{"product_id":"tesofensine-ns2330-500mcg-research-tablets","title":"Tesofensine Research Tablets – 500mcg – 30 Count \/ 100 Count","description":"\u003ch4 data-path-to-node=\"11\"\u003e\u003cstrong\u003eTesofensine: The Triple Monoamine Modulator\u003c\/strong\u003e\u003c\/h4\u003e\n\u003cp data-path-to-node=\"12\"\u003e\u003cb data-path-to-node=\"12\" data-index-in-node=\"0\"\u003eChemical Name:\u003c\/b\u003e (1R,2R,3S,5S)-3-(3,4-dichlorophenyl)-2-(ethoxymethyl)-8-methyl-8-azabicyclo[3.2.1]octane \u003cb data-path-to-node=\"12\" data-index-in-node=\"104\"\u003eFormat:\u003c\/b\u003e Oral Tablets \u003cb data-path-to-node=\"12\" data-index-in-node=\"125\"\u003eClass:\u003c\/b\u003e SNDRI (Serotonin-Norepinephrine-Dopamine Reuptake Inhibitor) \u003cb data-path-to-node=\"12\" data-index-in-node=\"193\"\u003ePurity:\u003c\/b\u003e ≥99% (HPLC) \u003cb data-path-to-node=\"12\" data-index-in-node=\"213\"\u003eHalf-Life:\u003c\/b\u003e ~9 Days (Systemic)\u003c\/p\u003e\n\u003chr data-path-to-node=\"13\"\u003e\n\u003ch3 data-path-to-node=\"14\"\u003e\u003cb data-path-to-node=\"14\" data-index-in-node=\"0\"\u003eProduct Overview\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp data-path-to-node=\"15\"\u003e\u003cb data-path-to-node=\"15\" data-index-in-node=\"0\"\u003eTesofensine (NS2330)\u003c\/b\u003e is a novel, centrally acting triple monoamine reuptake inhibitor. Originally investigated for neurodegenerative conditions like Parkinson’s and Alzheimer’s, it was repurposed for metabolic research due to its profound effects on weight management and appetite suppression.\u003c\/p\u003e\n\u003cp data-path-to-node=\"16\"\u003eUnlike earlier agents that targeted only one or two neurotransmitters, Tesofensine simultaneously elevates \u003cb data-path-to-node=\"16\" data-index-in-node=\"107\"\u003eSerotonin, Norepinephrine, and Dopamine\u003c\/b\u003e in the synaptic cleft. This triple-action mechanism addresses the three pillars of metabolic optimization: increasing satiety, reducing food-seeking behavior, and enhancing the resting metabolic rate.\u003c\/p\u003e\n\u003chr data-path-to-node=\"17\"\u003e\n\u003ch3 data-path-to-node=\"18\"\u003e\u003cb data-path-to-node=\"18\" data-index-in-node=\"0\"\u003eMechanism of Action: Central Satiety \u0026amp; Thermogenesis\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp data-path-to-node=\"19\"\u003eTesofensine operates by modulating the chemical signals of hunger and energy expenditure in the brain.\u003c\/p\u003e\n\u003cul data-path-to-node=\"20\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"20,0,0\"\u003e\u003cb data-path-to-node=\"20,0,0\" data-index-in-node=\"0\"\u003eTriple Reuptake Inhibition:\u003c\/b\u003e Blocks the transporters for Serotonin (SERT), Norepinephrine (NET), and Dopamine (DAT).\u003c\/p\u003e\n\u003cul data-path-to-node=\"20,0,1\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"20,0,1,0,0\"\u003e\u003cb data-path-to-node=\"20,0,1,0,0\" data-index-in-node=\"0\"\u003eSerotonin:\u003c\/b\u003e Increases feelings of fullness and satiety via POMC neurons.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"20,0,1,1,0\"\u003e\u003cb data-path-to-node=\"20,0,1,1,0\" data-index-in-node=\"0\"\u003eNorepinephrine:\u003c\/b\u003e Stimulates adrenergic pathways to increase metabolic expenditure and fat oxidation.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"20,0,1,2,0\"\u003e\u003cb data-path-to-node=\"20,0,1,2,0\" data-index-in-node=\"0\"\u003eDopamine:\u003c\/b\u003e Normalizes reward circuitry, reducing the psychological drive for \"hedonic\" or compulsive eating.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"20,1,0\"\u003e\u003cb data-path-to-node=\"20,1,0\" data-index-in-node=\"0\"\u003eHypothalamic Silencing:\u003c\/b\u003e Research indicates that Tesofensine inhibits GABAergic neurons in the lateral hypothalamus (LH). Silencing these specific neurons reduces the initiation of feeding behaviors.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"20,2,0\"\u003e\u003cb data-path-to-node=\"20,2,0\" data-index-in-node=\"0\"\u003eNeurotrophic Support:\u003c\/b\u003e Chronic treatment has been shown to increase levels of \u003cb data-path-to-node=\"20,2,0\" data-index-in-node=\"77\"\u003eBrain-Derived Neurotrophic Factor (BDNF)\u003c\/b\u003e. This may help \"reset\" the biological body weight set-point and prevent the weight rebound common after caloric restriction.