser-Lys-Glu-Thr-Ile-Glu-Gln-Glu-Lys-Gln-Ala-Gly-Glu-Ser-OH \u003cb data-path-to-node=\"14\" data-index-in-node=\"188\"\u003eFormat:\u003c\/b\u003e Sterile Lyophilized Powder (Vial) \u003cb data-path-to-node=\"14\" data-index-in-node=\"230\"\u003eClass:\u003c\/b\u003e G-Actin Sequestering Peptide \u003cb data-path-to-node=\"14\" data-index-in-node=\"266\"\u003ePurity:\u003c\/b\u003e \u0026gt;98% (HPLC) \u003cb data-path-to-node=\"14\" data-index-in-node=\"286\"\u003eContent:\u003c\/b\u003e 5mg or 10mg per vial\u003c\/p\u003e\n\u003chr data-path-to-node=\"15\"\u003e\n\u003ch3 data-path-to-node=\"16\"\u003e\u003cb data-path-to-node=\"16\" data-index-in-node=\"0\"\u003eProduct Overview\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp data-path-to-node=\"17\"\u003e\u003cb data-path-to-node=\"17\" data-index-in-node=\"0\"\u003eTB-500\u003c\/b\u003e is a synthetic version of the naturally occurring peptide \u003cb data-path-to-node=\"17\" data-index-in-node=\"65\"\u003eThymosin Beta-4 (Tβ4)\u003c\/b\u003e. Found in high concentrations in almost all tissue types, Tβ4 is the primary molecule responsible for regulating cytoskeletal dynamics via G-actin sequestration.\u003c\/p\u003e\n\u003cp data-path-to-node=\"18\"\u003eTB-500 is widely researched for its potent regenerative capabilities. By maintaining the pool of actin monomers required for cell motility, it facilitates rapid tissue repair, angiogenesis (new blood vessel formation), and the modulation of inflammation in skin, heart, and neural tissues.\u003c\/p\u003e\n\u003chr data-path-to-node=\"19\"\u003e\n\u003ch3 data-path-to-node=\"20\"\u003e\u003cb data-path-to-node=\"20\" data-index-in-node=\"0\"\u003eMechanism of Action: The Cellular Architect\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp data-path-to-node=\"21\"\u003eTB-500 operates through distinct intracellular and extracellular pathways to drive regeneration.\u003c\/p\u003e\n\u003cul data-path-to-node=\"22\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"22,0,0\"\u003e\u003cb data-path-to-node=\"22,0,0\" data-index-in-node=\"0\"\u003eG-Actin Sequestration:\u003c\/b\u003e The peptide contains a conserved \u003cb data-path-to-node=\"22,0,0\" data-index-in-node=\"56\"\u003eLKKTET\u003c\/b\u003e motif that binds to G-actin (monomeric actin). This prevents premature polymerization, maintaining a \"ready pool\" of actin monomers essential for rapid cell migration and wound closure.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"22,1,0\"\u003e\u003cb data-path-to-node=\"22,1,0\" data-index-in-node=\"0\"\u003eNotch \u0026amp; VEGF Signaling:\u003c\/b\u003e Upregulates \u003cb data-path-to-node=\"22,1,0\" data-index-in-node=\"36\"\u003eNotch1\u003c\/b\u003e and \u003cb data-path-to-node=\"22,1,0\" data-index-in-node=\"47\"\u003eHIF-1α\u003c\/b\u003e, promoting angiogenesis and vascular repair, particularly under hypoxic (low oxygen) conditions.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"22,2,0\"\u003e\u003cb data-path-to-node=\"22,2,0\" data-index-in-node=\"0\"\u003eInflammation Control:\u003c\/b\u003e Inhibits the \u003cb data-path-to-node=\"22,2,0\" data-index-in-node=\"35\"\u003eNF-κB pathway\u003c\/b\u003e, reducing the expression of pro-inflammatory cytokines like IL-8 and promoting the transition of macrophages to a pro-repair (M2) phenotype.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003chr data-path-to-node=\"23\"\u003e\n\u003ch3 data-path-to-node=\"24\"\u003e\u003cb data-path-to-node=\"24\" data-index-in-node=\"0\"\u003eKey Research Applications\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp data-path-to-node=\"25\"\u003e\u003cb data-path-to-node=\"25\" data-index-in-node=\"0\"\u003e1. Dermal Wound Healing\u003c\/b\u003e TB-500 significantly accelerates wound closure. Research in rat models demonstrates a \u003cb data-path-to-node=\"25\" data-index-in-node=\"110\"\u003e42% improvement in re-epithelialization\u003c\/b\u003e by day 4 and improved collagen organization, reducing scarring.