{"product_id":"5-amino-1mq-50mg-x-60-tablets-5-amino-1mq-30mg-x-30-tablets-5-amino-1mq-15mg-x-60-tablets","title":"5-Amino-1MQ (Selective NNMT Inhibitor)","description":"\u003ch4 data-path-to-node=\"11\"\u003e\u003cstrong\u003e5-Amino-1-methylquinolinium (5-Amino-1MQ)\u003c\/strong\u003e\u003c\/h4\u003e\n\u003cp data-path-to-node=\"12\"\u003e\u003cb data-path-to-node=\"12\" data-index-in-node=\"0\"\u003eCore Molecule:\u003c\/b\u003e 5-amino-1-methylquinolin-1-ium \u003cb data-path-to-node=\"12\" data-index-in-node=\"46\"\u003eFormat:\u003c\/b\u003e Oral Tablets \u003cb data-path-to-node=\"12\" data-index-in-node=\"67\"\u003eMechanism:\u003c\/b\u003e Selective Nicotinamide N-methyltransferase (NNMT) Inhibitor \u003cb data-path-to-node=\"12\" data-index-in-node=\"138\"\u003ePurity:\u003c\/b\u003e ≥98% (HPLC) \u003cb data-path-to-node=\"12\" data-index-in-node=\"158\"\u003eSalt Form:\u003c\/b\u003e Iodide or Chloride\u003c\/p\u003e\n\u003chr data-path-to-node=\"13\"\u003e\n\u003ch3 data-path-to-node=\"14\"\u003e\u003cb data-path-to-node=\"14\" data-index-in-node=\"0\"\u003eProduct Overview\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp data-path-to-node=\"15\"\u003e\u003cb data-path-to-node=\"15\" data-index-in-node=\"0\"\u003e5-Amino-1MQ\u003c\/b\u003e is a first-in-class small molecule inhibitor designed to target \u003cb data-path-to-node=\"15\" data-index-in-node=\"76\"\u003eNicotinamide N-methyltransferase (NNMT)\u003c\/b\u003e, a cytosolic enzyme that acts as a master regulator of the cellular \"metabolic drain.\"\u003c\/p\u003e\n\u003cp data-path-to-node=\"16\"\u003eIn states of obesity and aging, NNMT is often overexpressed, leading to the excessive methylation and excretion of nicotinamide. By inhibiting this enzyme, 5-Amino-1MQ prevents the loss of these precursors, effectively redirecting them into the \u003cb data-path-to-node=\"16\" data-index-in-node=\"245\"\u003eNAD+ salvage pathway\u003c\/b\u003e. This results in elevated intracellular NAD+ levels, optimized mitochondrial function, and enhanced energy metabolism without affecting appetite or caloric intake.\u003c\/p\u003e\n\u003chr data-path-to-node=\"17\"\u003e\n\u003ch3 data-path-to-node=\"18\"\u003e\u003cb data-path-to-node=\"18\" data-index-in-node=\"0\"\u003eMechanism of Action: The NAD+ Preservation\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp data-path-to-node=\"19\"\u003e5-Amino-1MQ works by precisely blocking the catalytic pocket of the NNMT enzyme.\u003c\/p\u003e\n\u003cul data-path-to-node=\"20\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"20,0,0\"\u003e\u003cb data-path-to-node=\"20,0,0\" data-index-in-node=\"0\"\u003eMetabolic Rewiring:\u003c\/b\u003e By stopping the conversion of nicotinamide (NAM) into 1-methylnicotinamide (1-MNA), the cell is forced to recycle NAM into \u003cb data-path-to-node=\"20,0,0\" data-index-in-node=\"143\"\u003eNAD+\u003c\/b\u003e. This increases the activity of sirtuins (SIRT1) and PARPs, which are essential for DNA repair and longevity.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"20,1,0\"\u003e\u003cb data-path-to-node=\"20,1,0\" data-index-in-node=\"0\"\u003eLipogenesis Inhibition:\u003c\/b\u003e In adipose tissue, NNMT inhibition reduces lipid accumulation by \u003cb data-path-to-node=\"20,1,0\" data-index-in-node=\"89\"\u003eup to 70%\u003c\/b\u003e (in vitro), shifting the cell's priority from fat storage to energy expenditure.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"20,2,0\"\u003e\u003cb data-path-to-node=\"20,2,0\" data-index-in-node=\"0\"\u003eMuscle Stem Cell Rescue:\u003c\/b\u003e It has been shown to rejuvenate senescent muscle stem cells (muSCs), restoring the regenerative capacity of aged skeletal muscle and significantly increasing grip strength and torque in animal models.