{"product_id":"ara-290-cibinetide-research-peptide","title":"ARA-290 Research Peptide – 14mg","description":"\u003ch4 data-path-to-node=\"13\"\u003e\u003cstrong\u003eARA-290 (Cibinetide) Peptide (Lyophilized)\u003c\/strong\u003e\u003c\/h4\u003e\n\u003cp data-path-to-node=\"14\"\u003e\u003cb data-path-to-node=\"14\" data-index-in-node=\"0\"\u003eSequence:\u003c\/b\u003e Glp-Glu-Gln-Leu-Glu-Arg-Ala-Leu-Asn-Ser-Ser \u003cb data-path-to-node=\"14\" data-index-in-node=\"54\"\u003eFormat:\u003c\/b\u003e Sterile Lyophilized Powder (Vial) \u003cb data-path-to-node=\"14\" data-index-in-node=\"96\"\u003eConfiguration:\u003c\/b\u003e Linear 11-mer (Pyroglutamate Modified) \u003cb data-path-to-node=\"14\" data-index-in-node=\"150\"\u003ePurity:\u003c\/b\u003e \u0026gt;99% (HPLC) \u003cb data-path-to-node=\"14\" data-index-in-node=\"170\"\u003eContent:\u003c\/b\u003e 14mg per vial\u003c\/p\u003e\n\u003chr data-path-to-node=\"15\"\u003e\n\u003ch3 data-path-to-node=\"16\"\u003e\u003cb data-path-to-node=\"16\" data-index-in-node=\"0\"\u003eProduct Overview\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp data-path-to-node=\"17\"\u003e\u003cb data-path-to-node=\"17\" data-index-in-node=\"0\"\u003eARA-290\u003c\/b\u003e, scientifically known as Cibinetide or Pyroglutamate Helix B Surface Peptide (pHBSP), is a synthetic 11-amino acid peptide engineered to harness the tissue-repair capabilities of Erythropoietin (EPO) without its blood-building side effects.\u003c\/p\u003e\n\u003cp data-path-to-node=\"18\"\u003eBy mimicking the 3D topography of EPO's Helix-B domain, ARA-290 acts as a highly selective agonist for the \u003cb data-path-to-node=\"18\" data-index-in-node=\"107\"\u003eInnate Repair Receptor (IRR)\u003c\/b\u003e. This receptor is transiently expressed only during tissue stress or injury. Consequently, ARA-290 activates potent anti-inflammatory and cytoprotective pathways selectively in damaged tissue, making it a primary subject of research for Small Fiber Neuropathy (SFN), Sarcoidosis, and metabolic dysregulation.\u003c\/p\u003e\n\u003chr data-path-to-node=\"19\"\u003e\n\u003ch3 data-path-to-node=\"20\"\u003e\u003cb data-path-to-node=\"20\" data-index-in-node=\"0\"\u003eMechanism of Action: Selective IRR Activation\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp data-path-to-node=\"21\"\u003eThe pharmacological value of ARA-290 lies in its receptor selectivity. It decouples the two primary functions of EPO:\u003c\/p\u003e\n\u003cul data-path-to-node=\"22\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"22,0,0\"\u003e\u003cb data-path-to-node=\"22,0,0\" data-index-in-node=\"0\"\u003eNo Hematopoietic Effect:\u003c\/b\u003e ARA-290 does \u003ci data-path-to-node=\"22,0,0\" data-index-in-node=\"38\"\u003enot\u003c\/i\u003e bind to the homodimeric EPO receptor (EPOR\/EPOR) responsible for red blood cell production. Therefore, it does not increase hematocrit or blood viscosity.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"22,1,0\"\u003e\u003cb data-path-to-node=\"22,1,0\" data-index-in-node=\"0\"\u003eTargeted Tissue Repair:\u003c\/b\u003e ARA-290 binds exclusively to the \u003cb data-path-to-node=\"22,1,0\" data-index-in-node=\"57\"\u003eInnate Repair Receptor (EPOR\/CD131)\u003c\/b\u003e. Activation of this complex triggers the downregulation of NF-κB (the master inflammatory switch) and the upregulation of SIRT1.