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003chr data-path-to-node=\"21\"\u003e\n\u003ch3 data-path-to-node=\"22\"\u003e\u003cb data-path-to-node=\"22\" data-index-in-node=\"0\"\u003eKey Research Applications\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp data-path-to-node=\"23\"\u003e\u003cb data-path-to-node=\"23\" data-index-in-node=\"0\"\u003e1. Clinical Obesity \u0026amp; Weight Loss\u003c\/b\u003e In Phase II trials (TIPO-1), the 500 mcg dose achieved a \u003cb data-path-to-node=\"23\" data-index-in-node=\"91\"\u003e9.2% weight loss\u003c\/b\u003e over 24 weeks—approximately double the efficacy of many traditional agents. Research focuses on its ability to target visceral and abdominal fat specifically.\u003c\/p\u003e\n\u003cp data-path-to-node=\"24\"\u003e\u003cb data-path-to-node=\"24\" data-index-in-node=\"0\"\u003e2. Metabolic Rate \u0026amp; Fat Oxidation\u003c\/b\u003e Investigated for its ability to increase resting energy expenditure. Respiration chamber studies show that Tesofensine can increase 24-hour fat oxidation by \u003cb data-path-to-node=\"24\" data-index-in-node=\"191\"\u003e18 grams\u003c\/b\u003e and boost nocturnal energy expenditure by \u003cb data-path-to-node=\"24\" data-index-in-node=\"242\"\u003e4.6%\u003c\/b\u003e.\u003c\/p\u003e\n\u003cp data-path-to-node=\"25\"\u003e\u003cb data-path-to-node=\"25\" data-index-in-node=\"0\"\u003e3. Hypothalamic Obesity \u0026amp; Rare Disorders\u003c\/b\u003e Studied for its potential in treating resistant forms of obesity, such as Prader-Willi Syndrome and hypothalamic obesity, where the brain’s hunger-regulating centers are fundamentally impaired.\u003c\/p\u003e\n\u003chr data-path-to-node=\"26\"\u003e\n\u003ch3 data-path-to-node=\"27\"\u003e\u003cb data-path-to-node=\"27\" data-index-in-node=\"0\"\u003eStorage \u0026amp; Handling\u003c\/b\u003e\u003c\/h3\u003e\n\u003cul data-path-to-node=\"28\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"28,0,0\"\u003e\u003cb data-path-to-node=\"28,0,0\" data-index-in-node=\"0\"\u003ePhysical State:\u003c\/b\u003e Oral tablets for precise research dosing.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"28,1,0\"\u003e\u003cb data-path-to-node=\"28,1,0\" data-index-in-node=\"0\"\u003eStorage:\u003c\/b\u003e Store in a cool, dry place.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"28,2,0\"\u003e\u003cb data-path-to-node=\"28,2,0\" data-index-in-node=\"0\"\u003eLong-Term Storage:\u003c\/b\u003e Store at -20°C (Freezer) to maintain maximum chemical stability.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"28,3,0\"\u003e\u003cb data-path-to-node=\"28,3,0\" data-index-in-node=\"0\"\u003eStability:\u003c\/b\u003e Highly lipophilic and stable at room temperature; however, it should be protected from light and moisture to prevent dealkylation.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003chr data-path-to-node=\"29\"\u003e\n\u003ch3 data-path-to-node=\"30\"\u003e\u003cb data-path-to-node=\"30\" data-index-in-node=\"0\"\u003eDisclaimer\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp data-path-to-node=\"31\"\u003e\u003cb data-path-to-node=\"31\" data-index-in-node=\"0\"\u003eFOR RESEARCH USE ONLY.\u003c\/b\u003e This product is a chemical compound intended strictly for laboratory research and development. It is not approved by the FDA for clinical use, diagnostics, or therapeutic procedures in humans or animals. The physiological and toxicological properties of this chemical have not been fully investigated.\u003c\/p\u003e","brand":"Peptagon","offers":[{"title":"30 Capsules","offer_id":47714815181014,"sku":"TESOF-500x30","price":165.0,"currency_code":"USD","in_stock":true},{"title":"100 Capsules","offer_id":47714815148246,"sku":"TESOF-500x100","price":413.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0783\/3085\/5638\/files\/Tesofensine-_500mcg_-x30Capsules.png?v=1778506379","url":"https:\/\/peptagon.com\/products\/tesofensine-ns2330-500mcg-research-tablets","provider":"Peptagon","version":"1.0","type":"link"}