{"product_id":"ll-37-human-cathelicidin-research-peptide","title":"LL-37 Research Peptide – 5mg \/ 10mg","description":"\u003ch2 data-path-to-node=\"13\"\u003e\u003cstrong\u003eLL-37 Peptide (Lyophilized)\u003c\/strong\u003e\u003c\/h2\u003e\n\u003ch2 data-section-id=\"1qhk4i3\" data-start=\"940\" data-end=\"959\"\u003eSpecifications\u003c\/h2\u003e\n\u003cp data-start=\"960\" data-end=\"1168\"\u003e\u003cstrong data-start=\"960\" data-end=\"973\"\u003eSequence:\u003c\/strong\u003e LLGDFFRKSK EKIGKEFKRI VQRIKDFLRN LVPRTES\u003cbr data-start=\"1014\" data-end=\"1017\"\u003e\u003cstrong data-start=\"1017\" data-end=\"1028\"\u003eFormat:\u003c\/strong\u003e Sterile Lyophilized Powder (Vial)\u003cbr data-start=\"1062\" data-end=\"1065\"\u003e\u003cstrong data-start=\"1065\" data-end=\"1077\"\u003eContent:\u003c\/strong\u003e 10mg per vial\u003cbr data-start=\"1091\" data-end=\"1094\"\u003e\u003cstrong data-start=\"1094\" data-end=\"1104\"\u003eClass:\u003c\/strong\u003e Host Defense Peptide (Cathelicidin)\u003cbr data-start=\"1140\" data-end=\"1143\"\u003e\u003cstrong data-start=\"1143\" data-end=\"1154\"\u003ePurity:\u003c\/strong\u003e ≥98% (HPLC)\u003c\/p\u003e\n\u003cp data-start=\"1170\" data-end=\"1259\"\u003e\u003cstrong data-start=\"1170\" data-end=\"1187\"\u003eIntended Use:\u003c\/strong\u003e For laboratory research purposes only. Not for human or veterinary use.\u003c\/p\u003e\n\u003chr data-start=\"1261\" data-end=\"1264\"\u003e\n\u003ch2 data-section-id=\"53drpp\" data-start=\"1266\" data-end=\"1287\"\u003eProduct Overview\u003c\/h2\u003e\n\u003cp data-start=\"1289\" data-end=\"1592\"\u003eLL-37 is the only cathelicidin-derived peptide identified in humans and plays a central role in innate immune system signaling. It is classified as a host defense peptide and is widely studied for its interaction with microbial membranes, immune signaling pathways, and cellular communication processes.\u003c\/p\u003e\n\u003cp data-start=\"1594\" data-end=\"1903\"\u003eLL-37 functions as a multifunctional signaling peptide, participating in antimicrobial defense, immune cell recruitment, and modulation of inflammatory pathways. Unlike traditional small-molecule antibiotics, LL-37 operates through biophysical membrane interactions and receptor-mediated signaling mechanisms.\u003c\/p\u003e\n\u003cp data-start=\"1905\" data-end=\"2092\"\u003eIn research settings, LL-37 is utilized to investigate antimicrobial peptide behavior, host-pathogen interactions, and signaling pathways associated with inflammation and tissue response.\u003c\/p\u003e\n\u003chr data-start=\"2094\" data-end=\"2097\"\u003e\n\u003ch2 data-section-id=\"10snmn7\" data-start=\"2099\" data-end=\"2121\"\u003eWhy This Peptide?\u003c\/h2\u003e\n\u003cp data-start=\"2123\" data-end=\"2287\"\u003eLL-37 is one of the most extensively studied human antimicrobial peptides due to its dual role in both direct microbial interaction and immune signaling modulation.