{"product_id":"aod-9604-tyr-hgh-177-191-research-peptide","title":"AOD 9604 Research Peptide – 6mg","description":"\u003ch4 data-path-to-node=\"13\"\u003e\u003cstrong\u003eAOD 9604 Peptide (Lyophilized)\u003c\/strong\u003e\u003c\/h4\u003e\n\u003cp data-path-to-node=\"14\"\u003e\u003cb data-path-to-node=\"14\" data-index-in-node=\"0\"\u003eSequence:\u003c\/b\u003e Tyr-Leu-Arg-Ile-Val-Gln-Cys-Arg-Ser-Val-Glu-Gly-Ser-Cys-Gly-Phe \u003cb data-path-to-node=\"14\" data-index-in-node=\"74\"\u003eFormat:\u003c\/b\u003e Sterile Lyophilized Powder (Vial) \u003cb data-path-to-node=\"14\" data-index-in-node=\"116\"\u003eConfiguration:\u003c\/b\u003e Cyclic (Disulfide Bridge Cys7-Cys14) \u003cb data-path-to-node=\"14\" data-index-in-node=\"168\"\u003ePurity:\u003c\/b\u003e \u0026gt;99% (HPLC) \u003cb data-path-to-node=\"14\" data-index-in-node=\"188\"\u003eContent:\u003c\/b\u003e 6mg per vial\u003c\/p\u003e\n\u003chr data-path-to-node=\"15\"\u003e\n\u003ch3 data-path-to-node=\"16\"\u003e\u003cb data-path-to-node=\"16\" data-index-in-node=\"0\"\u003eProduct Overview\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp data-path-to-node=\"17\"\u003e\u003cb data-path-to-node=\"17\" data-index-in-node=\"0\"\u003eAOD 9604\u003c\/b\u003e (Advanced Obesity Drug) is a synthetic hexadecapeptide representing the C-terminal lipolytic domain of Human Growth Hormone (hGH residues 177-191).\u003c\/p\u003e\n\u003cp data-path-to-node=\"18\"\u003eOriginally developed to isolate the fat-burning properties of hGH from its insulin-antagonistic effects, this peptide features an N-terminal Tyrosine \"cap\" and a cyclic disulfide bridge. These modifications stabilize the molecular structure, allowing it to mimic the amphipathic alpha-helix of the native hormone. Research indicates it is a potent regulator of lipid metabolism and cartilage regeneration without stimulating IGF-1 or inducing hyperglycemia.\u003c\/p\u003e\n\u003chr data-path-to-node=\"19\"\u003e\n\u003ch3 data-path-to-node=\"20\"\u003e\u003cb data-path-to-node=\"20\" data-index-in-node=\"0\"\u003eMechanism of Action: The \"Push-Pull\" Effect\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp data-path-to-node=\"21\"\u003eAOD 9604 operates through a distinct non-hGHR pathway, exerting a specific influence on adipocytes and mesenchymal tissues.\u003c\/p\u003e\n\u003ch4 data-path-to-node=\"22\"\u003e\u003cb data-path-to-node=\"22\" data-index-in-node=\"0\"\u003e1. Metabolic Regulation (Fat Loss)\u003c\/b\u003e\u003c\/h4\u003e\n\u003cp data-path-to-node=\"23\"\u003eThe peptide utilizes a \"Push-Pull\" mechanism on adipose tissue:\u003c\/p\u003e\n\u003cul data-path-to-node=\"24\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"24,0,0\"\u003e\u003cb data-path-to-node=\"24,0,0\" data-index-in-node=\"0\"\u003eStimulation of Lipolysis (The Push):\u003c\/b\u003e It upregulates \u003cb data-path-to-node=\"24,0,0\" data-index-in-node=\"52\"\u003eBeta-3 Adrenergic Receptors (β3-AR)\u003c\/b\u003e on fat cells, enhancing the sensitivity to endogenous fat-burning signals.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"24,1,0\"\u003e\u003cb data-path-to-node=\"24,1,0\" data-index-in-node=\"0\"\u003eInhibition of Lipogenesis (The Pull):\u003c\/b\u003e It inhibits \u003cb data-path-to-node=\"24,1,0\" data-index-in-node=\"50\"\u003eLipoprotein Lipase (LPL)\u003c\/b\u003e and \u003cb data-path-to-node=\"24,1,0\" data-index-in-node=\"79\"\u003eAcetyl-CoA Carboxylase (ACC)\u003c\/b\u003e, preventing the uptake of dietary fat and the synthesis of new triglycerides.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch4 data-path-to-node=\"25\"\u003e\u003cb data-path-to-node=\"25\" data-index-in-node=\"0\"\u003e2. Musculoskeletal Regeneration\u003c\/b\u003e\u003c\/h4\u003e\n\u003cp data-path-to-node=\"26\"\u003eRecent investigations (Kwon et al.) have identified AOD 9604 as a chondroprotective agent.\u003c\/p\u003e\n\u003cul data-path-to-node=\"27\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"27,0,0\"\u003e\u003cb data-path-to-node=\"27,0,0\" data-index-in-node=\"0\"\u003eCartilage Repair:\u003c\/b\u003e In models of osteoarthritis, the peptide enhanced the synthesis of Collagen Type II and proteoglycans.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"27,1,0\"\u003e\u003cb data-path-to-node=\"27,1,0\" data-index-in-node=\"0\"\u003eSynergy with Hyaluronic Acid (HA):\u003c\/b\u003e When co-administered with HA, AOD 9604 demonstrated superior efficacy in reducing lameness and structural damage compared to either agent alone.