{"product_id":"nad-nicotinamide-adenine-dinucleotide-1000mg-research-vial","title":"NAD+ Research Vial – 1000mg – 5mL","description":"\u003ch4 data-path-to-node=\"13\"\u003e\u003cstrong\u003eNAD+ (Nicotinamide Adenine Dinucleotide) 1000mg\u003c\/strong\u003e\u003c\/h4\u003e\n\u003cp data-path-to-node=\"14\"\u003e\u003cb data-path-to-node=\"14\" data-index-in-node=\"0\"\u003eConcentration:\u003c\/b\u003e 200 mg\/mL (1000mg total in 5mL) \u003cb data-path-to-node=\"14\" data-index-in-node=\"47\"\u003eFormat:\u003c\/b\u003e Sterile Aqueous Solution (High-Load) \u003cb data-path-to-node=\"14\" data-index-in-node=\"92\"\u003eOrigin:\u003c\/b\u003e Biofermented (Yeast-Derived, Endotoxin-Free) \u003cb data-path-to-node=\"14\" data-index-in-node=\"145\"\u003ePurity:\u003c\/b\u003e \u0026gt;99% (Pharmaceutical Grade) \u003cb data-path-to-node=\"14\" data-index-in-node=\"181\"\u003epH:\u003c\/b\u003e Neutral-Buffered (Optimized for Stability)\u003cbr\u003e\u003c\/p\u003e\n\u003ch3 data-path-to-node=\"17\"\u003e\u003cb data-path-to-node=\"17\" data-index-in-node=\"0\"\u003eProduct Overview\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp data-path-to-node=\"18\"\u003e\u003cb data-path-to-node=\"18\" data-index-in-node=\"0\"\u003eNAD+ (Nicotinamide Adenine Dinucleotide)\u003c\/b\u003e is the central coenzyme of metabolism, essential for converting nutrients into energy (ATP). This \u003cb data-path-to-node=\"18\" data-index-in-node=\"139\"\u003e1000mg Biofermented Formulation\u003c\/b\u003e represents the pinnacle of solubility engineering, achieving a concentration of \u003cb data-path-to-node=\"18\" data-index-in-node=\"251\"\u003e200 mg\/mL\u003c\/b\u003e.\u003c\/p\u003e\n\u003cp data-path-to-node=\"19\"\u003eProduced via metabolic engineering of \u003ci data-path-to-node=\"19\" data-index-in-node=\"38\"\u003eSaccharomyces cerevisiae\u003c\/i\u003e, this formulation ensures stereochemical purity (active β-anomer only) and is rigorously purified to remove endotoxins (\u0026lt;0.35 EU\/mg). It is designed for high-dose research applications where \"flooding\" the metabolic salvage pathway is required to overcome rate-limiting enzymes.\u003c\/p\u003e\n\u003chr data-path-to-node=\"20\"\u003e\n\u003ch3 data-path-to-node=\"21\"\u003e\u003cb data-path-to-node=\"21\" data-index-in-node=\"0\"\u003eMechanism of Action: The Metabolic Master Switch\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp data-path-to-node=\"22\"\u003eNAD+ operates as both a metabolic cofactor and a signaling molecule.\u003c\/p\u003e\n\u003cul data-path-to-node=\"23\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"23,0,0\"\u003e\u003cb data-path-to-node=\"23,0,0\" data-index-in-node=\"0\"\u003eSirtuin Activation:\u003c\/b\u003e It is the obligatory substrate for Sirtuins (SIRT1-7), the \"longevity genes.\" High-dose NAD+ activates SIRT1, leading to the deacetylation of FOXO3a (stress resistance) and PGC-1alpha (mitochondrial biogenesis).\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"23,1,0\"\u003e\u003cb data-path-to-node=\"23,1,0\" data-index-in-node=\"0\"\u003eMitochondrial Rescue:\u003c\/b\u003e Reverses \"pseudohypoxia\" (the false signal of low oxygen) in aging cells, restoring mitochondrial ATP production and electron transport chain efficiency.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"23,2,0\"\u003e\u003cb data-path-to-node=\"23,2,0\" data-index-in-node=\"0\"\u003eNeuroprotection (SARM1):\u003c\/b\u003e Inhibits the enzyme SARM1. In injured axons, high levels of NAD+ prevent SARM1 activation, halting axon degeneration and preserving neural architecture.