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003chr data-path-to-node=\"23\"\u003e\n\u003ch3 data-path-to-node=\"24\"\u003e\u003cb data-path-to-node=\"24\" data-index-in-node=\"0\"\u003eKey Research Applications\u003c\/b\u003e\u003c\/h3\u003e\n\u003ch4 data-path-to-node=\"25\"\u003e\u003cb data-path-to-node=\"25\" data-index-in-node=\"0\"\u003e1. Small Fiber Neuropathy (SFN) \u0026amp; Neuroregeneration\u003c\/b\u003e\u003c\/h4\u003e\n\u003cp data-path-to-node=\"26\"\u003eARA-290 is unique in its ability to promote the structural regrowth of nerves.\u003c\/p\u003e\n\u003cul data-path-to-node=\"27\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"27,0,0\"\u003e\u003cb data-path-to-node=\"27,0,0\" data-index-in-node=\"0\"\u003eMechanism:\u003c\/b\u003e By suppressing perineural inflammation (TNF-α suppression) and shifting microglia to a reparative phenotype, it creates an environment permissive for axonal sprouting.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"27,1,0\"\u003e\u003cb data-path-to-node=\"27,1,0\" data-index-in-node=\"0\"\u003eClinical Evidence:\u003c\/b\u003e In Phase 2 trials involving Sarcoidosis patients, ARA-290 administration resulted in a significant increase in \u003cb data-path-to-node=\"27,1,0\" data-index-in-node=\"130\"\u003eCorneal Nerve Fiber Density (CNFD)\u003c\/b\u003e, providing objective anatomical proof of nerve regeneration.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch4 data-path-to-node=\"28\"\u003e\u003cb data-path-to-node=\"28\" data-index-in-node=\"0\"\u003e2. Chronic Inflammation \u0026amp; Autoimmunity\u003c\/b\u003e\u003c\/h4\u003e\n\u003cp data-path-to-node=\"29\"\u003eThe peptide targets the \u003cb data-path-to-node=\"29\" data-index-in-node=\"24\"\u003eSIRT1 \/ NF-κB Axis\u003c\/b\u003e.\u003c\/p\u003e\n\u003cul data-path-to-node=\"30\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"30,0,0\"\u003e\u003cb data-path-to-node=\"30,0,0\" data-index-in-node=\"0\"\u003eAction:\u003c\/b\u003e It reduces the acetylation of the NF-κB p65 subunit, effectively silencing the transcription of pro-inflammatory cytokines. This mechanism has been validated in models of autoimmune encephalomyelitis and apical periodontitis.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch4 data-path-to-node=\"31\"\u003e\u003cb data-path-to-node=\"31\" data-index-in-node=\"0\"\u003e3. Metabolic Syndrome (Type 2 Diabetes)\u003c\/b\u003e\u003c\/h4\u003e\n\u003cp data-path-to-node=\"32\"\u003eResearch in diabetic models indicates that ARA-290 may improve metabolic homeostasis. In human subjects with T2DM, treatment was associated with improved HbA1c levels and lipid profiles, suggesting that resolving systemic inflammation is a viable strategy for metabolic correction.\u003c\/p\u003e\n\u003chr data-path-to-node=\"33\"\u003e\n\u003ch3 data-path-to-node=\"34\"\u003e\u003cb data-path-to-node=\"34\" data-index-in-node=\"0\"\u003eChemical Specifications\u003c\/b\u003e\u003c\/h3\u003e\n\u003cul data-path-to-node=\"35\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"35,0,0\"\u003e\u003cb data-path-to-node=\"35,0,0\" data-index-in-node=\"0\"\u003eMolecular Formula:\u003c\/b\u003e C51H84N16O21\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"35,1,0\"\u003e\u003cb data-path-to-node=\"35,1,0\" data-index-in-node=\"0\"\u003eMolecular Mass:\u003c\/b\u003e 1257.3 Da\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"35,2,0\"\u003e\u003cb data-path-to-node=\"35,2,0\" data-index-in-node=\"0\"\u003eStructural Modifications:\u003c\/b\u003e The N-terminal residue is modified to \u003cb data-path-to-node=\"35,2,0\" data-index-in-node=\"64\"\u003ePyroglutamic Acid (Glp)\u003c\/b\u003e. This engineering choice confers significant resistance to aminopeptidase degradation, extending the peptide's plasma stability compared to native sequences.