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003chr data-path-to-node=\"28\"\u003e\n\u003ch3 data-path-to-node=\"29\"\u003e\u003cb data-path-to-node=\"29\" data-index-in-node=\"0\"\u003eChemical Specifications\u003c\/b\u003e\u003c\/h3\u003e\n\u003cul data-path-to-node=\"30\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"30,0,0\"\u003e\u003cb data-path-to-node=\"30,0,0\" data-index-in-node=\"0\"\u003eMolecular Formula:\u003c\/b\u003e C78H123N23O23S2\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"30,1,0\"\u003e\u003cb data-path-to-node=\"30,1,0\" data-index-in-node=\"0\"\u003eMolecular Mass:\u003c\/b\u003e 1815.1 Da\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"30,2,0\"\u003e\u003cb data-path-to-node=\"30,2,0\" data-index-in-node=\"0\"\u003eStructural Stability:\u003c\/b\u003e The disulfide bond between Cysteine 7 and Cysteine 14 creates a rigid cyclic loop essential for receptor recognition. The N-terminal Tyrosine protects against enzymatic degradation by aminopeptidases.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003chr data-path-to-node=\"31\"\u003e\n\u003ch3 data-path-to-node=\"32\"\u003e\u003cb data-path-to-node=\"32\" data-index-in-node=\"0\"\u003eSafety Profile \u0026amp; Selectivity\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp data-path-to-node=\"33\"\u003eAOD 9604 is distinguished by its high safety profile in research settings. Unlike full-length hGH, AOD 9604:\u003c\/p\u003e\n\u003cul data-path-to-node=\"34\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"34,0,0\"\u003e\u003cb data-path-to-node=\"34,0,0\" data-index-in-node=\"0\"\u003eDoes NOT release IGF-1:\u003c\/b\u003e Eliminating the risk of acromegaly or proliferative tissue growth.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"34,1,0\"\u003e\u003cb data-path-to-node=\"34,1,0\" data-index-in-node=\"0\"\u003eDoes NOT induce Insulin Resistance:\u003c\/b\u003e It has no effect on blood glucose or insulin sensitivity.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"34,2,0\"\u003e\u003cb data-path-to-node=\"34,2,0\" data-index-in-node=\"0\"\u003eHigh Tolerability:\u003c\/b\u003e In human trials involving over 900 subjects, no anti-peptide antibodies or significant adverse events were reported.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003chr data-path-to-node=\"35\"\u003e\n\u003ch3 data-path-to-node=\"36\"\u003e\u003cb data-path-to-node=\"36\" data-index-in-node=\"0\"\u003eStorage \u0026amp; Handling\u003c\/b\u003e\u003c\/h3\u003e\n\u003cul data-path-to-node=\"37\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"37,0,0\"\u003e\u003cb data-path-to-node=\"37,0,0\" data-index-in-node=\"0\"\u003ePhysical State:\u003c\/b\u003e Lyophilized (Freeze-Dried) White Powder.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"37,1,0\"\u003e\u003cb data-path-to-node=\"37,1,0\" data-index-in-node=\"0\"\u003eStorage (Lyophilized):\u003c\/b\u003e Store at -20°C (Freezer). Stable for up to 24 months.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"37,2,0\"\u003e\u003cb data-path-to-node=\"37,2,0\" data-index-in-node=\"0\"\u003eReconstitution:\u003c\/b\u003e Use Bacteriostatic Water (0.9% Benzyl Alcohol) or Sterile Saline. Inject diluent slowly to avoid foaming. \u003cb data-path-to-node=\"37,2,0\" data-index-in-node=\"122\"\u003eDo not shake.\u003c\/b\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"37,3,0\"\u003e\u003cb data-path-to-node=\"37,3,0\" data-index-in-node=\"0\"\u003eStorage (Reconstituted):\u003c\/b\u003e Store at 4°C (Refrigerator). Use within 14-21 days.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003chr data-path-to-node=\"38\"\u003e\n\u003ch3 data-path-to-node=\"39\"\u003e\u003cb data-path-to-node=\"39\" data-index-in-node=\"0\"\u003eDisclaimer\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp data-path-to-node=\"40\"\u003e\u003cb data-path-to-node=\"40\" data-index-in-node=\"0\"\u003eFOR RESEARCH USE ONLY.\u003c\/b\u003e This product is a chemical compound intended strictly for laboratory research and development. It is not approved by the FDA for clinical use, diagnostics, or therapeutic procedures in humans or animals. The physiological and toxicological properties of this chemical have not been fully investigated.\u003c\/p\u003e","brand":"Peptagon","offers":[{"title":"Default Title","offer_id":47709709369558,"sku":"AOD9604-6","price":42.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0783\/3085\/5638\/files\/AOD-9604-6mg.png?v=1768514591","url":"https:\/\/peptagon.com\/products\/aod-9604-tyr-hgh-177-191-research-peptide","provider":"Peptagon","version":"1.0","type":"link"}