{"product_id":"kisspeptin-metastin-45-54-research-peptide","title":"Kisspeptin Research Peptide – 5mg \/ 10mg","description":"\u003ch4 data-path-to-node=\"13\"\u003e\u003cstrong\u003eKisspeptin Peptide (Lyophilized)\u003c\/strong\u003e\u003c\/h4\u003e\n\u003cp data-path-to-node=\"14\"\u003e\u003cb data-path-to-node=\"14\" data-index-in-node=\"0\"\u003eSequence:\u003c\/b\u003e YNWNSFGLRF-NH2 (Metastin residues 45-54) \u003cb data-path-to-node=\"14\" data-index-in-node=\"51\"\u003eFormat:\u003c\/b\u003e Sterile Lyophilized Powder (Vial) \u003cb data-path-to-node=\"14\" data-index-in-node=\"93\"\u003eReceptor:\u003c\/b\u003e KISS1R (GPR54) Agonist \u003cb data-path-to-node=\"14\" data-index-in-node=\"126\"\u003ePurity:\u003c\/b\u003e \u0026gt;98% (HPLC) \u003cb data-path-to-node=\"14\" data-index-in-node=\"146\"\u003eContent:\u003c\/b\u003e 10mg per vial\u003c\/p\u003e\n\u003chr data-path-to-node=\"15\"\u003e\n\u003ch3 data-path-to-node=\"16\"\u003e\u003cb data-path-to-node=\"16\" data-index-in-node=\"0\"\u003eProduct Overview\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp data-path-to-node=\"17\"\u003e\u003cb data-path-to-node=\"17\" data-index-in-node=\"0\"\u003eKisspeptin-10 (KP-10)\u003c\/b\u003e is the bioactive C-terminal decapeptide of the larger Kisspeptin-54 protein. It acts as the \"master switch\" of the Hypothalamic-Pituitary-Gonadal (HPG) axis.\u003c\/p\u003e\n\u003cp data-path-to-node=\"18\"\u003eResearch has established KP-10 as a potent secretagogue of \u003cb data-path-to-node=\"18\" data-index-in-node=\"59\"\u003eGonadotropin-Releasing Hormone (GnRH)\u003c\/b\u003e. By binding to the KISS1R receptor on GnRH neurons, it triggers the release of Luteinizing Hormone (LH) and Follicle-Stimulating Hormone (FSH), making it a critical tool for investigating fertility, testosterone production, and the neuroendocrine control of reproduction.\u003c\/p\u003e\n\u003chr data-path-to-node=\"19\"\u003e\n\u003ch3 data-path-to-node=\"20\"\u003e\u003cb data-path-to-node=\"20\" data-index-in-node=\"0\"\u003eMechanism of Action: The HPG Gatekeeper\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp data-path-to-node=\"21\"\u003eKisspeptin-10 functions via the Gq\/11-Phospholipase C pathway to depolarize GnRH neurons.\u003c\/p\u003e\n\u003cul data-path-to-node=\"22\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"22,0,0\"\u003e\u003cb data-path-to-node=\"22,0,0\" data-index-in-node=\"0\"\u003eGnRH Stimulation:\u003c\/b\u003e Binds to KISS1R on GnRH neurons in the hypothalamus, inhibiting potassium channels and activating TRPC channels. This causes rapid depolarization and pulsatile release of GnRH.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"22,1,0\"\u003e\u003cb data-path-to-node=\"22,1,0\" data-index-in-node=\"0\"\u003eMetabolic Integration:\u003c\/b\u003e Acts as a bridge between metabolism and reproduction. Its expression is regulated by \u003cb data-path-to-node=\"22,1,0\" data-index-in-node=\"108\"\u003eLeptin\u003c\/b\u003e, ensuring that reproductive function is coupled to energy availability.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"22,2,0\"\u003e\u003cb data-path-to-node=\"22,2,0\" data-index-in-node=\"0\"\u003eOncology (Metastasis):\u003c\/b\u003e Originally identified as \"Metastin,\" KP-10 suppresses metastasis in melanoma by inhibiting MMP-9 and inducing dormancy in disseminated tumor cells.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003chr data-path-to-node=\"23\"\u003e\n\u003ch3 data-path-to-node=\"24\"\u003e\u003cb data-path-to-node=\"24\" data-index-in-node=\"0\"\u003eKey Research Applications\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp data-path-to-node=\"25\"\u003e\u003cb data-path-to-node=\"25\" data-index-in-node=\"0\"\u003e1. Testosterone \u0026amp; Fertility\u003c\/b\u003e KP-10 is widely investigated for its ability to stimulate the release of LH and Testosterone in men without the testicular atrophy associated with exogenous TRT. It restores the HPG axis in conditions of hypogonadotropic hypogonadism.