{"product_id":"epithalon-aedg-tetrapeptide-research-peptide","title":"Epithalon Research Peptide – 10mg \/ 50mg","description":"\u003ch4 data-path-to-node=\"13\"\u003e\u003cstrong\u003eEpithalon Peptide (Lyophilized)\u003c\/strong\u003e\u003c\/h4\u003e\n\u003cp data-path-to-node=\"14\"\u003e\u003cb data-path-to-node=\"14\" data-index-in-node=\"0\"\u003eSequence:\u003c\/b\u003e Ala-Glu-Asp-Gly (AEDG) \u003cb data-path-to-node=\"14\" data-index-in-node=\"33\"\u003eFormat:\u003c\/b\u003e Sterile Lyophilized Powder (Vial) \u003cb data-path-to-node=\"14\" data-index-in-node=\"75\"\u003eClass:\u003c\/b\u003e Synthetic Peptide Bioregulator (Pineal Mimetic) \u003cb data-path-to-node=\"14\" data-index-in-node=\"130\"\u003ePurity:\u003c\/b\u003e \u0026gt;98% (HPLC) \u003cb data-path-to-node=\"14\" data-index-in-node=\"150\"\u003eContent:\u003c\/b\u003e Available in 10mg and 50mg vials\u003c\/p\u003e\n\u003chr data-path-to-node=\"15\"\u003e\n\u003ch3 data-path-to-node=\"16\"\u003e\u003cb data-path-to-node=\"16\" data-index-in-node=\"0\"\u003eProduct Overview\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp data-path-to-node=\"17\"\u003e\u003cb data-path-to-node=\"17\" data-index-in-node=\"0\"\u003eEpithalon\u003c\/b\u003e (also known as Epitalon or AEDG) is a synthetic tetrapeptide designed to mimic the biological activity of Epithalamin, a pineal gland extract. It is a foundational compound in the field of \"bioregulator\" peptides.\u003c\/p\u003e\n\u003cp data-path-to-node=\"18\"\u003eUnlike its naturally derived precursor, Epithalon is a single, precise molecular entity (Ala-Glu-Asp-Gly). Its primary research significance lies in its capacity to activate the enzyme \u003cb data-path-to-node=\"18\" data-index-in-node=\"185\"\u003etelomerase\u003c\/b\u003e (specifically the catalytic subunit hTERT) and modulate chromatin structure. It is extensively studied for its potential to extend replicative lifespan, regulate circadian rhythms, and influence geroprotective gene expression.\u003c\/p\u003e\n\u003chr data-path-to-node=\"19\"\u003e\n\u003ch3 data-path-to-node=\"20\"\u003e\u003cb data-path-to-node=\"20\" data-index-in-node=\"0\"\u003eMechanism of Action: Epigenetic Telomerase Activation\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp data-path-to-node=\"21\"\u003eEpithalon functions as an epigenetic modulator, interacting directly with the genome rather than cell surface receptors.\u003c\/p\u003e\n\u003cul data-path-to-node=\"22\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"22,0,0\"\u003e\u003cb data-path-to-node=\"22,0,0\" data-index-in-node=\"0\"\u003eChromatin Decondensation:\u003c\/b\u003e It binds to specific histone proteins (H1\/3, H1\/6), relaxing condensed chromatin (heterochromatin). This \"unlocks\" silenced genes associated with protein synthesis and cellular repair.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"22,1,0\"\u003e\u003cb data-path-to-node=\"22,1,0\" data-index-in-node=\"0\"\u003eTelomerase Upregulation:\u003c\/b\u003e By reactivating the \u003ci data-path-to-node=\"22,1,0\" data-index-in-node=\"45\"\u003ehTERT\u003c\/i\u003e gene, Epithalon induces telomere elongation. In human fibroblast cultures, this has been shown to extend the \"Hayflick limit\" (the number of times a cell can divide) by over 10 passages.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"22,2,0\"\u003e\u003cb data-path-to-node=\"22,2,0\" data-index-in-node=\"0\"\u003eGene Regulation:\u003c\/b\u003e Downregulates senescence markers like \u003cb data-path-to-node=\"22,2,0\" data-index-in-node=\"55\"\u003ep16 (INK4a)\u003c\/b\u003e and \u003cb data-path-to-node=\"22,2,0\" data-index-in-node=\"71\"\u003ep21 (Waf1)\u003c\/b\u003e, delaying cellular aging.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003chr data-path-to-node=\"23\"\u003e\n\u003ch3 data-path-to-node=\"24\"\u003e\u003cb data-path-to-node=\"24\" data-index-in-node=\"0\"\u003eKey Research Applications\u003c\/b\u003e\u003c\/h3\u003e\n\u003ch4 data-path-to-node=\"25\"\u003e\u003cb data-path-to-node=\"25\" data-index-in-node=\"0\"\u003e1. Longevity \u0026amp; Geroprotection\u003c\/b\u003e\u003c\/h4\u003e\n\u003cp data-path-to-node=\"26\"\u003eLongitudinal studies (Khavinson et al.) in rodents have demonstrated that Epithalon can increase maximum lifespan by \u003cb data-path-to-node=\"26\" data-index-in-node=\"117\"\u003e11-25%\u003c\/b\u003e.\u003c\/p\u003e\n\u003cul data-path-to-node=\"27\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"27,0,0\"\u003e\u003cb data-path-to-node=\"27,0,0\" data-index-in-node=\"0\"\u003eMortality Reduction:\u003c\/b\u003e In long-term human observations (15 years), pineal peptide preparations were associated with a significant reduction in all-cause mortality.