{"product_id":"pe-22-28-trek-1-research-peptide","title":"PE-22-28 Research Peptide – 10mg","description":"\u003ch4 data-path-to-node=\"13\"\u003e\u003cstrong\u003ePE-22-28 Peptide (Lyophilized)\u003c\/strong\u003e\u003c\/h4\u003e\n\u003cp data-path-to-node=\"14\"\u003e\u003cb data-path-to-node=\"14\" data-index-in-node=\"0\"\u003eSequence:\u003c\/b\u003e Gly-Val-Ser-Trp-Gly-Leu-Arg (GVSWGLR) \u003cb data-path-to-node=\"14\" data-index-in-node=\"48\"\u003eFormat:\u003c\/b\u003e Sterile Lyophilized Powder (Vial) \u003cb data-path-to-node=\"14\" data-index-in-node=\"90\"\u003eTarget:\u003c\/b\u003e TREK-1 Potassium Channel Inhibitor \u003cb data-path-to-node=\"14\" data-index-in-node=\"133\"\u003ePurity:\u003c\/b\u003e \u0026gt;98% (HPLC) \u003cb data-path-to-node=\"14\" data-index-in-node=\"153\"\u003eContent:\u003c\/b\u003e 10mg per vial\u003c\/p\u003e\n\u003chr data-path-to-node=\"15\"\u003e\n\u003ch3 data-path-to-node=\"16\"\u003e\u003cb data-path-to-node=\"16\" data-index-in-node=\"0\"\u003eProduct Overview\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp data-path-to-node=\"17\"\u003e\u003cb data-path-to-node=\"17\" data-index-in-node=\"0\"\u003ePE-22-28\u003c\/b\u003e is a synthetic heptapeptide derived from the endogenous protein Spadin (Sortilin). It is a highly potent inhibitor of the \u003cb data-path-to-node=\"17\" data-index-in-node=\"131\"\u003eTREK-1 (TWIK-related potassium channel-1)\u003c\/b\u003e ion channel.\u003c\/p\u003e\n\u003cp data-path-to-node=\"18\"\u003eUnlike traditional antidepressants that target serotonin reuptake (SSRIs), PE-22-28 works downstream by modulating neuronal excitability directly. It acts as a \"neuroplasticity catalyst,\" promoting the growth of new neurons (neurogenesis) and synapses (synaptogenesis) in the hippocampus and prefrontal cortex. It is investigated for its ability to produce rapid antidepressant effects in \u003cb data-path-to-node=\"18\" data-index-in-node=\"389\"\u003e4 days\u003c\/b\u003e, compared to the 3-4 weeks required for standard therapies.\u003c\/p\u003e\n\u003chr data-path-to-node=\"19\"\u003e\n\u003ch3 data-path-to-node=\"20\"\u003e\u003cb data-path-to-node=\"20\" data-index-in-node=\"0\"\u003eMechanism of Action: The TREK-1 Blockade\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp data-path-to-node=\"21\"\u003ePE-22-28 functions by blocking the background \"leak\" current of potassium ions in neurons.\u003c\/p\u003e\n\u003cul data-path-to-node=\"22\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"22,0,0\"\u003e\u003cb data-path-to-node=\"22,0,0\" data-index-in-node=\"0\"\u003eDepolarization:\u003c\/b\u003e By inhibiting TREK-1, it slightly depolarizes neurons, making them more excitable and ready to fire. This increases the activity of serotonergic neurons in the Dorsal Raphe Nucleus without the lag of autoreceptor desensitization.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"22,1,0\"\u003e\u003cb data-path-to-node=\"22,1,0\" data-index-in-node=\"0\"\u003eNeurotrophic Signaling:\u003c\/b\u003e The depolarization triggers calcium influx, activating the \u003cb data-path-to-node=\"22,1,0\" data-index-in-node=\"83\"\u003eCREB\u003c\/b\u003e transcription factor. This leads to the rapid expression of \u003cb data-path-to-node=\"22,1,0\" data-index-in-node=\"148\"\u003eBDNF (Brain-Derived Neurotrophic Factor)\u003c\/b\u003e, the key driver of neuronal growth and survival.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"22,2,0\"\u003e\u003cb data-path-to-node=\"22,2,0\" data-index-in-node=\"0\"\u003eSynaptogenesis:\u003c\/b\u003e Increases the density of \u003cb data-path-to-node=\"22,2,0\" data-index-in-node=\"41\"\u003ePSD-95\u003c\/b\u003e, a marker of mature, functional synapses, restoring connectivity in depressed or damaged brain circuits.