{"product_id":"dihexa-pnb-0408-hgf-c-met-research-tablets","title":"Dihexa Research Tablets – 8mg \/ 30mg – 30 Count","description":"\u003ch4 data-path-to-node=\"11\"\u003e\u003cstrong\u003eDihexa: The Synaptogenic Catalyst\u003c\/strong\u003e\u003c\/h4\u003e\n\u003cp data-path-to-node=\"12\"\u003e\u003cb data-path-to-node=\"12\" data-index-in-node=\"0\"\u003eCore Molecule:\u003c\/b\u003e N-hexanoic-tyrosine-isoleucine-(6) aminohexanoic amide \u003cb data-path-to-node=\"12\" data-index-in-node=\"70\"\u003eFormat:\u003c\/b\u003e Oral Tablets \u003cb data-path-to-node=\"12\" data-index-in-node=\"91\"\u003eClass:\u003c\/b\u003e HGF Mimetic \/ Neurorestorative Peptide \u003cb data-path-to-node=\"12\" data-index-in-node=\"137\"\u003ePurity:\u003c\/b\u003e ≥98% (HPLC) \u003cb data-path-to-node=\"12\" data-index-in-node=\"157\"\u003eTarget:\u003c\/b\u003e HGF\/c-Met Signaling Pathway\u003c\/p\u003e\n\u003chr data-path-to-node=\"13\"\u003e\n\u003ch3 data-path-to-node=\"14\"\u003e\u003cb data-path-to-node=\"14\" data-index-in-node=\"0\"\u003eProduct Overview\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp data-path-to-node=\"15\"\u003e\u003cb data-path-to-node=\"15\" data-index-in-node=\"0\"\u003eDihexa (PNB-0408)\u003c\/b\u003e is a first-in-class, orally active oligopeptide designed to repair and rebuild neural architecture. Originally developed as a stabilized analog of Angiotensin IV, Dihexa was engineered to overcome the blood-brain barrier (BBB) and provide a regenerative approach to neurological decline.\u003c\/p\u003e\n\u003cp data-path-to-node=\"16\"\u003eDihexa is widely recognized for its \"synaptogenic\" properties—the ability to create new, functional connections between neurons. Unlike traditional agents that merely manage symptoms, Dihexa targets the underlying loss of connectivity in the brain, making it a premier candidate for research into Alzheimer’s disease, Parkinson’s disease, and traumatic brain injury.\u003c\/p\u003e\n\u003chr data-path-to-node=\"17\"\u003e\n\u003ch3 data-path-to-node=\"18\"\u003e\u003cb data-path-to-node=\"18\" data-index-in-node=\"0\"\u003eMechanism of Action: Rebuilding the Neural Web\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp data-path-to-node=\"19\"\u003eDihexa operates by potentiation of the \u003cb data-path-to-node=\"19\" data-index-in-node=\"39\"\u003eHepatocyte Growth Factor (HGF)\u003c\/b\u003e and its receptor, \u003cb data-path-to-node=\"19\" data-index-in-node=\"88\"\u003ec-Met\u003c\/b\u003e.\u003c\/p\u003e\n\u003cul data-path-to-node=\"20\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"20,0,0\"\u003e\u003cb data-path-to-node=\"20,0,0\" data-index-in-node=\"0\"\u003eSynaptogenesis:\u003c\/b\u003e By allosterically modulating HGF, Dihexa triggers the \u003cb data-path-to-node=\"20,0,0\" data-index-in-node=\"70\"\u003ePI3K\/AKT\u003c\/b\u003e and \u003cb data-path-to-node=\"20,0,0\" data-index-in-node=\"83\"\u003eMAPK\/ERK\u003c\/b\u003e pathways. This initiates the formation of new dendritic spines and functional synapses.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"20,1,0\"\u003e\u003cb data-path-to-node=\"20,1,0\" data-index-in-node=\"0\"\u003eExceptional Potency:\u003c\/b\u003e In laboratory assays, Dihexa demonstrated a neurotrophic potency \u003cb data-path-to-node=\"20,1,0\" data-index-in-node=\"86\"\u003eseven orders of magnitude (10^7 times) greater than BDNF\u003c\/b\u003e (Brain-Derived Neurotrophic Factor).\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"20,2,0\"\u003e\u003cb data-path-to-node=\"20,2,0\" data-index-in-node=\"0\"\u003eStructural Maturity:\u003c\/b\u003e It promotes the development of mature \"mushroom\" spine morphologies, which are associated with stable, long-term memory storage and robust neurotransmission.