\u003c\/p\u003e\n\u003cp data-start=\"2289\" data-end=\"2317\"\u003eKey characteristics include:\u003c\/p\u003e\n\u003cul data-start=\"2319\" data-end=\"2605\"\u003e\n\u003cli data-section-id=\"1t6ipz0\" data-start=\"2319\" data-end=\"2384\"\u003eAmphipathic α-helical structure enabling membrane interaction\u003c\/li\u003e\n\u003cli data-section-id=\"cn3lwm\" data-start=\"2385\" data-end=\"2446\"\u003eBroad interaction with microbial membranes and endotoxins\u003c\/li\u003e\n\u003cli data-section-id=\"grioyr\" data-start=\"2447\" data-end=\"2518\"\u003eInvolvement in immune signaling and cellular communication pathways\u003c\/li\u003e\n\u003cli data-section-id=\"171p6jh\" data-start=\"2519\" data-end=\"2605\"\u003eActivity across multiple research models (microbial, immune, and tissue signaling)\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp data-start=\"2607\" data-end=\"2690\"\u003eThese features make LL-37 a foundational compound in host defense peptide research.\u003c\/p\u003e\n\u003chr data-start=\"2692\" data-end=\"2695\"\u003e\n\u003ch2 data-section-id=\"178yx1o\" data-start=\"2697\" data-end=\"2766\"\u003eMechanism of Action: Membrane Interaction \u0026amp; Signaling Modulation\u003c\/h2\u003e\n\u003cp data-start=\"2768\" data-end=\"2859\"\u003eLL-37 exhibits a multimodal mechanism depending on environmental context and concentration.\u003c\/p\u003e\n\u003ch3 data-section-id=\"vshl77\" data-start=\"2861\" data-end=\"2911\"\u003eMembrane Interaction (Antimicrobial Context)\u003c\/h3\u003e\n\u003cp data-start=\"2912\" data-end=\"3103\"\u003eLL-37 forms an amphipathic α-helix that interacts with negatively charged microbial membranes. This interaction can lead to membrane destabilization and pore formation in experimental models.\u003c\/p\u003e\n\u003ch3 data-section-id=\"iz6jw6\" data-start=\"3105\" data-end=\"3130\"\u003eBiofilm Interaction\u003c\/h3\u003e\n\u003cp data-start=\"3131\" data-end=\"3317\"\u003eLL-37 has been studied in models examining bacterial quorum sensing systems and biofilm formation dynamics, including effects on signaling pathways associated with microbial aggregation.\u003c\/p\u003e\n\u003ch3 data-section-id=\"xq70dp\" data-start=\"3319\" data-end=\"3348\"\u003eEndotoxin (LPS) Binding\u003c\/h3\u003e\n\u003cp data-start=\"3349\" data-end=\"3509\"\u003eLL-37 binds lipopolysaccharide (LPS), allowing investigation into pathways related to Toll-like receptor (TLR4) signaling and downstream inflammatory responses.\u003c\/p\u003e\n\u003ch3 data-section-id=\"hydtql\" data-start=\"3511\" data-end=\"3544\"\u003eImmune Signaling Modulation\u003c\/h3\u003e\n\u003cp data-start=\"3545\" data-end=\"3625\"\u003eLL-37 interacts with multiple receptors involved in immune signaling, including:\u003c\/p\u003e\n\u003cul data-start=\"3627\" data-end=\"3713\"\u003e\n\u003cli data-section-id=\"69c971\" data-start=\"3627\" data-end=\"3661\"\u003eFPR2 (formyl peptide receptor)\u003c\/li\u003e\n\u003cli data-section-id=\"1s7xh4d\" data-start=\"3662\" data-end=\"3679\"\u003eP2X7 receptor\u003c\/li\u003e\n\u003cli data-section-id=\"o5ut7l\" data-start=\"3680\" data-end=\"3713\"\u003eEGFR transactivation pathways\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp data-start=\"3715\" data-end=\"3829\"\u003eThese interactions are studied in relation to immune cell recruitment, signaling cascades, and pathway modulation.