{"product_id":"atx-304-o-304-pan-ampk-research-tablets","title":"ATX-304 Research Tablets – 100mg – 60 Count","description":"\u003ch1 data-section-id=\"u3jv4h\" data-start=\"339\" data-end=\"348\"\u003eATX-304\u003c\/h1\u003e\n\u003cp data-start=\"350\" data-end=\"376\"\u003e\u003cstrong data-start=\"350\" data-end=\"376\"\u003eATX-304 (O-304 \/ O304)\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp data-start=\"378\" data-end=\"678\"\u003e\u003cstrong data-start=\"378\" data-end=\"396\"\u003eChemical Name:\u003c\/strong\u003e 4-chloro-N-(2-(4-chlorobenzyl)-3-oxo-2,3-dihydro-1,2,4-thiadiazol-5-yl)benzamide\u003cbr data-start=\"477\" data-end=\"480\"\u003e\u003cstrong data-start=\"480\" data-end=\"488\"\u003eCAS:\u003c\/strong\u003e 1261289-04-6\u003cbr data-start=\"501\" data-end=\"504\"\u003e\u003cstrong data-start=\"504\" data-end=\"526\"\u003eMolecular Formula:\u003c\/strong\u003e C16H11Cl2N3O2S\u003cbr data-start=\"541\" data-end=\"544\"\u003e\u003cstrong data-start=\"544\" data-end=\"565\"\u003eMolecular Weight:\u003c\/strong\u003e 380.25 g\/mol\u003cbr data-start=\"578\" data-end=\"581\"\u003e\u003cstrong data-start=\"581\" data-end=\"592\"\u003eFormat:\u003c\/strong\u003e Oral Tablets\u003cbr data-start=\"605\" data-end=\"608\"\u003e\u003cstrong data-start=\"608\" data-end=\"618\"\u003eClass:\u003c\/strong\u003e Direct Pan-AMPK Activator \/ Metabolic Signaling Modulator\u003c\/p\u003e\n\u003cp data-start=\"680\" data-end=\"769\"\u003e\u003cstrong data-start=\"680\" data-end=\"697\"\u003eIntended Use:\u003c\/strong\u003e For laboratory research purposes only. Not for human or veterinary use.\u003c\/p\u003e\n\u003chr data-start=\"771\" data-end=\"774\"\u003e\n\u003ch2 data-section-id=\"1p927wt\" data-start=\"776\" data-end=\"795\"\u003eProduct Overview\u003c\/h2\u003e\n\u003cp data-start=\"797\" data-end=\"1163\"\u003eATX-304, also referenced in scientific literature as O-304 or O304, is a synthetic heterocyclic small molecule investigated for its role as a direct pan-activator of AMP-activated protein kinase (AMPK). Despite being grouped alongside peptide-based research compounds in some commercial contexts, ATX-304 is not a peptide and does not contain an amino acid sequence.\u003c\/p\u003e\n\u003cp data-start=\"1165\" data-end=\"1533\"\u003eAMPK functions as a central regulator of cellular energy homeostasis, coordinating responses to intracellular energy availability, mitochondrial activity, and metabolic demand. ATX-304 is utilized in preclinical research settings to investigate AMPK-dependent signaling pathways, metabolic regulation, and cellular adaptation processes under varying energy conditions.\u003c\/p\u003e\n\u003chr data-start=\"1535\" data-end=\"1538\"\u003e\n\u003ch2 data-section-id=\"knt4ug\" data-start=\"1540\" data-end=\"1564\"\u003eWhy This Formulation?\u003c\/h2\u003e\n\u003cp data-start=\"1566\" data-end=\"1757\"\u003eATX-304 is characterized by its small-molecule structure and oral research applicability, distinguishing it from earlier AMPK modulators with limited systemic exposure or isoform specificity.\u003c\/p\u003e\n\u003cp data-start=\"1759\" data-end=\"2169\"\u003eUnlike indirect AMPK activators that rely on altering cellular energy ratios, ATX-304 has been investigated for direct interaction with the AMPK complex and sustained modulation of its signaling activity across multiple isoforms. This makes it suitable for research involving systemic metabolic signaling, hepatic lipid metabolism pathways, renal cellular stress models, and skeletal muscle energy utilization.\u003c\/p\u003e\n\u003chr data-start=\"2171\" data-end=\"2174\"\u003e\n\u003ch2 data-section-id=\"f00cis\" data-start=\"2176\" data-end=\"2223\"\u003eMechanism of Action: AMPK Pathway Modulation\u003c\/h2\u003e\n\u003cp data-start=\"2225\" data-end=\"2321\"\u003eATX-304 has been studied for its interaction with AMPK signaling and related metabolic pathways.