\u003c\/p\u003e\n\u003cp data-path-to-node=\"26\"\u003e\u003cb data-path-to-node=\"26\" data-index-in-node=\"0\"\u003e2. Cardiovascular Regeneration\u003c\/b\u003e In models of myocardial infarction (heart attack), TB-500 administration reduces cardiac rupture and inflammatory infiltration. It reactivates embryonic coronary development programs, promoting the growth of new blood vessels in damaged heart tissue.\u003c\/p\u003e\n\u003cp data-path-to-node=\"27\"\u003e\u003cb data-path-to-node=\"27\" data-index-in-node=\"0\"\u003e3. Neuroprotection \u0026amp; Remyelination\u003c\/b\u003e Investigated for its ability to mobilize Oligodendrocyte Progenitor Cells (OPCs) in the brain. Studies show it can enhance functional recovery in models of demyelination and neurotrauma.\u003c\/p\u003e\n\u003chr data-path-to-node=\"28\"\u003e\n\u003ch3 data-path-to-node=\"29\"\u003e\u003cb data-path-to-node=\"29\" data-index-in-node=\"0\"\u003eStorage \u0026amp; Handling\u003c\/b\u003e\u003c\/h3\u003e\n\u003cul data-path-to-node=\"30\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"30,0,0\"\u003e\u003cb data-path-to-node=\"30,0,0\" data-index-in-node=\"0\"\u003ePhysical State:\u003c\/b\u003e Lyophilized (Freeze-Dried) White Powder.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"30,1,0\"\u003e\u003cb data-path-to-node=\"30,1,0\" data-index-in-node=\"0\"\u003eStorage (Powder):\u003c\/b\u003e Store at -20°C (Freezer). Stable for up to 3 weeks at room temperature, but long-term freezer storage is required.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"30,2,0\"\u003e\u003cb data-path-to-node=\"30,2,0\" data-index-in-node=\"0\"\u003eReconstitution:\u003c\/b\u003e\u003c\/p\u003e\n\u003cul data-path-to-node=\"30,2,1\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"30,2,1,0,0\"\u003e\u003cb data-path-to-node=\"30,2,1,0,0\" data-index-in-node=\"0\"\u003eSolvent:\u003c\/b\u003e Bacteriostatic Water (0.9% Benzyl Alcohol).\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"30,2,1,1,0\"\u003e\u003cb data-path-to-node=\"30,2,1,1,0\" data-index-in-node=\"0\"\u003eSolubility:\u003c\/b\u003e Highly soluble due to high glutamate\/lysine content.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"30,3,0\"\u003e\u003cb data-path-to-node=\"30,3,0\" data-index-in-node=\"0\"\u003eStorage (Liquid):\u003c\/b\u003e Store at 4°C (Refrigerator). \u003cb data-path-to-node=\"30,3,0\" data-index-in-node=\"47\"\u003eUse within 2-7 days.\u003c\/b\u003e\u003c\/p\u003e\n\u003cul data-path-to-node=\"30,3,1\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"30,3,1,0,0\"\u003e\u003ci data-path-to-node=\"30,3,1,0,0\" data-index-in-node=\"0\"\u003eNote:\u003c\/i\u003e For longer storage of reconstituted peptide, the addition of a carrier protein (0.1% HSA or BSA) is recommended to prevent degradation.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003chr data-path-to-node=\"31\"\u003e\n\u003ch3 data-path-to-node=\"32\"\u003e\u003cb data-path-to-node=\"32\" data-index-in-node=\"0\"\u003eDisclaimer\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp data-path-to-node=\"33\"\u003e\u003cb data-path-to-node=\"33\" data-index-in-node=\"0\"\u003eFOR RESEARCH USE ONLY.\u003c\/b\u003e This product is a chemical compound intended strictly for laboratory research and development. It is not approved by the FDA for clinical use, diagnostics, or therapeutic procedures in humans or animals. The physiological and toxicological properties of this chemical have not been fully investigated.\u003c\/p\u003e","brand":"Peptagon","offers":[{"title":"10mg","offer_id":47712656359638,"sku":"TB500-10","price":41.