\u003c\/p\u003e\n\u003chr data-start=\"3831\" data-end=\"3834\"\u003e\n\u003ch2 data-section-id=\"1k1p0ls\" data-start=\"3836\" data-end=\"3867\"\u003ePreclinical Research Areas\u003c\/h2\u003e\n\u003cp data-start=\"3869\" data-end=\"4054\"\u003e\u003cstrong data-start=\"3869\" data-end=\"3906\"\u003e1. Antimicrobial Peptide Research\u003c\/strong\u003e\u003cbr data-start=\"3906\" data-end=\"3909\"\u003eStudied in models involving Gram-positive, Gram-negative, and fungal organisms, focusing on membrane interaction and microbial response pathways.\u003c\/p\u003e\n\u003cp data-start=\"4056\" data-end=\"4183\"\u003e\u003cstrong data-start=\"4056\" data-end=\"4099\"\u003e2. Biofilm \u0026amp; Microbial Signaling Models\u003c\/strong\u003e\u003cbr data-start=\"4099\" data-end=\"4102\"\u003eUsed in research examining quorum sensing systems and biofilm formation dynamics.\u003c\/p\u003e\n\u003cp data-start=\"4185\" data-end=\"4348\"\u003e\u003cstrong data-start=\"4185\" data-end=\"4232\"\u003e3. Immune Signaling \u0026amp; Inflammation Research\u003c\/strong\u003e\u003cbr data-start=\"4232\" data-end=\"4235\"\u003eInvestigated for its role in immune cell signaling, cytokine pathway modulation, and receptor-level interactions.\u003c\/p\u003e\n\u003cp data-start=\"4350\" data-end=\"4516\"\u003e\u003cstrong data-start=\"4350\" data-end=\"4391\"\u003e4. Tissue \u0026amp; Cellular Signaling Models\u003c\/strong\u003e\u003cbr data-start=\"4391\" data-end=\"4394\"\u003eStudied in keratinocyte and endothelial cell models to evaluate signaling pathways associated with cellular communication.\u003c\/p\u003e\n\u003cp data-start=\"4518\" data-end=\"4709\"\u003e\u003cstrong data-start=\"4518\" data-end=\"4566\"\u003e5. Oncology Signaling Context (Experimental)\u003c\/strong\u003e\u003cbr data-start=\"4566\" data-end=\"4569\"\u003eLL-37 has been evaluated in models examining signaling pathways in different tissue environments, with context-dependent effects observed.\u003c\/p\u003e\n\u003chr data-start=\"4711\" data-end=\"4714\"\u003e\n\u003ch2 data-section-id=\"ce0tqk\" data-start=\"4716\" data-end=\"4733\"\u003eApplications\u003c\/h2\u003e\n\u003cul data-start=\"4735\" data-end=\"4944\"\u003e\n\u003cli data-section-id=\"blzgyi\" data-start=\"4735\" data-end=\"4776\"\u003eAntimicrobial peptide research models\u003c\/li\u003e\n\u003cli data-section-id=\"1y19lfu\" data-start=\"4777\" data-end=\"4815\"\u003eBiofilm and quorum sensing studies\u003c\/li\u003e\n\u003cli data-section-id=\"1k4sqk1\" data-start=\"4816\" data-end=\"4853\"\u003eImmune signaling pathway analysis\u003c\/li\u003e\n\u003cli data-section-id=\"1aozsy0\" data-start=\"4854\" data-end=\"4905\"\u003eCell culture (keratinocyte, immune cell models)\u003c\/li\u003e\n\u003cli data-section-id=\"1e0nmmg\" data-start=\"4906\" data-end=\"4944\"\u003eHost-pathogen interaction research\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003chr data-start=\"4946\" data-end=\"4949\"\u003e\n\u003ch2 data-section-id=\"1jtb6ys\" data-start=\"4951\" data-end=\"4975\"\u003eResearch Advantages\u003c\/h2\u003e\n\u003cul data-start=\"4977\" data-end=\"5270\"\u003e\n\u003cli data-section-id=\"4zq4gk\" data-start=\"4977\" data-end=\"5015\"\u003eHuman-derived host defense