{"product_id":"dsip-delta-sleep-inducing-research-peptide","title":"DSIP Research Peptide – 5mg","description":"\u003ch4 data-path-to-node=\"13\"\u003e\u003cstrong\u003eDSIP (Delta Sleep-Inducing Peptide) Lyophilized\u003c\/strong\u003e\u003c\/h4\u003e\n\u003cp data-path-to-node=\"14\"\u003e\u003cb data-path-to-node=\"14\" data-index-in-node=\"0\"\u003eSequence:\u003c\/b\u003e Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu (WAGGDASGE) \u003cb data-path-to-node=\"14\" data-index-in-node=\"58\"\u003eFormat:\u003c\/b\u003e Sterile Lyophilized Powder (Vial) \u003cb data-path-to-node=\"14\" data-index-in-node=\"100\"\u003eMolecular Weight:\u003c\/b\u003e ~848.8 Da \u003cb data-path-to-node=\"14\" data-index-in-node=\"128\"\u003ePurity:\u003c\/b\u003e \u0026gt;98% (HPLC) \u003cb data-path-to-node=\"14\" data-index-in-node=\"148\"\u003eContent:\u003c\/b\u003e 5mg per vial\u003c\/p\u003e\n\u003chr data-path-to-node=\"15\"\u003e\n\u003ch3 data-path-to-node=\"16\"\u003e\u003cb data-path-to-node=\"16\" data-index-in-node=\"0\"\u003eProduct Overview\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp data-path-to-node=\"17\"\u003e\u003cb data-path-to-node=\"17\" data-index-in-node=\"0\"\u003eDSIP (Delta Sleep-Inducing Peptide)\u003c\/b\u003e is a naturally occurring nonapeptide first isolated from the cerebral venous blood of rabbits during slow-wave sleep. It is characterized by its unique ability to modulate the sleep-wake cycle and physiological stress responses.\u003c\/p\u003e\n\u003cp data-path-to-node=\"18\"\u003eUnlike conventional sedatives, DSIP does not merely induce sleep but functions as a \u003cb data-path-to-node=\"18\" data-index-in-node=\"84\"\u003ehomeostatic regulator\u003c\/b\u003e. Research indicates it tunes the sensitivity of multiple physiological axes—including the HPA axis and antioxidant systems—to promote adaptation, resilience, and the restoration of natural circadian rhythms. It is widely investigated for its potential in treating sleep deprivation, chronic stress, and age-related metabolic decline.\u003c\/p\u003e\n\u003chr data-path-to-node=\"19\"\u003e\n\u003ch3 data-path-to-node=\"20\"\u003e\u003cb data-path-to-node=\"20\" data-index-in-node=\"0\"\u003eMechanism of Action: The Homeostatic Regulator\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp data-path-to-node=\"21\"\u003eDSIP operates via a complex network of signaling pathways rather than a single receptor target.\u003c\/p\u003e\n\u003cul data-path-to-node=\"22\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"22,0,0\"\u003e\u003cb data-path-to-node=\"22,0,0\" data-index-in-node=\"0\"\u003eSleep Architecture:\u003c\/b\u003e Promotes \u003cb data-path-to-node=\"22,0,0\" data-index-in-node=\"29\"\u003eSlow-Wave Sleep (SWS)\u003c\/b\u003e and, uniquely, enhances \u003cb data-path-to-node=\"22,0,0\" data-index-in-node=\"75\"\u003eREM sleep\u003c\/b\u003e. This contrasts with many pharmacological agents that suppress REM. It is believed to interact with the Suprachiasmatic Nucleus (SCN) to reset circadian clocks.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"22,1,0\"\u003e\u003cb data-path-to-node=\"22,1,0\" data-index-in-node=\"0\"\u003eStress Modulation (HPA Axis):\u003c\/b\u003e Acts as a \"brake\" on the stress response. It reduces basal levels of ACTH and blocks Corticotropin-Releasing Factor (CRF)-induced corticosterone release, mitigating the catabolic effects of chronic stress.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"22,2,0\"\u003e\u003cb data-path-to-node=\"22,2,0\" data-index-in-node=\"0\"\u003eAntioxidant Defense:\u003c\/b\u003e Upregulates endogenous antioxidant enzymes such as \u003cb data-path-to-node=\"22,2,0\" data-index-in-node=\"72\"\u003eSuperoxide Dismutase (SOD)\u003c\/b\u003e and \u003cb data-path-to-node=\"22,2,0\" data-index-in-node=\"103\"\u003eGlutathione Peroxidase (GPx)\u003c\/b\u003e, reducing lipid peroxidation and mitochondrial stress.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003chr data-path-to-node=\"23\"\u003e\n\u003ch3 data-path-to-node=\"24\"\u003e\u003cb data-path-to-node=\"24\" data-index-in-node=\"0\"\u003eKey Research Applications\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp data-path-to-node=\"25\"\u003e\u003cb data-path-to-node=\"25\" data-index-in-node=\"0\"\u003e1. Sleep Deprivation \u0026amp; Circadian Rhythm\u003c\/b\u003e In animal models, administration of DSIP restores the \"rebound\" of Slow-Wave Sleep following sleep deprivation. Blocking endogenous DSIP with antibodies abolishes this restorative response, confirming its physiological necessity.