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0783\/3085\/5638\/files\/Thymosin-Beta-4-10mg_1.png?v=1778247602"},{"product_id":"wolverine-blend-bpc-157-tb500-research-peptide-blend","title":"Wolverine Blend Research Peptide Blend – 10mg \/ 10mg","description":"\u003ch4 data-path-to-node=\"13\"\u003e\u003cstrong\u003eThe Wolverine Blend (Lyophilized)\u003c\/strong\u003e\u003c\/h4\u003e\n\u003cp data-path-to-node=\"14\"\u003e\u003cb data-path-to-node=\"14\" data-index-in-node=\"0\"\u003eComposition:\u003c\/b\u003e BPC-157 (10mg) \/ TB-500 (10mg) \u003cb data-path-to-node=\"14\" data-index-in-node=\"44\"\u003eFormat:\u003c\/b\u003e Sterile Lyophilized Powder (Vial) \u003cb data-path-to-node=\"14\" data-index-in-node=\"86\"\u003eRatio:\u003c\/b\u003e 1:1 Synergistic Blend \u003cb data-path-to-node=\"14\" data-index-in-node=\"115\"\u003ePurity:\u003c\/b\u003e \u0026gt;98% (HPLC) \u003cb data-path-to-node=\"14\" data-index-in-node=\"135\"\u003eTotal Content:\u003c\/b\u003e 20mg per vial\u003c\/p\u003e\n\u003chr data-path-to-node=\"15\"\u003e\n\u003ch3 data-path-to-node=\"16\"\u003e\u003cb data-path-to-node=\"16\" data-index-in-node=\"0\"\u003eProduct Overview\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp data-path-to-node=\"17\"\u003e\u003cb data-path-to-node=\"17\" data-index-in-node=\"0\"\u003eThe Wolverine Blend\u003c\/b\u003e is a premier research formulation combining two of the most potent regenerative peptides: \u003cb data-path-to-node=\"17\" data-index-in-node=\"110\"\u003eBody Protection Compound-157 (BPC-157)\u003c\/b\u003e and \u003cb data-path-to-node=\"17\" data-index-in-node=\"153\"\u003eThymosin Beta-4 (TB-500)\u003c\/b\u003e.\u003c\/p\u003e\n\u003cp data-path-to-node=\"18\"\u003eThis 1:1 blend (10mg each) leverages the complementary mechanisms of both peptides to accelerate \"inside-out\" healing. BPC-157 provides localized structural repair and vascular support, while TB-500 acts systemically to mobilize stem cells and reduce inflammation. Together, they create a comprehensive environment for rapid recovery from musculoskeletal injury and soft tissue damage.\u003c\/p\u003e\n\u003chr data-path-to-node=\"19\"\u003e\n\u003ch3 data-path-to-node=\"20\"\u003e\u003cb data-path-to-node=\"20\" data-index-in-node=\"0\"\u003eMechanism of Action: The Synergistic Repair\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp data-path-to-node=\"21\"\u003eThe Wolverine Blend targets multiple pathways of regeneration simultaneously.\u003c\/p\u003e\n\u003cul data-path-to-node=\"22\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"22,0,0\"\u003e\u003cb data-path-to-node=\"22,0,0\" data-index-in-node=\"0\"\u003eBPC-157 (The Vascular Architect):\u003c\/b\u003e Upregulates growth hormone receptors in tendon fibroblasts and activates the \u003cb data-path-to-node=\"22,0,0\" data-index-in-node=\"111\"\u003eFAK-Paxillin pathway\u003c\/b\u003e to speed up cell migration. It also stimulates angiogenesis (VEGF\/NO signaling) to restore blood flow to injured tissues.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"22,1,0\"\u003e\u003cb data-path-to-node=\"22,1,0\" data-index-in-node=\"0\"\u003eTB-500 (The Cellular Mobilizer):\u003c\/b\u003e Sequesters \u003cb data-path-to-node=\"22,1,0\" data-index-in-node=\"44\"\u003eG-actin\u003c\/b\u003e to facilitate rapid cell motility and wound closure. It activates the \u003cb data-path-to-node=\"22,1,0\" data-index-in-node=\"122\"\u003eNotch signaling pathway\u003c\/b\u003e to promote new blood vessel formation and modulates systemic inflammation by inhibiting NF-κB.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"22,2,0\"\u003e\u003cb data-path-to-node=\"22,2,0\" data-index-in-node=\"0\"\u003eSynergy:\u003c\/b\u003e BPC-157 stabilizes the repair site, while TB-500 recruits the necessary repair cells from the bone marrow, significantly enhancing the speed and quality of healing compared to either peptide alone.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003chr data-path-to-node=\"23\"\u003e\n\u003ch3 data-path-to-node=\"24\"\u003e\u003cb data-path-to-node=\"24\" data-index-in-node=\"0\"\u003eKey Research Applications\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp data-path-to-node=\"25\"\u003e\u003cb data-path-to-node=\"25\" data-index-in-node=\"0\"\u003e1. Musculoskeletal Injury Recovery\u003c\/b\u003e The gold standard for researching tendon, ligament, and muscle repair. Studies show the combination enhances load-to-failure strength in healed tendons and accelerates muscle regeneration after tears or atrophy.