{"product_id":"slu-pp-332-err-pan-agonist-research-tablets","title":"SLU-PP-332 Research Tablets – 250mcg \/ 1mg \/ 200mg – 60 Count","description":"\u003ch4 data-path-to-node=\"11\"\u003e\u003cstrong\u003eSLU-PP-332: The Mitochondrial Exercise Mimetic\u003c\/strong\u003e\u003c\/h4\u003e\n\u003cp data-path-to-node=\"12\"\u003e\u003cb data-path-to-node=\"12\" data-index-in-node=\"0\"\u003eChemical Name:\u003c\/b\u003e (E)-4-hydroxy-N'-(naphthalen-2-ylmethylene)benzohydrazide \u003cb data-path-to-node=\"12\" data-index-in-node=\"73\"\u003eFormat:\u003c\/b\u003e Oral Tablets \u003cb data-path-to-node=\"12\" data-index-in-node=\"94\"\u003eClass:\u003c\/b\u003e Estrogen-Related Receptor (ERR) Pan-Agonist \u003cb data-path-to-node=\"12\" data-index-in-node=\"145\"\u003ePurity:\u003c\/b\u003e ≥98% (HPLC) \u003cb data-path-to-node=\"12\" data-index-in-node=\"165\"\u003eTarget:\u003c\/b\u003e ERRα, ERRβ, and ERRγ Transcriptional Networks\u003c\/p\u003e\n\u003chr data-path-to-node=\"13\"\u003e\n\u003ch3 data-path-to-node=\"14\"\u003e\u003cb data-path-to-node=\"14\" data-index-in-node=\"0\"\u003eProduct Overview\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp data-path-to-node=\"15\"\u003e\u003cb data-path-to-node=\"15\" data-index-in-node=\"0\"\u003eSLU-PP-332\u003c\/b\u003e is a first-in-class small molecule designed to function as an \"exercise mimetic.\" Developed through a collaboration between Saint Louis University and Washington University, it acts as a potent pan-agonist of the \u003cb data-path-to-node=\"15\" data-index-in-node=\"224\"\u003eEstrogen-Related Receptor (ERR)\u003c\/b\u003e family.\u003c\/p\u003e\n\u003cp data-path-to-node=\"16\"\u003eUnlike standard weight-loss agents that target appetite, SLU-PP-332 operates directly on peripheral tissues. It induces a high-oxidative state in skeletal muscle, effectively \"tricking\" the body into simulating the systemic benefits of endurance training. It is a premier tool for researching the reversal of metabolic syndrome, obesity, and age-related physiological decline through direct transcriptional modulation.\u003c\/p\u003e\n\u003chr data-path-to-node=\"17\"\u003e\n\u003ch3 data-path-to-node=\"18\"\u003e\u003cb data-path-to-node=\"18\" data-index-in-node=\"0\"\u003eMechanism of Action: Transcriptional Fat Burning\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp data-path-to-node=\"19\"\u003eSLU-PP-332 bypasses mechanical work to activate the genetic programs associated with physical exertion.\u003c\/p\u003e\n\u003cul data-path-to-node=\"20\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"20,0,0\"\u003e\u003cb data-path-to-node=\"20,0,0\" data-index-in-node=\"0\"\u003eERR Activation:\u003c\/b\u003e Specifically targets \u003cb data-path-to-node=\"20,0,0\" data-index-in-node=\"37\"\u003eERRα\u003c\/b\u003e, the master regulator of mitochondrial biogenesis. It stabilizes the active conformation of the receptor, allowing for the recruitment of the co-activator \u003cb data-path-to-node=\"20,0,0\" data-index-in-node=\"197\"\u003ePGC-1α\u003c\/b\u003e.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"20,1,0\"\u003e\u003cb data-path-to-node=\"20,1,0\" data-index-in-node=\"0\"\u003eMitochondrial Overdrive:\u003c\/b\u003e Upregulates the \u003cb data-path-to-node=\"20,1,0\" data-index-in-node=\"41\"\u003ePdk4\u003c\/b\u003e gene, which switches cellular fuel preference from glucose to fatty acids. This results in a \u003cb data-path-to-node=\"20,1,0\" data-index-in-node=\"139\"\u003e2.5x increase in mitochondrial DNA\u003c\/b\u003e and enhanced ATP production within myocytes.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"20,2,0\"\u003e\u003cb data-path-to-node=\"20,2,0\" data-index-in-node=\"0\"\u003eTissue Remodeling:\u003c\/b\u003e Promotes the development of \u003cb data-path-to-node=\"20,2,0\" data-index-in-node=\"47\"\u003eType IIa oxidative muscle fibers\u003c\/b\u003e, which are highly resistant to fatigue.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"20,3,0\"\u003e\u003cb data-path-to-node=\"20,3,0\" data-index-in-node=\"0\"\u003eSTING Pathway Inhibition:\u003c\/b\u003e In aging models, it has been shown to shutdown the \u003cb data-path-to-node=\"20,3,0\" data-index-in-node=\"77\"\u003ecGAS-STING\u003c\/b\u003e inflammatory response, protecting vital organs like the kidneys from age-related decline.