5-Amino-1MQ (Selective NNMT Inhibitor)

5-Amino-1-methylquinolinium (5-Amino-1MQ)

Core Molecule: 5-amino-1-methylquinolin-1-ium Format: Oral Tablets Mechanism: Selective Nicotinamide N-methyltransferase (NNMT) Inhibitor Purity: ≥98% (HPLC) Salt Form: Iodide or Chloride

Product Overview

5-Amino-1MQ is a first-in-class small molecule inhibitor designed to target Nicotinamide N-methyltransferase (NNMT), a cytosolic enzyme that acts as a master regulator of the cellular "metabolic drain."

In states of obesity and aging, NNMT is often overexpressed, leading to the excessive methylation and excretion of nicotinamide. By inhibiting this enzyme, 5-Amino-1MQ prevents the loss of these precursors, effectively redirecting them into the NAD+ salvage pathway. This results in elevated intracellular NAD+ levels, optimized mitochondrial function, and enhanced energy metabolism without affecting appetite or caloric intake.

Mechanism of Action: The NAD+ Preservation

5-Amino-1MQ works by precisely blocking the catalytic pocket of the NNMT enzyme.

• Metabolic Rewiring: By stopping the conversion of nicotinamide (NAM) into 1-methylnicotinamide (1-MNA), the cell is forced to recycle NAM into NAD+. This increases the activity of sirtuins (SIRT1) and PARPs, which are essential for DNA repair and longevity.

• Lipogenesis Inhibition: In adipose tissue, NNMT inhibition reduces lipid accumulation by up to 70% (in vitro), shifting the cell's priority from fat storage to energy expenditure.

• Muscle Stem Cell Rescue: It has been shown to rejuvenate senescent muscle stem cells (muSCs), restoring the regenerative capacity of aged skeletal muscle and significantly increasing grip strength and torque in animal models.

Key Research Applications

1. Metabolic Syndrome & Obesity 5-Amino-1MQ is a primary candidate for researching weight loss that is independent of the central nervous system. In diet-induced obese models, it produced a 7-10% reduction in body weight in just 11 days by increasing the basal metabolic rate.

2. Muscle Regeneration & Sarcopenia Investigated for its ability to reverse age-related muscle decline. Research demonstrates a 70% increase in peak torque and a significant acceleration in healing following muscle injury in aged subjects.

3. NAD+ Synergy Because it "plugs the leak" of NAD+ precursors, 5-Amino-1MQ is frequently studied in combination with NAD+ boosters like NMN or NR to maximize cellular energy and mitochondrial health.

4. Autoimmune Inflammation Emerging research in conditions like Graves' orbitopathy shows that 5-Amino-1MQ can significantly reduce the production of pro-inflammatory cytokines (IL-6, IL-8) and suppress pathogenic tissue remodeling.

Storage & Handling

• Physical State: Tablet form for precise experimental dosing.

• Storage: Store in a cool, dry place. Long-term storage at -20°C is recommended to maintain maximum purity.

• Stability: Chemically stable at room temperature when protected from direct light and moisture.

Disclaimer

FOR RESEARCH USE ONLY. This product is a chemical compound intended strictly for laboratory research and development. It is not approved by the FDA for clinical use, diagnostics, or therapeutic procedures in humans or animals. The physiological and toxicological properties of this chemical have not been fully investigated.