\u003c\/p\u003e\n\u003cp data-path-to-node=\"26\"\u003e\u003cb data-path-to-node=\"26\" data-index-in-node=\"0\"\u003e2. Post-Surgical Healing\u003c\/b\u003e Investigated for its ability to reduce recovery time and scarring following orthopedic surgeries. The blend promotes organized collagen deposition and reduces post-operative inflammation.\u003c\/p\u003e\n\u003cp data-path-to-node=\"27\"\u003e\u003cb data-path-to-node=\"27\" data-index-in-node=\"0\"\u003e3. Chronic Joint Health \u0026amp; Arthritis\u003c\/b\u003e Research indicates the blend protects chondrocytes (cartilage cells) and reduces pain in chronic joint conditions by modulating inflammatory cytokines and promoting synovial health.\u003c\/p\u003e\n\u003chr data-path-to-node=\"28\"\u003e\n\u003ch3 data-path-to-node=\"29\"\u003e\u003cb data-path-to-node=\"29\" data-index-in-node=\"0\"\u003eStorage \u0026amp; Handling\u003c\/b\u003e\u003c\/h3\u003e\n\u003cul data-path-to-node=\"30\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"30,0,0\"\u003e\u003cb data-path-to-node=\"30,0,0\" data-index-in-node=\"0\"\u003ePhysical State:\u003c\/b\u003e Lyophilized (Freeze-Dried) White Powder.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"30,1,0\"\u003e\u003cb data-path-to-node=\"30,1,0\" data-index-in-node=\"0\"\u003eStorage (Powder):\u003c\/b\u003e Store at -20°C (Freezer). Stable for up to 24 months.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"30,2,0\"\u003e\u003cb data-path-to-node=\"30,2,0\" data-index-in-node=\"0\"\u003eReconstitution:\u003c\/b\u003e\u003c\/p\u003e\n\u003cul data-path-to-node=\"30,2,1\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"30,2,1,0,0\"\u003e\u003cb data-path-to-node=\"30,2,1,0,0\" data-index-in-node=\"0\"\u003eSolvent:\u003c\/b\u003e Bacteriostatic Water or Sterile Saline.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"30,2,1,1,0\"\u003e\u003cb data-path-to-node=\"30,2,1,1,0\" data-index-in-node=\"0\"\u003eVolume:\u003c\/b\u003e Standard reconstitution with 2-4mL allows for precise split dosing.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"30,3,0\"\u003e\u003cb data-path-to-node=\"30,3,0\" data-index-in-node=\"0\"\u003eStorage (Liquid):\u003c\/b\u003e Store at 4°C (Refrigerator). \u003cb data-path-to-node=\"30,3,0\" data-index-in-node=\"47\"\u003eUse within 21-28 days.\u003c\/b\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003chr data-path-to-node=\"31\"\u003e\n\u003ch3 data-path-to-node=\"32\"\u003e\u003cb data-path-to-node=\"32\" data-index-in-node=\"0\"\u003eDisclaimer\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp data-path-to-node=\"33\"\u003e\u003cb data-path-to-node=\"33\" data-index-in-node=\"0\"\u003eFOR RESEARCH USE ONLY.\u003c\/b\u003e This product is a chemical compound intended strictly for laboratory research and development. It is not approved by the FDA for clinical use, diagnostics, or therapeutic procedures in humans or animals. The physiological and toxicological properties of this chemical have not been fully investigated.\u003c\/p\u003e","brand":"Peptagon","offers":[{"title":"Default Title","offer_id":47712683655382,"sku":"WOLV-10","price":56.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0783\/3085\/5638\/files\/Wolverine-Blend-BPC-157-10mg-TB500-10mg.png?v=1768508511"},{"product_id":"bpc-157-oral-500mcg-research-tablets","title":"BPC-157 Research Tablets – 500mcg – 30 Count","description":"\u003ch4 data-path-to-node=\"11\"\u003e\u003cstrong\u003eBPC-157 (Stable Gastric Pentadecapeptide)\u003c\/strong\u003e\u003c\/h4\u003e\n\u003cp data-path-to-node=\"12\"\u003e\u003cb data-path-to-node=\"12\" data-index-in-node=\"0\"\u003eSequence:\u003c\/b\u003e Gly-Glu-Pro-Pro-Pro-Gly-Lys-Pro-Ala-Asp-Asp-Ala-Gly-Leu-Val \u003cb