\u003c\/p\u003e\n\u003cp data-start=\"2323\" data-end=\"2615\"\u003e\u003cstrong data-start=\"2323\" data-end=\"2346\"\u003ePan-AMPK Activation\u003c\/strong\u003e\u003cbr data-start=\"2346\" data-end=\"2349\"\u003eATX-304 is investigated as a direct activator of AMPK across multiple heterotrimeric isoforms. Research suggests that it may contribute to maintaining phosphorylation at the AMPK α-subunit Thr172 site, a key regulatory component required for AMPK signaling activity.\u003c\/p\u003e\n\u003cp data-start=\"2617\" data-end=\"2828\"\u003e\u003cstrong data-start=\"2617\" data-end=\"2637\"\u003ePP2C Interaction\u003c\/strong\u003e\u003cbr data-start=\"2637\" data-end=\"2640\"\u003ePreclinical studies propose that ATX-304 may limit dephosphorylation of activated AMPK by protein phosphatase 2C (PP2C), thereby supporting sustained AMPK signaling in experimental models.\u003c\/p\u003e\n\u003cp data-start=\"2830\" data-end=\"3103\"\u003e\u003cstrong data-start=\"2830\" data-end=\"2870\"\u003eACC Phosphorylation \u0026amp; Lipid Pathways\u003c\/strong\u003e\u003cbr data-start=\"2870\" data-end=\"2873\"\u003eActivated AMPK phosphorylates acetyl-CoA carboxylase (ACC), a regulatory enzyme involved in fatty acid metabolism. ATX-304 has been investigated in models examining shifts between lipid synthesis and fatty acid oxidation pathways.\u003c\/p\u003e\n\u003cp data-start=\"3105\" data-end=\"3353\"\u003e\u003cstrong data-start=\"3105\" data-end=\"3145\"\u003eMitochondrial Activity \u0026amp; Energy Flux\u003c\/strong\u003e\u003cbr data-start=\"3145\" data-end=\"3148\"\u003eATX-304 has been studied in relation to mitochondrial respiration, oxygen consumption, and metabolic flux, including research exploring cellular responses to altered energy demand and oxidative conditions.\u003c\/p\u003e\n\u003cp data-start=\"3355\" data-end=\"3706\"\u003e\u003cstrong data-start=\"3355\" data-end=\"3384\"\u003eTranscriptional Signaling\u003c\/strong\u003e\u003cbr data-start=\"3384\" data-end=\"3387\"\u003eDownstream effects associated with AMPK activation include transcriptional regulation of pathways related to mitochondrial biogenesis, oxidative metabolism, and cellular stress response. ATX-304 has been evaluated in models examining signaling pathways involving PGC-1α, sirtuins, and lipid metabolism-associated genes.\u003c\/p\u003e\n\u003chr data-start=\"3708\" data-end=\"3711\"\u003e\n\u003ch2 data-section-id=\"1hv24wg\" data-start=\"3713\" data-end=\"3742\"\u003ePreclinical Research Areas\u003c\/h2\u003e\n\u003cp data-start=\"3744\" data-end=\"3936\"\u003e\u003cstrong data-start=\"3744\" data-end=\"3786\"\u003e1. AMPK Signaling \u0026amp; Energy Homeostasis\u003c\/strong\u003e\u003cbr data-start=\"3786\" data-end=\"3789\"\u003eATX-304 is utilized in research investigating AMPK as a regulator of cellular energy balance, nutrient sensing, and metabolic pathway coordination.\u003c\/p\u003e\n\u003cp data-start=\"3938\" data-end=\"4189\"\u003e\u003cstrong data-start=\"3938\" data-end=\"3989\"\u003e2. Hepatic Metabolism \u0026amp; Lipid Regulation Models\u003c\/strong\u003e\u003cbr data-start=\"3989\" data-end=\"3992\"\u003ePreclinical studies have evaluated ATX-304 in models examining hepatic lipid accumulation, cholesterol transport, and metabolic signaling associated with steatotic liver conditions.\u003cbr data-start=\"4173\" data-end=\"4176\"\u003e(Reference 1)\u003c\/p\u003e\n\u003cp data-start=\"4191\" data-end=\"4450\"\u003e\u003cstrong data-start=\"4191\" data-end=\"4226\"\u003e3. Renal Cellular Stress Models\u003c\/strong\u003e\u003cbr data-start=\"4226\" data-end=\"4229\"\u003eATX-304 has been studied in experimental models involving cisplatin-induced cellular stress, with focus on AMPK-dependent metabolic activity, mitochondrial function, and injury-response signaling pathways.