{"product_id":"igf-1-lr3-long-r3-igf-1-research-peptide","title":"IGF-1 LR3 Research Peptide – 1mg","description":"\u003ch4 data-path-to-node=\"13\"\u003e\u003cstrong\u003eIGF-1 LR3 Peptide (Lyophilized)\u003c\/strong\u003e\u003c\/h4\u003e\n\u003cp data-path-to-node=\"14\"\u003e\u003cb data-path-to-node=\"14\" data-index-in-node=\"0\"\u003eSequence:\u003c\/b\u003e Modified Human IGF-1 (83 Amino Acids) \u003cb data-path-to-node=\"14\" data-index-in-node=\"48\"\u003eFormat:\u003c\/b\u003e Sterile Lyophilized Powder (Vial) \u003cb data-path-to-node=\"14\" data-index-in-node=\"90\"\u003eModifications:\u003c\/b\u003e Glu3→Arg3 Substitution + 13 AA N-Terminal Extension \u003cb data-path-to-node=\"14\" data-index-in-node=\"157\"\u003ePurity:\u003c\/b\u003e \u0026gt;95% (SDS-PAGE \/ Receptor Grade) \u003cb data-path-to-node=\"14\" data-index-in-node=\"198\"\u003eContent:\u003c\/b\u003e 1mg per vial\u003c\/p\u003e\n\u003chr data-path-to-node=\"15\"\u003e\n\u003ch3 data-path-to-node=\"16\"\u003e\u003cb data-path-to-node=\"16\" data-index-in-node=\"0\"\u003eProduct Overview\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp data-path-to-node=\"17\"\u003e\u003cb data-path-to-node=\"17\" data-index-in-node=\"0\"\u003eIGF-1 LR3 (Long R3 Insulin-like Growth Factor-1)\u003c\/b\u003e is a recombinant analog of human IGF-1, engineered to overcome the pharmacokinetic limitations of the native hormone.\u003c\/p\u003e\n\u003cp data-path-to-node=\"18\"\u003eWhile native IGF-1 has a half-life of minutes and is tightly sequestered by binding proteins (IGFBPs), IGF-1 LR3 incorporates two critical modifications:\u003c\/p\u003e\n\u003col start=\"1\" data-path-to-node=\"19\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"19,0,0\"\u003e\u003cb data-path-to-node=\"19,0,0\" data-index-in-node=\"0\"\u003eArg3 Substitution:\u003c\/b\u003e Prevents binding to IGFBPs, keeping the peptide \"free\" and bioactive.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"19,1,0\"\u003e\u003cb data-path-to-node=\"19,1,0\" data-index-in-node=\"0\"\u003eN-Terminal Extension:\u003c\/b\u003e Increases metabolic stability and half-life to \u003cb data-path-to-node=\"19,1,0\" data-index-in-node=\"69\"\u003e20-30 hours\u003c\/b\u003e.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ol\u003e\n\u003cp data-path-to-node=\"20\"\u003eThis design creates a molecule that is \u003cb data-path-to-node=\"20\" data-index-in-node=\"39\"\u003e2-3 times more potent\u003c\/b\u003e than native IGF-1 in driving anabolism and nitrogen retention in research models.\u003c\/p\u003e\n\u003chr data-path-to-node=\"21\"\u003e\n\u003ch3 data-path-to-node=\"22\"\u003e\u003cb data-path-to-node=\"22\" data-index-in-node=\"0\"\u003eMechanism of Action: The Unbound Agonist\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp data-path-to-node=\"23\"\u003eIGF-1 LR3 bypasses the body's natural regulatory buffers to deliver sustained signaling.\u003c\/p\u003e\n\u003cul data-path-to-node=\"24\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"24,0,0\"\u003e\u003cb data-path-to-node=\"24,0,0\" data-index-in-node=\"0\"\u003ePI3K\/Akt\/mTOR Pathway:\u003c\/b\u003e Activates the primary engine of protein synthesis. It recruits IRS-1 and PI3K, leading to the phosphorylation of mTOR, which drives ribosomal activity and muscle hypertrophy.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"24,1,0\"\u003e\u003cb data-path-to-node=\"24,1,0\" data-index-in-node=\"0\"\u003eFoxO Suppression:\u003c\/b\u003e Phosphorylates FoxO transcription factors, trapping them in the cytoplasm. This prevents them from transcribing muscle atrophy genes (\u003cb data-path-to-node=\"24,1,0\" data-index-in-node=\"152\"\u003eAtrogin-1\u003c\/b\u003e, \u003cb data-path-to-node=\"24,1,0\" data-index-in-node=\"163\"\u003eMuRF1\u003c\/b\u003e), effectively blocking protein breakdown.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"24,2,0\"\u003e\u003cb data-path-to-node=\"24,2,0\" data-index-in-node=\"0\"\u003eGlucose Partitioning:\u003c\/b\u003e Cross-activates Insulin\/IGF-1 Hybrid Receptors on muscle cells, driving GLUT4 translocation and glucose uptake independently of insulin levels.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003chr data-path-to-node=\"25\"\u003e\n\u003ch3 data-path-to-node=\"26\"\u003e\u003cb data-path-to-node=\"26\" data-index-in-node=\"0\"\u003eKey Research Applications\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp data-path-to-node=\"27\"\u003e\u003cb data-path-to-node=\"27\" data-index-in-node=\"0\"\u003e1. Musculoskeletal Hypertrophy\u003c\/b\u003e IGF-1 LR3 is the gold standard for research into rapid muscle growth.