{"product_id":"bdnf-recombinant-brain-derived-neurotrophic-factor","title":"BDNF Research Protein – 10mg","description":"\u003ch4 data-path-to-node=\"13\"\u003e\u003cstrong\u003eBDNF (Brain-Derived Neurotrophic Factor) Recombinant\u003c\/strong\u003e\u003c\/h4\u003e\n\u003cp data-path-to-node=\"14\"\u003e\u003cb data-path-to-node=\"14\" data-index-in-node=\"0\"\u003eSequence:\u003c\/b\u003e Homodimer (Non-covalent) | Mature 119 AA Subunits \u003cb data-path-to-node=\"14\" data-index-in-node=\"60\"\u003eFormat:\u003c\/b\u003e Sterile Lyophilized Powder (Vial) \u003cb data-path-to-node=\"14\" data-index-in-node=\"102\"\u003eSource:\u003c\/b\u003e Recombinant (E. coli) \u003cb data-path-to-node=\"14\" data-index-in-node=\"132\"\u003ePurity:\u003c\/b\u003e \u0026gt;98% (SDS-PAGE \u0026amp; HPLC) \u003cb data-path-to-node=\"14\" data-index-in-node=\"163\"\u003eContent:\u003c\/b\u003e 10mg per vial\u003c\/p\u003e\n\u003chr data-path-to-node=\"15\"\u003e\n\u003ch3 data-path-to-node=\"16\"\u003e\u003cb data-path-to-node=\"16\" data-index-in-node=\"0\"\u003eProduct Overview\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp data-path-to-node=\"17\"\u003e\u003cb data-path-to-node=\"17\" data-index-in-node=\"0\"\u003eBrain-Derived Neurotrophic Factor (BDNF)\u003c\/b\u003e is the most widely distributed and thoroughly researched neurotrophin in the mammalian central nervous system. This high-purity recombinant formulation (10mg) is scaled for chronic \u003ci data-path-to-node=\"17\" data-index-in-node=\"222\"\u003ein vivo\u003c\/i\u003e research, metabolic profiling, and systemic administration protocols.\u003c\/p\u003e\n\u003cp data-path-to-node=\"18\"\u003eBDNF acts as a \"pleiotropic modulator,\" orchestrating neuronal survival, differentiation, and synaptic plasticity. It functions via a precise \"Yin and Yang\" mechanism: the mature protein (mBDNF) drives neuroprotection and spinogenesis via the \u003cb data-path-to-node=\"18\" data-index-in-node=\"243\"\u003eTrkB Receptor\u003c\/b\u003e, while its precursor (proBDNF) regulates synaptic pruning via the \u003cb data-path-to-node=\"18\" data-index-in-node=\"323\"\u003ep75NTR\u003c\/b\u003e. This research-grade formulation is optimized to contain high-purity mature protein to ensure robust TrkB activation.\u003c\/p\u003e\n\u003chr data-path-to-node=\"19\"\u003e\n\u003ch3 data-path-to-node=\"20\"\u003e\u003cb data-path-to-node=\"20\" data-index-in-node=\"0\"\u003eMechanism of Action: The TrkB Signaling Axis\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp data-path-to-node=\"21\"\u003eUpon binding to the Tropomyosin receptor kinase B (TrkB), BDNF triggers three canonical signaling cascades essential for neuroplasticity:\u003c\/p\u003e\n\u003cul data-path-to-node=\"22\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"22,0,0\"\u003e\u003cb data-path-to-node=\"22,0,0\" data-index-in-node=\"0\"\u003eRas-MAPK\/ERK Pathway:\u003c\/b\u003e Drives the transcription of immediate-early genes like \u003ci data-path-to-node=\"22,0,0\" data-index-in-node=\"77\"\u003eArc\u003c\/i\u003e and \u003ci data-path-to-node=\"22,0,0\" data-index-in-node=\"85\"\u003ec-Fos\u003c\/i\u003e, which are indispensable for cytoskeletal reorganization.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"22,1,0\"\u003e\u003cb data-path-to-node=\"22,1,0\" data-index-in-node=\"0\"\u003ePI3K-Akt-mTOR Pathway:\u003c\/b\u003e Promotes cell survival by inhibiting apoptotic factors (BAD) and regulating protein translation for dendritic spine growth.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"22,2,0\"\u003e\u003cb data-path-to-node=\"22,2,0\" data-index-in-node=\"0\"\u003ePLC-γ Pathway:\u003c\/b\u003e Mobilizes intracellular Calcium to activate CaMKII, synergizing with MAPK to regulate synaptic strength.