{"product_id":"kpv-alpha-msh-11-13-research-peptide","title":"KPV Research Peptide – 10mg","description":"\u003ch4 data-path-to-node=\"13\"\u003e\u003cstrong\u003eKPV Peptide (Lyophilized)\u003c\/strong\u003e\u003c\/h4\u003e\n\u003cp data-path-to-node=\"14\"\u003e\u003cb data-path-to-node=\"14\" data-index-in-node=\"0\"\u003eSequence:\u003c\/b\u003e Lys-Pro-Val (Alpha-MSH residues 11-13) \u003cb data-path-to-node=\"14\" data-index-in-node=\"49\"\u003eFormat:\u003c\/b\u003e Sterile Lyophilized Powder (Vial) \u003cb data-path-to-node=\"14\" data-index-in-node=\"91\"\u003eMechanism:\u003c\/b\u003e Nuclear NF-κB Translocation Inhibitor \u003cb data-path-to-node=\"14\" data-index-in-node=\"140\"\u003ePurity:\u003c\/b\u003e \u0026gt;98% (HPLC) \u003cb data-path-to-node=\"14\" data-index-in-node=\"160\"\u003eContent:\u003c\/b\u003e 10mg per vial\u003c\/p\u003e\n\u003chr data-path-to-node=\"15\"\u003e\n\u003ch3 data-path-to-node=\"16\"\u003e\u003cb data-path-to-node=\"16\" data-index-in-node=\"0\"\u003eProduct Overview\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp data-path-to-node=\"17\"\u003e\u003cb data-path-to-node=\"17\" data-index-in-node=\"0\"\u003eKPV\u003c\/b\u003e is a naturally occurring tripeptide derived from the C-terminus of Alpha-Melanocyte Stimulating Hormone (α-MSH). It retains the potent anti-inflammatory and antimicrobial properties of the parent hormone but lacks the pigmentary effects (skin darkening) associated with full-length α-MSH.\u003c\/p\u003e\n\u003cp data-path-to-node=\"18\"\u003eUnlike traditional anti-inflammatories that suppress the entire immune system, KPV acts as a targeted modulator. It utilizes the \u003cb data-path-to-node=\"18\" data-index-in-node=\"129\"\u003ePepT1 transporter\u003c\/b\u003e, which is upregulated in inflamed tissues, to enter cells and block inflammatory signaling at the nuclear level. This \"seek-and-destroy\" mechanism makes it a primary candidate for researching inflammatory bowel disease (IBD), dermatitis, and wound healing.\u003c\/p\u003e\n\u003chr data-path-to-node=\"19\"\u003e\n\u003ch3 data-path-to-node=\"20\"\u003e\u003cb data-path-to-node=\"20\" data-index-in-node=\"0\"\u003eMechanism of Action: The Nuclear Shield\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp data-path-to-node=\"21\"\u003eKPV functions primarily by inhibiting the \u003cb data-path-to-node=\"21\" data-index-in-node=\"42\"\u003eNF-κB\u003c\/b\u003e pathway, the master regulator of inflammation.\u003c\/p\u003e\n\u003cul data-path-to-node=\"22\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"22,0,0\"\u003e\u003cb data-path-to-node=\"22,0,0\" data-index-in-node=\"0\"\u003eNuclear Import Blockade:\u003c\/b\u003e KPV enters the cell and binds to \u003cb data-path-to-node=\"22,0,0\" data-index-in-node=\"58\"\u003eImportin-alpha3\u003c\/b\u003e. This physically blocks the transport of NF-κB into the nucleus, preventing the transcription of pro-inflammatory cytokines like TNF-alpha and IL-6.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"22,1,0\"\u003e\u003cb data-path-to-node=\"22,1,0\" data-index-in-node=\"0\"\u003eTargeted Delivery:\u003c\/b\u003e It is actively transported into inflamed cells via the PepT1 transporter, accumulating precisely where inflammation is highest while sparing healthy tissue.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"22,2,0\"\u003e\u003cb data-path-to-node=\"22,2,0\" data-index-in-node=\"0\"\u003eAntimicrobial Activity:\u003c\/b\u003e KPV is cationic and disrupts the membranes of pathogens. Research shows it kills 95-97% of \u003ci data-path-to-node=\"22,2,0\" data-index-in-node=\"115\"\u003eS. aureus\u003c\/i\u003e (including MRSA) and \u003ci data-path-to-node=\"22,2,0\" data-index-in-node=\"146\"\u003eC. albicans\u003c\/i\u003e within hours.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003chr data-path-to-node=\"23\"\u003e\n\u003ch3 data-path-to-node=\"24\"\u003e\u003cb data-path-to-node=\"24\" data-index-in-node=\"0\"\u003eKey Research Applications\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp data-path-to-node=\"25\"\u003e\u003cb data-path-to-node=\"25\" data-index-in-node=\"0\"\u003e1. Inflammatory Bowel Disease (IBD)\u003c\/b\u003e In murine colitis models, oral KPV administration significantly reduced weight loss, colonic inflammation (MPO activity), and pro-inflammatory cytokine levels. Its efficacy is enhanced by hydrogel delivery systems that target the inflamed colon.