\u003c\/p\u003e\n\u003cp data-path-to-node=\"26\"\u003e\u003cb data-path-to-node=\"26\" data-index-in-node=\"0\"\u003e2. Neuroprotection \u0026amp; Excitotoxicity\u003c\/b\u003e DSIP modulates the balance between excitation and inhibition in the brain. It blocks NMDA-mediated excitotoxicity (calcium overload) while potentiating GABAergic transmission, offering neuroprotective benefits against oxidative stress and glutamate storms.\u003c\/p\u003e\n\u003cp data-path-to-node=\"27\"\u003e\u003cb data-path-to-node=\"27\" data-index-in-node=\"0\"\u003e3. Geroprotection (Anti-Aging)\u003c\/b\u003e Long-term studies (e.g., using the \"Deltaran\" preparation) have demonstrated profound geroprotective effects. Lifespan studies in mice showed a \u003cb data-path-to-node=\"27\" data-index-in-node=\"175\"\u003e24.1% increase in maximum lifespan\u003c\/b\u003e and a \u003cb data-path-to-node=\"27\" data-index-in-node=\"216\"\u003e2.6-fold decrease in spontaneous tumor incidence\u003c\/b\u003e, attributed to enhanced genomic stability and reduced metabolic stress.\u003c\/p\u003e\n\u003cp data-path-to-node=\"28\"\u003e\u003cb data-path-to-node=\"28\" data-index-in-node=\"0\"\u003e4. Withdrawal \u0026amp; Analgesia\u003c\/b\u003e Investigated for its ability to reset homeostatic set points in addiction models, alleviating withdrawal symptoms in opiate and alcohol dependence. It also exhibits non-opioid analgesic properties, elevating pain thresholds via circadian modulation.\u003c\/p\u003e\n\u003chr data-path-to-node=\"29\"\u003e\n\u003ch3 data-path-to-node=\"30\"\u003e\u003cb data-path-to-node=\"30\" data-index-in-node=\"0\"\u003eStorage \u0026amp; Handling\u003c\/b\u003e\u003c\/h3\u003e\n\u003cul data-path-to-node=\"31\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"31,0,0\"\u003e\u003cb data-path-to-node=\"31,0,0\" data-index-in-node=\"0\"\u003ePhysical State:\u003c\/b\u003e Lyophilized (Freeze-Dried) White Powder.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"31,1,0\"\u003e\u003cb data-path-to-node=\"31,1,0\" data-index-in-node=\"0\"\u003eStorage (Powder):\u003c\/b\u003e Store at -20°C (Freezer). Stable for up to 24 months.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"31,2,0\"\u003e\u003cb data-path-to-node=\"31,2,0\" data-index-in-node=\"0\"\u003eReconstitution:\u003c\/b\u003e\u003c\/p\u003e\n\u003cul data-path-to-node=\"31,2,1\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"31,2,1,0,0\"\u003e\u003cb data-path-to-node=\"31,2,1,0,0\" data-index-in-node=\"0\"\u003eSolvent:\u003c\/b\u003e Bacteriostatic Water or Sterile Saline.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"31,2,1,1,0\"\u003e\u003cb data-path-to-node=\"31,2,1,1,0\" data-index-in-node=\"0\"\u003eSolubility:\u003c\/b\u003e Highly soluble in water.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"31,3,0\"\u003e\u003cb data-path-to-node=\"31,3,0\" data-index-in-node=\"0\"\u003eStorage (Reconstituted):\u003c\/b\u003e Store at 4°C (Refrigerator). Use within 14 days. \u003cb data-path-to-node=\"31,3,0\" data-index-in-node=\"74\"\u003eAvoid freeze-thaw cycles.\u003c\/b\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003chr data-path-to-node=\"32\"\u003e\n\u003ch3 data-path-to-node=\"33\"\u003e\u003cb data-path-to-node=\"33\" data-index-in-node=\"0\"\u003eDisclaimer\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp data-path-to-node=\"34\"\u003e\u003cb data-path-to-node=\"34\" data-index-in-node=\"0\"\u003eFOR RESEARCH USE ONLY.\u003c\/b\u003e This product is a chemical compound intended strictly for laboratory research and development. It is not approved by the FDA for clinical use, diagnostics, or therapeutic procedures in humans or animals. The physiological and toxicological properties of this chemical have not been fully investigated.\u003c\/p\u003e","brand":"Peptagon","offers":[{"title":"Default Title","offer_id":47710005100758,"sku":"DSIP-5","price":28.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0783\/3085\/5638\/files\/DSIP-5mg.png?v=1768511106","url":"https:\/\/peptagon.com\/products\/dsip-delta-sleep-inducing-research-peptide","provider":"Peptagon","version":"1.0","type":"link"}