{"product_id":"cardiogen-ala-glu-asp-arg-research-peptide","title":"Cardiogen Research Peptide – 25mg","description":"\u003ch4 data-path-to-node=\"13\"\u003e\u003cstrong\u003eCardiogen Peptide (Lyophilized)\u003c\/strong\u003e\u003c\/h4\u003e\n\u003cp data-path-to-node=\"14\"\u003e\u003cb data-path-to-node=\"14\" data-index-in-node=\"0\"\u003eSequence:\u003c\/b\u003e Ala-Glu-Asp-Arg (AEDR) \u003cb data-path-to-node=\"14\" data-index-in-node=\"33\"\u003eFormat:\u003c\/b\u003e Sterile Lyophilized Powder (Vial) \u003cb data-path-to-node=\"14\" data-index-in-node=\"75\"\u003eClass:\u003c\/b\u003e Synthetic Peptide Bioregulator (Cytogen) \u003cb data-path-to-node=\"14\" data-index-in-node=\"123\"\u003ePurity:\u003c\/b\u003e \u0026gt;98% (HPLC) \u003cb data-path-to-node=\"14\" data-index-in-node=\"143\"\u003eContent:\u003c\/b\u003e 20mg per vial\u003c\/p\u003e\n\u003chr data-path-to-node=\"15\"\u003e\n\u003ch3 data-path-to-node=\"16\"\u003e\u003cb data-path-to-node=\"16\" data-index-in-node=\"0\"\u003eProduct Overview\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp data-path-to-node=\"17\"\u003e\u003cb data-path-to-node=\"17\" data-index-in-node=\"0\"\u003eCardiogen\u003c\/b\u003e is a synthetic tetrapeptide (Ala-Glu-Asp-Arg) developed based on the amino acid analysis of cardiac tissue extracts. It belongs to the class of \"Cytogens\"—short-chain bioregulators designed to mimic endogenous signaling molecules that govern tissue repair and homeostasis.\u003c\/p\u003e\n\u003cp data-path-to-node=\"18\"\u003eUnlike standard cardiovascular pharmaceuticals that block receptors (e.g., Beta-blockers) or inhibit enzymes (e.g., ACE inhibitors), Cardiogen is posited to function as an \u003cb data-path-to-node=\"18\" data-index-in-node=\"172\"\u003eepigenetic modulator\u003c\/b\u003e. Research suggests it intervenes at the genomic level, initiating transcriptional programs that revitalize the protein synthetic machinery of cardiomyocytes and normalize extracellular matrix turnover. It is extensively studied for its potential in myocardial infarction recovery and the prevention of age-related cardiac decline.\u003c\/p\u003e\n\u003chr data-path-to-node=\"19\"\u003e\n\u003ch3 data-path-to-node=\"20\"\u003e\u003cb data-path-to-node=\"20\" data-index-in-node=\"0\"\u003eMechanism of Action: Epigenetic Regulation\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp data-path-to-node=\"21\"\u003eCardiogen functions according to the \"Peptide-DNA Interaction Theory.\" Its specific charge profile (Acidic Core\/Basic Terminus) allows it to enter the nucleus and bind directly to the major groove of DNA in GC-rich promoter regions.\u003c\/p\u003e\n\u003cul data-path-to-node=\"22\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"22,0,0\"\u003e\u003cb data-path-to-node=\"22,0,0\" data-index-in-node=\"0\"\u003eChromatin Decondensation:\u003c\/b\u003e Binding induces the \"unwinding\" (deheterochromatinization) of silenced chromatin, making genes accessible to transcription factors.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"22,1,0\"\u003e\u003cb data-path-to-node=\"22,1,0\" data-index-in-node=\"0\"\u003eTranscriptional Targets:\u003c\/b\u003e\u003c\/p\u003e\n\u003cul data-path-to-node=\"22,1,1\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"22,1,1,0,0\"\u003e\u003cb data-path-to-node=\"22,1,1,0,0\" data-index-in-node=\"0\"\u003eUpregulation:\u003c\/b\u003e Stimulates expression of proliferation markers (\u003cb data-path-to-node=\"22,1,1,0,0\" data-index-in-node=\"62\"\u003eKi-67\u003c\/b\u003e, \u003cb data-path-to-node=\"22,1,1,0,0\" data-index-in-node=\"69\"\u003ePCNA\u003c\/b\u003e) and differentiation factors (\u003cb data-path-to-node=\"22,1,1,0,0\" data-index-in-node=\"104\"\u003eNkx2.5\u003c\/b\u003e, \u003cb data-path-to-node=\"22,1,1,0,0\" data-index-in-node=\"112\"\u003eGATA4\u003c\/b\u003e) in cardiac tissue.