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003chr data-path-to-node=\"23\"\u003e\n\u003ch3 data-path-to-node=\"24\"\u003e\u003cb data-path-to-node=\"24\" data-index-in-node=\"0\"\u003eKey Research Applications\u003c\/b\u003e\u003c\/h3\u003e\n\u003ch4 data-path-to-node=\"25\"\u003e\u003cb data-path-to-node=\"25\" data-index-in-node=\"0\"\u003e1. Synaptic Plasticity \u0026amp; Memory (LTP)\u003c\/b\u003e\u003c\/h4\u003e\n\u003cp data-path-to-node=\"26\"\u003eBDNF is the critical mediator of Late-Phase Long-Term Potentiation (L-LTP).\u003c\/p\u003e\n\u003cul data-path-to-node=\"27\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"27,0,0\"\u003e\u003cb data-path-to-node=\"27,0,0\" data-index-in-node=\"0\"\u003eElectrophysiology:\u003c\/b\u003e Research in hippocampal slices demonstrates that BDNF infusion enhances the field excitatory postsynaptic potential (fEPSP) slope by over \u003cb data-path-to-node=\"27,0,0\" data-index-in-node=\"157\"\u003e60%\u003c\/b\u003e, significantly facilitating memory consolidation.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"27,1,0\"\u003e\u003cb data-path-to-node=\"27,1,0\" data-index-in-node=\"0\"\u003eDendritic Morphology:\u003c\/b\u003e Treatment shifts dendritic spines toward a mature \"mushroom\" phenotype, increasing spine density in the CA1 region.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch4 data-path-to-node=\"28\"\u003e\u003cb data-path-to-node=\"28\" data-index-in-node=\"0\"\u003e2. Neurodegenerative Rescue (Alzheimer's \u0026amp; Depression)\u003c\/b\u003e\u003c\/h4\u003e\n\u003cul data-path-to-node=\"29\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"29,0,0\"\u003e\u003cb data-path-to-node=\"29,0,0\" data-index-in-node=\"0\"\u003eAlzheimer's Models:\u003c\/b\u003e In transgenic amyloid models (J20), viral delivery of BDNF to the entorhinal cortex prevented spatial memory deficits, suggesting it confers \"synaptic resilience\" against amyloid toxicity.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"29,1,0\"\u003e\u003cb data-path-to-node=\"29,1,0\" data-index-in-node=\"0\"\u003eDepression:\u003c\/b\u003e In the Forced Swim Test (FST), intrahippocampal BDNF has been shown to restore mobility in corticosterone-exposed models, mimicking the efficacy of chronic antidepressant treatment.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch4 data-path-to-node=\"30\"\u003e\u003cb data-path-to-node=\"30\" data-index-in-node=\"0\"\u003e3. Systemic Physiology (Cardiac \u0026amp; Metabolic)\u003c\/b\u003e\u003c\/h4\u003e\n\u003cp data-path-to-node=\"31\"\u003eBDNF is a potent myokine and cardiokine.\u003c\/p\u003e\n\u003cul data-path-to-node=\"32\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"32,0,0\"\u003e\u003cb data-path-to-node=\"32,0,0\" data-index-in-node=\"0\"\u003eCardiac Repair:\u003c\/b\u003e In ischemia-reperfusion models, BDNF administration reduced total infarct volume by approximately \u003cb data-path-to-node=\"32,0,0\" data-index-in-node=\"114\"\u003e47%\u003c\/b\u003e by counter-regulating apoptotic ratios.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"32,1,0\"\u003e\u003cb data-path-to-node=\"32,1,0\" data-index-in-node=\"0\"\u003eMetabolic Regulation:\u003c\/b\u003e In diabetic (db\/db) mice, systemic BDNF enhanced glucose utilization in skeletal muscle via AMPK pathways, independent of insulin.