{"product_id":"tb-500-thymosin-beta-4-research-peptide","title":"Thymosin Beta 4 Research Peptide – 10mg","description":"\u003ch4 data-path-to-node=\"13\"\u003e\u003cstrong\u003eTB-500 Peptide (Lyophilized)\u003c\/strong\u003e\u003c\/h4\u003e\n\u003cp data-path-to-node=\"14\"\u003e\u003cb data-path-to-node=\"14\" data-index-in-node=\"0\"\u003eSequence:\u003c\/b\u003e Ac-Ser-Asp-Lys-Pro-Asp-Met-Ala-Glu-Ile-Glu-Lys-Phe-Asp-Lys-Ser-Lys-Leu-Lys-Lys-Thr-Glu-Thr-Gln-Glu-Lys-Asn-Pro-Leu-Pro-Ser-Lys-Glu-Thr-Ile-Glu-Gln-Glu-Lys-Gln-Ala-Gly-Glu-Ser-OH \u003cb data-path-to-node=\"14\" data-index-in-node=\"188\"\u003eFormat:\u003c\/b\u003e Sterile Lyophilized Powder (Vial) \u003cb data-path-to-node=\"14\" data-index-in-node=\"230\"\u003eClass:\u003c\/b\u003e G-Actin Sequestering Peptide \u003cb data-path-to-node=\"14\" data-index-in-node=\"266\"\u003ePurity:\u003c\/b\u003e \u0026gt;98% (HPLC) \u003cb data-path-to-node=\"14\" data-index-in-node=\"286\"\u003eContent:\u003c\/b\u003e 5mg or 10mg per vial\u003c\/p\u003e\n\u003chr data-path-to-node=\"15\"\u003e\n\u003ch3 data-path-to-node=\"16\"\u003e\u003cb data-path-to-node=\"16\" data-index-in-node=\"0\"\u003eProduct Overview\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp data-path-to-node=\"17\"\u003e\u003cb data-path-to-node=\"17\" data-index-in-node=\"0\"\u003eTB-500\u003c\/b\u003e is a synthetic version of the naturally occurring peptide \u003cb data-path-to-node=\"17\" data-index-in-node=\"65\"\u003eThymosin Beta-4 (Tβ4)\u003c\/b\u003e. Found in high concentrations in almost all tissue types, Tβ4 is the primary molecule responsible for regulating cytoskeletal dynamics via G-actin sequestration.\u003c\/p\u003e\n\u003cp data-path-to-node=\"18\"\u003eTB-500 is widely researched for its potent regenerative capabilities. By maintaining the pool of actin monomers required for cell motility, it facilitates rapid tissue repair, angiogenesis (new blood vessel formation), and the modulation of inflammation in skin, heart, and neural tissues.\u003c\/p\u003e\n\u003chr data-path-to-node=\"19\"\u003e\n\u003ch3 data-path-to-node=\"20\"\u003e\u003cb data-path-to-node=\"20\" data-index-in-node=\"0\"\u003eMechanism of Action: The Cellular Architect\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp data-path-to-node=\"21\"\u003eTB-500 operates through distinct intracellular and extracellular pathways to drive regeneration.\u003c\/p\u003e\n\u003cul data-path-to-node=\"22\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"22,0,0\"\u003e\u003cb data-path-to-node=\"22,0,0\" data-index-in-node=\"0\"\u003eG-Actin Sequestration:\u003c\/b\u003e The peptide contains a conserved \u003cb data-path-to-node=\"22,0,0\" data-index-in-node=\"56\"\u003eLKKTET\u003c\/b\u003e motif that binds to G-actin (monomeric actin). This prevents premature polymerization, maintaining a \"ready pool\" of actin monomers essential for rapid cell migration and wound closure.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"22,1,0\"\u003e\u003cb data-path-to-node=\"22,1,0\" data-index-in-node=\"0\"\u003eNotch \u0026amp; VEGF Signaling:\u003c\/b\u003e Upregulates \u003cb data-path-to-node=\"22,1,0\" data-index-in-node=\"36\"\u003eNotch1\u003c\/b\u003e and \u003cb data-path-to-node=\"22,1,0\" data-index-in-node=\"47\"\u003eHIF-1α\u003c\/b\u003e, promoting angiogenesis and vascular repair, particularly under hypoxic (low oxygen) conditions.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"22,2,0\"\u003e\u003cb data-path-to-node=\"22,2,0\" data-index-in-node=\"0\"\u003eInflammation Control:\u003c\/b\u003e Inhibits the \u003cb data-path-to-node=\"22,2,0\" data-index-in-node=\"35\"\u003eNF-κB pathway\u003c\/b\u003e, reducing the expression of pro-inflammatory cytokines like IL-8 and promoting the transition of macrophages to a pro-repair (M2) phenotype.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003chr data-path-to-node=\"23\"\u003e\n\u003ch3 data-path-to-node=\"24\"\u003e\u003cb data-path-to-node=\"24\" data-index-in-node=\"0\"\u003eKey Research Applications\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp data-path-to-node=\"25\"\u003e\u003cb data-path-to-node=\"25\" data-index-in-node=\"0\"\u003e1. Dermal Wound Healing\u003c\/b\u003e TB-500 significantly accelerates wound closure. Research in rat models demonstrates a \u003cb data-path-to-node=\"25\" data-index-in-node=\"110\"\u003e42% improvement in re-epithelialization\u003c\/b\u003e by day 4 and improved collagen organization, reducing scarring.