\u003c\/p\u003e\n\u003cp data-path-to-node=\"26\"\u003e\u003cb data-path-to-node=\"26\" data-index-in-node=\"0\"\u003e2. Dermatology \u0026amp; Wound Healing\u003c\/b\u003e KPV accelerates wound closure and reduces scarring.\u003c\/p\u003e\n\u003cul data-path-to-node=\"27\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"27,0,0\"\u003e\u003cb data-path-to-node=\"27,0,0\" data-index-in-node=\"0\"\u003eRe-epithelialization:\u003c\/b\u003e Promotes rapid keratinocyte migration, closing wounds faster.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"27,1,0\"\u003e\u003cb data-path-to-node=\"27,1,0\" data-index-in-node=\"0\"\u003eAnti-Fibrotic:\u003c\/b\u003e Reduces inflammation early in the healing process, preventing the excessive collagen deposition that leads to scars.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"27,2,0\"\u003e\u003cb data-path-to-node=\"27,2,0\" data-index-in-node=\"0\"\u003ePsoriasis\/Dermatitis:\u003c\/b\u003e Investigated for its ability to calm skin inflammation without the side effects of topical steroids.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp data-path-to-node=\"28\"\u003e\u003cb data-path-to-node=\"28\" data-index-in-node=\"0\"\u003e3. Antimicrobial Defense\u003c\/b\u003e Unlike antibiotics, KPV has a dual mechanism: it kills bacteria\/fungi directly via membrane disruption \u003ci data-path-to-node=\"28\" data-index-in-node=\"128\"\u003eand\u003c\/i\u003e suppresses the host inflammation caused by the infection. It is effective against biofilms and resistant strains like MRSA.\u003c\/p\u003e\n\u003chr data-path-to-node=\"29\"\u003e\n\u003ch3 data-path-to-node=\"30\"\u003e\u003cb data-path-to-node=\"30\" data-index-in-node=\"0\"\u003eStorage \u0026amp; Handling\u003c\/b\u003e\u003c\/h3\u003e\n\u003cul data-path-to-node=\"31\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"31,0,0\"\u003e\u003cb data-path-to-node=\"31,0,0\" data-index-in-node=\"0\"\u003ePhysical State:\u003c\/b\u003e Lyophilized (Freeze-Dried) White Powder.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"31,1,0\"\u003e\u003cb data-path-to-node=\"31,1,0\" data-index-in-node=\"0\"\u003eStorage (Powder):\u003c\/b\u003e Store at -20°C (Freezer). Stable for up to 36 months.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"31,2,0\"\u003e\u003cb data-path-to-node=\"31,2,0\" data-index-in-node=\"0\"\u003eReconstitution:\u003c\/b\u003e\u003c\/p\u003e\n\u003cul data-path-to-node=\"31,2,1\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"31,2,1,0,0\"\u003e\u003cb data-path-to-node=\"31,2,1,0,0\" data-index-in-node=\"0\"\u003eSolvent:\u003c\/b\u003e Sterile Water or Saline.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"31,2,1,1,0\"\u003e\u003cb data-path-to-node=\"31,2,1,1,0\" data-index-in-node=\"0\"\u003eSolubility:\u003c\/b\u003e Highly soluble due to hydrophilic residues.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"31,3,0\"\u003e\u003cb data-path-to-node=\"31,3,0\" data-index-in-node=\"0\"\u003eStorage (Liquid):\u003c\/b\u003e Store at 4°C (Refrigerator). Use within 14-21 days.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003chr data-path-to-node=\"32\"\u003e\n\u003ch3 data-path-to-node=\"33\"\u003e\u003cb data-path-to-node=\"33\" data-index-in-node=\"0\"\u003eDisclaimer\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp data-path-to-node=\"34\"\u003e\u003cb data-path-to-node=\"34\" data-index-in-node=\"0\"\u003eFOR RESEARCH USE ONLY.\u003c\/b\u003e This product is a chemical compound intended strictly for laboratory research and development. It is not approved by the FDA for clinical use, diagnostics, or therapeutic procedures in humans or animals. The physiological and toxicological properties of this chemical have not been fully investigated.\u003c\/p\u003e","brand":"Peptagon","offers":[{"title":"Default Title","offer_id":47712310952150,"sku":"KPV-10","price":31.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0783\/3085\/5638\/files\/KPV-10mg.png?v=1768507503","url":"https:\/\/peptagon.com\/products\/kpv-alpha-msh-11-13-research-peptide","provider":"Peptagon","version":"1.0","type":"link"}