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003chr data-path-to-node=\"33\"\u003e\n\u003ch3 data-path-to-node=\"34\"\u003e\u003cb data-path-to-node=\"34\" data-index-in-node=\"0\"\u003eChemical Specifications\u003c\/b\u003e\u003c\/h3\u003e\n\u003cul data-path-to-node=\"35\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"35,0,0\"\u003e\u003cb data-path-to-node=\"35,0,0\" data-index-in-node=\"0\"\u003eMolecular Weight:\u003c\/b\u003e ~27.0 kDa (Homodimer)\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"35,1,0\"\u003e\u003cb data-path-to-node=\"35,1,0\" data-index-in-node=\"0\"\u003eStructure:\u003c\/b\u003e Cystine-knot motif with three intrachain disulfide bonds per monomer.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"35,2,0\"\u003e\u003cb data-path-to-node=\"35,2,0\" data-index-in-node=\"0\"\u003eHomology:\u003c\/b\u003e Mature human BDNF shares absolute sequence identity with murine BDNF, making this recombinant human protein fully bioactive in mouse and rat models.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003chr data-path-to-node=\"37\"\u003e\n\u003ch3 data-path-to-node=\"38\"\u003e\u003cb data-path-to-node=\"38\" data-index-in-node=\"0\"\u003eStorage \u0026amp; Handling\u003c\/b\u003e\u003c\/h3\u003e\n\u003cul data-path-to-node=\"39\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"39,0,0\"\u003e\u003cb data-path-to-node=\"39,0,0\" data-index-in-node=\"0\"\u003ePhysical State:\u003c\/b\u003e Lyophilized (Freeze-Dried) Powder.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"39,1,0\"\u003e\u003cb data-path-to-node=\"39,1,0\" data-index-in-node=\"0\"\u003eStorage (Powder):\u003c\/b\u003e Store at -20°C to -80°C. Stable for up to 2 years.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"39,2,0\"\u003e\u003cb data-path-to-node=\"39,2,0\" data-index-in-node=\"0\"\u003eReconstitution:\u003c\/b\u003e\u003c\/p\u003e\n\u003cul data-path-to-node=\"39,2,1\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"39,2,1,0,0\"\u003e\u003cb data-path-to-node=\"39,2,1,0,0\" data-index-in-node=\"0\"\u003eConcentration:\u003c\/b\u003e Reconstitute to \u003cb data-path-to-node=\"39,2,1,0,0\" data-index-in-node=\"31\"\u003eno less than 100 µg\/mL\u003c\/b\u003e (0.1 mg\/mL) to prevent adsorption to vial walls.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"39,2,1,1,0\"\u003e\u003cb data-path-to-node=\"39,2,1,1,0\" data-index-in-node=\"0\"\u003eSolvent:\u003c\/b\u003e Sterile Water or 0.4% NaHCO3.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"39,3,0\"\u003e\u003cb data-path-to-node=\"39,3,0\" data-index-in-node=\"0\"\u003eStorage (Liquid):\u003c\/b\u003e Store at 4°C for up to 1 week. For long-term, aliquot and freeze at -20°C. \u003cb data-path-to-node=\"39,3,0\" data-index-in-node=\"93\"\u003eAvoid freeze-thaw cycles.\u003c\/b\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003chr data-path-to-node=\"40\"\u003e\n\u003ch3 data-path-to-node=\"41\"\u003e\u003cb data-path-to-node=\"41\" data-index-in-node=\"0\"\u003eDisclaimer\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp data-path-to-node=\"42\"\u003e\u003cb data-path-to-node=\"42\" data-index-in-node=\"0\"\u003eFOR RESEARCH USE ONLY.\u003c\/b\u003e This product is a chemical compound intended strictly for laboratory research and development. It is not approved by the FDA for clinical use, diagnostics, or therapeutic procedures in humans or animals. The physiological and toxicological properties of this chemical have not been fully investigated.\u003c\/p\u003e","brand":"Peptagon","offers":[{"title":"Default Title","offer_id":47709778706646,"sku":"BDNF-10","price":124.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0783\/3085\/5638\/files\/BDNF-10mgm.png?v=1768510121","url":"https:\/\/peptagon.com\/products\/bdnf-recombinant-brain-derived-neurotrophic-factor","provider":"Peptagon","version":"1.0","type":"link"}