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003chr data-path-to-node=\"24\"\u003e\n\u003ch3 data-path-to-node=\"25\"\u003e\u003cb data-path-to-node=\"25\" data-index-in-node=\"0\"\u003eKey Research Applications\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp data-path-to-node=\"26\"\u003e\u003cb data-path-to-node=\"26\" data-index-in-node=\"0\"\u003e1. Addiction \u0026amp; Neurotransmitter Restoration\u003c\/b\u003e High-dose NAD+ is the cornerstone of \"Brain Restoration\" research. It replenishes mitochondrial energy in neurons and re-regulates the circadian clock (via SIRT1\/CLOCK), normalizing \u003cb data-path-to-node=\"26\" data-index-in-node=\"226\"\u003edopamine synthesis\u003c\/b\u003e in the nucleus accumbens to reduce cravings and withdrawal anxiety.\u003c\/p\u003e\n\u003cp data-path-to-node=\"27\"\u003e\u003cb data-path-to-node=\"27\" data-index-in-node=\"0\"\u003e2. Anti-Aging \u0026amp; Metabolic Health\u003c\/b\u003e Investigated for its ability to mimic caloric restriction. By activating AMPK and SIRT1, it corrects dyslipidemia, improves insulin sensitivity, and promotes healthy DNA repair via PARP enzymes.\u003c\/p\u003e\n\u003cp data-path-to-node=\"28\"\u003e\u003cb data-path-to-node=\"28\" data-index-in-node=\"0\"\u003e3. Ischemia \u0026amp; Cytoprotection\u003c\/b\u003e In models of heart attack (ischemia-reperfusion), NAD+ administration reduced infarct size by up to \u003cb data-path-to-node=\"28\" data-index-in-node=\"129\"\u003e85%\u003c\/b\u003e. It salvages tissue viability by maintaining ATP levels during critical stress.\u003c\/p\u003e\n\u003chr data-path-to-node=\"29\"\u003e\n\u003ch3 data-path-to-node=\"30\"\u003e\u003cb data-path-to-node=\"30\" data-index-in-node=\"0\"\u003eStorage \u0026amp; Handling\u003c\/b\u003e\u003c\/h3\u003e\n\u003cul data-path-to-node=\"31\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"31,0,0\"\u003e\u003cb data-path-to-node=\"31,0,0\" data-index-in-node=\"0\"\u003ePhysical State:\u003c\/b\u003e Clear to slightly yellow liquid.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"31,1,0\"\u003e\u003cb data-path-to-node=\"31,1,0\" data-index-in-node=\"0\"\u003eStorage:\u003c\/b\u003e \u003cb data-path-to-node=\"31,1,0\" data-index-in-node=\"9\"\u003eMUST BE REFRIGERATED (2-8°C).\u003c\/b\u003e Do not freeze.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"31,2,0\"\u003e\u003cb data-path-to-node=\"31,2,0\" data-index-in-node=\"0\"\u003eStability:\u003c\/b\u003e This high-concentration formulation is thermodynamically stable at cold temperatures. Room temperature storage will accelerate degradation into Nicotinamide (an inhibitor).\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003chr data-path-to-node=\"32\"\u003e\n\u003ch3 data-path-to-node=\"33\"\u003e\u003cb data-path-to-node=\"33\" data-index-in-node=\"0\"\u003eDisclaimer\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp data-path-to-node=\"34\"\u003e\u003cb data-path-to-node=\"34\" data-index-in-node=\"0\"\u003eFOR RESEARCH USE ONLY.\u003c\/b\u003e This product is a chemical compound intended strictly for laboratory research and development. It is not approved by the FDA for clinical use, diagnostics, or therapeutic procedures in humans or animals. The physiological and toxicological properties of this chemical have not been fully investigated.\u003c\/p\u003e","brand":"Peptagon","offers":[{"title":"Default Title","offer_id":47712407060694,"sku":"NAD-BF-1000","price":72.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0783\/3085\/5638\/files\/NAD.png?v=1776955277","url":"https:\/\/peptagon.com\/products\/nad-nicotinamide-adenine-dinucleotide-1000mg-research-vial","provider":"Peptagon","version":"1.0","type":"link"}