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003chr data-path-to-node=\"37\"\u003e\n\u003ch3 data-path-to-node=\"38\"\u003e\u003cb data-path-to-node=\"38\" data-index-in-node=\"0\"\u003eStorage \u0026amp; Handling\u003c\/b\u003e\u003c\/h3\u003e\n\u003cul data-path-to-node=\"39\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"39,0,0\"\u003e\u003cb data-path-to-node=\"39,0,0\" data-index-in-node=\"0\"\u003ePhysical State:\u003c\/b\u003e Lyophilized (Freeze-Dried) White Powder.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"39,1,0\"\u003e\u003cb data-path-to-node=\"39,1,0\" data-index-in-node=\"0\"\u003eStorage (Lyophilized):\u003c\/b\u003e Store at -20°C (Freezer). Stable for up to 24 months.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"39,2,0\"\u003e\u003cb data-path-to-node=\"39,2,0\" data-index-in-node=\"0\"\u003eReconstitution:\u003c\/b\u003e\u003c\/p\u003e\n\u003cul data-path-to-node=\"39,2,1\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"39,2,1,0,0\"\u003e\u003cb data-path-to-node=\"39,2,1,0,0\" data-index-in-node=\"0\"\u003eSolvent:\u003c\/b\u003e Sterile Water or Bacteriostatic Water.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"39,2,1,1,0\"\u003e\u003cb data-path-to-node=\"39,2,1,1,0\" data-index-in-node=\"0\"\u003eVolume Note:\u003c\/b\u003e This is a high-concentration \u003cb data-path-to-node=\"39,2,1,1,0\" data-index-in-node=\"42\"\u003e14mg\u003c\/b\u003e vial. To ensure complete dissolution, use at least \u003cb data-path-to-node=\"39,2,1,1,0\" data-index-in-node=\"98\"\u003e0.5mL - 1.0mL\u003c\/b\u003e of solvent. If using PBS, a larger volume (\u0026gt;5mL) may be required due to lower solubility in buffered salts.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"39,2,1,2,0\"\u003e\u003cb data-path-to-node=\"39,2,1,2,0\" data-index-in-node=\"0\"\u003epH:\u003c\/b\u003e If dissolution is slow, a slight adjustment to pH ~8.0 facilitates solubility.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"39,3,0\"\u003e\u003cb data-path-to-node=\"39,3,0\" data-index-in-node=\"0\"\u003eStorage (Reconstituted):\u003c\/b\u003e Store at 4°C (Refrigerator). Use within 7-14 days.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003chr data-path-to-node=\"40\"\u003e\n\u003ch3 data-path-to-node=\"41\"\u003e\u003cb data-path-to-node=\"41\" data-index-in-node=\"0\"\u003eDisclaimer\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp data-path-to-node=\"42\"\u003e\u003cb data-path-to-node=\"42\" data-index-in-node=\"0\"\u003eFOR RESEARCH USE ONLY.\u003c\/b\u003e This product is a chemical compound intended strictly for laboratory research and development. It is not approved by the FDA for clinical use, diagnostics, or therapeutic procedures in humans or animals. The physiological and toxicological properties of this chemical have not been fully investigated.\u003c\/p\u003e","brand":"Peptagon","offers":[{"title":"Default Title","offer_id":47709755965654,"sku":"ARA-14","price":69.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0783\/3085\/5638\/files\/ARA-290-14mg.png?v=1768505911","url":"https:\/\/peptagon.com\/products\/ara-290-cibinetide-research-peptide","provider":"Peptagon","version":"1.0","type":"link"}