{"product_id":"ll-37-complex-human-cathelicidin-research-peptide","title":"LL-37 Complex Research Peptide – 5mg","description":"\u003ch4 data-path-to-node=\"13\"\u003e\u003cstrong\u003eLL-37 Complex Peptide (Lyophilized)\u003c\/strong\u003e\u003c\/h4\u003e\n\u003cp data-path-to-node=\"14\"\u003e\u003cb data-path-to-node=\"14\" data-index-in-node=\"0\"\u003eSequence:\u003c\/b\u003e LLGDFFRKSK EKIGKEFKRI VQRIKDFLRN LVPRTES \u003cb data-path-to-node=\"14\" data-index-in-node=\"51\"\u003eFormat:\u003c\/b\u003e Sterile Lyophilized Powder (Vial) \u003cb data-path-to-node=\"14\" data-index-in-node=\"93\"\u003eStructure:\u003c\/b\u003e Amphipathic Alpha-Helix \u003cb data-path-to-node=\"14\" data-index-in-node=\"128\"\u003ePurity:\u003c\/b\u003e \u0026gt;95% (HPLC) \u003cb data-path-to-node=\"14\" data-index-in-node=\"148\"\u003eContent:\u003c\/b\u003e 5mg per vial\u003c\/p\u003e\n\u003chr data-path-to-node=\"15\"\u003e\n\u003ch3 data-path-to-node=\"16\"\u003e\u003cb data-path-to-node=\"16\" data-index-in-node=\"0\"\u003eProduct Overview\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp data-path-to-node=\"17\"\u003e\u003cb data-path-to-node=\"17\" data-index-in-node=\"0\"\u003eLL-37 Complex\u003c\/b\u003e refers to the research-grade formulation of the human cathelicidin peptide, designed to investigate its interactions with nucleic acids and host membranes.\u003c\/p\u003e\n\u003cp data-path-to-node=\"18\"\u003eWhile native LL-37 is a potent antimicrobial, this specific formulation is often utilized to study the peptide's \"alarmin\" function—its ability to form complexes with self-DNA\/RNA. These complexes are critical triggers in autoimmune pathways (like psoriasis and lupus) and are potent stimulators of angiogenesis and wound healing via EGFR transactivation.\u003c\/p\u003e\n\u003chr data-path-to-node=\"19\"\u003e\n\u003ch3 data-path-to-node=\"20\"\u003e\u003cb data-path-to-node=\"20\" data-index-in-node=\"0\"\u003eMechanism of Action: The Nucleic Acid Carrier\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp data-path-to-node=\"21\"\u003eLL-37 acts as a molecular bridge between the innate immune system and host tissues.\u003c\/p\u003e\n\u003cul data-path-to-node=\"22\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"22,0,0\"\u003e\u003cb data-path-to-node=\"22,0,0\" data-index-in-node=\"0\"\u003eNucleic Acid Complexation:\u003c\/b\u003e The cationic peptide binds to anionic DNA and RNA released from damaged cells. It protects these nucleic acids from degradation and transports them into immune cells (pDCs), where they activate \u003cb data-path-to-node=\"22,0,0\" data-index-in-node=\"221\"\u003eTLR9\u003c\/b\u003e and \u003cb data-path-to-node=\"22,0,0\" data-index-in-node=\"230\"\u003eTLR7\u003c\/b\u003e, triggering interferon responses.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"22,1,0\"\u003e\u003cb data-path-to-node=\"22,1,0\" data-index-in-node=\"0\"\u003eEGFR Transactivation:\u003c\/b\u003e In epithelial tissues, LL-37 activates metalloproteinases (ADAMs) which cleave and release HB-EGF. This transactivates the \u003cb data-path-to-node=\"22,1,0\" data-index-in-node=\"145\"\u003eEpidermal Growth Factor Receptor (EGFR)\u003c\/b\u003e, driving keratinocyte migration and re-epithelialization.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"22,2,0\"\u003e\u003cb data-path-to-node=\"22,2,0\" data-index-in-node=\"0\"\u003eAngiogenesis:\u003c\/b\u003e Stimulates the proliferation of endothelial cells and the formation of new blood vessels via the FPR2 receptor and VEGF upregulation.