{"product_id":"gonadorelin-acetate-gnrh-research-peptide","title":"Gonadorelin Research Peptide – 5mg \/ 10mg","description":"\u003ch4 data-path-to-node=\"13\"\u003e\u003cstrong\u003eGonadorelin (GnRH) Peptide (Lyophilized)\u003c\/strong\u003e\u003c\/h4\u003e\n\u003cp data-path-to-node=\"14\"\u003e\u003cb data-path-to-node=\"14\" data-index-in-node=\"0\"\u003eSequence:\u003c\/b\u003e pGlu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH2 \u003cb data-path-to-node=\"14\" data-index-in-node=\"55\"\u003eFormat:\u003c\/b\u003e Sterile Lyophilized Powder (Vial) \u003cb data-path-to-node=\"14\" data-index-in-node=\"97\"\u003eClass:\u003c\/b\u003e Gonadotropin-Releasing Hormone Agonist \u003cb data-path-to-node=\"14\" data-index-in-node=\"143\"\u003ePurity:\u003c\/b\u003e \u0026gt;98% (HPLC) \u003cb data-path-to-node=\"14\" data-index-in-node=\"163\"\u003eContent:\u003c\/b\u003e Available in 5mg and 10mg vials\u003c\/p\u003e\n\u003chr data-path-to-node=\"15\"\u003e\n\u003ch3 data-path-to-node=\"16\"\u003e\u003cb data-path-to-node=\"16\" data-index-in-node=\"0\"\u003eProduct Overview\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp data-path-to-node=\"17\"\u003e\u003cb data-path-to-node=\"17\" data-index-in-node=\"0\"\u003eGonadorelin\u003c\/b\u003e is the synthetic acetate salt of the endogenous decapeptide Gonadotropin-Releasing Hormone (GnRH). It serves as the primary neural integrator of the hypothalamic-pituitary-gonadal (HPG) axis.\u003c\/p\u003e\n\u003cp data-path-to-node=\"18\"\u003eThis peptide functions as a \"pulse decoder.\" The frequency and amplitude of Gonadorelin pulses determine the differential secretion of \u003cb data-path-to-node=\"18\" data-index-in-node=\"135\"\u003eLuteinizing Hormone (LH)\u003c\/b\u003e and \u003cb data-path-to-node=\"18\" data-index-in-node=\"164\"\u003eFollicle-Stimulating Hormone (FSH)\u003c\/b\u003e from the pituitary gland. The 5mg and 10mg high-concentration vials are specifically designed for large-scale veterinary research (herd synchronization) and high-throughput pharmacological screening.\u003c\/p\u003e\n\u003chr data-path-to-node=\"19\"\u003e\n\u003ch3 data-path-to-node=\"20\"\u003e\u003cb data-path-to-node=\"20\" data-index-in-node=\"0\"\u003eMechanism of Action: The Pulse Decoder\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp data-path-to-node=\"21\"\u003eGonadorelin binds to the \u003cb data-path-to-node=\"21\" data-index-in-node=\"25\"\u003eGnRHR\u003c\/b\u003e (G protein-coupled receptor) on pituitary gonadotrophs, activating the Gq\/11-Phospholipase C pathway.\u003c\/p\u003e\n\u003cul data-path-to-node=\"22\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"22,0,0\"\u003e\u003cb data-path-to-node=\"22,0,0\" data-index-in-node=\"0\"\u003ePulse Frequency Coding:\u003c\/b\u003e\u003c\/p\u003e\n\u003cul data-path-to-node=\"22,0,1\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"22,0,1,0,0\"\u003e\u003cb data-path-to-node=\"22,0,1,0,0\" data-index-in-node=\"0\"\u003eHigh Frequency (~30 min):\u003c\/b\u003e Activates the \u003cb data-path-to-node=\"22,0,1,0,0\" data-index-in-node=\"40\"\u003eMAPK\/EGR1\u003c\/b\u003e pathway, preferentially stimulating \u003cb data-path-to-node=\"22,0,1,0,0\" data-index-in-node=\"86\"\u003eLH\u003c\/b\u003e synthesis (essential for ovulation).