{"product_id":"cartalax-ala-glu-asp-research-peptide","title":"Cartalax Research Peptide – 25mg","description":"\u003ch4 data-path-to-node=\"13\"\u003e\u003cstrong\u003eCartalax Peptide (Lyophilized)\u003c\/strong\u003e\u003c\/h4\u003e\n\u003cp data-path-to-node=\"14\"\u003e\u003cb data-path-to-node=\"14\" data-index-in-node=\"0\"\u003eSequence:\u003c\/b\u003e Ala-Glu-Asp (AED) \u003cb data-path-to-node=\"14\" data-index-in-node=\"28\"\u003eFormat:\u003c\/b\u003e Sterile Lyophilized Powder (Vial) \u003cb data-path-to-node=\"14\" data-index-in-node=\"70\"\u003eClass:\u003c\/b\u003e Synthetic Peptide Bioregulator (Cytogen AC-4) \u003cb data-path-to-node=\"14\" data-index-in-node=\"123\"\u003ePurity:\u003c\/b\u003e \u0026gt;98% (HPLC) \u003cb data-path-to-node=\"14\" data-index-in-node=\"143\"\u003eContent:\u003c\/b\u003e 25mg per vial\u003c\/p\u003e\n\u003chr data-path-to-node=\"15\"\u003e\n\u003ch3 data-path-to-node=\"16\"\u003e\u003cb data-path-to-node=\"16\" data-index-in-node=\"0\"\u003eProduct Overview\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp data-path-to-node=\"17\"\u003e\u003cb data-path-to-node=\"17\" data-index-in-node=\"0\"\u003eCartalax\u003c\/b\u003e (also designated as \u003cb data-path-to-node=\"17\" data-index-in-node=\"29\"\u003eT-31\u003c\/b\u003e or \u003cb data-path-to-node=\"17\" data-index-in-node=\"37\"\u003eAC-4\u003c\/b\u003e) is a synthetic tripeptide (L-Alanyl-L-Glutamyl-L-Aspartic acid) designed to mimic specific peptide fragments found in young, healthy cartilage. It belongs to the \"Khavinson Peptide\" family of bioregulators.\u003c\/p\u003e\n\u003cp data-path-to-node=\"18\"\u003eUnlike traditional growth factors that act on cell surface receptors, Cartalax functions as an \u003cb data-path-to-node=\"18\" data-index-in-node=\"95\"\u003eepigenetic switch\u003c\/b\u003e. It is engineered to penetrate the nuclei of chondrocytes and fibroblasts, interacting directly with chromatin to reactivate the gene expression programs associated with tissue repair. It is the primary subject of research for reversing connective tissue senescence, treating osteoarthritis, and functionalizing scaffolds for tissue engineering.\u003c\/p\u003e\n\u003cp data-path-to-node=\"19\"\u003e\u003ci data-path-to-node=\"19\" data-index-in-node=\"0\"\u003eNote: Do not confuse AC-4 (Cartalax\/Cartilage) with AC-2 (Vesugen\/Vascular).\u003c\/i\u003e\u003c\/p\u003e\n\u003chr data-path-to-node=\"20\"\u003e\n\u003ch3 data-path-to-node=\"21\"\u003e\u003cb data-path-to-node=\"21\" data-index-in-node=\"0\"\u003eMechanism of Action: Epigenetic Remodeling\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp data-path-to-node=\"22\"\u003eCartalax operates via the \"Sequence-Specific DNA Binding Model.\" Its nanoscale size allow it to pass through nuclear pores and bind to the major groove of DNA.\u003c\/p\u003e\n\u003cul data-path-to-node=\"23\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"23,0,0\"\u003e\u003cb data-path-to-node=\"23,0,0\" data-index-in-node=\"0\"\u003eChromatin Relaxation:\u003c\/b\u003e The peptide reduces the electrostatic attraction between histones and DNA. This converts silenced Heterochromatin into active Euchromatin, allowing repair genes to be transcribed.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"23,1,0\"\u003e\u003cb data-path-to-node=\"23,1,0\" data-index-in-node=\"0\"\u003eTarget Gene Activation:\u003c\/b\u003e\u003c\/p\u003e\n\u003cul data-path-to-node=\"23,1,1\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"23,1,1,0,0\"\u003e\u003cb data-path-to-node=\"23,1,1,0,0\" data-index-in-node=\"0\"\u003eCOL11A1 Upregulation:\u003c\/b\u003e It specifically acts as a \"matrikine,\" mimicking Type XI collagen breakdown to signal the synthesis of new Type XI collagen (critical for nucleating Type II fibrils).\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"23,1,1,1,0\"\u003e\u003cb data-path-to-node=\"23,1,1,1,0\" data-index-in-node=\"0\"\u003eProliferation:\u003c\/b\u003e Significantly increases \u003cb data-path-to-node=\"23,1,1,1,0\" data-index-in-node=\"39\"\u003eKi-67\u003c\/b\u003e expression, signaling senescent cells to re-enter the cell cycle.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"23,1,1,2,0\"\u003e\u003cb data-path-to-node=\"23,1,1,2,0\" data-index-in-node=\"0\"\u003eAnti-Apoptotic:\u003c\/b\u003e Downregulates \u003cb data-path-to-node=\"23,1,1,2,0\" data-index-in-node=\"30\"\u003ep53\u003c\/b\u003e and \u003cb data-path-to-node=\"23,1,1,2,0\" data-index-in-node=\"38\"\u003eCaspase-3\u003c\/b\u003e, preventing cell death in aging tissues.