peptide\u003c\/li\u003e\n\u003cli data-section-id=\"5pj6xb\" data-start=\"5016\" data-end=\"5079\"\u003eAmphipathic structure enabling membrane interaction studies\u003c\/li\u003e\n\u003cli data-section-id=\"958lu5\" data-start=\"5080\" data-end=\"5147\"\u003eBroad applicability across microbial and immune research models\u003c\/li\u003e\n\u003cli data-section-id=\"1dil6zk\" data-start=\"5148\" data-end=\"5205\"\u003eMulti-pathway signaling relevance (immune + cellular)\u003c\/li\u003e\n\u003cli data-section-id=\"1ocm8cy\" data-start=\"5206\" data-end=\"5270\"\u003eWell-characterized peptide with extensive literature support\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003chr data-start=\"5272\" data-end=\"5275\"\u003e\n\u003ch2 data-section-id=\"1qk69px\" data-start=\"5277\" data-end=\"5300\"\u003eStorage \u0026amp; Handling\u003c\/h2\u003e\n\u003cp data-start=\"5302\" data-end=\"5357\"\u003e\u003cstrong data-start=\"5302\" data-end=\"5321\"\u003ePhysical State:\u003c\/strong\u003e Lyophilized (freeze-dried) powder\u003c\/p\u003e\n\u003cp data-start=\"5359\" data-end=\"5426\"\u003e\u003cstrong data-start=\"5359\" data-end=\"5380\"\u003eStorage (Powder):\u003c\/strong\u003e Store at -20°C. Stable for extended storage\u003c\/p\u003e\n\u003cp data-start=\"5428\" data-end=\"5449\"\u003e\u003cstrong data-start=\"5428\" data-end=\"5447\"\u003eReconstitution:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cul data-start=\"5450\" data-end=\"5586\"\u003e\n\u003cli data-section-id=\"99vxfy\" data-start=\"5450\" data-end=\"5471\"\u003eUse sterile water\u003c\/li\u003e\n\u003cli data-section-id=\"twzdsl\" data-start=\"5472\" data-end=\"5532\"\u003eAvoid high-salt buffers initially to prevent aggregation\u003c\/li\u003e\n\u003cli data-section-id=\"19zbkhw\" data-start=\"5533\" data-end=\"5586\"\u003eUse low-binding labware (LL-37 adheres to surfaces)\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp data-start=\"5588\" data-end=\"5661\"\u003e\u003cstrong data-start=\"5588\" data-end=\"5609\"\u003eStorage (Liquid):\u003c\/strong\u003e\u003cbr data-start=\"5609\" data-end=\"5612\"\u003eStore at 4°C and use within a limited timeframe\u003c\/p\u003e\n\u003chr data-start=\"5663\" data-end=\"5666\"\u003e\n\u003ch2 data-section-id=\"9rcx7q\" data-start=\"5668\" data-end=\"5683\"\u003eDisclaimer\u003c\/h2\u003e\n\u003cp data-start=\"5685\" data-end=\"6009\"\u003eFOR RESEARCH USE ONLY. This product is a chemical compound intended strictly for laboratory research and development. It is not approved by the FDA for clinical use, diagnostics, or therapeutic procedures in humans or animals. The physiological and toxicological properties of this chemical have not been fully investigated.\u003c\/p\u003e","brand":"Peptagon","offers":[{"title":"5mg","offer_id":48170384949462,"sku":"LL37-NC-5","price":33.0,"currency_code":"USD","in_stock":false},{"title":"10mg","offer_id":48170384982230,"sku":"LL37-NC-10","price":63.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0783\/3085\/5638\/files\/LL-37-5mg.png?v=1768507525","url":"https:\/\/peptagon.com\/products\/ll-37-human-cathelicidin-research-peptide","provider":"Peptagon","version":"1.0","type":"link"}