\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"22,0,1,1,0\"\u003e\u003cb data-path-to-node=\"22,0,1,1,0\" data-index-in-node=\"0\"\u003eLow Frequency (~120 min):\u003c\/b\u003e Activates the \u003cb data-path-to-node=\"22,0,1,1,0\" data-index-in-node=\"40\"\u003ecAMP\/CREB\u003c\/b\u003e pathway, preferentially stimulating \u003cb data-path-to-node=\"22,0,1,1,0\" data-index-in-node=\"86\"\u003eFSH\u003c\/b\u003e synthesis (essential for follicular growth).\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"22,1,0\"\u003e\u003cb data-path-to-node=\"22,1,0\" data-index-in-node=\"0\"\u003eCalcium Mobilization:\u003c\/b\u003e Triggers a massive influx of intracellular calcium via IP3, driving the exocytosis of stored gonadotropins.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003chr data-path-to-node=\"23\"\u003e\n\u003ch3 data-path-to-node=\"24\"\u003e\u003cb data-path-to-node=\"24\" data-index-in-node=\"0\"\u003eKey Research Applications\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp data-path-to-node=\"25\"\u003e\u003cb data-path-to-node=\"25\" data-index-in-node=\"0\"\u003e1. Veterinary \u0026amp; Herd Management (Ovsynch)\u003c\/b\u003e In dairy and livestock research, Gonadorelin is the cornerstone of estrus synchronization protocols.\u003c\/p\u003e\n\u003cul data-path-to-node=\"26\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"26,0,0\"\u003e\u003cb data-path-to-node=\"26,0,0\" data-index-in-node=\"0\"\u003eCystic Ovaries:\u003c\/b\u003e High-dose bolus administration induces the LH surge required to luteinize follicular cysts.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"26,1,0\"\u003e\u003cb data-path-to-node=\"26,1,0\" data-index-in-node=\"0\"\u003eFTAI:\u003c\/b\u003e Used in \"Ovsynch\" protocols to synchronize ovulation across a herd, allowing for Fixed-Time Artificial Insemination without the need for estrus detection.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp data-path-to-node=\"27\"\u003e\u003cb data-path-to-node=\"27\" data-index-in-node=\"0\"\u003e2. Endocrine Diagnostics\u003c\/b\u003e Used as a diagnostic probe to assess pituitary function. The \u003cb data-path-to-node=\"27\" data-index-in-node=\"86\"\u003eGonadorelin Stimulation Test\u003c\/b\u003e differentiates between hypothalamic dysfunction (where the pituitary is intact but lacks signal) and pituitary failure.\u003c\/p\u003e\n\u003cp data-path-to-node=\"28\"\u003e\u003cb data-path-to-node=\"28\" data-index-in-node=\"0\"\u003e3. Reproductive Physiology\u003c\/b\u003e Investigated for its ability to restore pulsatile secretion in conditions like Hypothalamic Amenorrhea or Kallmann Syndrome, bypassing the need for exogenous gonadotropins.\u003c\/p\u003e\n\u003chr data-path-to-node=\"29\"\u003e\n\u003ch3 data-path-to-node=\"30\"\u003e\u003cb data-path-to-node=\"30\" data-index-in-node=\"0\"\u003eComparison: Gonadorelin vs. CJC-1295\u003c\/b\u003e\u003c\/h3\u003e\n\u003cul data-path-to-node=\"31\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"31,0,0\"\u003e\u003cb data-path-to-node=\"31,0,0\" data-index-in-node=\"0\"\u003eGonadorelin:\u003c\/b\u003e Native decapeptide. Half-life of \u003cb data-path-to-node=\"31,0,0\" data-index-in-node=\"46\"\u003e2-4 minutes\u003c\/b\u003e. Used for \u003cb data-path-to-node=\"31,0,0\" data-index-in-node=\"68\"\u003epulsatile\u003c\/b\u003e stimulation of the reproductive axis (LH\/FSH).