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003chr data-path-to-node=\"21\"\u003e\n\u003ch3 data-path-to-node=\"22\"\u003e\u003cb data-path-to-node=\"22\" data-index-in-node=\"0\"\u003eKey Research Applications\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp data-path-to-node=\"23\"\u003e\u003cb data-path-to-node=\"23\" data-index-in-node=\"0\"\u003e1. Metabolic Syndrome \u0026amp; Obesity\u003c\/b\u003e 5-Amino-1MQ is a primary candidate for researching weight loss that is independent of the central nervous system. In diet-induced obese models, it produced a \u003cb data-path-to-node=\"23\" data-index-in-node=\"190\"\u003e7-10% reduction in body weight\u003c\/b\u003e in just 11 days by increasing the basal metabolic rate.\u003c\/p\u003e\n\u003cp data-path-to-node=\"24\"\u003e\u003cb data-path-to-node=\"24\" data-index-in-node=\"0\"\u003e2. Muscle Regeneration \u0026amp; Sarcopenia\u003c\/b\u003e Investigated for its ability to reverse age-related muscle decline. Research demonstrates a \u003cb data-path-to-node=\"24\" data-index-in-node=\"128\"\u003e70% increase in peak torque\u003c\/b\u003e and a significant acceleration in healing following muscle injury in aged subjects.\u003c\/p\u003e\n\u003cp data-path-to-node=\"25\"\u003e\u003cb data-path-to-node=\"25\" data-index-in-node=\"0\"\u003e3. NAD+ Synergy\u003c\/b\u003e Because it \"plugs the leak\" of NAD+ precursors, 5-Amino-1MQ is frequently studied in combination with NAD+ boosters like NMN or NR to maximize cellular energy and mitochondrial health.\u003c\/p\u003e\n\u003cp data-path-to-node=\"26\"\u003e\u003cb data-path-to-node=\"26\" data-index-in-node=\"0\"\u003e4. Autoimmune Inflammation\u003c\/b\u003e Emerging research in conditions like Graves' orbitopathy shows that 5-Amino-1MQ can significantly reduce the production of pro-inflammatory cytokines (IL-6, IL-8) and suppress pathogenic tissue remodeling.\u003c\/p\u003e\n\u003chr data-path-to-node=\"27\"\u003e\n\u003ch3 data-path-to-node=\"28\"\u003e\u003cb data-path-to-node=\"28\" data-index-in-node=\"0\"\u003eStorage \u0026amp; Handling\u003c\/b\u003e\u003c\/h3\u003e\n\u003cul data-path-to-node=\"29\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"29,0,0\"\u003e\u003cb data-path-to-node=\"29,0,0\" data-index-in-node=\"0\"\u003ePhysical State:\u003c\/b\u003e Tablet form for precise experimental dosing.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"29,1,0\"\u003e\u003cb data-path-to-node=\"29,1,0\" data-index-in-node=\"0\"\u003eStorage:\u003c\/b\u003e Store in a cool, dry place. Long-term storage at -20°C is recommended to maintain maximum purity.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"29,2,0\"\u003e\u003cb data-path-to-node=\"29,2,0\" data-index-in-node=\"0\"\u003eStability:\u003c\/b\u003e Chemically stable at room temperature when protected from direct light and moisture.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003chr data-path-to-node=\"30\"\u003e\n\u003ch3 data-path-to-node=\"31\"\u003e\u003cb data-path-to-node=\"31\" data-index-in-node=\"0\"\u003eDisclaimer\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp data-path-to-node=\"32\"\u003e\u003cb data-path-to-node=\"32\" data-index-in-node=\"0\"\u003eFOR RESEARCH USE ONLY.\u003c\/b\u003e This product is a chemical compound intended strictly for laboratory research and development. It is not approved by the FDA for clinical use, diagnostics, or therapeutic procedures in humans or animals. The physiological and toxicological properties of this chemical have not been fully investigated.\u003c\/p\u003e","brand":"Peptagon","offers":[{"title":"15 mg (60 Tablets)","offer_id":47712684179670,"sku":"5A1-15x60","price":66.0,"currency_code":"USD","in_stock":true},{"title":"30 mg (30 Tablets)","offer_id":47712684212438,"sku":"5A1-30x30","price":110.0,"currency_code":"USD","in_stock":true},{"title":"50 mg (60 Tablets)","offer_id":47712684245206,"sku":"5A1-50x60","price":144.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0783\/3085\/5638\/files\/5-Amino-1mq-_15mg_-x-60-Tablets.png?v=1768836647","url":"https:\/\/peptagon.com\/products\/5-amino-1mq-50mg-x-60-tablets-5-amino-1mq-30mg-x-30-tablets-5-amino-1mq-15mg-x-60-tablets","provider":"Peptagon","version":"1.0","type":"link"}