{"product_id":"ghrp-2-pralmorelin-research-peptide","title":"GHRP-2 Research Peptide – 5mg \/ 10mg","description":"\u003ch4 data-path-to-node=\"13\"\u003e\u003cstrong\u003eGHRP-2 Peptide (Lyophilized)\u003c\/strong\u003e\u003c\/h4\u003e\n\u003cp data-path-to-node=\"14\"\u003e\u003cb data-path-to-node=\"14\" data-index-in-node=\"0\"\u003eSequence:\u003c\/b\u003e D-Ala-D-2-Nal-Ala-Trp-D-Phe-Lys-NH2 \u003cb data-path-to-node=\"14\" data-index-in-node=\"46\"\u003eFormat:\u003c\/b\u003e Sterile Lyophilized Powder (Vial) \u003cb data-path-to-node=\"14\" data-index-in-node=\"88\"\u003eClass:\u003c\/b\u003e Growth Hormone Secretagogue (GHS) \u003cb data-path-to-node=\"14\" data-index-in-node=\"129\"\u003ePurity:\u003c\/b\u003e \u0026gt;98% (HPLC) \u003cb data-path-to-node=\"14\" data-index-in-node=\"149\"\u003eContent:\u003c\/b\u003e Available in 5mg and 10mg vials\u003c\/p\u003e\n\u003chr data-path-to-node=\"15\"\u003e\n\u003ch3 data-path-to-node=\"16\"\u003e\u003cb data-path-to-node=\"16\" data-index-in-node=\"0\"\u003eProduct Overview\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp data-path-to-node=\"17\"\u003e\u003cb data-path-to-node=\"17\" data-index-in-node=\"0\"\u003eGHRP-2 (Pralmorelin)\u003c\/b\u003e is a synthetic hexapeptide and a \"super-analog\" of GHRP-6. It is one of the most potent Growth Hormone Secretagogues (GHS) available, with an \u003cb data-path-to-node=\"17\" data-index-in-node=\"163\"\u003eED50 of 0.6 nmol\/kg\u003c\/b\u003e (significantly more potent than GHRP-6 or Ipamorelin).\u003c\/p\u003e\n\u003cp data-path-to-node=\"18\"\u003eUnlike selective agonists, GHRP-2 retains a promiscuous receptor profile similar to the endogenous hormone ghrelin. This results in broad physiological effects, including potent GH release, significant stimulation of the \u003cb data-path-to-node=\"18\" data-index-in-node=\"221\"\u003eHPA axis (Cortisol\/ACTH)\u003c\/b\u003e, and appetite stimulation. It is a critical reagent for researching conditions of growth failure, catabolic wasting, and hypothalamic dysfunction.\u003c\/p\u003e\n\u003chr data-path-to-node=\"19\"\u003e\n\u003ch3 data-path-to-node=\"20\"\u003e\u003cb data-path-to-node=\"20\" data-index-in-node=\"0\"\u003eMechanism of Action: Multi-Axis Stimulation\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp data-path-to-node=\"21\"\u003eGHRP-2 operates via the \u003cb data-path-to-node=\"21\" data-index-in-node=\"24\"\u003ePLC-IP3-Calcium\u003c\/b\u003e pathway, distinct from GHRH's cAMP pathway.\u003c\/p\u003e\n\u003cul data-path-to-node=\"22\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"22,0,0\"\u003e\u003cb data-path-to-node=\"22,0,0\" data-index-in-node=\"0\"\u003eGHS-R1a Activation:\u003c\/b\u003e Binds with high affinity to receptors in the pituitary and hypothalamus, triggering massive calcium influx and GH exocytosis.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"22,1,0\"\u003e\u003cb data-path-to-node=\"22,1,0\" data-index-in-node=\"0\"\u003eHPA Axis Stimulation:\u003c\/b\u003e uniquely stimulates the release of \u003cb data-path-to-node=\"22,1,0\" data-index-in-node=\"57\"\u003eACTH\u003c\/b\u003e and \u003cb data-path-to-node=\"22,1,0\" data-index-in-node=\"66\"\u003eCortisol\u003c\/b\u003e, making it a valuable probe for adrenal insufficiency (GHRP-2 Test).\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"22,2,0\"\u003e\u003cb data-path-to-node=\"22,2,0\" data-index-in-node=\"0\"\u003eSynergy:\u003c\/b\u003e When co-administered with GHRH, it produces a \u003cb data-path-to-node=\"22,2,0\" data-index-in-node=\"55\"\u003e54-fold increase\u003c\/b\u003e in GH secretion, far exceeding the sum of individual administrations.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"22,3,0\"\u003e\u003cb data-path-to-node=\"22,3,0\" data-index-in-node=\"0\"\u003eCD36 Interaction:\u003c\/b\u003e Activates the CD36 scavenger receptor, providing cardioprotection against ischemia-reperfusion injury via the RISK and SAFE kinase pathways.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003chr data-path-to-node=\"23\"\u003e\n\u003ch3 data-path-to-node=\"24\"\u003e\u003cb data-path-to-node=\"24\" data-index-in-node=\"0\"\u003eKey Research Applications\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp data-path-to-node=\"25\"\u003e\u003cb data-path-to-node=\"25\" data-index-in-node=\"0\"\u003e1. Endocrine Diagnostics \u0026amp; Growth\u003c\/b\u003e GHRP-2 is the benchmark for provoking maximal GH release.\u003c\/p\u003e\n\u003cul data-path-to-node=\"26\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"26,0,0\"\u003e\u003cb data-path-to-node=\"26,0,0\" data-index-in-node=\"0\"\u003eDiagnostic Utility:\u003c\/b\u003e Investigated as a single-agent test for both GH and ACTH deficiency, offering high specificity (100%) and sensitivity.