{"product_id":"cjc-1295-no-dac-modified-grf-1-29-research-peptide","title":"CJC-1295 No DAC Research Peptide – 10mg","description":"\u003ch4 data-path-to-node=\"13\"\u003e\u003cstrong\u003eCJC-1295 No DAC (Modified GRF 1-29) Peptide\u003c\/strong\u003e\u003c\/h4\u003e\n\u003cp data-path-to-node=\"14\"\u003e\u003cb data-path-to-node=\"14\" data-index-in-node=\"0\"\u003eSequence:\u003c\/b\u003e Tyr-D-Ala-Asp-Ala-Ile-Phe-Thr-Gln-Ser-Tyr-Arg-Lys-Val-Leu-Ala-Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Leu-Ser-Arg-NH2 \u003cb data-path-to-node=\"14\" data-index-in-node=\"132\"\u003eFormat:\u003c\/b\u003e Sterile Lyophilized Powder (Vial) \u003cb data-path-to-node=\"14\" data-index-in-node=\"174\"\u003eClass:\u003c\/b\u003e Tetrasubstituted GHRH Analogue \u003cb data-path-to-node=\"14\" data-index-in-node=\"212\"\u003eHalf-Life:\u003c\/b\u003e ~30 Minutes (Pulsatile) \u003cb data-path-to-node=\"14\" data-index-in-node=\"247\"\u003ePurity:\u003c\/b\u003e \u0026gt;99% (HPLC) \u003cb data-path-to-node=\"14\" data-index-in-node=\"267\"\u003eContent:\u003c\/b\u003e Available in 5mg and 10mg vials\u003c\/p\u003e\n\u003chr data-path-to-node=\"15\"\u003e\n\u003ch3 data-path-to-node=\"16\"\u003e\u003cb data-path-to-node=\"16\" data-index-in-node=\"0\"\u003eProduct Overview\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp data-path-to-node=\"17\"\u003e\u003cb data-path-to-node=\"17\" data-index-in-node=\"0\"\u003eCJC-1295 No DAC\u003c\/b\u003e, scientifically known as \u003cb data-path-to-node=\"17\" data-index-in-node=\"41\"\u003eModified GRF 1-29\u003c\/b\u003e, is a rational engineering triumph in neuroendocrinology. It is a synthetic, tetrasubstituted analogue of the native Growth Hormone-Releasing Hormone (GHRH) 1-29 fragment.\u003c\/p\u003e\n\u003cp data-path-to-node=\"18\"\u003eUnlike native GHRH, which is degraded within minutes, Modified GRF 1-29 incorporates four specific amino acid substitutions that render it resistant to enzymatic cleavage (DPP-IV) and chemical oxidation. This extends its biological half-life to approximately \u003cb data-path-to-node=\"18\" data-index-in-node=\"259\"\u003e30 minutes\u003c\/b\u003e. Crucially, because it lacks the Drug Affinity Complex (DAC), it preserves the \u003cb data-path-to-node=\"18\" data-index-in-node=\"349\"\u003enatural, pulsatile secretion\u003c\/b\u003e of Growth Hormone, avoiding the \"GH bleed\" and receptor desensitization associated with continuous long-acting analogs.\u003c\/p\u003e\n\u003chr data-path-to-node=\"19\"\u003e\n\u003ch3 data-path-to-node=\"20\"\u003e\u003cb data-path-to-node=\"20\" data-index-in-node=\"0\"\u003eMechanism of Action: The Pulsatile Signal\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp data-path-to-node=\"21\"\u003eModified GRF 1-29 acts as a selective agonist for the GHRH Receptor (GHRH-R) on pituitary somatotrophs.\u003c\/p\u003e\n\u003cul data-path-to-node=\"22\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"22,0,0\"\u003e\u003cb data-path-to-node=\"22,0,0\" data-index-in-node=\"0\"\u003ecAMP-PKA Pathway:\u003c\/b\u003e Binding triggers the Gs-protein cascade, increasing intracellular cAMP. This initiates both immediate vesicle release (secretion) and long-term gene transcription (synthesis via Pit-1).\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"22,1,0\"\u003e\u003cb data-path-to-node=\"22,1,0\" data-index-in-node=\"0\"\u003eDPP-IV Resistance:\u003c\/b\u003e The substitution of \u003cb data-path-to-node=\"22,1,0\" data-index-in-node=\"39\"\u003eD-Alanine\u003c\/b\u003e at position 2 prevents the enzyme DPP-IV from cleaving the peptide, ensuring sustained receptor activation compared to native Sermorelin.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"22,2,0\"\u003e\u003cb data-path-to-node=\"22,2,0\" data-index-in-node=\"0\"\u003eSynergy:\u003c\/b\u003e It effectively \"loads the gun\" (synthesis), making it highly synergistic with Ghrelin mimetics (GHRPs) that \"pull the trigger\" (release).\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003chr data-path-to-node=\"23\"\u003e\n\u003ch3 data-path-to-node=\"24\"\u003e\u003cb data-path-to-node=\"24\" data-index-in-node=\"0\"\u003eChemical Engineering: The 4 Modifications\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp data-path-to-node=\"25\"\u003eThe \"Modified\" designation refers to four specific changes to the native sequence that optimize stability for research use:\u003c\/p\u003e\n\u003col start=\"1\" data-path-to-node=\"26\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"26,0,0\"\u003e\u003cb data-path-to-node=\"26,0,0\" data-index-in-node=\"0\"\u003eTyr1-D-Ala2:\u003c\/b\u003e Confers resistance to DPP-IV digestion.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"26,1,0\"\u003e\u003cb data-path-to-node=\"26,1,0\" data-index-in-node=\"0\"\u003eGln8:\u003c\/b\u003e Replaces Asparagine to prevent deamidation and improve shelf-stability.