{"product_id":"cjc-1295-with-dac-ghrh-research-peptide","title":"CJC-1295 with DAC Research Peptide – 10mg","description":"\u003ch4 data-path-to-node=\"13\"\u003e\u003cstrong\u003eCJC-1295 with DAC Peptide (Lyophilized)\u003c\/strong\u003e\u003c\/h4\u003e\n\u003cp data-path-to-node=\"14\"\u003e\u003cb data-path-to-node=\"14\" data-index-in-node=\"0\"\u003eSequence:\u003c\/b\u003e Tyr-D-Ala-Asp-Ala-Ile-Phe-Thr-Gln-Ser-Tyr-Arg-Lys-Val-Leu-Ala-Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Leu-Ser-Arg-Lys(Maleimidopropionic acid)-NH2 \u003cb data-path-to-node=\"14\" data-index-in-node=\"161\"\u003eFormat:\u003c\/b\u003e Sterile Lyophilized Powder (Vial) \u003cb data-path-to-node=\"14\" data-index-in-node=\"203\"\u003eConjugation:\u003c\/b\u003e Drug Affinity Complex (DAC) \u003cb data-path-to-node=\"14\" data-index-in-node=\"244\"\u003eHalf-Life:\u003c\/b\u003e 6 to 8 Days (Long-Acting) \u003cb data-path-to-node=\"14\" data-index-in-node=\"281\"\u003ePurity:\u003c\/b\u003e \u0026gt;99% (HPLC) \u003cb data-path-to-node=\"14\" data-index-in-node=\"301\"\u003eContent:\u003c\/b\u003e Available in 5mg and 10mg vials\u003c\/p\u003e\n\u003chr data-path-to-node=\"15\"\u003e\n\u003ch3 data-path-to-node=\"16\"\u003e\u003cb data-path-to-node=\"16\" data-index-in-node=\"0\"\u003eProduct Overview\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp data-path-to-node=\"17\"\u003e\u003cb data-path-to-node=\"17\" data-index-in-node=\"0\"\u003eCJC-1295 with DAC\u003c\/b\u003e is a long-acting, tetrasubstituted analogue of Growth Hormone-Releasing Hormone (GHRH). It is distinguished by its unique \u003cb data-path-to-node=\"17\" data-index-in-node=\"140\"\u003eDrug Affinity Complex (DAC)\u003c\/b\u003e technology, which conjugates the peptide to serum albumin in vivo.\u003c\/p\u003e\n\u003cp data-path-to-node=\"18\"\u003eThis conjugation extends the biological half-life from minutes to \u003cb data-path-to-node=\"18\" data-index-in-node=\"66\"\u003e6–8 days\u003c\/b\u003e, creating a sustained elevation of Growth Hormone (GH) and IGF-1. This contrasts with \"Modified GRF 1-29\" (No DAC), which produces short, pulsatile spikes. This formulation is the primary subject of research for protocols requiring once-weekly administration and steady-state hormone elevation.\u003c\/p\u003e\n\u003chr data-path-to-node=\"19\"\u003e\n\u003ch3 data-path-to-node=\"20\"\u003e\u003cb data-path-to-node=\"20\" data-index-in-node=\"0\"\u003eMechanism of Action: In Vivo Bioconjugation\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp data-path-to-node=\"21\"\u003eCJC-1295 utilizes a sophisticated \"Trojan Horse\" delivery system via the DAC moiety.\u003c\/p\u003e\n\u003cul data-path-to-node=\"22\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"22,0,0\"\u003e\u003cb data-path-to-node=\"22,0,0\" data-index-in-node=\"0\"\u003eMaleimide Linker:\u003c\/b\u003e The peptide contains a maleimide group at the C-terminus that reacts specifically with \u003cb data-path-to-node=\"22,0,0\" data-index-in-node=\"105\"\u003eCysteine-34\u003c\/b\u003e on circulating serum albumin.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"22,1,0\"\u003e\u003cb data-path-to-node=\"22,1,0\" data-index-in-node=\"0\"\u003eAlbumin Shielding:\u003c\/b\u003e Once bound to albumin (67 kDa), the peptide is shielded from enzymatic degradation (DPP-IV) and is too large to be filtered by the kidneys.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"22,2,0\"\u003e\u003cb data-path-to-node=\"22,2,0\" data-index-in-node=\"0\"\u003eSustained Release:\u003c\/b\u003e The albumin conjugate circulates for weeks, providing continuous stimulation to the pituitary GHRH receptors.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003chr data-path-to-node=\"23\"\u003e\n\u003ch3 data-path-to-node=\"24\"\u003e\u003cb data-path-to-node=\"24\" data-index-in-node=\"0\"\u003eKey Research Applications\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp data-path-to-node=\"25\"\u003e\u003cb data-path-to-node=\"25\" data-index-in-node=\"0\"\u003e1. Sustained GH \u0026amp; IGF-1 Elevation\u003c\/b\u003e Clinical research (Teichman et al.) demonstrated that a single injection increases mean GH levels by \u003cb data-path-to-node=\"25\" data-index-in-node=\"135\"\u003e2- to 10-fold\u003c\/b\u003e and sustains elevated IGF-1 for up to \u003cb data-path-to-node=\"25\" data-index-in-node=\"187\"\u003e28 days\u003c\/b\u003e. This makes it ideal for research into chronic anabolism and lipolysis where daily injections are not feasible.