\u003cbr data-start=\"4434\" data-end=\"4437\"\u003e(Reference 2)\u003c\/p\u003e\n\u003cp data-start=\"4452\" data-end=\"4670\"\u003e\u003cstrong data-start=\"4452\" data-end=\"4502\"\u003e4. Glucose Metabolism \u0026amp; Microvascular Research\u003c\/strong\u003e\u003cbr data-start=\"4502\" data-end=\"4505\"\u003eO304\/ATX-304 has been investigated in models assessing glucose utilization, skeletal muscle metabolic activity, and microvascular perfusion dynamics.\u003cbr data-start=\"4654\" data-end=\"4657\"\u003e(Reference 3)\u003c\/p\u003e\n\u003cp data-start=\"4672\" data-end=\"4909\"\u003e\u003cstrong data-start=\"4672\" data-end=\"4729\"\u003e5. Mitochondrial Function \u0026amp; Oxidative Stress Research\u003c\/strong\u003e\u003cbr data-start=\"4729\" data-end=\"4732\"\u003eDue to its interaction with AMPK signaling, ATX-304 is relevant in research exploring mitochondrial biogenesis, oxidative metabolism, and cellular responses to metabolic stress.\u003c\/p\u003e\n\u003chr data-start=\"4911\" data-end=\"4914\"\u003e\n\u003ch2 data-section-id=\"tslb7o\" data-start=\"4916\" data-end=\"4938\"\u003eResearch Advantages\u003c\/h2\u003e\n\u003cul data-start=\"4940\" data-end=\"5241\"\u003e\n\u003cli data-section-id=\"1ohi70l\" data-start=\"4940\" data-end=\"4991\"\u003eDirect interaction with AMPK signaling pathways\u003c\/li\u003e\n\u003cli data-section-id=\"2c0tq0\" data-start=\"4992\" data-end=\"5041\"\u003ePan-isoform AMPK activity (α1 \/ α2 complexes)\u003c\/li\u003e\n\u003cli data-section-id=\"15tupwk\" data-start=\"5042\" data-end=\"5073\"\u003eOral research applicability\u003c\/li\u003e\n\u003cli data-section-id=\"vpf6ox\" data-start=\"5074\" data-end=\"5116\"\u003eSmall-molecule structure (non-peptide)\u003c\/li\u003e\n\u003cli data-section-id=\"rjs9s8\" data-start=\"5117\" data-end=\"5173\"\u003eSuitable for long-duration metabolic research models\u003c\/li\u003e\n\u003cli data-section-id=\"af8sxl\" data-start=\"5174\" data-end=\"5241\"\u003eInvestigated across hepatic, renal, and skeletal muscle systems\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003chr data-start=\"5243\" data-end=\"5246\"\u003e\n\u003ch2 data-section-id=\"x99kj9\" data-start=\"5248\" data-end=\"5269\"\u003eStorage \u0026amp; Handling\u003c\/h2\u003e\n\u003cp data-start=\"5271\" data-end=\"5337\"\u003e\u003cstrong data-start=\"5271\" data-end=\"5290\"\u003ePhysical State:\u003c\/strong\u003e Tablet form for oral research administration\u003c\/p\u003e\n\u003cp data-start=\"5339\" data-end=\"5403\"\u003e\u003cstrong data-start=\"5339\" data-end=\"5351\"\u003eStorage:\u003c\/strong\u003e Store in a cool, dry place away from direct light\u003c\/p\u003e\n\u003cp data-start=\"5405\" data-end=\"5551\"\u003e\u003cstrong data-start=\"5405\" data-end=\"5427\"\u003eLong-Term Storage:\u003c\/strong\u003e Refrigerated storage recommended for extended stability. Avoid excessive heat, moisture, and repeated exposure to open air.\u003c\/p\u003e\n\u003chr data-start=\"5553\" data-end=\"5556\"\u003e\n\u003ch2 data-section-id=\"1g5aw3h\" data-start=\"5558\" data-end=\"5571\"\u003eDisclaimer\u003c\/h2\u003e\n\u003cp data-start=\"6070\" data-end=\"6394\"\u003eFOR RESEARCH USE ONLY. This product is a chemical compound intended strictly for laboratory research and development. It is not approved by the FDA for clinical use, diagnostics, or therapeutic procedures in humans or animals. The physiological and toxicological properties of this chemical have not been fully investigated.\u003c\/p\u003e","brand":"Peptagon","offers":[{"title":"Default Title","offer_id":48170116415702,"sku":"ATX304-100x60","price":155.0,"currency_code":"USD","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0783\/3085\/5638\/files\/ATX-304_100mg_-60tablets.png?v=1777476847","url":"https:\/\/peptagon.com\/products\/atx-304-o-304-pan-ampk-research-tablets","provider":"Peptagon","version":"1.0","type":"link"}