PEG MGF (Pegylated Mechano Growth Factor) (5mg)

PEG MGF Peptide (Lyophilized)

Sequence: PEG-Suc-Tyr-Gln-Pro-Pro-Ser-Thr-Asn-Lys-Asn-Thr-Lys-Ser-Gln-Arg-Arg-Lys-Gly-Ser-Thr-Phe-Glu-Glu-Arg-Lys Format: Sterile Lyophilized Powder (Vial) Modification: Pegylation (Polyethylene Glycol Attachment) Purity: >98% (HPLC) Content: 5mg per vial

Product Overview

PEG MGF (Pegylated Mechano Growth Factor) is a chemically stabilized form of the autocrine growth factor MGF. While native MGF has a half-life of just minutes, the attachment of a Polyethylene Glycol (PEG) polymer protects the peptide from enzymatic degradation, extending its biological activity to 48-72 hours.

This modification allows for systemic administration, enabling the peptide to reach distant tissues (muscle, heart, nervous system) to activate stem cells and promote tissue repair, overcoming the limitation of native MGF which acts only locally.

Mechanism of Action: The Sustained Activator

PEG MGF functions by activating the "Phase 1" repair response in tissues.

• Stem Cell Proliferation: Activates the MAPK/ERK pathway in satellite cells (muscle stem cells), driving them to multiply. This expands the population of cells available for repair before differentiation occurs.

• Pharmacokinetic Stability: The PEG shield increases the hydrodynamic volume of the molecule, preventing renal filtration and proteolysis. This transforms a fleeting local signal into a sustained systemic therapeutic.

• Neuroprotection: Protects neurons from ischemia and degeneration by inhibiting apoptotic pathways, independent of the IGF-1 receptor.

Key Research Applications

1. Systemic Muscle Recovery Ideal for research into generalized muscle wasting or recovery. Because it circulates for days, a single subcutaneous injection can target multiple muscle groups, promoting the replenishment of the stem cell pool post-exercise or injury.

2. Cardioprotection In models of heart attack (myocardial infarction), PEG MGF reduces infarct size by preventing cardiomyocyte death and recruiting cardiac progenitor cells to the site of injury.

3. Neurodegeneration & Stroke Investigated for its ability to protect motor neurons in ALS models and rescue hippocampal neurons following stroke. The PEGylation allows for sustained neurotrophic support.

Storage & Handling

• Physical State: Lyophilized (Freeze-Dried) White Powder.

• Storage (Powder): Store at -20°C (Freezer). Stable for up to 12 months.

• Reconstitution:

  • Solvent: Bacteriostatic Water.

  • Solubility: Highly soluble.

• Storage (Liquid): Store at 4°C (Refrigerator). Use within 4 weeks. PEGylation significantly improves stability in solution compared to native peptides.

Disclaimer

FOR RESEARCH USE ONLY. This product is a chemical compound intended strictly for laboratory research and development. It is not approved by the FDA for clinical use, diagnostics, or therapeutic procedures in humans or animals. The physiological and toxicological properties of this chemical have not been fully investigated.