data-path-to-node=\"12\" data-index-in-node=\"70\"\u003eFormat:\u003c\/b\u003e Oral Tablets (L-Arginine Salt) \u003cb data-path-to-node=\"12\" data-index-in-node=\"109\"\u003eClass:\u003c\/b\u003e Cytoprotective Regenerative Peptide \u003cb data-path-to-node=\"12\" data-index-in-node=\"152\"\u003ePurity:\u003c\/b\u003e ≥99% (HPLC) \u003cb data-path-to-node=\"12\" data-index-in-node=\"172\"\u003eContent:\u003c\/b\u003e 500mcg per tablet\u003c\/p\u003e\n\u003chr data-path-to-node=\"13\"\u003e\n\u003ch3 data-path-to-node=\"14\"\u003e\u003cb data-path-to-node=\"14\" data-index-in-node=\"0\"\u003eProduct Overview\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp data-path-to-node=\"15\"\u003e\u003cb data-path-to-node=\"15\" data-index-in-node=\"0\"\u003eBPC-157 (Body Protection Compound-157)\u003c\/b\u003e is a synthetic pentadecapeptide derived from a naturally occurring protein found in human gastric juice. It is a cornerstone of regenerative medicine research, recognized for its \"organoprotective\" capabilities across multiple physiological systems.\u003c\/p\u003e\n\u003cp data-path-to-node=\"16\"\u003eThis specific \u003cb data-path-to-node=\"16\" data-index-in-node=\"14\"\u003e500mcg Oral Formulation\u003c\/b\u003e utilizes the stable \u003cb data-path-to-node=\"16\" data-index-in-node=\"58\"\u003eL-Arginine salt form\u003c\/b\u003e. Unlike standard peptide acetate forms which degrade rapidly in the stomach, this specialized salt remains bioactive in gastric juice for over 24 hours. This makes it a premier tool for researching systemic tissue repair, gut-brain axis modulation, and the acceleration of musculoskeletal recovery via oral administration.\u003c\/p\u003e\n\u003chr data-path-to-node=\"17\"\u003e\n\u003ch3 data-path-to-node=\"18\"\u003e\u003cb data-path-to-node=\"18\" data-index-in-node=\"0\"\u003eMechanism of Action: The Cytoprotective Cascade\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp data-path-to-node=\"19\"\u003eBPC-157 operates by activating the body’s innate regenerative signaling pathways.\u003c\/p\u003e\n\u003cul data-path-to-node=\"20\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"20,0,0\"\u003e\u003cb data-path-to-node=\"20,0,0\" data-index-in-node=\"0\"\u003eAngiogenesis (VEGF Pathway):\u003c\/b\u003e Upregulates the expression of \u003cb data-path-to-node=\"20,0,0\" data-index-in-node=\"59\"\u003eVEGFR2\u003c\/b\u003e receptors (by \u0026gt;200%), triggering the formation of new blood vessels. This \"vascular rescue\" allows oxygen and nutrients to reach damaged tissues that traditionally have poor blood supply.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"20,1,0\"\u003e\u003cb data-path-to-node=\"20,1,0\" data-index-in-node=\"0\"\u003eGene Expression (EGR-1):\u003c\/b\u003e Rapidly stimulates \u003cb data-path-to-node=\"20,1,0\" data-index-in-node=\"44\"\u003eEarly Growth Response-1 (EGR-1)\u003c\/b\u003e, a master transcription factor that orchestrates the initial stages of the wound healing response.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"20,2,0\"\u003e\u003cb data-path-to-node=\"20,2,0\" data-index-in-node=\"0\"\u003eNitric Oxide (NO) Modulation:\u003c\/b\u003e Balances the NO system, acting as a buffer to maintain vascular integrity. It counteracts the damage caused by both excessive NO production and Nitric Oxide Synthase inhibition.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"20,3,0\"\u003e\u003cb data-path-to-node=\"20,3,0\" data-index-in-node=\"0\"\u003eFibroblast Activation:\u003c\/b\u003e Increases the expression of the \u003cb data-path-to-node=\"20,3,0\" data-index-in-node=\"55\"\u003eGrowth Hormone Receptor (GHR)\u003c\/b\u003e on tendon and ligament cells, making them hypersensitive to natural repair signals.