\u003c\/p\u003e\n\u003cp data-path-to-node=\"26\"\u003e\u003cb data-path-to-node=\"26\" data-index-in-node=\"0\"\u003e2. Metabolic Syndrome\u003c\/b\u003e Recent studies indicate that KP-10 can reverse the effects of a high-fat diet. In animal models, it reduced body weight, normalized blood glucose, and increased GLP-1 secretion, suggesting a role in treating obesity-related hypogonadism.\u003c\/p\u003e\n\u003cp data-path-to-node=\"27\"\u003e\u003cb data-path-to-node=\"27\" data-index-in-node=\"0\"\u003e3. Behavioral Neuroscience\u003c\/b\u003e Research using fMRI has shown that Kisspeptin administration enhances limbic brain activity in response to sexual and emotional stimuli, reducing sexual aversion and boosting social motivation and mood.\u003c\/p\u003e\n\u003chr data-path-to-node=\"28\"\u003e\n\u003ch3 data-path-to-node=\"29\"\u003e\u003cb data-path-to-node=\"29\" data-index-in-node=\"0\"\u003eStorage \u0026amp; Handling\u003c\/b\u003e\u003c\/h3\u003e\n\u003cul data-path-to-node=\"30\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"30,0,0\"\u003e\u003cb data-path-to-node=\"30,0,0\" data-index-in-node=\"0\"\u003ePhysical State:\u003c\/b\u003e Lyophilized (Freeze-Dried) White Powder.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"30,1,0\"\u003e\u003cb data-path-to-node=\"30,1,0\" data-index-in-node=\"0\"\u003eStorage (Powder):\u003c\/b\u003e Store at -20°C (Freezer). Stable for up to 36 months.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"30,2,0\"\u003e\u003cb data-path-to-node=\"30,2,0\" data-index-in-node=\"0\"\u003eReconstitution:\u003c\/b\u003e\u003c\/p\u003e\n\u003cul data-path-to-node=\"30,2,1\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"30,2,1,0,0\"\u003e\u003cb data-path-to-node=\"30,2,1,0,0\" data-index-in-node=\"0\"\u003eSolvent:\u003c\/b\u003e Sterile Water or Saline.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"30,2,1,1,0\"\u003e\u003cb data-path-to-node=\"30,2,1,1,0\" data-index-in-node=\"0\"\u003eSolubility:\u003c\/b\u003e Highly soluble.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"30,3,0\"\u003e\u003cb data-path-to-node=\"30,3,0\" data-index-in-node=\"0\"\u003eStorage (Liquid):\u003c\/b\u003e Store at 4°C (Refrigerator). \u003cb data-path-to-node=\"30,3,0\" data-index-in-node=\"47\"\u003eUse within 2-3 days.\u003c\/b\u003e KP-10 degrades rapidly in solution due to N-terminal cleavage; freeze single-use aliquots for longer storage.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003chr data-path-to-node=\"31\"\u003e\n\u003ch3 data-path-to-node=\"32\"\u003e\u003cb data-path-to-node=\"32\" data-index-in-node=\"0\"\u003eDisclaimer\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp data-path-to-node=\"33\"\u003e\u003cb data-path-to-node=\"33\" data-index-in-node=\"0\"\u003eFOR RESEARCH USE ONLY.\u003c\/b\u003e This product is a chemical compound intended strictly for laboratory research and development. It is not approved by the FDA for clinical use, diagnostics, or therapeutic procedures in humans or animals. The physiological and toxicological properties of this chemical have not been fully investigated.\u003c\/p\u003e","brand":"Peptagon","offers":[{"title":"5mg","offer_id":47712310460630,"sku":"KISSP-5","price":30.0,"currency_code":"USD","in_stock":true},{"title":"10mg","offer_id":47712310493398,"sku":"KISSP-10","price":38.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0783\/3085\/5638\/files\/Kisspeptin-5mg.png?v=1768510822","url":"https:\/\/peptagon.com\/products\/kisspeptin-metastin-45-54-research-peptide","provider":"Peptagon","version":"1.0","type":"link"}