\u003c\/p\u003e\n\u003cp data-path-to-node=\"26\"\u003e\u003cb data-path-to-node=\"26\" data-index-in-node=\"0\"\u003e2. Cardiovascular Regeneration\u003c\/b\u003e In models of myocardial infarction (heart attack), TB-500 administration reduces cardiac rupture and inflammatory infiltration. It reactivates embryonic coronary development programs, promoting the growth of new blood vessels in damaged heart tissue.\u003c\/p\u003e\n\u003cp data-path-to-node=\"27\"\u003e\u003cb data-path-to-node=\"27\" data-index-in-node=\"0\"\u003e3. Neuroprotection \u0026amp; Remyelination\u003c\/b\u003e Investigated for its ability to mobilize Oligodendrocyte Progenitor Cells (OPCs) in the brain. Studies show it can enhance functional recovery in models of demyelination and neurotrauma.\u003c\/p\u003e\n\u003chr data-path-to-node=\"28\"\u003e\n\u003ch3 data-path-to-node=\"29\"\u003e\u003cb data-path-to-node=\"29\" data-index-in-node=\"0\"\u003eStorage \u0026amp; Handling\u003c\/b\u003e\u003c\/h3\u003e\n\u003cul data-path-to-node=\"30\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"30,0,0\"\u003e\u003cb data-path-to-node=\"30,0,0\" data-index-in-node=\"0\"\u003ePhysical State:\u003c\/b\u003e Lyophilized (Freeze-Dried) White Powder.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"30,1,0\"\u003e\u003cb data-path-to-node=\"30,1,0\" data-index-in-node=\"0\"\u003eStorage (Powder):\u003c\/b\u003e Store at -20°C (Freezer). Stable for up to 3 weeks at room temperature, but long-term freezer storage is required.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"30,2,0\"\u003e\u003cb data-path-to-node=\"30,2,0\" data-index-in-node=\"0\"\u003eReconstitution:\u003c\/b\u003e\u003c\/p\u003e\n\u003cul data-path-to-node=\"30,2,1\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"30,2,1,0,0\"\u003e\u003cb data-path-to-node=\"30,2,1,0,0\" data-index-in-node=\"0\"\u003eSolvent:\u003c\/b\u003e Bacteriostatic Water (0.9% Benzyl Alcohol).\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"30,2,1,1,0\"\u003e\u003cb data-path-to-node=\"30,2,1,1,0\" data-index-in-node=\"0\"\u003eSolubility:\u003c\/b\u003e Highly soluble due to high glutamate\/lysine content.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"30,3,0\"\u003e\u003cb data-path-to-node=\"30,3,0\" data-index-in-node=\"0\"\u003eStorage (Liquid):\u003c\/b\u003e Store at 4°C (Refrigerator). \u003cb data-path-to-node=\"30,3,0\" data-index-in-node=\"47\"\u003eUse within 2-7 days.\u003c\/b\u003e\u003c\/p\u003e\n\u003cul data-path-to-node=\"30,3,1\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"30,3,1,0,0\"\u003e\u003ci data-path-to-node=\"30,3,1,0,0\" data-index-in-node=\"0\"\u003eNote:\u003c\/i\u003e For longer storage of reconstituted peptide, the addition of a carrier protein (0.1% HSA or BSA) is recommended to prevent degradation.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003chr data-path-to-node=\"31\"\u003e\n\u003ch3 data-path-to-node=\"32\"\u003e\u003cb data-path-to-node=\"32\" data-index-in-node=\"0\"\u003eDisclaimer\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp data-path-to-node=\"33\"\u003e\u003cb data-path-to-node=\"33\" data-index-in-node=\"0\"\u003eFOR RESEARCH USE ONLY.\u003c\/b\u003e This product is a chemical compound intended strictly for laboratory research and development. It is not approved by the FDA for clinical use, diagnostics, or therapeutic procedures in humans or animals. The physiological and toxicological properties of this chemical have not been fully investigated.\u003c\/p\u003e","brand":"Peptagon","offers":[{"title":"10mg","offer_id":47712656359638,"sku":"TB500-10","price":41.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0783\/3085\/5638\/files\/Thymosin-Beta-4-10mg_1.png?v=1778247602","url":"https:\/\/peptagon.com\/products\/tb-500-thymosin-beta-4-research-peptide","provider":"Peptagon","version":"1.0","type":"link"}