{"product_id":"follistatin-344-fs344-myostatin-research-protein","title":"Follistatin 344 Research Protein – 1mg","description":"\u003ch4 data-path-to-node=\"13\"\u003e\u003cstrong\u003eFollistatin 344 (FS344) Peptide\u003c\/strong\u003e\u003c\/h4\u003e\n\u003cp data-path-to-node=\"14\"\u003e\u003cb data-path-to-node=\"14\" data-index-in-node=\"0\"\u003eIsoform:\u003c\/b\u003e Follistatin-315 (FS315) - Systemic Isoform \u003cb data-path-to-node=\"14\" data-index-in-node=\"52\"\u003eFormat:\u003c\/b\u003e Sterile Lyophilized Powder (Vial) \u003cb data-path-to-node=\"14\" data-index-in-node=\"94\"\u003eMechanism:\u003c\/b\u003e High-Affinity Ligand Trap (TGF-β Superfamily) \u003cb data-path-to-node=\"14\" data-index-in-node=\"151\"\u003ePurity:\u003c\/b\u003e \u0026gt;95% (HPLC) \u003cb data-path-to-node=\"14\" data-index-in-node=\"171\"\u003eContent:\u003c\/b\u003e 1mg per vial\u003c\/p\u003e\n\u003chr data-path-to-node=\"15\"\u003e\n\u003ch3 data-path-to-node=\"16\"\u003e\u003cb data-path-to-node=\"16\" data-index-in-node=\"0\"\u003eProduct Overview\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp data-path-to-node=\"17\"\u003e\u003cb data-path-to-node=\"17\" data-index-in-node=\"0\"\u003eFollistatin 344\u003c\/b\u003e is a recombinant glycoprotein designed to inhibit members of the TGF-β superfamily, most notably \u003cb data-path-to-node=\"17\" data-index-in-node=\"113\"\u003eMyostatin (GDF-8)\u003c\/b\u003e and \u003cb data-path-to-node=\"17\" data-index-in-node=\"135\"\u003eActivin A\u003c\/b\u003e. It corresponds to the alternatively spliced transcript that encodes the \u003cb data-path-to-node=\"17\" data-index-in-node=\"218\"\u003eFS315\u003c\/b\u003e isoform.\u003c\/p\u003e\n\u003cp data-path-to-node=\"18\"\u003eUnlike the tissue-bound FS288 isoform, Follistatin 344 contains an acidic C-terminal tail that masks its heparin-binding site. This modification allows it to circulate freely in the bloodstream, making it the preferred reagent for research requiring systemic muscle hypertrophy and metabolic modulation.\u003c\/p\u003e\n\u003chr data-path-to-node=\"19\"\u003e\n\u003ch3 data-path-to-node=\"20\"\u003e\u003cb data-path-to-node=\"20\" data-index-in-node=\"0\"\u003eMechanism of Action: The Ligand Trap\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp data-path-to-node=\"21\"\u003eFollistatin 344 acts as a \"molecular clamp,\" physically sequestering ligands to prevent them from binding to their receptors (ActRIIB).\u003c\/p\u003e\n\u003cul data-path-to-node=\"22\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"22,0,0\"\u003e\u003cb data-path-to-node=\"22,0,0\" data-index-in-node=\"0\"\u003eMyostatin Inhibition:\u003c\/b\u003e By neutralizing Myostatin, the primary negative regulator of muscle mass, Follistatin releases the \"brake\" on muscle growth, driving hypertrophy via the activation of mTOR and satellite cell fusion.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"22,1,0\"\u003e\u003cb data-path-to-node=\"22,1,0\" data-index-in-node=\"0\"\u003eActivin A Blockade:\u003c\/b\u003e Follistatin binds Activin A with even higher affinity than Myostatin. This is crucial for its anti-inflammatory effects and its ability to suppress fibrosis in models of muscular dystrophy.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"22,2,0\"\u003e\u003cb data-path-to-node=\"22,2,0\" data-index-in-node=\"0\"\u003eWnt Signaling:\u003c\/b\u003e In hair follicle research, it antagonizes BMPs to permit Wnt-mediated transition from the resting (telogen) to growth (anagen) phase.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003chr data-path-to-node=\"23\"\u003e\n\u003ch3 data-path-to-node=\"24\"\u003e\u003cb data-path-to-node=\"24\" data-index-in-node=\"0\"\u003eKey Research Applications\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp data-path-to-node=\"25\"\u003e\u003cb data-path-to-node=\"25\" data-index-in-node=\"0\"\u003e1. Musculoskeletal Hypertrophy\u003c\/b\u003e Follistatin 344 is the gold standard for inducing rapid muscle growth.\u003c\/p\u003e\n\u003cul data-path-to-node=\"26\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"26,0,0\"\u003e\u003cb data-path-to-node=\"26,0,0\" data-index-in-node=\"0\"\u003eHypertrophy:\u003c\/b\u003e Studies report gains of \u003cb data-path-to-node=\"26,0,0\" data-index-in-node=\"37\"\u003e20% to \u0026gt;100%\u003c\/b\u003e in muscle mass depending on the model (e.g., AAV gene therapy vs. peptide).\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"26,1,0\"\u003e\u003cb data-path-to-node=\"26,1,0\" data-index-in-node=\"0\"\u003eFiber Type:\u003c\/b\u003e Drives a shift toward glycolytic (Type II) fibers, increasing force generation capacity.