{"product_id":"mgf-mechano-growth-factor-igf-1ec-research-peptide","title":"MGF Research Peptide – 5mg","description":"\u003ch4 data-path-to-node=\"13\"\u003e\u003cstrong\u003eMGF Peptide (Lyophilized)\u003c\/strong\u003e\u003c\/h4\u003e\n\u003cp data-path-to-node=\"14\"\u003e\u003cb data-path-to-node=\"14\" data-index-in-node=\"0\"\u003eSequence:\u003c\/b\u003e Tyr-Gln-Pro-Pro-Ser-Thr-Asn-Lys-Asn-Thr-Lys-Ser-Gln-Arg-Arg-Lys-Gly-Ser-Thr-Phe-Glu-Glu-Arg-Lys \u003cb data-path-to-node=\"14\" data-index-in-node=\"106\"\u003eFormat:\u003c\/b\u003e Sterile Lyophilized Powder (Vial) \u003cb data-path-to-node=\"14\" data-index-in-node=\"148\"\u003eIsoform:\u003c\/b\u003e IGF-1Ec C-Terminal Peptide \u003cb data-path-to-node=\"14\" data-index-in-node=\"184\"\u003ePurity:\u003c\/b\u003e \u0026gt;98% (HPLC) \u003cb data-path-to-node=\"14\" data-index-in-node=\"204\"\u003eContent:\u003c\/b\u003e 5mg per vial\u003c\/p\u003e\n\u003chr data-path-to-node=\"15\"\u003e\n\u003ch3 data-path-to-node=\"16\"\u003e\u003cb data-path-to-node=\"16\" data-index-in-node=\"0\"\u003eProduct Overview\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp data-path-to-node=\"17\"\u003e\u003cb data-path-to-node=\"17\" data-index-in-node=\"0\"\u003eMGF (Mechano Growth Factor)\u003c\/b\u003e is a splice variant of the IGF-1 gene (IGF-1Ec), naturally expressed in muscle tissue in response to mechanical stress and damage.\u003c\/p\u003e\n\u003cp data-path-to-node=\"18\"\u003eUnlike systemic IGF-1 which drives differentiation, MGF acts as a local \u003cb data-path-to-node=\"18\" data-index-in-node=\"72\"\u003estem cell activator\u003c\/b\u003e. It triggers the proliferation of quiescent satellite cells (muscle stem cells), expanding the pool of myoblasts available for repair. It is a critical research tool for investigating the initial phase of muscle regeneration, neuroprotection, and cardiac repair.\u003c\/p\u003e\n\u003chr data-path-to-node=\"19\"\u003e\n\u003ch3 data-path-to-node=\"20\"\u003e\u003cb data-path-to-node=\"20\" data-index-in-node=\"0\"\u003eMechanism of Action: The \"Activation\" Signal\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp data-path-to-node=\"21\"\u003eMGF operates via a unique signaling pathway distinct from the IGF-1 receptor.\u003c\/p\u003e\n\u003cul data-path-to-node=\"22\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"22,0,0\"\u003e\u003cb data-path-to-node=\"22,0,0\" data-index-in-node=\"0\"\u003eSatellite Cell Activation:\u003c\/b\u003e MGF drives quiescent satellite cells into the cell cycle (G0 -\u0026gt; G1), promoting rapid proliferation via the \u003cb data-path-to-node=\"22,0,0\" data-index-in-node=\"134\"\u003eMAPK\/ERK pathway\u003c\/b\u003e. This expands the \"raw material\" needed for tissue repair before differentiation begins.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"22,1,0\"\u003e\u003cb data-path-to-node=\"22,1,0\" data-index-in-node=\"0\"\u003eNeuroprotection:\u003c\/b\u003e Protects motor neurons and hippocampal neurons from ischemia and degeneration by stabilizing mitochondrial function and inhibiting caspase-3.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"22,2,0\"\u003e\u003cb data-path-to-node=\"22,2,0\" data-index-in-node=\"0\"\u003eCardioprotection:\u003c\/b\u003e Reduces cardiomyocyte apoptosis and recruits cardiac progenitor cells to sites of infarction (heart attack).\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003chr data-path-to-node=\"23\"\u003e\n\u003ch3 data-path-to-node=\"24\"\u003e\u003cb data-path-to-node=\"24\" data-index-in-node=\"0\"\u003eKey Research Applications\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp data-path-to-node=\"25\"\u003e\u003cb data-path-to-node=\"25\" data-index-in-node=\"0\"\u003e1. Musculoskeletal Regeneration\u003c\/b\u003e MGF is the primary signal for muscle repair.\u003c\/p\u003e\n\u003cul data-path-to-node=\"26\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"26,0,0\"\u003e\u003cb data-path-to-node=\"26,0,0\" data-index-in-node=\"0\"\u003eHyperplasia:\u003c\/b\u003e Promotes the division of muscle cells (hyperplasia) rather than just size increase (hypertrophy).\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"26,1,0\"\u003e\u003cb data-path-to-node=\"26,1,0\" data-index-in-node=\"0\"\u003eSarcopenia:\u003c\/b\u003e Research suggests that the age-related loss of muscle is due to a failure to express MGF; exogenous MGF can restore the proliferative capacity of aged muscle stem cells.