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"20,3,0\"\u003e\u003cb data-path-to-node=\"20,3,0\" data-index-in-node=\"0\"\u003eNeuroprotection:\u003c\/b\u003e It reduces neuroinflammation by decreasing astrocyte and microglia activation while increasing anti-inflammatory cytokines like IL-10.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003chr data-path-to-node=\"21\"\u003e\n\u003ch3 data-path-to-node=\"22\"\u003e\u003cb data-path-to-node=\"22\" data-index-in-node=\"0\"\u003eKey Research Applications\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp data-path-to-node=\"23\"\u003e\u003cb data-path-to-node=\"23\" data-index-in-node=\"0\"\u003e1. Alzheimer’s \u0026amp; Cognitive Decline\u003c\/b\u003e Investigated for its ability to rescue cognitive function. In APP\/PS1 mouse models, Dihexa significantly improved spatial learning and learning memory, returning performance to levels indistinguishable from healthy controls.\u003c\/p\u003e\n\u003cp data-path-to-node=\"24\"\u003e\u003cb data-path-to-node=\"24\" data-index-in-node=\"0\"\u003e2. Parkinson’s \u0026amp; Motor Recovery\u003c\/b\u003e Research supported by the Michael J. Fox Foundation showed that Dihexa can completely restore motor function in preclinical models of Parkinson's by promoting the survival of dopaminergic neurons and recovering Tyrosine Hydroxylase (TH) levels.\u003c\/p\u003e\n\u003cp data-path-to-node=\"25\"\u003e\u003cb data-path-to-node=\"25\" data-index-in-node=\"0\"\u003e3. Peripheral Nerve Repair\u003c\/b\u003e Studies demonstrate that Dihexa accelerates recovery from peripheral nerve injuries (PNI), enhancing motor reinnervation and mitigating muscle atrophy following nerve transection.\u003c\/p\u003e\n\u003chr data-path-to-node=\"26\"\u003e\n\u003ch3 data-path-to-node=\"27\"\u003e\u003cb data-path-to-node=\"27\" data-index-in-node=\"0\"\u003eStorage \u0026amp; Handling\u003c\/b\u003e\u003c\/h3\u003e\n\u003cul data-path-to-node=\"28\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"28,0,0\"\u003e\u003cb data-path-to-node=\"28,0,0\" data-index-in-node=\"0\"\u003ePhysical State:\u003c\/b\u003e Tablet form for consistent oral research protocols.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"28,1,0\"\u003e\u003cb data-path-to-node=\"28,1,0\" data-index-in-node=\"0\"\u003eStorage:\u003c\/b\u003e Store in a cool, dry place.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"28,2,0\"\u003e\u003cb data-path-to-node=\"28,2,0\" data-index-in-node=\"0\"\u003eLong-Term Storage:\u003c\/b\u003e Store at -20°C (Freezer) to maintain maximum purity and resist peptidase degradation.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"28,3,0\"\u003e\u003cb data-path-to-node=\"28,3,0\" data-index-in-node=\"0\"\u003eStability:\u003c\/b\u003e Highly stable and resistant to the harsh environment of the gastrointestinal tract.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003chr data-path-to-node=\"29\"\u003e\n\u003ch3 data-path-to-node=\"30\"\u003e\u003cb data-path-to-node=\"30\" data-index-in-node=\"0\"\u003eDisclaimer\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp data-path-to-node=\"31\"\u003e\u003cb data-path-to-node=\"31\" data-index-in-node=\"0\"\u003eFOR RESEARCH USE ONLY.\u003c\/b\u003e This product is a chemical compound intended strictly for laboratory research and development. It is not approved by the FDA for clinical use, diagnostics, or therapeutic procedures in humans or animals. The physiological and toxicological properties of this chemical have not been fully investigated.\u003c\/p\u003e","brand":"Peptagon","offers":[{"title":"8mg","offer_id":48169997598934,"sku":"DIHEX-8x30","price":92.0,"currency_code":"USD","in_stock":true},{"title":"30mg","offer_id":48169997631702,"sku":null,"price":206.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0783\/3085\/5638\/files\/Dihexa-_8mg_-x-30-Tablets.png?v=1768837429","url":"https:\/\/peptagon.com\/products\/dihexa-pnb-0408-hgf-c-met-research-tablets","provider":"Peptagon","version":"1.0","type":"link"}