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"26,2,0\"\u003e\u003cb data-path-to-node=\"26,2,0\" data-index-in-node=\"0\"\u003eAla15:\u003c\/b\u003e Replaces Glycine to stabilize the alpha-helical structure for better receptor binding.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"26,3,0\"\u003e\u003cb data-path-to-node=\"26,3,0\" data-index-in-node=\"0\"\u003eLeu27:\u003c\/b\u003e Replaces Methionine to prevent oxidation (sulfoxide formation) during storage.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ol\u003e\n\u003chr data-path-to-node=\"27\"\u003e\n\u003ch3 data-path-to-node=\"28\"\u003e\u003cb data-path-to-node=\"28\" data-index-in-node=\"0\"\u003eKey Research Applications\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp data-path-to-node=\"29\"\u003e\u003cb data-path-to-node=\"29\" data-index-in-node=\"0\"\u003e1. Pulsatile GH Secretion\u003c\/b\u003e Research confirms that Modified GRF 1-29 amplifies the natural peaks of GH secretion without elevating the basal \"trough\" levels. This mimics youthful physiology and allows for receptor resensitization between pulses.\u003c\/p\u003e\n\u003cp data-path-to-node=\"30\"\u003e\u003cb data-path-to-node=\"30\" data-index-in-node=\"0\"\u003e2. Sleep Architecture (SWS)\u003c\/b\u003e GHRH is a potent somnogenic factor. Studies utilizing EEG monitoring indicate that administration prior to the sleep window enhances \u003cb data-path-to-node=\"30\" data-index-in-node=\"161\"\u003eSlow Wave Sleep (SWS)\u003c\/b\u003e and Delta wave power, which correlates with improved cognitive recovery and endogenous hormonal repair.\u003c\/p\u003e\n\u003cp data-path-to-node=\"31\"\u003e\u003cb data-path-to-node=\"31\" data-index-in-node=\"0\"\u003e3. Lipolysis (Fat Loss)\u003c\/b\u003e Through the pulsatile elevation of GH, Modified GRF 1-29 activates \u003cb data-path-to-node=\"31\" data-index-in-node=\"91\"\u003eHormone Sensitive Lipase (HSL)\u003c\/b\u003e in adipocytes. Research shows a preference for visceral adipose tissue reduction, mediated by the downregulation of PPAR-gamma.\u003c\/p\u003e\n\u003chr data-path-to-node=\"32\"\u003e\n\u003ch3 data-path-to-node=\"33\"\u003e\u003cb data-path-to-node=\"33\" data-index-in-node=\"0\"\u003eStorage \u0026amp; Handling\u003c\/b\u003e\u003c\/h3\u003e\n\u003cul data-path-to-node=\"34\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"34,0,0\"\u003e\u003cb data-path-to-node=\"34,0,0\" data-index-in-node=\"0\"\u003ePhysical State:\u003c\/b\u003e Lyophilized (Freeze-Dried) White Powder.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"34,1,0\"\u003e\u003cb data-path-to-node=\"34,1,0\" data-index-in-node=\"0\"\u003eStorage (Lyophilized):\u003c\/b\u003e Store at -20°C (Freezer). Stable for \u0026gt;24 months.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"34,2,0\"\u003e\u003cb data-path-to-node=\"34,2,0\" data-index-in-node=\"0\"\u003eReconstitution:\u003c\/b\u003e\u003c\/p\u003e\n\u003cul data-path-to-node=\"34,2,1\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"34,2,1,0,0\"\u003e\u003cb data-path-to-node=\"34,2,1,0,0\" data-index-in-node=\"0\"\u003eSolvent:\u003c\/b\u003e Bacteriostatic Water or Sterile Saline.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"34,2,1,1,0\"\u003e\u003cb data-path-to-node=\"34,2,1,1,0\" data-index-in-node=\"0\"\u003eSolubility:\u003c\/b\u003e Highly soluble (polar\/basic profile).\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"34,3,0\"\u003e\u003cb data-path-to-node=\"34,3,0\" data-index-in-node=\"0\"\u003eStorage (Reconstituted):\u003c\/b\u003e Store at 4°C (Refrigerator). Use within 14-21 days. The Leu27 substitution significantly improves solution stability compared to native GHRH.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003chr data-path-to-node=\"35\"\u003e\n\u003ch3 data-path-to-node=\"36\"\u003e\u003cb data-path-to-node=\"36\" data-index-in-node=\"0\"\u003eDisclaimer\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp data-path-to-node=\"37\"\u003e\u003cb data-path-to-node=\"37\" data-index-in-node=\"0\"\u003eFOR RESEARCH USE ONLY.\u003c\/b\u003e This product is a chemical compound intended strictly for laboratory research and development. It is not approved by the FDA for clinical use, diagnostics, or therapeutic procedures in humans or animals. The physiological and toxicological properties of this chemical have not been fully investigated.\u003c\/p\u003e","brand":"Peptagon","offers":[{"title":"10mg","offer_id":47709956112598,"sku":"CJC-NODAC-10","price":43.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0783\/3085\/5638\/files\/CJC-1295-No-DAC-10mg.png?v=1768509497","url":"https:\/\/peptagon.com\/products\/cjc-1295-no-dac-modified-grf-1-29-research-peptide","provider":"Peptagon","version":"1.0","type":"link"}