{"product_id":"hexarelin-acetate-ghs-r1a-research-peptide","title":"Hexarelin Acetate Research Peptide – 5mg","description":"\u003ch4 data-path-to-node=\"13\"\u003e\u003cstrong\u003eHexarelin Acetate Peptide (Lyophilized)\u003c\/strong\u003e\u003c\/h4\u003e\n\u003cp data-path-to-node=\"14\"\u003e\u003cb data-path-to-node=\"14\" data-index-in-node=\"0\"\u003eSequence:\u003c\/b\u003e His-D-2-MeTrp-Ala-Trp-D-Phe-Lys-NH2 \u003cb data-path-to-node=\"14\" data-index-in-node=\"46\"\u003eFormat:\u003c\/b\u003e Sterile Lyophilized Powder (Vial) \u003cb data-path-to-node=\"14\" data-index-in-node=\"88\"\u003eClass:\u003c\/b\u003e Growth Hormone Secretagogue (GHS) \u003cb data-path-to-node=\"14\" data-index-in-node=\"129\"\u003ePurity:\u003c\/b\u003e \u0026gt;99% (HPLC) \u003cb data-path-to-node=\"14\" data-index-in-node=\"149\"\u003eContent:\u003c\/b\u003e 5mg per vial\u003c\/p\u003e\n\u003chr data-path-to-node=\"15\"\u003e\n\u003ch3 data-path-to-node=\"16\"\u003e\u003cb data-path-to-node=\"16\" data-index-in-node=\"0\"\u003eProduct Overview\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp data-path-to-node=\"17\"\u003e\u003cb data-path-to-node=\"17\" data-index-in-node=\"0\"\u003eHexarelin\u003c\/b\u003e is a synthetic hexapeptide and a \"super-agonist\" of the Growth Hormone Secretagogue Receptor (GHS-R1a). It is chemically modified with D-amino acids (D-2-Methyl-Trp, D-Phe) to resist enzymatic degradation, giving it a prolonged half-life and potency superior to native ghrelin.\u003c\/p\u003e\n\u003cp data-path-to-node=\"18\"\u003eUnlike selective secretagogues, Hexarelin exhibits a unique dual-receptor pharmacology. It activates both the \u003cb data-path-to-node=\"18\" data-index-in-node=\"110\"\u003eGHS-R1a\u003c\/b\u003e (endocrine axis) and the \u003cb data-path-to-node=\"18\" data-index-in-node=\"143\"\u003eCD36 Scavenger Receptor\u003c\/b\u003e (cardiovascular\/metabolic axis). This pleiotropic profile makes it a critical reagent for researching cardiac ischemia, neuroprotection, and metabolic regulation.\u003c\/p\u003e\n\u003chr data-path-to-node=\"19\"\u003e\n\u003ch3 data-path-to-node=\"20\"\u003e\u003cb data-path-to-node=\"20\" data-index-in-node=\"0\"\u003eMechanism of Action: The Dual-Receptor Agonist\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp data-path-to-node=\"21\"\u003eHexarelin operates via two distinct signaling pathways:\u003c\/p\u003e\n\u003cul data-path-to-node=\"22\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"22,0,0\"\u003e\u003cb data-path-to-node=\"22,0,0\" data-index-in-node=\"0\"\u003eGHS-R1a Activation (Endocrine):\u003c\/b\u003e Binds to pituitary receptors with high affinity, triggering the PLC-IP3 pathway and massive calcium influx. This releases a \"reserve pool\" of Growth Hormone vesicles, creating a pulse larger than GHRH alone.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"22,1,0\"\u003e\u003cb data-path-to-node=\"22,1,0\" data-index-in-node=\"0\"\u003eCD36 Interaction (Cardio-Metabolic):\u003c\/b\u003e Binds to the CD36 receptor on heart and immune cells. This activates \u003cb data-path-to-node=\"22,1,0\" data-index-in-node=\"106\"\u003ePPAR-gamma\u003c\/b\u003e and the \u003cb data-path-to-node=\"22,1,0\" data-index-in-node=\"125\"\u003ePI3K\/Akt pathway\u003c\/b\u003e, promoting cell survival, mitochondrial biogenesis, and cholesterol efflux from macrophages.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003chr data-path-to-node=\"23\"\u003e\n\u003ch3 data-path-to-node=\"24\"\u003e\u003cb data-path-to-node=\"24\" data-index-in-node=\"0\"\u003eKey Research Applications\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp data-path-to-node=\"25\"\u003e\u003cb data-path-to-node=\"25\" data-index-in-node=\"0\"\u003e1. Potent GH Secretion\u003c\/b\u003e Hexarelin is one of the most powerful GH releasers known.\u003c\/p\u003e\n\u003cul data-path-to-node=\"26\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"26,0,0\"\u003e\u003cb data-path-to-node=\"26,0,0\" data-index-in-node=\"0\"\u003eSuper-Agonist:\u003c\/b\u003e Capable of stimulating GH release even in models of somatostatin inhibition.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"26,1,0\"\u003e\u003cb data-path-to-node=\"26,1,0\" data-index-in-node=\"0\"\u003eMetabolic Rescue:\u003c\/b\u003e In diabetic models, it restores GH pulsatility (though IGF-1 response depends on insulin status).