{"product_id":"curcumin-natural-polyphenol-research-reagent","title":"Curcumin Research Reagent – 600mg","description":"\u003ch4 data-path-to-node=\"13\"\u003e\u003cstrong\u003eCurcumin Research Reagent (Crystalline)\u003c\/strong\u003e\u003c\/h4\u003e\n\u003cp data-path-to-node=\"14\"\u003e\u003cb data-index-in-node=\"0\" data-path-to-node=\"14\"\u003eIUPAC Name:\u003c\/b\u003e (1E,6E)-1,7-bis(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione \u003cb data-index-in-node=\"80\" data-path-to-node=\"14\"\u003eFormat:\u003c\/b\u003e Crystalline Yellow-Orange Powder \u003cb data-index-in-node=\"121\" data-path-to-node=\"14\"\u003eClass:\u003c\/b\u003e Polyphenol (Diarylheptanoid) \u003cb data-index-in-node=\"157\" data-path-to-node=\"14\"\u003ePurity:\u003c\/b\u003e \u0026gt;98% (HPLC) \u003cb data-index-in-node=\"177\" data-path-to-node=\"14\"\u003eContent:\u003c\/b\u003e 600mg per jar \u003cb data-index-in-node=\"200\" data-path-to-node=\"14\"\u003eSolubility:\u003c\/b\u003e DMSO, Ethanol (Practically insoluble in water)\u003cbr\u003e\u003c\/p\u003e\n\u003chr data-path-to-node=\"16\"\u003e\n\u003ch3 data-path-to-node=\"17\"\u003e\u003cb data-index-in-node=\"0\" data-path-to-node=\"17\"\u003eProduct Overview\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp data-path-to-node=\"18\"\u003e\u003cb data-index-in-node=\"0\" data-path-to-node=\"18\"\u003eCurcumin\u003c\/b\u003e is the principal bioactive curcuminoid isolated from \u003ci data-index-in-node=\"62\" data-path-to-node=\"18\"\u003eCurcuma longa\u003c\/i\u003e. Unlike the peptides found in our catalog, Curcumin is a \u003cb data-index-in-node=\"133\" data-path-to-node=\"18\"\u003ehydrophobic polyphenol\u003c\/b\u003e characterized by its pleiotropic ability to modulate multiple cell signaling pathways simultaneously.\u003c\/p\u003e\n\u003cp data-path-to-node=\"19\"\u003eThis \u003cb data-index-in-node=\"5\" data-path-to-node=\"19\"\u003e600mg Research-Grade\u003c\/b\u003e formulation is scaled to accommodate the molecule's specific pharmacokinetic profile. Due to extensive first-pass metabolism and low systemic bioavailability, high-concentration research protocols are often required to achieve pharmacologically relevant serum levels for \u003ci data-index-in-node=\"297\" data-path-to-node=\"19\"\u003ein vitro\u003c\/i\u003e and \u003ci data-index-in-node=\"310\" data-path-to-node=\"19\"\u003ein vivo\u003c\/i\u003e investigation. It is a potent probe for dissecting inflammatory cascades, amyloid pathology, and oncological signaling.\u003c\/p\u003e\n\u003chr data-path-to-node=\"20\"\u003e\n\u003ch3 data-path-to-node=\"21\"\u003e\u003cb data-index-in-node=\"0\" data-path-to-node=\"21\"\u003eMechanism of Action: The Master Switch\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp data-path-to-node=\"22\"\u003eCurcumin acts as a broad-spectrum modulator of the inflammatory genome, intercepting pathogenic signals at the transcriptional level.\u003c\/p\u003e\n\u003cul data-path-to-node=\"23\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"23,0,0\"\u003e\u003cb data-index-in-node=\"0\" data-path-to-node=\"23,0,0\"\u003eNF-κB Suppression:\u003c\/b\u003e It directly inhibits IKKβ, preventing the phosphorylation of IκBα. This sequesters the transcription factor NF-κB in the cytoplasm, halting the production of inflammatory cytokines (TNF-α, IL-6).\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"23,1,0\"\u003e\u003cb data-index-in-node=\"0\" data-path-to-node=\"23,1,0\"\u003eDual Eicosanoid Inhibition:\u003c\/b\u003e Uniquely acts as a dual inhibitor of both \u003cb data-index-in-node=\"70\" data-path-to-node=\"23,1,0\"\u003eCOX-2\u003c\/b\u003e (prostaglandins) and \u003cb data-index-in-node=\"97\" data-path-to-node=\"23,1,0\"\u003e5-LOX\u003c\/b\u003e (leukotrienes), shutting down arachidonic acid metabolism without the gastric toxicity associated with COX-1 inhibition.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"23,2,0\"\u003e\u003cb data-index-in-node=\"0\" data-path-to-node=\"23,2,0\"\u003eAntioxidant (Nrf2):\u003c\/b\u003e Activates the Nrf2 pathway, driving the expression of cytoprotective enzymes like Heme Oxygenase-1 (HO-1) and Superoxide Dismutase (SOD).\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003chr data-path-to-node=\"24\"\u003e\n\u003ch3 data-path-to-node=\"25\"\u003e\u003cb data-index-in-node=\"0\" data-path-to-node=\"25\"\u003eKey Research Applications\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp data-path-to-node=\"26\"\u003e\u003cb data-index-in-node=\"0\" data-path-to-node=\"26\"\u003e1. Autoimmunity \u0026amp; Inflammation (Arthritis)\u003c\/b\u003e In Collagen-Induced Arthritis (CIA) models, Curcumin demonstrates significant anti-inflammatory activity.