{"product_id":"alpha-klotho-monoclonal-antibody-mab-2-vials","title":"α-Klotho Monoclonal Research Antibody – 10mcg – 2 Vials","description":"\u003ch1 data-section-id=\"16wv5b9\" data-start=\"305\" data-end=\"359\"\u003eα-Klotho Monoclonal Antibody (MAB) – 10mcg (2 Vials)\u003c\/h1\u003e\n\u003ch2 data-section-id=\"1qhk4i3\" data-start=\"361\" data-end=\"380\"\u003eSpecifications\u003c\/h2\u003e\n\u003cp data-start=\"381\" data-end=\"593\"\u003e\u003cstrong data-start=\"381\" data-end=\"392\"\u003eTarget:\u003c\/strong\u003e α-Klotho (KL1 \/ KL2 extracellular domains)\u003cbr data-start=\"435\" data-end=\"438\"\u003e\u003cstrong data-start=\"438\" data-end=\"449\"\u003eFormat:\u003c\/strong\u003e Monoclonal Antibody (IgG-based)\u003cbr data-start=\"481\" data-end=\"484\"\u003e\u003cstrong data-start=\"484\" data-end=\"497\"\u003eQuantity:\u003c\/strong\u003e 10mcg per vial (2 vials)\u003cbr data-start=\"522\" data-end=\"525\"\u003e\u003cstrong data-start=\"525\" data-end=\"535\"\u003eClass:\u003c\/strong\u003e Protein Interaction \/ Endocrine Signaling Research Tool\u003c\/p\u003e\n\u003cp data-start=\"595\" data-end=\"684\"\u003e\u003cstrong data-start=\"595\" data-end=\"612\"\u003eIntended Use:\u003c\/strong\u003e For laboratory research purposes only. Not for human or veterinary use.\u003c\/p\u003e\n\u003chr data-start=\"686\" data-end=\"689\"\u003e\n\u003ch2 data-section-id=\"53drpp\" data-start=\"691\" data-end=\"712\"\u003eProduct Overview\u003c\/h2\u003e\n\u003cp data-start=\"714\" data-end=\"940\"\u003eα-Klotho MAB is a research-grade monoclonal antibody designed to interact with the extracellular domains of the α-Klotho protein, a key regulator within the FGF23–Klotho signaling axis and broader endocrine signaling networks.\u003c\/p\u003e\n\u003cp data-start=\"942\" data-end=\"1077\"\u003eEach unit contains two vials (10mcg per vial), supporting controlled experimental design and reproducibility across research protocols.\u003c\/p\u003e\n\u003cp data-start=\"1079\" data-end=\"1477\"\u003eα-Klotho functions as a co-receptor protein that facilitates ligand-receptor interactions, particularly involving fibroblast growth factor 23 (FGF23) and FGFR complexes. Monoclonal antibodies targeting α-Klotho are utilized in preclinical research to investigate protein-protein interactions, receptor complex formation, and signaling pathway modulation in both soluble and membrane-bound contexts.\u003c\/p\u003e\n\u003cp data-start=\"1479\" data-end=\"1665\"\u003eThis antibody is applicable to studies involving renal signaling, mineral metabolism pathways, and cellular signaling processes associated with oxidative stress and endocrine regulation.\u003c\/p\u003e\n\u003chr data-start=\"1667\" data-end=\"1670\"\u003e\n\u003ch2 data-section-id=\"1msf7q0\" data-start=\"1672\" data-end=\"1695\"\u003eWhy This Antibody?\u003c\/h2\u003e\n\u003cp data-start=\"1697\" data-end=\"1896\"\u003eα-Klotho MAB is designed for high-specificity interaction with defined extracellular domains of the Klotho protein, enabling precise investigation of protein structure and signaling complex dynamics.