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003chr data-path-to-node=\"23\"\u003e\n\u003ch3 data-path-to-node=\"24\"\u003e\u003cb data-path-to-node=\"24\" data-index-in-node=\"0\"\u003eKey Research Applications\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp data-path-to-node=\"25\"\u003e\u003cb data-path-to-node=\"25\" data-index-in-node=\"0\"\u003e1. Autoimmunity (Psoriasis\/Lupus)\u003c\/b\u003e The \"LL-37 Complex\" is the central autoantigen in psoriasis research. It converts inert self-DNA into a potent inflammatory signal, driving the Th17\/IFN-alpha axis.\u003c\/p\u003e\n\u003cp data-path-to-node=\"26\"\u003e\u003cb data-path-to-node=\"26\" data-index-in-node=\"0\"\u003e2. Chronic Wound Healing\u003c\/b\u003e Investigated for its ability to convert chronic, non-healing wounds into active repair sites by stimulating angiogenesis and neutralizing bacterial biofilms.\u003c\/p\u003e\n\u003cp data-path-to-node=\"27\"\u003e\u003cb data-path-to-node=\"27\" data-index-in-node=\"0\"\u003e3. Biofilm Disruption\u003c\/b\u003e Unlike antibiotics, LL-37 disrupts the physical integrity of bacterial biofilms (e.g., \u003ci data-path-to-node=\"27\" data-index-in-node=\"109\"\u003eP. aeruginosa\u003c\/i\u003e) at sub-lethal concentrations by downregulating quorum sensing systems.\u003c\/p\u003e\n\u003chr data-path-to-node=\"28\"\u003e\n\u003ch3 data-path-to-node=\"29\"\u003e\u003cb data-path-to-node=\"29\" data-index-in-node=\"0\"\u003eStorage \u0026amp; Handling\u003c\/b\u003e\u003c\/h3\u003e\n\u003cul data-path-to-node=\"30\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"30,0,0\"\u003e\u003cb data-path-to-node=\"30,0,0\" data-index-in-node=\"0\"\u003ePhysical State:\u003c\/b\u003e Lyophilized (Freeze-Dried) White Powder.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"30,1,0\"\u003e\u003cb data-path-to-node=\"30,1,0\" data-index-in-node=\"0\"\u003eStorage (Powder):\u003c\/b\u003e Store at -20°C (Freezer). Stable for up to 24 months.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"30,2,0\"\u003e\u003cb data-path-to-node=\"30,2,0\" data-index-in-node=\"0\"\u003eReconstitution:\u003c\/b\u003e\u003c\/p\u003e\n\u003cul data-path-to-node=\"30,2,1\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"30,2,1,0,0\"\u003e\u003cb data-path-to-node=\"30,2,1,0,0\" data-index-in-node=\"0\"\u003eSolvent:\u003c\/b\u003e Sterile Water (Endotoxin-Free). \u003cb data-path-to-node=\"30,2,1,0,0\" data-index-in-node=\"41\"\u003eAvoid high-salt buffers\u003c\/b\u003e initially to prevent aggregation.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"30,2,1,1,0\"\u003e\u003cb data-path-to-node=\"30,2,1,1,0\" data-index-in-node=\"0\"\u003eConcentration:\u003c\/b\u003e Reconstitute to \u0026gt;100 µg\/mL to minimize adsorption loss.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"30,3,0\"\u003e\u003cb data-path-to-node=\"30,3,0\" data-index-in-node=\"0\"\u003eStorage (Liquid):\u003c\/b\u003e Store at 4°C (Refrigerator). Use within 7 days.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003chr data-path-to-node=\"31\"\u003e\n\u003ch3 data-path-to-node=\"32\"\u003e\u003cb data-path-to-node=\"32\" data-index-in-node=\"0\"\u003eDisclaimer\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp data-path-to-node=\"33\"\u003e\u003cb data-path-to-node=\"33\" data-index-in-node=\"0\"\u003eFOR RESEARCH USE ONLY.\u003c\/b\u003e This product is a chemical compound intended strictly for laboratory research and development. It is not approved by the FDA for clinical use, diagnostics, or therapeutic procedures in humans or animals. The physiological and toxicological properties of this chemical have not been fully investigated.\u003c\/p\u003e","brand":"Peptagon","offers":[{"title":"Default Title","offer_id":47712362070230,"sku":"LL37-5","price":52.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0783\/3085\/5638\/files\/LL-37-Complex-5mg_2fc0c889-f93c-4f7c-8d3b-841ebe413934.png?v=1768507565","url":"https:\/\/peptagon.com\/products\/ll-37-complex-human-cathelicidin-research-peptide","provider":"Peptagon","version":"1.0","type":"link"}