{"product_id":"mots-c-mitochondrial-derived-research-peptide","title":"MOTS-c Research Peptide – 10mg","description":"\u003ch4 data-path-to-node=\"13\"\u003e\u003cstrong\u003eMOTS-c Peptide (Lyophilized)\u003c\/strong\u003e\u003c\/h4\u003e\n\u003cp data-path-to-node=\"14\"\u003e\u003cb data-path-to-node=\"14\" data-index-in-node=\"0\"\u003eSequence:\u003c\/b\u003e Met-Arg-Trp-Gln-Glu-Met-Gly-Tyr-Ile-Phe-Tyr-Pro-Arg-Lys-Leu-Arg \u003cb data-path-to-node=\"14\" data-index-in-node=\"74\"\u003eFormat:\u003c\/b\u003e Sterile Lyophilized Powder (Vial) \u003cb data-path-to-node=\"14\" data-index-in-node=\"116\"\u003eOrigin:\u003c\/b\u003e Mitochondrial-Derived Peptide (12S rRNA) \u003cb data-path-to-node=\"14\" data-index-in-node=\"165\"\u003ePurity:\u003c\/b\u003e \u0026gt;98% (HPLC) \u003cb data-path-to-node=\"14\" data-index-in-node=\"185\"\u003eContent:\u003c\/b\u003e 10mg per vial\u003c\/p\u003e\n\u003chr data-path-to-node=\"15\"\u003e\n\u003ch3 data-path-to-node=\"16\"\u003e\u003cb data-path-to-node=\"16\" data-index-in-node=\"0\"\u003eProduct Overview\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp data-path-to-node=\"17\"\u003e\u003cb data-path-to-node=\"17\" data-index-in-node=\"0\"\u003eMOTS-c\u003c\/b\u003e (Mitochondrial Open Reading Frame of the 12S rRNA-c) is a 16-amino acid peptide encoded within the mitochondrial genome. It represents a breakthrough in understanding how mitochondria communicate with the rest of the cell.\u003c\/p\u003e\n\u003cp data-path-to-node=\"18\"\u003eUnlike traditional hormones, MOTS-c acts as a \u003cb data-path-to-node=\"18\" data-index-in-node=\"46\"\u003emitochondrial signal\u003c\/b\u003e, translocating to the nucleus to regulate gene expression in response to metabolic stress. It is extensively researched for its ability to mimic the physiological effects of exercise, regulate insulin sensitivity, and promote healthy aging via the AMPK pathway.\u003c\/p\u003e\n\u003chr data-path-to-node=\"19\"\u003e\n\u003ch3 data-path-to-node=\"20\"\u003e\u003cb data-path-to-node=\"20\" data-index-in-node=\"0\"\u003eMechanism of Action: The Mitonuclear Signal\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp data-path-to-node=\"21\"\u003eMOTS-c functions via a unique dual mechanism involving metabolic enzyme inhibition and nuclear gene regulation.\u003c\/p\u003e\n\u003cul data-path-to-node=\"22\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"22,0,0\"\u003e\u003cb data-path-to-node=\"22,0,0\" data-index-in-node=\"0\"\u003eFolate-AMPK Axis:\u003c\/b\u003e It inhibits the enzyme ATIC in the folate cycle, leading to an accumulation of AICAR. This activates \u003cb data-path-to-node=\"22,0,0\" data-index-in-node=\"119\"\u003eAMPK\u003c\/b\u003e, the cell's master metabolic switch, driving fatty acid oxidation and glucose uptake without the need for insulin.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"22,1,0\"\u003e\u003cb data-path-to-node=\"22,1,0\" data-index-in-node=\"0\"\u003eNuclear Translocation:\u003c\/b\u003e Under stress, MOTS-c moves into the nucleus where it binds to \u003cb data-path-to-node=\"22,1,0\" data-index-in-node=\"85\"\u003eNRF2\u003c\/b\u003e and Antioxidant Response Elements (ARE), upregulating cytoprotective genes to defend against oxidative stress.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"22,2,0\"\u003e\u003cb data-path-to-node=\"22,2,0\" data-index-in-node=\"0\"\u003eMyostatin Inhibition:\u003c\/b\u003e Downregulates myostatin expression via the AKT-FOXO1 axis, preventing muscle atrophy.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003chr data-path-to-node=\"23\"\u003e\n\u003ch3 data-path-to-node=\"24\"\u003e\u003cb data-path-to-node=\"24\" data-index-in-node=\"0\"\u003eKey Research Applications\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp data-path-to-node=\"25\"\u003e\u003cb data-path-to-node=\"25\" data-index-in-node=\"0\"\u003e1. Metabolic Regulation (Obesity \u0026amp; Diabetes)\u003c\/b\u003e MOTS-c is a potent insulin sensitizer. In high-fat diet models, it prevents diet-induced obesity and reverses insulin resistance by promoting GLUT4 translocation and \"browning\" of white adipose tissue (thermogenesis).