\u003c\/p\u003e\n\u003cp data-start=\"1898\" data-end=\"1938\"\u003eThe monoclonal antibody format provides:\u003c\/p\u003e\n\u003cul data-start=\"1939\" data-end=\"2107\"\u003e\n\u003cli data-section-id=\"1s72ari\" data-start=\"1939\" data-end=\"2004\"\u003eConsistent binding specificity across experimental conditions\u003c\/li\u003e\n\u003cli data-section-id=\"1igudx3\" data-start=\"2005\" data-end=\"2046\"\u003eReliable targeting of KL1\/KL2 domains\u003c\/li\u003e\n\u003cli data-section-id=\"10k9fry\" data-start=\"2047\" data-end=\"2107\"\u003eUtility in both detection and functional pathway studies\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp data-start=\"2109\" data-end=\"2281\"\u003eThis makes it suitable for controlled analysis of Klotho protein interaction research, particularly within FGF23-dependent signaling systems and related endocrine pathways.\u003c\/p\u003e\n\u003chr data-start=\"2283\" data-end=\"2286\"\u003e\n\u003ch2 data-section-id=\"1gcermw\" data-start=\"2288\" data-end=\"2356\"\u003eMechanism of Action: Protein Interaction \u0026amp; Signaling Modulation\u003c\/h2\u003e\n\u003cp data-start=\"2358\" data-end=\"2489\"\u003eα-Klotho monoclonal antibodies are studied based on their interaction with structural and functional domains of the Klotho protein.\u003c\/p\u003e\n\u003cp data-start=\"2491\" data-end=\"2740\"\u003e\u003cstrong data-start=\"2491\" data-end=\"2522\"\u003eFGF23–Klotho Signaling Axis\u003c\/strong\u003e\u003cbr data-start=\"2522\" data-end=\"2525\"\u003eα-Klotho serves as an obligate co-receptor for FGF23, facilitating high-affinity binding to FGFR complexes. Antibody interaction may influence formation or stability of this signaling complex in experimental models.\u003c\/p\u003e\n\u003cp data-start=\"2742\" data-end=\"2962\"\u003e\u003cstrong data-start=\"2742\" data-end=\"2786\"\u003eExtracellular Domain Binding (KL1 \/ KL2)\u003c\/strong\u003e\u003cbr data-start=\"2786\" data-end=\"2789\"\u003eTargeting of extracellular domains allows investigation of both membrane-bound and soluble α-Klotho, supporting analysis of ligand binding and receptor interaction dynamics.\u003c\/p\u003e\n\u003cp data-start=\"2964\" data-end=\"3108\"\u003e\u003cstrong data-start=\"2964\" data-end=\"2994\"\u003eMAPK \/ ERK Pathway Context\u003c\/strong\u003e\u003cbr data-start=\"2994\" data-end=\"2997\"\u003eModulation of FGF23-dependent signaling has been evaluated in relation to downstream MAPK\/ERK pathway activity.\u003c\/p\u003e\n\u003cp data-start=\"3110\" data-end=\"3292\"\u003e\u003cstrong data-start=\"3110\" data-end=\"3141\"\u003eTGF-β Signaling Interaction\u003c\/strong\u003e\u003cbr data-start=\"3141\" data-end=\"3144\"\u003eα-Klotho has been studied in relation to TGF-β receptor pathways, providing a framework for examining Smad-mediated signaling and pathway crosstalk.\u003c\/p\u003e\n\u003cp data-start=\"3294\" data-end=\"3486\"\u003e\u003cstrong data-start=\"3294\" data-end=\"3335\"\u003eOxidative Stress \u0026amp; Cellular Signaling\u003c\/strong\u003e\u003cbr data-start=\"3335\" data-end=\"3338\"\u003eResearch involving α-Klotho includes investigation of pathways associated with oxidative stress response, including Nrf2 and FoxO signaling systems.