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003chr data-path-to-node=\"21\"\u003e\n\u003ch3 data-path-to-node=\"22\"\u003e\u003cb data-path-to-node=\"22\" data-index-in-node=\"0\"\u003eKey Research Applications\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp data-path-to-node=\"23\"\u003e\u003cb data-path-to-node=\"23\" data-index-in-node=\"0\"\u003e1. Endurance \u0026amp; Physical Performance\u003c\/b\u003e Investigated for its ability to dramatically enhance aerobic capacity. In animal models, subjects treated with SLU-PP-332 were able to run \u003cb data-path-to-node=\"23\" data-index-in-node=\"175\"\u003e70% longer and 45% further\u003c\/b\u003e on treadmill tests compared to controls, despite no increase in actual physical activity.\u003c\/p\u003e\n\u003cp data-path-to-node=\"24\"\u003e\u003cb data-path-to-node=\"24\" data-index-in-node=\"0\"\u003e2. Obesity \u0026amp; Metabolic Syndrome\u003c\/b\u003e Research in Diet-Induced Obesity (DIO) models shows a \u003cb data-path-to-node=\"24\" data-index-in-node=\"86\"\u003e12% reduction in total body weight\u003c\/b\u003e and a 10-fold reduction in fat accumulation. The weight loss is driven by a ~25% increase in whole-body fat oxidation and resting energy expenditure.\u003c\/p\u003e\n\u003cp data-path-to-node=\"25\"\u003e\u003cb data-path-to-node=\"25\" data-index-in-node=\"0\"\u003e3. Geroprotection (Kidney \u0026amp; Muscle)\u003c\/b\u003e Studies in aged mice demonstrate that SLU-PP-332 reverses podocyte loss in the kidney and reduces albuminuria. It also promotes human myotube formation and fiber diameter, offering a model for treating \u003cb data-path-to-node=\"25\" data-index-in-node=\"238\"\u003esarcopenia\u003c\/b\u003e and muscle atrophy.\u003c\/p\u003e\n\u003cp data-path-to-node=\"26\"\u003e\u003cb data-path-to-node=\"26\" data-index-in-node=\"0\"\u003e4. Cardiovascular Support\u003c\/b\u003e Investigated for its ability to improve ejection fraction and survival rates in models of heart failure by normalizing oxidative phosphorylation profiles without inducing pathological hypertrophy.\u003c\/p\u003e\n\u003chr data-path-to-node=\"27\"\u003e\n\u003ch3 data-path-to-node=\"28\"\u003e\u003cb data-path-to-node=\"28\" data-index-in-node=\"0\"\u003eStorage \u0026amp; Handling\u003c\/b\u003e\u003c\/h3\u003e\n\u003cul data-path-to-node=\"29\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"29,0,0\"\u003e\u003cb data-path-to-node=\"29,0,0\" data-index-in-node=\"0\"\u003ePhysical State:\u003c\/b\u003e Standardized oral tablets for precise experimental protocols.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"29,1,0\"\u003e\u003cb data-path-to-node=\"29,1,0\" data-index-in-node=\"0\"\u003eStorage:\u003c\/b\u003e Store in a cool, dry place away from direct light.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"29,2,0\"\u003e\u003cb data-path-to-node=\"29,2,0\" data-index-in-node=\"0\"\u003eLong-Term Storage:\u003c\/b\u003e Store at -20°C (Freezer) to maintain stability for up to 4 years.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"29,3,0\"\u003e\u003cb data-path-to-node=\"29,3,0\" data-index-in-node=\"0\"\u003eStability:\u003c\/b\u003e Highly stable in tablet form; the lyophilized powder is resistant to degradation at room temperature for up to 3 weeks during transit.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003chr data-path-to-node=\"30\"\u003e\n\u003ch3 data-path-to-node=\"31\"\u003e\u003cb data-path-to-node=\"31\" data-index-in-node=\"0\"\u003eDisclaimer\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp data-path-to-node=\"32\"\u003e\u003cb data-path-to-node=\"32\" data-index-in-node=\"0\"\u003eFOR RESEARCH USE ONLY.\u003c\/b\u003e This product is a chemical compound intended strictly for laboratory research and development. It is not approved by the FDA for clinical use, diagnostics, or therapeutic procedures in humans or animals. The physiological and toxicological properties of this chemical have not been fully investigated.\u003c\/p\u003e","brand":"Peptagon","offers":[{"title":"250mcg","offer_id":47712730317014,"sku":"SLU-250x60","price":47.0,"currency_code":"USD","in_stock":true},{"title":"1mg","offer_id":47712730349782,"sku":"SLU-1x60","price":70.0,"currency_code":"USD","in_stock":true},{"title":"200mg","offer_id":48153996853462,"sku":"SLU-200x60","price":47.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0783\/3085\/5638\/files\/SLU-PP-332-_250mcg_-x-60-Tablets.png?v=1768837142","url":"https:\/\/peptagon.com\/products\/slu-pp-332-err-pan-agonist-research-tablets","provider":"Peptagon","version":"1.0","type":"link"}