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003chr data-path-to-node=\"21\"\u003e\n\u003ch3 data-path-to-node=\"22\"\u003e\u003cb data-path-to-node=\"22\" data-index-in-node=\"0\"\u003eKey Research Applications\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp data-path-to-node=\"23\"\u003e\u003cb data-path-to-node=\"23\" data-index-in-node=\"0\"\u003e1. Gastrointestinal Repair \u0026amp; IBD\u003c\/b\u003e Research focuses on its ability to heal gastric ulcers, internal fistulas, and \"leaky gut\" syndrome. It is the gold standard for investigating the reversal of mucosal damage caused by chronic NSAID use (e.g., Aspirin, Ibuprofen).\u003c\/p\u003e\n\u003cp data-path-to-node=\"24\"\u003e\u003cb data-path-to-node=\"24\" data-index-in-node=\"0\"\u003e2. Musculoskeletal Recovery\u003c\/b\u003e Investigated for its ability to dramatically accelerate the healing of tendons, ligaments, and muscle-to-bone reattachment. In animal models, BPC-157 has shown the ability to restore biomechanical strength to transected Achilles tendons.\u003c\/p\u003e\n\u003cp data-path-to-node=\"25\"\u003e\u003cb data-path-to-node=\"25\" data-index-in-node=\"0\"\u003e3. Neuroprotection \u0026amp; Gut-Brain Axis\u003c\/b\u003e By stabilizing the gut-brain axis, BPC-157 is researched for its ability to reduce brain edema after trauma and balance neurotransmitter systems (dopamine and serotonin), offering a potential model for treating neuroinflammatory conditions.\u003c\/p\u003e\n\u003chr data-path-to-node=\"26\"\u003e\n\u003ch3 data-path-to-node=\"27\"\u003e\u003cb data-path-to-node=\"27\" data-index-in-node=\"0\"\u003eStorage \u0026amp; Handling\u003c\/b\u003e\u003c\/h3\u003e\n\u003cul data-path-to-node=\"28\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"28,0,0\"\u003e\u003cb data-path-to-node=\"28,0,0\" data-index-in-node=\"0\"\u003ePhysical State:\u003c\/b\u003e Tablet form for stable oral research.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"28,1,0\"\u003e\u003cb data-path-to-node=\"28,1,0\" data-index-in-node=\"0\"\u003eStorage:\u003c\/b\u003e Store in a cool, dry place. The L-Arginine salt is stable at room temperature for several months.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"28,2,0\"\u003e\u003cb data-path-to-node=\"28,2,0\" data-index-in-node=\"0\"\u003eLong-Term Storage:\u003c\/b\u003e Store at 4°C (Refrigerator) to maintain maximum enzymatic resistance for up to 2 years.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003chr data-path-to-node=\"29\"\u003e\n\u003ch3 data-path-to-node=\"30\"\u003e\u003cb data-path-to-node=\"30\" data-index-in-node=\"0\"\u003eDisclaimer\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp data-path-to-node=\"31\"\u003e\u003cb data-path-to-node=\"31\" data-index-in-node=\"0\"\u003eFOR RESEARCH USE ONLY.\u003c\/b\u003e This product is a chemical compound intended strictly for laboratory research and development. It is not approved by the FDA for clinical use, diagnostics, or therapeutic procedures in humans or animals. The physiological and toxicological properties of this chemical have not been fully investigated.\u003c\/p\u003e","brand":"Peptagon","offers":[{"title":"Default Title","offer_id":47712685785302,"sku":"BPC157-500x30","price":79.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0783\/3085\/5638\/files\/BPC-157-_500mcg_-x-30-Tablets.png?v=1768835818"},{"product_id":"vip-bpc-157-oral-peptide-blend","title":"VIP + BPC-157 Research Tablets – 2mg \/ 500mcg – 30 Count","description":"\u003ch4 data-path-to-node=\"11\"\u003e\u003cstrong\u003eVIP \/ BPC-157: The Immunomodulatory \u0026amp; Regenerative Matrix\u003c\/strong\u003e\u003c\/h4\u003e\n\u003cp data-path-to-node=\"12\"\u003e\u003cb data-path-to-node=\"12\" data-index-in-node=\"0\"\u003eComposition:\u003c\/b\u003e Vasoactive Intestinal Peptide (2 mg) \/ BPC-157 (500 mcg) \u003cb data-path-to-node=\"12\" data-index-in-node=\"70\"\u003eFormat:\u003c\/b\u003e Oral Tablets \u003cb data-path-to-node=\"12\" data-index-in-node=\"91\"\u003eClass:\u003c\/b\u003e Pleiotropic Peptide Blend \u003cb data-path-to-node=\"12\" data-index-in-node=\"124\"\u003ePrimary Targets:\u003c\/b\u003e VPAC1\/2 Receptors, FAK-Paxillin Pathway, NF-κB Inhibition\u003c\/p\u003e\n\u003chr data-path-to-node=\"13\"\u003e\n\u003ch3 data-path-to-node=\"14\"\u003e\u003cb data-path-to-node=\"14\" data-index-in-node=\"0\"\u003eProduct Overview\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp data-path-to-node=\"15\"\u003eThis \u003cb data-path-to-node=\"15\" data-index-in-node=\"5\"\u003eVIP \/ BPC-157 Blend\u003c\/b\u003e represents a sophisticated experimental architecture designed to address the \"Inflammation-Regeneration Paradox.