\u003c\/p\u003e\n\u003cp data-path-to-node=\"26\"\u003e\u003cb data-path-to-node=\"26\" data-index-in-node=\"0\"\u003e2. GHRH Knockout Rescue\u003c\/b\u003e In GHRH knockout models, once-weekly administration of CJC-1295 was sufficient to normalize growth and induce pituitary hyperplasia (growth of somatotroph cells), proving its potent trophic effects.\u003c\/p\u003e\n\u003cp data-path-to-node=\"27\"\u003e\u003cb data-path-to-node=\"27\" data-index-in-node=\"0\"\u003e3. Lipodystrophy \u0026amp; Metabolic Research\u003c\/b\u003e Investigated for its ability to redistribute visceral fat and improve metabolic profiles in lipodystrophy models. The continuous GH pressure drives profound lipolysis via Hormone Sensitive Lipase (HSL).\u003c\/p\u003e\n\u003chr data-path-to-node=\"28\"\u003e\n\u003ch3 data-path-to-node=\"29\"\u003e\u003cb data-path-to-node=\"29\" data-index-in-node=\"0\"\u003eImportant Distinction: DAC vs. No DAC\u003c\/b\u003e\u003c\/h3\u003e\n\u003cul data-path-to-node=\"30\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"30,0,0\"\u003e\u003cb data-path-to-node=\"30,0,0\" data-index-in-node=\"0\"\u003eCJC-1295 with DAC:\u003c\/b\u003e Half-life of \u003cb data-path-to-node=\"30,0,0\" data-index-in-node=\"32\"\u003e6-8 days\u003c\/b\u003e. Causes a \"bleed\" or continuous wave of GH. Dosed weekly.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"30,1,0\"\u003e\u003cb data-path-to-node=\"30,1,0\" data-index-in-node=\"0\"\u003eModified GRF 1-29 (No DAC):\u003c\/b\u003e Half-life of \u003cb data-path-to-node=\"30,1,0\" data-index-in-node=\"41\"\u003e30 minutes\u003c\/b\u003e. Causes distinct pulses. Dosed 3x daily.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"30,2,0\"\u003e\u003ci data-path-to-node=\"30,2,0\" data-index-in-node=\"0\"\u003eThis listing is for the DAC (Long-Acting) variant.\u003c\/i\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003chr data-path-to-node=\"31\"\u003e\n\u003ch3 data-path-to-node=\"32\"\u003e\u003cb data-path-to-node=\"32\" data-index-in-node=\"0\"\u003eStorage \u0026amp; Handling\u003c\/b\u003e\u003c\/h3\u003e\n\u003cul data-path-to-node=\"33\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"33,0,0\"\u003e\u003cb data-path-to-node=\"33,0,0\" data-index-in-node=\"0\"\u003ePhysical State:\u003c\/b\u003e Lyophilized (Freeze-Dried) White Powder.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"33,1,0\"\u003e\u003cb data-path-to-node=\"33,1,0\" data-index-in-node=\"0\"\u003eStorage (Lyophilized):\u003c\/b\u003e Store at -20°C (Freezer). Stable for \u0026gt;24 months.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"33,2,0\"\u003e\u003cb data-path-to-node=\"33,2,0\" data-index-in-node=\"0\"\u003eReconstitution:\u003c\/b\u003e\u003c\/p\u003e\n\u003cul data-path-to-node=\"33,2,1\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"33,2,1,0,0\"\u003e\u003cb data-path-to-node=\"33,2,1,0,0\" data-index-in-node=\"0\"\u003eSolvent:\u003c\/b\u003e Bacteriostatic Water or Sterile Saline.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"33,2,1,1,0\"\u003e\u003cb data-path-to-node=\"33,2,1,1,0\" data-index-in-node=\"0\"\u003eSolubility:\u003c\/b\u003e Highly soluble.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"33,3,0\"\u003e\u003cb data-path-to-node=\"33,3,0\" data-index-in-node=\"0\"\u003eStorage (Reconstituted):\u003c\/b\u003e Store at 4°C (Refrigerator). While more stable than native GHRH, use within 14-21 days to ensure the maleimide linker remains active for conjugation.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003chr data-path-to-node=\"34\"\u003e\n\u003ch3 data-path-to-node=\"35\"\u003e\u003cb data-path-to-node=\"35\" data-index-in-node=\"0\"\u003eDisclaimer\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp data-path-to-node=\"36\"\u003e\u003cb data-path-to-node=\"36\" data-index-in-node=\"0\"\u003eFOR RESEARCH USE ONLY.\u003c\/b\u003e This product is a chemical compound intended strictly for laboratory research and development. It is not approved by the FDA for clinical use, diagnostics, or therapeutic procedures in humans or animals. The physiological and toxicological properties of this chemical have not been fully investigated.\u003c\/p\u003e","brand":"Peptagon","offers":[{"title":"Default Title","offer_id":47710005002454,"sku":"CJC-DAC-10","price":63.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0783\/3085\/5638\/files\/CJC-1295-With-DAC-10mg.png?v=1768509489","url":"https:\/\/peptagon.com\/products\/cjc-1295-with-dac-ghrh-research-peptide","provider":"Peptagon","version":"1.0","type":"link"}