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003chr data-path-to-node=\"23\"\u003e\n\u003ch3 data-path-to-node=\"24\"\u003e\u003cb data-path-to-node=\"24\" data-index-in-node=\"0\"\u003eKey Research Applications\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp data-path-to-node=\"25\"\u003e\u003cb data-path-to-node=\"25\" data-index-in-node=\"0\"\u003e1. Rapid-Acting Antidepressant\u003c\/b\u003e PE-22-28 is the benchmark for researching rapid mood recovery. Preclinical studies show it reduces immobility (depression-like behavior) and anxiety within \u003cb data-path-to-node=\"25\" data-index-in-node=\"187\"\u003e4 days\u003c\/b\u003e, offering a potential alternative to slow-acting monoaminergic drugs.\u003c\/p\u003e\n\u003cp data-path-to-node=\"26\"\u003e\u003cb data-path-to-node=\"26\" data-index-in-node=\"0\"\u003e2. Stroke Recovery \u0026amp; Neuroprotection\u003c\/b\u003e Investigated for its biphasic role in stroke:\u003c\/p\u003e\n\u003cul data-path-to-node=\"27\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"27,0,0\"\u003e\u003cb data-path-to-node=\"27,0,0\" data-index-in-node=\"0\"\u003eAcute Phase:\u003c\/b\u003e Low doses may offer neuroprotection.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"27,1,0\"\u003e\u003cb data-path-to-node=\"27,1,0\" data-index-in-node=\"0\"\u003eChronic Phase:\u003c\/b\u003e High doses stimulate neurogenesis, improving motor coordination and memory recovery weeks after ischemic injury.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp data-path-to-node=\"28\"\u003e\u003cb data-path-to-node=\"28\" data-index-in-node=\"0\"\u003e3. Cognitive Enhancement\u003c\/b\u003e By promoting synaptic plasticity and hippocampal neurogenesis, PE-22-28 is studied for its ability to improve spatial memory and learning capabilities in models of cognitive decline.\u003c\/p\u003e\n\u003chr data-path-to-node=\"29\"\u003e\n\u003ch3 data-path-to-node=\"30\"\u003e\u003cb data-path-to-node=\"30\" data-index-in-node=\"0\"\u003eStorage \u0026amp; Handling\u003c\/b\u003e\u003c\/h3\u003e\n\u003cul data-path-to-node=\"31\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"31,0,0\"\u003e\u003cb data-path-to-node=\"31,0,0\" data-index-in-node=\"0\"\u003ePhysical State:\u003c\/b\u003e Lyophilized (Freeze-Dried) White Powder.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"31,1,0\"\u003e\u003cb data-path-to-node=\"31,1,0\" data-index-in-node=\"0\"\u003eStorage (Powder):\u003c\/b\u003e Store at -20°C (Freezer). Stable for up to 24 months.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"31,2,0\"\u003e\u003cb data-path-to-node=\"31,2,0\" data-index-in-node=\"0\"\u003eReconstitution:\u003c\/b\u003e\u003c\/p\u003e\n\u003cul data-path-to-node=\"31,2,1\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"31,2,1,0,0\"\u003e\u003cb data-path-to-node=\"31,2,1,0,0\" data-index-in-node=\"0\"\u003eSolvent:\u003c\/b\u003e Sterile Water or Saline.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"31,2,1,1,0\"\u003e\u003cb data-path-to-node=\"31,2,1,1,0\" data-index-in-node=\"0\"\u003eSolubility:\u003c\/b\u003e Highly soluble.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"31,3,0\"\u003e\u003cb data-path-to-node=\"31,3,0\" data-index-in-node=\"0\"\u003eStorage (Liquid):\u003c\/b\u003e Store at 4°C (Refrigerator). Use within 14-21 days.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003chr data-path-to-node=\"32\"\u003e\n\u003ch3 data-path-to-node=\"33\"\u003e\u003cb data-path-to-node=\"33\" data-index-in-node=\"0\"\u003eDisclaimer\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp data-path-to-node=\"34\"\u003e\u003cb data-path-to-node=\"34\" data-index-in-node=\"0\"\u003eFOR RESEARCH USE ONLY.\u003c\/b\u003e This product is a chemical compound intended strictly for laboratory research and development. It is not approved by the FDA for clinical use, diagnostics, or therapeutic procedures in humans or animals. The physiological and toxicological properties of this chemical have not been fully investigated.\u003c\/p\u003e","brand":"Peptagon","offers":[{"title":"Default Title","offer_id":47712433406166,"sku":"PE2228-10","price":32.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0783\/3085\/5638\/files\/PE-22-28-10mmg.png?v=1768510335","url":"https:\/\/peptagon.com\/products\/pe-22-28-trek-1-research-peptide","provider":"Peptagon","version":"1.0","type":"link"}