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003chr data-path-to-node=\"24\"\u003e\n\u003ch3 data-path-to-node=\"25\"\u003e\u003cb data-path-to-node=\"25\" data-index-in-node=\"0\"\u003eKey Research Applications\u003c\/b\u003e\u003c\/h3\u003e\n\u003ch4 data-path-to-node=\"26\"\u003e\u003cb data-path-to-node=\"26\" data-index-in-node=\"0\"\u003e1. Osteoarthritis \u0026amp; Cartilage Repair\u003c\/b\u003e\u003c\/h4\u003e\n\u003cp data-path-to-node=\"27\"\u003eIn organotypic tissue cultures (explants), Cartalax has been shown to increase the \"Area Index\" (migration and growth of cells) by \u003cb data-path-to-node=\"27\" data-index-in-node=\"131\"\u003e30-40%\u003c\/b\u003e.\u003c\/p\u003e\n\u003cul data-path-to-node=\"28\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"28,0,0\"\u003e\u003cb data-path-to-node=\"28,0,0\" data-index-in-node=\"0\"\u003eSenescence Reversal:\u003c\/b\u003e It targets the \"senescence-associated secretory phenotype\" (SASP), shifting chondrocytes from a catabolic state to an anabolic state.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"28,1,0\"\u003e\u003cb data-path-to-node=\"28,1,0\" data-index-in-node=\"0\"\u003eMatrix Architecture:\u003c\/b\u003e By promoting Type XI collagen, it ensures the proper structural organization of the cartilage matrix, distinct from generic collagen boosters.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch4 data-path-to-node=\"29\"\u003e\u003cb data-path-to-node=\"29\" data-index-in-node=\"0\"\u003e2. Osteoporosis \u0026amp; Bone Density\u003c\/b\u003e\u003c\/h4\u003e\n\u003cp data-path-to-node=\"30\"\u003eResearch in ovariectomized rat models indicates that Cartalax mitigates the loss of Bone Mineral Density (BMD). The Ala-Glu-Asp sequence appears to influence osteoblasts via mechanisms similar to those in chondrocytes, supporting mineralization.\u003c\/p\u003e\n\u003ch4 data-path-to-node=\"31\"\u003e\u003cb data-path-to-node=\"31\" data-index-in-node=\"0\"\u003e3. Tissue Engineering (Scaffolds)\u003c\/b\u003e\u003c\/h4\u003e\n\u003cp data-path-to-node=\"32\"\u003eCartalax is utilized in bio-material research to functionalize hydrogels. By chemically tethering the peptide to scaffolds (e.g., chitosan or PEG), researchers can create \"bioactive\" implants that drive stem cell differentiation toward the chondrogenic lineage.\u003c\/p\u003e\n\u003chr data-path-to-node=\"33\"\u003e\n\u003ch3 data-path-to-node=\"34\"\u003e\u003cb data-path-to-node=\"34\" data-index-in-node=\"0\"\u003eStorage \u0026amp; Handling\u003c\/b\u003e\u003c\/h3\u003e\n\u003cul data-path-to-node=\"35\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"35,0,0\"\u003e\u003cb data-path-to-node=\"35,0,0\" data-index-in-node=\"0\"\u003ePhysical State:\u003c\/b\u003e Lyophilized (Freeze-Dried) Powder.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"35,1,0\"\u003e\u003cb data-path-to-node=\"35,1,0\" data-index-in-node=\"0\"\u003eStorage (Powder):\u003c\/b\u003e Store at -20°C (Freezer). Stable for up to 24 months.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"35,2,0\"\u003e\u003cb data-path-to-node=\"35,2,0\" data-index-in-node=\"0\"\u003eReconstitution:\u003c\/b\u003e\u003c\/p\u003e\n\u003cul data-path-to-node=\"35,2,1\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"35,2,1,0,0\"\u003e\u003cb data-path-to-node=\"35,2,1,0,0\" data-index-in-node=\"0\"\u003eSolvent:\u003c\/b\u003e Bacteriostatic Water or Sterile PBS.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"35,2,1,1,0\"\u003e\u003cb data-path-to-node=\"35,2,1,1,0\" data-index-in-node=\"0\"\u003eSolubility:\u003c\/b\u003e Highly soluble due to acidic residues.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"35,3,0\"\u003e\u003cb data-path-to-node=\"35,3,0\" data-index-in-node=\"0\"\u003eStorage (Liquid):\u003c\/b\u003e Store at 4°C (Refrigerator). Use within 14 days or aliquot and freeze to avoid degradation.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003chr data-path-to-node=\"36\"\u003e\n\u003ch3 data-path-to-node=\"37\"\u003e\u003cb data-path-to-node=\"37\" data-index-in-node=\"0\"\u003eDisclaimer\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp data-path-to-node=\"38\"\u003e\u003cb data-path-to-node=\"38\" data-index-in-node=\"0\"\u003eFOR RESEARCH USE ONLY.\u003c\/b\u003e This product is a chemical compound intended strictly for laboratory research and development. It is not approved by the FDA for clinical use, diagnostics, or therapeutic procedures in humans or animals. The physiological and toxicological properties of this chemical have not been fully investigated.\u003c\/p\u003e","brand":"Peptagon","offers":[{"title":"Default Title","offer_id":47709952147670,"sku":"CARTA-25","price":41.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0783\/3085\/5638\/files\/Cartalax-25mg.png?v=1768507488","url":"https:\/\/peptagon.com\/products\/cartalax-ala-glu-asp-research-peptide","provider":"Peptagon","version":"1.0","type":"link"}