\u003c\/p\u003e\n\u003cp data-path-to-node=\"26\"\u003e\u003cb data-path-to-node=\"26\" data-index-in-node=\"0\"\u003e2. Exercise Mimicry \u0026amp; Performance\u003c\/b\u003e Known as an \"exercise mimetic,\" MOTS-c administration significantly improves physical performance. In aged mice, treatment \u003cb data-path-to-node=\"26\" data-index-in-node=\"157\"\u003edoubled running capacity\u003c\/b\u003e and improved grip strength, effectively rejuvenating skeletal muscle function.\u003c\/p\u003e\n\u003cp data-path-to-node=\"27\"\u003e\u003cb data-path-to-node=\"27\" data-index-in-node=\"0\"\u003e3. Gerontology (Anti-Aging)\u003c\/b\u003e Research (Reynolds et al.) indicates that late-life administration of MOTS-c can extend healthspan and lifespan. It restores the communication between mitochondria and the nucleus, which typically degrades with age, reducing frailty and metabolic decline.\u003c\/p\u003e\n\u003cp data-path-to-node=\"28\"\u003e\u003cb data-path-to-node=\"28\" data-index-in-node=\"0\"\u003e4. Osteobiology\u003c\/b\u003e Promotes bone formation (osteoblastogenesis) via the TGF-beta\/Smad pathway while inhibiting bone breakdown (osteoclasts), offering a potential avenue for osteoporosis research.\u003c\/p\u003e\n\u003chr data-path-to-node=\"29\"\u003e\n\u003ch3 data-path-to-node=\"30\"\u003e\u003cb data-path-to-node=\"30\" data-index-in-node=\"0\"\u003eStorage \u0026amp; Handling\u003c\/b\u003e\u003c\/h3\u003e\n\u003cul data-path-to-node=\"31\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"31,0,0\"\u003e\u003cb data-path-to-node=\"31,0,0\" data-index-in-node=\"0\"\u003ePhysical State:\u003c\/b\u003e Lyophilized (Freeze-Dried) White Powder.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"31,1,0\"\u003e\u003cb data-path-to-node=\"31,1,0\" data-index-in-node=\"0\"\u003eStorage (Powder):\u003c\/b\u003e Store at -20°C (Freezer). Stable for up to 24 months.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"31,2,0\"\u003e\u003cb data-path-to-node=\"31,2,0\" data-index-in-node=\"0\"\u003eReconstitution:\u003c\/b\u003e\u003c\/p\u003e\n\u003cul data-path-to-node=\"31,2,1\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"31,2,1,0,0\"\u003e\u003cb data-path-to-node=\"31,2,1,0,0\" data-index-in-node=\"0\"\u003eSolvent:\u003c\/b\u003e Sterile Water or Bacteriostatic Water.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"31,2,1,1,0\"\u003e\u003cb data-path-to-node=\"31,2,1,1,0\" data-index-in-node=\"0\"\u003eSolubility:\u003c\/b\u003e Soluble in water.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"31,3,0\"\u003e\u003cb data-path-to-node=\"31,3,0\" data-index-in-node=\"0\"\u003eStorage (Liquid):\u003c\/b\u003e Store at 4°C (Refrigerator). Use within 14 days. \u003cb data-path-to-node=\"31,3,0\" data-index-in-node=\"67\"\u003eDo not freeze-thaw repeatedly.\u003c\/b\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003chr data-path-to-node=\"32\"\u003e\n\u003ch3 data-path-to-node=\"33\"\u003e\u003cb data-path-to-node=\"33\" data-index-in-node=\"0\"\u003eDisclaimer\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp data-path-to-node=\"34\"\u003e\u003cb data-path-to-node=\"34\" data-index-in-node=\"0\"\u003eFOR RESEARCH USE ONLY.\u003c\/b\u003e This product is a chemical compound intended strictly for laboratory research and development. It is not approved by the FDA for clinical use, diagnostics, or therapeutic procedures in humans or animals. The physiological and toxicological properties of this chemical have not been fully investigated.\u003c\/p\u003e","brand":"Peptagon","offers":[{"title":"Default Title","offer_id":47712368034006,"sku":"MOTSC-10","price":36.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0783\/3085\/5638\/files\/MOTs-C-10mg.png?v=1768507596","url":"https:\/\/peptagon.com\/products\/mots-c-mitochondrial-derived-research-peptide","provider":"Peptagon","version":"1.0","type":"link"}