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"22,1,1,1,0\"\u003e\u003cb data-path-to-node=\"22,1,1,1,0\" data-index-in-node=\"0\"\u003eDownregulation:\u003c\/b\u003e Uniquely downregulates \u003cb data-path-to-node=\"22,1,1,1,0\" data-index-in-node=\"39\"\u003ep53\u003c\/b\u003e (apoptosis checkpoint) in ischemic heart tissue, promoting cell survival during stress.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003chr data-path-to-node=\"23\"\u003e\n\u003ch3 data-path-to-node=\"24\"\u003e\u003cb data-path-to-node=\"24\" data-index-in-node=\"0\"\u003eKey Research Applications\u003c\/b\u003e\u003c\/h3\u003e\n\u003ch4 data-path-to-node=\"25\"\u003e\u003cb data-path-to-node=\"25\" data-index-in-node=\"0\"\u003e1. Myocardial Infarction \u0026amp; Ischemia\u003c\/b\u003e\u003c\/h4\u003e\n\u003cp data-path-to-node=\"26\"\u003eCardiogen is investigated for its ability to reduce infarct size and mortality in rodent models of coronary artery ligation.\u003c\/p\u003e\n\u003cul data-path-to-node=\"27\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"27,0,0\"\u003e\u003cb data-path-to-node=\"27,0,0\" data-index-in-node=\"0\"\u003eMetabolic Shielding:\u003c\/b\u003e It aids in the preservation of myocardial glycogen stores and mitochondrial integrity during hypoxia.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"27,1,0\"\u003e\u003cb data-path-to-node=\"27,1,0\" data-index-in-node=\"0\"\u003eTissue Salvage:\u003c\/b\u003e By suppressing p53-mediated apoptosis specifically in the heart, it preserves the \"penumbra\" (at-risk tissue) surrounding the necrotic core.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch4 data-path-to-node=\"28\"\u003e\u003cb data-path-to-node=\"28\" data-index-in-node=\"0\"\u003e2. Fibrosis \u0026amp; Remodeling\u003c\/b\u003e\u003c\/h4\u003e\n\u003cp data-path-to-node=\"29\"\u003eHeart failure is often driven by excessive scarring (fibrosis). Cardiogen acts to restore the equilibrium between cardiomyocytes and fibroblasts.\u003c\/p\u003e\n\u003cul data-path-to-node=\"30\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"30,0,0\"\u003e\u003cb data-path-to-node=\"30,0,0\" data-index-in-node=\"0\"\u003eFibroblast Modulation:\u003c\/b\u003e It discourages the \"myofibroblast\" phenotype, reducing excessive collagen deposition.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"30,1,0\"\u003e\u003cb data-path-to-node=\"30,1,0\" data-index-in-node=\"0\"\u003eMatrix Integrity:\u003c\/b\u003e Promotes the synthesis of physiological structural proteins (Actin, Vimentin, Lamin A\/C) rather than scar tissue, helping to maintain ventricular geometry and prevent dilation.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch4 data-path-to-node=\"31\"\u003e\u003cb data-path-to-node=\"31\" data-index-in-node=\"0\"\u003e3. Oncological Safety (The p53 Paradox)\u003c\/b\u003e\u003c\/h4\u003e\n\u003cp data-path-to-node=\"32\"\u003eA critical distinction in Cardiogen research is its context-dependent action. While it suppresses p53 in healthy heart tissue to prevent cell death, studies (Levdik \u0026amp; Knyazkin) indicate it \u003cb data-path-to-node=\"32\" data-index-in-node=\"189\"\u003einhibits\u003c\/b\u003e tumor growth (e.g., M-1 Sarcoma) by inducing hemorrhagic necrosis in tumor vasculature. This suggests a true \"bioregulatory\" function—supporting homeostasis while disrupting pathology.