\u003c\/p\u003e\n\u003cul data-path-to-node=\"28\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"28,0,0\"\u003e\u003cb data-path-to-node=\"28,0,0\" data-index-in-node=\"0\"\u003ePotency:\u003c\/b\u003e In nitrogen balance studies (Tomas et al.), LR3 was significantly more effective than native IGF-1 at promoting weight gain and nitrogen retention, even with once-daily dosing.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"28,1,0\"\u003e\u003cb data-path-to-node=\"28,1,0\" data-index-in-node=\"0\"\u003eDifferentiation:\u003c\/b\u003e Promotes both the proliferation of satellite cells (via MAPK) and their fusion into myotubes (via Myogenin), supporting hyperplasia and hypertrophy.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp data-path-to-node=\"29\"\u003e\u003cb data-path-to-node=\"29\" data-index-in-node=\"0\"\u003e2. Metabolic Partitioning\u003c\/b\u003e Investigated for its \"leaning\" effect.\u003c\/p\u003e\n\u003cul data-path-to-node=\"30\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"30,0,0\"\u003e\u003cb data-path-to-node=\"30,0,0\" data-index-in-node=\"0\"\u003eNutrient Shuttling:\u003c\/b\u003e Drives glucose and amino acids into muscle tissue while suppressing insulin secretion. Low insulin disinhibits lipolysis (fat breakdown), shifting the metabolic preference toward burning fat for fuel.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp data-path-to-node=\"31\"\u003e\u003cb data-path-to-node=\"31\" data-index-in-node=\"0\"\u003e3. Cell Culture \u0026amp; Bioengineering\u003c\/b\u003e Widely used in serum-free media to maintain \u003cb data-path-to-node=\"31\" data-index-in-node=\"77\"\u003estem cells (iPSCs\/hESCs)\u003c\/b\u003e. Its stability allows for less frequent media changes while maintaining pluripotency and survival better than native growth factors.\u003c\/p\u003e\n\u003chr data-path-to-node=\"32\"\u003e\n\u003ch3 data-path-to-node=\"33\"\u003e\u003cb data-path-to-node=\"33\" data-index-in-node=\"0\"\u003eStorage \u0026amp; Handling\u003c\/b\u003e\u003c\/h3\u003e\n\u003cul data-path-to-node=\"34\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"34,0,0\"\u003e\u003cb data-path-to-node=\"34,0,0\" data-index-in-node=\"0\"\u003ePhysical State:\u003c\/b\u003e Lyophilized (Freeze-Dried) Powder.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"34,1,0\"\u003e\u003cb data-path-to-node=\"34,1,0\" data-index-in-node=\"0\"\u003eStorage (Powder):\u003c\/b\u003e Store at -20°C (Freezer). Stable for up to 12 months.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"34,2,0\"\u003e\u003cb data-path-to-node=\"34,2,0\" data-index-in-node=\"0\"\u003eReconstitution:\u003c\/b\u003e\u003c\/p\u003e\n\u003cul data-path-to-node=\"34,2,1\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"34,2,1,0,0\"\u003e\u003cb data-path-to-node=\"34,2,1,0,0\" data-index-in-node=\"0\"\u003eSolvent:\u003c\/b\u003e \u003cb data-path-to-node=\"34,2,1,0,0\" data-index-in-node=\"9\"\u003e10-100mM HCl\u003c\/b\u003e or \u003cb data-path-to-node=\"34,2,1,0,0\" data-index-in-node=\"25\"\u003eAcetic Acid\u003c\/b\u003e is often recommended for the initial dissolution to prevent aggregation, followed by dilution with sterile buffer. Alternatively, use Bacteriostatic Water if using immediately.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"34,3,0\"\u003e\u003cb data-path-to-node=\"34,3,0\" data-index-in-node=\"0\"\u003eStorage (Liquid):\u003c\/b\u003e Store at 4°C. \u003cb data-path-to-node=\"34,3,0\" data-index-in-node=\"32\"\u003eVery sensitive to degradation.\u003c\/b\u003e Use within 7 days. Avoid freeze-thaw cycles.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003chr data-path-to-node=\"35\"\u003e\n\u003ch3 data-path-to-node=\"36\"\u003e\u003cb data-path-to-node=\"36\" data-index-in-node=\"0\"\u003eDisclaimer\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp data-path-to-node=\"37\"\u003e\u003cb data-path-to-node=\"37\" data-index-in-node=\"0\"\u003eFOR RESEARCH USE ONLY.\u003c\/b\u003e This product is a chemical compound intended strictly for laboratory research and development. It is not approved by the FDA for clinical use, diagnostics, or therapeutic procedures in humans or animals. The physiological and toxicological properties of this chemical have not been fully investigated.\u003c\/p\u003e","brand":"Peptagon","offers":[{"title":"Default Title","offer_id":47712189219030,"sku":"IGF1LR3-1","price":47.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0783\/3085\/5638\/files\/IGF-1LR3-1mg.png?v=1768509272","url":"https:\/\/peptagon.com\/products\/igf-1-lr3-long-r3-igf-1-research-peptide","provider":"Peptagon","version":"1.0","type":"link"}