\" By combining a high-dose neuro-immunomodulator (VIP) with a cytoprotective structural organizer (BPC-157), this formulation targets two distinct biological axes simultaneously.\u003c\/p\u003e\n\u003cul data-path-to-node=\"16\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"16,0,0\"\u003e\u003cb data-path-to-node=\"16,0,0\" data-index-in-node=\"0\"\u003eThe VIP Component (2 mg):\u003c\/b\u003e A massive supraphysiological dose designed to saturate local proteolytic enzymes and target the \u003cb data-path-to-node=\"16,0,0\" data-index-in-node=\"122\"\u003eGut-Associated Lymphoid Tissue (GALT)\u003c\/b\u003e. This strategy aims to induce oral tolerance and modulate systemic inflammation via the enteric nervous system.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"16,1,0\"\u003e\u003cb data-path-to-node=\"16,1,0\" data-index-in-node=\"0\"\u003eThe BPC-157 Component (500 mcg):\u003c\/b\u003e A stable, gastric-resistant pentadecapeptide that acts as the regenerative backbone. It drives structural repair, collagen organization, and angiogenesis, ensuring that the anti-inflammatory environment created by VIP is utilized for tissue reconstruction.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003chr data-path-to-node=\"17\"\u003e\n\u003ch3 data-path-to-node=\"18\"\u003e\u003cb data-path-to-node=\"18\" data-index-in-node=\"0\"\u003eMechanism of Action: The \"Brake and Accelerator\" Synergy\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp data-path-to-node=\"19\"\u003eThis blend utilizes complementary signaling pathways to optimize the healing environment:\u003c\/p\u003e\n\u003cul data-path-to-node=\"20\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"20,0,0\"\u003e\u003cb data-path-to-node=\"20,0,0\" data-index-in-node=\"0\"\u003eVIP (The Anti-Inflammatory Brake):\u003c\/b\u003e Activates the \u003cb data-path-to-node=\"20,0,0\" data-index-in-node=\"49\"\u003ecAMP-PKA-CREB\u003c\/b\u003e pathway and directly inhibits \u003cb data-path-to-node=\"20,0,0\" data-index-in-node=\"93\"\u003eNF-κB\u003c\/b\u003e. By preventing the translocation of NF-κB to the nucleus, VIP suppresses the \"cytokine storm\" (TNF-α, IL-6) that often stalls healing in chronic wounds and autoimmune conditions.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"20,1,0\"\u003e\u003cb data-path-to-node=\"20,1,0\" data-index-in-node=\"0\"\u003eBPC-157 (The Regenerative Accelerator):\u003c\/b\u003e Once inflammation is controlled, BPC-157 activates the \u003cb data-path-to-node=\"20,1,0\" data-index-in-node=\"95\"\u003eFAK-Paxillin\u003c\/b\u003e pathway to drive fibroblast migration and the \u003cb data-path-to-node=\"20,1,0\" data-index-in-node=\"154\"\u003eVEGFR2-Akt-eNOS\u003c\/b\u003e axis to promote angiogenesis. This ensures a robust blood supply and the organized deposition of collagen types I and III.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"20,2,0\"\u003e\u003cb data-path-to-node=\"20,2,0\" data-index-in-node=\"0\"\u003eThe Gut-Brain Axis:\u003c\/b\u003e Both peptides modulate the enteric nervous system. VIP regulates epithelial barrier integrity and secretion, while BPC-157 repairs physical defects (ulcers, fistulas) and protects neurons from oxidative stress.