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"26,1,0\"\u003e\u003cb data-path-to-node=\"26,1,0\" data-index-in-node=\"0\"\u003eGrowth Rescue:\u003c\/b\u003e In genetic models (like \u003ci data-path-to-node=\"26,1,0\" data-index-in-node=\"39\"\u003elit\/lit\u003c\/i\u003e mice), it stimulates growth even in the absence of functional GHRH receptors.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp data-path-to-node=\"27\"\u003e\u003cb data-path-to-node=\"27\" data-index-in-node=\"0\"\u003e2. Catabolism \u0026amp; Appetite\u003c\/b\u003e\u003c\/p\u003e\n\u003cul data-path-to-node=\"28\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"28,0,0\"\u003e\u003cb data-path-to-node=\"28,0,0\" data-index-in-node=\"0\"\u003eOrexigenic Effect:\u003c\/b\u003e Increases food intake by ~36% in human trials by activating NPY\/AgRP neurons in the hypothalamus.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"28,1,0\"\u003e\u003cb data-path-to-node=\"28,1,0\" data-index-in-node=\"0\"\u003eAnti-Catabolic:\u003c\/b\u003e Prevents muscle wasting in inflammatory states (e.g., arthritis) by downregulating the ubiquitin ligases \u003cb data-path-to-node=\"28,1,0\" data-index-in-node=\"121\"\u003eMuRF1\u003c\/b\u003e and \u003cb data-path-to-node=\"28,1,0\" data-index-in-node=\"131\"\u003eMAFbx\u003c\/b\u003e.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp data-path-to-node=\"29\"\u003e\u003cb data-path-to-node=\"29\" data-index-in-node=\"0\"\u003e3. Cardioprotection\u003c\/b\u003e\u003c\/p\u003e\n\u003cul data-path-to-node=\"30\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"30,0,0\"\u003e\u003cb data-path-to-node=\"30,0,0\" data-index-in-node=\"0\"\u003eStunning Recovery:\u003c\/b\u003e Pretreatment with GHRP-2 fully protects heart muscle from diastolic dysfunction (stunning) following ischemia.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"30,1,0\"\u003e\u003cb data-path-to-node=\"30,1,0\" data-index-in-node=\"0\"\u003eInfarct Reduction:\u003c\/b\u003e Research indicates it reduces myocardial infarct size by preventing mitochondrial permeability transition pore (mPTP) opening.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003chr data-path-to-node=\"31\"\u003e\n\u003ch3 data-path-to-node=\"32\"\u003e\u003cb data-path-to-node=\"32\" data-index-in-node=\"0\"\u003eStorage \u0026amp; Handling\u003c\/b\u003e\u003c\/h3\u003e\n\u003cul data-path-to-node=\"33\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"33,0,0\"\u003e\u003cb data-path-to-node=\"33,0,0\" data-index-in-node=\"0\"\u003ePhysical State:\u003c\/b\u003e Lyophilized (Freeze-Dried) White Powder.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"33,1,0\"\u003e\u003cb data-path-to-node=\"33,1,0\" data-index-in-node=\"0\"\u003eStorage (Powder):\u003c\/b\u003e Store at -20°C (Freezer). Stable for up to 24 months.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"33,2,0\"\u003e\u003cb data-path-to-node=\"33,2,0\" data-index-in-node=\"0\"\u003eReconstitution:\u003c\/b\u003e\u003c\/p\u003e\n\u003cul data-path-to-node=\"33,2,1\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"33,2,1,0,0\"\u003e\u003cb data-path-to-node=\"33,2,1,0,0\" data-index-in-node=\"0\"\u003eSolvent:\u003c\/b\u003e Bacteriostatic Water or Sterile Saline.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"33,2,1,1,0\"\u003e\u003cb data-path-to-node=\"33,2,1,1,0\" data-index-in-node=\"0\"\u003eSolubility:\u003c\/b\u003e Highly soluble.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"33,3,0\"\u003e\u003cb data-path-to-node=\"33,3,0\" data-index-in-node=\"0\"\u003eStorage (Liquid):\u003c\/b\u003e Store at 4°C (Refrigerator). Use within 7 days to prevent oxidation of the Tryptophan residue. \u003cb data-path-to-node=\"33,3,0\" data-index-in-node=\"113\"\u003eAvoid freeze-thaw cycles.\u003c\/b\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003chr data-path-to-node=\"34\"\u003e\n\u003ch3 data-path-to-node=\"35\"\u003e\u003cb data-path-to-node=\"35\" data-index-in-node=\"0\"\u003eDisclaimer\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp data-path-to-node=\"36\"\u003e\u003cb data-path-to-node=\"36\" data-index-in-node=\"0\"\u003eFOR RESEARCH USE ONLY.\u003c\/b\u003e This product is a chemical compound intended strictly for laboratory research and development. It is not approved by the FDA for clinical use, diagnostics, or therapeutic procedures in humans or animals. The physiological and toxicological properties of this chemical have not been fully investigated.\u003c\/p\u003e","brand":"Peptagon","offers":[{"title":"5mg","offer_id":47710089445590,"sku":"GHRP2-5","price":29.0,"currency_code":"USD","in_stock":true},{"title":"10mg","offer_id":47710089478358,"sku":"GHRP2-10","price":36.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0783\/3085\/5638\/files\/GHRP-2-5mg.png?v=1768509327","url":"https:\/\/peptagon.com\/products\/ghrp-2-pralmorelin-research-peptide","provider":"Peptagon","version":"1.0","type":"link"}