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"27,1,0\"\u003e\u003cb data-path-to-node=\"27,1,0\" data-index-in-node=\"0\"\u003eCircadian Rhythm:\u003c\/b\u003e Restores the youthful secretion of melatonin and normalizes cortisol levels in aged primate models.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch4 data-path-to-node=\"28\"\u003e\u003cb data-path-to-node=\"28\" data-index-in-node=\"0\"\u003e2. Oncology (Tumor Inhibition)\u003c\/b\u003e\u003c\/h4\u003e\n\u003cp data-path-to-node=\"29\"\u003eContradicting the fear that telomerase activation promotes cancer, Epithalon has shown \u003cb data-path-to-node=\"29\" data-index-in-node=\"87\"\u003eoncostatic\u003c\/b\u003e effects.\u003c\/p\u003e\n\u003cul data-path-to-node=\"30\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"30,0,0\"\u003e\u003cb data-path-to-node=\"30,0,0\" data-index-in-node=\"0\"\u003eTumor Suppression:\u003c\/b\u003e In rats with M-1 sarcoma, it inhibited tumor growth and induced \"hemorrhagic necrosis\" of the tumor mass.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"30,1,0\"\u003e\u003cb data-path-to-node=\"30,1,0\" data-index-in-node=\"0\"\u003eHER-2\/neu Suppression:\u003c\/b\u003e In transgenic mice, it downregulated the breast cancer oncogene \u003ci data-path-to-node=\"30,1,0\" data-index-in-node=\"87\"\u003eHER-2\/neu\u003c\/i\u003e, reducing tumor incidence and size.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch4 data-path-to-node=\"31\"\u003e\u003cb data-path-to-node=\"31\" data-index-in-node=\"0\"\u003e3. Retinal Repair\u003c\/b\u003e\u003c\/h4\u003e\n\u003cp data-path-to-node=\"32\"\u003eInvestigated for its ability to restore retinal function in degenerative conditions like Retinitis Pigmentosa.\u003c\/p\u003e\n\u003cul data-path-to-node=\"33\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"33,0,0\"\u003e\u003cb data-path-to-node=\"33,0,0\" data-index-in-node=\"0\"\u003eFunctional Recovery:\u003c\/b\u003e In rat models, it preserved retinal structure and increased electroretinogram (ERG) amplitude by ~75%.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003chr data-path-to-node=\"34\"\u003e\n\u003ch3 data-path-to-node=\"35\"\u003e\u003cb data-path-to-node=\"35\" data-index-in-node=\"0\"\u003eStorage \u0026amp; Handling\u003c\/b\u003e\u003c\/h3\u003e\n\u003cul data-path-to-node=\"36\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"36,0,0\"\u003e\u003cb data-path-to-node=\"36,0,0\" data-index-in-node=\"0\"\u003ePhysical State:\u003c\/b\u003e Lyophilized (Freeze-Dried) Powder.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"36,1,0\"\u003e\u003cb data-path-to-node=\"36,1,0\" data-index-in-node=\"0\"\u003eStorage (Powder):\u003c\/b\u003e Store at -20°C (Freezer). Stable for up to 24 months.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"36,2,0\"\u003e\u003cb data-path-to-node=\"36,2,0\" data-index-in-node=\"0\"\u003eReconstitution:\u003c\/b\u003e\u003c\/p\u003e\n\u003cul data-path-to-node=\"36,2,1\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"36,2,1,0,0\"\u003e\u003cb data-path-to-node=\"36,2,1,0,0\" data-index-in-node=\"0\"\u003eSolvent:\u003c\/b\u003e Bacteriostatic Water or Sterile Saline.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"36,2,1,1,0\"\u003e\u003cb data-path-to-node=\"36,2,1,1,0\" data-index-in-node=\"0\"\u003eSolubility:\u003c\/b\u003e Highly hydrophilic and soluble.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"36,3,0\"\u003e\u003cb data-path-to-node=\"36,3,0\" data-index-in-node=\"0\"\u003eStorage (Liquid):\u003c\/b\u003e Store at 4°C (Refrigerator). Use within 14-21 days.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003chr data-path-to-node=\"37\"\u003e\n\u003ch3 data-path-to-node=\"38\"\u003e\u003cb data-path-to-node=\"38\" data-index-in-node=\"0\"\u003eDisclaimer\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp data-path-to-node=\"39\"\u003e\u003cb data-path-to-node=\"39\" data-index-in-node=\"0\"\u003eFOR RESEARCH USE ONLY.\u003c\/b\u003e This product is a chemical compound intended strictly for laboratory research and development. It is not approved by the FDA for clinical use, diagnostics, or therapeutic procedures in humans or animals. The physiological and toxicological properties of this chemical have not been fully investigated.\u003c\/p\u003e","brand":"Peptagon","offers":[{"title":"10mg","offer_id":47710043111638,"sku":"EPITH-10","price":31.0,"currency_code":"USD","in_stock":true},{"title":"50mg","offer_id":47710043144406,"sku":"EPITH-50","price":54.0,"currency_code":"USD","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0783\/3085\/5638\/files\/Epithalon-10mg.png?v=1768510212","url":"https:\/\/peptagon.com\/products\/epithalon-aedg-tetrapeptide-research-peptide","provider":"Peptagon","version":"1.0","type":"link"}