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp data-path-to-node=\"27\"\u003e\u003cb data-path-to-node=\"27\" data-index-in-node=\"0\"\u003e2. Disease Models (Dystrophy \u0026amp; SMA)\u003c\/b\u003e\u003c\/p\u003e\n\u003cul data-path-to-node=\"28\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"28,0,0\"\u003e\u003cb data-path-to-node=\"28,0,0\" data-index-in-node=\"0\"\u003eSpinal Muscular Atrophy (SMA):\u003c\/b\u003e In murine models, daily administration extended lifespan by ~30% and increased motor neuron survival.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"28,1,0\"\u003e\u003cb data-path-to-node=\"28,1,0\" data-index-in-node=\"0\"\u003eDuchenne Muscular Dystrophy:\u003c\/b\u003e Unlike myostatin-specific antibodies, Follistatin also blocks Activin A, significantly reducing \u003cb data-path-to-node=\"28,1,0\" data-index-in-node=\"125\"\u003efibrosis\u003c\/b\u003e (scar tissue) in dystrophic muscle.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp data-path-to-node=\"29\"\u003e\u003cb data-path-to-node=\"29\" data-index-in-node=\"0\"\u003e3. Inflammation \u0026amp; Metabolism\u003c\/b\u003e\u003c\/p\u003e\n\u003cul data-path-to-node=\"30\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"30,0,0\"\u003e\u003cb data-path-to-node=\"30,0,0\" data-index-in-node=\"0\"\u003eCytokine Storm:\u003c\/b\u003e Acts as a potent anti-inflammatory by neutralizing the Activin A surge seen in sepsis and endotoxemia.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"30,1,0\"\u003e\u003cb data-path-to-node=\"30,1,0\" data-index-in-node=\"0\"\u003eMetabolic Health:\u003c\/b\u003e Hypertrophied muscle acts as a glucose sink, improving insulin sensitivity and reducing visceral fat mass in obesity models.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003chr data-path-to-node=\"31\"\u003e\n\u003ch3 data-path-to-node=\"32\"\u003e\u003cb data-path-to-node=\"32\" data-index-in-node=\"0\"\u003eStorage \u0026amp; Handling\u003c\/b\u003e\u003c\/h3\u003e\n\u003cul data-path-to-node=\"33\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"33,0,0\"\u003e\u003cb data-path-to-node=\"33,0,0\" data-index-in-node=\"0\"\u003ePhysical State:\u003c\/b\u003e Lyophilized (Freeze-Dried) Powder.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"33,1,0\"\u003e\u003cb data-path-to-node=\"33,1,0\" data-index-in-node=\"0\"\u003eStorage (Powder):\u003c\/b\u003e Store at -20°C (Freezer). Stable for up to 12 months.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"33,2,0\"\u003e\u003cb data-path-to-node=\"33,2,0\" data-index-in-node=\"0\"\u003eReconstitution:\u003c\/b\u003e\u003c\/p\u003e\n\u003cul data-path-to-node=\"33,2,1\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"33,2,1,0,0\"\u003e\u003cb data-path-to-node=\"33,2,1,0,0\" data-index-in-node=\"0\"\u003eSolvent:\u003c\/b\u003e Bacteriostatic Water or Sterile PBS (pH 7.4).\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"33,2,1,1,0\"\u003e\u003cb data-path-to-node=\"33,2,1,1,0\" data-index-in-node=\"0\"\u003eCarrier Protein:\u003c\/b\u003e Recommended to add \u003cb data-path-to-node=\"33,2,1,1,0\" data-index-in-node=\"36\"\u003e0.1% BSA\u003c\/b\u003e or HSA to prevent adsorption to the vial wall.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"33,3,0\"\u003e\u003cb data-path-to-node=\"33,3,0\" data-index-in-node=\"0\"\u003eStorage (Liquid):\u003c\/b\u003e Store at 4°C. \u003cb data-path-to-node=\"33,3,0\" data-index-in-node=\"32\"\u003eDo not freeze-thaw repeatedly.\u003c\/b\u003e Use aliquots.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003chr data-path-to-node=\"34\"\u003e\n\u003ch3 data-path-to-node=\"35\"\u003e\u003cb data-path-to-node=\"35\" data-index-in-node=\"0\"\u003eDisclaimer\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp data-path-to-node=\"36\"\u003e\u003cb data-path-to-node=\"36\" data-index-in-node=\"0\"\u003eFOR RESEARCH USE ONLY.\u003c\/b\u003e This product is a chemical compound intended strictly for laboratory research and development. It is not approved by the FDA for clinical use, diagnostics, or therapeutic procedures in humans or animals. The physiological and toxicological properties of this chemical have not been fully investigated.\u003c\/p\u003e","brand":"Peptagon","offers":[{"title":"Default Title","offer_id":47710043406550,"sku":"FOLL344-1","price":120.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0783\/3085\/5638\/files\/Follistatin-344-1mg.png?v=1768509451","url":"https:\/\/peptagon.com\/products\/follistatin-344-fs344-myostatin-research-protein","provider":"Peptagon","version":"1.0","type":"link"}