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp data-path-to-node=\"27\"\u003e\u003cb data-path-to-node=\"27\" data-index-in-node=\"0\"\u003e2. Neurodegenerative Disease (ALS)\u003c\/b\u003e In mouse models of ALS (SOD1), MGF gene therapy significantly improved motor neuron survival compared to IGF-1, protecting neurons from \"suicide transport\" mechanisms.\u003c\/p\u003e\n\u003cp data-path-to-node=\"28\"\u003e\u003cb data-path-to-node=\"28\" data-index-in-node=\"0\"\u003e3. Ischemia \u0026amp; Stroke\u003c\/b\u003e Investigated for its ability to rescue neurons from delayed death following stroke. In gerbil models of brain ischemia, MGF treatment resulted in \u003cb data-path-to-node=\"28\" data-index-in-node=\"167\"\u003e74.5% survival\u003c\/b\u003e of vulnerable hippocampal neurons compared to near-total loss in controls.\u003c\/p\u003e\n\u003chr data-path-to-node=\"29\"\u003e\n\u003ch3 data-path-to-node=\"30\"\u003e\u003cb data-path-to-node=\"30\" data-index-in-node=\"0\"\u003eImportant Note: MGF vs. PEG-MGF\u003c\/b\u003e\u003c\/h3\u003e\n\u003cul data-path-to-node=\"31\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"31,0,0\"\u003e\u003cb data-path-to-node=\"31,0,0\" data-index-in-node=\"0\"\u003eMGF (This Product):\u003c\/b\u003e Native sequence. Short half-life (~5-30 mins). Ideal for local administration mimicking the body's acute stress response.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"31,1,0\"\u003e\u003cb data-path-to-node=\"31,1,0\" data-index-in-node=\"0\"\u003ePEG-MGF:\u003c\/b\u003e PEGylated variant. Long half-life (days). Systemic distribution.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"31,2,0\"\u003e\u003ci data-path-to-node=\"31,2,0\" data-index-in-node=\"0\"\u003eThis listing is for the Native MGF peptide.\u003c\/i\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003chr data-path-to-node=\"32\"\u003e\n\u003ch3 data-path-to-node=\"33\"\u003e\u003cb data-path-to-node=\"33\" data-index-in-node=\"0\"\u003eStorage \u0026amp; Handling\u003c\/b\u003e\u003c\/h3\u003e\n\u003cul data-path-to-node=\"34\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"34,0,0\"\u003e\u003cb data-path-to-node=\"34,0,0\" data-index-in-node=\"0\"\u003ePhysical State:\u003c\/b\u003e Lyophilized (Freeze-Dried) White Powder.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"34,1,0\"\u003e\u003cb data-path-to-node=\"34,1,0\" data-index-in-node=\"0\"\u003eStorage (Powder):\u003c\/b\u003e Store at -20°C (Freezer). Stable for up to 12 months.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"34,2,0\"\u003e\u003cb data-path-to-node=\"34,2,0\" data-index-in-node=\"0\"\u003eReconstitution:\u003c\/b\u003e\u003c\/p\u003e\n\u003cul data-path-to-node=\"34,2,1\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"34,2,1,0,0\"\u003e\u003cb data-path-to-node=\"34,2,1,0,0\" data-index-in-node=\"0\"\u003eSolvent:\u003c\/b\u003e \u003cb data-path-to-node=\"34,2,1,0,0\" data-index-in-node=\"9\"\u003eSterile 0.1% Acetic Acid\u003c\/b\u003e is recommended to ensure full dissolution of basic residues, followed by dilution with sterile water or saline.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"34,2,1,1,0\"\u003e\u003cb data-path-to-node=\"34,2,1,1,0\" data-index-in-node=\"0\"\u003eStability:\u003c\/b\u003e Highly unstable once reconstituted. Use immediately or freeze single-use aliquots.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"34,3,0\"\u003e\u003cb data-path-to-node=\"34,3,0\" data-index-in-node=\"0\"\u003eStorage (Liquid):\u003c\/b\u003e Store at 4°C. \u003cb data-path-to-node=\"34,3,0\" data-index-in-node=\"32\"\u003eDo not freeze-thaw repeatedly.\u003c\/b\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003chr data-path-to-node=\"35\"\u003e\n\u003ch3 data-path-to-node=\"36\"\u003e\u003cb data-path-to-node=\"36\" data-index-in-node=\"0\"\u003eDisclaimer\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp data-path-to-node=\"37\"\u003e\u003cb data-path-to-node=\"37\" data-index-in-node=\"0\"\u003eFOR RESEARCH USE ONLY.\u003c\/b\u003e This product is a chemical compound intended strictly for laboratory research and development. It is not approved by the FDA for clinical use, diagnostics, or therapeutic procedures in humans or animals. The physiological and toxicological properties of this chemical have not been fully investigated.\u003c\/p\u003e","brand":"Peptagon","offers":[{"title":"Default Title","offer_id":47712362528982,"sku":"MGF-5","price":73.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0783\/3085\/5638\/files\/MGF-_IGF-1Ec_-5mg.png?v=1768509217","url":"https:\/\/peptagon.com\/products\/mgf-mechano-growth-factor-igf-1ec-research-peptide","provider":"Peptagon","version":"1.0","type":"link"}