\u003c\/p\u003e\n\u003chr data-start=\"3488\" data-end=\"3491\"\u003e\n\u003ch2 data-section-id=\"2op8d9\" data-start=\"3493\" data-end=\"3531\"\u003ePreclinical Research Applications\u003c\/h2\u003e\n\u003cp data-start=\"3533\" data-end=\"3664\"\u003e\u003cstrong data-start=\"3533\" data-end=\"3571\"\u003e1. FGF23–Klotho Signaling Research\u003c\/strong\u003e\u003cbr data-start=\"3571\" data-end=\"3574\"\u003eUsed to study receptor complex formation and signaling within mineral metabolism pathways.\u003c\/p\u003e\n\u003cp data-start=\"3666\" data-end=\"3822\"\u003e\u003cstrong data-start=\"3666\" data-end=\"3703\"\u003e2. Renal \u0026amp; Kidney Function Models\u003c\/strong\u003e\u003cbr data-start=\"3703\" data-end=\"3706\"\u003eApplied in preclinical models investigating α-Klotho expression, depletion, and signaling dynamics in renal systems.\u003c\/p\u003e\n\u003cp data-start=\"3824\" data-end=\"3990\"\u003e\u003cstrong data-start=\"3824\" data-end=\"3874\"\u003e3. Soluble α-Klotho Detection \u0026amp; Quantification\u003c\/strong\u003e\u003cbr data-start=\"3874\" data-end=\"3877\"\u003eUtilized in workflows involving immunoprecipitation, immunoblotting, and protein detection in biological samples.\u003c\/p\u003e\n\u003cp data-start=\"3992\" data-end=\"4126\"\u003e\u003cstrong data-start=\"3992\" data-end=\"4025\"\u003e4. Endocrine Signaling Models\u003c\/strong\u003e\u003cbr data-start=\"4025\" data-end=\"4028\"\u003eInvestigated in research involving systemic endocrine regulation and protein interaction networks.\u003c\/p\u003e\n\u003cp data-start=\"4128\" data-end=\"4247\"\u003e\u003cstrong data-start=\"4128\" data-end=\"4172\"\u003e5. Inflammation \u0026amp; NF-κB Pathway Research\u003c\/strong\u003e\u003cbr data-start=\"4172\" data-end=\"4175\"\u003eUsed in studies examining inflammatory signaling and pathway modulation.\u003c\/p\u003e\n\u003cp data-start=\"4249\" data-end=\"4384\"\u003e\u003cstrong data-start=\"4249\" data-end=\"4284\"\u003e6. Structural \u0026amp; Binding Studies\u003c\/strong\u003e\u003cbr data-start=\"4284\" data-end=\"4287\"\u003eSupports analysis of protein-protein interaction dynamics and receptor-ligand binding mechanisms.\u003c\/p\u003e\n\u003chr data-start=\"4386\" data-end=\"4389\"\u003e\n\u003ch2 data-section-id=\"ce0tqk\" data-start=\"4391\" data-end=\"4408\"\u003eApplications\u003c\/h2\u003e\n\u003cul data-start=\"4410\" data-end=\"4542\"\u003e\n\u003cli data-section-id=\"1iuqn3k\" data-start=\"4410\" data-end=\"4438\"\u003eImmunoprecipitation (IP)\u003c\/li\u003e\n\u003cli data-section-id=\"t1w30\" data-start=\"4439\" data-end=\"4472\"\u003eImmunoblotting (Western Blot)\u003c\/li\u003e\n\u003cli data-section-id=\"wtmzw9\" data-start=\"4473\" data-end=\"4503\"\u003eImmunohistochemistry (IHC)\u003c\/li\u003e\n\u003cli data-section-id=\"tund4r\" data-start=\"4504\" data-end=\"4542\"\u003eFlow Cytometry (variant dependent)\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003chr data-start=\"4544\" data-end=\"4547\"\u003e\n\u003ch2 data-section-id=\"1jtb6ys\" data-start=\"4549\" data-end=\"4573\"\u003eResearch Advantages\u003c\/h2\u003e\n\u003cul