\u003c\/p\u003e\n\u003cul data-path-to-node=\"27\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"27,0,0\"\u003e\u003cb data-index-in-node=\"0\" data-path-to-node=\"27,0,0\"\u003eEdema Reduction:\u003c\/b\u003e High-dose protocols suppressed paw edema by ~58%, comparable to standard NSAIDs but with a delayed onset of action consistent with genomic regulation.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"27,1,0\"\u003e\u003cb data-index-in-node=\"0\" data-path-to-node=\"27,1,0\"\u003eJoint Preservation:\u003c\/b\u003e Downregulates MMP-1 and MMP-3, preventing the enzymatic degradation of cartilage architecture.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp data-path-to-node=\"28\"\u003e\u003cb data-index-in-node=\"0\" data-path-to-node=\"28\"\u003e2. Neurodegeneration (Alzheimer's \u0026amp; BDNF)\u003c\/b\u003e Curcumin is lipophilic and crosses the Blood-Brain Barrier (BBB).\u003c\/p\u003e\n\u003cul data-path-to-node=\"29\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"29,0,0\"\u003e\u003cb data-index-in-node=\"0\" data-path-to-node=\"29,0,0\"\u003eAmyloid Clearance:\u003c\/b\u003e Enhances macrophage phagocytosis of Amyloid-β plaques and inhibits fibril aggregation.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"29,1,0\"\u003e\u003cb data-index-in-node=\"0\" data-path-to-node=\"29,1,0\"\u003eBDNF Restoration:\u003c\/b\u003e In models of depression and cognitive decline, it restores brain levels of \u003cb data-index-in-node=\"93\" data-path-to-node=\"29,1,0\"\u003eBrain-Derived Neurotrophic Factor (BDNF)\u003c\/b\u003e to near-wild-type levels, promoting neuroplasticity.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp data-path-to-node=\"30\"\u003e\u003cb data-index-in-node=\"0\" data-path-to-node=\"30\"\u003e3. Oncology (Chemosensitization)\u003c\/b\u003e Investigated for its ability to reverse Multi-Drug Resistance (MDR). In colorectal and breast cancer xenografts, Curcumin potentiates the effects of chemotherapeutics (like 5-FU), significantly reducing tumor volume via apoptosis induction (Bcl-2 downregulation).\u003c\/p\u003e\n\u003chr data-path-to-node=\"31\"\u003e\n\u003ch3 data-path-to-node=\"32\"\u003e\u003cb data-index-in-node=\"0\" data-path-to-node=\"32\"\u003eHandling \u0026amp; Bioavailability\u003c\/b\u003e\u003c\/h3\u003e\n\u003cul data-path-to-node=\"33\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"33,0,0\"\u003e\u003cb data-index-in-node=\"0\" data-path-to-node=\"33,0,0\"\u003eClassification:\u003c\/b\u003e \u003cb data-index-in-node=\"16\" data-path-to-node=\"33,0,0\"\u003eNOT A PEPTIDE.\u003c\/b\u003e This is a lipophilic polyphenol.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"33,1,0\"\u003e\u003cb data-index-in-node=\"0\" data-path-to-node=\"33,1,0\"\u003eSolubility:\u003c\/b\u003e Insoluble in water. Must be solubilized in organic solvents like \u003cb data-index-in-node=\"77\" data-path-to-node=\"33,1,0\"\u003eDMSO\u003c\/b\u003e (\u0026gt;11 mg\/mL) or \u003cb data-index-in-node=\"97\" data-path-to-node=\"33,1,0\"\u003eEthanol\u003c\/b\u003e for stock solutions.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"33,2,0\"\u003e\u003cb data-index-in-node=\"0\" data-path-to-node=\"33,2,0\"\u003eBioavailability:\u003c\/b\u003e Poor systemic absorption. Research often utilizes advanced carriers (PLGA nanoparticles, liposomes, or phytosomes) or high-dose protocols (like this 600mg quantity) to overcome rapid glucuronidation.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"33,3,0\"\u003e\u003cb data-index-in-node=\"0\" data-path-to-node=\"33,3,0\"\u003eStability:\u003c\/b\u003e Light sensitive. Store in amber vials at -20°C to prevent oxidative degradation. Unstable in alkaline buffers (pH \u0026gt; 7).\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003chr data-path-to-node=\"34\"\u003e\n\u003ch3 data-path-to-node=\"35\"\u003e\u003cb data-index-in-node=\"0\" data-path-to-node=\"35\"\u003eDisclaimer\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp data-path-to-node=\"36\"\u003e\u003cb data-index-in-node=\"0\" data-path-to-node=\"36\"\u003eFOR RESEARCH USE ONLY.\u003c\/b\u003e This product is a chemical compound intended strictly for laboratory research and development. It is not approved by the FDA for clinical use, diagnostics, or therapeutic procedures in humans or animals. The physiological and toxicological properties of this chemical have not been fully investigated.\u003c\/p\u003e","brand":"Peptagon","offers":[{"title":"Default Title","offer_id":47710005067990,"sku":"CURCUMIN-600","price":132.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0783\/3085\/5638\/files\/Curcumin-600mg_ae839c76-d94c-4ed2-813d-2a770b8b2ba9.png?v=1768510191","url":"https:\/\/peptagon.com\/products\/curcumin-natural-polyphenol-research-reagent","provider":"Peptagon","version":"1.0","type":"link"}