\u003c\/p\u003e\n\u003chr data-path-to-node=\"33\"\u003e\n\u003ch3 data-path-to-node=\"34\"\u003e\u003cb data-path-to-node=\"34\" data-index-in-node=\"0\"\u003eImportant Distinction: Cardiogen vs. Cardiogenol C\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp data-path-to-node=\"35\"\u003eResearchers must distinguish between two similarly named but chemically distinct compounds:\u003c\/p\u003e\n\u003cul data-path-to-node=\"36\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"36,0,0\"\u003e\u003cb data-path-to-node=\"36,0,0\" data-index-in-node=\"0\"\u003eCardiogen (This Product):\u003c\/b\u003e A synthetic \u003cb data-path-to-node=\"36,0,0\" data-index-in-node=\"38\"\u003etetrapeptide (Ala-Glu-Asp-Arg)\u003c\/b\u003e used for in vivo bioregulation and tissue repair.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"36,1,0\"\u003e\u003cb data-path-to-node=\"36,1,0\" data-index-in-node=\"0\"\u003eCardiogenol C:\u003c\/b\u003e A synthetic \u003cb data-path-to-node=\"36,1,0\" data-index-in-node=\"27\"\u003esmall molecule (Diaminopyrimidine)\u003c\/b\u003e used primarily in vitro to force stem cell differentiation.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"36,2,0\"\u003e\u003ci data-path-to-node=\"36,2,0\" data-index-in-node=\"0\"\u003eThis listing is for the Tetrapeptide (AEDR).\u003c\/i\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003chr data-path-to-node=\"37\"\u003e\n\u003ch3 data-path-to-node=\"38\"\u003e\u003cb data-path-to-node=\"38\" data-index-in-node=\"0\"\u003eStorage \u0026amp; Handling\u003c\/b\u003e\u003c\/h3\u003e\n\u003cul data-path-to-node=\"39\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"39,0,0\"\u003e\u003cb data-path-to-node=\"39,0,0\" data-index-in-node=\"0\"\u003ePhysical State:\u003c\/b\u003e Lyophilized (Freeze-Dried) Powder.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"39,1,0\"\u003e\u003cb data-path-to-node=\"39,1,0\" data-index-in-node=\"0\"\u003eStorage (Powder):\u003c\/b\u003e Store at -20°C (Freezer). Stable for up to 24 months.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"39,2,0\"\u003e\u003cb data-path-to-node=\"39,2,0\" data-index-in-node=\"0\"\u003eReconstitution:\u003c\/b\u003e\u003c\/p\u003e\n\u003cul data-path-to-node=\"39,2,1\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"39,2,1,0,0\"\u003e\u003cb data-path-to-node=\"39,2,1,0,0\" data-index-in-node=\"0\"\u003eSolvent:\u003c\/b\u003e Bacteriostatic Water or Sterile Saline.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"39,2,1,1,0\"\u003e\u003cb data-path-to-node=\"39,2,1,1,0\" data-index-in-node=\"0\"\u003eSolubility:\u003c\/b\u003e Hydrophilic and readily soluble.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"39,3,0\"\u003e\u003cb data-path-to-node=\"39,3,0\" data-index-in-node=\"0\"\u003eStorage (Liquid):\u003c\/b\u003e Store at 4°C (Refrigerator). Use within 14 days to prevent degradation.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003chr data-path-to-node=\"40\"\u003e\n\u003ch3 data-path-to-node=\"41\"\u003e\u003cb data-path-to-node=\"41\" data-index-in-node=\"0\"\u003eDisclaimer\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp data-path-to-node=\"42\"\u003e\u003cb data-path-to-node=\"42\" data-index-in-node=\"0\"\u003eFOR RESEARCH USE ONLY.\u003c\/b\u003e This product is a chemical compound intended strictly for laboratory research and development. It is not approved by the FDA for clinical use, diagnostics, or therapeutic procedures in humans or animals. The physiological and toxicological properties of this chemical have not been fully investigated.\u003c\/p\u003e","brand":"Peptagon","offers":[{"title":"Default Title","offer_id":47709951918294,"sku":"CARDIO-25","price":36.0,"currency_code":"USD","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0783\/3085\/5638\/files\/Cardiogen-20MG.png?v=1768510161","url":"https:\/\/peptagon.com\/products\/cardiogen-ala-glu-asp-arg-research-peptide","provider":"Peptagon","version":"1.0","type":"link"}