\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"31,1,0\"\u003e\u003cb data-path-to-node=\"31,1,0\" data-index-in-node=\"0\"\u003eCJC-1295 (DAC):\u003c\/b\u003e Modified GHRH analog. Half-life of \u003cb data-path-to-node=\"31,1,0\" data-index-in-node=\"51\"\u003e6-8 days\u003c\/b\u003e. Used for \u003cb data-path-to-node=\"31,1,0\" data-index-in-node=\"70\"\u003esustained\u003c\/b\u003e stimulation of the somatotropic axis (GH\/IGF-1).\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003chr data-path-to-node=\"32\"\u003e\n\u003ch3 data-path-to-node=\"33\"\u003e\u003cb data-path-to-node=\"33\" data-index-in-node=\"0\"\u003eStorage \u0026amp; Handling\u003c\/b\u003e\u003c\/h3\u003e\n\u003cul data-path-to-node=\"34\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"34,0,0\"\u003e\u003cb data-path-to-node=\"34,0,0\" data-index-in-node=\"0\"\u003ePhysical State:\u003c\/b\u003e Lyophilized (Freeze-Dried) White Powder.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"34,1,0\"\u003e\u003cb data-path-to-node=\"34,1,0\" data-index-in-node=\"0\"\u003eStorage (Powder):\u003c\/b\u003e Store at -20°C (Freezer). Stable for up to 24 months.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"34,2,0\"\u003e\u003cb data-path-to-node=\"34,2,0\" data-index-in-node=\"0\"\u003eReconstitution:\u003c\/b\u003e\u003c\/p\u003e\n\u003cul data-path-to-node=\"34,2,1\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"34,2,1,0,0\"\u003e\u003cb data-path-to-node=\"34,2,1,0,0\" data-index-in-node=\"0\"\u003eSolvent:\u003c\/b\u003e Bacteriostatic Water or Sterile Saline.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"34,2,1,1,0\"\u003e\u003cb data-path-to-node=\"34,2,1,1,0\" data-index-in-node=\"0\"\u003eSolubility:\u003c\/b\u003e Highly soluble in water.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"34,3,0\"\u003e\u003cb data-path-to-node=\"34,3,0\" data-index-in-node=\"0\"\u003eStorage (Liquid):\u003c\/b\u003e Store at 4°C (Refrigerator). Use within 7 days. For herd-level stock solutions, aliquot and freeze to prevent degradation.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003chr data-path-to-node=\"35\"\u003e\n\u003ch3 data-path-to-node=\"36\"\u003e\u003cb data-path-to-node=\"36\" data-index-in-node=\"0\"\u003eDisclaimer\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp data-path-to-node=\"37\"\u003e\u003cb data-path-to-node=\"37\" data-index-in-node=\"0\"\u003eFOR RESEARCH USE ONLY.\u003c\/b\u003e This product is a chemical compound intended strictly for laboratory research and development. It is not approved by the FDA for clinical use, diagnostics, or therapeutic procedures in humans or animals. The physiological and toxicological properties of this chemical have not been fully investigated.\u003c\/p\u003e","brand":"Peptagon","offers":[{"title":"5mg","offer_id":47710109860054,"sku":"GONAD-5","price":29.0,"currency_code":"USD","in_stock":true},{"title":"10mg","offer_id":47710109892822,"sku":"GONAD-10","price":36.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0783\/3085\/5638\/files\/Gonadorelin-10mg.png?v=1768510871","url":"https:\/\/peptagon.com\/products\/gonadorelin-acetate-gnrh-research-peptide","provider":"Peptagon","version":"1.0","type":"link"}