\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp data-path-to-node=\"27\"\u003e\u003cb data-path-to-node=\"27\" data-index-in-node=\"0\"\u003e2. Cardioprotection \u0026amp; Ischemia\u003c\/b\u003e\u003c\/p\u003e\n\u003cul data-path-to-node=\"28\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"28,0,0\"\u003e\u003cb data-path-to-node=\"28,0,0\" data-index-in-node=\"0\"\u003eInotropy:\u003c\/b\u003e Increases cardiac contractility (squeeze) without significantly raising heart rate, improving ejection fraction in ischemic models.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"28,1,0\"\u003e\u003cb data-path-to-node=\"28,1,0\" data-index-in-node=\"0\"\u003eInfarct Reduction:\u003c\/b\u003e Pretreatment significantly reduces the size of necrotic tissue following heart attacks (ischemia-reperfusion injury).\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp data-path-to-node=\"29\"\u003e\u003cb data-path-to-node=\"29\" data-index-in-node=\"0\"\u003e3. Neuroprotection\u003c\/b\u003e\u003c\/p\u003e\n\u003cul data-path-to-node=\"30\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"30,0,0\"\u003e\u003cb data-path-to-node=\"30,0,0\" data-index-in-node=\"0\"\u003eSurvival Kinases:\u003c\/b\u003e Protects neurons from oxidative stress and toxicity (e.g., chemotherapy) by activating the PI3K\/Akt survival pathway and inhibiting caspase-3 (apoptosis).\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp data-path-to-node=\"31\"\u003e\u003cb data-path-to-node=\"31\" data-index-in-node=\"0\"\u003e4. Metabolic Regulation\u003c\/b\u003e\u003c\/p\u003e\n\u003cul data-path-to-node=\"32\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"32,0,0\"\u003e\u003cb data-path-to-node=\"32,0,0\" data-index-in-node=\"0\"\u003eLipid Metabolism:\u003c\/b\u003e Promotes the clearance of triglycerides and cholesterol via CD36\/PPAR-gamma signaling in the liver and macrophages.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003chr data-path-to-node=\"33\"\u003e\n\u003ch3 data-path-to-node=\"34\"\u003e\u003cb data-path-to-node=\"34\" data-index-in-node=\"0\"\u003eStorage \u0026amp; Handling\u003c\/b\u003e\u003c\/h3\u003e\n\u003cul data-path-to-node=\"35\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"35,0,0\"\u003e\u003cb data-path-to-node=\"35,0,0\" data-index-in-node=\"0\"\u003ePhysical State:\u003c\/b\u003e Lyophilized (Freeze-Dried) White Powder.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"35,1,0\"\u003e\u003cb data-path-to-node=\"35,1,0\" data-index-in-node=\"0\"\u003eStorage (Powder):\u003c\/b\u003e Store at -20°C (Freezer). Stable for up to 36 months.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"35,2,0\"\u003e\u003cb data-path-to-node=\"35,2,0\" data-index-in-node=\"0\"\u003eReconstitution:\u003c\/b\u003e\u003c\/p\u003e\n\u003cul data-path-to-node=\"35,2,1\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"35,2,1,0,0\"\u003e\u003cb data-path-to-node=\"35,2,1,0,0\" data-index-in-node=\"0\"\u003eSolvent:\u003c\/b\u003e Bacteriostatic Water or Sterile Saline.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"35,2,1,1,0\"\u003e\u003cb data-path-to-node=\"35,2,1,1,0\" data-index-in-node=\"0\"\u003eSolubility:\u003c\/b\u003e Highly soluble.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"35,3,0\"\u003e\u003cb data-path-to-node=\"35,3,0\" data-index-in-node=\"0\"\u003eStorage (Liquid):\u003c\/b\u003e Store at 4°C (Refrigerator). Use within 14-21 days. \u003cb data-path-to-node=\"35,3,0\" data-index-in-node=\"70\"\u003eAvoid freeze-thaw cycles.\u003c\/b\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003chr data-path-to-node=\"36\"\u003e\n\u003ch3 data-path-to-node=\"37\"\u003e\u003cb data-path-to-node=\"37\" data-index-in-node=\"0\"\u003eDisclaimer\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp data-path-to-node=\"38\"\u003e\u003cb data-path-to-node=\"38\" data-index-in-node=\"0\"\u003eFOR RESEARCH USE ONLY.\u003c\/b\u003e This product is a chemical compound intended strictly for laboratory research and development. It is not approved by the FDA for clinical use, diagnostics, or therapeutic procedures in humans or animals. The physiological and toxicological properties of this chemical have not been fully investigated.\u003c\/p\u003e","brand":"Peptagon","offers":[{"title":"Default Title","offer_id":47712186990806,"sku":"HEXAR-5","price":36.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0783\/3085\/5638\/files\/Hexarelin-5mg_bb7d043e-4e91-42ae-9b53-80008e2bb244.png?v=1768510031","url":"https:\/\/peptagon.com\/products\/hexarelin-acetate-ghs-r1a-research-peptide","provider":"Peptagon","version":"1.0","type":"link"}