data-start=\"4575\" data-end=\"4910\"\u003e\n\u003cli data-section-id=\"1ltkoqj\" data-start=\"4575\" data-end=\"4630\"\u003eHigh specificity for α-Klotho extracellular domains\u003c\/li\u003e\n\u003cli data-section-id=\"18m2wvd\" data-start=\"4631\" data-end=\"4691\"\u003eApplicable to soluble and membrane-bound protein studies\u003c\/li\u003e\n\u003cli data-section-id=\"f0p27o\" data-start=\"4692\" data-end=\"4744\"\u003eSupports FGF23–Klotho signaling pathway analysis\u003c\/li\u003e\n\u003cli data-section-id=\"1cj8rdc\" data-start=\"4745\" data-end=\"4798\"\u003eCompatible with multiple laboratory assay systems\u003c\/li\u003e\n\u003cli data-section-id=\"1fwk0xb\" data-start=\"4799\" data-end=\"4858\"\u003eSuitable for protein interaction and signaling research\u003c\/li\u003e\n\u003cli data-section-id=\"dmxsnl\" data-start=\"4859\" data-end=\"4910\"\u003eNon-therapeutic, research-focused antibody tool\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003chr data-start=\"4912\" data-end=\"4915\"\u003e\n\u003ch2 data-section-id=\"1qk69px\" data-start=\"4917\" data-end=\"4940\"\u003eStorage \u0026amp; Handling\u003c\/h2\u003e\n\u003cp data-start=\"4942\" data-end=\"5035\"\u003e\u003cstrong data-start=\"4942\" data-end=\"4961\"\u003ePhysical State:\u003c\/strong\u003e Monoclonal antibody (solution or lyophilized format depending on batch)\u003c\/p\u003e\n\u003cp data-start=\"5037\" data-end=\"5085\"\u003e\u003cstrong data-start=\"5037\" data-end=\"5049\"\u003eStorage:\u003c\/strong\u003e Store at 2–8°C for short-term use\u003c\/p\u003e\n\u003cp data-start=\"5087\" data-end=\"5161\"\u003e\u003cstrong data-start=\"5087\" data-end=\"5109\"\u003eLong-Term Storage:\u003c\/strong\u003e Store at -20°C or below for extended preservation\u003c\/p\u003e\n\u003cp data-start=\"5163\" data-end=\"5241\"\u003e\u003cstrong data-start=\"5163\" data-end=\"5176\"\u003eHandling:\u003c\/strong\u003e Avoid repeated freeze-thaw cycles. Use aliquots where possible\u003c\/p\u003e\n\u003cp data-start=\"5243\" data-end=\"5305\"\u003e\u003cstrong data-start=\"5243\" data-end=\"5265\"\u003eLight Sensitivity:\u003c\/strong\u003e Protect from prolonged light exposure\u003c\/p\u003e\n\u003chr data-start=\"5307\" data-end=\"5310\"\u003e\n\u003ch2 data-section-id=\"9rcx7q\" data-start=\"5312\" data-end=\"5327\"\u003eDisclaimer\u003c\/h2\u003e\n\u003cp data-start=\"5329\" data-end=\"5653\"\u003eFOR RESEARCH USE ONLY. This product is a chemical compound intended strictly for laboratory research and development. It is not approved by the FDA for clinical use, diagnostics, or therapeutic procedures in humans or animals. The physiological and toxicological properties of this chemical have not been fully investigated.\u003c\/p\u003e","brand":"Peptagon","offers":[{"title":"Default Title","offer_id":48170187653334,"sku":"KLOTH-10-X2","price":631.0,"currency_code":"USD","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0783\/3085\/5638\/files\/a-KlothoMAB2pk_ca536a91-1d43-4247-a8e7-6c1adfdcbb94.png?v=1777487807","url":"https:\/\/peptagon.com\/products\/alpha-klotho-monoclonal-antibody-mab-2-vials","provider":"Peptagon","version":"1.0","type":"link"}