Ipamorelin Peptide (10mg)

Ipamorelin Peptide (Lyophilized)

Sequence: Aib-His-D-2-Nal-D-Phe-Lys-NH2 Format: Sterile Lyophilized Powder (Vial) Class: Selective Growth Hormone Secretagogue (GHS) Purity: >98% (HPLC) Content: 5mg per vial

Product Overview

Ipamorelin is a third-generation synthetic pentapeptide and a highly selective agonist of the Ghrelin Receptor (GHS-R1a). It is distinguished from earlier secretagogues (like GHRP-6 and GHRP-2) by its exquisite selectivity.

While promoting a potent pulsatile release of Growth Hormone (GH), Ipamorelin is unique in that it does not stimulate ACTH, Cortisol, or Prolactin, even at high doses. This "clean" pharmacological profile makes it the preferred reagent for research requiring pure anabolic signaling without the "endocrine noise" of stress hormones.

Mechanism of Action: The Selective Pulse

Ipamorelin operates via the GHS-R1a receptor, initiating a cascade that mimics the body's natural growth hormone pulse.

• Selective GHS-R1a Activation: Binds to pituitary receptors, triggering the Gq/11-PLC-IP3 pathway. This mobilizes intracellular calcium to release GH vesicles.

• No Stress Hormone Spike: Unlike GHRPs, it avoids cross-reactivity with receptors that trigger cortisol or prolactin, preventing catabolic side effects.

• Anabolic Signaling: The released GH stimulates the liver to produce IGF-1, which activates the mTORC1 pathway in muscle (protein synthesis) and the Runx2 pathway in bone (osteoblast differentiation).

Key Research Applications

1. Musculoskeletal Growth & Recovery Ipamorelin is the gold standard for pure anabolic research.

• Hypertrophy: Drives muscle protein synthesis via mTOR activation without cortisol-induced muscle wasting.

• Bone Density: Studies (Johansen et al.) show it increases Longitudinal Bone Growth Rate (LGR) and bone mineral content by stimulating osteoblasts, even counteracting glucocorticoid-induced bone loss.

2. Metabolic Regulation & Body Composition

• Lipolysis: Promotes fat loss by increasing metabolic rate and fatty acid oxidation.

• Nitrogen Balance: Improves whole-body nitrogen retention by downregulating urea cycle enzymes in the liver, preserving amino acids for tissue repair.

3. Gastrointestinal Motility

• Postoperative Ileus: Accelerates gastric emptying and reverses bowel paralysis (ileus) following surgery via cholinergic pathways in the gut, aiding recovery.

Storage & Handling

• Physical State: Lyophilized (Freeze-Dried) White Powder.

• Storage (Powder): Store at -20°C (Freezer). Stable for up to 36 months.

• Reconstitution:

  • Solvent: Bacteriostatic Water or Sterile Saline.

  • Solubility: Highly soluble.

• Storage (Liquid): Store at 4°C (Refrigerator).

Disclaimer

FOR RESEARCH USE ONLY. This product is a chemical compound intended strictly for laboratory research and development. It is not approved by the FDA for clinical use, diagnostics, or therapeutic procedures in humans or animals. The physiological and toxicological properties of this chemical have not been fully investigated.