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003chr data-path-to-node=\"21\"\u003e\n\u003ch3 data-path-to-node=\"22\"\u003e\u003cb data-path-to-node=\"22\" data-index-in-node=\"0\"\u003eKey Research Applications\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp data-path-to-node=\"23\"\u003e\u003cb data-path-to-node=\"23\" data-index-in-node=\"0\"\u003e1. Gastrointestinal Pathology (IBD \u0026amp; Fistulas)\u003c\/b\u003e Investigated for its ability to heal complex gut injuries. Research shows BPC-157 achieves \u003cb data-path-to-node=\"23\" data-index-in-node=\"138\"\u003e100% closure of gastrocutaneous fistulas\u003c\/b\u003e in animal models, while VIP reduces colonic inflammation and restores epithelial barrier function in colitis models.\u003c\/p\u003e\n\u003cp data-path-to-node=\"24\"\u003e\u003cb data-path-to-node=\"24\" data-index-in-node=\"0\"\u003e2. Musculoskeletal Repair (Tendons \u0026amp; Ligaments)\u003c\/b\u003e The blend is studied for its capacity to improve load-to-failure strength in healing tendons. BPC-157 promotes the alignment of collagen fibers, while VIP prevents the excessive, disorganized scarring (fibrosis) often driven by chronic inflammation.\u003c\/p\u003e\n\u003cp data-path-to-node=\"25\"\u003e\u003cb data-path-to-node=\"25\" data-index-in-node=\"0\"\u003e3. Pulmonary \u0026amp; Vascular Health\u003c\/b\u003e VIP is a potent vasodilator and anti-fibrotic agent in the lung. Research indicates it can reduce pulmonary vascular resistance and mitigate fibrosis in bleomycin-induced models. BPC-157 supports this by normalizing nitric oxide levels and protecting endothelial function.\u003c\/p\u003e\n\u003cp data-path-to-node=\"26\"\u003e\u003cb data-path-to-node=\"26\" data-index-in-node=\"0\"\u003e4. Systemic Autoimmunity\u003c\/b\u003e By targeting the GALT, high-dose oral VIP is researched for its ability to induce regulatory T-cells (Tregs) and shift the immune response away from a pro-inflammatory Th1 profile, offering potential in models of rheumatoid arthritis and multiple sclerosis.\u003c\/p\u003e\n\u003chr data-path-to-node=\"27\"\u003e\n\u003ch3 data-path-to-node=\"28\"\u003e\u003cb data-path-to-node=\"28\" data-index-in-node=\"0\"\u003eStorage \u0026amp; Handling\u003c\/b\u003e\u003c\/h3\u003e\n\u003cul data-path-to-node=\"29\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"29,0,0\"\u003e\u003cb data-path-to-node=\"29,0,0\" data-index-in-node=\"0\"\u003ePhysical State:\u003c\/b\u003e Oral research tablets.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"29,1,0\"\u003e\u003cb data-path-to-node=\"29,1,0\" data-index-in-node=\"0\"\u003eStorage:\u003c\/b\u003e Store in a cool, dry place away from direct sunlight and moisture.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"29,2,0\"\u003e\u003cb data-path-to-node=\"29,2,0\" data-index-in-node=\"0\"\u003eStability:\u003c\/b\u003e BPC-157 is inherently stable in gastric juice. The high dose of VIP compensates for enzymatic degradation, but the tablets should be kept desiccated to maintain potency.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003chr data-path-to-node=\"30\"\u003e\n\u003ch3 data-path-to-node=\"31\"\u003e\u003cb data-path-to-node=\"31\" data-index-in-node=\"0\"\u003eDisclaimer\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp data-path-to-node=\"32\"\u003e\u003cb data-path-to-node=\"32\" data-index-in-node=\"0\"\u003eFOR RESEARCH USE ONLY.\u003c\/b\u003e This product is a chemical compound intended strictly for laboratory research and development. It is not approved by the FDA for clinical use, diagnostics, or therapeutic procedures in humans or animals. The physiological and toxicological properties of this chemical have not been fully investigated.\u003c\/p\u003e","brand":"Peptagon","offers":[{"title":"Default Title","offer_id":47712776552662,"sku":"VIP-BPC-2-5x30","price":144.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0783\/3085\/5638\/files\/VIP_2mg_-BPC-157_500mcg_x30-Tablets_1.png?v=1768849935"}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0783\/3085\/5638\/collections\/Tissue_Extracellular_Matrix_Research_Collection.png?v=1781104241","url":"https:\/\/peptagon.com\/collections\/tissue-extracellular-matrix-research.oembed","provider":"Peptagon","version":"1.0","type":"link"}